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                    <text>“w

w

A-

~

.w ‘~;“wV-Fw-vvmr

.v

rwwwn-u.wumAv'v‘ur’."

-

NNK‘VW"“¢ "Wm

~

an:

A.“

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”-

‘

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r
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"-v

run

September 28, 1970

-'~=v't

r.“

:1
«‘u

..

:c'

Dr. Wiles Harrison
Geigy Pharmaceuticals

Ardsley,

New York

-h’\r~'lw‘ﬂ’..5.m-

Dear Wilma,

91

A

2

cum;

I have read the two EEG studies of GP 41299 by Kales and
Denent with great interest. I have read of Kales' sleep studies
for a few years, but this is my first opportunity to directly
compare my techniques with his. Dement has not previously been

identified with

new drug

studies.

Both studies suggest that GP 41299 enhances REM activity a finding interpreted by Deuent as almost unique (see pg. 23).
Kales failed to elicit effects on REM at 50 or 100 mg doses.
Both Denent and Kales, for reasons that are not specified,
suggest studies in insomniacs. This recommendation does not
seen to be based on the study data, but on information which

is not clearly stated.

striking, in both studies, is the absence of statistical
sophistication in defining the drug induced EEG changes. I was
surprised by the small sample size, and the impressionistic nature
Most

of the

summary

statements.

I cannot determine the relation of this data to the alert
but I am most grateful
profile of GP 41299 as we defined
for the opportunity to examine these studies and to attempt such
a correlation. I find nothing in these data to be inconsistent
with our observations or conclusions, and would continue with our

it,

BEG

suggestions.
and

Again,
my

my

thanks for the change to read these two reports,

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>September 29, 1970
Chairman

Internship Selection Committee

Dear

Sir:

to me as a Summer Research
Trainee in 1968. He participated in our study program of EEG
changes with psychoactive drugs in normal volunteers. He became
Mr. Alan D. Morris was known

acquainted with the normal human electroencephalogram and developed
an appreciation for the subtle changes accompanying threshold

drug dosages.

an intelligent, cooperative and friendly young man.
grﬂat efforts to accomplish his assign-ants. He exhibited
an enthusiasm for pharmacology and I very much enjoyed discussing

He
He made

is

his ideas.

Since his freshman year, I have occasionally met him at
meetings in the College. He continues to exhibit an enthusiasm
in medicine and I would recommend him highly for continued

training.

Sincerely yours,
Fink, M.D.
Professor of PsyChiatry

Max

MFtkt

�</text>
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                    <text>....

v vw "nav'uwl: m'JKIL-‘r

-:"'n;'!.‘—K\

urn-n

u n. v-ww:""~ "'0’..’ll"~ ~r-wrmn~m

hwy-‘4

w.

at;

Wu.-

..~...--

._.

.

v

m

.7

,.

r,
v,‘,-.—
_.. “re—v7“
“'Kif’ . Kan—".7 '11 .w.
,

,

wVlrr‘ \m- w... Vg....N:
,

.

.

M

2 -.~

September 30, 1970
Addiction Research Foundation
344 Bloor Street West
Toronto 4, Canada

,..._.,

.

.Jymwuwu.

Wham.

rm

ﬁn-

Gentlemen:
I have received "An Interim Guide to the Cannabis (Marihuana)
Literature” by Oriana Josseau Kalant and I have read it with great
interest. I wish to commend the author for a clear and unbiased
review of a difficult subject. For those articles which I already
knew, I found the technical statements clear and usefhl.
Many

thanks for sending

me

a cepy.

Sincerely yours,

WT:

Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>.

September 30, 1970
Dr. Milton Tarluu
Kew Gardens General Hospital
80-02 Kew Gardens Road
New York, New York 11415
Dear

is an abstract for your consideration for the
meetings. If the topic interests you, I would be
pleased to bring the membership up to date with an interesting
Enclosed

1970 EAEEG

set of practical developments.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

"HT-WW

‘
t

1

”ﬁrm

Murrow

~x

Milt,

Mszt

—r~.—-.-wv.

"’J-rww‘

-

�</text>
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                  <elementText elementTextId="103348">
                    <text>rumm‘pwm.t-“W,

Wynn-n.

”WW—W5 ---A1mw wﬂ-r‘

n—de—WJ'M

.,

w

"NV-V

“a

';:I-«urql’."‘ ”aw:

warm r" WV-v' WW

*1

4

W"? “V“

' " “'

July 3,

"‘

'

1970

.

"are—xv

«um-WW“

,,
,.

Dr. Ernst Rodin

Lafayette Clinic
951 East Lafayette

Detroit,

Michigan

,.,

H,

.,
v

rpm".

Dear Ernst,

our".

A

.w‘twﬂ'mI-T‘qunw;

r

('"Y‘lxﬁ'wv'rn‘nv-t

m,

_-i-Vyrt&gt;

-("th,

em.

3-5:",

I want to thank you for your courtesy and patience
in explaining the operation of your IBM 1800 system, and particularly
your use of that system for data acquisition and processing. It
was kind of you to take the time from your busy schedule, and I
am

most

grateful.

Perhaps, I did not express my enthusiasm for your
observation of very fast frequencies in the EEG. When Turan and I
looked at fast frequencies, we looked at 80-150 cps, and in one study,
of the effects of pentothal, we found interesting frequency changes,
but these were not unique to the fast bands, and we were not sure that
we were not dealing with artefacts. Your focus on truly fast frequencies
is most interesting and I look forward to the report and the responses
at the EEG meetings this fall.

-.7,Wawwn

My
.12y.~

best wishes for

a happy and healthy summer.

Sincerely yours,

Iii-(vsm'mmtmmﬁ

Max

WHHW

mf/

Fink, M.D.

�</text>
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                    <text>«equw-r-au

~

mgmrwnvmmgv

nun-‘3.

cur-\—

rw

ﬁi'wﬂlw

nan-"Iv

Ms...

July 3,

1970

Dr. Alex Karczmor
Stritch School of Medicine

Loyola University
Chicago, Illinois
Dear Alex,

notified by EIMH that our application for
supplementary support [or the studies of CS? in the ECT process
We

was

have been

not accepted.

Dick has sent one sample, and during the past 2 months
we have been writing up the results of the first tsudies and planning
the new ones to begin'in late September. I do not know what
arrangements we can make, but I believe that we will be able to make
samples available and hope that we can work something out.

I will call

and we can decide then how
My

after

return
to proceed further.

you immediately

best regards for a

my

from summer holidays

happy summer.

Sincerely yours,
Pink, 3.9.
Professor of Psychiatry

Max

P.B.

we

should have a dinner in Prague, at

_

least

1

W

�</text>
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                    <text>July 3, 1970
Dr. William Martin

Addiction Research Center
Lexington, Kentucky
Dear

Bill,

meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
his preparation could be assessed in
Dr. Seymour Yolles, to see
Following our June

4

if

clinical trials.

him this
I called
about his

week and found him most cooperative

preparation. He can make some samples available
reluctant
for animal assay now. He seemed
trial this fall;
for
N.I.M.H.
made
under
was
his
supply
to deal with us directly, indicating that
He
wished
the
next
should
decide
steps.
grants, and that rightfully, they
to first obtain your approval for release, as well as the permission of
and enthusiastic
human

and

Dr. Sidney Cohen.

Since you have been instrumental in setting up his program,

it not be

assume the responsibility of’assuring
his cooperation as well as that of N.I;M.H. (Dr. Cbhen ?) to bring this
method to early trial 7 Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. rolles
the program can be implemented.

would

useful for

you

if

to

'

accepted by

Incidentally, the summary of the June
the editor of’Science for publication.
my

4

meeting has been

best regards.
Sincerely yours,
Max

Fink,

M. D.

Professor of’Psychiatry

"#7

cc: Alfred FreedMan
Seymour

rolles

�</text>
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                    <text>A.

.
t

WW,

n...“

“F...

July 3, 1970
Dr. Ralph Jacobsen

Endo

Laboratories

Garden City, New York
Dear Ralph,
Thank you

for the corrections to the

summary

of the

meeting. I will make the changes, and I am pleased to
the
that
summary has been accepted for publication in Science.

June

4

we

tell

you

have had an opportunity to discuss the problem of continuing

our studies of oral naloxone. Aware that our request for additional
supplies for oral trials remains unfulfilled, we have requested support
from the New York State Narcotic Addiction Control Commission for our
independent purchase of naloxone from any available source.

It is my understanding that Mallinckrodt Chemical Co. is
the principal U.S. source of the compound. I have written to the President
of that company, enquiring as to the possibility of their supplying
naloxone for our use.
I

would appreciate ypun cooperation in

this request.

It would also be helpful if you could tell
potential sources of supplies of naloxone.
Many

us of other

thanks for your cooperation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>a.
u.

rv'u‘vr

aux—nu.

.7

,_",.c,m..",

,

r u .

nwvw-c raw—W

'

'v-r

:

raw

1"

July 3, 1970
Dr. Ed Domino

Lafayette Clinic

Detroit,

Michigan

Dear Ed,

It was kind of you to spend so much time with me on
Tuesday. I was very impressed with your facilities and with the
catalog of interesting studies which ydu and your associates are

undertaking.

I am particularly interested in your studies of
acetylcholine and cholinesterases. For the past 18 months, I have
studied the behavioral, EEG and memory changes induced by unilateral
and bilateral ECT, and recently have expanded the
study to include
multiple monitored ECT, in which the subject receives
3-8 seizures
1g one sitting. In reviewing our data, and in View of the
interest
in CNS neurohumors in depression, I became interested in measuring
the neurohumors in the spinal fluid of these subjects.
Alex Karczmar expressed enthusiasm for this study, and
have planned to send him samples, taken before and
after the
induced seizures. As you know, the techniques are
notoriously
difficult, and any collaboration and assistance, would
be most welcome.
If the problem is of interest to your associates, I would
to make samples of spinal fluid available to you as well. be pleased

we

If the problem is of interest, may I ask that you arrange
to have your assistant write, describing the necessary
to be taken in sample collection, sample size, shipping,precautions
etc.; and
we will send you a detailed protocol (now under
revision) and make the
necessary arrangements for the fall.

trip

my

thanks for your time, and my best regards in your
It sounds interesting and I look forward to a report

to Russia.

this fall.

BSncerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>"’f‘mm’w" 'un-W‘

:r’alww .mu-zw—a—wwq-p-mvm

w-“

July 3, 1970
President
Mallinckrodt Chemical works

St. Louis, hissouri
Dear

Sir,

Since 1968, we have carried out clinical studies of
naloxone in the treatment of’opiate dependence. Supplies have been
provided by Endb Laboratories, but they have been unable to
make sufficient nalosone available for oral studies. In December
we requested additional supplies and these have not been forthcoming;
they have indicated that the supplies are male in your laboratories.

In discussing this with the officials of the New York State
Narcotic Addiction Cbntrol commission, they offered to make funds
available for our independent purchase of'naloxone; and such a
contract has been received by this Department.
would like to purchase 3 kilograms of'nalcxone; preferably
in 300 or 500 mgm tablets or capsules. Is it possible for
your laboratories to make such a quantity available? At what cost
we

made up

and with what delivery schedule ?

are unable to supply this quantity, can you direct
If youlaboratories
either here or abroad that can ?
other
to
us
an...

We

am..-

'1

--

either

U.S. customs,

have

or can obtain the necessary

etc. clearances.

FDA, BNDD,

my".

Thank you.

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

mf/
cc:

Endb

Laboratories

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                    <text>July 3,

1970

Dr. Allen Berger

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,

first

I enjoyed your visit
installment of the material

on June 23, and I

we

am

discussed.

enclosing the

have prepared a protocol for the assay of the
Infiuence of.PCPZ"5h Tolerance and Physical Dependence in Opiate Addicts.
We have reviewed the administration schedule, and following your discussion,
have added trials of PCPA on alternate days and daily, if the schedule
of every 4 days is inadequate.

1.

PCPA.

We

,

for this project, that
is one technical problem5-HIAA.
we do not have
and
5-HT
urinary
blood
of the measurement of
have
contract these
and
to
will
the facilities for this measurement,
can be done in
unless
they
commercial
laboratory,
measurements with a
assuming the
contract
the
costs,
Our
for
estimate
your laboratories.
is $3,000.
number
tested,
of
maximum
cases
project proceeds to the
There

have reviewed the data on cidoxepin and
Presumed Anti-Anxiety,
prepared a protocol, Elinioal Trial of CidaxapinWe
would
like to assess
Dependence.
Anti—Depressant Agent~ In Opiate
2. Cidoxepin.

We

in this
the possibilities of clinical trials of anti~depressants
of patients.
number
limited
a
in
and
a
suggest trial
special population,
and
clinical
dosage
define
range
a
able
be
to
In this study, we should
definitive
a
be
able
to
suggest
will
activity, and based on this data,

trial.

We

the

summer

holidays,

the supplies

be able to begin the cidoxepin
on or about September 15.

will

trials

only

after

(we can begin the PCPA study in mid-July or as soon as
are made available. 200 capsules of 25 mg. each should

be adequate to

3.

start; with
EEG

matching placebos

if possible.)

Trials in Prison Volunteers. This suggestion is

most interestingT"EEa‘yaﬁf'f5116ﬁ=ﬁp’feliphoﬁ3'call to indicate that
your technician will visit us on July 17 confirmed our enthusiasm. To
will be necessary that equipment be available
carry out this program ,

it

..,.,

,
a
A-

.
-‘Wrwv

�at the prison to insure recordings that will be useful. I will
describe our procedures and caution the technician, but the following
should be considered:

equivalent to Grass polygraph with 7P511 amplifiers.
Grass Instrument makes a small 4 channel instrument, which can be
initially equipped for recording on 2 chainels only. $4,500 ($3,000)
EEG,

Tape—recorder for FM.

to the Hewlett Packard

A

3690A.

small 1/4 inch unit equivalent
$4,285

Oscillator, equivalent to the

2020

HP

$

425

Oscilloscope, for monitoring, preferably dual

beam, any make equivalent to the Tektronix 561

inexpensive.

The

tapes, paper,

$1,000

and other supplies are

relatively

it

would be useful for me and one member of my staff to visit the installation and develop the initial
protocols in collaboration with your staff there. I would envisage
the recording of EEG samples on paper and magnetic tape; having the
paper records examined in conjunction with the clinical data; and then
analyzing those tapes that seem the most useful for the definition
of drug dosages using the advanced computer techniques of the EEG

Prior to the studies,

laboratory.

not have a 1/4 inch FM tape
unit in out computer center. It will be necessary for us to provide
a duplicate unit or for you 00 lend us your unit whenever we undertake
the analyses of the tapes.
As

I mentioned,

we do

4. EEG Profile Study of Doxepin Pamoate. I have not
received the pharmacological data for this formulation, and so have
hesitated to prepare a protocol, but will do so as soon as the infor—
mation is received.
The thiothixene-EEG

reports are progressing rapidly.
Thank you

these diverse studies.

profile,

and the

for your suggestions,

CP

14,368

EEG

and I look forward to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

profile

�</text>
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            <elementTextContainer>
              <elementText elementTextId="44767">
                <text>1970 </text>
              </elementText>
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              <elementText elementTextId="44768">
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              </elementText>
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            <elementTextContainer>
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            <elementTextContainer>
              <elementText elementTextId="44772">
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              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="44773">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
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            <elementTextContainer>
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            <elementTextContainer>
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      </tag>
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  </item>
  <item itemId="4476" public="1" featured="0">
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        <authentication>2b1971c9d3be1ed80750d66cc5298272</authentication>
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            <description/>
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              <element elementId="52">
                <name>Text</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="105955">
                    <text>N‘—

"

4»

-'~~=-

-

u-u-

.—

~-r-r..~u.w—

u- . , grim

"w' ..:,

w. ‘v-‘(M' v.

