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                    <text>November 5, 1970

Dear Mickey,
The

Enclosed is another piece of fan mail for your answer.
other reprint requests have been answered by Kathy.

Work here is going very well. Dick's ECT project
has completed its ftrst round of studies and the reports are good.
For the next phase we have moved the study to Metropolitan Hospital
and Dick has assumed responsibility for all ECT in the Department.
We are also working on an NIMH Sponsored
meeting that will star these

studies.

Jovan returned to Missouri. I was sorry to see him go,
but his reasons were personal and seemingly unrelated to our work.
Dick has taken over the unit, and it will continue except for the

children's project.

is now ours and the laboratories and the
studies are running well. Stanley and Rhea are enmeshed in their
studies of cannabis and heroin, and Voita is doing the EEG studies.
The computer

EEG

Recently

we

were approached by Sarnoff Mednick to

collaborate in his long term studies of schizophrenia in Denmark. I
had spoken to his co-worker, Fini Shulsinger in the late spring, and
I hope that we can launch a joint project. The population and the
studies should have particular interest for you. Indeed, Voita tells
me that in-a review of some of the data already available, he found at
least 3 boys born to schizophrenic mothers who were rated as psychotic
suring their pregnancy. These should be reviewed.

Our relations with Kirby are still in negotiation. The
at 99 Steeet should be completed by June, or so Al Freedman says.
contracts in Greece and form the narcotic antagonists are approved.

MHMHC

Our

There

is so

much going on and

I sometimes wonder

how

it

gets done- but

Dick asked if we had a position for you. Yes. Let me know
3-4 months before you wish to come and we can work out the details.
Keep up
My

the

letter writing (to the journals, that is.)

best regards.

it

does.

�</text>
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                    <text>i!”

won.

waxwrvvm-u-wa-w»—rmw-y—m:mxmmvmmwAWN:

.

'

V
.

'

'

r

,

rmwvww-w

'

.

..

,

«mm.

,

"\mw‘WN-«hﬂvar'N-o-HIW

November 5, 1970

Dr. Jonathan 0? Cole

Boston State H08pita1
Boston, Massachusetts

Dear Jon,

Just a letter of appreciation for your efforts on behalf
Americans in achieving a better drug abuse control law. I have
read the Congressional Record and the final bill, and believe that
the differences from the January bill are significant—— much of
it due to the efforts of the Committee I presume.

of

all

I trust that the Committee will not disband
skirmish seems to have been won, but will continue.
Many

now

thanks.
Sincerely yours,
Max

Fink,

M.D.

that a

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                    <text>1,
5

November 5, 1970

Senator Harold Hughes

U.S. Senate

Washington, D.C.
Dear Senator Hughes,

Just a letter of congratulations on your efforts on behalf
of more effective drug abuse laws. Your efforts in reviewing the initial
bill hastily passed by the Senate, and the final bill, represent a
more rational approach to drug control. I hOpe that your suggested
center will indeed come to pass, as it will do much to improve the
quality of the research in addictions.

efforts at developing a successful long—acting antagonist
are proceeding, albeit slowly, and with some optimism. There is still
too little leadership in Bethesda, but we will succeed.
Our

Again, congratulations on a job well done

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

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                    <text>van—m

w

7,,

vnyw—m

,,,,.

fJ-‘m'

November 5, 1970

Congressman Paul Rogers
House of Representatives
Washington, D.C.
Dear Congressman Rogers,

I

am

myself for your

writing to express the gratitude of

my

associates

and

efforts in re-writing the drug abuse control laws. In
holding the hearings, you gave many scientists and concerned citizens
opportunity to present their views to the Congress. I believe the
final bill is better than the original versions (though far from the
best) and we are grateful for your efforts in achieving this measure
of improvement.

that
bill for

hope

when Senator Hughes has an

opportunity to
again present a
an institute devoted to drug abuse control-the present leadership in Chevy Chase being so inadequate—- that you
will lead your associates in a fair review of that bill.
We

Again, our thanks.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.

an

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                    <text>November 5, 1970

Honorable Jacob Javits

U.S. Senate

Washington, D.C.
Dear Senator

Javits,

The 1970 Comprehensive Drug Abuse Prevention and Control
Act contains the provision for the establishment of a commission on
Marijuana and Drug Abuse. The efforts of such a Commission may have
a significant effect on future drug abuse laws and community attitudes.
While
is always foolish to volunteer, I am taking the liberty of
enclosing the curriculum vitae of Dr. Alfred M. Freedman, chairman
of this Department of Psychiatry and the mainspring of our studies
of opiates, opiate antagonists and marijuana; as well as my own,
If there is an orderly process in which such recommendations are made,
and if you and your staff deem it useful, I would be pleased to have
you recommend either for service on or with this Commission.

it

Many

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

mf/

�</text>
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                  <elementText elementTextId="106034">
                    <text>November

6,

1970

Israel Kesselbrenner

Dr.

Hanhattsn State Hospital

Island

Wards
New

York,

New

York 10035

Dear Dr. Kesselbrenner:
We are submitting the enclosed protocol: "Multiple Monitored
Electroconvulsive Therapy" to the research committee at Kirby
State Hospital for approval. We wish to develop a more rapid and
safe method of administering electroconvulsive therapy with

minimal memory-loss.

the

The

subjects will be those appropriately referred for

staff of

Kirby Hospital.

EC?

by

This protocol (in a prior draft) has previously been approved
the Research Committee of New York Medical College and by the
Commissioner of Hospitals for Metropolitan Hospital.

by

The work will be undertaken by personnel assigned to Kirby
Hospital from the Division of Biological Psychiatry of the New York
Medical College, and will not require direct costs by the State.

us

will need

2

rooms, one

for

an

EEG

libsratory

and one

for

an

interview room; and any modifications will be subject to your
approval and at our cost. We plan to use the available ECT treatment
facilities at Kirby without significant change.
We

are prepared to begin

Thank you

on November 15 1970.

for your cooperation.
Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

HF:kt

�</text>
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              <elementText elementTextId="45823">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                <elementTextContainer>
                  <elementText elementTextId="106033">
                    <text>-.:

.

"WV:

wawurm

Ma!

r- 1W &gt;c‘

u.

_

w," swung.” ‘m.,.,,&gt;£__.,.,_,.,,...,u_..V“_F:ﬂ.

,_

we,

&gt;

.-

M.

~q-. 7..

»_

.wwmwm..wv_s,rm-h

,.

~..

.)"-u~--

«v.,:

wxe- vIILW'ﬂ‘.-vv~,lv-.-"" 1‘1.-&lt;-‘r"'rH-rra-.mw-..v,mn.v-

«any

-.....

7..-»...w

._...._

,,.__,_

November

"‘5'

.rr

6, 1970

Dr. David Lehr, Chairman
Research Committee
New York Medical College
New York, New York
Dear David,
The study "Anticholinergic Drugs, Convulsive Therapy and
Man" was approved September 23,
1968, and initial work was performed by Dr. Robert Levine. The

Alterations in Brain Function in

attached protocol "Multiple Monitored Electroconvulsive Therapy"
is submitted as an amendment of that project. The essential
differences from the previous protocol are:

mmmvwW-n

May

1.

Administration of electroconvulsive therapy
multiple treatments each session.

2.

Addition of newer

3.

Addition of behavioral ratings (Hamilton
Rating Scale for Depression, Beckomberga
Rating Scale for Schizophrenia)

4.

puncture for assessment of
biochemical changes after ECT.

5.

Deletion of syntactic analyses, administration
of anticholinergic compounds.

memory

Lumbar

tasks.

CNS

I request this continuation be filed as an

that project?

Thank you.

amendment

Sincerely yours,

A
V

Fink, M.D.
Professor of Psychiatry

Max

MF:kt

of

�</text>
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                    <text>"r

~

‘

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'1

November 12, 1970

Yi‘v'mruwr',

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.‘Etoow

,.

Dr. Lothar Kalinowsky
115 East 82nd Street
New York, New York

wraneruw—

Dear Lothar:

Vw-_—ﬂ\'~"l‘~!"’

“£1.11

WWI-ayw-W

,mr

mtg-V

-

For two years we have been guests at Gracie Square Hospital,
and with your cooperation, have accomplished the mission originally
set - to compare unilateral and bilateral ECT. Our studies have
been gratefying. Four reports are completed, and two are in press.

am enclosing a preprint of the summary report as submitted to
the Archives, in part to thank you for your cooperation and indulgence.
Without the help and tolerance of the staff we would not have been
able to succeed.

I

Because the next phases of the study require special control
we are moving the study to Metropolitan and Kirby

of the cases,

(Manhattan State) Hospitals.

Again, my associates, Drs. Abrams, Dornbush, Feldstein, Roubicek
and Volavka, and our assistants, express our gratitude for your assistance.

Sincerely yours,

vies-wr-

an

Max

Fink, M.D.

Professor of Psychiatry

Hszt

we

wmv

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ran.

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“v.

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7

4'

If,”

P.S. You know how we valued your support and cooperation, for
without them, the study could not have succeeded. Many thanks.

.,

”.7

,e

,V

.

.

.

�</text>
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                    <text>November 12, 1970

Dr.

J.

Willis

H.

York Clinic

Guy's Hospital

London SE 1, England
Dear Dr.

Willis:

At Dr. Freedman's suggestion I am writing to re—open the
negotiations which you held with him regarding an appointment
in our programs on opiate dependence. Our studies have been
extended to encompass marijuana as well as the antagonists,

£~alpha~acetylmethadol.

If the opportunity to

to you

may

work

in this Department is of interest

I ask that you write to

me.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>A

V

”wwwnr.

I-Icvuu-n

,wv

A

mar—w

wt,

November 12, 1970

w

Dr. Charles Shegaas

Eastern Pennsylvania Psychiatric Institute
Philadelphia, Pennsylvania 19129
Dear Charlie,
Would you

letter to

please

make up a form

each member of the

candidates for membership?

APPA

so

that I can send with a
that they can nominate

Thank you.

I

a

Sincerely yours,
Fink,
Secretary

Max

Mszt

M.D.

�</text>
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                    <text>-

, 'ﬁu’i‘v

.«

-vvszr—

.

7m. -1vwwm-"‘

~x~

.

4-3-47. ,»

.n

~"n'.‘.w,'_

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7,”...

Novenber 12, 1970
Dr. G.

Harjsrrison

Associate Professor
University of Saskatchewan
Department of Psychiatry
Saskatoon, Canada

Dear Gordon,

I

am

pleased to enclose a draft copy of our

first report

changes, new in press; report on memory changes, also
in press; and a more elaborate summary, as submitted. The path
of current apparently influences the degree of EEG changes,
and the seizure also results in EEG changes (as after flurothyl)
and the separation of these effects interest us now.

on

2r

.
my

We are also interested in Inglis'suggestion of bifrontal
electrode placement yielding (in theory) less memory (and EEG?)
changes and have collected a few cases done this way.
—

.wwmw.‘

war

4
—n'

iww-W

EEG

EEG

Can

Another important issue is the possibility of left temporal
accentuation after ECT with hitemporal electrode placement.
you confirm this observation?

.

My

Inn-y

best regards.

w

Sincerely yours,

01er

r,-.

v-

wwwmwkuarma

Fink, M.D.
Professor of Psychiatry

Max
,:

my

”‘Vw.1~|-':v'zn

new

*

-,er«nv.wnr-'=$::

Mrzkt

-

&lt;

v-r"

' “*W“

�</text>
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                    <text>November 12, 1970

Dr. William Karliner

Franklin Road
Scarsdale, New York

20

Dear

Bill,
For more than two years

we

have been gueats

at Gracie Square,

and with your splendid cooperation, have completed the mission set
for us — to compare unilateral and bilateral ECT. Your special
tolerance and cooperation has made this study possible, and I am
deeply indebted. Four reports are completed - two are in press
and our overall report, as submitted to the Archives, is enclosed.
Because the next phases of the study require special control
of the cases, we are moving the study to Metropolitan and Kirby
(Manhattan State) Hospitals.

Dick, Rhea and

thanks.

