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                    <text>haw ..,._.....w TE“... .7, he}.

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W , m1.

.

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we“

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.Wz-Wramw qua Na: wu-r- ."r—Fryr-IIWUI':E¥L

,

-

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,-

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-

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newmwxm”.

"WWFN‘M‘-

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i
WW“

TI'D‘CI-I'

.
VJ.-.

Wnimrﬂm

March 25, 1971
Maw

amnmwn-uw

.

nun

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

w&lt;vsw.u~;mm.w~r1

to receive your letter and find that you are so
active. There is a great need for data on the incidence of drug
use, and a sample of 5000 is a good one, although it can be criticized
as too large for the purposes of the study. Ybur solution, to check
every 10th booklet, is probably a good one not only for your reason
of practicality, but the redundancy that will probably result from
such a large sample in a basically homogeneous population (i.e.,
male, AF, 20-30, education above 8th or 10th grade, etc.).

It

1w

-

rm

was good

—

suggestions about the questionnaire. The use of
cut-offs at 18—29, 29:25, g§730, ... provides confusion and
ambiguity. Perhaps it could be clarified. (The study may be of
sufficient interest to NIMH for you to get a small grant for
keypunching and data processing.)
I have

it
1...

...

~.A..K.-m,,..vl

u

w-—IW1'FJ:-——.-.\u~vu-n

qmm

u

m!l-&gt;-'V5)F'"V’.Irv1hlulw-nrw

r
-—-

.&lt;
-

r»

’WJKa-v‘rl'"

some

The data on the Zung

to Stanley.

scale looks satisfactory,

and I

will give

Since last writing, I have assumed responsibility for 2 floors
we have begun some
at Kirby Manhattan Psychiatric Hospital, andNYMC
residents in
supervisions of the staff. There will be 4
4 month rotations beginning July 1, in addition to the Kirby staff.
This provides a nucleus for patient care. We even have some funds
for supervision and consultation, and this is reasonable as a

beginning.

The Methadonization of NYC is increasing rapidly and even
G.P.'s are in the act. Soon, methadone will be recommended for
everyone and the two logical cheap resolutions will be touted:
free methadone from selected local M.D.'s then from alcohol

distribution centers (bars). But, our studies of the antagonists
continue, although we are more actively studying marijuana.

"wn'nu \J"!

a:

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�v»

r

-r:: —\ «a»

2x197-.. Wu”

A

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&gt;

V

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~u-

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mjr’sr'U'av-«W

-.-~v-~mm,-vﬂ-‘~-":W' ’WAWM'HJ‘L:qv

Dr. Levine

,

,

,-

~2-

—

'lin-Afn'."w"cram «my

ruﬁre-Tn-m’"

-

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r :-- w

March 25, 1971

Dick's studies are progressing well. We have established a
consulting relationship with a chemist for his spinal fluids. Mickey
has sent me a protocol for the continuation of the studies of lactate.
any studies you wish to undertake at Kirby? As I
wrote to Mickey, it may be helpful to do some protocol writing now
and suve time later.
Are

there

pass your letter on to Stanley and Dick, and hOpe they
I'll
answer you soon. Will I see you in Weshingtoa in May at the APA

and 38??
Hy

best regards,

and keep up the good work.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

.
~..-

-~—u:-—.y

..-

.

Mszpt

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                    <text>twctmv

»

q..«...w.—

4.

'&lt;Iy'w'—-

‘
v
..

a...“

March 26-, 1971
Dr. Jerome Levine

National Institute of Mental Health
5454 Wisconsin Ave.
Chevy Chase, Maryland 20015
Dear

Jerry,

are pleased to enclose a copy of “Computer Aided Interactive
Psychiatric Diagnosis Programs". The volume contains the logic and
programs in PL~1 (DOS) which are Operational on an IBﬁ 360/40 and
uses the CDC display terminal with digiscribe attachment.
We

There are two diagnostic programs, the BPRS of Overall and
Gotham, and the Diagno~11 of Spitzer and Endicott.
would be pleased to demonstrate these programs, and
the report may be useful.
We

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

ﬁrzkt

trust

“a

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                    <text>‘swew—

um‘wimwmvr‘ﬂm

wryﬂv...”

_,,_.V

AWN,

_

Twﬂw

,

March 29, 1971
Dr. Sherman

anfer

Associate Dean
Sinai School of medicine
Fifth Avenue and 100th St.

New

York,

New

$6?)
4

1:0

Mount

\

York 10029

Dear Dr. Kupfer:

f9

have been asked by members of the Mbunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment or opiate dependence.
We

would like to cooperate with reputahle scientists who may
contribute to our understanding of the opiate dependence problem.
If
I would like to assure you thht the study has been endorsed
by the Research Committee of the ¥“New York Medical College, that

We

it is undertaken in the facilities of the Department of Psychiatry
either at the metropolitan hospital Medical Center or in our

laboratories at 5 East lOanJMStreet and that all precautions
whichm deem necessary for the protection of our patients have
and will in the future, cohtinue to be taken. The amount of
heroin varies depending upon the need of the subject and design
of the experiment. The amount varies from 5 to 75 mg i.v., usually
given in 2cc of Saline within 1 minute.
At the tine that Dre. Pusskin, Aledort and Gutfreund visited
me, I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the conplexity of the questions, perhaps

we should ask/the

assurances of the appropriate authorities at

your school that: the protocol has been approved by the
appropriate committee of the Mount Sinai School of Medicine; and
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max
‘

,

—Tu

ups-In":- qwn’ " “ “any“.

Mszt

k

�</text>
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                    <text>Hutch 29, 1971
Mrs. E. M. Stone
591 Morton St.

Boston, Massachusetts 02124
Dear Mrs. Stone,
For the forthcoming issue of the Seminars on BUT, I would
like to instruct the authors as to the proper style for citation:

for the journal. If regular fact sheets are available, I
appreciate 9 capies.
Thank you.

Sincerely yOurs,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkt

would

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>March 29, 1971
Dr. Sherman Kupfer

Associate Dean
Sinai School of Medicine
Fifth Avenue and 100th St.

Mount
New

York, New York 10029

Dear Dr. Knpfer:
We have been asked by members of the Ecunt Sinai School of
Medicine to make available samples of blood from patients receiving
heroin in the course of their treatment for opiate dependence.
We would like to cooperate with reputable scientists who may
contribute to our understanding of the opiate dependence problem.

I would like to assure you that the study has been endorsed
the Research Committee of the New York Medical College, that
it is undertaken in the facilities of the Department of Psychiatry
either at the Metronolitan Hospital Medical Center or in our
laboratories at 5 East 102nd Street: and that all precautions
which we deem necessarv for the protection of our nationts have
and will in the future, continue to he talcen. The amount of
heroin varies depending upon the need of the subject and design
of the exocriment. The amount varies from 5 to 75 mg i.v., usually
given in ch of Saline within 1 minute.
by

At the time that Drs. Puezkin, Aledort and Cutfreund visited
I approached the problem sympathetically, and accepted their
credentials and sincerity, and assumed that their request was a
simple one. In View of the complexity of the questions, perhaps
we should ask the assurances of the appropriate authorities at
me,

that: the protocol has been approved by the
of the Mount Sinai School of Medicine; and
committee
appropriate
that any proposals sent to any third party in which we are named
or referred to, receive the prior approval of our Department of
Psychiatry Chairman, the Research Committee and Dean of our school.

your school

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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              <elementText elementTextId="47833">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>u,

M"

Wm

Hatch 29, 1971
Dr. Fred Regan
Manager, CNS Research
Upjohn Company
Kalamazoo, Michigan 49001
Dear Fred,

Since our last note, we have established a dosage for diazepam,
and begun our defined classification study of U 28,773. It should take
8 weeks for the data collection, and 2-3 for the analyses, so that I
anticipate our report by mideune.

L'ﬂm.

:.

Your notes on the duration of

action of U 23,773 are most
with
for
clear
so
duration
a
interesting,
effect, we may wish to
approach the clinical effects in a study of a different design.

A

with a flat extended duration of action would be most
powerful as an antianxiety agent. Our present problems with diaropam
and chlordiazepoxide are their relative short duration of action,
requiring repeated dosage, repeated risk of sedation, and the
development of tolerance, requiring more frequent administrations
in some patients. An effective, flat dosage regimen may avoid
some of these difficulties. Your note, that a halfwlife &gt; 24
hours would make you "bearish" is puzzling. Such a feature may
increase the risks of uncontrolled use, but may be more useful
in reducing the euphorigenic risks. The higher tithe, higher
euphorigenic action, and higher addiction liability of heroin
compared to methadone are documented. Both drugs effectively
compound

reduce opiate hunger, opiate withdrawal symptoms, and may usefully
substitute, one for the other. Yet, methadone is considered the
safer drug, with its longer duration of action. The extended duration

of action enables

some

useful applications.

Come visit New York soon. Meanwhile, even if the rubidium fever
has cooled, the enclosed announcement may be of interest to someone
on your staff.
try to be there and will send you a summary if
nouone else is able to go.

I'll

See you soon.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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                    <text>wmanw—w-‘uu

aymmnm ..,

m

,.

,,

nmx
_

=mmw.-u

.-

March 29, 1971

Dr. Julius Korein
Dept. of neurology
I. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue
York

New

Julie,
appreciate a

copy of your recent report, "The Effects
Behavior and Electrolytes", in the J.N.M.D.;
and any other reports of your lithium/EEG studies.
1

would

of Lithiun on

EEG,

I an sorry we did not neat at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthusiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her ny best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Me: Pink, M.D.

Professor of Psychiatry

Hrzkt

ran—W

�</text>
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I

.W

wrw

Hutch 29, 1971

”:8.

E. no stone
591 Horton St.

Boston, Massdchusottn 02126
Dear Mrs. Stone,
For the forthcoming issue of the Seminar. on BOT, I would
like to instruct tho authors as to the proper style for citation:
for the journal. If regular fact enacts are avnilable, I would
appreciate 9 copios.
Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>,,, may, :- wﬂ

Vl:y:'\:'

”W ~

4".“ wt.vt.~..,i-r

,-

"1.:

.~;~,,.,.“.--x—qim-wpawn:,.--_,...‘,,..,fwrw,m-mi.
A

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1,

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N.

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an

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mum.

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acm.

“1"

March 29, 1971

J. Kuhn
C. H. Boehringer Sohn

Dr. Franz

Ingelheim an Rhein
west Germany
Dear Dr. Kuhn:

we look forward to your visit in New York this spring.
Dr. Terry will make the necessary arrangements for your stay,
and I am writing to raise a few questions so that we can
provide the facilities most useful to your visit, and establish
a relationship which may be most useful.

In our laboratories, we are now carrying out EEG classification
studies of new drugs in volunteero; assays of marijuana, both
acute and chronic; and reviewing data from earlier studies of
marijuana, ECT, methadone, 233. You may wish to observe our

recording and analytic work; to participate in or undertake an
on~going study; and/or analyze the data of one of the projects.
You

also

may

wish to familiarise yourself with the analytic

- the computer analyses, statistical processing and drug
classification, either of an ongoing study, or a completed one.

programs

If

actual

of

EEG

you wish, we can also arrange for someone to review your
program needs, assuming you wished to do some processing

data in your laboratories.

With these facilities in mind, would you provide us with the
questions which you wish answered; or the goals of your visit. An
I correct to assume that you are interested in establishing a

collaborative or a consulting relationship, both for studies in
animals and man, toward identifying and developing new psychoactive
drugs?

If these questions are

indeed the focus of your

visit, it

would

be helpful if
descriptions of the principal
items of equipment now in your laboratories, particularly the EEG
you would send us or bring

w-w

5

�,

-.

raw-.1.- vanes-V:-(w

xvamv...‘ .nwuvgw,. w 5‘

y—v 300a"?

“m

-2-

Dr. Kuhn

Hnrch 29, E971

tape recorders
year, capacity for tape recording),
model, peripherals,
(make,
and
computers
model, speeds, tape size),

amplifiers
(make,

.-va~

size of

(mnkc,

memory).

Again,

I look forward to your visit,

productive relationship.

and to developing a

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
cc: Dr. E.

N. Terry

�</text>
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                    <text>March 29, 1971
Dr. Julius Korein
Dept. of Neurology
H. Y. U. School of Medicine
550

New

First

York,

Dear

Avenue

How

York

Julie,
I

copy of your recent report, "The Effects
Behavior and Electrolytes”, in the g¢§,m.n.;
and any other reports of your lithium/EEG studies.
would

of Lithium on

appreciate a
EEG,

I am sorry we did not meet at the Metropolitan EEG. Your
technician asked many questions, reflecting an enthuaiastic

interest and an intimate experience with the problems of EEG
and drugs. Give her my best regards, and my thanks for making
the evening a challenging experience.
Thanks

for the reprint.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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                    <text>:

t
k

g

E

E

March 29, 1971

Capt. Robert Levine
228 Texas Drive

Dyess AFB, Texas 79607
Dear Bob,

Stan has gone over yhe data you sent him, and his asked
me to forward the analysis - which is enclosed. He suggests
that the rigorous approach views the data as 3 sets of repeated
measures. Because of the small sample size (most probably) neither
the analysis of variance F nor the means and 5.0 are significant.
If the sample size can be increased, the test should be re*run.
Both he and I made some notations on the interview score
The suggestions are based on the lack of clarity of

sheet.

the item divisions or definitions.
‘Our

best regards.
Sincerely yours,
.1... Fink, 2.4.3.

Professor of Psychiatry

Hszt

�</text>
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                    <text>Murch 31, 1971

Dr. Michael A. Taylor
9309

murillo

Oakland, California
Dear Mickey,

it

The application is good, as
some additions.

for

far as

it

goes.