,

.

.. .-..._..m=—~wmw~wqur-.muvv.nw 2-“

«W

.5 .‘If‘l:

no. ”warm... .7,..,,.,

July 3, 1930
Dr.

J. Alan Burdick

university of’Manitoba Faculty of Medicine

Hinnipeg,

3

Manitoba

F
E

Dear Dr. Burdick,

Perhaps there

is

need

for such a

volume as you

and we should contribute to it. I do not know when
find the time, but should try to do so this fall.

I will

project,

be able to

I'would like to describe the development of.EEG
emphasis
quantification of’special interest to psychopharmacology, with
the
to
analysis,
frequency
in
analog
on the historical beginnings
as I have in my
present digital computer methods. I will weemphasize,
considerable
had
have
EEG,
human
although
waking
studies, the
As a
methods
recordings.
to
sleep
these
experience in applying
useful descriptive title, I would suggest:
Quantitative

EEG

and Clinical Psychopharmacology

Spectral Analysis and Clinical

Pharmacology

or,

EEG

or,

Applications of'Digital Computer Analyses of the
EEG

Ag

to Clinical Psychopharmacology.

co~author will be Donald

Good luck

M.

Shapiro, D.Sc.

in your venture. with such a project,

you should be able to interest a good publisher and obtain a
which may bring a return to the contributors.

to have you

.Lf you

Human

visit

New

York,

visit our laboratories.

my

associates

I believe
contract

would be pleased

Sincerely yours,
muﬂw‘

was:

Fink,

M. D.

Professor of.Psychiatry
mfy

�</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="44757">
                <text>1970 </text>
              </elementText>
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            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="44758">
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              </elementText>
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              <elementText elementTextId="44762">
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            <elementTextContainer>
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  </item>
  <item itemId="4475" public="1" featured="0">
    <fileContainer>
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              <element elementId="52">
                <name>Text</name>
                <description/>
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                  <elementText elementTextId="105954">
                    <text>r
..

mm“

“Hwywr

M

-

wvw-ucv'wr W. ”Minn-'M

,

r'

way-rm:n .

3‘

‘I'S’WmMun-1w new

‘wm'm 'm—Ur 4mm? m:m.ww—nr

-

.w

'[vpv-p—n!‘;.

s..ww‘wu‘m.

"WW4.

July 3, 1970
Dr. Vilma Harrison
Geigy Pharmaceuticals
Ardsley, New York

mm.

.

---Im‘-'Zv";r

Dear Wilma,

n‘

w:

As

I mentioned

on the phone,

I have

discussed the

willing, interested and able to evaluate the
list of clinicians
and
antianxiety effects of new compounds with some
antidepressant
and
with Dr. Stephen Bernstein of the ECDE'U program
associates
my
of
The
MIMI.
following
investigators should be considered for
of
an evaluation of GP 41399.
Schiele and Abussahab:
University of Minnesota
Cole, DiMascio, Schader:

Goldstein:
Rickels:
Merlis:
Klein, D.:

Boston State Hospital
University of Mimi

University of Pennsylvania
Central Islip State Hospital
Hillside Hospital

There must be others, but they do not come to mind in this
review. Occasionally, Hollister (V.A., Stanford) has taken on a new
compound; Sugerman has done some OPD studies at a private hospital in
New Jersey; and Gallant (Tulane U.) has reported on cmtidepreseant and

antianxiety
to

compounds

in alcoholics.

is anything
I trust this is helpful.
Ifonthere
me.
in
call
this
assist
venture, please
My

I

can do

best.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
mf/

.

,: m.wan—m ,r-wW

:s

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                    <text>v-rr—uv

wrw-r

thml-vzwu.vwwwww

m

v.

July 3, I970
Mr. John E. Ringle

Science
Washingfon, D.C.

Dear Mr. Ringle,
In re—readlng fhe reporf of The meeflng on Narcotic
Antagonists in Opiata Dependence, we have made a few smaII correcflons
In +he fex+. A correcfed copy Is enclosed and we would ask Thaf fhe
copy edlfors use +his correcfed version for preparafion of fhe

galleys.

Many

Thanks

for your cooperaflon.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry
mf/

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                    <text>July 3, 1970
Dear Helmut,
have
Iand

discussed your questions about EEG analysis with
with Itil, and suggest that the best methods for
my associates
your applications are still the frequency analyses using the filter
techniques available in Europe. These techniques, as provided in
the analyzers made by Kaiser in Denmark or the fixed filter units
available from England will db the job very well, at much less expense
than any of the computer methods. As I understand your problem, it
is to measure the EEG changes under different conditions of‘cerebral
dysfunctoin, and for this a frequency analyzer is ideal; particularly
since you will be able to compare the differences between electrodes
pairs on two sides of the head. Our focus in computer methods is
largely because we are assessing the methods for special problems
in which the changes are small and we have to depend on changes from
session to session or after a drug.
The equipment has been used by the Czechoslovak group
working in Prague with good results, and they have had the Kaiser system

for

many

years.

Good luck I

thank you fbr your kind invitation to visit. I will be
at the CINP in Prague this August, but my present schedule is complicated
by the desire of'my family to visit some of the sights in Greece and
Turkey, where I have projects. I do not think it will be possible

I

to visit Gras with them this trip, but I will be in Europe again this
year, and will make a trip to Gras, not only to visit your laboratory
but to try gliding as well.
,

It

was good

My

best regards.

answered your questions.

to have you

visit,

and

I trust that I

Sincerely yours,
Max

Fink,

M.D.

have

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..

gunner... n.

w

".m‘mw...~.—m.;.

..

‘1

.r

1.1.1,;

ﬂyww .q.vv..-»,—lwm~

July 3, 1970
Dr. William martin
Addiction Research Center-

Lexington, Kentucky

.
..

Dear

Bill,

’lWlU-m.NV1'-

”Hwy-e

ea;

Following our June 4 meeting, Al and I have discussed the
next steps in our narcotic antagonist program. He suggested I call
Dr. Seymour Yolles, to see if his preparation could be assessed in

clinical trials.

I called him this week and found him most cooperative
and enthusiastic about his preparation. He can make some samples available
for human trial this fall; and for animal assay now. He seemed reluctant
to deal with us directly, indicating that his supply was made under N.I.M.H.
grants, and that rightfully, they should decide the next steps. He wished
to first obtain your approval for release, as well as the permission of
Dr. Sidney Cohen.
Since you have been instrumental in setting up his program,
be
not
useful for you to assume the responsibility of’assuring
his cooperation as well as that of N.I.M.H. (Dr. Cbhen ?) to bring this
method to early trial ? Al and I would be pleased to make our facilities
available for these studies, and would be grateful to you and Dr. Yolles
the program can be implemented.
would

it

if

Incidentally, the summary of the June
the
editor of‘Science for publication.
accepted by
ﬁg

4

meeting has been

best regards.
Sincerely yours,

.
WV.

Max

.7

Fink,.M.D.

Professor of'Psychiatry

«w‘w.wv.w‘,m...

mf/
cc: Alfred Freedman
seymour Yolles

10..."..1‘

..

x

._—.

m”-

.

�</text>
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                    <text>\\
July 4,

1970

Dr. Robert Gerber

President, APA
Carrier Clinic
Belle

Mead, New

Jersey

Dear Bob,
The form APA letter of June 30, signed by Mrs.
_Frances Davie, epitomizes the basis for my resignation from the
APA. In reading this letter, I was prompted to think of the reasons
for my abrupt action, and a relationship of almost 20 years prompts
me

to express the reasons for

my

distress.

I joined the APA about 1951. I was active in my district
branch, the Nassau NP Society, founding its Newsletter and becoming
President in 1959. I was also active in the APA, serving as an officer
of the Section on Brain Function for many years; have often presented
papers and participated in round tables at meetings; and refereed many
articles for the Journal. For the past year, in my district branch, I
have served as chairman of the committee on biological therapies. In
view of this active relationship, why this action and why now ?

I believe the APA is much too big and too impersonal. It
is insensitive to the needs of individual members. It tries to speak for

all,

not

and

my

I fear

views.

may

Speak for none. Surely the views of the

APA

are

Some of the impersonality is seen in the following incidents.
In 1966, I returned from St. Louis, where I served for four years to
establish the Missouri Institute of Psychiatry. On my return, I was
invited to participate again in the committees of the Nassau NP Society.
Because my office was in New York, and because it served the interests
of the Department to have me participate in that society as well, I applied

for membership in both, and was told by the APA that it was illegal
to be a member in two district branches Dutifully, though disappointed,
I resigned from the Nassau NP Society. (Incidentally, the threat in the
last paragraph of Mrs. Davis' letter is childish.)
1

APA.

For years I have participated in section meetings at the
Host general sessions are much too big to allow discussion. The section

�small, and though it occupied only one day of the meeting, served
to provide continuity for discussion and growth of ideas. The demise
of the sections provided another loss of the personal touch of the society.

was

The APA meetings receive many abstracts, and the
Program Committee complains that
is overburdened. For a number
of years, I have recommended presentations by younger men, only to
have them rejected. Surely this would not be a problem, if we were
not repeatedly faced by programs in which some participants present

it

more than once,

often the

same

material in different sessions.

For example, in San Francisco, the NIMH Bunney—Goodwin team presented
many times. This is another example of lack of sensitivity.
The dues increase, while necessary to assure a larger
administrative structure, is another symbol of 'hig business', and
served as the triggee to my resignation.

Perhaps this explanation is merely a rationalization
for frustrations; or, perhaps it is a reflection of the necessary
growth of the association. I hope it serves the Trustees to consider,
if only in passing, the drive to impersonality in the association.

Is

it trily

necessary
My

7

best regards, and with the awareness that the
is often thankless, I remain,

job you are doing

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>vﬂ‘v'p'...“

w-w—wu.-us

”wan-mu

-1«p

1'
..

.mmnv

[Win-("wwnz-m'QUW‘WV-U—r

JN'H

July 6, 1970
Dr. S. Clyde Strickland
Merck Sharp &amp; Dohme
Welt Point, Pennsylvania 19486
Dear Clyde,
we would

appreciate

acetylmethadol.

Enclosed

an

is

additional
a signed

10 Grams
IRS 2513.

of L-alpha-

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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V

July 6, 1970
Dr. Stephen B. Bernstein, Program Head
Early Clinical Drug Evaluation Unit
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Steve,

Enclosed is a contribution for the ECDEU Intercom. If it
is too long, I will be glad to edit it. Our programs are, as
you see, quite extensive, and perhaps this report should be
divided over a few issues.

In thinking of this summary. and

perhaps an

article

can be

my

recent cell to you,

written in Intercom to describe the

populations available to each unit. It would give us a better
view of the basis for the results discussed.
Another topic of interest is the prison methodology for
early phase I studies - who does it, where and how?
Thanks for the invitation to contribute, and my best wishes
for the success of this endeavor.

Sincerely yours.
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

ﬂxn'géa

_

r.

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                    <text>July 6, 1970
Dr. John A. Scigliano
Center for Studies of Narcotic and Drug Abuse
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015
Dear Dr. Scigliano:

have completed one study with the marijuana recently
supplied us and are planning to undertake two studies during
August. In one we will use marijuana left,es£ the amount left
is adequate for our needs.
We

we wish to test the marijuana extract
hand the three ampules 880 #61152 rated
have
on
distillate.
AQ-THC.
To
17.12
at
carry out this study we will need an additional
three ampules.

In a second study
We

it

would
be
few
weeks?
next

possible to obtain this supplement within the
\

For your information I am enclosing a summary of our recently
completed marijuana experiment as well as a record of our drug use.
Thank you very much

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszp

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                    <text>'wamw'l‘van’

-)

July 25, 1970
Dr. Charles Socarides, H.D.
210 East 78

New

Street

York City

Dear Dr. Socarides,

I thank you for your kind invitation to participate in
a panel on the ”Efficacy of Treatment of Narcotic Addiction" on
February 2, 1971 at the New York Academy of Medicine. The subject
to my associates.
is of importance and of keen interest to me andabout
the treatment
to
have
say
nothing positive
Unfortunately, I
are unconvincing,
other
laboratories
tron
of addiction, since the results
the
If
title or
are
incomplete.
and our own data, while promising,
under
study,
of
the
approaches
discussion
the focus were changed to a
scientific
approach,
its
unique
describe
our
then we would be willing to
and

theoretic basis,

and the

initial results (if

we

have them by that

are testing the theory of opiate dependence
time).
you know,
therapy based on de~conditioning using narcotic antagonists like
cyclazocine and naloxone. This approach is rooted in experimental
studies, chiefly from.Lexington, in animals and man, and bearsthelittle
resemblance to the emotional approaches usually described by
other workers listed in your letter.
With this caveat, and in the spirit of inquiry, I will
be pleased to accept your invitation, if you choose to accept these
remarks as descriptive of the presentation that we may make.
As

Again,

we

my

thanks for your

invitation.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

P.S.

be based on the joint efforts of Professor
Resnick, Dr. Arthur lake and myself.
Richard
Alfred Freedman, Dr.
The

presentation will

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                    <text>,

-

,

H...

.

t

‘.

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&lt;

:vmlr

«

“ www

rm

«my»,

.

,1,

.\ .‘wwa-mv‘w—P

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July 3, 1970

56Vaaﬁ'
.3

60?:

Dr. Konstantine Miras
Professor of Biological Chemistry
U
iversity of Athens School of Medici ahe

Athens, Greece
Dear Costas,

While we have not yet received the formal
from N.I.M.H., both A1 Freedman and I are proceeding oncontracts
the assumption
that we should take advantage of our forthcoming trip to Europe
to meet with you to discuss the details of the project.
Dr. Freedman can arrive in Athens from Tel Aviv about
August 13, but I am scheduled to be in Prague until August 15. I hold
reservations Prague (ZRH) Athens on Saturday, August 15, arriving
in Athens at 1835 ()A 723). We both are scheduled to leave for
meetings in Istanbul on Monday, August 17 ate 1700 (BEA 438).
We plan to
stay at the Grand Beetagne Hotel, and would
appreciate meeting with you on Sunday and Monday. It would be useful
to meet once again with Dr. Stefanis, and other members of the staff
who may participate in the
project.