My

my

other associates join

me

in expressing our

best regards.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>November 12, 1970

Dr. William Triebel
353

New

East 19th Street

York,

Dear Dr.

New

York

Triebel:

For two years we have been guests at Gracie Square Hospital,
and with your cooperation, have accomplished the mission originally
set - to compare unilateral and bilateral ECT. Our studies have
been gratefying. Four reports are completed, and two are in press.

I

am enclosing a preprint of the summary report as submitted to
the Archives, in part to thank you for your cooperation and indulgence.
Without the help and tolerance of the staff we would not have been
able to succeed.

Because the next phases of the study require special control
we are moving the study to Metropolitan and Kirby

of the cases,

(Manhattan State) Hospitals.
Again,

my

associates, Drs.

and Volavka, and our

Abrams, Dornbush,

Feldstein,

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
MFtkt

P.S. I

am

Roubicek

assistants, express our gratitude for your assistance.

specially indebted to your support.

many

thanks.

�</text>
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                    <text>“Any—n,”

November 12, 1970

Mrs. Rose T. Goodaon

Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Mrs. Goodson:

I am embarrassed to bring to your attention an arithmetic
error in my requeet for changes in categories of grant
MH—13358-0d. A copy of your signed authorization is enclosed.
If we add the changes there is a $1,000 error (plus $8800 minus $7800).

To rectify this error I would suggest decreasing the personnel
category from $123,695 to $122,695 and the approved changed amount
from minus $4500 to minus $5500 leaving all other categories the

same.

Thank you.

m...

Sincerely yours,

mun—7r”...

*w.

v”,

,

Pink, M.D.
Professor of Psychiatry

Hex

Mszt

�</text>
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                    <text>v

-

x

m- ;"3\ v.

v" w»—

--7-m-&gt;

'u"-“'

wwm

V-“J'\wa:.n:"“-”‘:Wﬁ

,V

a.“

,i

‘

.1; (uwwiiln-MIW,mvv‘” www m-«umu

rul‘w‘w

November 12, 1970

Dr.

J.

York

H. Willis
Clinic

Guy's Hospital

London SE 1, England
Door Dr.

Willis:

At Dr. Freedman's suggestion I am writing to re—open the
negotiations which you held with him regarding an appointment
in our programs on opiate dependence. Our studies have been
extended to encompass marijuana as well as the antagonists,

L~a1pha~acety1mathadol.

If the opportunity to

to you

may

I ask that

you

work in this Department is of interest
write to me.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1mm t. .r ya.

- .

1n'vumt'

-

- .

,-

,

�</text>
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                    <text>c“

&gt;=W1"\W“DX.\YV

-._-.V_._..,u.~;—v.,.

m... ...,. 7-“

,

1/ra”... _M u, a........,:w-wyn: .—
a

he?

m.V‘!-'-c“:v.‘rw—

November 12, 1970
Miss Bernice Scott
New York State Narcotic Addiction
Control Commission
1855 Broadway
New York, ﬂew York 10023
Dear Miss

Scott:

pleased to enclose our report "Treatment of Heroin
Dependence with Opiate Antagonists" which appeared in Current
Psychiatric Therapies.

I

am

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc. (5)

�</text>
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              <elementText elementTextId="45723">
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                <elementTextContainer>
                  <elementText elementTextId="106025">
                    <text>"Mm-"-

nx—an

mm mu“..-

.

_I.

7.

,

_

,

r.

,

.l

.

“www.mw, we“. ”aur.:g2;qusm;

W"..-"

uv'

U,

~

rap-mum‘-

November 12. 1970

mnmv-w—Vm

mem

7

Dr. Allen Rankin
Research Psychologist
Psychopharmacology Research Branch
National Institute of Mental Health
5454 Wisconsin Avenue
Chevy Chase, Maryland 20015

Ya

qr

.FWy—v—

Dear Allen,

for the opportunity to read your report on
depression subtypes. Taken together with Jonathan's heroic
effort to be optimistic about the variety of new studies,
your study indicates clearly that the present antidepressant
drugs are an unsatisfactory answer to depressive illness.
In part, this was presaged when, in reviewing the neuro-~
physiology of different psychoactive drug groups for the
ACNP in 1968, I found four drug classes with four different
neurophysiology patterns a reflection that no one treatment
Thank you

“var

.,

_...,.._..._,~.

,1...

_

A

_—..

—

.-..-H.—rv,w-v—u—

was

satisfactory.

.

Vx-wn'rnwv~

.w

.4
..

.0.

a

,ivﬂ-

warm-”v...“

”Wm

The reawakened

interest in

1966-67

in unilateral electrode

in multiple treatments in convulsive therapy led me
to reopen my studies of ECT, and we have made some interesting
observations. It is possible to effectively treat depressive
or
patients (of any age) within 3-5 days, without measurable
made
by
possible
is
Such
treatment
rapid
clinical memory loss.
seizure
of
and
rate
oxygenation
placement,
changes in electrode
induction.
that ECT is the primary treatment for a
It is apparent
and
that drug treatments may be most useful
depressive state,
regimens.
and
maintenance
as adjuvants

placement and

- ECT comparisons are probably useful in
the combinations
delineating the relative dosages of each, andThis
"radical" view
Imipramine

most

suitable for each depression subtype.
the initial startle reaction
it, despite
needing answers are two:
questions
specific

has much to commend
may excite. The

it

.w.-m,1.._...

WNVWW w'o. maln&gt;wwmm

�w.

-lwwww-

ww

“V.

W,”

._....A.,.

.

,~(v,'q

ww

_&lt;,..

,._—._

.t.

,W...‘,_

m

‘.,

“a “j ..

Dr. Raskin

November 12, 1970

-2—

(1)

For each of the

psychotic, schizophrenia), is

3

ECT

depressive subtypes, (neurotic,
equally useful?

(2) To what extent is a supplementary drug therapy
necessary for each subtype; and which ”antidepressant" drug is
most useful?
A direct comparison of EC? and imipraminc should confirm
the superiority of imipramine, as the Greenhlatt-Grosaer and
Shepherd~NRC studies showed. (There are 5 other studies quoted
by Klein and Davis showing ECT equal or better than imipramine.)
Perhaps, the typology and predictor approach is more useful new.

We

‘wwv—mr-wnu

-

y”

Mandela

have tried to confirm the Carney, the Robson and the
predictor scores in our recent ECT study and were

unsuccessful.

is our latest report as sent to the Archives. I
of the active ECT workers, and I look forward to discussing
this work with you in Puerto Rico.
Enclosed

know many

.-—

Again, thanks for the preprint.

.m.

wry».

Sincerely yours,
‘Wv-Fm-Mn

Max

.wrw-v

«ow—pp

mr’

-

:WﬂvT'WTW’WJrV-‘WW_Z~UWMM~

r-u

Fink gen.

Professor of Psychiatry

r,"

‘(F :kt
811C 0

�</text>
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                    <text>-—-u-

v

a"

saw

----~ '-wo‘..rVw.YW¢7:
&gt;

"my.

v,‘

November 12, 1970

Mrs. Marilyn L. Tinsley

Stanford University medical Center
Stanford, California 94305

Dear Mrs. Tingley:

have re~drafted the

NRIE reports as the rules require,
with the suggestion that one be reported when~
ever the rules allowal The report by Drs. Dornbuah and Freedman
is from my laboratory and should be included with my franchise.
we

and submit

Many

all,

thanks.
Sincerely yours,
Fink, Md).
Professor of Psychiatry
Max

MF:kt

enc .

_

‘—.--|, “m

_,__

N

�</text>
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                    <text>5“wath ,w—.-rr -n.

-.—.

mvm~v~r

mum-u-

'

-

v:

.

.

'

“V"' '-W

‘

.

,

,—_mr~

W.1—,mwwww .vr~.

.

Novnnbar 12. 1970

w—x

Wwww'w‘nv-naa-

;

E

Dr. Daniel P. Bobon

Cliniquo Psychiatriqne
Univnrsity of Liege
Rue SaintvLautent, 58
Liege. Belgian
Dear Dr. Bobon:
Dr. 1:11 has raised a quastion uith regard to our uumaary
in "The Reurolcpttcl", and an I concur with his opinion. tn
writing to ask that..1f reissued, the text be corrected.
q

On

page 14, the sentence,

"It is possible..." omits the

unjor class of thn ncuroleptics (Intipsychotics) and includes
the analgesic:. The untlgcsics havo not been adequately tested
to form a class ~ but the Intipsychotics form our largest class.
are to be congratulated on presenting n fine volume,
a acnnnto of a was: intereuting convucation.
You
My

has: regards.
Stnccrely yours.
Max

Fink, M.D.

Professor of Psychiatry

Hrzkt

cc: Turan

Ma‘w‘aw'

4‘s

Vr’uif‘v

M.

1:11,

M.D.

�</text>
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                    <text>November 12, 1970
Mr. Howard Lane
81 Central Park Road

Plainview,

New

York 11803

Dear Mt. Lane:

I

am

I have read your letter with interest,
unable to assist you.

I do not know of a
short of transfusions.

nor

way
We

and

regret that

of increasing red cell cholinesterase,
effects of choline

have not studied the

L—Dopa.

seem of interest and if these are sufficiently
section
advanced, perhaps you have contucted the clinical chemistry
Your

of

studies

NINE.

Good luck!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>i
E

g

F

E

'-

w—uv'

mmwvz—uwm

November 13, 1970

Dr. Sidney Nerlis
Research Division

Central Islip State Hospital
Central Ialip, ﬂew York 11722

Dear Sid,

I have read the volume, "Non-Scientific Constraints in
Medical Research" with much interest. It is a fine volume,
and serves a need which (I will admit) I did not see until
you brought it to my attention.

m.

in
v
wu—v-

I

You

are also to be congratulated on the rapidity of publication
report published so well, so rapidly.

have never had a

I look forward to the success of the

rsur—nw-nrvn-

volume.

Sincerely yours,
~4mvmmmm-

Fink, M.D.
Professor of Psychiatry

Max
"VII"IN"'v-r'mr.

V'I'cml-

i‘mrm'nr

~“ﬂﬂ(‘~5wwﬂ“s.“r7"rr:

o.

nvuw'mlwc-

mm»

I'W'IWF'W'V".

&lt;

a

mew-Mm-

{W

MF:kt

-

�</text>
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                    <text>w. r."

,

‘m ;u~.-.

,

November 16, 1970

Dr. Lester S. King
American medical Association
535 North Dearborn

Chicago.

Illinois

Street

60610

Dear Dr. King:
Thank you for your consideration of our brief report
on naloxone treatment. We are enclosing an 80 word synopsis

for this article.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry'

Max

MF:kt

,
.

F.’

T'm'v'r/E'uj?‘

�</text>
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                    <text>rum

‘T‘iw-vﬂ“

n,‘

«w

-

-

wine-1m

:‘.‘$-uu)'

y 'u; “4.x";

wmmmwsw.weuwy:+_a~‘ruw.’v¢-K'Wru-‘v&lt;'wV"”rr:u‘|.n-'T~WIW rv'vww‘

«Mm

m

I("'arlyF‘-,vv -

1

.77;

.

'."~'-".‘——

r

.,

rm,

November 19, 1970

Dr.

Fritz

A. Freyhan

St. Vincent's Hospital
Street

153 west 11th

New

York,

New

York 10011

Fritz,

Dear

correction for the ﬁinutes will
trust the record reflects our discussion.
Your

For your information, I have asked

the information regarding the Editorial

entered,

secretary to make
journal.

It is clear that

Sincerely yours,

7"“.w—u—vﬂ.

rm.p:"

Max

3.”

mm,

..,

MF:kt

w
‘-

P"»"WF'uI/D—v~

c
»

-‘uTmM'

Fink, M.D.

Secretary

&lt;

me

I

Board of the

,-

~1ﬂm'wmwmguv‘mr

and

the journal is a creature of Dr. Stratton,
that the designation of "official journal" is nominal. In
view of the other changes at Grune &amp; Stratton, it would be useful
Councillor) could review
if you (as Editor-in~Chief and an APPA APPA
and suggest to the
the relationship of the journal to the
which
would
perhaps establish
publications committee a course
the journal truly as the "official journal"?
and

Vnr'M‘I—v'

my

be

.—.~

7-.