I

am

returning

Please review Pitts and McClure theory of chemistry of
lactate. ‘Thcre were some letters that were published
anxiety,
in response to our letter, that questioned the significance of a
lactate test, assigning a peripheral value to the symptoms. This
data should be referred to, and critiqued. Can you devise a test
of these criticiams?
(1)

and of

(2) You may wish to call Dr. Pitts in St. Louis (314 F0 lu4730):
and ask
tell him what you propose to do; ask him to he a consultant:
if there is any additional published, or unpublished data or hypotheses
he can make available to you.
i

If the separation of populations is successful, how can this
test be used in subsequent studies? In assessing treatment infailures,
depression,
for example? Does this test have any relevance to anxiety
(3)

or in schizophrenia?
human

(4)

What

are present tests for antianxiety—agents (animal screening,
Are there any limitations to present designs?

clinical)?

(5) I will ask Dick to describe equipment and facilities. You
should check budget, co~workers, comolcte biographical sketch, research

objectives.
(6)

Make up a

permit form to be signed by patients.

Separately, I will ask Dick and Voita Volavka to send you their
comments. Filing date is June 1.
Kirby is bloaaomigg nicely. Dick started this week. The resident
rotation is assured for July 1, for 4 NYMC residents at least, for 4 mos.
each. He will have to provide our own supervision. Staff seems adequate
in M.D.'s, S.W., psychologists and aides - short in nurses.
Have fun!
Max

HF:kt

�</text>
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                  <elementText elementTextId="103429">
                    <text>April 2, 1971
National Library of Medicine
Bethesda,

Maryland

Gentlemen:

I an anxious to obtain a

copy of the following volune which

is not available at the ﬂow York Academy of Medicine or the major
medical achool libraries in the city:
Monographicn Ans Den Gesamtgebiotc der Neurologie
und Psychiatric. Vol. 68, 1939. Stringaris,

It is

an essayy on hashish.

If this in available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

M.

�</text>
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                    <text>.

vm

, rna-zvua-A-vr'w—s -»

“mp-n

,

”Hutu—,—

waswrvmgvm

.ylw—mrngw-ppam

l-wiwwa‘x"

2w 'a-u'm' uwvvm

"(c-”u;

.

u.

an.“

‘

?:.'v":‘tw".t.r».‘|vJv-Hr...

February 1, 1971
Dr. Jerome Levine
Psychopharnacology Research Branch
National Institute of Hontal Health
5554 Wisconsin
Chevy Chase, Maryland 20015
Dear Dr. Lavina:

RE:

NR-l3358-04

are writing to request an extension of the budget poriod
for 9 months, to 12/31/71, without additional funds.
With our prosent balances, this will permit continuod support of
the principal personnel for an additional two months (to 5/31/71);
and the services necessary to completo the write~up and final
rogorts for the romainder of the budget period (to 12/31/71).
of

we

MH~13358~04

In the event our renewal request

starting data

program.

be made 6/1/71,

is funded.

we

request the

to allow continuity of the ongoing

Sincerely yours,
Fink, M.D.
Professor of Ysychiatry
Max

Principal Investigator

Alfred M. Frocdman, M.D.
Choiraan, Dopartuont of Psychiatry

Mtg. Lorraine Looker
Director, Roaoorch Administration
MP:kt

,‘

-.

�</text>
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                    <text>February 1, 1971
Dr.

Fritz Freyhan

New

York,

St. Vincent's Hospital
153 West 11th Street

York 10011

Fritz,

Dear

as I

New

I

was honored by the Association's election as Secretary,
by the renomination. It was specially kind of you to

am

describe my service as secretary as particularly useful to the
Association, for I have tried to exercise the responsibilities
of the position to the continued growth of the organization.

If the services have been of such merit, perhaps three years
is sufficiently long to judge whether stewardship should be
extended. It is unclear to me why the Association insists on
longevity in

some

positions

and not in

others. Nevertheless, I

have found the position of Secretary regarding and interesting,
but no longer challenging. While I would be honored to continue
to serve the Association, I would not appreciate another term as

secretary.
Among

the complaints of the

was the lack of opportunity

members

regarding the association

for participation.

belief that the Association should involve

It

more of

has been

its

my

members

in the program and the Program Committee; in the council; and in
the publications. So far I have been successful only in encouraging
additional participation in the committees of the Council. Perhaps,
encouraging a transfer in the office of secretary after a few years
will provide a model for other positions in the Association.
Again,

my

thanks for your kind words and recommendations.

Sincerely yours,
Fink,
Secretary

Max

HF:kt

M.D.

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                    <text>i1rﬁ‘qﬂ“.a'vﬁ&gt;r‘mevwmr)w~w"

m—mmwwa-n-cwzmwxnmmvrm-m ma w:
&gt;~;wv¢:-wr1thnz~&lt; : "1“”"“"\'.'I"WW"~‘¥NGW'Y'VWWAWC

-

—

4-

way

n“w---x1'v:

w-w

.

.-._-

-

mm

avmvmw -.-

,

um‘u—‘Wr-‘A

-—.

..
'.-

.x-

—

February 1, 1971

-"w-WWTW’”"’WWWWWF"K1'IWW’W—w

Dr.

J.

Mbndels

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and Woodland Aves.
Philadelphia, Pennsylvania 191I4
Dear Joe,

Earlier this month I submitted two copies of a contribution
One of my associates has reviewed
to EEG and Clinical Psychiatry.
the text and found a number of small errors. I have corrected
these and to avoid the expenditures of corrections in galley, please
replace the two copies in your hands with the two enclosed.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
awn”

«.

'32-

n

Mszt
enc. (2)

~~

�</text>
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.

February 2, 1971

....

f."'.‘/v&gt;.\"l

van-«u

awn-army:

4
v

Dr. Thomas Williams

National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Tom,

Enclosed is our application for continuation of support
of MH~15561~03. I would appreciate your steering it through
the appropriate processing.
Many

thanks.
Sincerely~youra,
Max

Fink, H.D.

Professor of Psychiatry

Mszt
em: a

yuan...»

.Lgﬂ‘Vr

)_r

:
-

«v.

amnmwrgmv

‘

�</text>
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.

yebruary 2, 1971
Dr. William Guy
George Washington University

Biometric Laboratory
1145 Nineteenth Street, N.W..

Washington,
Dear

D. C .

20037

Room 618

Bill,

Enclosed is the disposition report of our study
Biometric Laboratory and 3 new RPR forms.

Sincerely yours,
\Wl'rl‘"1|"-'?'

.mxr-mvnr

Fink, H.D.
Professor of Psychiatry

Max

u

.y

&lt;-r.,-cu

"WV:

MF:kt
811C 0

list

at

,_

�</text>
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                    <text>February 2, 1971
Dr. Edgar Gruuwaldt
Geigy Pharmaceuticals
Ardeley, New York
Dear Ed,

1‘W'rrrl'v

ma¢n§ﬂp~

W

W.

_

Enclosed are the interim reports of our EEG pilot study
of GPA 1714 in volunteers. we have defined a dosage
is
safe and which alters the EEG of our volunteers. The that
preliminary
data is that of a centrally active compound with an EEG profile
usually associated with relaxation and euphoria.

I have made the necessary inquiries about the
l—Dopa on EEG and have just received the citations
compare the

effects of

GP

41299 to £~Dopa.

effects of

necessary to

I trust these data are useful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

Mrzkt

�</text>
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February 2, 1971

,l
-

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,

Dr. Peter Crown
Modische Faculteit Rotterdam
m.

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Thorax Center
medical Faculty
Rotterdam, The Netherlands
Dear Dr. Crown:

associates and I have had the opportunity to review your
application, and I am pleased to offer you an appointment in the
Division of Biological Psychiatry, effective this spring. The
exact date will depend on your time schedule.
My

At present salary levels, I believe I can negotiate an
annual stipend of $12,000, such perquisites as are customary, and
a position of research associate. To make this appointment effective,
I will need to know your anticipated date to start.

I

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planning

are indefinite.

As

visit to EurOpe in late March, but the dates
soon as the dates are formalized, I will write.

my

I look forward to meeting you,

w

-

am

in our programs will

and trust
be mutually rewarding.

that your participation

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>.u'rvn awe—wk

February 2, 1971
Dr. Marion J. Finkel
Deputy Director

Bureau of Drugs
war-3w:-

Food and Drug Administration
Rockville, Maryland 20852
Dear Dr. Finkel:

letter of

January 25, is encouraging. As a
of
new drugs with industrial support
participant in the evaluation
and in attempting studies of drugs of limited commercial interest
(notably the narcotic antagonists cyclazocine and naloxone), I
would support your suggested use of seminars. There may provide
the opportunity for researchers and administrators to reconcile
differences in their opinions on the requirements for studies in
Your thoughtful

man.

I

would be

willing to participate as a speaker or panellist.

"criteria” of animal toxicology which must be satisfied
before drugs are taken to man is an issue that has provided much
travail in studying new drugs. Specifically, I have been repeatedly
The

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advised that certain trials in man were not ”proper” or "legal”
without extensive animal trials in 2 (or 3) species for 3 (or 6 or 12)
months with_a variety of pathological studies. An irony of these
"recommendations” (or ”guidelines”) is he experience that teratogenicity
and toxicity are determined as much by differences among species and
among individuals as by dose, duration, and route of compound
administration. A slavish recourse to a presumed minimum animal
toxicology profile has made much research too expensive, especially
where compounds do not have an immediate potential for financial
success.

issue that haa’been of personal interest is the improvement
of methods for the assay of psychoactive drugs in volunteers by the
use of physiologic indicea, particularly measures of the CNS like
the quantitative EEG. But this issue may be too technical for general
discussion.
An

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Dr. Finkel

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-2-

February 2, 1971

Such meetings should be encouraged, to allow additional
intercourse between administrators and reeearchers, to allay the
suspicions that have arisen aince the guidelines were first proposed.
Thank you for your invitation, and I do believe that such public
seminars will be papular and well subscribed, reflecting an important
concern of researchers, industry and government.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

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�</text>
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                    <text>‘

«:7

max. umrww:

.

W”:

February 4, 1971
Dr. Barbara Sonowski
Hoffman LaRocne

Nutley,

New

Jersey

Dear Barbara,
Dr. Itil and I have reviewed the notes for the CDT exhibit,
and have made a few corrections. Please note the addition to
Table IV, correction in Table V, and deletion on page 9.

have reviewed our

EEG data and would like to add the
which
have
we
yinformation
not published previously, but which was
analyzed at the time of the original studies. Please add page 9A
to the presentation, and to any texts of the report.
We

Thank you

for your fine editing.
Sincerely yours,
Fink, m3.
Professor of Psychiatry

Max

MF:kt
611C .

mm Muwm'lwrnww‘

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~

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m

t

f

.

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mm-

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mm

3“

‘Nr‘

February 4, 1971
Dr. Daniel X. Freedman

University of Chtcago
Department of Psychiatry
950 E. 59th Street
Chicago, Illinois 60637

Dear Dan,
Some months ago I submitted our report, "Unilateral and
ECT; Effects on Memory, Depression and EEG” for your

Bilateral

consideration for the Archives.
May I
My

(Your manuscript 0658.)

ask for a status report on your review?

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>mus-s 43:.

,

‘

r.‘

,

.

wzw

&gt;
.

-

."rurvy

w- L'n’(r-‘H"r-Y'IAr—n .9.an

.

v

raw»

7",“;

-

=

mn'T-‘J

DVWT'1T)«‘R-(".‘

—-.

~wu~

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1am.“

mun-war

mun

February 4, 1971

V,

"Iv-“.“mev-u—mm-IW'"!

2

f,
.k.

“Ya—rm",

Dr. Michael A. Taylor
9309 Murillo Avenue
Oakland, California 94605
Dear Mickey,

thanks for your warm and enthusiastic letter.
receive your acknowledgement.
to
delighted
Many

I was

g"

my

As

~w

W—

'rv'

my

air.

.-

"WWW

‘1'

plan

some

details

for the projects, it would be most helpful if you would
projects now, if you wish, so that some administrative

can be completed. Any notes you may wish to send can be
discussed here, and we can help you write the necessary protocols.
I have discussed some suggestions with Dick and he may be of some
help.
I look forward

to seeing

you in

July.

Sincerely yours,
Max

Fink, $4.0.

Professor of Psychiatry

MF:kpt

ﬁrm-"-

rum-Wu

.

-.

u--—

.rvnww-w'"w-'a~r&lt;zuw‘

�</text>
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Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medical School
303 East Chicago Avenue
Chicago, Illinois 60611
Dear John,

Enclosed are two copies of my review of "Drugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.
made me

Thank you

read

it

for the opportunity to review this volume more carefully than I might have otherwise.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

it

�</text>
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                    <text>February 4, 1971
Dr. Richard Brotman
York Medical Coilege
York, New York 10029

New
New

Dear Dick,
As I discussed with your secretary, I have made arranggments
Dr. Stephen Bernstein and a committee from NIMH to use Room 64
on February 18, between 9am and 1 pm.

for

I

trust this is satisfactory.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

�</text>
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wwum-m,

“rm-Wm

February 4, 1971
Dr. John R. Hughes
Northwestern University-McGaw Medical Center
The Medicel_School
303 East Chicago Avenue
Chicago, Illinois 60611

"W'

'

;rurgxwwﬁew

Dear John,

:rv

ﬁre-tart»?

«1"

Enclosed are two copies of my review of "Brugs and Cerebral
Function". There is a need for studies of drug effects on brain
function, and while this volume has some interesting reports, the

overall effect is limited.