After the meetings in Istanbul, I plan to return to
my family for a holiday in the city and among
the islands. This will also give us an opportunity to meet
again
to continue our planning sessions, if this is necessary.

Athens (August 21) with
I

Our

best regards.
Sincerely yours,
Max

Fink, M.D.

�</text>
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ww‘w ',V"-~v,v1"-V“»‘.x _‘-V.':‘ we.

,

V

A

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‘37-. 1-

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July 7,

..

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"v.

“1.”...

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m

w,

M

1970

Dr. E. N. Terry, M.D.

Pharma-Researcb Canada Ltd.
250 Hymns Blvd.
Ponte Claire, Quebec Province
Dear Dr. Terry,

I am pleased to accept your kind invitation to
the laboratories of Behringer (Ingelheim) in August.
.

visit

I will be in Athens From August 21 to 26; and hold
reservations to leave Athens for Frankfurt on wednesday morning.
August 26 on TWA 741, arriving in Frankfurt at 10:30 a.m. I also
hold reservations to leave Frankfurt for New York on Monday, August
31 at 13:45 on PA 73.
wife and two daughters (age 14 and 12) are accompanying

My

me.

I will be available to visit both installations, at
Thomas on Thursday, Friday and Saturday. If necessary
and
Ingelheim

or advisable, I can delay

sights

departure to

New York

for September 1 or 2.

make arrangements for hotel accommodations
would
be pleased to rent a car and visit the
family
about Frankfurt, and the castles of the Neckar during my
Would you

near Frankfurt

many

my

? My

kindly

working hours.

Many

opportunity to

thanks, again, for your kind invitation and for the

visit

your laboratories.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

P.S.

May

I

tell

compounds

you

that

that I have not received the descriptions of the

you discussed with me

?

V

.

_r

&gt;

( .

V.

_

”A

if,

�</text>
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                    <text>July 7, 1970
Mr. Robert V. Ornea
Managing Editor

Science

1515 Massachusetts Awe., N.W.
Washington, D.C. 20005

Attention:

Miss E. Johnson

Dear Mr. Ormes:

our meeting report,
I have reviewed your suggestions forhave
corrected each of
I
and
acceptable.
and find them useful
(I am not
the checklist items and enclose a citationa list.
and 7 and 9];
and
6,
[aee_items
sure how to handle repetitions
please correct).
cogent
Since submitting the report, A. Wikler submitted amarked
have
2.
I
1,
page
addendum which appears as paragraph
version for
my new page as you did, but enclose the earlier
your checking.
Thank you

for your able assistance.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kp

em: a

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&lt;
-

July 07, 1970

wﬂ'm""-‘

A,

.
.v

-v~'."!va14

Hearing Clerk
D. H.E.W.

Fisher’s

5600

Lane
Rockville, Maryland

”raw-1tma

Re: Methadone Regs, Proposed

Sir:

Dear

I am writing in response to the proposed regulations
”Conditions
for the Investigational Use of Methadone". Since
entitled,
1965, this laboratory and Department have been involved in studies of
methadone maintenance and other forms of narcotic antagonism (cyclazocine,
naloxone). I believe the exclusions listed, namely peegnancy, psychosis,
physical disease and age less than 18 are too restrictive, and possibly
illogical. I would suggest that these exclusions not be written in the

regulations.

'

The treatment of pregnant women is a logical step in
the methadone maineenance programs. After all, who is in more need of
help out of the sordid drug addiction cycle than mothers ? We do
not know whether methadone is safe and surely every effort should be

to investigate this application.

made
lﬂ’m'l'cmrwtwﬂ'w‘ﬂrw"

effects in
seems

Psychosis

some

be helped by methadone, which has antipsychotic
and such a study should he encouraged. Again, it

may

reports,

illogical to restrict this medication, if it is indeed helpful,

to healthy addicts only.

.rnwrmrr-n-r.

squash-F“qu

.

applies to serious physical disease. We have
successfully treated a number of older patients with eveidence of
cardiovascular disease and methadone may have heen life-saving in these
subjects. Rather than restrict the studies, I would encourage these
The same

trials

as

are to

we

particularly helpful.
If one restricts methadone to persons over 18, what treatments
offer the younger addict ? What is the magic of '18' ? While

it

would be unfortunate to start younger persons on
one may agree that
a life of addiction to methadone, is the same not true for an older person

the

These
and

artificial

restrictions are illogical to

puritanical

me, and may represent
views of the authors of this regulation,

little experience with treatment of opiate
dependent subjects with methadone. If they had, the regulations would
reflect an expression of the need for these studies, rather than their

who, I suspect, may have had

exclusion.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.......

as. ......_ ...

?

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                    <text>,.

r..4,‘.~.‘

.m,‘

.

v

,.

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. .w, ‘ .

w

..

.,

”-1

. .

, .
7,,,, .ﬁ,

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u

..,r “HMLWW .
.

,.,
“W“...

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_

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,

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n-

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xd-Y"

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~

rm

v‘m'wr‘wpwdu

w.

.

w‘vavrp—

w...—

Yamnwnwmww.

‘—

'wwavﬁ

July 9,

u.

,7,

,r,

3

E

E

é

1970

Dr. Allen Berger, M.D.
Associate Director
Pfizer Pharmaceuticals
Groton, Bonnecticut

:

g

Dear Allen,

%

g

the

FD

Following your message, I recalled the envelope with

forms enclosed, and added the following?

E

E

%

68—06~26:

68-06-25:

g

i
i

68—06—27:

for the lactate study, including,
form
Anxiety scale for infusion
Forms

Initial evaluation

Taylor Anxiety symptom check

list

Article from Archives gen. Psychiatry, by Curry et 31.,
Factors Affbcting CkZorpromazine Plasma Levels in Psychiatric Patients,
vol. 22:209—216.
I trust these are useful.
Sincerely yours,

.A

"w"

Max

‘va‘nI-Kﬂqup‘—VV7

mf/
ru-u'ﬂ’

-:
'

r-vwwawrxv-v

w'

vxvn-

u-

‘wﬁwmn"w"ﬁw'mwxw~

Fink,

M.D.

‘

._.

v

n

~-«

-,

-- ~-.-,—,.\._

q . Jam-w urn-cavin—

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m

‘unmwm"

m.»

Ir ..,.

“WW?

July 9, 1970
Mr. Fred Brunner
IBM

Corp.

475 Northern Blvd.
Great Rock, New York
.,..

.7".

v

Dear Mr. Stunner:

«mpv

W

..

Pleas. arrange to cancel

day the ordered

RPW

1443 (1800)

is installed.

rental

on the same

~wwmv:'vl—:E.w—

Sincerely yours,
«V:

-&gt;-

Fink, M.D.
Profeesor of Peychiatry

Mex

‘nl-D-gl-"

.A...

VA

auxrm-q-m-vwwwu—uur

r.

wry-v»,

T_

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WWW

Hrzkt

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July 10,

14w

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.w-

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mne-

Mr. R.

J. Gradwell

National Institute of Mental Health
5454 Wisconsin lvenue
Chevy Chase , Maryland

Re: Contract HSM—42-70-98

Dear Mr. Gradwell,

Enclosed

is

a signed

DREW

certificate involving

subjects. as requested in your letter of June 22.
In reading

this letter

human

which seems to follow a standard

prior approval for foreign travel must be obtained. It in my
understanding that this contract, in justifying foreign travel as
essential to the purposes of the project, yields 'prior approval'.
I am leaving for Athens on August 4 to negotiate the subcontract, and
if this interpretation is incorrect, please advise.
form,

we"-

‘_

May I also request your secretary to send us blank
copies of Form 1034, 'Public Voucher for Purchase and Services other
than Personal'?

.,.,V

Thank you

”.77",

for your assistance in negotiating this contract.

«um-7...,”

Sincerely yours,
.z‘K’UI-'l"'g‘|nn"“z‘n-

"sun-um

Max

mf/

Fink ,

31. D I

”ms.

v-u

#‘U:WWW"W(AW

�</text>
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                    <text>July 10,

19 70

Dr. Fred Kazan
Upjohn Company
Kalamazoo, Michigan
.

.

Dear Dr. Kaban,

?
:-

h

.

--

Wm-r-mwv'u

rwv-wwwr

:mvw

ZW'u‘VCInv

‘
‘

”adv—”WW3!!!

I have checked with the New York representatives of
Honeywell, regarding the Honeywell 8100 tape recorder. They report

that the instrument was Specially designed, and does not follow IRIS
standards for head configuration, and would therefore not yield tapes
compatible with our reading system.

They indicated that Honeywell did make a Special head
which could be used to modify the instrument but this would be

expensive-~ almost as expensive as buying a new instrument. They
suggested you contact their Detroit office for further data.

“.mp1

7
w,

..

We are planning to purchase a 1/4 inch A—channel IRIC
compatible instrument for another project and would suggest that this

instrument be duplicated in Upjohn laboratories
to send us tapes. (Hewlett Packard 3960A

laboratories.

Again,

my

4

if FM
it

channel

thanks for the opportunity to

seems useful

recorder, $4,285)

visit

Sincerely yours,
Max

Fink, M.D.

your

�</text>
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rm»; '31“. arm—«avws-mm: "‘I'I‘mbwrmtﬁ-thzy‘uu.—_

,

ml“

v

»

_

.

-

.

,

V

-~&lt;wm-.

A

1

,,r,

w "W‘WI'myu-Mrw‘m m”, an” ,5",
_.

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3 .tv..\—‘.,._7,,” grew—J.

mm

“WA

1m.—

——_

-—.-_

.‘umw—‘v—‘ul-v

-

wavy-urn—

w
m

July 10,

14w

19 70

.w-

-mm~.~.~

mne-

Mr. R.

J. Gradwell

National Institute of Mental Health
5454 Wisconsin lvenue
Chevy Chase , Maryland

Re: Contract HSM—42-70-98

Dear Mr. Gradwell,

Enclosed

is

a signed

DREW

certificate involving

subjects. as requested in your letter of June 22.
In reading

this letter

human

which seems to follow a standard

prior approval for foreign travel must be obtained. It in my
understanding that this contract, in justifying foreign travel as
essential to the purposes of the project, yields 'prior approval'.
I am leaving for Athens on August 4 to negotiate the subcontract, and
if this interpretation is incorrect, please advise.
form,

we"-

‘_

May I also request your secretary to send us blank
copies of Form 1034, 'Public Voucher for Purchase and Services other
than Personal'?

.,.,V

Thank you

”.77",

for your assistance in negotiating this contract.

«um-7...,”

Sincerely yours,
.z‘K’UI-'l"'g‘|nn"“z‘n-

"sun-um

Max

mf/

Fink ,

31. D I

”ms.

v-u

#‘U:WWW"W(AW

�</text>
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v 4.- "'7»‘¢‘ 2:154.

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.~

~=

:w

mmewmswu1vsa m‘ﬁw‘w’n «92's.. c—mw “HF-’7'

..,~

“"1"

.»~

. 15-71? -1- A~-

'7‘“

"wow-:-

“"""'«"-‘\7'Iﬂwr.

July 10,
Pragotur
U

Obecniho domu

on:

1m,“

_

n’

,—..

an

m

-

'er',

,, r— ;chrr—

A

v“;

1970

2

Praha, 1, Czechoslovakia

Ref: Matejkova
CINP

Gentlemen:

Tour # 66

I am in receipt of your letter of 8 July confirming
double rooms with bath at Parkhotel. Enclosed is prepayment in the
requested amount of $ 192, our check # 543.
2

August 10

arriving at

I ask that the reservation arrival be changed to
are arriving from Amsterdam on KL 281 on August 10,

May

? We

1025.

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

.wmmm

u yr”,..v..v_..,.,w.,,,,,,v,,,.

. ,. ‘w...w,, ..,,;
,

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                    <text>W'xwm\;m.

v.

-W:w:m"r

xwx

wrumnra

um.

we

N'Ixr’m.

we".

"r,"

m",

t

1""wv.mrn v“."W"!
.

,W

..

..gqm.wﬁmw_w

W,—

mm’uW'Y-rpij‘n'mx-r‘w

,w.‘

e._r_..,,.._.,,.,,

WNW mﬂmwﬂ,

_,

.

,4,‘

m

V

.

«1w.

,

_

__

v

,

iw'wm

.

’

_

,.

'

July 10, 1970
Mr. Joseph

Lelyvald

The New York Times
229 was: 43rd

New

York,

New

Street

York

Dear Mr. Lelyveld:

I was pleased to have the opportunity today to continue our
conversation, although, I must admit, that I was distressed by
the turn of events.
of the June 4 meeting on Mucous Antagonists in
Opiate Dependence is enclosed, with s list of participants. This
summary has been accepted for publication in Science.
The summary

We

have been

notified by representatives of the

Endo

Division

of DuPont — Mr. Joseph Conlon, Vice~President of DuPont and two
associates — that they would no longer support studies of naloxone
in the therapy of opiate dependence; specifically, they would not
approve studies under

tion) before the

clinical trials.

FDA,

their

IND

(Investigational

nor would they

make

New Drug Applica—

supplies available for

I indicated that we were prepared to purchase a supply sufficient
for our immediate needs, 6 kilograms, at an approximate price of
$10,000 per kilogram - a price suggested in 1969 by Mr. David Kline

of Endo Laboratories.

since

,um‘u

"W”,hwm‘

”new: rnmmm-qvvv-mqu-"w-,m-.-.._.....,

a

.

it

was

Mr. Conlon asked us

unlikely that they

would honor

Our request was sent today, and a copy

copy of a

not to

it.

make

this request

is enclosed. Also, a

letter sent to other participants of the

June

4

meeting.

is to obtain supplies of naloxone for clinical trial.
either Endo or DuPont in their une
Any
decision.
help
you can give us to attain our primary
fortunate
be
that, we will cooperate fully
Failing
appreciated.
goal will
American
Our aim

We

have no need to embarrass

to make the complete antagonist story available to the
press - a story with many strange and sordid elements.

�~2‘

Hr. Lclyvnld

hnvc 1130 brought this issue to tho attcntton
CBS Noun, a friend and follower of our work,
havc Icrvcd an ad hoe consultant: on nu-crous occasions.

Incidcntclly, ﬂ!

chll

of Mr. Burl
and for whom

v.

of

Thluk you in advance for your holp.

Sinccrcly yours,
Pink. M.D.
Professor of Paychiatry

Max

ﬁrzkt

July 10, 1970

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                    <text>"wamw

\\

‘gv-I-

‘w

wwwmmwvv

-

~

July 10, 1970

‘

Dr. Leah Lehrer

Consultant, Hospital Programs
City of New York
Department of Hospitals
125 Worth

New

York,

Street

New

York 10013

Dear Dr. Lehrer:

for your inquiry of 7/3/70. Enclosed are the
three protocols you requested, and I trust these are sufficiently
descriptive.
I have called our Research Administration, and Mrs. Lasker's
response is attached for your information. Perhaps Mr. Constantine
can be instructed to send the material as complete as submitted, and
Thank you

more promptly.