~34."

�</text>
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'

'r'r

1“qu __.,.. w." .,_w, y........_“~-q_~,.qn
V

Nut-"‘1“ .n-a

WWW—"m

war.

.m $-emw-wv»a.»

-w.-

“tent

wsmv&lt;

nvw— «-—=-w-n.4,.

November 20, 1970
Mr. James

J.

Mynatt

Assistant Director
Legislative Council
State of Tennessee

Committee

Nashville, Tennessee
Dear Mr. Nynatt:

Enclosed are two recent reports describing the present

findings in studies of narcotic antagonists.

The use of the antagonists is limited by their short
duration of action. The need for laboratory studies is
great, but these are funded inadequately.

of a long acting depot antagonist will
provide a logical treatment of opiate dependence, particularly of
young persons, and a prophylactic. my estimate is that, with
financial support, such a development may be available in 1972.
The development

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
enc 0

.

7.9.“

A

�</text>
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                    <text>'v-AWW

rw—ww—o.

"Wm

~u

w-W,

November 20, 1970

Dr. Edgar Grunwaldt

Geigy Pharmaceuticals
Ardsley, New York
Dear Ed,

Last

we embarked on a sequential drug evaluation study
and adolescents. Seventeen patients have been studied,

fall

in children

and a summary of our

initial

data is enclosed.

vehicle, and a summary
patients received Tofranil in liquid forms
and
are enclosed.
Geigy
the
laboratory
record
of each case
Two

study was both difficult and expensive. As Dr. Simeon
has returned to St. Louis, I have deferred further admissions to
the project.
The

I want to thank

you

for your assistance

and encouragement.

Sincerely yours,
Fink, rm).
Professor of Psychiatry

Max

nrzkt
enc o

�</text>
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                    <text>~m-r-swmm v arm-V.—n- u v ﬁvm‘x

November 23, 1970
The Honorable James H. Scheuer

House of Representatives
Washington, D.C.

Dear Congressman Scheuer:
and concern of the attendees at the Michigan
methadone
was obvious. Your question, that of
conference in
methadone
available to your constituents
assistance in making
with
my associates, and they concur
discussed
was
in the Bronx,
The

interest

in the sense of our discussion: support for the further
development of the narcotic antagonists in exchange for

methadone guidance.

on my desk,
Addiction
Narcotic
York
State
which I
which
and
optimism)
with
Commission
(although
little
Control
would be suitable for support.

I

It

have two

useful proposals for antagonists

plan to send to the
was

New

stimulating to discuss the addiction problem.
Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

nf:kt

�</text>
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                    <text>a.“ &gt;y'v"

November 23, 1970

Congressman Mario Biaggi
House of Representatives
Washington, D.C.
Dear Congressman Biaggi:

During the past few months, one of your assistants has
inquired as to our progress in developing a useful opiate
antagonist treatment for heroin addiction. On each occasion,
I indicated that there was no need for additional funds.

I now have two proposals for studies which are
in developing a long acting narcotic antagonist as a necessary
in opiate dependence, with budgets of $400,000 a year.prophylactic
At a recent educational session

Scheuer expressed an

for physicians,

Congressman
making

interest in obtaining assistance in

methadone treatment more readily available to the addicts of the
My associates and I are both willing and able to
assist
in this program, using the medical practitioners as methadone
therapists, under prevailing Federal and medical guidelines.
we suggested that such an effort focussed on an imuediate
”solution"
would be of interest chiefly if it provided a basis for the
deveIOpment of a prophylactic approach.

Bronx.

It

may be

their impact

apprOpriate to discuss these proposals, particularly

on your

constituents.

Sincerely yours,
Vita}!

Fink ’

:4. D u

Professor of Psychiatry
MF:kt

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.

.m-wwvw—awm. MW..."

.«r .»

m

a...

November 23, 1970

Dr. James MCGaugh
Department of Psychobiology

University of California at Irvine

Irvine, California

92664

Dear Jim,

tell you that I very much appreciate
candid
and
response to my inquiry. The proposal
prompt
your
for a conference on memory and ECT (ECS) has been favorably
received, and is now ”in process". As soon as I have any
Just a line to

"news",

I'll write or

Many

call.

thanks for your

interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hszt

-'-"'—'—mmwu :Vnw- p.

q

way-.2

.mw—

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                    <text>v

,- ~wwmm~zv~rvo~w

.

\\-'€-(Mw.Vaalvm'

.

-.-.- Fwy-n

mmv «sh-w" "'lr'x'

.

»

w—w-n

rnr-v

a—

wva..-..- . r.w--ew'.w-'W a... ".17...

:w

l 1..."...— ‘NW “c.

-:

i,

r-.."

November 23, 1970

Va.-

l“-‘.v1y‘~‘

——-. (-u-r.“ ”VVW—gw

Virgil A. Place
950 Page Hill Road
Palo Alto, California
Dr.

Alza Corporation

Dear

94304

Virgil,

I appreciate your interesting suggestion for the development
of a long acting antagonist. As you know, there is a public
committment to methadone, and it may be difficult to achieve the
requested level of support immediately, but I an optimistic that
the interest in antagonists will be re—awakened.

it.

1)

My

associates

have read the proposal and we

will

2) A copy has been sent to Dr. William Martin, for
and comments. Re is on the appropriate NIMH committee.

recommend

his support

will be included in our l971«72 contract renewal
York State Narcotic Addiction Control Commission, for
review on or before April 1, 1971.
3)

with the

A

summary

New

I have read the Alas annual report _ 1970 - and wish to support
your efforts in developing more physiological release forms of
psychoactive drugs. Our interest in the antagonist is part of a
broader interest in the effects of drugs altering the CNS for
prolonged periods for therapeutic ends. In 1964, fluphenazine
enanthate was the first formulation that provided a solution to
the problem of recidivism in seemingly successfully treated psychotics
patients who responded rapidly to treatment and relapsed when they
felt so well that they "forgot" to take their medication. In
numerous studies, many in our laboratories, this formulation has
been successfully applied in patients now in continuous treatment

for

3—4

years.

~

._

.3.

�aa,..mwnv-.N.Wy

—

‘

-2-

Dr. Place

There

It

may

next you

November 23, 1970

is a need for similar formulations for snt1~psychot1c,

anti~epileptic

and

anti-depressant drugs.

be useful to discuss such needs and

are in the East.

applications,

Again, my thanks for your presentation, and I
submit it for support.

am

Sincerely yours,

«-

v

amw‘vv

Max

'1rmnmmmmuumu-mm—v

a
--

'4-1-W‘r

I’l-n:w'lmwrn~iuplnv7—Y

.fF-"wv

-rnrwrvrm-.wrmn

mus-.W-mm-u—M

W"m~’3."'“

-wﬁwyr

Fink, M.D.

Professor of Psychiatry

«w:

Mszt

_.

when

pleased to

..(.,V_-.......r\

"pen-.5

�</text>
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                    <text>L7:

in:

‘41::

“1

November 20. 1970
The Honorable Melvin R.

Secretary of Defense

Laird

Washington, D.C.

Dear Secretary Laird,

Reports of increasing use of drugs and deaths from opiate
use in Viet Nam prompts me to bring to your attention the enclosed
studies of opiate antagonists. These agents provide a logical
prophylaxis of opiate dependence but do require additional

research effort.

contracts are

now

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

enc

o

eb‘mx.;::~:

its“-

,2,

in progress under New York State
would
be
useful for the Defense Department to
auspices. It
view
towards supporting, encouraging
review the data with a
or undertaking efforts in this development.
Some

.4}.

"tat-ti:

VJ.

ww-

,.

�</text>
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                    <text>Hovember 23, 1970

Dr. William Martin

National Institute of Mental Health
Narcotic Addiction Research Center
Lexington, Kentucky
Deer

Bill,

Enclosed is a xerox copy of the salient documents from
Alan Corporation, relevant to their participation in the
development of a long acting antagonist. As it is unlikely
that we, alone, could obtain such funds or encourage such a
project, we would appreciate your advice.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
811C

0

�</text>
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                    <text>November 23, 1970

Dr. Leo E. Holliater
Veterans Administration Hospital
3801 Miranda Avenue

Palo Alto, California 94304
Dear Leo,

After cending you the abstract, ”Alert EEG Classification
of
Psychoactive Drugs", I reviewed the presentation and
believe the enclosed revision and new focus is more appropriate
to the Society.
New

Bioavailability is a principal concern when drugs are
role
prepared in new formulations. If the EEG has a specific
CNS
index
of
be
useful
an
effects,
as
in drug evaluation, it may
and as a measure of equivalence of dosages or dosage forms.

If possible, the enclosed abstract should substitute for

the one sent
Many

earlier.

thanks.
Sincerely yours,
Pink, ”.0.
Professor of Psychiatry

Max

MF:kt
one o

�</text>
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                    <text>November 23, 1970

Dr. Hans Lukas Teuber

Professor of Psychology

Mossachusetts Institute of Technology
Boston, Mbssachusetts
Dear Luke,
Thank you for the two sets of interesting reprints.
After a flurry of excited activity, the suggestion for a
conference on ECT and memory is on the desk of Washington's

satisficers.

After a few more weeks, I will try to extract the
proposal from the mountain of papers above it.
my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>w.

.

m

'T‘v’rY‘VM

v-W-wmmwnmmmaw-w‘
,

,

w .w

m‘wu-wruw-KXVvvn-wv-wwxmv.l- u
-

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um

«w .;i('&lt;.v»wn'v1.

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1:- :.—

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~.:

-

November 23, 1970

Dr. Benjamin Pasamenick

Division of Mental Hygiene

80 Holland Avenue
Albany. New York

Dear Ben,
Al and I met with Alan Miller last Monday, and I believe
that a viable relationship between DHH and NUMC is likely. For
my part, I look forward to extending our clinical studies and
residency training activities to the pOpulstions at Kirby.

There are two programs which are of immediate interest.
In 1968, I renewed my interest in ECT and we have completed
a study of unilateral-bilateral ECT. Electrode placement is
significant for memory and EEG changes, but not for clinical
behavioral results, suggesting the feasibility of developing
an accelerated ECT schedule without memory impairment. It is

this possibility

we

are

now

investigating,

and would

like to

extend the study to Kirby. I am enclosing a copy of the report
and the protocol of the proposed study.
we

are also interested in continuing our studies of

hormonal factors in schizophrenia and, as one study, propose
to examine the effects of penicillamine. That proposal is
being revised and I will send you a copy when completed.

It may not be too soon to review the procedures for
experimental studies at Kirby. I have the assurances of
Al Freedman, Alan Miller and of Israel Kesselbrenner, but
an unclear as to any additional steps which may, at this
time, be necessary.
Any

suggestions?
Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Me:

MF:kt

eat

0

»

7

,

,

,

l

�</text>
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                    <text>November 26. 1970

Dr. Sidney Marlin

Central Islip State Hospital
Central Isllp, ﬂew York

Dear Sid,

I have read the list of candidates for membership in the
I believe the committee ban a difficult responsibility,
to select the most capable from among a list of eminent researchers.

ACNP

and

I would like to endorse (if that is appropriate) the nomination
of the following from the list, no scientists whose work I know
and who I believe would contribute to the work of the College:
Samuel Barbados
C. Keith Connors

Ronald S. Lipman
Donald A. Overton
Eugene Stern Paykel

Burton 3. Goldstein
Jerome K.

Joffe

Allen Raskin
Richard E. Schultoo
Andre Villenouvo

Ali Keskiner
Milton Kletzkin

Sincerely yours,
Max

Fink '

2‘1

0

D-

Profesaor of rsychiatry

MF2kt

�</text>
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                    <text>Fﬂ'wxwmw

.—

Novembar 24, i970
5

Dr. Sheidon Gayitn

Grasslands Hospifai
Vaihaiia, New York
Dear Shel,
I

am

pleased

To recommend Dr. Arthur
He compiefed

to fhe sfaff of Grasslands.