I
Nth—5.3

ammunzw,

made me

Thank you

read

it

for the Opportunity to revtew this volume carefully than I might have otherwise.

more

it

Sincerely yours,

_

,

award“

“"1."

vzsr'ww

Fink, “.0.
Professor of Psychiatry

Max

W

‘Y'ur'r

“Th7!"

Mszt

Wmmﬁmtrmrw

‘1

r;

, Au.“ - “Ai‘,i___..._‘.‘m.

,7

,9;

c

,

:M»~

-

:4,

1,;

mums“,

navrvm

m—

�</text>
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                    <text>u

February 5, 1971
Dr. Ernst Rodin

Lafayette Clinic
Detroit, Michigan
Dear Ernst,

I
in the

am

pleased to propose Dr. Jan Volavka, H.D. for membership
EEG Society.

American

in extensive experience in EEG, beginning in
received his training in Prague, London, Munich and New York;
is the author of 37 publications, 33 in electroencephalography. His
interest is in normative and quantitative EEG, and since 1969 he has
been a principal associate in EEG in my laboratory.
1962.

Dr. Volavka has
He

I believe he would be a valuable, contributing
EEG Society.

American

member

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
MF:kt
811C 0

of the

v-wv

mm "am-rm,“

w.'ll-—

�</text>
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                    <text>February 8, 1971
Dr. Fred lagan
Upjohn Company
Kalamazoo, Michigan
Dear Bred,
At the APPA meetings this weekend
speak to Ronald Fieve about rubidium.

I

had the opportunity to
has an IND but the
restrictions for human trial are severe. To date he has increased d
dosages gradually to a dose (he could not recall) which seemed
He

insufficient to alter mood or behavior. He does have extensive
laboratory data, primarily blood, urine and EEG measurements.
These have been summarized in a report to the Aachiveb 06 Genenaz
Rbychlattg, but the report has not yet been accepted for publication.
In addition, he has animal toxicology
studies in progress.
He knows

(3 generations of mice)

of Plotman's public statement but diacounts the

evidence as inadequate. One basis for his interest is a review
of 19th centurj literature in which he noted many claims of therapeutic

benefit.

I was impressed with his enthusiasm and interest. He has a
good reputation, and while the evidence for psychoactivity is slim,
I would like to hear him discuss his work in public. If your interest
is sustained, I am sure he would be pleased to discuss his data.

It is

an

interesting problem.
Sincerely yours.
Pink, M.D.
Professor of Psychiatry

Me:

MF:kt

�</text>
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                    <text>7

February 8, 1971
Mr. E. Marrese

Inmigration Specialist

New

State

York

Employment

Central Immigration Office

68~O9 198th

Corona,

New

Service

Street

York 11368

Dear Mr. Marreae:
Mr. Mark Komloai

will attach electrodes to scalp of subjects;

measure resistance: record brain waves: deliver electronic stimuli;
record responses. He will maintain equipment including, EEG, tape
recorder, oscilloscope and electronic stimuli generator. After each

experiment, he will analyze the data for final analysis.
The

”psychological tests" are electronic stimuli which require

judgements by the subject. The rate and strength of stimulation are
constantly monitored by the psychophysiology technician.

I have no copy of the advertisement in the ﬂow York Times.
appeared September 13, 1970 and was their copy No. 03197, Class 0049,
descriotion ~ Research.

It

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:kt

�</text>
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                    <text>February 9, 1971
Dr. Albert
.—.-.~

,.

ramp

J. Silverman

Professor and Chairman
University Hospital
Neuropsychiatric Institute

Ann Arbor, Michigan 48104

nag-«n

‘v'vn

Dear A1,

l‘ww

I have discussed your letter to Arnie Friedhoff regarding
in the APPA with other members of the Council. The
Assotiation has faced this problem before, and has established
a category of membership; "corresponding member" for this
contingency. Corresponding members are privileged to receive
all communications, attend meetings, participate in committee
functions.

-.

membership

We would be pleased to include you in the membership.
to active status can be made at your request.

Will you reconsider?
«4,

My
awry—mummy”

best regards.
Sincerely yours,

pry,-

.

V

Fink,
Secretary

Max
WNW».

«NW

3!
734'!-

"W"

urJ-‘u-vm—Jr'v

Twmfm.rj-E‘an1-rj.wr

’5».

~

MF:kt

M.D.

Transfer

�</text>
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                    <text>~

v» no.» In. n 15990:»J-rw.‘vl&gt;-ﬂ'v’-

1-

w.

13-

«~st

'

‘

w

'1

3" u

_

m... :'1»_‘r\yum.v-w-r--su|:.'~"'&lt;'.r

«mm-”ware an:

“new”

"“

February 9, 1971
Dr. Ronald Fieve

Psychiatric Institute
722 west 168th Street

New

York,

New

York 10032

Dear Ron,
On behalf of Milt Greenblatt and the Council
of the APPA we
wish to express our gratitude for the fine work you did on behalf
of the APPA for our annual meeting.

I believe the publicity was most useful in increasing the
attendance of this year's meeting.
Many

thanks.
Sincerely yours,
Pink,
Secretary

Mex

NF:kt

cc: Dr. Greenblatt

M.D.

.v-vmv-

�</text>
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                    <text>P1»;- k ~v’.&gt;.-vv

.

.

i
5‘

I1

It

su.

E
F
,

;

February 9, 1971
Dr. Donald Klein

Hillside Hospital
P. O. Box 38

Glen Oaks, New York
Dear Don,

of the APPA
behalf of Milt Greenblatt and the Council
work you did on
we wish to express our gratitude for the fine
annual
meeting.
behalfoof the APPA for our
The arrangements were excellent and I hope that the Association
will renew the contract with the Roosevelt.
On

Hany

thanks.
Sincerely yours,

Secretary
MF:kt

�</text>
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                    <text>2
w—v-»&lt;-,.
rum—aw

1

V;:'.r\ 4:- , v 1w.

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_

v

any
e

x

,

_..

,.

,._'21‘r.-m

w rm.»
wmrxam-m
-

-

-a

~;/.«.m.«,~:-r-.&lt;.rzan.ar-w.;:wmv:wv-w;--.«~mnr

v

v-1

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Arr» m- wvyv "

:~ ‘V'n‘a'l-

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1..

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"as,“

February 9, 1971

A

~..

~

.Iznaryw—vm-v-

mum-,2

Dr. Allen P. Berger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen,

"nw'mm,

I’vnu-Fyew'VK'

~

WrT-msawmnn-mwnq

Enclosed are four additional "incomplete" records of
patients in the thiothixene~th10ridazine—placebostudy.
Please make whatever copies you wish and return as you
did in the earlier data.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

-r

.

..

H

vw-“v

.:

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~

-x

,

_.

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�</text>
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                  <elementText elementTextId="106156">
                    <text>{

lawn."

..

.,w...z-

m a. maxim...” ., ”,“mﬂuy"WW...”W.“magi... \1A'glmWr,

V,

«QM»

1.4g“;

,-'

-

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7..

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v.

n ...

ammwwm

1..."--.

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W.—

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w.

w,

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W".—

February 9, 1971
Dr. Edward Gordon

Director-Methadone Treatment Program
Community Mental Health Board

County Office Building
White Plains, New York 10601
Dear Ed,
Thank you

quite complete

clinics.

for the procedural manual for methadone.
and I can understand why it is useful in

It is

establishing

I would be pleased to have you visit our program at Metropolitan
Hospital. Half our patients receive methadone or Kmalpha—acetylmethadol,
and half cyclazocine. The latter group is our more interesting study
_group, for we have the anticipation that this method may allow an orderly
cessation to the addiction, particularly if a long-acting delivery form
could be developed.
Again,

my

thanks for the manual.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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    <itemType itemTypeId="1">
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              <elementText elementTextId="47532">
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            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="47533">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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        <name>Correspondence</name>
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  <item itemId="4752" public="1" featured="0">
    <fileContainer>
      <file fileId="2794">
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                  <elementText elementTextId="103420">
                    <text>Maw-n

»

I

mr'r

‘

.«w

.

w."

xmhwwwrhr'» ‘WWW'IMATWW.’

1,“

~rww"\-&lt; www.msv- —...«—v... -.‘.-.

m.“—

w w.”

..

nun-w, ,-

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..

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February 9, 1971

&lt;

.17..

.
\e
s

V,..,_ﬂw..w...

Dr. David Metcalf

University of Colorado Medical Center
4200 East 9th Avenue
Denver 20, Colorado

.,v,-,W,w-,,.

'5"

Man-m

yaw-re.“

&lt;....

umiyv-mwtrn,

Dear Dave,

In 1965, NIMH supported a collaborative study of schizophrenic
patients treated with placebo, high dose (1600 mg/day) and low dose
(400 mg/day) chlorpromazine for 6 months. In one study, by
H. C. B. Denber at Manhattan State Hospital, EEG records were collected
pre-drug and monthly, from 2 lead pairs (RQ~RT ear, RF-RO). The records
were accorded on magnetic tape and the tapes were analyzed in 1966 in
St. Louis on the IBM 1710 data analysis system. Sample size was 30
seconds; 320 samples per second; without prefiltering; period analysis
for baseline cross and first derivative.
Of 120

.r‘vg’ﬁwmurww

EEG

patients,

The sampling

we

had good records

process

was random,

characteristics before treatment

in

72

subjects.

for there were no differences in
the three treatment groups.

among

,r—a'vmzr

.m—r

m1"

wwrr‘

related changes for each variable using non—
For both lead pairs, dose and drug related
changes were found in an increase in theta activity and a decrease in
frequencies above 40 cps. Variability of frequencies also decreased.
We

-.
.v
Ar

wr-w-ezr-srv—r-r

-

F'rrm.

:*
v.1

emu-m

vmv-nwu'l'ﬂ

.«
w-

«A

«w

vmwxwrwANW-u.‘

statistics.

In an earlier study,

Mme

u

examined the drug

parametric

we

observed a similar

in schizophrenic patients treated with
6

weeks (Fink, 1961).

profile of

EEG

1200 mg chlorpromazine

change

for

These two studies indicate that changes in the EEG after
chlorpromazine are drug specific, dose related in degree of change,
and persist for periods up to 6 months of continuous treatments.

�V“,

_,
.,

Dr. D. Metcalf

—2~

February 9, 1971

,nywwm.

It is clear

similar studies, that the EEG
changes with psychoactive drugs are not "side~effects" or “abnormalities"
but direct effects of the drugs, reflecting the central processes which
from

these,

and many

they are supposed to effect.
We

failed to

make

direct correlations between the

EEG

change and

behavioral improvement with the two doses of chlorpromazine in these
patients, although there was a difference of drug gs; placebo. The
differences between drugs were small,.and while significant in amount,
the behavior changes were small. For a detailed discussion of the
behavior changes, see Prien and Cole (Arch. gen. Psychiat., lg; 482-695,
1968).

.r'v"

xv

uwxmm‘iﬁrww‘WW-swu

”nan-mgr”

"neuter.

If these comments are useful, they may be quoted either as "personal
communication" or as presented at the Society for Biological Psychiatry,
May 1967. Enclosed are abstracts and exhibits of the presentation.

It was a pleasure to discuss these interesting problems. I met
with Turan Itil in Aspen, and told him of your interest in the
schizophrenia study in Copenhagen. He is the principal investigator
and should write to you when he sets up the project.

.1“,

My

,

”nan-r

r7

best regards.
Sincerely yours,

yuan.

rag-w”

'3"
.~

u

Fink, M.D.
Professor of Psychiatry

Max

y.v/;,1-Iv,'-‘.'_‘y.4u

"Wt-w

.m-u-g:

,mrgﬂswl.

Janus-'1

MF:kt

�</text>
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                    <text>wwww‘rr-wx‘

1‘

w,- um.

.z-w-

vvvwm.mw: ‘m‘

.

'

&gt;—

,

Wmv'm~om'-rummwr 7.72:»

--vv

February 9, 1971
Dr. Fritz A. Freyhan
153 West 11th Street
New York, New York 10011
Dear

Fritz,
I

am

most

gratified

in the Council of the
for your confidence.

me

by the support chat you have given

APPA.

I wish to express

my

thanks

I would be honored to join the editorial board of
Compnehanaiue Paychiaxay and shall do my best to support
the traditions of the journal.
My

best regards.
Sincerely yours,
Fink,
Secretary

Max

MF:kt

M.D.

�</text>
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                    <text>'-."='w-1V)‘1¢1Wb"vﬁTtym'mzn

m

vw

sf. -.'-. r». way»

»

,v—n-wu

VVL~Ww-rv-r—vl-~“3I—me a-yrmnn

wt“...ru-qwﬂw

mp...“

“‘Wuwv—lw...—-;. w.¢,..:..at... , “-..._ t ”.7,

vw-zmwmnwwmru-sn

w

'
v

.

y

t
..v

.

.,,

,
W...

.
V

Rwy

.w

February 10 , 1971

7.wa

..._

Dr. Robert Petersen
National Institute of Mental Health
5454 Wisconsin
Chevy Chase, Maryland 20015

Dear Bob,

I spoke to Dr. Allen Isin of Bulfalo at length today, and
found him knowledgeable about polymers, release rates, hydrogels,
etc. He offered to assist us in determining the release rates of
out antagonists in his polymers.
I

was impressed and we

agreed:

n.

(1)

‘

"Farr-4's

.

some
.
nam‘

He

I would review these with the chemists and send him
cyclazocine and naloxone;
We

their consultant.
in

literature about his processes;

(2)

(3)

'a1-2'1'mwzr

would send us some

Many

a long
My

(out chemists) would call Dr. Kenneth O’Driscoll,

thanks for the

referral. I

acting antagonist.

hope we can get some progress

best.