Sincerely yours,
;

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

encs.

�"Tu-w ' 'M-w-

V

~—-w—r~ Vwa’avw~—

u...

»»-Ar~"~wi\-

V'HDWMﬁ'Tﬂ/ﬂ'tilwuy ,«vgg-g-u-r. “-7.; vlq‘p'wﬂ

'nr‘wu' »

.imvm-‘m—~...,,...,..(&lt;.--~—.r- Wlﬁ\\_u--ﬂW-qr‘ "4...“.

July 10,

,w.........e.,,.w..,

..

‘3”.‘v‘m ”Wm".

...~

i»...

1970

Mr. John Thompson

Bristol Laboratories
Syracuse,

New

York

Dear Mr. Thompson,

For a number of years we have supported the development
digital computer analytic system for EEG analysis, using an
IBM 1800 central processor. Our programs are of two kinds-- period
analysis and power spectral density. These run in real time and our
outputs allow for a variety of statistical techniques. Our present
approach is to determine drug effects by comparing the sequence of
changes in eny variable after medication by linear regression. Our
period analytic program yields data describing changes in frequency
bands, in amplitude, and in the variability of both; as well as changes
of a

in

first derivative activity.

are able to process 1/2 inch IRIG compatible tape,
300; and will soon be able to process 1/4 inch
using an
IRIG tape. For our collaborators, we deliver either the data of the
primary analyses on cards or magnetic tape; or carry the analyses
through to the final stage using the school's IBM 360/40.
We

Ampex SP

Our recent efforts have been focussed on assessing the
numbered
novel compounds with preseumed psychoactive
profiles of
potential for industry. We would be pleased to discuss.this work

with
so

members

of your research division (although I recollect doing

last year).

Thank you for your inquiry.

Sincerely yours,

.m-unww

.

Max

Fink, M.D.

Professor of Psychiatry

mf/

v

.

.._, your”,

V,

0.. ,.
,

�</text>
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                    <text>rs—nynmvuw

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mr

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up“ r,‘rw

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r
.

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w-

July 11, 1970

Peter Halasz
Budapest, Hungary

Dr.

Dear Dr. Halasz,
Dr. Volavka and I have reviewed your

credentials. I plan to

be in Prague

August 10 to 15, and am staying

If

letter

and

at the C.I.N.P. meetings

from

at the Parkhotel.

you can arrange to attend the meetings,

us an opportunity to discuss the programs of

it will

this Department.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

give

_

7,

”rm”,

»

--:v»-,_ hvaJI-"m‘ldrgwu

,2

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                    <text>Iv:'-IV\raax‘.-VI7'

ma "fair."

u. v.-

v,

'I‘h‘ ..._

“qwmv

.3.

,w aw”-

-.

{levymvhwwynwg—‘m".»m~.‘l-; Inl'l’.!'l""~

;-

,.

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,

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“y‘awam-‘wmwnna—wm)‘V‘fdlmi‘ﬂswan-I-xev'n'm m—~,~rv..vu-ww.mm—v—

&lt;

u.

.

July 13, 1970
,7..,‘,,..,____‘._..r—.4i-

Dr. Henry

Brill

Pilgrim State Hospital

Box 22

West Brentwood, New York 11717

Dear Henry,
This week we received a contract to collaborate with Dr. Miran
A1 and I are planning to he in Athens in mid-August
to arrange the details of the study which will be carried out

in Athens.

this fall.

I deeply appreciate your suggesting this study and your
recommendations, which assisted us in the negotiations.
Our studies of cannabis are progressing well. and as soon as
the reports are written, I will send copies to you.

_

§

i

I would also like to tell you of an unfortunate development
in the studies of naloxone. The June 4 nesting on antagonists.
concluded with an optimistic view that antagonists represented a
meaningful approach to opiate treatment. This week we were notified
by Mr. J. Conlon, Vice President of DuPont and the new leader of
Endo Laboratories, that they were notlonger supporting clinical
studies - neither provide naloxone nor allow the use of the IND.
We have asked to buy naloxone for further trials, but Mr. Conlon
has indicated the request cannot be net. They say the basis for
their decision is the expense of naloxone production; the extremely

;
!

limited world supply of the precursor, thebaine; and the probability
that when the clinical trials are successful, the demand would
rapidly outstrip the supply.
I have reviewed the c.v. of Dr. Shires Hints and have answered
Dr. Karo directly. Unfortunately, both space and funds are limited
for the coming year, until our new facilities are equipped and
funded. In reading Dr. Miura's history, I note his experience
in animal neurophysiology which may be useful to those investigators
with on-going animal studies as Khaaan, weeks, Vikler and Martin.
we would entertain his visit to our laboratory to become acquainted
with our methods.

�-2-

Dr. 3:111

Again.

in Grace...

:1

that:

for your

July 13, 1970

”statue. in «twitching a
“unruly your: ,
Mu:

Pink,

11.1).

Profuoor of Pcychiutry

)4?th

study

�</text>
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                    <text>July 13, 1970
Dr. Msaaaki Karo

National Institute of Mental Health
1—7~3

Koonodai

Ichikawa City
Chiba-Ken, Japan

Dear Dr. Kata:

Dr. Henry Brill kindly sent me the curriculum vitae of
Dr. Shires Miura. I note with interest that he has extensive
EEG

experience, particularly for research purposes, in implanted

electrodes in cats.

We would be pleased to have Dr. Miura visit our laboratories,
and would give him the opportunity to meet our investigators, who
can discuss their work. Our focus this year is in the quantitative

assessment of

EEG

changes following heroin, methadone, cannabis

and various psychoactive drugs.

Our methods

are primarily period

analysis, using a digital computer analytic system.

We have no facilities for animal studies, and suggest that
Dr. Mints could obtain a profitable experience with Dre. W. Martin
(Lexington), Khazan (Mt. Sinai, N.Y.) or Collins (Upjohn Co., Kalamazoo,
Mich.) - each of whom is doing detailed animal studies.

Unfortunately, Dr. Miura is applying late for a fellowship
and space are already allocated until
the academic year 1972~l973.

for 1971-1972, as our funds

I also plan to attend the meetings in Michigan in 1970 and would
be pleased to discuss our studies at that time.
Sincerely yours,
I‘m Fink, 14.0.

Professor of Psychiatry

M?:kt

�</text>
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                    <text>“(v-e-«nww-l

July 13, 1970
Dr. Richard Rech
Department of Pharmacology
Dartmouth Medical School
Hanover, Raw Hampshire 03755

Dear Dr. Roch,

In Aspen this year, Fred Brunet suggested that a session on
and drugs be organised for 1971. I believe I was supposed
to send you some saterial, and some recent reprints are enclosed.

EEG

Sorry for the delay.
From

active

the point of View of human psychopharmacology, the most
is being done by the following:

work

C. Shagass

I. Itil

A. Kales
C. Pfeiffer

—

-

~

Evoked responses

Sleep EEG
Sleep EEG
Amplitude Integration

Recently, I have become interested in the effects of unilateral
on the EC! process, and we have
observed differential EEG effects which are closely related to changes
in visual or auditory memory tasks. .This type of study, in animals
and nan may also be of interest to the participants of the Aspen
and

bilateral electrode placement

sessions.

Is there anything that needs doing in September/October? [I
away in August.]

will be
My

best regards.
Sincerely yours,

5

Fink, H.D.
Professor of Psychiatry

wnwr:

Max

mam-nu:

r
.-

w-v..-e~

Mr:kt

,v

cc: Dr. F. Brunet
BBC e

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                    <text>July 14 , 1970
Dr. Marvin Perkins

Chairman, Planning Committee
Third National Conference Methadone Treatment
National Association for the Prevention of
Addiction to Narcotics
250 West 57th Street
York, New York 10019

New

Dear Dr. Perkins:
Dr. Freedman has left for his holidays, but before leaving,
asked that I communicate our suggestions for the Third Methadone
Treatment program.

duration of action and means of extending methadone's
useful topic. Comparisons with other treatments,
the
narcotic antagonists, would provide an appropriate
particularly
Tho data on
may be a

action

contrast.

Sincerely yours,
Fink, M.D.
Professor of ?sychiatry
Max

Mszt

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                    <text>July 16, 1970
Miss Deveede Ross

c/o

New

England Medical Center

171 Harrison

Boston, Hessachusetts 02111
Dear Miss Kass:

I have reread your letter of July 2, and in the light of
your illness I would like to recommend the following.

3"
‘
-'

I have reviewed the combination of sick time, vacation
of 17 days, and overtime due you and find that your first day
of work is September 8, Tuesday, the day after Labor Day.

.

“v

Inn-:uvw"

5
1m

In the event that you decide to start your schooling I suggest
that you call my office at least a week ehedd of time.

‘3‘

'm-wmwvnu

I trust that you will be
work
to
on September 8.

V"
1‘»

7.

'/~‘M~'W1&gt;'s“m"",'h

sufficiently recovered to return
Sincerely yours,

J.»

,.,~;

,y;.-

Fink, M.D.
Professor of Psychiatry

Max

w],

.

en...”

~’
:20:

's"-'.?=

"Maintain,"

emvnr'Wv—m-Lv

~'

"-wwmmrw-vmru

Tm;

?

�</text>
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                    <text>July 14, 1970
Dr. Thomas Williams

Clinical Research Branch,

Room 10Al9

National Institute of mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear Tom,

I visited Martin Kat: late last month, he told me that
Con~
you were returning to head the section on depression studies.
success!
wishes
for
and
best
your
my
gratulstions,
When

studies of ECT are progressing well. We have completed
the first study, s comparison of unilateral and bilateral HOT,
and found that unilateral electrode placement provides less
memory loss, less EEG abnormality (with non-dominant accentustion)
but, alas, less clinical ”improvement" as well. The data supports
Our

our

ECT

hypothesis of 1961 and 1966.

have begun MMECT, and in our pilot studies, confirmed the
only for unilateral electrode
feasibility of the techniques, not We
well.
are monitoring oxygenation with
placement, but bilateral as
EEG
during the seizure.
and
continuously
the
ear lobe oximetry
We have improved our techniques so that we are ready to undertake
a more definitive study in the fall.
We

,

._

..

“s
".1

.
,__._

.
:5,

"My“,

,4

-ms-Wu;.n.,-.,,

w-

“W‘FI-‘m-‘mem

discussed, there have continued to be some problems
in patient control at Gracie Square Hospital endows are now
negotiating for beds at Kirby Hospital (division of Manhattan
As we

State Hospital). This issue should be clarified by mid-September.
We have also begun some CSF collections and measurements,
collaborating with Alex Ksroznar of Loyola University, who is
willing to do the neurohumoral assays.
I am writing, however, not only to give you a progress report,
but to suggest that the time may be appropriate to call a meeting
of the scientists working in ROI and in memory, to review the
impact that unilateral electrode placement has on our understanding
of brain function, memory and behavior. My associates would
like to organize such a meeting, and would like your collaboration.
The meeting would
A tentative list of participants is attached.
and multiple ECT and memory mechanisms, with
from
chemistry and neurophysiology. The questions
contributions
of memory functions and the impact
localization
of concern: the

focus on

unilateral

of seizures, repeated or single; the possible alternate routes
of behavioral change with less memory impairment; and, the biochemistry
of seizures and their relation to memory mechanisms.

�‘-

era-czar?“

rr

Dr. Williams

-2-

July 14, 1970

Such a meeting could be held independently or in conjunction with
another society, as the Aspen Brain Research series (held in January).
We would be willing to contribute
substantially to financing the
meeting. It may be possible to generate an interesting volume on
ECT

in such a meeting.

martin suggested I send you these thoughts. As I will be away
would like to invite you to visit us in early September,
to discuss this meeting and to review our ECT program.

in August, I
Again,

my

congratulations on your

new

mission.

My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc: Dr. Katz
J. Shields
enc.

best regards.

�</text>
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                    <text>it
mm:

“‘Jrﬂﬂ'

July 15, 1970
Dr. Michael Taylor

Oakland, California
Dear Mickey,
Thank you for your letter of 24 June. I do understand
reluctance
to join the V.A. My recommendation was based on the
your
of
the
next few years~» shortages of funds, etc. —~ and the
realities
awareness that the V.A., being a lumbering giant, will change slowly.
It will provide funds and space and patients.
'

relationship to Kirby is progressing very
in
(Irv and I wrote it) and Dick
is
negotiation
contract
I visited Kirby today. The Metropolitan wards are understaffed

well.
and

The

However, our

but there are patiente,space and we will have the reaponiihility for
their care. I am sure we can work something out there within the
next few months.*
The report on lactate still stimulates interest. Our
idea of using the lactate test as an index of anti-anxiety drug
effect is now under trial at Pfizer laboratories. They are setting
up an experimental unit in a prison in Connecticut and will try
the experiment there. They are also planning to use our system to
analyze their EEG records. I suggested they not try their own compound
alone, but compare it to an accepted standard.
Have fun

in California.
Sincerely yours,
Max

Fink, N.D.

mf/

will have a position and salary, commensurate with
your experience, at either Kirby or MBCMHC. We will work out the
details in the winter. (Salaries are changing so rapidly, and the
structure at Kirby and at HHCMHC are too diffuse to make a firm
offer now-~ but I am sure we will find a basis for your continued study here.

* Assume

that

we

�</text>
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                    <text>July

16 , 1970

The Honorable William G. Milliken
Governor of Michigan

State Capitol Building
Lansing, Michigan

Dear Governor Millikan:

I am writing at the suggestion of Mrs. Donald A. Blonquist,
869 Canterbury Road, Grosse Pointe Woods, Michigan 48236, who
asked that we
you of our experiences with naloxone.

tell

met

Scientists experienced in the treatment of opiate addiction

at the

New

York Academy of Medicine on June 4.

They concluded

that narcotic antagonists, particularly naloxone, was the most
interesting new treatment of opiate dependence. They suggested
a number of lines of investigation ~ including the development of
a long acting form and additional clinical trials. A summary of
the proceedings of that meeting is enclosed.
Unfortunately, naloxone is produced by a small division of
On July 8 they indicated that their support of naloxone
would
research
cease because the promise of naloxone was so high
that they feared that they would be unable to meet the public

DuPont.

demand.

a reported of the New York Times called DuPont, they
became sufficiently concerned to temporarily resound their decision
and indicated that they would make supplies availible only to the
When

present three clinical investigators.

I trust that this information is useful to you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkt

enc.
cc: Mrs. Blomquiat

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                    <text>July 16, 1970
Dr. Everett Elliuwood

Duke University Medical Center
Durham, North Carolina

Dear

Everett,

It was kind of you to invite me to contribute to the
volume on amphetamine abuser I would like to do so, but would be
unable to give the project any time until after the trip to Europe.
If you mean for the fall, I will do my best. If sooner, you may
wish to ahk one of the others.
I trust I will see

you

in Prague.
Sincerely yours,
Fink, M.D.
Profsessor of Psychiatry

Max

mf/

�</text>
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                    <text>July 16, 197°
Dr. Lois Chatham

National Institute of Mantel Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015

Dear Dr. Chatham:
Dr. Freedman and I have reviewed the Narcotic Addict
Reporting program forms, and believe that our participation
in such a record keeping activity wotld be useful.
How

many

in participation established?
thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
..