Zaks

for appoinfmenf

his residancy in our
Departmenf in I968 and has been an acfive researcher since i966.
He is one of +he nafion's principal sfudenfs of fhe opiafe
anfagonisfs; has wriffen exfensiveiy on cyciazocine, naioxone,
and heroin; and is now The director of fhe addicfion service
(Ward iE—A) a? The Mefropoiifan Hospifai Medicai Cenfer.
i

hearfiiy

recommend

his appoinfmenf.
Sinceraiy yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kT

�</text>
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                    <text>November 24, i970

Dr. Sheldon sayl'pn

Grasslands Hospital

Valhalla,

New

York

Dear Shel,
i

Abrams

pleased to recommend the appointment of
to the staff of Grasslands Hospital.

am

Dr. Richard

Dr. Abrams completed his residancy in psychiatry in our
Department in l969. He has been a scientist of the Division
of Biological Psychiatry since l968. He completed two years

military service.

Since |968 he has been the project director of our
study program. He carried out this study well, and has
written more than five fine reports.

to

He

has Just been qualified by the Boards and
his promotion.

recommend
l

heartily

recommend

l

was

his appointment.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kt

ECT

pleased

�</text>
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                    <text>November 24, l970

Dr. Sheldon Gaylln
Dlrec+or of Psychlafry

Grasslands Hospllal
Valhalla, New York l0595
Dear Shel,
am pleased To subml? my appllcallon for appolnfmenl
to fho Dlvlslon of Psychlalry 5+ Grasslands. l hesllafe lo
submlf lelfers of recommendaflon, ofher than Al Freedman's,
for any ofhers would be redundanf and BEE formg.
I

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlalry
MF2kT

�</text>
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                    <text>November 27, 1970

Dear Mr. Poterba,

I regret that my schedule of appointments made it
you in person for your thoughtfulness in making
a drug administration kit available for this laboratory. It is
a useful addition to our facilities, and I thank you for your con-

difficult to thank

sideration.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>November 29, 1970

Dear Bob,

It

and I am

has been some time since

we

have heard from Texas,

writing to bring you up~to~date with the programs here, and
to ask if your plans for 1971 are sufficiently clear to be discussed.
I have just written to Mickey, and have offered him a position in
the Division.

wuw

wmypwwr.

»

1";"0‘merélwmw‘

During the past month we have negotiated an agreement
with Albany that permits us to assume responsibility for Kirby
Hospital-- training and research- and the necessary clinical
programs. We plan to start with the MMHC units (5 &amp; 6): we will
name the unit directors, send residents from the MMHC pool, and
be responsible for teaching and treatment. The director will be
Kesselbrenner, who will be part of the NYMC faculty. We asked to
have the funds through the College but this was refused, and
we will appoint to their budgets. All appointments will be joint, and
for the two units the appointments will be to the Division of Biological
Psychiatry.

1,2,3 or

We

do

not

know whether we

will divide the

4

units into

number depending on the staff we can recruit
and the type of research programs we wish to start. ECT and penicillamine
4

sections, the

are already projected;
Would you

studies are in the planning stage.
like to join this Division this summer ?
new drug

If so, I will be pleased to

work out the details. (There are so many
other projects in the works, that the choice is a good one, now that

we

have some funds
Keep

again).

well,

and

write soon.
Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>ii

11

-m"-AW-»~N_J-

mmw

v

-

r
-.

v'm.r‘v"v'wnwmﬁ‘5rvrﬂ

November 30, 1970
'1
s

Dr. Chris

Zerafonetis,

M.D.

University of Michigan Medical Center
Department of Postgraduate Medicine

Ann

Arbor, Michigan 48104

Dear Chris,

that

I very much enjoyed the sessions in Ann Arbor, and regret
I was unable to remain the full week. I look forward to

the publication of the Proceedings.

Enclosed is a draft copy of my report, "A Rational Therapy
of Opiate Dependence: Narcotic Antagonists”, for your consideration
for the volume.
The unusual interest in methadone surprised me.
practitioners are accepting methadone maintenance as

Many

a quick

cure of the opiate addiction problem. It is a facile solution,
but one which promises much more than it can deliver. But in
our experience, it merely exaggerates the problem and delays
any definitive solution. With all their limitations, the
antagonists provide a possible "real" solution.
I trust the report will be acceptable, and that any
summaries or overviews may reflect the dilemma and its doubts

that trouble us.
Again,
meeting.

my

congratulations on the organization of a fine
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>nxrm

.

v—

‘

»

--——

rr—twwu-w-mwv.v- w, . ewpu- w. m —

November 30, 1970
Dr. William Guy

Biometric Laboratory
1145 19th St., N.W.
Washington, D.C. 20036
Dear

Bill,
Thank you

for the print-outs

and the cards of the

Hamilton data on our ketipramine study. The data is
most interesting and clear. I have a question about the
what does "p" or "g" mean for ”type”?
summary letter
In checking the new manual, (which is most useful), I
could not find these symbols.
—

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>August 3, 1970
Dr. Hermon

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Hermon,

Separately I as sending you three copies of the summary
report and the statistical data of the EEG studies of ore!

thiothixene.

s pilot phase and a preliminary
These data become the basis for the study

As you know, we undertook

profile study.

presented here.

profile of a single 10 mg dose of thiothixone is
cleerly defined, distinct from placebo, and identical for both
the capsule and concentrate formulations. The profile of
thiethixene is consistent with the sntipsychotic class of drugs
in our published classifications. (Ann. Rev. ﬁtment” 9:
The

EEG

241-258, 1969).

I went to thank you for the opportunity to undertake this
took much longer than I anticipated.
study and I regret that
much
and I am pleased with the outcome.
we
did
learn
However,
very

it

My

thanks for your coooeretion in this study.
Sincerely yours,

u
w

.&lt;.-»-

Fink, M.D.
Professor of Psychiatry

Max
"ﬂ'ml4lmﬂ'w’m”4m‘

VIM-vrmmw‘r

-

Mszt
cc: Dr. Berger

�</text>
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                    <text>August 3, 1970
Dr. Noreen

Pitts

Chas. Pfizer and Co.
Groton, Connecticut
Dear Norman,

have completed the next step in the EEG profile analysis
of CP 14,368. In a comparison of single 250 mg oral doses in
male volunteers, we did not elicit a systematic EEG pattern,
although the usual behavioral and BBQ effects of a placebo were
we

inhibited.

Failure to

or the dose of

elicit

CP

the profile may relate to the sauple site
to the possibility that at this dose,

14,368 - or

its central effects

are variable and unsystenatic.

.

mw”

-ww-wn

ww-ymw.r'.

I an not convinced that the sample site is too snail, since
elicited a well defined profile with the same subjects in
another compound, under the some conditions. If the problem is
the dose selected, then we should consider a repetition of the
study at a higher dose or a multiple dose study.

we

I would like the opportunity to meet with Al ﬁeissman and
other scientists at Pfizer with an interest in C? 14,368. This
will make it possible for no to check my experiences with theirs
and provide the basis for recommendation.
I will be away until September 1. but would like to arrange
1 meeting,
that is possible, early in September. Separately
I am sending you three copies of the data books and the summary

if

report.

Thank you for your cooperation ind
examine this interesting compound.

for the opportunity to

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc: Dr. Berger

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                    <text>E

g

E

E

E

August 3, 1970
i

”“5“

"-1-“.

W

""‘ﬁ'vmfﬂdr'd’aJ'Fu-JKWu'yy‘n-w

Dr. Jack Freund, Vice President

A. H. Robins Company
1407 Cummings hrive

Richmond, Virginia 23220
Dear Jack,

I have read the reports on sulpiride (Dogmatil) with interest.
data consists of translations from French of 17 clinical studies
and one animal assay, published 1968-1969. The principal clinical
reports of Borenstein gt_§&amp;; (Ann. Med. Paychol., 1: 90~99, 1968;
and 2; 560~74, 1968) are frequently cited but are lacking in this
The

collection.

In the continental manner, case records are cited in general
terms and it is difficult to assess the data. Four groups of patients
have been treated: schizophrenia, depressive psychosis, depressive

neurosis and neurovegitative disorders.

I found the reports of Collard (1969), Mathey gt §£;.(19693 and
Naviau (1969) best for clinical material, and that of Borenstein 33 a1.
(1969) for an animal EEG study. From these data, it is probable that:

l. sulpiride,

300-1600 mg/day,

is

an

agent, with alerting and stimulating features;

active antipsychotic

2. it may have less potential for parkinsonism or seizures
than other active antipsychotic compounds;
3.

it

has antidepressant

activity, particularly in agitated,

elderly patients (Renault. 1969); and,

4. it has some anti-vertigo activity
anxiolytic features in neurovegitative states.

and may have other

citations are difficult to interpret, since the reader is
faith in the observers (it is assumed that they are known,
or that their clinic will carry the weight of authority behind the
observations), and controlled data are not presented.
These

asked to have

�-"-~“"W«W"‘

"‘N‘”V~w- "W- \"n'

s

'

u

.

~

.

‘YW‘WV1”'WWx-r4umw"‘ﬁwa-H'll'xw'va u.1~~r)'w'-UL-rwwmuw—-V". -.wo-u~.~u-‘_..,ru

“—um-v-uwr

WM!"

n;
,1
&lt;

anvvnrurv-

"yur'""b.'z

my...“

-2-

Dr. Freund

August 3, 1970

I have known P. Borenstein since 1958. He is an able electroencephalographer and clinician. He is dour, carries a heavy burden
of studies, publishes often and has well trained European assistants.
In Liege, in Harch 1959, I heard him discuss a new, all-purpose
psychoactive compound, with well defined EEG activity. I don't
recall the name of the drug, for he told me that the compound was
not available for American studies; but I believe it must have been
sulpiride. His enthusiasm did not get a good reception, since many
in the audience were preoccupied by other new compounds, chiefly
pimozide and fluspiriline, two Janssen compounds in early clinical
trial. (The conference was in Liege with Janssen support, and many
of the participants were his investigators.)

Collard’s report is also a good one. I know the director of
his choice, Professor Bobon, as well as his son. They are enthusiastic

and probably able psychoPharmacologists, and perhaps these observations
should be treated seriously.
.

If

you seek another psychoactive compound, the data of these

studies are sufficiently supportive of a broad spectrum antipsychotic
(and antidepressant?) to warrant further study. It also has interesting
anti-vertigo properties to support its antipsychotic potency.
I would suggest Borenstein's initial reports he read and his

present views be obtained.

Also, the present views of Collard and

to visit these centers, to
discuss the clinical material in detail, and to assess comparisons
with other active compounds in the same clinics. In the case of
Borenstein, it would be interesting to review his EEG material.
Bobon and Naviau.

It

may

be useful

I am attending the CINP in Prague in midsAugust. As this is a
biennial Opportunity to discuss new compounds, I have checked the
list of titles and sulpiride appears only once. J. M. Sutter, g£_&amp;l;,

of Marseille are reading:

effects of

a new drug:

”Controlled study of the psychotropic

Sulpiride.”

for the opportunity to review this material. It
that I should take better notes at huronean clinical
meetings, and will try to do so. (I am returning the translation
separately.)
Thank you

reminded

My

me

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

cc:

Dr. Tabor

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                    <text>August 20, 1970
Mr. Robert

Petersen

Grass Instrument Co.
101 Old Colony Road

Quincy, Massachusetts
Dear Mr. Petersen:
one Grass Mechanical Timer, Model MT7A,
Serial No. 70208. We would appreciate your having it
repaired and billing me at the above address.

Enclosed

is

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>September 2, 1970
Dr. Shiroe Miura

Department of Neuropsychiatry

Tokyo Medical College Hospital

6u7-1 Nishishinjuku
Shinjuku~ku, Tokyo, Japan
Dear Dr. Miura:

It

of you to apply to work in this laboratory,
you have obtained funds independently.
As
wrote, however, we are unable to accommodate any additional
staff until our new facilities are completed in 1971 or early
and

it
I

was kind

is useful that

1972.