7w"w:ww:;vtﬁww'mj.~wﬁ'i=u

Sincerely yours,
u'gzvmmm

Fink, M.D.
Professor of Psychiatry

Max
,,,,

V"

A:

MF:kt

cc:

A. M. Freedman, M.D.

.

,,.,..,..

_. t.

m ..

�</text>
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                    <text>February 10, 1971
Mrs. Carol Lewin, President

Metropolitan EEG Society
United Hospital
Boston Post Rd.
Port Chester, New York
Dear Mrs. Lewin:

not have a supply of the EEG classification paper
sufficient to make the many copies you requested available.
I am enclosing some copies in the hape that they can be
duplicated where they are most wanted.

I

do

I would be pleased to be a speaker at one of the monthly
meetings, and suggest you call to set up a date.

I

would also commend my associate, Dr. Jan Volavkc to you,
as a speaker. He has an extensive experience and could discuss
a variety of subjects with much merit (369—7900, Ext. 247).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF1kt

enc .

�</text>
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                    <text>February 10, 1971

Peter

M.

Levine

2520 Monroe

New

Street, Apt.

C

Orleans, Louisiana 70118

Dear Mr. Levine:
Thank you

for your inquiry about

a summer fellowship.
not have the opportunity to support a
fellowahip this year.

I regret that I

do

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>§“v‘vmwmrv

‘

'v'rav'v u

To:

Dr. Fanaterhaim

FROM:

Dr.

Max

DATE:

February 10, 1971

Fink

Freshman Lectures 1971

SUBJECT:

I will be pleased to discuss Brain Function and Behavior
with the Freshman medical students on May 10 and May 17, from
11 a.m. to 12:50 p.m. I plan to describe the following:
1.

Brain measures,

EEG;

vigilance, trauma

hallucinogens, opiates and
alcohol; clues to a therapy of addiction

2.

Drugs and behavior:

3.

Drugs and Behavior:

"an"

effect of maturation, sleep,

antipsychotic drugs;

a

rational therapy of abnormal behavior.
4. Convulsions and Behavior: ECT and a “rational"
therapy of depression.

The

For references, I would suggest they read: Grey~Waltor,
Living Brain, N.Y., w. W. Norton, 1953:
Fink:

2;

EEG and Human Psychopharmacology. Ann. REY' Pharmac01.,
241~258, 1969.

Fink:

Cholinergic aspects of convulsive therapy.

142: 475-484, 1966.

If

you wish more
Thank you

MF:kt

citations,

1

will

for the opportunity.

J. Nerv.

be glad to supply them.

‘

Ment. 018.,

�</text>
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                    <text>.m-an

»

-

&lt;1“

—,.

leﬂrpﬂymm-‘Ww

T

February 10, 1971
-

""371"

imv‘vr-rm’ml‘

g
gurkn’

Dr. Jerome Levine

Psychopharmacology Research Branch

National Institute of Mental Health
5454
Wisconsin

Chevy Chase, Maryland 20015

Dear

Jerry,

..—r

RE:

MH~13358~05

,-,~—.

&lt;.
’"'

ﬁi'n'rmvr‘wwmwﬂ'!‘

In the event that MH—13358~05 is funded effective
1,
at an annual rate of $60,000, I would request the June
following
reallocations of direct costs to maximize the use of our
facility.
Personnel
$39,700
1971,

Consultant
500
Supplies (incl. electronics)5,800
Travel
2,000
Volunteer fees
6,300

Y-«vac

rW'erv-wwz‘

Other

Publications

l"71"W“"’

IBM

.w

t-‘r

pm.

600

6,000

1800 Maintenance
and Insurance
5400

_,5,ut

Many

thanks.
Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

MF:kt

�</text>
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                    <text>February 11, 1971
Dr. Margaret

J. Giannini

Director, Mental Retardation Center
1249 Fifth Avenue

New

York, New York 10029

Dear Dr. Giannini:
The recent announcement of the N.Y.M.C. Seminar on Mental
Retardation in conjunction with the University of Athens interests
me. It is probable that some of us may be in Athens in March at
the time of the meetings. May we have a copy of the preliminary
program when it is available?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>February 11, 1971

Ir.

Richard Brezinski
Convention Manager
Arizona Biltmore Hotel
Phoenix, Arizona
Dear Mr. Brezinski:

are interested in holding our meeting at the Biltmore,
but the planning group will be unable to make a final reonmmendation
until late this spring. In the event the decision is affirmative,
We

I

will call your office.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

Mszt

�</text>
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                  <elementText elementTextId="106148">
                    <text>w-u‘mm‘w

w-..

February 11, 1971
Mr. Timothy E.
Box 1459

Quill,

Amherst College

Amherst, hassachusetts 01002
Dear Mr.

Quill:

available
for this summer.
are planning a series of experiments, however,
in which volunteer males are asked to take various psychoactive
drugs, either on dingle dose or daily doses for 3 weeks. We are
interested in recording changes in behavior, brain waves and memory.
Volunteers are paid by the project.
Regrettably

If

we

We

you may wish
Irwin (212 - 369-7900,

do not have summer fellowships

to volunteer, I suggest
ext. 249) in late May.

you

call

Mr.

Sincerely yours,
Fink, M.U.
Professor of Psychiatry

Max

Mszt

Peter

�</text>
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                    <text>February
Dr. Ralph

W.

ll,

1971

Richter

Director, Neurology Department

Harlem Hospital Center
135th Street and Lenox Avenue
New York, New York 10037

Dear Dr. Richter:

principal reports from this laboratory on the subject
of "Neurophysiology of Opiate Addiction" are enclosed. These will
provide the basis for the presentations.
I look forward to participating in the AAN didactic sessions on
April 28 at the New York Hilton. While it may be too late to suggest
a change in the program, you may be ill advised in inviting a presentation
by Dr. J. Benson-Gerber, whose hostility to biological approaches is so
will known, as to lead to a degeneration of the symposium section of
The

the meeting.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>February 11, 1971

Editio Cantor

KG

796 Aulendorﬁ
Wﬁrttenburg, West Germany

Gentlemen:

Please establish a subscription to Aazneimitte£6onbchung,
effective January 1, 1971, addressed to:
Max

39

Fink,

M.D.

Arleigh

Great Neck,
Payment

Road
New

s

York 11021

will follow billing in dollars.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

_A

Ahmmn.g.$_

(x

�</text>
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                    <text>-n.-

February 11, 1971
Mr.
7

Charles Chidester

Quaker Lane

Enfield, Connecticut
Dear Chuck,

vzmm

MW

‘gn‘/W.W'"VWDHIW'JM'1"

My associates returned from your laboratories pleased that
the equipment seemed to be in order. As part of their enthusiasm,
and in conjunction with some improvements in the ways we are
recording EEG records here, they have written a set of guidelines
which may be helpful. I would appreciate your reading these with
the equipment at hand and checking the sequence of procedures.

UR-7007

Dr. East

visited yesterday

in the prison

and

and

is proposing

this will probably

be our

a study

first

of

study.

Speak to you soon.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt
cc:

A. P.

Berger,

M.D.

P.S. Separately Mr. Pavel is sending you the cables he promised
for the oscilloscoPe.

�</text>
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                    <text>February 11, 1971
Dr. David R. Metcalf

University of Colorado Medical Center
4200 East Ninth Syenue

Denver, Colorado 80220
Dear Dave,

Enclosed is an abstract for your consideration for the
1971 Annual Meeting of the American_EEG Society. I am not

confident that this application of quantitative EEG is sufficiently
"basic" to interest the members, but it is a reflection of the
EEG.
progress made in the quantification of the
Perhaps a workshOp on present applications of quantitative
EEG may

be useful.

It

was fun

in Aspen.
Sincerely yours,
Fink, E’ioDo
Professor of Psychiatry

MEX

Mszt

�</text>
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                    <text>February 17, 1971
A. Hargreaves, Ph.D.
The Langley Porter Neuropsychiatric
401 Parnassus Avenue

Dr.

Wm.

San Francisco,
Dear

California

Institute

94122

Bill,

Stanley, Rhea Dornbush, Jan Volavka, Richard Abrams and I have read
and discussed your report at length. It is an interesting suggestion,
that the memory and EEG effects may require hours to "mature". In one
group of patients we did try to assess memory changes at 3 hours postseizure but the study was incomplete, and we are unable to contribute
to the hypothesis from these data.
Our recent EEG data does not allow a test of the suggestion. We are
writing the protocol for a new study, however, and if we are able, will
include some serial EEG recordings to try to answer the question.
Thanks again

for the opportunity to read this report.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>February 18, 1971
~

i

The Reverend Phylemon Titus
3991

Fourteenth

Avenue

Detroit, Michigan
Dear Reverend

‘

i

48208

Titus:

Your kind offer of the Opportunity to establish a treatment
unit at the Fourteenth Avenue Methodist Church in Detroit is most
kind and reaponsive to our announcement.

is a non-profit fund raising group hoping to support
medical research, such as we outlined. At present, we are not
in need of either patients or a place to work, but need the funds
necessary to stimulate the research scientists to make the special
efforts necessary to make the narcotic antagonists freely available.
FADA

I thank you

for your

letter to the leaders of

most kind

$ADA.

offer,'and have forwarded your

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
cc:

FADA

�</text>
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w.—-- -—-- )1"

uswow-r w
.

»

w-im

.

v

.t

_

M

n .t

,_.

t .. .

.

.

.~4

r‘ 'W‘IV—r up
.,

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1—7.V—V.—.-v
n

W w,,,,....,.,.

.,.hr,.~.
.

.

v“...

.. .

.‘

,

. w.»

.7
,

~

w:

,

mast-o‘—

February 19, 1971
Mr. Robert

Cortese

Paxton Street
Paterson 3, New Jersey

.241

‘Dear Mr.

Cortese:

Unfortunately, we do not have the material to treat patients
outside Metropolitan Hospital in New York City. The treatment is
on methadone
still experimental. I would suggest you continue
until a narcotic antagonist is perfected and commercially available.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mfzkt

�</text>
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                    <text>»

«

47.1w.

ﬁrmu’rr‘u',

&lt;——,~

brawn—“W

.

ﬁu-r-z

M's--

.-_‘..&lt;r,-—

February 19, 1971
Mr.

J.

Bondoux

Manager, Systems DeveloPment

Biochemical Procedures
12020 Chandiey Blvd.
North Holywood, California 91607
Dear Mr. Bondoux:

their

you

Both cyclazocine and naloxone are experimental drugs. For
chemistry, availability outside our laboratories, I suggest

write the manufacturer:
Endo
1000

Laboratories
Stewart Ave.

Garden

City,

(naloxone)

New York

Sterling-WinthroP Research

Institute

Rensselaer,

(cyclazocine)

New York

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>n"-

'

1
5
v
-

'
-:z-

«Hrs—x

-

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology

Dartmouth Medical School
‘Hanover, New Hampshire 03755
Dear Dick,

write a useful review of EEG and drugs is probably a
good idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
To

Review of Pharmacology.

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
other processes with which association-dissociation theory has
to deal.
To

In sum, the idea may be interesting but I do not see a
central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CKS
changes induced by drugs” is grand and unfocussed at this time,
and probably very difficult to focus.

It

in ASpen and the memories sustain me through the
of days in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>February 19, 1971

4

0f

you go send an the

articlc

from Mexico City.

«in; to find the programs and so

tried a press

'ariety in the reports is intartsting.

~'es are continuing, although slowly. 'We have
father
:9 square to Motroyolitan and so see yourwork
I
and
the
hope
$g.no of your agpointnant,

Sincsroly yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>February 19, 1971
Mr. Robert
241 Paxton

Paterson 3,

Cortese

Street
New

Jersey

Dear Mr. Cortese:

Unfortunately, we do not have the material to treat patients
outside Metropolitan Hospital in New York City. The treatment is
on methadone
still experimental. I would suggest you continue
and
commercially available.
until a narcotic antagonist is perfected
Sincerely yours,
Pink, “.0.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>February 19, 1971
Mr. Demetri P. Kenellakos

Stanford Research Institute
Park, California 94025

Menlo

Dear Mr. Kanellakos,
Thank you for your survey of the literature on ”Voluntary
differences
It is clearbethat
Improvement of Individual Performance".
but
defined
TM
can
and
other
states
between the measures during
defined.
be
to
their regularity and significance are yet
I found your review most
Many

thanks.

If

helpful.

you can, give

my

regards to

Lee

Otis.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>w-

-Fr-uu-v...u

new."

u.

February 19, 1971
Dr. Ralph D.

Miller

Research Director

Commission of Inqqiry into the
Non-Medical Use of Drugs

Fuller Building
75 Albert Street

Ottawa, Canada
Dear Ralph,

"If wishes were horses, beggars would ride."
It is easy to bring you up to date. With regard to Athens,

'1
v-

data in volunteers smoking 1.5 gms,
0.5 gm or 0.0
variety 12.5, 7.5, 0.0 THC) in 2 minutes.
Found an EEG effect with rapid onset (less than 2 minutes) and waning by
8-10 minutes. Tried some samples of THC concentrate in a short cigarette
(30 min.) in 30 seconds. Great EEG changes! To do study needed slightly
larger supply of concentrate than I had on hand. Call NIMH in November.
Committees met, powers-that-be considered and decided that concentrate for
animals only, not for man. Raised a bit of a storm, and after 2 1/2 months,
was told would get supply last week. Still waiting.
In

YEWFIWJME’T

«a
N

'F
‘I'JY-

‘19

‘Y

'51"

in

("lewm‘

W53.