.w

awn)V'-'.‘r~""_"-w;“wr‘.-rﬁv&gt;

o

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w.

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�</text>
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                    <text>...

”curvy;

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.

n.

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w

&lt;

m

,_.. I'tﬁf&lt;'lw—)"¢ up

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.

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v

July 16, 1970
Dr. Allen P. Berger
Chas.

Pfizer

&amp;

Co.

Groton, Connecticut
Dear Allen,
A

Enclosed is a corrected version of the cidoxcpin study.
small addition was made on page four.

I find that Dr. chtanaga will be able to start the study
in August 1‘ the supplies are available now. we have asked for
10 mg capsulca, and matching placebo. tau you make 1000 of
each cvailable?
Sincerely yours,
.
at
'v
"or.

"r“,

Fink, 14.1).
Professor of Psychiatry

Max

r-wrr

""1

MP:kt
one a

MM;

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.

.
.—

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5.5,;

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-:

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mm

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,
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...,.. ,,

.

.. ,

�</text>
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              <elementText elementTextId="44423">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>"r"!

nv-xnm-r-v

.
.v-_-.-

70“....

',;r-vv-v&lt;

mun-

.:

,w»vr;«rxmavrram

July 17,

:x-u

w

1970

Dr. E. N. Terry, M.D.

Medical Director

Pharma—Research Canada, Ltd.

Montreal, P.Q.

Dear Dr. Terry,

I have received and read with interest the descriptions
of PR—F—36-Cl, Ko 1313, and Ko 1366. The laboratory data describes
these compounds to have significant adrenergic blocking activity.
The evidence for central nervous system activity is slim, and it
would be of great interest to investigate compounds of this activity.
We are now studying propranolol and will
begin a study of PCPA

this

summer.

The brochures lack and reports of single triils in
these been done ? If so, may I have an opportunity to
review the single dose behavioral and laboratory data ?

man. Have

reports,

Thank you for the opportunity of reading these
and I look forward to discussing them in greater detail.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

mf/

�</text>
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July 17,

1070

Dr; Charies Shagass

Eastern Pennsyivania Psychiatric Institute
Henry Avenue and ﬁbbottsford Road

Phiiadeiphia, Pennsyivania
Dear

Charlie,

EncloSed is a copy of the appiication for a
study in Greece as submitted on August 12, 1959.
pleased if you would assist us.
I look forward

hopefully, Greece.

feasibiiity

I would be

to seeino you in Prague, Istanbui, and
Sincerely yours.
Max

Fink, “.9.

Professor of Psychiatry

MFtkt
enc .

�</text>
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                    <text>July 17,
Ampex

1970

Corporation

Hackensack,

New

Jersey

Gentlemen:

Please repair the enclosed amplifier for
Serial #15l728, Cat. lOO5lZ~080.

Bill:

SP-SOO,

Fink. M.D.
Department of Psychiatry
New York Medical College
5 East lOan Street
Max

New

York,

New

York l0029

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MFtkt

�</text>
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                    <text>H,

..

u

Wyn-Kw.‘

July 17, 1970
Mr. John

Director,

Ingersoll
BNDD

Department of Justice
Washington, D.C.
Dear Mr.

Ingersoll,

For more than four years, we have been using
diecetylmorphine (heroin) in our studies of the role of narcotic
antagonists in the treatment of opiate dependence. Because of
existing regulations, we have received our supplies from the
Department of Justice on an informal bases.

requested an additional 10 grams of
were assured that our request would be
recrystallized heroin.
filled. It has not been to date.
In March,

'wrrm-nwww‘"

We

supplies for study purposes is exhausted, and
I am writing to request 10 grams of recrystallized heroin for research
purposes—- purposes which are in the national health interest. This
work is supported by funds of the New York State Narcotic Addiction
Control Commission, the national Institute of Mental Health, etc.
.

“

we

Qur

Thank you.
"WW-Um"

Sincerely yours,

v
3,
"2w,

um

v

Max

mf/
av

'VEI-rv

,

Fink,

M.D.

Professor of Psychiatry

-~m&lt;~»:awwvwwrjrmrmw&lt;

�</text>
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                    <text>rw—wn.vs“

'w—u

-wrb~w‘wwxvv'wm¢iwrwmg

_

,»

,

_

,

"an”

“.7 ., .7..,......w..,.

.-- p. “cw-wuu.

mmy

~V‘W-

_‘—.—_—m—Wr_c~m

7...“...

,. m...

._~-~

..

van-«w

I-Imwﬁw

Fe

ww-

.m

Fwy-,1.”

y...

v-

....~&lt;~

1

ayw_,'11-vL—W‘ﬁ'vawrw

.1-

nrﬁyrrnv-“WWJWH

July 17,

1970

Miss Eileen Milling
PRA

210 East 47

ﬂew
Wamvwmmrmmwrmmwrwwr

Street

York City 10017

Dear Miss Milling,

In response to your request, enclosed is a summary
of a special meeting, convened on June 4, 1970, to review the
available data on the use of Narcotic Antagonists in Opiate Dependence.
-'.'"{&gt;".2

rg—mem

y.

:

E

-

of this ﬁepartment is under the personal
M. Freedman. He is Professor
of Fsychiatry and has been chairman since 1960. He has supervised
a narcotic addiction treatment and research program in the Department
since 1961.
The work

direction of the

Chairman, Alfred

I joineddthe program in 1966, and am Professor of Psychiatry,
and Director of the Division of Biological Psychiatry.
we

have accommodated requests such’as yours, making

available the resources of our center as the project may require. In
each instance, particularly with profitnmaking concerns,or agencies
operating under reimbursement contracts, our fees are negotiated in
advance. I would be pleased to discuss your program with you before
August 1, or you may wish to negotiate with the chairman after September
1.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.
.

mf/

.

�</text>
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.wv W

T

.V.

..

.,

July 17, 1970
Dr. Allen P. Borger, M.D.

Dept. Clinical Research

Pfizer

&amp;

Co.

Groton, Connecticut 06340
Dear Allen,

of

Doxepin,

7/15/70.

a draft protocol for the EEG Profile Analysis
Comparison of Pamoata and I101 Fomulationo, dated

Enclosed

III:

is

In reading the initial human data, it seems that the
reduces
the rate of absorption, and we are projecting an
pamoate
extension of the duration of each drug experience to 3 hours, rather
than the 2 hours we found sufficient for oral doxepin (3C1).

the time you read this, I will have tried to reach
meet on Wednesday afternoon, if possible; or
you to ask that
another afternoon later in the week.
By

we

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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July 17,

1970

Dr. Ivan K. Goldberg
New York City
Dear Dr. Goldberg,
1....-

.r.

qua...

Thank you for your kind invitation to participate
in the development of the Behavioral Science Library. I regret that
my present commitments already overwheim me, and I would not be able
to give the project the attention it deserves.

W.«Wm~.w.——r..~r_.wn-”

—.-:vaw‘.w

May

I suggest that other

members

of this Department

be in a better position to contribute, especially Drs. Arthur
lake and Richard Resnick, on the subjects of treatment of opiate
dependence by narcotic antagonists; Dr. Jovan Simeon on the treatment
of outpatients with psychotropic drugs, and the special problems
of the use of drugs in adolescent behavior disorders; and Dr.
Richard Abrams on the comparisons and applications of unilateral
and bilateral convulsive therapies in the treatment of depressions.

may

Good luck

u-memee.w-ww

!

Sincerely yours,
.u.

Max

‘m-mw—mmr—

Fink, M.D.

Professor of Psychiatry

mf/

.—D

‘i

�</text>
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                    <text>w. ‘—

July 21,

_,

.-.,

1970

..

Mr.

.‘nVr

am

up,"
.

an

m.—

o
v

Earl Ubell

CBS-TV

51 West 52nd

New

York,

New

Street
York

1:11-‘wwv-p

.

.

e

w.

u

Dear

‘
.

mm,

'
WW

*V"
—w

”Hr-m

Earl,
I want to personally thank you

W»

for your assistance

and

advice in continuing the study programs of naloxone in the
treatment of opiate dependence. Your suggestions were most
helpful and your inquiries at DuPont served to communicate
to that organization the public importance of this program.

pleased to enclose a copy of the letter I received
today from Mr. Jerome Serchuck of Endo confirming the reversal
of their decision and their continued support of this program.
I am

"MM.IWHV'II

"an".

un-unlr-Rlv‘m,

,1",

Incidentally, I watched the first installment of your
new series on drugs. It was well done and I hape that the
one. I
rest of the series comes across as well as the first
kind
refer~
the
thank
for
indeed
you
am embarrassed, but must
ence to

My

,‘qu’wr'ewﬁ-ﬁ

my

participation.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszt
enc.

�</text>
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                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics

80 East Concord

Street

Boston, Massachusetts 02113

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

thet the
in
published
§c§g§gg.‘
You know

summary

much

of the proceedings are to be
’

Also, I am sure you heard that ﬁnds (ouront) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the Week the edict was rescinded.
Supplies are assured for 1 year was reported-by the New York
Times (July 14).
—

~

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, ”.3.

ProfesSOr of Psychiatry

MP

:kt

one.

�</text>
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                    <text>-

.1

'1,

--..n—~A,~....«

mr-Ww-Vwam—rn

ransom

”2:15"

"rw

July 21,

'w'r

.1“:

1970

Mr. Jerome Serchuck, Vice Pres.
Bndo Laboratories, Inc.
1000 Stewart Avenue
Garden City, New York 11530

DW-a'ﬁzuﬁm

mn'r'rrnpum

or“,

Dear Mr. Serchuck:

TJ‘J'SW

Both A1 Freedman and I thank you for your prompt reply and
favorable consideration of our request to continue supplies of
naloxone for clinical trial in the treatment of opiate dependence.
The proposed supply

of

6

kilograms of naloxone,

3

kilograms

by November 1, 1970 and 1 1/2 kilograms each by December 1, 1970
and January 1, 1971 is satisfactory and will permit us to undertake

our present

clinical assay.

We have discussed with Dr. Jacobson the formulation of naloxone
and he has assured us of his coeperation in providing the supplies in
either tablets or liquid vehicle, as most feasible for the study.

On behalf of the College and the New York State Narcotic
Addiction Control Commission we are indeed grateful that you are
considering supplying this at no direct cost to the people of the

State of
on

.

New

York.

My personal thanks for your cooperation
behalf of this program.

and sincere

Sincerely yours,
mawr{mm.xrw.w

Max

Fink, M.D.

Professor of Psychiatry

“1r-":w=-vmmmvzwm'“wf’w

'1'":

‘W

WWW)?”

we

m
‘

MF:kt

efforts

�</text>
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                    <text>July

21 , 1970

Mr. Joseph Lelyveld
New York Times
New York, New York

Dear Joe,

this opportunity to express my personal
thanks for your assistance and efforts in reversing policies
of Endo Laboratories in the production of naloxone. Your
inquiries served to alert DuPont to the public health importance
of this project in a way that we could not accomplish.
I want to take

vp.-v-r"-V

v-

WW.“

wry-7*

n

p,“

Enclosed is a copy of a letter I received from Mr. Jerome
Serchuck of Endo Laboratories, confirming that they will supply
naloxone for the next phase of the clinical studies.
My

thanks for your fine

article

and your

assistance.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
811C .

....Y

‘.
.

~

-;.

.v-«m

“n"r'L-ur'CSQ‘IF'YI

)axwzmlmrvnnv

I"

,.
r'J'FI'!

writ-9‘

FWI‘Wﬂ'ﬂr—vz“

�</text>
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ww—u-

.m..,..«.—,.-...

..,

."w

"1w,“

__

&lt;

July 21,

1970

Dr. Albert Kurland
Spring Grove State Hospital
Baltimore, Maryland
Dear Al,

efforts at reversing the policies of Endo Laboratories
have been successful. Enclosed is a copy of a letter which I
received from Mr. Serchuck confirming this change.
Our

Having survived this crisis, I do believe that it may be
useful for us to continue our informal communication so that
we can be prepared to deal as effectively with future reversals.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>July 21,

1970

Dr. William R. Wartin

Chief,

MIME

Addittion Research Center

P. O. Box 2000
Lexington, Kentucky 40501
Dear

Bill,

release form of antagonist is
13
of
clear.
letter July describes some steps which may
be necessary to test the feasibility of Sr. Yolles’ preparation.
The need

Your

for

a sustained

Al Freedman is in Europe and I am leaving on August 4.
and I will both be together again in ﬂew York after September 3
and I would suggest that we arrange to meet - with Dr. Yolles and
any other interested participants ~ during the second or third week
in September. This can best be arranged on our return.

He

you are aware that Endo Laboratories on
announced
decision to discontinue supplies of naloxone
a
July
for clinical trials. In re5ponse to inquiries from friends on
the New fork ftmes and CBSeTV, Dupont reversed their decision
and our clinical programs, despite the improhanility of its
success, will continue. A copy of “r. Serchuck‘s letter is

Incidentally,

3

enclosed for your interest.
My

best regards.
Sincerely yours,
Wax

Fink,

M.D.

Professor of Psychiatry

MF:kt
811C.

�</text>
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                    <text>v.
—,

A,

,—

wmyv

July 21,

1970

Mr. G. G. DcAngelis

Director, Special Communications
Pfizer Pharmaceuticals
235 East 42nd Street

New

York,

York 10017

New

Dear Er. DeAngelis:

for your letter of July 14. Cepies of the face
curriculum vitae are enclosed.

Thank you

sheets of

my

For announcements, the proper designations

are:

Dr. Max Fink, MA).

Professor of Psychiatry and

Director, Division of Biological Psychiatry

Department of Psychiatry
York Medical College.

New

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>w—p.

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July

1m,

www
_

22 , 1970

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

is our

You know

that the

check as reimbursement for expenses

the June 4 meeting on narcotic antagonists.
appreciate your participating.
published in §gienge,

summary

I very much

for

of the proceedings are to be

sure you heard that Endo (PuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility“,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a pleasant summer.

Sincerely yours,
Max

Fink, M.ﬁ.

Professor of 9sychiatry

MP

:kt

enc.

�</text>
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FYWQV“

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.

valw-'

»

wr&lt;.\--.

1m-‘——V.v,vrwr“—r_'rnu«-

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U

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unw-

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‘Yﬂ'

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v.

r

July 22,

1970

Dr. Sarnoff Mednick

Street

2 Perry
New York, New

York 10014

Dear Sarnoff,

Stanley Feldstein recently brought to my attention his
failure to request a honorarium for your visit to us, too long
ago. Please accept my personal apologies for we did not usually

Operate

this

way!

thanks for your lecture, and
continued success of your program.
Many

my

best wishes for the

Sincerely yours,
Max

Fink, 54.0.