As

plans

I

will see Dr.
fully with

more

Kate in November, I
him at that time.

will discuss your

Sincerely yours,
Fink, ”.0.
Professor of Psyohiatry

Max

MF:kt

�</text>
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                    <text>September 2, 1970
Dr. Muaaki Kato
Chief, Addlt Mental Health
National Institute of Mental Health
l~7-3 Koonodai, Ichikawa City
Chiba—Ken, Japan

Dear Dr. Kato:

It

to seeing you in Ann Arbor in November.
will give us an Opportunity to discuss Dr. Miura's application.
I look forward

As I

wrote,

it

will not

be possible

to arrange for

an

additional

facilities
fellow in this laboratory until
The new facilities are not available to us until late in
1971 or 1972, at the earliest.

expand.

our new

give us space to

Sincerely yours ,
Max

Fink, 34.9.

Professor of Psychiatry

Mszt

�</text>
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                    <text>September 2, 1970
Dr. Arnold Friedhoff
550 First Avenue
New York, New York 10016
Dear Arnold:
amount of $10.00 from William E.
Bunney, Jr., H.D. who has accepted membership in the APPA.
Please add his heme to the membership list.

Enclosed

is a check in the

The address of Dr. Albert J. Silverman should be changed as
indicated on the attached card.

Sincerely yours,
Max

Fink, M.D,

Secretary

MF:kt

enc .

�</text>
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                    <text>September 2, 1970
Dr. John L. Schimel, Editor

Career Directions

40 Gramercy Park North
York, New York 10010

New

Dear Dr. Schimelz

Enclosod is a corrected capy of the summary "Toward A
Rational Theory of Behavior". I regret that the previous
copy which was submitted hurriedly had many errors.
I

trult this

new

draft is satisfactory.
Sincerely yours,
Max

mm,

mm.

Professor of Psychiatry

MF:kt
011C.

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«

1

,.y___1-__,w—-W

.

-w-ww~r“w“mww

n...

w'ﬂ-IF-m"

,.
.7

rqvww-u-nvvgyw-nmw-mraw

1-

September 2, 1970

‘

Queen's Printer
Ottawa, Canada

E

Dear

Sir:

would appreciate a copy of the LeDain report,
an enquiry into the non—medical uses of drugs, as recently puhlished.
Would you advise us as to the proper procedure to follow ?
We

Thank you.
WWF"EWW'SJ'PAWW'MP¢VF"W1

Sincerely yours,
Max

-ngm—n~mw

Pink, M.D.

Professor of Psychiatry

WW.

mf/

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                    <text>September 3, 1970
Dr. J. R. Wittenborn
Rutgers ~ The State University
New Brunswick, New Jersey 08901
Dear Dr. Wittenborn:

It was great fun in Istanbul, and I do think Turan did a most
admirable job in organizing such a fine meeting. I an writing about
two different thoughts, and ask your advice.
1. In Prague, I met Dr. Peter Fell, a research director of Organon
(Netherlands). Dr. Fell is a most knowledgeable psychopharnacologist and
I believe can contribute to our ACNP sessions in Decenber. I would like
to invite his attendance and ask that you send him such forms and notices
as he may need. His address is:
Dr.

Peter J. Fell

Basic

Human

N.V. Organon

Research Department

Oss, Holland

2. You will recall that l have been posted as Chairman of the ACNP
Nominating Committee. In the business meeting of the GIMP, I was impressed
by the totally undemocratic and restrictive nature of their nominating
procedures, and was stimulated to think of our own procedures. Our own
method is much better, but perhaps it can be enhanced by an invitation to

the membership to recommend nominees to the Nominati z Committee. If it
is not too late, would you accept a request for a mailing of the enclosed
note to the members; I am aware that it may be too late for this year, and
will not be disconfeted if unfeasible.
Thanks

for your coOperation.

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>l

September 3, 1970

Dr. A. Bruner

Experimental Psychology
Lovelace Foundation

5200 Gibson Blvd., 8.E.
New Mexico 87108

Albuquerque,
Dear Fred,

In my recent travels I visited the harmacology laboratories of
Organon in 055, Netherlands and net Dr. venReCzen. He has a well
equipped neurophysiology center and is specifically studying psycho~

active drugs that seen to alter
and compounds were new to me.

memory

processes.

Some

of his techniques

I described the 1970 Aspen Brain Research meetings
with such enthusiasm that he inquired as to the possibility of his
attending in 1971. I am writing to ask how this can be arranged. I
believe he can make a useful contribution, if asked.
I found

that

Dick Rech called me in June and we outlined some suggestions for
a symposium on drugs, brain function and EEG measures and I trust the
program will gel.

project? We had
great difficulty in obtaining a continued supply of naloxone, and only
recently were able to get a fire comeittnent for another year.
what progress has been made on the addiction

My

best regards

~

and

my

thanks for your cooperation.

Sincerely yours;
Max

Fink, M.D.

Professor of Psychiatry

Mszt

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Dr. G. F. Blane

Clinical Research Co-Ordinator
Benson Lane

Hull, England
Dear Dr. Blane:
we

would

studies of

your copy

like to continue our exploration of antagonists

M5050.

I have

is enclosed.

by

obtained an import permit (#2533) and

Can you make a small supply

available?

available a description of the completed animal
toxicology, and a description of the fbrmula, chemical synthesis (in
narrative outline or literature references), address of site of
preparation, and a copy of labelling data. I will need these for
the U.S, F.D.A. to file an IND.
I trust these are the next steps, and would like to proceed.
Can you make

You

will note that the permit lists

M99

be ignored.
Many

use of

thanks for your cooperation.

this interesting

compound.

as well -

this is to

I hepe we can make some

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt
611C 0

clinical

�</text>
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                    <text>September 3, 1970
Dr. Hans Hippius

Nervenklinik der Freien Universitat
Ulmenallee 30
1 Berlin 19, West Berlin
Dear Dr. Hippius:

First let

me

congratulate you

on your

election

as

President-

implied criticism of the
Elect of the
had
more
to do with the patent
actions
nominating committee's
America, particularly
from
CINP
North
of
the
rejection to Fellows
of your nomination
criticism
than
any
the United States, rather
which I endorse
nominations
both
or that of the new treasurer,
GIMP.

You

know,

that

my

heartily.

I am

As

writing because

I

am

interested in the

I discussed with you, the data suggests that

new drug,

it

may

psychoactive properties and as such I an interested in

sulpiride.

have unique

its

EEG

profiles.

I would be grateful for any preprints which you may have of
your work or that of Dr. Degkewitz, as well as any pharmacological
data which may be useful to me.

Also, I would appreciate the

may have

It

studies this

was fun

names

compound.

German CINP

My

and I hope that I will
see you sometime soon in your new laboratories

sessions

—

interest to participate

once again

the ones in Nurenherg were most stimulating.

best wishes for your success.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HFtkt

who

getting together in Istanbul

have the opportunity to
in Munich. Perhaps it would be of

in the

of any investigators

�</text>
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              </elementText>
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                  <elementText elementTextId="106000">
                    <text>September 3, 1970
Dr. P. Simon
91 bd. de l'Hopital
75

Paris 13, France

Dear Czardas,

It

was a pleasure working with you once again. While the program
was larger than we both wished, I left with the feeling that
meeting was a successful one. I know that my family enjoyed Prague

in Prague

the

very much.

You may

recall that

stand that the

subjects.

The

I discussed

my

compound has a wide range

interest in sulpiride.
of psychoactive

literature is quite confusing and

I am

I under—
effects in some

writing to ask for

any information that you may have available. I would appreciate any preprints and reports regarding studies from your lahoratories. Also can
you tell me who may have carried out clinical studies?
My

best personal regards

United States you will favor

and I hope

me

with a

that

visit.

on your

next

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

visit to the

�</text>
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                    <text>September 3, 1970
Dr. Paul Janssen
Janssen Pharmaceutics

Research Laboratory

N.V.

Boorsc , Belgium

Dear Paul,

First of all, let

of the

CINP.

have selected.
My

I can

me congratulate you on your election as Treasurer
think of no one more qualified that the College could

interest in the classification of novel

compounds by EEG

criteria

to review the printed data on sulpiride. It has been
studied extensively by P. Borenstein who has found interesting EEG changes
and for this reason the compound was brOught to my attention by an American
pharmacologist in the v.5. You may recall that I discussed this compound
with you in Prague and I am writing to request any proprints or published
data regarding the pharmacology that you may have available from your
laboratory.
has recently led

me

I would be most grateful if you might also list the
of your acquaintance who may have worked with sulpiridc.
My

personal regards to your wife.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

names

of investigators

�</text>
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                    <text>v.

.

mmsm.--mW—wwww...s-.ww.~...-.,.w

Septenber 3, 1970
Dr. Arnold

J.

Mandell

University of California,
P.

O. Box 109

San Diego

LaJolla, California 92037

owu—PWWrsw

.“ww...

Dear Arnold,
I look forward to seeing you in sunny California in February.
There are two topics under study here that would interest the Society.

l) Antggonists in Opiate Dependence: The conditioning model of
opiate depen ence suggests that ”do-conditioning“ could occur if self-

stimulations (needle + drug) went unrewarded repeatedly. Successful
treatment of opiate dependent subjects with narcotic antagonists
(cyclazocine and naloxone) provides support for this theory, and the
basis for a useful therapy in this and other addictions (as amphetamine
and alcohol) (presented with A. M. Freedman).
Convulsive Therapy:

2)

Recent modifications of convulsive therapy

(unilateral convulsions, multiple monitored seizures, inhalant induced
seizures) have focussed interest on the relation of memory change,

altered brain function (EEG) and behavioral change (improvement).
Unilateral induced seizures produce significantly less change in various
asymmetric EEG changes and equivalent behavioral changes
to bilateral induced seizures. This dissociation of therapeutic and
”side" effects allows multiple seizures to be given in one sitting -

memory

tests,

with therapeutic benefits. These observations are of interest to the
theory of convulsive therapy and to the relation of brain function and
tests of memory (both immediate short term and delayed).
I
My

trust that either topic will interest the

members.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

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                    <text>September 3, 1970
Dr. C.

J. Miras

University of Athens Sdhool of Medicine
Department of Biological Chemistry
Goudi, Athens, (609), Greece
Dear Costas,

Enclosed is a copy of the 1969
I do not have the 1970 list.

list of

NIMH

cannabis grantees.

It was a pleasure to work with you in Athens. I will approach
the contract people for an adjustment of our project and advise you as
soon as I have any information.
you for your thoughtful
courtesy and the time you spent with us.
My

girls thank

My

best regards.

gifts,

and

I, for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

enc .

your

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                    <text>w

...

we,

r
A-

“m"v—V‘V'

'1.‘w—’meK-'

1'1"

September 3, 1970

"‘"lr‘vwm.

WWW

—-r~w-—

.-

‘

Durrin, Chief
Investigations Division

Mr. Kenneth A.

Compliance

United States Department of Justice

Bureau of Narcotics and Dangerous Drugs
Washington , D . C . 205 37
Dear Mr. Darrin:

rv-mr’ww.

WW

to use import permit #2532 on this trip and an
and green copies, to request their cancellation.
both
the
yellow
returning
I was unable

Thank you

for your cooperation.
Sincerely yours,

mmmw—m-

Fink, M.D.
Professor of Psychiatry

Max

”ﬁlm
one. (2)

�</text>
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                    <text>September 5, 1970
Dr. William Tabor
A. H. Robins Co.
1407 Cummings

Richmond,

Virginia

Dear 3111,

In Istanbul, I first heard the summary data of the studies on
butaperszine in Istanbul, Furnington and St. Louis, including a most
interesting comparison of the data with that of Denber - Bente. All
Keskiner presented the data well, and I am writing to suggest that
you will find the report of special interest. I am sure he or Tursn

Itil

will
My

make

it

available.

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>September 3. 1970
Dr.

Pierre Etevenon

2 Rue

Paris

D'Alesie
14 ,

France

Dear Dr. Etevencn:
Dr. Simon introduced us in Prague. and I am writing to ask
thct you send me such preprints of your studies of computer analysis
of 886 changes with drugs as may be available. Separately, I am
sending you cepies of our recent studies.