"ﬁ'iﬂfatm

‘

New

Was

Waiting.
17.4EOIVP."'I"WA‘WWW"

York,

we

if

we

analyzed our

gm MJ (NIMH

asked

would

EEG

8

like to see Jamaican group. Said “yes”.

So, come visit. Will be glad to show you our data.
studies will be on-going when you visit.

raw

Hope you do

.4
s~

things better in Canada.

5'-

Sincerely yours,

wwrs

X".¥.-‘M.

”.mpwmw—mvv

Fink, M.D.
Professor of Psychiatry

Max
‘l
strut-M

Mszt
WMV'VOG-ﬁ

may

~

‘=

=W71HW

It”?

we

were able to re-negotiate the conditions of our contract between September
and January; wrote to Athens to begin the study in March; and await a
reply. [Negotiation hang-ups usual administrative in Washington.]

Perhaps the

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                    <text>.

w.

.g._.,—._—Y,,,,.u-

m.”

a“!

raw-ma.

-&gt;w~:~'—‘1'J\WT..M-.W*‘~.W

n,

,

,_

:n,

W‘uv'

wwwiw

a»,

7......"

n

February 19, 1971

.0.

noun».

army-7:.

Dr. Walter Essman

Department of Psychology
Queen's College

Flushing,

New

York

Dear Walt,

seminars in Psychiatry, a new quarterly publication edited
by Milton Greenblatt and Ernest Hartmann, has suggested that the
to Recent Progress in
first issue of 1972 (February) be devoted
have
am
accepted the invitation
I
Convulsive Therapy.
pleased you
Seizures". The notes in
of
"Biochemistry
on
to contribute the report

the outline are suggestions, and you are free to expand on the topic

as you wish.

The volume

200-300

is usually

typescript pages.

120*160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

meet the publishers deadline, can you make a
by the end of June?
To

draft available

a policy of the seminars to re~issue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

It is
I

hope you can

join us.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

�</text>
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                    <text>w.

.w

w-~r

v

WWF‘WW

emu-W

Mfr?

February 19, 1971
Dr. Richard H. Rech

Associate Professor of Pharmacology
Dartmouth Medical School
New Hampshire 03755

Hanover,

Dear Dick,

write a useful review of EEG and drugs is probably a
idea, although I did my best in 1967-68 in the review I
prepared for the Efren book and for Henry Elliott's Annual
good

Review of Pharmacology,

rewrite the dissociation-association hypothesis seems
pointless, since the material of 1966 is published and not yet
superseded. To report the material presented in Aspen is less
useful, since we did not have either a consensus nor a clear
issue about which sufficient data were available. Killam, John,
Adey and others are making connections between the AER and correct
and incorrect decisions - some distance from mood, thought and
To

other processes with which association—dissociation theory has
to deal.
In sum, the idea

WW‘IM'WWWN'Lty

unI-x'w

-.:.ur"N'

a—nwma-

'nvtr‘rlwwaw-mwamm‘J.

To

may

be

interesting but

I do not see a

central issue that is needed to spark a viable volume. The
"fundamental relationships between the EEG and functional CNS
changes induced by drugs" is grand and unfocussed at this time,
and probably very difficult to focus.

It

in

Aspen and the memories sustain me through the
in the most filthy of cities. Don't they
need professors in ecologically clean Dartmouth?
was fun

most dreary

of

days

Sincerely yours,
an

p:.-~n.-rzuv.c~

Max

.u—wq

w".

'

-r'x:~mnu1«..

":1

.

Fink, M.D.

Professor of Psychiatry

r,

MF:kt

�</text>
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                    <text>February 19, 1971
Dra. Rhea Dornbush and
New
New

Stanley Feldsteiu

York Medical College
York, New York

Dear Rhea and

Stanley,
seminars in Psychiatry, a

new

quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. 1 am pleased you have accepted the invitation
to contribute the report on "Memory and ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

To meet the publishers deadline, can
you make a
by the end of June?

draft available

It is a policy of the seminars to re—issue reports of general
interest in hard cover. If we are successful (and
I
the
volume to have widespread interest), the volume shouldanticipate
then be
cited both as a periodical and as a book. assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Max

Pink, 5.9.

Professor of Psychiatry

Mszt

�</text>
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Dra. Rhea Dornbush and
New
New

Stanley Feldsteiu

York Medical College
York, New York

Dear Rhea and

Stanley,
seminars in Psychiatry, a

new

quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. 1 am pleased you have accepted the invitation
to contribute the report on "Memory and ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

To meet the publishers deadline, can
you make a
by the end of June?

draft available

It is a policy of the seminars to re—issue reports of general
interest in hard cover. If we are successful (and
I
the
volume to have widespread interest), the volume shouldanticipate
then be
cited both as a periodical and as a book. assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Max

Pink, 5.9.

Professor of Psychiatry

Mszt

�</text>
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                    <text>February 19, 1971
Dr. Richard Abrams
York Medical College
York, New York

New
New

Dear Dick,

seminars in Psychiatry, a new quarterly publication edited

by Milton Greenblatt and Ernest Hertmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I an pleasedyyou have accepted the invitation
to contribute the report on "Clinical Results: ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.

is usually
typescript pages.

The volume

200~300

120«160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including
To meet the publishers
by the and of June?

citations).

deadline, can

'

you make a

draft available

It is a policy of the Seminars to re~issue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.
I

hope you can

join us.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

.

Mvw

5)."—

�</text>
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                    <text>February 19, 1971
Dr. Joyce Small

Carter Hospital
Indianapolis, Indiana

LaRue

,u
..

NLJq-yInLL-I

L"¢I~{"

"Jl‘

«aw-:12.

-,:r
\r
.1

“ygmﬁ'ﬂ”

~'E‘1-".G"I‘_'!"‘7"

‘

‘qua-uey

an?!

Dear Joyce,

Sbminars in Psychiatry, a new quarterly publication edited
Greenblatt and Ernest Hartmann, has suggested that the
Milton
by
be devoted to Recent Progress in
first issue of 1972 (February)
am
I
pleased
you have accepted the invitation
Convulsive Therapy.
Results" Indoklon (vs. KCT)".
"Clinical
on
the
report
to contribute

notes in the outline are suggestions, and you are free to expand
on the topic as you wish.
The volume is usually 120-160 typeset pages, equivalent to
200—300 typescript pages. Your report should range from 25 to 30
double spaced pages (including citations).

The

To meet

the publishers deadline, can you

by the end of June?

make a

draft available

I.
w
-,

y
a;

'Kauc'qa

-'
o;

“L!“

.

a policy of the Shminars to rewissue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

It is

"jﬁ"?1"!‘l'_

"
r?

I

hope you can

join us.
Sincerely yours,

u‘f'A‘szﬂ

:'
.

‘-

'rﬁawumz'

Fink, ELI).
Professor of Psychiatry

Max
FCWJ.‘

Mime-:5}.

"Ref:

rmmmlwaw'

in?"

7W}
laws

MF:kt

�</text>
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                    <text>February 19, 1971
Dr.

Ferris Pitts

Washington University School of Mbdicine
660 South Kingshighway

St. Louis. Missouri
Dear Dr.

mm

a
~:L

.w.

57.

“may

“.1.

,a‘
(

WWI-V

Wnrva"

Pitts:

Seminars in Psychiatry, 3 new quarterly publication edited
by Milton Greenblatt and Ernest Hartmanu, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I am pleased you have accepted the invitation
to contribute the report on "Medical Aspects of BCT”. The notes in

the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200~3OO

is usually

typescript pages.

120~160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced page: (including

7

($11?"ng

63110

To meet

citations).

the publishers deadline, can you

by the end of June?

make a

draft available

"m"

maumnm.

47

m

,5.

an!)

W

It is

a policy of the seminars to re~iesue reports of general
interest in hard cover. If we are successful (and I anticipate the
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.

'01

I

x...

V.

;L-v

hope you can

join us.
Sincerely yours,

nz—w-m-wwm

I/rJ

en;

"r“:

Max

mm.

.IWV.‘7

‘HT’E'T

a
U-Z'

a.

WWW/1’

‘34

‘:

«um-"c

--

.7“!

"my"

Fink, M.D.

Professor of Psychiatry

an'

MF:kt

�</text>
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                    <text>I

.

a
.

...-.my..~wvwvnw,....

February 19, 1971

.r-en—«mqu...._.-:W—«rm».

Dr. Jan VolaVka
York medical College
York, New York

How
New

Dear Voita,
mwmpnmwwwnww

n-w-wrwv

_--m

.

seminars in Psychiatry, a new quarterly publication edited

by Milton Greenblatt and Ernest Hartmann, has suggested that the
first issue of 1972 (February) be devoted to Recent Progress in
Convulsive Therapy. I am pleased you have accepted the invitation
to contribute the report on "Neurophysiology of ECT". The notes in
the outline are suggestions, and you are free to expand on the topic
as you wish.
The volume

200-300

is usually

typescript pages.

120-160 typeset pages, equivalent to
Your report should range from 25 to 30

double spaced pages (including

citations).

meet the publishers deadline, can you make a
by the end of June?
To

.u
1‘

.A

~vwa-wm-wvvrv-u

draft available

It is a policy of the seminars to re—issue reports of general
the
interest in hard cover. If we are successful (and I anticipate
volume to have widespread interest), the volume should then be
cited both as a periodical and as a book, assuring a wide distribution.
I

ammo-awn-

hope you can

join us.
Sincerely yours,

2‘:

u

u-wzw-

.

Max

ﬁrearm

-»'.m.

'4‘

”E‘N'1‘1

a...

.m—y-

.r-W-um

w‘

9

-‘J‘W‘f‘

Fink, M.D.

Professor of Psychiatry

.;

MFtkt

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                    <text>. "*0...”

V.“

..

,_..

.w

H.

«mm ‘.,_,;v...-._,w.

.--.,

a.

.5

..

v.

-...,,.,-,

,

.

.,

.,..,,_.»u-nwn.y....v.sw..,wv.“.. :1v:""”'v~“t,"u -.. .-.

y

w .

,

=

n

.v _-....... 3.-....

.c.

«www.mn‘mV. .1. we
.

a ..._.,

.

”r,

February 23, 1971
Dr. Walter Essman

Queen's College

Flushing,

New

York

Dear Walt,

sw'associates and I very much enjoyed your visit, and
forward to our collaboration in studies of the BCT process.

we

look

To confirm our understanding, we will re-write the protocol of
our next study to allow the collection and assay of CSF before and at
various times after seizures. We will be responsible for the behavioral,
memory and EEG data, trusting to use your facilities for the chemical

assays.

practicable, you or one of your associates, will
technician who will be appointed to our staff. I would
appreciate your recommending a salary range and working hours; and
we will establish the salary and perquisites.
As

soon as

recommend a

The Association is a non—profit corporation which supports various
research efforts in mental health and for the past few years has assisted
I am pleased that the Association will
me in supporting this ECT program.
appoint you as Consultant in Biochemistry, for an indefinite term at an
annual salary to be negotiated.

While our funds for equipment are limited, we are more liberal in
”supplies” and "personnel” and should be alle to honor such reimbursement
requests as may be agreed upon.
We

look forward to working together. In the event the data is
it has been our practice to defer the presentation to the

publishable,

scientists most intimately responsible for the data collection. I would
results will warrant publication and further study, and in the

hope the

processing of support applications, I would urge the use of the agency
of IAPR.
I believe

association, as
My

this is the essence of our discussion.

do

my

co-workers.

best regards.
Sincerely yours,
Fink, M.D.
Executive Director
Max

Mszt

I welcome

this

�</text>
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                    <text>in?”

n.—

sz-aw

-

--

*lW-mvnrv‘ ’i-‘orarw~y.-w—._..mwv~w
Isa-um)...
v

,

W... IAﬁmyrxnn’m'wm'ndwﬁ‘wl-mv4wV1-‘V‘ﬁ

NVTWv'n-l'wu‘nr'vwm'vvrnw.

v m,w

-mww-m-«aur‘w—mqwngnm "w?" r—u-w

February 22, 1971
Dr. William Martin

National Institute of Mental Health
Lexington, Kentucky
Dear
v,

”.mpnwwma...

,1."

,..7..,.,.

Bill,

Art Zake reported that the data on EN 1639 is as interesting
as you hinted last fall. Unfortunately, illness prevented my
attending the meeting, and I am writing to ask if you can make a
copy of the report available to me.
Hwy thanks.

‘uv‘ll

Sincere ly yours,

.

.

“Al-runtrw'mwwwrr-vw.

arm

.......,_.,&lt;

wwmm~mmwmwu

Max

Fink,

M.D.

Professor of Psychiatry
MP:kt

me 7-:

.

-

,-.

�</text>
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7...

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February 23, 1971
Mr. Paul Argeros

13945 N.E. 10th Avenue
North Miami, Florida 53161
my

Dear Mr. Argeros:

It

was

kind of you to write about our research program.

still in experimental trial and are not
available outside our institution. For the meanwhile, we suggest
you continue with methadone. We are confident that as soon as our
treatments are approved for general use, they will be publicly
available in your community.
The drugs are

Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
«ran-n

Err-

,

MP:kt

_.