Professor of Psychiatry

MF:kt

enc .
.

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3J4!"

WUJ‘JMFA

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A.

4

,

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I"ua-~' . .«u “v. mw-vvvw-v-

»- v

vwmvr-r

w

y. .nmm.a._—~..V".—r*WWV~V§~‘FV.m——,*WLKAV , ‘vr.n.-Y'.-~,VJI=V

Wynn”... ._.. "a.

w ”p-

w.“ w:

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July 22,

&lt;.-,,-,..

1970

.-

'a-rw

Ina-2v"

w‘mwwnww-r

“WI?

-

“xv-yrswr‘nvn

Dr. Louis S. Harris
Department of Pharmacology

University of North Carolina
School of Medicine
Swing Building
Chapel Hill, North Carolina 27514
Dear Lou,

Enclosed

urn-t

mn-wmw:m~‘u4~rzrnnﬁwv

check as reimbursement

that the
Science.
in
published
You know

for expenses for

summary

much

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone fer clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

mﬁ-‘l—HHHYWH“'mzwr1aﬁs‘n‘uV.-

is our

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.

My

7"mM'vvrnv'c

am

best regards for

a

pleasant

summer.

Sincerely yours,

'I'

wu'zm-‘w'

”ﬂ

r-vv,

Max

w

raw-mime»

‘j’

Mpzkt

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”rum

-

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K‘Oim-ﬂ.

Fink,

M.D.

Professor of Psychiatry

enc.

.u

m...”

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�</text>
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                    <text>July 22,
Dr. Jerome H.

1970

Jaffe

Department of Psychiatry

University of Chicago
950 East 59th

Chicago,
Dear

Street

Illinois

60637

Jerry,

Enclosed is our check as reimbursement for expenses for
the June 4 meeting on narcotic antagonists. I very much
appreciate your participating.
You know

that the

published in Science.

summary

of the proceedings are to be

sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial ”responsibility”,
called DuPont and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
Also, I

am

—

My

best regards for

a

pleasant

summer.

Sincerely yours,
Max

Fink,

35.2).

Professor of Psychiatry

HF:kt
enc.

�</text>
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                    <text>-m mr—vmv.W

mwl"-IWW—nw—m

July 22,

1970

Xerax Corporation
295 Madison
New York, New York

Attention:
Dear

Mr.

Saratella

Sir:

Please make six cepies in reduces 3 1/2 xrll of our
records marked ”onepin 0ra1 Study”. Please collate.
Please

bill

me

at the

above address.

Sincerely yours,
“4.3.x

Fink

’

:1. r)

0

Professor of Psychiatry

HF:kt

wwwl‘qw—‘W

�</text>
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                    <text>July 22,

1970

Dr. Joseph Cochin
Boston University School of Medicine
Department of Pharmacology and

Experimental Therapeutics
East Concord Street
Boston, Massachusetts 02118

80

Dear Joe,

Enclosed

is our

check as reimbursement

for expenses for

the June 4 meeting on narcotic antagonists. I very
appreciate your participating.
You know that the
published in §gience.

summary

much

of the proceedings are to be

Also, I am sure you heard that Endo (DuPont) on July 8,
cancelled further supplies of naloxone for clinical trials.
We protested, without avail, until our friends on the New York
Times, hot on a remarkable story of industrial "responsibility”,
called DuPont - and within the week the edict was rescinded.
Supplies are assured for 1 year was reported by the New York
Times (July 14).
My

best regards for a pleasant

summer.

Sincerely yours,
Fink, 32M).
Professor of Psychiatry

Max
HF

:kt

enc .

�</text>
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                    <text>July 23, 1970
Dear Turan,

Skiing in January

?

Richard Roch of Dartmouth called to invite a program
group in Aspen for 1971. I suggested that
would
be
pleased to present your findings on the EEG effects of
you
psychoactive drugs on the sleep EEG. The focus is on the correlations
of EEG in man and animals. He is inviting Wallace Winters and himself.

for the Brain Research

923WL

‘57

.

Vim"

I suggested that Charlie Shagaas present data bridging man and animals;
I would do the awake EEG and would you take the sleep EEG ?

"5‘51“:

m7

The focus could be the

effects of indole
The

4ms=rmw

and

hallucinogens, particularly the

anticholinergics.

date: January 18, 1971

Meeting dates: January 16-22, 1971

r-v-

'v

Place: Wildwood-at-Aspen

(I will

be taking one or two of

my

See you in Prague and
My

children. ﬁring

Kurt and

Istanbul.

best.
—Sincerely yours,

Max

Ellen.)

�</text>
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July 23, 1970
Dear Charlie,
How about skiing in Aspen in January ?
As hot as
and on the eve of holidays in Europe, it is time to think of the

ski season.

Richard Rech of Dartmouth has been asked by the
organizing committee of the Brain Research conference group to
organize a session on BBC and drugs in animals and man. He is
inviting willace Winters and himself; I suggested that you and Turan
be invited as well.
Would you care to discuss the EEG studies in man and
animals, their correlations, similarities, etc. ? He would like
to focus on the theories of EEG and behavior (association, dissociation)
and your mission, if you accept it, is to bridge the gap between the
animal workers and Tursn and myself.

Date: January 18, 1971
Meeting: January 16-22

Place:

Wildwood—at-Aenen

~r

-

-:»-:~v

‘(

See you in Prague.

“1...“:[2'

U'!"f'ﬂ’lrﬁi&lt;'f:5'l

-

.1'17&lt;

0.1

"a:

n-

an.

guyrmwu

it is,

Max

�</text>
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                    <text>5,.

n
V

W’Whjﬂ'.m1rn

July 23,

.
.y;

1970

raw

01"

Dear Dr.

Briét,

warm-”’3;

I have received your

"NWT/"Ll!

,
7.»,

LM‘M'YW“

r-

letter enquiring

about a

position in the Department of Psychiatry to study computer
applications to electroencephalography. Your suggestion interests
us, and I would be pleased to discuss it further.

,._,

wan-,mvﬂyz

«w:

Conveniently, I plan to be in Holland early next
that you plan to meet me to discuss your
questions. I will be in 089 from Thursday, August 6 to Sunday,
August 9 and will be staying at the Motel Nuland. It would be
best for you to call my host, Dr. Peter Fell at Organon
in 053 (04120-8433, and explain that you would like the opportunity
to meet me at a time most convenient to Dr. Fell and the party

month and I suggest

at

Organon.

Sincerely yours,
Vt:

’mr

Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>MAILED

T0:

DR. DOROTHY DOBBS

1600 s. Eads
Arllngton, Virginia 22202St . ’ Apt'

432N

_

July 23,

1970

Dr. Dorothy Dobbs
Section of Neuropharmacology
Food and Drug Administration
Washington, D.C.
Dear Dorothy,

It was a pleasure talking with you today, and finding that
views
on the proposed guidelines for drug evaluations were
our
essentially in agreement, reassured

me.

Thanks.

Enclosed is a copy of the summary of the June 4 meeting on
Narcotic Antagonists in Opiate Dependence. It will be published
in Science. The participants included clinicians, pharmacologists
and chemists with experience in the antagonists. We concluded that:
(l) The antagonist model was both clinically useful and theoretically
interesting; (2) Available antagonists, cyclazocine and naloxone,
were safe and further studies should continue; (3) A long-acting
antagonist was the ideal immunizing agent and every effort should
be made to enhance such a development.
We are continuing our clinical studies of cyclazocine; have
been reassured (after much difficulty [see New Yerk Times, August 14])
of our supplies of naloxone for one year; and have contract support
from the New York State Narcotic Addiction Control Commission to
develop a long acting antagonist. (We also are continuing a methadone
maintenance program and are studying the duration of L-alpha—acetylmethadol,
using heroin challenges as our index of duration of cross—tolerance.)

FDA

It

would be an honor, and

committee program.

There

interesting, to participate in the
is surely need for continuing evaluations

of the methadone and other opiate treatment programs. My curriculum
and I have been cleared for U. S. governmental

vitae is enclosed;

activity.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

enc.

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                    <text>July 24,
Dear

we

1970

Peter,

thank you.

Your schedule for our

visit is

most agreeable and

are arriving in London on Tuesday evening, August
on the day flight. We are scheduled to leave London at 1500 on
KLM 132, scheduled to arrive in Amsterdam at 1555.
We

4

I ask your help in a small matter of concern to
I have received a letter from an applicant for
my Department
a fellowship in our laboratories, Dr. Paul BriEt. I have taken the
liberty to invite him to meet with me during my stay in Holland. If
he calls your office, would you arrange that he and I meet for about
an hour, at a time least inconvenient to you and Dr. Quantock ?
Many thanks.
May
?

I look forward to visiting next month. Martha and the
girls send their best regards.
Sincerely yours,
Max

mf/

fxayg~

Fink, M.D.

�</text>
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                    <text>—

m-vr»

,

July 26, 1970

.N

11-7

a;

urnmw-J

Mr. William F. Buckley,

New
New
"rﬂvnl.ﬁ4'mr‘m

York Post
York City

Dear Mr. Buckley,

I have read your columns with interest and for the
time decided to answer what may have been an appeal. In your
column yesterday, you write that the drug problem is
literally
engulfing us and " not one living soul has suggested a program the
results of which would guarantee a diminution of the curse . . ."

first

There is one program which is nascent and which has
the promise to reduce the addiction rate in much the way that
other immunization processes have reduced the incidence of infectious
diseases. I refer to the use of opiate antagonists in the treatment
of opiate dependence, and the feasibility of developing a long term,

injectable or implantable antagonist which would be particularly
useful in “immunizing" susceptibles, particularly among
the very

we?”

young.

The program

is generally ignored

industry, although there has been

some

by Washington and
New York

support from the

State Narcotic Addiction Control Commission.

written in the press so that the only data that is reliable islittle
in
the scientific press. The summary of the meeting held in New York
on June 4, summarizing the available data, is to be published in
There has been

a forthcoming issue of Science.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>\\

11‘

July 23,

1970

Mr. Robert Marlin

Sandor Pharmaceuticals
New Jersey 07936

Hanover,

Dear Bob,

Separately I am sending you a summary report and statistical
data of our two EEG studies of 8 42,548 in volunteers. In the
reported December 22, 1969, we defined a dose of
first study,
8
4.0 mg of 42,548 as adequate to alter the behavior of our
volunteer subjects.
'
'

NMQ—‘l’ﬁfﬂk

‘JW‘E‘M’E;

w

.-

,
,

Nvi-mu

we"

mm?»

In the second study, reported here, we compared the EEG
profile of 8 42,548 to placebo. While many differences, particularly
in behavior and systolic blood pressure were observed, we were unable

to establish an EEG profile. As we discussed, the failure may relate
to the sample size or dose of 3 42,548 ~ or to the possibility that
its central effects are variable and unsystematic (at this dose).
There are two options that are of interest to us and meet
some of your needs. One is to extend this study by additional

subjects at 4.0 mg or by an additional 6»12 subjects at 6.0 mg,
in comparison to placebo, following this design. This will either
demarcate an EEG profile, or failing to do so, satisfy the
statisticians who may question our sample size.
The second

is to accept this data

and proceed with a

direct

comparison with dextroamphetamine in a larger sample. This compound
was the principal comparison in animal studies. If we define a
profile for dextroamphetamine and not for 8 42,548, we can be confident
that the CNS effects of 5 42,548 are less than amphetamine. Failure
to define a profile for dextroamphetamine will raise doubts as to
our technique.

�-.-

:

'wwvw'wv—w‘mmvm.

z.,——_r.1x'_mu._—nw_,.\. V.‘,.,_.............n. we..-” ,_..

.w

V

.. ..v

”a", ,..-, we- . .._

we

_

is

w:

7

‘—

.—

mew.

Hr. Robert Marlin

July 28,

—2—

1970

rxu'vrv-Wii“

1'Vrtrm“w"w~

(a

Imitasmr

TWVSI'W’V

WWW,“

"'4

ym'r.‘

Before concluding the present study, however, you may wish to
arrange a review of our data with other investigators of 8 42,548,
both within and outside Sandoz Pharmaceuticals. I am leaving for
my holidays in August, and would be pleased to participate in such
a meeting in early September.

statisticians to
their analyses of the data, trusting that their results

I would also be pleased to meet with your

review

are similar (but hoping they find

more

than

we

did).

Incidentally, the study took much longer than I anticipated
Now
largely by our need to improve our statistics and programs. with
that these are fully operational, I am sure we can proceed
greater ease.
My thanks for your cooperation in this study - and my best
regards.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>Tim

C"

',
F,-

a
“a.

“macho,

July 29, 1970
Mr.

Saratella

Xerox Corporation
New York, New York

Saratella:

Dear Mr.

I am sending you seven books of computer data to be
photocopied and bound. As you described, they are each to
be bound on the tap edge, like the data book. As I need
different numbers of copies for each book, please noteza
4 Drug

Stony Regression Analysis

Thiothixene Prolonged Studies

—

~ 5

3

capies

Tniotnixane Study Regression Analysis

-

~

2

copies

Placebo

~

5

copies

PCP 250 mg

~

3

copies

75 mg

~

2

copios

S

GP

4 mg

—

I would like to
possible.

capies
~ 3

copies

have these picked up Friday afternoon

Sincerely yours,
Max

Fink; M.D.

Professor of Psychiatry

MF:kt

,

if at all

�</text>
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                    <text>July 28,
Congressman

M.

1970

Biaggi

of Representatives

House

Washington, D.C.

Attention:

Mr.

Peter Ilchuk

Dear Congressman Biaggi:
In response to the telephone request of Mr. Ilchuk, I an
pleased to enclose a copy of a summary "Narcotic Antagonists
in Opiate Dependence”. The meeting was held on June 4, 1970
and was attended by the principal research scientists working
in narcotic antagonists.
They concluded that continued studies of antagonists are
important, particularly as they represent the principal, logical
treatment method for opiate dependence.

There is need for a more coordinated approach for

study.

this

Should you be interested in additional information, I would
suggest that you inquire of Dr. Bertrum Brown, the Director of the
National Institute of Mental Health, Dr. Peter Grey of the Vera
Institute (who has done an intensive study on this problem for
Mayor Lindsey in the spring), Dr. Henry Brill, Director of Pilgrim
State Hospital (who recommended the support and encouragement
which we are now receiving from the New York State Narcotic
Addiction Control Commission), Richard Severo or Joseph Lelyveld
of the New York Times, both of whom have worked on the problem,
or any of the scientists listed as attending the meeting. It
may be useful for you, on behalf of the Congress to carry on
a more public investigation of this interesting and potentially

very useful treatment of opiate dependence.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MP

:kt

611C.

�</text>
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                  <elementText elementTextId="103319">
                    <text>r,

. ,waV.V—V_,H.._w

.

....

..

.. ......-.... a...

a“. w.~—xW,.V.~—m~_

u-W—rvv"

u—n— w

.—..

any”... ........ ....