I trust you will
United States.

visit

us in

New York

on your next

tour of the

Sincerely yours,
Fink, M.D.
Peofessor of Psychiatry
’

Max

MP:kt

�</text>
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                    <text>September 3, 1970
Dr. Paul B.

Briet

Schoutenburgst. 32
Oegstgeest, Holland
Dear Dr.

Briet:

pleasure meeting you in 033. I have discussed your
qualifications with the Department Chairman, and found him receptive
to my suggestions. Unfortunately, your curriculum vitae (description
of academic experience) has not arrived.

It

was a

still interested in working with us, may i suggest
a request for appointment, specifying the dates available,
and 3 copy of your curriculum vitae.
If

you send

My

you are

me

regards to Dr. Michelse.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>September 3, 1970
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Deer Turen,
You organized and ran a most interesting and stimulating meeting.
Most important, I admired your keeping your ”cool” despite Iany extre-

ordinary pressures, including the cholera scare: Congratulations!
Al has told me that the Friday session was most successful and I
I
specielly regret massing that. My trip to Athens was necessary, forhas
found that the estimated costs for this study (like so many others)
doubled in a year and I must negotiate once again with Washington.
I know you have had extraordinary expenses in your meeting.
Enclosed is a contribution in support of your meeting, which will in
a small way indicate my enthusiasm for your efforts.
My

best ﬁersonel regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

mf

�</text>
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                    <text>-'

“17 war”..w-vw .

.

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"

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mt.

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up... _, w. w,_n_»mwylw.,_,,., v

September 4, 1970
Dr. Adam

J.

Krakowski

International College of Psychosomatic Medicine
Plattsburgh, New York
Dear Adam,

m...

nvmw

sea-yr.-

-.-.-v;

-.

interested in your suggestion to support the Inter—
national College of Psychosomatic Medicine; but as is generally
true for our academic programs, find no funds available to send
our staff to foreign meetings. As I am unsure of our participation
I

am

in Mexico City, I must decline your kind invitation.
It was fun discussing the Academy at the Pfizer symposium.
My

best wishes for the success of the

ICEM.

Sincerely yours,
Max
.

a
31‘

‘z=-':—:.c

“’r

.x
_..

1,,

n.9;

7
:.‘._.

rw’w—‘VW-

—.

a
:

7Wy‘trm

:1

v

13,—ng-

xmﬁ'ﬂVwrm-rlrW-vwwqqqm

run“

Fink ,

w).

Professor of Psychiatry

u—ywwp

MF:kt

�</text>
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                    <text>.

"a"

m

W-m.muvww.m.

.

«71171; rams:

W.w

.

.

.

r

'

.

war". wry

«

-

wax-r

l-"WWW

'c—Iw—qm‘r‘r‘

V-

September 4, 1970

—‘

Mr. Thomas Stevens

Hi-Tor Apartments, Apt.
Haverstram, New York

14A

Dear Tom,

regret your decision to leave us, but am pleased
that your special experience in narcotic addiction will not be lost
to New York. It is our fate to be a proving ground for personnel
moving to the NACC programs, and both Dr. Freedman and I are pleased
to be able to contribute in this indirect way.
My best wishes for your continued enthusiasm for your work, and
for your success in your new association. I think you for your
interest, enthusiasm and extensive efforts on the behalf of our
patients and programs.
I very much

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>September 4, 1970
Mr. Harald Olav

Siegrist

District—Attorney

Witikonerstr. 468
8053 Zurich, Switzerland

Siegrlst:
Enclosed is a transcript of the NBC-TV program you requested.
pleased with your interest. I returned from EurOpe last week

Dear Mr.

I am
where I found much concern with drug abuse, including heroin.‘ This
tragedy which besets our nation, seems to be contagious for Europe.
Hopefully, our efforts will be supported here and successful in a

short time.

Sincerely yOurs,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>September 4, 1970

Peter Hales:
Ilnd Clinic of Neuropsychiatry

Dr.

Balassa—u 6

Budapest VII, Hungary

Dear Dr. Halasz:
I

regret

to Budapest

we

came

did not meet in Prague. Your
too late to allow a change in

letter of invitation

my

plans.

In the absence of a visit, may I ask that you send me a statement
activities,
of your interests, description of your hobbies and cultural
of
me
names
the
would
give
you
Also,
political iffiliations, etc.?
them
ask
to
may
work;
who
you
describe
or
can
your
three referees
write directly to me. I know Dr. Boszormenyi and perhaps you could
obtain a reference from him.
I look forward

to hearing

from you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 4, 1970
Dr. Finches Borenstein
Hopital Psychiatrique de

71, Quai Branly
Paris VII, France

Villijuif

(Seine)

Dear Pinchas,

I missed you in Prague, hoping to see you again. The
meetings were quite interesting, although too large with too
many simultaneous sessions.

Recently, I became interested in sulpiride when a friend
mentioned your studies suggesting that this compound may not
As you know, I am most interested
fit the EEG classification.
EEG
studies in new drugs, and I am writing to ask
in continuing
you would favor me with some data. Hey I have any recent
if
summaries of your work with sulpiride? In what cases do you now
—

find

it

useful,

and

at

what dosages?

are the profiles of sulpiride in patients?
volunteer data been reported?
What
Do

you think another

I will be graterl
wife and associates.

EEG

study

may be us ‘ul?

for your advice.

My

best regards to your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

Has any

�</text>
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                    <text>r___.__________________________
g
,

E

E

;

Septeaber 4,
Dr. Ralph Dudley

1970

Mlller

Research Associate
Vanier Building, Nopean St.
Ottawa, Canada

Miller:

Dear Dr.

at Dr. Mira: last Saturday, and again at your
you were not too dismayed by the disparity of
of the reconstruction of the Miras' laboratories and

I missed you

hotel.

I

the state

trust

his ebullient optimism.
You

report.

Many

full

and Heinz mentioned the availability of the
I trouble you for a capy?

May

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psy. iatry

Max

Mszt

'

LeDain

�</text>
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                    <text>September 4, 1970
Dr. Sidney Melitz
York State
722 West 168th

New

New

Psychiatric Institute
Street

York, New York 10032

Dear Sid,

pleased to nominate Jan Volavka, M.D. for membership in3 the
Society of Biological Psychiatry. I have known Dr. Volavka for
and
years. He trained with Jiri Roubicek, Creutzfeldt in Munich
and
psychiatrist.
Scott in London. He is a fine electroencephalographer
I

am

Roubicek
My

is

a

logical seconder.

best regards.
Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

Mszt
0110.

�</text>
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                    <text>September 8, 1970
Dear Josh,

Enclosed is a proposed subcontract for the Athens
study. I have taken the model suggested by Mr. Graduall, and added
the modifications that I believe would cover our specific problems,
expenditures for personnel and volunteers in Greece. I have also
decided to append a full copy of the general provisions, some of
which apply Specifically and the others should provide some
evidence of NIH intent for anyone interested in reading them.
I would anoreciate your calling me at my office if the
changes are minor; and if major, I would appreciate yourrmaking
the appropraite amendments and I will send a messenger to pick

up

the corrected text.
Many

thanks.
Sincerely yours,

Max

Fink,

M.D.V

�</text>
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                    <text>September 8, 1970
Dr. Monique Broudy

Division of Narcotic Addiction
and Drug Abuse

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Dr. Broudy:
I am writing to request an additional supply of marijuana for
our experimental program supported, in part, under NIMH 13172 and
13358. We have recently completed one study of marijuana and
perception in volunteers. A copy of the interim summary is enclosed.
In this study we used 46 Grams of marijuana, and have 54 Grams
remaining.
‘

In the next study, to begin October 1, 1970, we need 80 Grams
minimal. and would prefer 100 Grems to account for repeat sessions
and dropouts.

request an additional 50 Grams of the same marijuana, 2-PF;§1
(Mexican female, 1969, A9THC81.5% and cannobidiol, 0.12%). If this
is unavailable, we would ask for 100 Grams of equivalent material
and return the remainder of 2-PF-Bl.
We

As we have had recurrent difficulties with our nail,
request that you ship these supplies registered mail to:

Dr.

Max Fink
P. 0. Box 269
Great Neck, New York 11022

Thank you

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

may I

�</text>
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                    <text>n'wAv‘W-w'v

"muv Wu"! aw-nmr

”WWW”

w. .‘s

Hwy—m u

mew—i

"7“... r—‘W‘wl-..u.-~.-.~.m.

.J.

_

w»

...vvm..,,-._._.m_m

_..,,,.;........,

.

v

.-.

7.-"

,_

September 10, 1970
Dr. Philip Tannenbaum
Smith Kline and French Laboratories
1500 Spring Garden

Philadelphia, Pennsylvania 19101
Dear

Phil,

I must ask your indulgence in correcting (for the second time!)
the summary and conclusions of our report, "EEG Profile of Oral Doxepin"
(IV: 7-21-70). Enclosed are five copies of the revised text which
should be substituted for page 13.
The change is occasioned by my doubts that doxepin can be fitted
into the 1969 classification scheme, and I am considering further
studies to clarify the data. It will allow me some flexibility in

the development of this classification.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

enc. (I)Revised

PG. 13

m.

.

..

.

..._

...,,..

H

‘

.,

�</text>
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                    <text>w-

I'd-“Yi'ﬂ’v‘

CW?

....

_

v.9

'Im'wu'v

'r|:\&lt;':‘-V'

«unww—MWY—

«yum ‘7’
.

_

Y,

._.,..,

_~-.

..

.IV-‘yﬁv"-n

new

«Vaultsv‘

.

..

September 10, 1970

v“

VIP-"Wm“

....-.-..wr. Fm

Dr. William Tabor
Robins

A. H.

1407 Cummings

Richmond,

Virginia

23225

n—rv

y-u-uwv‘uw',

mw-w

Bill,

Dear

I have read the protocol of AHR 3000—E (butaperazine) dated
6/10/70 with interest, and believe we can participate in the
assessment both of the bioavailability and therapeutic equivalence
of BPz tablets and concentrate. I find one serious problem with the

design.

'"W'JWII.

:-

.wvwns-w—wwarw-m-v

'v"

“wavy.-

'1
‘

$1:me

for

it, each subject is to receive tablets SP:
transfer directly to concentrate BPz, at the
dosage as tablets BPz. The assumption is that the equivalence
As I

WV'VX‘I'I'Fﬁ'AHWW'm

6

same

understand

weeks and then

of the

two formulations will be assessed by the continued improve~
nent of the patients.

Such a conclusion is valid only if psychotic patients deprived
of active antipsychotic medication would uniformly relapse on drug

withdrawal. But such is not the case, and on cessation of antipsychotic medication a number of patients may maintain improvement
for many weeks after withdaawal (see Gottschalk gt_gl;, Comp. Psychiat..
11: 123-140 (spec. pg. 135]; Kamano, Psychol. Rep., 19: 743-749. 1966;
Gittelman et a1., Psychopharmacology A Review of Progress. 1119-1154,
1969). Thasy“f? patients treated for 6 weeks are given placebo, not
all will relapse within the next 6 weeks.

this reason,

that the patients randomly
concentrate 8?: first; and for those who
stabilize in 6 weeks, transfer to the other formulation for a
second 6 weeks - avoiding the objection raised in my mind.
For

receive tablets
““mr.1i1-v

My
-

BF: and

I would suggest

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

up-

u.

“4..

..w--

�</text>
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                    <text>m—m

WW.w-m-.~._—w

-..

71

&lt;w"

A

“muwmw

September 10, 1970
Irrr—Jw

rum—“Wm“-

Dr. Norman

Dear Norm,
The doxepin pamoate

ww‘wwvl'v-v‘

~u-

2-w-wwrwwv—mmm-vvu-«w

W.

Pitts

Chas. Pfizer G Co.
Groton , Connecticut

protocol

was

revised following our

interesting discussion. I also found it advisnble to revise the
doxepin EEG report (IV: 7~21-70), 1 copy of which I gave you.
Please substitute the enclosed page 13, as revised, for the

page

is

5:1,

and no ”purer" doxepin

I was

your copy.

other preparation of doxepin has isomers in a ratio of
is aviilsble. For more refined isoner,
referred to Pfizer, Inc.