.,

,

_

�</text>
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February 23, 1971
Dr. E. F. Domino
Department of Pharmacology

Medical Science Building
University of Michigan Medical School

M6322

The
Ann

Arbor, Michigan 48104

Dear Ed,
We

were pleased

to receive your review of the biochemical

possibilities in CSF studies in ECT. It may be obstinacy, but the
primary problem is acetylcholine, not the cholinesterases. That the
leech muscle is insensitive is a severe barrier, and these studies
will then have to wait the refinement of methods. The studies and
theories of epinephrine, norepinephrine and serotonin in psychiatry
received their heavensent thrust from the chemical description of
means of measurement, not from a theoretic model. Hopefully, the
same will follow when a new method fer ACH is deveIOped.
Many

thanks for your frank discussion.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
A

A

vale...

n

.W

�</text>
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—‘v1w—W.

awn-w"

Mr. Paul Argeros
13945 N.E. 10th Avenue

North Miami, Florida 33161
Dear Mr. Argeros:

It

was

kind of you to write about our research program.

The drugs are still in experimental trial and are not
available outside our institution. For the meanwhile, we suggest
you continue with methadone. We are confident that as soon as our
treatments are approved for general use, they will be publicly
available in your community.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MFtkt

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.,

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.

..

.

.

.__ -W. . “F‘WNV
_

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cm

ﬂ W._‘.

February 23, 1971
Dr. E. F. Domino
Department of Pharmacology

Medical Science Building
University of Michigan Medical School

M6322

The
Ann

Arbor, Michigan 48104

Dear Ed,
.m..—qrw&lt;w

to receive your review of the biochemical
studies in ECT. It may be obstinacy, but the
possibilities in
primary problem is acetylcholine, not the cholinesterases. That the
leech muscle is insensitive is a severe barrier, and these studies
will then have to wait the refinement of methods. The studies and
theories of epinephrine, norepinephrine and serotonin in psychiatry
received their heavensent thrust from the chemical description of
means of measurement, not from a theoretic model. Hepefully, the
same will follow when a new method for ACH is develoPed.
We

v-cwnv—r,

l-—

r

were pleased
CSF

Many

"Nu...

thanks for your frank discussion.

Sincerely yours,

mmvynpwy

-

V-mw'rwa

a

Fink, H.D.
Professor of Psychiatry

Max

In:

.

7m-ml'vmrrw

:mstn'qu

vm“-m~wwwr

r
1::
aw:

"we

Mszt

�</text>
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                    <text>February 24, 1971
Mr. Nathan
NAPAN

Strauss

250 West 57th

New

York.

New

III,

President

Street

York 10019

Dear Hr. Straue:

It

was kind of you to send me the January

NAPAN

bulletin.

extent of the activities of the association is interesting
and you are to be commended for your interest in the difficult
field of addiction.

The

I noted with some nostalgia that Arthur Fatt is a member
of your board. I met Mr. Fatt years ago when I was Research
Director at Hillside and we were interested in funding a research
building. I am sure he will recall the meetings with Israel Strauss
and Herbert Beskind.
Perhaps this is an opportunity to suggest that the next
methadone conference may contribute even more if other bidlogical
modalities were discussed, particularly in answer to the question,
"After methadone, what next?"
Thank you again

for your interest in the

Academy meeting.

Sincerely yours,
Pink, 3.9.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>February 25, 1971
Dr. Joseph Zubin
722 West 168th Street
New York, New York 10032
Dear Joe,

enclosed letter from Dan Blain should be answered,
and I can think of one—one better qualified than you.
Would you answer this request?
and

The

A1

Many

thanks.
Sincerely yours,
Max

Mrzkt

cc:

A. H.

Freedman

C. Shogass

Fink,

M.D.

�</text>
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                    <text>nﬂmw“wv.€wmmn

&lt;Wv a, nu.WW

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E

5

February 25, 1971
Daniel Blain, H.D.
2100 Clarkson Avenue

Philadelphia, Pennsylvania 19144
Dear Dan,

There is one member of the Association, Joseph Zubin, who
has been most intimately involved with the association for half
its lifetime. He has written the most recent history (1965) and
I have asked him to answer your inquiry.

affiliated with Hillside Hospital, and
of the dramatic impact that Israel Strauss played
in New York psychiatry between the two World Wars. While Hillside's
impact on American psychiatry may be considered modest, it had a
great influence on New York psychiatry. Historical notes can best
be obtained from Joseph S. A. Miller, the medical director to 1961.
came

For ten years I was

to

know

Also, many research institutes were established with much
enthusiasm and optimism as the way to cure schizophrenia during

the 1950's and 1960's. I was intimately involved in setting up
the Hissouri Institute In St. Louis (1962—66) and notes about
this history may serve as an example of this trend. But then
you could document the centers in Omaha, Galesburg, Iowa City,
New York, 335,, with as much profit.
Good

luck in the project.
Sincerely yours,
Max

Mszt

Fink,

M.D.

,.

-.

.

�</text>
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                    <text>Wv»! u...

r

‘r—

«VP-um r'.‘ .—.~.vv««we W..,..,..—-mw

—-.—....mm_. .,... w...”

w.—»,.--u-u.»———-——w—v_.

,7, ..

,_‘__,

_f..‘..

.

.

- .. ...

v....._y—.—

w...

w. '7

,

w,

,

February 25, 1971
Dr. Michael A. Taylor
9309 Murillo Avenue
Oakland, California 94605
Dear Mickey,

I have read your set of ambitious and moat
them aeriatim, I made some

Both Dick and

interesting proposals. In reading

notes and these are included with suggestions.
In

4), I believe

sum, (page

you could

set

up a study of

lactate now, for application to NIMH before June 1. I think
this is the most fundable of the projects. The need for funds
is not obvious to you now, but will become obvious by the end

of the year. I am enclosing an outline of an NINE application
and a copy of our ECT application to give you an idea, both of
an application and Dick's ECT project. I suggest you write up
the sections on Aim, Methods (subjects), Previous work done
(by others, by ?.I.), significance, references. I can write
description of facilities and the budget.

For the

rest

~

a

neuro~endocrine effects in schizophrenia,

you will receive notes and reports
from Dick or myself to keep you up~to~date, but there is no urgency

penicillamine, ECT~depression w
in these.

The relationship with Kirby State Hospital is agreed to, but
the final steps can only be taken when a budget is approved. The
present ”freeze” on appointments to the State should be lifted by
April 15 and I am confident Dick will be in Kirby by that date.

It was a pleasure to read the notes. Try your hand at a
grant application.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hrzkpt
QBCB a

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                    <text>February 25. 1971
Dr. Allen P. Borger
Chas. Pfizer &amp; Co.
Groton, Connecticut
Dear Allen.
EEG

Enclosed is a supplementary statement regarding the
effects of thiothixene 1n depressive outpatients.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>.-.

r~ r

r.“

awn—u

mu r-‘vx—mwm-ur- n w -—.~- a- m-v"“".i.:-—-q—— .. , an».
V

- .3«r.¢rid"'xﬁn'w'u
.7
.

.n

r—r—rw

W
.

,
w—W...

, ,_ Mawqamw
Wm a, Nmmm-

worse—VT“‘v' “new..."

4

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w

vv.—n&lt;-—v.r.......w‘,....—.._... ,

V

W”

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m-

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”Fm-vwm-rm

February 25, 1971
.__,_

n
..

.

w-yb‘l-W-r—ﬂn'vrr‘r'

Dr. Peter Crown
Mediache Paculteit Rotterdam
Dr. Moleuaterplein 50
Poetbus 1738

Rotterdam, Holland
Dear Dr. Crown,

.7-

..~.,,.m.~,ww-w..-n

-

.a...

V

.
-

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4-

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"Irena-v

.
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mm.

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1hr."

zip-'77"

"PM“

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mat-9-

mums-(w

.myyun—r

m"

The

on clinical problems
of
our funds are in
sources

studies in the Division are focuased

clinical populations.
support of clinical treatment of in~pationta at Metropolitan Hospital
(studies of ECT: new drugs in anxiety, depression and schizophrenia);
the treatment of opiate dependent subjects (antagonists in opiate
dependence; methadone, heroin): and research programs in the clinical
pharmacology of cannabis, the quantitative assessment of EEG anoman
and the EEG effects of opiates.
and

The major

of operation can best be described as collaborative,
focussed research, designed by a project leader in association with
other participants. Projects are usually described in writing: critiqued:
and if approved by the Division, sent on for school approval. There
is a hierarchical structure in this Division and promotion is as rapid
as the studies and energy expended warrant.
Our method

You

should know that the Department Chairman

in biological

psychiatry and

is actively interested

is the principal investigator of the narcotic

antagonist and cannabis studies.

are integral to almost all our studies and these
Volavka and myself. In your initial assignment
Dr.
Jan
are supervised by
I would ask you to aasiat him in his projects. Right now his principal
work is the analysia of the ECT and methadone/heroin data. The
studies of marijuana effects on EEG and behavior are in the data collection
phase, and the next BOT/memory and chronic marijuana studies will begin
The EEG programs

data collection in March/April.

Our EEG work is concentrated on the ongoing
planning any averaged evoked potential studies.

signal;

we

are not

.\

um“, a...

�-W=_w-w»--«—~=-v.vw~‘-mI_meﬁ_-Hn.“.m—w‘s‘vmwvi—H«—‘H‘W17Z.Pw&gt;’n~w&lt;‘q._«—w“1r~__vvrrnw&gt;~w.1~“m‘r\'m‘~‘w‘“"'

mm

m-w..___m.v—m-.w._—w-w

Vi

u.

~.«

~—

Dr. Crown

..

..

r

w.... y...

7......“ -"-’~

Hl'vw'v-Vrv-c ”ml-t."

‘

February 25, 1971

~2~

Host of our space is used for laboratories and our office
facilities are very crowded. But we have learned to adapt for
there is a new facility with adequate space that was due for completion
the summer of 1970, and now should be available the winter 1971-72.

There are a reasonable number of research assistants. technicians,
computer console operators; and funds for equipment and supplies
are adequate. Travel funds are virtually noneexistent, except on

invitation, and these are fairly frequent. Secretarial aervices are
also restricted, so that most of us do our own typing (except for
final reports). Calculators, typewriters, computer time, library

facilities and copy facilities are freely available. Our teaching
commitments are minimal and the Ph.D. staff devote 992 of their time
to research.

associates will tell you, it is neither the best and far
from the worst of laboratories. Your "progress" will depend on your
energy and productivity on one hand, and on the rate which we meet
As my

our shortvterm goals.

work

I trust you will join us and udll find the same satisfaction in the
that we have found. If you have some more specific questions

about the EEG work I suggest you address them to Dr. Volavka. If
you have some questions about our organization or attitudes, you may
wish to write to Stanley Feldstein, Ph.D., Associate Professor, and
project leader in clinical cannabis studies; or Rhea Dornbush, Ph.D.,
Assistant Professor and a project leader in ECT/memory and cannabis

projects.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

wnanw—zma

w...”

_

�</text>
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                    <text>v—v—u—umx-u..-wv'ﬁw'V—mu‘r-wm‘w'ww-m-v _. rm.“ ..—._7l_.‘.......7‘.,._. w.... r. 7—77—
.

February 25, 1971
M. Stone
Seminars in Psychiatry

Mrs. E.

591 Morton

Street

Boston, Massachusetts 02124
Dear Hrs. Stone,

I have read the

to respond.

comments on

the

ECT

issue

and would

(1)

Redundancies between Fink and [Schildkrnut] are

(2)

I agree that the relation between psychotherapy

resolved.

is a

like

and

much neglected issue. Unfortunately, I know of no one
who has made a serious contribution to this problem since the
in the 1950's.
reports by Abse, Kahn and my co-workers, Jaffe —
If you know of anyone who can contribute to this question, I would
HOT

all

be delighted to invite such a section. I could ask one of my
Hillside canworkers, Harold Escover or Joseph Jaffe to write such
a section, but I know that they have no recent data.

(3)

The

for Indoklon.

Q &amp;

ECT.

and

A,

if

not the clinical.

contribution will focus

(4)

My

(5)

There are no new data that

on these
we

theoretic issues.

have found on drugs and

I asked that the data be reviewed in the clinical section,
if not there, I will put in some questions in Q A.
&amp;

(6,!) I agree that these are critical questions. Date may
and memory section. If not, I'll try to get some

in clinical
answers in T &amp;

be

single clinical section is for ECT; there is another
special proglrms described will be covered in the

The

A.

�--r W~

--

a":

v wv

~w~w~—-.—v—v—-vm.

«my...

'I’l'w-RHV

Mrs. Stone

.

,,

,,._._..-,,,,..,..

w..."— .7»

.-_...., v

n _ ...__..

M,

—2~

,.,...,..,.._._...,

.

.. -v. -..

February 25, 1971

I heartily concur with the reviewer's last

comment.

In

thinking about the questions about psychotherapy, combinations
with drugs, overtreatmant, abuse of ECT, etc., I think we might
consider a section on ”needed studies" or the questions that
might be looked at critically. This is a section that could be written
by someone with tho various texts in hand, noting the omissions
and needs. I can think of two men who could do this well - Milt
Greenblatt and Jack Ewalt. May Ichavo your advice?
thanks for the fine comments. I find the project
most challenging and trust we can get a fine issue.
Again,

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc: E. Bartmann

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                    <text>February 26, 1971

Secretariado Del

V

Mundial de

Congreso

Psiquiatria

Apartedo Postal 20—123/24

Mexico, D.F.

Gentlemen:
WCP

in

for

2

Enclosed

is our

Mexico City.

check

for $60.00 fOr

membership

in the

I wOuld also appreciate a reservation at the Camino
for arrival Sunday, Nohember 28 to December 4, 1971.

I have already accepted the invitation
symposium "EEG Correlates of Psychiatry."

Real

to participate inthhe

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt

1971

�</text>
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                    <text>February 26, 1971
Hr. Emil

New York

J.