..

,,—

--...-.-. 9...”- ....._...__.i..

v"

.

.......,

.

.,.

..v

.

......

7

,

-_

.7.

“m,

.

.V

we

...

.

.

..

~

a
-

Wmv

«

;.s..:-

July 31, 1970

"-mwmwrwmn-

m

'

V'

h

i

E

Dear Mrs . Davidoff,

studies of lactate in anxiety were undertaken last
year, and confirmed the observations of Pitts and McClure. Since
we added very little that was new, we did not see the need to
describe our observations in detail, and simply published a
letter confirming the fact that we were able to replicate the
Pitts and McClure experiment in every detail.
Our

'

Pitts suggested that therapeutic trials with propranolol
we have not undertaken this experiment.

might be tested , but

Unfortunately, this observation is not in the
popular eye and I know of no one in upstate New York doing this
type of work. Dr. Gross of Indianapolis has examined the theory,
and has written a severe criticism.
Sincerely yours,
Max

Fink,

31.13.

Professor of Psychiatry

m

f/

Linda Davidoff MA .

St. Joseph '8 Hospital
symcuse,

New

York

�</text>
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                    <text>'7
""

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0mm

July 31, 1970

"im‘véibmu-‘F‘Usv'ﬁ‘vsvm

,1.
rm

ﬁnger,»

;

ﬁfiss Josephine Baeala
Executive Socretary

NCPS

San Francisco

'x-vmmgz—wv.

:rvgg..gn:-:-z--

Dear Miss Beale,

v7?

:4;

W?

51.2;

wgv

«a

:

'7»:

,-.-»v1-mww’-“ﬂ1wmw

Dr. Michael Taylor is one of the best qualified residants
to have graduated our training programs. He has a brilliant future
ahead of'him, if he disregards the frivolous dbmando of organized

medicine ana ps~zzchiatry.

a resident, he
intelligence above his pairs.
Ag

pleasure to see him assume responsibility for patients and
for nis research projects. He shared the 1989 research priae of
the society for Biological Psychiatry with a fbllom rcaidknt.

was a
m~ww17ﬂxi¥fff

I am pleased

{1552!}

raw-“r

_:ﬁjf’vv‘“

z
i-

AVTJ'.’

initiative, industry and
is sincere and honest and it

showed
He

to

recommend him to the

society.

Sincerely yours,
[jaw Fink,

33!.

Do

Profhaaor of‘Psychiatry

mﬁ/

�</text>
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                    <text>mew—'4‘

"’Ir‘aﬂe‘vwr-«n‘w,"we...

G -‘-4- «mw... W.

,

.7.

————......

m

ww—

7

V

“ﬁrm

«mam-Y

,

in“...

June 1, 1970
Dr. Chris Zarafonetia, M.D.
Univ. Michigan Medical Center

Department of Postgraduate Medicine
Arbor, Michigan 48104

Ann

Dear Chrie,
Thank you verv much for your kind invitation to participate
in the International Centerence on Drug Abuse in November, 1970 at
An Arbor. I am pleased to accept and look forward to the symposium.

the format of the suggested program, I believe you
role of the narcotic antagonists in the
treatment of opiate dependence, particularly in the treatment of juvenile
abusers of opiates. As a suggested title, I would offer Treatment of'
Opiate Dependence by Narcotic Antagonists or the more general title,
Opiate Antagonists and Heroin Dependence.
From

would with a discussion of the

by
M.

In this presentation, the final report will be c0*authored
associates, Drs. Alfred M. Freedman, Richard Resnick and Arthur
Zeke, all of the Department of Psychiatry of this college.
my

Again,

my

thanks for your kind

invitation.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

,.wm

-..v~—.»~an-nmv-

�</text>
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.uwun-grp".

June 2, 1970
Dr. Henry Adams

university of Georgia
Athens, Georgia
Dear

D .

Adams,

my associates and I have read your recent report, ”Electroconvulsive Shock, Brain Acetyloholinesteraee Activity and Memory" with
considerable interest. we would like to become acquainted with any
subaequent studies from your laboratory.

are aware, Ulett and his co-workers were unable to
even with higher dosages of'atropine (oft
Johnoon et al., Arch gen Psychiat., 2:324—336, 1960). In reviewing their
experiences, and our own with various anticholinergic drugs, we became
concerned that studies (particularly in man) that dependeddbn the
anticholinergic effects in the central nervous system were often
unsuccessful because the peripheral effects of'atropine exceed the
central effects, especially at low dosages. While the same is less
true for scopolamine, this compound also has extensive peripheral effects.
we tested a variety of active anticholinergic drugs and reported that
benactyzine, Ditran and diethazine seemed to elicit a higher degree of
central activity in proportion to their peripheral effects.(cj2 EEG clin.
As you

replicate their findings,

Neurophysiol. ,

12.- 359—369,

1960) .

time ago, I reviewed the available data on central
and
anticholinergic
cholinergic activity and the convulsive therapy
and
am
I taking the liberty of’enclosing a reprint that may
process,
Some

be

of interest.

Again, our congratulations on a nice piece cf’work.

Sincerely yours,

m Fink,

M. D.

Professor of’Psychiatry
mf/

�</text>
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                    <text>3-...

WWW‘WWTF'

_

Juan

..

at .nm .r-I-uw

T—

June 1, 1970
Dear

Jiri,

returned.

Enclosed

From Vbita,

letter will reach

is a letter I sent

you.

I

some weeks ago, which was

this address and

have obtained

I trust

this

intthe laboratory is progressing very well, and
for many studies we are now in the data analysis phase of our program.
Vbita has reviewed the EEG data of the ECT dstudy, and we have asked
that the records be analyzed by computer to give us better estimates
of the delta activity and the difference between the two sides of
The work

the head.

to complete the methadone data
I have also asked voita should
have computer analysis.
he
and
has suggested that this too
him
be done, and if'we
work
should
asked
that
to outline the
I have
( and I am sure we can) the records will be analyzed this
can do
summer.

it

I

have organized a special meeting of
specialists in opiate antagonists on TEursday. we hope to stimulate
more interest in a long acting antagonist. Al has received a special
contract to develop such a compound and we hope to stimulate some
Al Freedhan and

company

to carry out the chemistry studies.

Kathy has married, and will continue to work as long as
she is able. Stanley and Vbita have developed a good program for
the analysis of heroin effects and I have sent their project to NIMH
for support. we have sufficient funds to begin the study on our own
this fall and I propose to do so, if’only to get a head start on the

project.

lj’all

goes well,

with me to Prague for the
(the Turkish CINP) meeting.

in Europe, for
My

all

I plan

my children and Martha
and
to Istanbul for their
this August,
be
able
we
will
to meet somewhere
Perﬁaps
would be pleased, as would I.

CINP

my

girls

to take

best regards to Marcia.
As

4,,

ever,

�</text>
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                    <text>1——

-w'r-v.rr—

inw'H'u'Imrs-x'

WWW»

1

"rm-w

r&gt;’V£'WD‘I“-W«-R\ﬁ\‘wwuv,W.nn&gt;"vw-1m¢'-‘W"w1u&lt;":wmun"...

a ”Mg.” 7“,...

«

1....

zv—unchv '(‘VI"-u'«.v 1;».qugrmvlw—mvuvhui‘vﬁm

yr ,4”.

June 2,

~...~

n .7.v.‘.--, m." ' wl‘-».

.

.

‘

a,“

..

,7

1.970

Dr. Oldrich Vinar

Psychiatric Research Institute
Prague, Czechos Zovakia
Dear Oldrioh,
Zine to let you know that Prof. K119131013,
the co-chaiman of the symposium on amphetwnines, has agreed to
the proceedings of the synmoaizm and oo-symposium for

Just a

smize
the final Plenary Session.
My

best regards .
Sincere Zy yours,
3;,“ Fink,

4”,. Do

.,_

..

..

.

..

Wm

..

.

.....

V

.

1.

�</text>
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                    <text>-—

nﬁ‘

.

'

"walniwimmwrvmamwmw,Mmm‘n'.

,

June 2, 1970
P. Kielholz
Psychiatrische Universitatsklinik Basel

Prof..Dr.
-

switserland

nWJ-wmlv-V'

Dear Dr. Kielholz,
v‘rlrmw.V'-Mlﬂnlww"rl“uqx—.

Thank you for your letter 01‘2“le 28. I am sorry that
have invited Dr. Ladewig
you misunderstood the program outline.
to present during the symposium, on the topic of “Amphetamine
and Hallucinogen Dependence in Europe", as a joint presentation
with Dr. Battegay. I wrote to him on May 25, extending the formal
invitation of the Program Committee chairman, Dr. Vinar. By now,
he should have received the invitation.

I

xm'm'm

um

.

Wynn-r.

um

n
«Ir-v

vmmm:

to Dr. Vinar indicating your acceptance
I will write summarize
the symposium and co—symposium
to
the
responsibility
of
the
session.
Plenary
at
with you.

I

look forward to seeing you in Prague and working

Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry
"#7

.

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                    <text>June '4, 1970
Dr. Everett H. Ellinwood, Jr.
Department of Psychiatry
Me University Medical Center
Durban, Elorth Carolina 27706
Dear Everett:

I found the session on mtagonists so exhausting that
to attend your session. I am sure you will armamge
for its publication, and I look forward to this (albeit second

I

was unable

best)

was

of attending.

Thanks again for the
seeing you in Prague.

invitatim,

and

I look forward to

Sincerely yours ,
Fink, MD.
Professor of Psychiatry

Max

mfzkp

�</text>
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                    <text>June 7, 1970
Dr. Milos Vojtechovsky

General Secretary, CINP, 1970
Sokolska 31
Prague, Czechoslovakia
Dear Miles,
In making my plans for the visit to Prague, I find that
I have not received a congirmation of my reservation request for
accommodations. I have received your receipt for registration.

Since making my reservation, I have decided to take
wife and two daughters to Prague.
I

my

writing to ahk your help in rearranging my accommodations
bath, for arrival in Prague August 11 and leaving
Prague August 15. would it be possible to ask your secretary to arrange
accommodations for my family?
Would it also be possible to send 3
additional visa forms, for my wife (Martha Fink) and daughters,

now

for

Rachel

2

D.

am

rooms with

(age 14) and Linda 8. (age 12)
Many
My

?

thanks for your help.

best regards.
Sincerely yours,

mf/

Professor of Psychiatry

�</text>
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              <elementText elementTextId="44042">
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          <element elementId="48">
            <name>Source</name>
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              <elementText elementTextId="44043">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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      <file fileId="2690">
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                  <elementText elementTextId="103316">
                    <text>1—,“...

.
,‘

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,..

av“

wi»!!r

n
u

,.
u

5"?ro

w

."v “wider—n

4-.

-.

.lv-q.’;~'-':'-.

"“‘W‘Wﬂur'

i, ,nﬁxr—

. 4..

.m.~.;;uwnv;~x:.m~.~.z.»q-.wamevpuw-ugahqqm.2-,.

as.“

W T... “a

.

awn”

germ

,xr—

—

w ...... g

”r "was.-.“ we“ ”v‘va‘wvr'. ”v

June 8, l970
Dr. Avram Goldsfein

Sfanford University School of Medicine
Stanford, California 94305
Dear Dr. Goldsfeln,
Thank you for The

my

invifafion

To

parflcipafe

pleased
membership fee, payable fo Sfanford Unlversify.

NARCOTIC RESEARCH

INFORMATION EXCHANGE,

and

I

am

in The
+0 submif

will send

As

soon as we have useful

My

+hanks for underfaking +hls imporfanl mlsslon.

manuscripts for disfribufion.

reporfs,

I

you

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlafry

Address of record:
Max

Fink,

M.D.

Deparfmenf of Psychiafry
New York Medical College
5 Easf l02 Sfreef
New York Cify i0029

rr',

we;

�</text>
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      </file>
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            <element elementId="50">
              <name>Title</name>
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                <elementText elementTextId="1">
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          <element elementId="50">
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              <elementText elementTextId="44024">
                <text>Correspondence to: Goldstein, Avram</text>
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            <name>Rights</name>
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              <elementText elementTextId="44032">
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          <element elementId="48">
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              <elementText elementTextId="44033">
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                  <elementText elementTextId="105910">
                    <text>mar.

w»

..
w

v
..-

'umw'“:v1r-

”Vt-0

vux'l-r-mz

-vn.-v-\.r-.

,1

”mu

A

w:

June 9, I970
Dr. Fred H. Johnson
I58 N. Humphrey Ave.
Oak Park, IIIInoIs 60302
Dear Dr. Johnson:

II was kInd of you To send your currIculum vITae. I regref
Thaf we do no? have a posIIIon open In neurology or neuroanafomy.
When

was

In

I

discussed

The opporfunIfy wITh Dr. Nurnberger, IT

for psychlafrIsIs In Tralnlng who were parfIcuIarIy Inferesfed
cIInIcaI psychlafry or opIaTe dependence.

SIncerer yours,
Max

FInk,

M.D.

Professor of Psychlafry
Mszf

�</text>
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                    <text>«ihwwt

now-w

‘-

:

'

..

'

”run—1d.”

V

1mm A-uwr-W'I'Wmﬁmw'wh «yr: WWI-F‘anw’p Hurray. ww‘luc-lnhxy,'&lt; 415‘:' -:

-.

v
A

upmrmq.

.n

-;

June 9, l970
Dr. Michael A. Taylor
9309 Murillo Ave.
Oakland, California 94605
Dear Mickey,

it

was a

pleasure to meet

your psyche in such good shape.

you in

California

and

to find

have had an opportunity to discuss the possibilities
of your returning to New York next July and there are two opportunities
which present themselves immediately. 3A5 you know, the Department
ls expanding not only into the new mental health center (hopefully
by March) but we have established a formal relationship with
Grasslands and the Montrose VA. in addition, we are still negotiating
a relationship with Kirby Hospital (i/3 Manhattan State Hospital).
This last relationship is still in the discussion stage although
each month I hear optimistic noises from Al Freedman.
and

Al

I

relationship with the Hontrose

The

VA

is established and

A

Freedman is Chairman of the Dean's Committee. They have a few
thousand patients, plenty of laboratory space and a clinical
director who is anxious to accommodate research as well as the
school. i have discussed with him the possibility of having
two members of our staff appointed as clinical investigators.

believe that these positions can be funded by the VA, and
bring with them supporting funds for research, as well as a
research status which would be most productive for you and Sob
to continue your studies except for the obvious handicap of
having a small percentage of female patients. The VA population
i

has much to

it for

your work.

enclosing copies of the application outline for the
position as well as a blank l0~2850.
i

VA

command

am

York i think you
should apply for this position by completing the form and sending
me a one page statement of your future plans and ambitions and
F5

one underpinning for your return to

a proposed

research plan (6.09~b«6,7).