The

It was a pleasure to have you
expedite our studies this year.

visit,

and I

trust

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

we

can

�</text>
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                    <text>September 11, 1970

Dr. Adrain Eisel

East.St. Louis,
Dear Dr.

Ill!

Eisel,

Thank you for your kind invitation to address the
October 1.
St. Clair County Medical Society on the evening of
"Drug Abuse",
of
While I would be pleased to discuss the subject

is a religious holiday,
I find that the date selected, October 1, celebrations.
and I will have to participate in family
faculty,

Dr.
studying and

I would recommend another member ofin our
Arthur lake, who has many years experience
for this
treating opiate dependence, as a substitute
narcotic antagonists

If I

may,

has studied methadone and the newer
from
and may answer the questions of the members of the Society office
this
reached
He
be
at
can
thh vantage point of experience.

evening.

He

or at 212-360 6748.

would also suggest that his expenses and an
honorarium of $150 would be apprOpriate.

I

is

thanks for your invitation; and if my suggestion
another
unacceptable, I would be pleased to visit St. Louis again at
Many

date.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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:v-ItF.’

.rvmw

'1'.~—'

-s~

”awn-v

...

”WA”...—

-.x--,-':-I-r-r\-x-~IKY‘VA"II7

September

ll.

1970

Dr. Rafael.R. Gamso

Director of Medical Services
Narcotic Addiction Control Commission
1855 Broadway

New

York, New York 10023

Dear Dr. Gamso,
would be pleased to participate in the NACC training
sessions and can join you on October 15, or November 19,
conveniently
preferably at 10 a.m. The subject should most data
of our
and
laboratory
the
of
overview
clinical
be an
by NACC.
supported
in
antagonists
narcotic
research programs
A more jazzy title is the one used by Frank Field - ”Immunization
Against Drug Addiction".
We

A

more

detailed report

on

the clinical aspects of our

studies can be obtained from the project directors, Dr. Arthur
Zaks (naloxone and L-alpha-acetylmethadol) and Dr. Richard
Resnick (cyclazocine). If you wish their participation, they
can be reached at my office (5 E. 102nd St., New York, New York
10029).

Thank you

for your invitation.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kt

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,.

\\

g

‘

YR

,.

,vvmrgpu

September 14, 1970
Dr. Norman Pitts
Chas. Pfizer G Co.

Groton, Connecticut 06340
Dear Norm,
I have read with interest the proposed guidelines for evaluating
novel anti-anxiety compounds (received 9/8/70). Such an outline reflects

prevailing practice, but makes no effort to either justify the practice
as acceptable nor to highlight the hazards of our present practices.
As

on

a statement of present procedures,

special studies is interesting

evaluating methods

now

it is

acceptable.

The

section

and provides clues as to novel

under study.

Some specific comments are found on pages 3 and 4.
In the introduction, the marked paragraph may be omitted as gratuitous; and on
page 4, the section should be omitted since the NIMH—ACNP report is
and should not
a discussion of problems and issues, not guidelines
be so dignified, especially since the documents are not completed.
Would it not be premature for the PMA Committee to incorporate an
unpublished report before it is issued?
—

The initial single and multiple dose studies should be done in
paid volunteers, to assess safety and not in pagients (page 6).

qualities
that

is a statement that

would describe the steps
a potentially effective
trials,
The animal pharmacology which is used; the
(chemical and pharmacologic) of known anti«anxiety agents

What I miss most

leading to clinical
therapeutic agent.
seem common

and

criteria for

to this therapeutic group;

and

especially, those

For example, all
accepted anti-anxiety drugs are anti—convulsant, sedative (hypnotic),
produce seizures on rapid withdrawal and tolerance. But other
drugs have anti—anxiety qualities as various “anti-psychotic” drugs,
some anti—depressants, calcium salts and such,additional substances
as ethyl alcohol, opiates 33g,

aspects of present drugs that need improvement.

-

�Dr. Norman

Pitts

~.2—

September 14, 1970

In making these suggestions, I am reacting to the limited goal
of these notes - i.e., minimum guidelines for clinical assay; as
perhaps too limit33~?or industry. By broadening the document to
include animal pharmacology, criteria for early identification, and
suggesting that the drugs are symptomatic (therefore, not easily
categorized), PMA may highlight the complexity of the issues and
minimize the utility of 1970 issued, rigid ”guidelines”.
I am also concerned with the lack of supporting citations for
of the introductory statements. A detailed, academic presenta—
tion would be a more powerful statement.

many

Thank you

for the opportunity to read this

document.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>”mug-wry . v-tu" ""‘y

r,

‘0 "mum-war:

_...

wr‘yivzvm'.“ wwv‘

rw:

September 16, 1970
Dr. G. G. DeAngclis

Pfizer, Inc.
235 East 42

New

Street

York City

Dear Dr. DeAngelis,

Please accept

my apologies for not appearing at the
I found that it would be very difficult to make the
trip today, I called John Kramer and his willingness to substitute
on my behalf made it possible for me to partially satisfy my committment.
I trust he served and that his presontation was acceptable. If he
did not tell you, he has been a student in my laboratories and I

symposium. When

pleaood with the work he has accomplished, particularly in
amphetamine research. Indeed, my presentation would have been a
am

distillate of his papers.

Thank you once again for your kindness in inviting
my participation, and I look forward to meeting you at the New York
symposium.
'

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>September 17, 1970
Dr. G. J. Sarwer-Foner
613 Cote St. Antoine Rd.
Montreal 217, Quebec
Canada
Dear Gerry,

Since returning from Europe, I have been swamped by reports
due and projects in distress, and find that I cannot attend the
October meeting. Knowing your history, the meeting will be a fine
one and I will regret not having participated.
My

best regards,

and I

trust

I

will see

you in the

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

fall.

�</text>
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                    <text>m

Iw'mwvm

WWW”

September 17, 1970
Mr.

Earl Ubell

CBS—TV

51 West 52nd
New

York,

Deer

Street

New York

Earl,

While I was only able to see the first half of the series,
A to z, I was impressed that your text was a clear exposition of the state of our clinical knowledge of drug abuse. It
was a good job, and I am writing to ask whether a typescrlpt,
Drugs A to Z, is available for us?
Drugs

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

�</text>
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                    <text>September 17, 1970
Dr. H. C. B. Denber
Manhattan State Hospital
Ward's Island

New

m-VIV-

New

York 10035

Dear Hy,

Enclosed is the revised draft of the centrophenoxino study,
your suggestions included. would you like to send this
to the manufacturer, or to publish, or?

with

all

have been asked to expand our lectures in biological
lst year residents at Met. I would be pleased if
you would be willing to give one lecture (Fridays, 19-11 a.m.).
I have asked Dick Abrams, who is coordinating the schedule, to
call you for a suitable date and topic.
we

psychiatry to

Many

thanks.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

cc:
“wr-

Wr-r—rmmw-‘vmﬂvm‘vr

York,

one .

R. Abrams, M.D.

�</text>
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                    <text>September 17, 1970

Earl Ubell

Mr.

CBS~TV

51 West 52nd
New

York,

Dear

New

Street
York

Earl,

%ile

I was only able to see the

first half

of the series,
clear exposi-

Drugs A to 2,1 was impressed that your text
tion of the state of our clinical knowledge of drug abuse. It
was a good job, and I am writing to ask whether a typescript,
Drugs A to Z, is available for us?
was a

-

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

.

�</text>
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                    <text>September 18, 1970

;

Mr. Fred Brunner
IBM

Corporation

475 Northern Blvd.
Great Neck, New York

Dear Fred,

In view of our purchasing the IBM 1443 on this date, please
IBM maintenance agreement #HlOOG? to include maintenance

revise the

on the 1443

effective this date.

Please revise our monthly charge for September rental and
maintenance of the 1443 to reflect this purchase.

will issue a new rental agreement for the
effective October 1, 1970.
We

Thank you

keypunch alone

for your cooperation.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>September 18, 1970
Control Data Corporation
575 Lexington Ave.

New

York, ﬂew York

Attention:
Dear

Mr. Pagano

Sir:

RE:

Customer #4596

Effective this date please cancel our rental agreement

on the 0217

digiscribe display.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

cc: Hr. Tozzi
Mr. Tozzi:
CDO

requires

satisfactory.

us out of

it,

us

to notify

them and

this letter should

be

contract has a 90 day clause. If you can get
they can take the scope immediately.
The

ELF.

�</text>
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                    <text>September 19, 1970
Dr. Charles Shagass

Eastern Pennsylvania Psych. Institute

Philadelphia, Pa.
Dear Charlie,

It will be a pleasure to participate in the ACNP Study
Group III in December, and I would like to give a progress report
on our drug classification studies, focuasing on methodological
issues. lzere is one problem, however, and that in a potential
conflict with a symposium organized by Al Freedman on Cannabis.
As a

title:

EEG’

Profile Analysis of Alert

Manfor

Psychopharmaoology: A Progress Report.

As additional participants, perhaps you would consider
Anthony Kales,aﬂilliam Dement and Ian Oswald. These are very active

in

EEG

classifications of sleeping man.
If you have limited funds, I

wonder

if

Bradley

is the

best resource person. Have you thought of Oswald or Borenstein ?
Philip does little psychophnrmacology relevant to human clinical
problems, while Untold and Borenstein do.
An

abstract will follow shortly.
My

best to Clare.
Sincerely yours,
Max

oil

Fink, Md).

Professor of Psychiatry

“n

on”

�</text>
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                    <text>m,

-Fr,”

vm-

..

mm,

.w. .9.

W‘—

m...ﬂw.{_,_u .9... ~

~

.“r .mw Wurixswm”0...,”am

u;

..,., W...» “raw,”-

.

r...

.,,,__.,_.,,..,

.

.u v..-—,-.

,,.

a

Mgr...

mm...

arm-"1‘1.

.

.. —.u~

«v-

”14‘ -»

‘
’
‘

'
“
W
.

""

*W"

‘
mm

'nwnmmnzz‘-'rwww

Governor Nelson Rockefeller
Albany, New York

September 21, 1970

Dear Governor Rockefeller,

In your campaign for re~election, your opponents are
NACC program as a failure. In one regard, NACC has

criticizing the
shown

responsibility, in supporting studies of opiate antagonists

as an alternative treatment and prevention for opiate dependence.
.
.

“rt?-

y‘a'vﬂ'mrlv"

‘45.";

_

'm,

’EZfWE.Vr"hY:'1-$'ygw1g

$7.7».

There is a substantial subcontract for the continuation
of this work before the Commission now, and if approved (as I expect
it will), may represent a legitimate opportunity for your administration
to claim public credit for an important development in addiction
research.
The antagonist studies at this College have been supported
by New York State since 1966. The subcontract is by New York Medical
College with the Food and Drug Research Laboratories of Maspeth,
Long Island. Dr. Alfred M. Freedman, chairman of this Department

of Psychiatry, is the principal investigator of this study. The
contract is now in the Commission offices, before Mr. C. Drysdale.

lame-r.

w

,

Sincerely yours,

new

-

~;
-:

“tan-mwm'nwv.

Max

9.x?

H

a

mf/

{we

Vx:,

rm,

,w¢;m7mmm;wwmw

.mwmwxlm'lﬁe

_

Fink, M.D.

Professor of Psychiatry

mm

&lt;

.v

, on

‘-

‘

-- .,

var ,,,
.

-

»

.1

�</text>
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                    <text>September 24,

197G

Administrative Secretary
Administratiye Office
American Society for Clinical Pharmacology
and Therapeutics
1718 Gallagher Road
Norristoun, Pennsylvania 19401
Dear

Sir:
I

writing to sponsor the nomination of Ali Keskiner, 3.9..
I have known him since 1964, when he
joined the Missouri Institute of Psychiatry as 3 research fellow.
for

am

membership in the ASCPT.

He is a well trained clinical
with particular
interest in clinical pharmacology. psychiatrist
He has published more than
15 experimental
papers, and is an expert in the therapy of

schizophrenics.