Drysdale

State Narcotic Addiction

Control Commission
Executive Park South
Albany, New York 12203
Dear Mr. Drysdale:

Enclosed is a copy of the most recent voucher, which
includes the expenditures to 1/31/71. One item needs explanation.
Consultant fees will rise to almost $60,000 as we have let the
,

contract with

Food and Drug Research and payment

is deferred.

Sincerely yours,
Max

Fink, MJ).

Professor of Psychiatry

MF:kt

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                    <text>February 26, 1971
Dr. Fritz A. Freyhan
St. Vincent's Hospital
153 West 11th Street

New

Dear

York, New York 10011

Fritz,
Thank you

for the Opportunity to read the report

"An EEG

Loss During Alcoholic Intoxication" by Freeman,
Goodwin and Othmer. For the reasons described in the attached

Study of

Memory

critique, I find the report unacceptable for publication in its
present form. The subject is an important one, but the contribution
is too inconclusive to merit the space. I believe the authors have
better data ~ I hope they do, in any case ~ and that could be the
basis for an acceptable report.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
0116 o

�</text>
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                    <text>February 26, 1971
A. M. Freedman, M.D.

TO:
FROM:

Max

Fink,

m.

Chapter in Textbook, Tranquillizers in Psychiatry

SUBJECT:

it

I have read the chapter (35.1) as you suggested, and find
quite good and up~to~date. It is easy to disagree with some opinions;
to suggest that the emphasis be changed, but any criticism would be
minor compared to the major areas of agreement.
be

80%

If you

wish

this rewritten,

very similar to Denber's

less chemical,

I can do

article,

more neuroPhysiological.

it.

The

result will

but the emphasis will be

are correct in assessing an absence of data on lithium
Kalinowsky's section on miscellaneous therapy is weak.

You

therapy.

My principal hesitation is the personal
conflict with Hy. Please assess the risks and
to the gains, and make your decision.
Mszt

one of coming
damage

into

in relation

�</text>
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                    <text>v-r‘I-v‘

guru-WW.“

_

,

February 26, 1971
Dr. Frederick Gibbs
1427 N.

Chicago,

Astor St.

Illinois

60610

Dear Dr. Gibbs:
Your recent

EEG, I:
editorial (Clinicalw

127)

asserts that

"cannabis indica produces no marked or consistent changes in the
EEG" md ". .. the changes they [psychotomimetic drugs] produce in
the electrical activity of the cortex are of the same minor order
as are produced by tobacco“. It is difficult to see how you can
arrive at such sweeping conclusions, based on the data printed.
The report by Deliyannakis et a1. finds large effects of
cannabis, in a few subjects, with equipment of limited frequency
response. They make no effort at quantification and we have no
idea about the sample size, stability over time, artefact control,
Despite the limitations of equipment and technique,
filtering, etc.
they report large changes, albeit not in every subject.

In numerous studies of the EEG effects of heroin, LSD, major
changes have been observed and related to drug dosage, pro-existing
EEG and clinical effects
(for examples, see Ann. Rev. Pharmacology,
9:241—258,1969; Neuropharnacology, 9:539,1970). Such studies
show that large EEG Changes are common, drug and dose related, and

interestingly related to the behavior of the subject.

Considering the major strides made in quantitative EEG, it does
neither the science of EEG nor clinical practice a service to make such
sweeping assertions as "Let's face it, disordered psychic function,
either spontaneous or drug induced, commonly does not correlate with
major abnormalities in the waking electroencephalogram".

�Dr. Gibbs

~2-

February 26, 1971

Years ago we looked at the moon and saw a fairly flat surface
with a few ridges. With better tools. it became obiious that the
ridges, mountains and valleys were substantial. How substantial was
recently demonstrated by the astronauts limited ability to climb a
small ridge. The sruface EEG is not a homogeneous, insensitive flat
serface, but a sensitive, ever-changing reflection of mood, memory,
and

alertness.

use them.

Our

tools

Particularly,

do decode differences already, were we to
were we to look carefully, with the tools

of the 1970': not those of the 1940’s.

Sincerely yours,
Max

Fink, “.0.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>rrwmwawm-

37w...

-,.-, -

“—-\. ma

.

.prrre.‘

.

,gf
Mr.

Earl Ubell

51 West 52

New

Street

York City

’

’
_.

;;7;5¢f
"
é

T'

_

la:

jf’

:‘_,

"

*Jahuary 1, 1971

_

.7”~'

'ﬁﬁf‘

».--..1 f_s$

ﬂ

‘

Dear

Earl,

l
your

the local
series for
National Academy used excellent judgment in citing
excellence. I do hope there will be a chance to make this series
more generally available as one overview of the drug use problem.
There is one optimistic sign on the college scene, that drug use
may in fact be decreasing as this new wave of meditation sweeps
various campuses. My son tells me that drug use has fallen off at
his campus as more than 200 students are meditating.
Congratulations on the award for Drugs

A

to

——

Following your suggestion, I reached Joe Lelyveld of the
arranged for both Altman and Severe to call
about a presentation. Severo was also called by NACC's chairman,
Milton Luger, who was concerned that his commission's role in the
program had not been acknowledged.

new York Times, and he

...

.1..."

r...

,,_.,,,_,

Thanks again
newsworthy 1971 !

for your advice;

my

best wishes for a
Sincerely yours,
Max

Fink, M.D.

most

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                    <text>January 4, 1971
Dr. C. Stefania

Eginition University Hospital

Vassilissis Sophias
Athens, Greece

74

Dear Costas,

Since we have finally received the agreements that make the
study in Athens feasible, we have examined the protocol and I am
now writing to propose a plan of study. As we reviewed the records
we became impressed with a number of issues: the population sample
and

its characterization,

for each subject of the total

tests

and records to be obtained
sample; the earlier records and their

the data,

and examination for comparisons; the problem of controls;
and
staffing — and all these before the actual detailed
a timetable
examinations of the definitive sample are undertaken. Also there are

availability

administrative problems, as to the funds, our visits to Athens,
housing and subsistence ~ but these will depend on how the project
some

unfolds.

Population sample.

we

are impressed that the description of

the total sample is most important to any conclusions that may be
drawn. we envision a sample of chronic hashish users, some of whom
have records from earlier studies. Since a small sample will be
studied intensively, it is advisable to provide as full a medical,
psychological and social picture of each subject, and of the total
sample from which our test sample is drawn.

view the sample and study in two phases ~ a global overview
and a detailed examination of the snail sample. Is it feasible to
do this sequentially with a few months hiatus or must we complete the
examination of each subject as we get him?
we

provide a basis for the data collection we have made up some
outlines of our suggestions of the data we would like to obtain for
every subject.
With regard to the psychological tests, we have tried to find
tests that have been validated in Greece but have been unable to do
so. Do you have any suggestions?
To

�Dr. Stefania

January 4, 1971

~2-

With regard to the neurological survey, it would be important
that this be a detailed survey. We believe we should make up an
examination outline that would include all the tests indicative of
organic brain disease and of peripheral neuropathy, similar to the
problems one would anticipate in patients with chronic alcoholism.
we are unclear whether the tests used in Athens are derived from the

German/English

literature or the French.

Could you supply us with

outline of the neurological examination in use in your hospital?
Early records. We are aware that Professor Miras has extensive
records of hashish users examined in the past. To what extent will
the present sample be derived from that earlier population? Are we
to make any effort to trace that earlier population, and what study,
an

if

any, should be focussed on

this earlier data?

Controls. The value of our study hinges on the population from
which we select our test subjects and on the adequacy of our controls.
If we so decide, shall we have the Opportunity to use siblings or

relatives of index cases or other as controls?
Timetable and staffing. My schedule is such as to preclude any
activity in Europe until early March. We would like to plan the various
steps of Phase I now, anticipating the period March 15 to May 15, as
the period for the initial sampling. we would use the data of that
sample to plan the second, detailed examinations, looking forward to
doing these studies during the period of June 1 - September 30.

For staffing we would propose that I join you in early March
for such planning as may be required. I will be accompanied by
either Dr. Feldstein or Dr. Dornbush who will provide for the

psychological aspects of the study.
During the

first

phase (interviewing the sample) one of our

staff will participate. we will ask you to provide the remainder
of the staff. Particularly we believe the social worker-administrator
and a

bilingual interviewer should be appointed

population and perhaps
provided by Dr. Miras.

make

the

initial lists

soon to identify the
or surveys from data

We have a special staffing need, that of a cultural anthropologist,
one who knows Greek history and culture, to assist us in characterizing
the sample. It would be ideal to have someone who has been trained in
both countries. We have not been able to find such here, and would ask
that you inquire at the University.

�use...

.,.&lt;...........‘W,,._

r,

‘_.m..r..-ryw—&lt;u.un:.-wf »

r$"’u.v~Vw—5v-'r.:‘a. ,.

Dr. Stefanie

I

am

”we“. ,4."

.

r

-,

n1;

»

‘

“er

~

; n» —&gt;vd-'I"&gt;'«smarn‘

.v

-3~

‘

es

.7”

-&lt;Iw.-»

»

.. m,"r;—w‘"xvn

'

*—-~

.,

-

.

w--

w--

January 4, 1971

enclosing our suggested outlines, timetable end proposed

staff arrangements. These working documents are suggestions to be
revised by you. The timetable is an optimistic one, dependent
completely on your staff work. Wbuld you revise this to make it
more realistic?
best regards
interesting venture.
My

and

best wishes for the success of this
Sincerely yours,
Mex

Fink,

M.D.

.Executive Director
Mrzkt

~'

A

�PROPOSED SCHEDULE

January-February

Planning, identification of population sample

Staff appointment
March 5~15

First

work sessions

in Athens

Pilot interviews
Checking Interview instruments
Reviewing the
March 304May 15

early

Miran data

Population Interviews: Goal 100 subjects.
Psychological, social medical data

May

15-30

Planning Second Sample
Data Analysis
Sample

June 1-Sept. 20

identification

Definitive

sample survey

neurological,
October

EEG,

Data evaluation

-

drug samples

�</text>
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                    <text>January 6, 1971
Dr. Arnold

J. Singer,

Chairman of the Board
Reed and Carnrick

Xenilworth,

ﬂew

Ph.D.

Jersey 07033

Dear Dr. Singer:

recent meeting of investigators interested in cannabis,
the proposed program next spring at the Academy of SciencesWewas
have
mentioned as a public presentation of the available data.
the
and
believe
two
studies,
recently completed the analyses of
data to be relevant and possibly sufficiently novel to be of interest.
At a

have established the EEG profile of cannabis as inhaled by
experienced users, in both acute single trials and in chronic (daily
x 22 days) use. Subjects smoked cigarettes containing the equivalent
of 7.5 mg or 22.5 mg THC. The data allows us to classify this compound
we

by
in relation to the EEC profile classification previously published
Of
and
special
others.
1969)
by
us (Ann. Rev. Pharmacol., 2; 241-258.
use ~ changes
interest are the changes in EEG profile with chronic
We
would
behavior.
propose the
which are associated with changes in
and
M.D.
Volavka, H.D.
Jan
Max
Fink,
title "EEC Profile of Cannabis", by
on immediate memory. and the
and
of marijuana. These data
dose
relation of the changes to task
Jones and
differ from those presented recently by Kiplinger,
of Cannabis on
”Effects
of
We
would propose the title
Tinklenberg.
M. Freedman, M.D.
and
Alfred
Ph.D.
Immediate Memory", by Rhea Dornbush,
Our second study

is of the effects

There are two additional issues that are of interest to us
that may be discussed at the conference. In oscwchronic trials, we
have noted a decrease in "tolerance" to cannabis, the subjects
developing dxpphoria after one week’s use. We are assessing the
possibility that smaller doses may be needed after repeated
exposure to achieve euphoria, and the recent reports of persistent
tissue levels of cannabinols may be an interesting contribution.

�.r—

.

v...“

-

.-

.

ww4.v"v.«

2.-

('~‘-'

(Aw—r m...»

Dr. Singer

.

.n-g

.7:¢'v.v-vv&gt;.

.-

,,

......,

~o~l+w

..

.

,

~2~

.N-..

in",

._

.

«~

4

new” .‘..

,em

.12.“.

.,

_

.

.

”1,.

January 4, 1971

have recently received a contract to study chronic cannabis
users in the Near East, to assess the evidence for persistent sociological,
social, and neurophysiological changes. In working through our tests
we

and sampling techniques, we became involved with the problems of

establishing adequate controls for the chronic drug user.
It may be useful to discuss these two
the problem of
"tolerance" on chronic use, and adequacy of issues,
population samples for
chronic trials, should the conference wish to review the immediate
research issues.
Our programs have been

Institute of mental Health

substantially supported by the National

if our
can
contribute to the success of the proposed public presentations.
my best wishes for the success of the conference.
and we would be pleased

Sincerely yours,
,.

,

Max

7””?va

_.

.:
«
ewe-nun

Fink, M.D.

Professor of Psychiatry

MF:kt

data

,

5

�</text>
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                    <text>.4...‘..v_—..,..;..7. 37

i.

..- ...

.

H. V;

Tee. .‘gnr

q... wr&lt; .n‘ ,....,. a...vewmqwava—wuv«Fraser»

w’rmg" 'Jnviiw’ﬁvrrrz'w'wtr-‘ra

—-

»

N-t-Fyrn- «w , u

"r

.-

-1..;('. urn: .gnm'u—vw' w. .-

'vgwi: c

urn-rm» w;

.s—m-

,.,

January 8, 1971
Dr.

J.

Mandela

Associate Professor of Psychiatry
Department of Psychiatry
c/o V.A. Hospital
University and woodland Aves.
Philadelphia, Pennsylvania 1910&amp;
Dear Joe,

Enclosed are two copies of

contribution, "EEG and Clinical
Psychiatry", for the textbook. I have elected not to include a
number of EEG figures, since these are ably reproduced at greater
length in the citations. If, however, you believe the report may
be improved by examples, I will submit some representative figures.
There

is

a

my

single table. reproduced

from my 1969

report.