New

w

�June 9, i970

-2-

Dr. Taylor

in The even? fhai we are successful, your appoinfmenf To
The Deparfmenf of Psychlafry will be fhe principal appoinfmenf.
This appoinfmenf will no? preclude your participalion in sfudies

a? ofher

affiliafed insfifufions.

would like +0 recommend Two of you for fhese poslfions and
have asked Dick and Bob To fill ou+ similar applicaflons if
i

I

lhey wish.

saw your leffer in The Brlflsh Journal of Psychiafry and
wide awake desplfe The sunshine of California.
see The? you are
I
owe you a dinner and frusf i can deliver The nexf Time we
i

slili

meel.

slill

My

beef regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

MF:kpf

enc.

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rah-rm TH'P-v—V-Ih".--

nun-r

I
‘:

ww‘

u-nw-

'

L

“CW“.

,,,.

.7.

.

‘va

June 9. l970

)1

'x-Mw,

CepT. RoberT Levine
228 Texas Drive
Dyess AFB, Texas 79607
Dear Bob,
lT was a pleasure seeing you in California. l didn'T have
a chance To fly back wiTh Hy Denber so we dldn'T sTop aT Hobbs.

ll

have had an opporTuany To discuss The possibiliTies
of your reTurnlng To New York nexT July and There are Two opporTuanies
which presenT Themselves imediaTely. As you know, The DeparTmenT
is expanding noT only inTo The new menTal healTh cenTer (hopefully
by March) buT we have esTablished a formal relaTionship wlTh
Grasslands and The MonTrose VA. in adlelon, we are sTili negoTiaTlng
e reiaTionshlp wiTh Kirby HospiTal (l/3 ManhaTTan STaTe HosplTal).
This lasT relaTlonship is sTill in The discussion sTage elThough
each monTh I hear opTlmlsTic noises from Al Freedman.
1

and

l

The relaTionship wlTh The MonTrose VA is esTablished and Al
Freedman is Chairman of The Dean's CemmiTTee. They have a few
Thousand paTienTs, plenTy of laboraTory space and a clinical

direcTor
school.

is anxious To accommodaTe research as well as The
have discussed wiTh him The possibiliTy of having

who
i

Two members

of our sTaff appoinTed as clinical invesTigaTors.

believe ThaT These poslTlons can be funded by The VA, and
bring wiTh Them supporTing funds for research, as well as a
research sTaTus which would be mosT producTive for you and Mickey
To conTlnue your sTudles excepT for The obvious handicap of
i

having a small percenTage of female peTienTs.
has much To commend lT for your work.
i

VA

am

enclosing copies of

The

The

VA

populaTion

applicaTlon ouTline for

The

posiTlon as well as a blank i0~2850.

for your reTurn

York I Think you
should apply for This posiTion by compieTinq The form and sending
me a one page sTeTemenT of your fuTure plans and ambiTions and
a proposed research plan (6.09~b~6,7).
3A5

one underpinning

To New

pun-r

�Eyre—merrnw

s,

.

i.

.,

www-

.

WF“ “sun-7w

...._...

,

-~

'--10'

vw~_m_v—.w——

I

Dr. R. Levine

June 9, I970

~2—

in +he evenl Thaf we are successful, your appoinfmenf fo
fhe Deparfmenf of Psychiafry will be ihe principal appoinfmenf.

This appoinfmeni will nof preclude your parficipafion ln sfudles
a? olher
i

affillafed insfliufions.

i would like To recommend lwo of you for These posifions and
have asked Dick and Mickey To fill ouf similar applicaflons if

They wish.
My

besi regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kp+
673C.

urn-«w «w»

�</text>
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June 9, l970

Polar

Mr.

Hammond

Execufive Dlrocfor
Nalional Coordinating Councll
Suite 2i2
l2ii Connecflcuf Ave., N.
Washingfon, D.C. 20030
Dear Mr. Hammond:

in

PR

Enclosed is a shorl biographical skeich for your use
for +ho Nafionai Coordinating Council meeflng in July.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlairy
Mszp
60C.

�</text>
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                    <text>June 9, 1970
Dr. Ivan Bennett

Eli Lilly Research Laboratories
Indianapolis, Indiana 46206
Dear Ivan,

Enclosed is a copy of a letter from the FDA requesting
since I have
information as to the formulation of methadone, studies
in
just filed an IND to permit us to continue our
opiate dependence.

written authorization to refer to the
manufacturer's formulation date for methadone as requested
in their letter.
May

I request a

Many

thanks.
Sincerely yours,
Fink, Md).
Professor of Psychiatry

Max

-

MF:kt

enc .

�</text>
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                  <elementText elementTextId="103313">
                    <text>-“,..__..,,Y.-

WV»-

,

...‘

._m...

‘,,_.......V.

WWW“?

W. mpwqup F.“

,,

“a...” .

"Hm-,MJ ..

H...rn.,.._.,...-v_...m

nu...-

,

r»

‘.-—w~ie~,-.mv

x- ...~~

-

v-

A

7w."

m.

V.”

June 9, 1970

(.7

1—.

.

"If-wl‘tﬂ)’

Qw'w-U-vmrvw

)r

Dr. ﬂerle L. Gibson, Director
Division of Neuropharmecologicnl Drugs

Office of New Drugs
Bureau of Drugs
Food and Drug Administration
Rockville, Maryland 20852
Dear Merle,

RE:

IND 6825
Methadone

With reference to your letter of May 14, 1970, enclosed
the
additional information requested, i.e., my curriculum
is
vitae and the present protocols. I have requested a letter
from Eli Lilly regarding reference to their submissions for
formulation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kp

enc .

.

v“.

—.

v.

»

�</text>
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                    <text>l
wwww-rm

mmr—w—vv—

-

Eww'wlav‘m"

w-"qur'nylvyﬂw'nlewvrvrtvn'mwttAwww—wa'

Juno 9, l970
Dr. John I. Nurnberger
Deparfmeni of Psychiatry

lndiana Universify Medical Confer
liOO w. Michigan Sf.
indianapolis 7, lndiana

&gt;wr1r

Dear John,

r-«mw»

—"r

-m

W...

"yr-WWW

,

if

was kind of you to recommend Dr. Fred Johnson +0 us.
spoke +0 you in San Francisco if was in response +0
fho question of frainees from overseas. We have posifions
open for clinical psychiafrisfs and research Trainees in
neurophysiology and biological psychiafry.

When

i

rum-I‘llw-ﬁ‘v

i
_

regrof fhaf

bu? ihank you

we do no? have a position for
for your recommendation.

Dr. Johnson,

Sincerely yours,
mum-&lt;4

Max

Fink,

M.D.

Profossor of Psychiafry
MF : k'i‘

�</text>
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wu'ar'w-nmw.

ynvm :l-g-«Q‘Tiiw-w'i‘p‘i‘

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.mvw.

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A

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A.“

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June
Mr.

Jared

R.

Coordinator

14

, 1970

Tinklenberg

Psychiatric Residency Program
mpartmnt of Psychiatry
Stanford University Medical Center
Stanford, California 9u305
Dear Mr. Tirﬂ&lt;lenberg:
and even
I very mch enjoyed our impromptu discussion
The
problem of
most
which
interesting.
are
more , the reprints
our
to
related
is
possibly
drug altered inmediate mum

studies of

menm‘y changes

in

ECI‘ ,

and the

data was even

more

interesting to us in this regard.
Thank you for the kindness in sending these reports and
in
my best wishes that the studies continue as successfully
the future .

Sincerely yours ,
Fink, M.D.
Professor of Psychiatry
Max

Mfzkp
,

1

3

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                    <text>N

mm,(

v
anvnv _,;rv,

., mun—.3...

w—

W-

nw w:.- it r~ “— n.

7

.1”

.— wrru
.

«v.

W —n-.Wm”I“., --v. 1.: M
.\

w

-

.7,

W

‘n

June
Dr.

Everett

H.

-r' ns'v'
‘

’4

v

W" r7
»

1....
. vane Wm:-a'pw.w(—»VVINuna- M1." «‘1va mum-u» in? :' 7W!“ {-1. :~»rc;z-.:-vzv
_,

,

-

, 1970

Ellinwood, Jr.

Department of Psychiatry
Duke University Medical Center
Dlmham, North Carolina 27706
Dear Everett:

I found the session on antagonists so exhausting that
I was unable to attend your session. I am sure you will mange
for its publication, and I look forward to this (albeit second

best)
v

:11”:

was

of attending.

131m again for the invitation, and I look forward to
seeing you in Prague.

,.

Sincerely yours ,

r)

1,...”

rug“...

pﬁ-

.

_&lt;

“n”,

:
.

Max

V

.
".7.

Am

-p

we

”Www—r-n—mm

W’k

nr-IW'

um

,

Fink , M.D.

Professor of Psychiatry

’3‘...“

mf:kp

�</text>
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”my

”—1.4.

.-.&lt;

{.‘A

-.

rug-’1'"

June 9, i970
Dr. Fred H. Johnson
l58 N. Humphrey Ave.
Oak Park, Illinois 60302
Dear Dr. Johnson:

regref
curriculum vlfee.
neuroanafomy.
in
or
neurology
do nof have a posiflon open

IT was kind of you +0 send your

The? we

When

was

in

I

discussed

for psychiefrisfs

I

opportunify wlfh Dr. Nurnberger, if
in Training who were parficularly inferesfed

The

clinical psychiafry or oplafe dependence.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychia+ry
Mszf

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715')

«I'RI-Z

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wan-“W:

June 9, i970

'u-wuv‘wr

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WWI-759'

.

.

Dr. John I. Nurnberger
Deparfmenf of Psychiafry
lndiana University Medical Cenfer
iiOD W. Michigan 3?.

Indianapolis 7, indiana

Dear John,

if

was kind of you To recommend Dr. Fred Johnson +0 us.
spoke +0 you in San Francisco if was in response +0
fhe quesfion of Trainees from overseas. We have posifions
open for clinical psychiafrlsfs and research fralnees in
neurophysiology and biological psychiafry.

When

i

i
regref fhal we do nof have a posifion for Dr. Johnson,
buf Thank you for your recommendafion.

Sincerely yours,

A

,

‘Iv-‘rv'vr

Max

Fink,

M.D.

Professor of Psychiafry
MF:k+
.

,

«Irv.

7Iﬂ5i1‘ﬂ'alll‘w‘V

yam-V

�</text>
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                    <text>.-v.w.r~~—.~..m.

xv-

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V0.

nM. v:“Hm,” w. .., uv“ u

.

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_,

v

V

,

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v.1

pa:
.n... vv-gzv—uu'h'vx-vww'
_

..

.w-w—w-q-waw-s-u

'niW-z-I».v
‘E'w,r'-.-n“~"NM‘KNV‘TJJW'S'W'

June 9, l970
Mr.

Polar

Hammond

Execuflve Director
Naflonal Coordinafing Council

Sulfa 2l2

i2il Connecflcuf Ave.,

Washingfon, D.C. 20030

N.

Dear Mr. Hammond:

in

Enclosed is a shorl biographical skefch for your use
for the Naflonai Coordinailng Council meefing in July.

PR

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychlalry
MF:kp

one o

.u

,-

.‘r:«-‘4

u...

-ur V,,_‘,.....‘

m-

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�</text>
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                    <text>June l5, l970
Dr. Henry Brill

Pilgrim Stale Hospital

w. Brenlwood, New York

Deer Henry,
We missed you a? The meeling on
enfegonlsfs. The dafa was
encouraging, and Three issues were feel of furfher sfudy:
l) A collaborative, mulfi*hosplfai evaluaflon
of cyciazoclne (add, if supplies are available,
of naloxone).

2)

Developmenf of long~acfing

anfagonltf, with

durafion measured in months.

'9'“

’l

3)

17w»

'I-r‘

Duran“!

Preclinical pharmacology of new antagonists
now available a? Endo, Reckiff &amp; Colman
(represenfed by Lederle in U.S.), and 3+ fhe

University of Rochester.
.q'u't'!"‘1".r“f"

A

"an:

u

summary

Science.
gamma-ma.

is enclosed, as

i

senf if to Philip Abelson of

:'-‘Vw,

Your encouragemen? has been most supporflve, and

may

”will conflnue.
My

«Wuv-Wwwawnrv'v;

beef regards.

Sincerely yours,

.7»;

‘..mwf§33IZ-‘9'F‘P§§

Fink, M.D.
Professor of Psychiefry

Max
FW‘x-ir'l’h’

wr

wars

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nm‘nrxmr

M‘srm'ﬂm‘rewm

Inhk‘i’

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frusf

you

�</text>
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                    <text>.,.._....—11.,.‘

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l

,

‘

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w,

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mwvy‘m

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June l5, i970

Irv-""31-

"zrmw

«we—v.7."

~

7......

Dr. Richard Philiipson
Hafionai lns+i+u+e of Menfal Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 200l5
Dear Dr.

wmmoruVNow—n-

Phlllipson:

Both Dr. Al Freedman and

i

regreffed your prior commiffmenfs
on oplafe anfagonisfs.

that precluded your offending fhe meeting

have been encouraged by lhe lafes? ediforlai by Philip Abelson
in Science to summarize fhe proceedings and submi? These To his
Journal for publicafion. A copy is enclosed for your informafion.

We

“w

Perhaps

we may

meal soon

to review fhis dafa.
Sincerely yours,

rwmeW-m

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Max

7..

Fink, M.D.

Professor of Psychlafry

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                    <text>E

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June l5, i970
Dr. Wilma Harrison

Geigy Pharmaceuticals
Ardsiey, New York
Dear Wilma,

Following our discussion of June i0, i am pleased to include
reports of our studies of GP 4l299. The clinical report,
dated June i, l970 (iV: 6-l0-70) summarizes the data to May l, I970
with supplements to June i. As we discussed, these clinical trials
will continue to the limit of the available supply of GP 4l299.
You indicated that IOOO additional capsules will be shipped, and we
two interim

estimate this to be sufficient to add

3

additional subjects.

will complete these trials during the next 8-l0 weeks and
submit, in September, a final report with the case records, Gelgy
report forms and laboratory summaries.
We

report (ll: 6-i5-70) describing
4i299. it is clear that the EEG profile,
at single 75 mg doses, ls readily distinguished from placebo and most
resembles the drug, doxepin. For a definitive bio-classification
study, i would recommend an oral EEG comparison against doxepln,
chlordlazepoxide, imlpramine and placebo.
am

i

the

EEG

also enclosing

classification of

an interim
GP

clinical trials in progress, we would also suggest
clinical trial of GP 4l299. i am pleased with the
present pilot data which indicates that 225~300 mg/day is well
tolerated, clinically effective and safe in our laboratory tests; and
that the target symptom is overt anxiety. From the EEG profile, i
would suggest that measures of depressive mood be added and patients
with manifest depression be included in the trial. A protocol for such
a clinical study will be prepared in September.
Based on the
a more definitive

i

trust these data are useful,

Your comments on

grateful for your cOOperation.'
these interim reports will be welcome.
and

i

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkf

enc.

interim reports

#2
#3

(iv: 6-i0~70iand

(ii:

6~l5-70)

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