It is

a pleasure

to

recommend

his election to

membership.

Sincerely yonre,
Fink, H.D.
Professor of Psychiatry
Max

HP:kt

�</text>
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                    <text>September 24. 1970
Mr. John F. Amarosa

Eastern Regional Service Manager
Corporation

Ampex

75 Commerce Way

Hackensack,

New

Jersey

07661

Dear Mr. Amarosa:

Separately, you will receive a purchase order in the amount
of $733.00 to cover repairs of Ampex SP 300 Serial #366436 and
Channel

(AMPEX)

#7.

Per your telephone conversation this morning with Dr. Volavka,
enclosing samples which you requested. When you are ready
to return the SP 300, please let us know in order that you may
I

am

pick up the other amplifier at that time. The amplifier is located
at Metropolitan Hospital, Department of Psychiatry, 15th floor,
room lSAQ.

As

this is

a locked ward, we

of delivery in order that a
Thank you

member

will need

of our

staff

can

advance

for your assistance.
Sincerely yours.

Professor of Psychiatry

kt

notice

assist you.

�</text>
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                    <text>A

rv‘vvr

ImWr—V

1w-|"‘

a."

Mr. P.

TO:

Mas

FROM:

SUBJECT:
.

-m

vw—wrwng,yn—-

ru—l

"-rmra—

N.

,........

.
~

”w...

,.._.,...,.v‘.-n,._,wwy.-

.

,

-gvm~.rvywnrv-.

m

...—r—

—'

»
vac-x-

Terri, Purchasing

DATE:

September 24, 1970

Pink. H.D.
Contract with Hydrosystens,

In June

PG

0505442

negotiated a contract with Compro-Hydrosystens to
purchase a printer for our IBM 1300 system. The purchase price was
defined in relation to the compatibility with the remaining components
of the 1300 systea. In order to assure this coapliance to the equip-out
description. we added that the contract would be operative only if
the software was fully coepatible with our system.
During the sue-er, various coauunications between the aanufacturer‘s
staff and our own suggested incoapatibilities in software. 0n Septeeber 16,
1970 they indicated that proper functioning according to their contract
would require an additional expenditure of 33,000 and sons indefinite
delays in eating the systems coapatible.
we

On September 18, Dr. Shapiro, at no request notified Hydrosystens
(Hr. spadefine) that the revised contract proposal was unacceptable.
I requested cancellation of the contract that day with the understanding that the terns, both in tine and cost, would not be set.

Hydrosysteas re-opened negotiations today (Septeaber 23) by
indicating that they were able to sect the contract as specified
in June (without the prograa changes). This was unacceptable and
Mr. Spadefino then indicated we would be liable for cancellation

cut’

0

wwwv-r-

www-

n-wa

,—
A:
,.

wwwmmahmw

'm

pave

It is clear that the discussions of August and early Septeaber,
culminating in the revised contract represented a renegotiation of
contract (as of 9/16] which we did not accept (9/18) and which were
not acceptable today (9/23).
Neither a cancellation penalty nor a request to fulfill the
contract without additional costs are acceptable at this time.
Our cancellation is not based on the price alone. but on
the determination that the software problees were significantly greater

Addendua.

initially stated.

than

Wzkt
cc:

1. B. Schwarta (Ref. 41-382—‘)
Mr. T. Bannon

�</text>
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                    <text>wwwmww'n’mww

'm‘mm

Hum-er

-

Wiewl‘m’v'wxum'mwr'zs-v

WWW
,

rnxmvpmvvurv-wv;

«nun..- rrmw ~l4—1Vauvs-nm‘w

,

,

w4my

Septenber 28, 1970

'U-vwr'rll'r

“wanna":

Dr. Virgil A. Place
Ales Corporation
950 Page Mill Road

Pele Alto, California 94304
Dear

Virgil,

The prosteglendin sessions were most interesting and I
went to thank you and Peter for bringing them to my attention.

Enclosed

is the marijuana pro-print

study is not yet in press.

you requested.

The

In reviewing data in my files on the relative potency
of antipsychotic agents, with a view to their use in 1 long
acting formulation, 3 table of relative dsily dosage ranges
shows the following:
Fluphenazine
Buteperezine

w

Trifluperesine
3Wf—WWWWWHVW

Thiothixene
Relaperidol

Stelezine

Nevene

Haldol

5-40

10-60
15-40
10-40
15—45
2—4

we

look forward to hearing from you.

Sincerely yours,

N‘WWWHYWW'W'HG

‘

”‘e‘

Fink, M.D.
Professor of Psychiatry

Max
W;

THE

M?:kt

_

.'

‘

H

V'w,,n,.

(mg)

Serpesil
I have selected representative drugs of different chemical classes
from s larger table.
Reserpine

‘-'

Prolixin

Repoise

�</text>
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                    <text>September 28, 1970
Dr. Edger Grunweldt
Geigy Pharmaceuticals

Ardsley,

New York

Dear Ed,

Enclosed is e xerox copy (with Table I corrected) of the
published report, "Ketiprenine in the Therapy of Depression in
Outpatients”, as published in Pszchosouetics, 11: 342-346, 1970.
Again.

my

thanks for your interest in this study.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mszt
0316 .

�</text>
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                    <text>September 28, 1970
Dr.

J ack

Preund

A. H. Robins
1407 Cummings Ave.

Richmond,

Virginia

Dear Jack,
Dr.

Pierre

Simon has

candidly cnswered my inquiry regarding
the enclosed articles. I have read them,
and tend to agree with Dr. Simon that the data is uninpressive.
It is particularly disturbing that the "best" results are in cases
in which other drugs were simultaneously given.

sulpiride,

and sent

me

I am disappointed with Borenstein's

had a chance to read the

than his

earlier reports.

If useful to
I

data,

now

full report. These data

that

seem

you, I will write to Dr. Nourricier.

will send the other reports, as

I receive them.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt

I have

less rigorous

�</text>
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                    <text>—v,_—A

war-1w."

“nu-mu;-

'ij

"ea-”warp

'“““

Septenber 28, 1970
Dr.

Pierre

Simon

Centre Universitaire

Pitie-Salpetriere

91, boulevard de l'Hopitel
Paris (13°), France
Dear

Pierre,

Thank you for the articles on sulpiride. These were
most helpful, and as you suggest, the data is indeed uninpressive.
An EEG profile analysis would not be sufficiently helpful to reply
the expense and effort.

For the

will restrain

Copenhagen, I hope the Program Committee
the ehairnan to, at most, two parallel sessions!

GIMP

Many, many

in

thanks for your kindness in sending the articles.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                  <elementText elementTextId="103353">
                    <text>.‘W-mvW...

-.

v

7.-

er

"1.7,...
r1-~.J“... mv .. w”...- w "w... .. as
.

.-

W

.
wJ12

, v5.

.
w “cu-u.

,

‘~ve‘4‘n‘7lww'a

.

.

mum.

vim—"vow“: .._--,........n..v—yw.....7,.

in, ...,,,,...___..,,‘"r_

_

,
..

_,__,

3“").

,~

September 28, 1970

.
envy—l“,:,.ﬂ.,mun_r,ﬂ,m,

Mrs. Pat Walter

Brain Information Service
Center for Health Sciences
Los Angeles, California 90024

UCLA
”mgr—raw

.

-.

-

run,

Dear Mrs. Walter:

I
a

I have found

.,
.m—v

.v—r

m—

,vs-wa

..

earlier citation lists helpful

to request cepies of the following:

«7

20.0, 20.1
22.0, 22.1, 22.2, 22.3

W",‘Wlw~

..-gs

W'

w.

‘
12‘.»

.

runwa-

vaqv-

mt
:32a

81"”m-‘Wmmﬁu

WW'I'P’WW‘

writing

16.1d
16.5

.

m

w

and am

In 1964, I published a "Bibliography of EEG in Human Psychopharnacology" (Blsevier, BEG supplement 923) and have maintained
It may be useful to attempt a decennial
my files since then.
addition in 1972 (the listings ended 1962). This will be a large
task, and I an writing to ask if the BIS can cooperate. If so,
I should like to visit on my next trip west.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

YWWW.

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                    <text>9

..

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H.737-

w... )Iusl‘l'w‘umw‘1Y

wnv,~mu-vmmmza.

.

w ,

«,H.“

~._v.-

w:

“‘-

"wﬂw

WWW-Av."

r
-.
&lt;

.

”mu—amu-

"a...“

September 28, 1970

um:.-v~m.-m.«-.

uwz‘.n'

IW‘V‘

Wm

Gmmm‘

mim

W

Dr. Richard H. Roch

Associate Professor of Pharmacology
Dartmouth Medical School
Hanover, New Hampshire 03755
Dear Dick,
Thank you for the outline of the 1971 Aspen meeting
program. Both Itil and I will participate. Shagass is unable

to attend but suggested either Heninger (Yale) or Seletn (Univ.
of Missouri) as capable alternates. Before inviting them, I
wonder if we don't have enough with five speakers? There are
2 hours allowed and I think we prefer discussion to another
speaker.

;

seem fine.
one for me.

Titles

enclose

Looking forward

to

I have asked

Itil

for

an

abstract,

Aspen.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

and

,_

m’- u—wvv-w.

1-

:

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m.

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                    <text>r -W-

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u

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mm

, .m

“Mm...”—
,

,

.

~v——-‘

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warm-Vane!

September 28, 1970
vm‘v‘vmmw

Dr. Turan

M.

Itil

Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139

-

Dear Turan.

Enclosed

and the forms

is a copy of the letter from Dick
for the conference registration.

Would you
My

scrape up an abstract and send

it

Roch;

to

best to Ellen.
Sincerely yours.

‘

r:
_‘

"w

Pink, M.D.
Professor of Psychiatry

Max

"ﬁr

-.~«

”3“"

mwo,ﬂ.,r‘

riwwtpwunr&lt;njuxw

v»

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I'm

3

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my

answer;

him (or no)?

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v—pr

rw'

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,

,

V

I-N.‘wnt-n'nv~wrn1lrmv\.v-'-

P“

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1,,”

.,

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‘,.._,..‘

September 28, 1970
rwwwmv“

Mr. Robert L. Marlin

Sandor Pharmaceuticals
Hanover, New Jersey 07936
Dear Bob,

I have read Loo Goldstoin’s report of his EEG analysis
of 42,548 with great intorost. The data is not inconsistent
with our own, and should therefore, be useful to you in your
3

,
r-

1",

decisions regarding this compound.

~—

vwn‘l

Thank you

for the opportunity to road this report.

w’i“|Wl-m-

‘

Sincerely yours,

Wam-m-w—u—wm

Fink, M.D.
Profossor of Psychiatry

Max
rw-

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                    <text>_,

,

V

mun.

v

.

_

,. me.

»,/-..‘..~

,

my

-v‘

.
..

vrrwm”w‘puu’(\ﬁ“pew=r:fl

September 28, 1970
Dr. Richard H. Runser, M.D.
Medical Director
Wallace Laboratories
Cranbury, New Jersey 08512

Ire":

14.

Dear Hank,

inv—

“1.1m.

I was pleased to have the opportunity last week to discuss
the continued evaluation of W 2354. While I am most interested
in applying the EEG profile analysis methods, it seems that such
a study now would not serve your long-term interests. As we
discussed, it may be more profitable to continue clinical studies
in arthritic patients, at various dosages below those reported
from New Orleans as producing gross

CNS

effects.

In these subjects, the concurrent sampling of EEG, with
suitable attention to time of recording, dose of w 2354, electrode
montage and amplification, will provide additional information for
an EEG profile study. It may be useful to have the EEG records
from different centers obtained according to a common protocol,
particularly if you wish us to review the records for evidence
of central effects.
We will be glad to cOOperate, and both discuss with the
electroencephalographers, our recording needs, and review these
records on your behalf.

If this project continues, it

would be most useful

if we

could establish a consulting relationship, which will permit you
to call on our facilities as the project may require.
My

best to Milt.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

van—w..avmvmw-w-rvw-

r.‘!‘r~' .. w“ .__

�</text>
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