If

acceptable. I will write to the publisher for permission to reproduce.
your

I trust the report is useful,
invitation and your patience.

of this volume.

for
best wishes for the success

and I thank you once again
my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
one o

--

7-

-

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                    <text>January 8, 1971
Dr. John Schinel
£0 Granercy Park N.
New York. New York 10010
Dear Jack,
Enclosed is a revised version of "Toward a Rational Theory
of Behavior" for Career Directions. I have made the deletions
suggested by the editor, and almost all the changes in text which
I could. I hape this ”compromise" is satisfactory.

In re~reading the text, perhaps it may be useful to add the
citations as sources where the observations are reported in more

detail.

My

thanks for your cooperation.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

MF:kt

enc.
cc: Freed Scheel

0.3. Publications
299 Park Ave.

New

York, N.Y. 10017

�</text>
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                    <text>Jr.

H. M. vanPraag

January 8, 1971

Psychiatric University Clinic
Division of Biological Psychiatry
Dostersingel 59
Groningen, Holland
Dear Dr. vanPraag:

a fortunate coincidence, your kind letter and invitation arrived this
I was entertaining your countryman, Dr. Geerlings, whom I found
delightful and who described your projected program. I would be pleased (and
am honored) to accept your invitation to discuss the issues of
opiate dependence,
particularly the problems of CNS effects of opiates, and our present treatment
models. With your permission, I would like to describe not only the experiments
with heroin and methadone, but also those with the antagonists, cyclazocine
and
naloxone.
By

morning as

In addition, we are actively involved in the evaluation of chronic cannabis
use. I should be pleased to participate in the cannabis discussions, particularly
the problems of evaluating chronic effects. we have recently received a contract
to study a group of chronic cannabis users and have had to make many compromises
as we faced the actual data collection.

I plan to be in Europe in March, and plan to visit Amsterdam probably
end of the month. Perhaps we can meet to discuss your
the
near
program
further.

Again,

;

my

happy 1971 and

thanks for your kind invitation,
for the success of the meeting.

and my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mfzkt

best wishes for a

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                    <text>wr.”

v... — -ww-—\—- ‘wastuw w-F‘féE-wﬂwm'm
.-

w.“

..

wan-wu-

w.-

"‘4’“! .0.

z-m-y «aw-un-

January 11, 1971
Dr. Edgar Grunwaldt
Gcigy Pharmaceuticals
Ardsley, New York
Dear Ed,

have reviewed the two case records of the ketipramine~
iaipramine study and can resolve the apparent discrepancies.
We

Frieda Ehrenberg.

clinic.

Patient

was

unreliable in attending the

she received active medication and an appointment for March 10. She returned 1/2 box of medication on March 11,
indicating she had stepped medication earlier, estimated as 3/6.
She was referred for group therapy. Her follow~up laboratory test
on 3/17 was evaluated as on no active medication.
On March 3

Millie Mauer. On 2/17/69 she received ketipramine. She
had no medication from 2/10 to 2/17 due to a missed appointment
on 2/10. The laboratory tests were done before the new supply
was given. Since she had no medication for one week, test was
adjudged as on "no medication".
I trust this data is useful.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:kt

«Jarv—

�</text>
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                    <text>January 12, 1971
Center Industrial Electronics, Inc.
15-17 East 16th Street

New

York, New York 10003

Gentlemen:
Kindly give bearer the items listed on the attached
xerox copy and charge our account. The approximate sum is
$50.00.

Sincerely yours,
Fink, M.D.
Executive Director
Max

MF:kt

�</text>
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                    <text>Firing...

_

;

~.

.

.

.

~,——~w

,

\1-‘_v-'-"I.quw'-Word—Vanna”.mun—war"

January 11, 1971
Dr. Louis A. Wienckowski
Barlow Building - Room 10A23
5454 Wisconsin Avenue
Chely Chose, Maryland 20015
g

i
gr
F

Dear Lou,

Martin called to ask

"mm/v

APPA.

if

you were indeed a member of the

W,

3.

Of

my

"away.

-..,...._..

The

Association extended

ship invitation form, as requested.

,.

m.;m—.w-.«

-

course!

spring, to which your office responded
you

in

Glad to have you as a member, and
New York in February.

Incidentally, your dues are $10.00

Arnold Friedhoff.
my

best wishes for the

New

its invitation in

I look forward to seeing
and may be send to

Year!

Sincerely yours,
ﬂax Fink, M.D.

Secretary

HF:kt

the

by completing the member~

�</text>
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                    <text>.

January 11, 1971
Dr. James N. McClure,

Jr.

Eastern Missouri Psychiatric Society

Lindell Blvd.
St. Louis, Missouri
3839

63108

Dear Jim,

I am pleased to recommend Jovan Simeon for membership
in the Eastern Missouri Psychiatric Society. I have known
him since 1965. He is a sincere, thorough, conscientious,
knowledgeable psychiatrist and I recommend him highly.
Sincerely yours,
Mex

Fink,

M.D.

Professor of Psychiatry
MF:kt

m

Wm'vvw‘:

my Tut‘s-u.-

�</text>
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                    <text>w;

v—.—

n’
"um-m, -—m._~...
1

”yum.

,4

... ..

um. «mnmgx‘WSJVw‘lJrh~H1-‘
.

,

.

-

~

,
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7

- ~.

,

,

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-mm. "
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4

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.w....~..r.. ‘ mm- " 3...... yum:

mm“

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w-v-

'-"

""“""-“‘~“

January 11, 1971
Dr. Marion Finkel
Food and Drug Administration
18733 Walker's Choice Rd.
Gaithersburg, Maryland 20760
Dear Dr. Finkel:

the

An
FDA

announcement

in the "Blue Sheet" that your office at
new drug evaluation, and the

is reviewing guidelines for

knowledge

that

send to you, a

Dr. Dorothy Dobbs has left the FDA, prompts me to
letter sent to Dr. Dobbs on December 1.

"Some weeks ago I received an inquiry which raised my
concern. Would I be willing to undertake an EEG study of

anti~obesity agent since the PMA guidelines for evaluating
such agents includes the phrase: "Consideration may be given
to a small EEG sleep Study”? my question is whether the
restrictive work ”sleep” should be included.
an

I\.wr£"

“qua...”-

.

ur-vrv

..-,

m...

«4

-cmr~.u,

mmmww

At present, quantitative EEG studies of psychoactive drug;
effects have a firm foundation in techniques of EEG analysis,
in the classification of drugs, and in the identification of
new psychoactive drugs. The literature is most reliable for
studies in alert subjects, and it is in such populations that
discriminations have been best made. Other data exists for
sleep, evoked response and contingent negative variation measures.
The literature of the latter twomeasures is
sparse.
For sleep, there is much data of a descriptive kind and of
generally limited value, since samples are small and studies are
few. The principal students, Oswald, Itil and Kales, are not
agreed as to drug specificity, or the relations of dose or
duration.

«

I'm-e

I'Kful

"um-wz'rk‘wmwmnw

war—W

w-

um

"WV-v

"a...“

In view of the possible value of EEG studies in clinical
psychopharnacology, may I urge that any FHA—FDA guidelines which
may recommend EEG studies, do so without a ”sleep" or "alert"
restriction? (Incidentally, such studies may also be useful
in bioavailability studies of all psychoactive drug classes,

and in classification of anti-psychotic, hallucinogen, stimulant,
anti-anxiety and saporific drug doses.)"

�Dr. H. Finkel

January 11, 1971

—2-

I am enclosing a reprint that summarizes the data to 1968,
and a more recent report. I would be grateful if you would accept
these comments and reports for your deleberations, and I thank you
for your consideration.

Sincerely yours,
Mex

Fink, M.D.

Professor of Psychiatry

MF:kpt

enc

o

�</text>
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              <elementText elementTextId="46933">
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                  <elementText elementTextId="106122">
                    <text>"' «'"v‘w

'

-

'v

‘

.‘vlvriv‘l-V

vny'ogvr-wvtﬁeunh.

-

—.v-,..w....‘rp.)v.an,—.v

.,.._,.w.,_.;.,,¢ ”v.7. «m.

.

u

,,

,.

.

.,

“7.7,. *m'

,._».,,.

"my

.

..,. ,

,,‘_.

, .,

..

VWWHM, r,“

, _.,

January 11, 1971
Dr. Donald F. Klein

Hillside Hospital
75—59 263rd Street

Glen Oaks, New York
Dear Don,
Thank you for the descriptions of your-evaluation program
and the 1967 annual report. I will kepp your request for personnel
in mind, and bring it to the attention of our residents.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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won-yumwm

."tq'c'o

January 1A, 1971
Dr. William Cooper
Winthrop Research
chssalaer, New York

Sterling

Institute

Dear Dr. Cooper:

are interested in continuing our studies of cyclazocine.
present we have 52 patients on continuous treatment and are
inducting new ones at a rate of 1~3 each week.
We

At

we have recently had some crises about the supply of medication
and I am writing to request a continuation of our present arrangement,
$42;9 a monthly shipment about the first day of each month with an

increase to

300

bottles, addressed to:

Dr. Arthur Zaks
Department of Psychiatry,

Metropolitan Hospital

Room 15A9

1901 First Avenue
York, New York 10028

New

Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

cc:

A. Zak:

�</text>
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                    <text>a
I

w, mm. 7"

&gt;‘W‘YJVWK’

Tww‘;-

..

.

-

a,

.

m“—

..

7

.

»

,

,

_

,

.

—"v

--

”um-an

,

.

w: xn'-lw1—.Ivvw-rcrva'h'lz'V'l'lV».mHIi-m"~~«.r. Av-‘vz-u’vsnwwma'«'ﬁ"u

January 14, 1971
TIAA/CREF

730 Third Avenue
York City 1ﬂ017

Ref:

New

A—195755«2

P—11é771-4

Gentlemen:

I should like to enquire as to the availablitgy of certain
options under the two policies cited above.
Can

will

I change the retirement date to age

55 (1978)?

If so, assuming continuation of present payments,

be the monthly payment on a 10-year

what

certain contract option

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
39

Arleigh

Great Neck,

Road
New York

11021

?

�</text>
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                    <text>_(

"

'u‘n

'

.

,

.1

4.,

‘W-‘“

w-vmo waswmrw—WWW
)2

-

'1‘.’

January 14, 1971

War...“

60th

Dr- K.
Koxhor 11
Amsterdam

Dear Dr. Cohen:

Dr. Peter Geerlings visited on this wank and in charing the
descriptions of our programs in substance abuse, we found much in
common including an interest in the long term effects of cannabis
(hashiah). When I doacribcd a project we are carrying out jointly
with the University of Athena, he told no of the presence and
possible availability for study of chronic hashish users in
Amsterdam, and of your studies. Our project is to assess the psycho»

logical

and nourophysiological status of chronic hashish users,
1965-48 and to be rc-oxamined by us this

identified originally in
summer.

It may be particularly useful to carry out parallel studios
in another population. Is thero a population of chronic hashiah
users who can be idcntificd, and who might cOOperate in acne
would you with to estimate any characteristics
(age, duration and amount of use?)? would it be of interest to
you to discuss such a study?

examinations?

I plan to be in Amsterdam in late March and could arrange to
meet to discuss the project in Athens, and any comparison in
Amsterdam.

in

Dr. Gearlingc sends his regards:

March.

he

indicated he
‘

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mszt
cc: P.J. Gocrlings

would

return

�</text>
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                    <text>w

.u -"\v“‘~av WM»1¥F'W‘M-kw‘~7'v"v

w

.a

ivxwa-www ~17“

.

p-wy-wwum

Maw-”Vi!7.

January 14, 1971

Noahpitz“ ‘za

Mr. Joe

Hillcrest Childrens Center
1325 W. Street, N.W.
Washington, D.C. 20009
Dear Joe,
many

felt

It

was an unusual pleasure to meet once again, after
years. Mel and Blanche have spoken so often of you,
the gap in time was momentary.
as

if

these

that I

We have had little opportunity to apply our ideas to the study
of childhood disorders. The observations that stimulant drugs improve
the behavior of hyperactive children provides the basis for a
speculation in these children that is testable.

(1) The stimulants used, dextroamphetamine and
methylphenidate, alter brain function in a way that is reflected
in the EEG as increased fast activity, increased Inriability of
frequencies and decreased amplitudes.
(2) Quring childhood and adolescence, systematic
”developmental" changes in brain function occur, and these are
reflected in the EEG as progressive amplitude decrease, increased
regularity of rhythms (decreased variability) and increasing faster
frequencies, from the usual 4~6 cps of the young child to 6~8 cps
of the pre~adolescent to 9—11 cps of the adult.

it be that a characteristic of hyperactive
record more immature than their age, and both
successful treatment, a change is induced toward maturation (and
in unsuccessful treatment, the change fails to occur)?
(3)

children is

to

an

Could
EEG

enclosed summary of our
are enclosed.

The
ECT
My

EEG

theory and an earlier application

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

MF:kt

�</text>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="1">
                  <text>Correspondence</text>
                </elementText>
              </elementTextContainer>
            </element>
          </elementContainer>
        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
    </itemType>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46874">
                <text>Correspondence to: Noshpitz, Joe</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46875">
                <text>Text</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="46876">
                <text>mfp-05-00-025-1-065</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46877">
                <text>1971 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46878">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46879">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="46880">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46881">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="46882">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="46883">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="78890">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="85451">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="92012">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="98573">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
