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                    <text>n ‘wwwvmmwvm

w w—wv

Juno 28, 1971

3r.

R. Mechanism

“threw Univarsity of Jerusalem
School of Pharmacy
P. 0. Box 517
Jerusalem, Israel

Dear Dr. Mechoulau:

Septratoly, I am sending you the available notes from our
present contract with Food and Drug Research Lacs. It would be
helpful to have another laboratory invostigcting this problem,
and I hape you can proceed.
I met Dr. Loev in Philadelphia two weeks ago, and we discussod
a systematic study of the TWEIJorivativo. Ho and his associates
cannot release the compound unless either they or we file an 1&amp;9
application with our FDA, an&amp; I left thou coasidorinﬁ their filing

the applicntion.

Moanwhilo I met Professor W. R. Chou at tho University of the
Indies and he reported isolating some now derivatives of
Jamaican hemp. The formulae are onclosod for your intorest.
West

I was pleased to know that your THC is stable and active. I
will uso the runnining matcrial in some experimental studies. The
information was most holpfhl for our relations with our chemists
My

best rognrds,

and my thanks

for your continued interact.

Sincoroly yours,
Fink, M.D.
Profbssor of Psychiatry

Max

MF:kt

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                    <text>June 28, 1971
Dr. Bernard Loev
Smith Kline G French Laboratories
1500 Spring Garden St.

Philadelphia, Pennsylvania 19101

Dear Dr. Loev,

It

pleasure to discuss your interest in THC
derivatives and I do hope that you can arrange to make
supplies available for BBC studies this fall.
was a

visited the University of the West
Indies in Kingston to review their cannabis study program
for NIMH. I met Professor W. R. Chan and Dr. K. E. Magnus,
and they described two unusual derivates of their hemp plant
which they have isolated. Their formulae and a citation of
This

last

week, I

a similar product isolated by Obata and Ishikawa ace attached
for your interest.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MFtkt

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                    <text>June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�June 28, 1971
Dr. Michael H. Beaubrnn

Professor of Psychiatry
University of the west Indies
Department of Psychiatry
Kingston 7, Jamaica

Dear Dr. Beaubrun:

Since returning to New York, I have had the occasion to
report our discussions to my associates and to NIMH.

it,

Should you wish
I believe another study is feasible
and can probably be supported. We can prepare the study design,
and provide the necessary staff and equipment to assist your

personnel.

The

here,
early August.

timetable of January-April 1972 is feasible
if we provide the necessary data by

and may be supported

For its success, the project will require your recommendation
of two staff members ~ a registrar~psychiatrist and a project
coordinator. The registrar should receive some training with us,
and be responsible for the medical-psychiatric aspects of each
experimental session. If he were available now, it may be useful
to have him participate in the actual proposal-writing. The
project coordinator should be capable of identifying the subjects
and arranging for their availability for study. Such a
person, if
named now, could also participate in the write-up.
and

I would like to recommend the active participation of Drs.
Stuart in this phase of the study.
I believe there should be two preposals

the physiological

(EEG,

ganja.le

~

Ward

a short-term study of

cardiovascular, respiratory) effects of

Jamaican
marijuana, and TliC~free cannabis; and a long
term study of the Jamaican population, to continue to define the

psychological, medical, and biological efﬁects of chronic ganja
use. Both proposals may be funded through a U.S. non-profit agency
should you concur.

�</text>
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                    <text>up."

"—5:

ﬂux:

mun-NW"...

wwwWMmm-w-ng-r

elm-1":

June 27, 1971

.,.,;

u
&lt;

minnow-Wu

vu-

«-

.,

Mrs. B. Engelman &amp;
Mrs. Bronia Fink
528 Manor Ridge Road
Pelham Manor, New York

WWMWNII'A‘I'

Dear

Berti

Stringaris

&amp;

Bronia,

The

first

with the rest, I believe
literature on hashish.
I have
on both

the translation of the
excellent 1 If you can do as well
will be a major contribution to the

two pages of

volume on Hasyish are

two

it

suggestions:

text, and use slightly wider margins
send you another ream of paper.

Double Space the

sides. I will

Please arrange to purchase the appropriate dictionaries
that you will find necessary, and send me a statement for reimburse—

ment.

v.

.,,.,:.,

Many

thanks.
Sincerely,

.,
.~

”.1575

jg.

’e

eIf
3%

5;
9s

ig.
S:

E
.‘

�</text>
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                    <text>June 30, 1971

Christian C. F. Spshr, Jr.
Editor, Lea &amp; Febiger

Mr.

600 Washington Square

Philadelphia, Pennsylvania 19106
Dear Mr. Spnhr:

I

have read the chapter and the index of the preposed book,
or Abuse, and find nothing of significance to suggest

Drugs: Use

its publication.

The reporters listed are parochial, and without a public
record of experience in this field.

matcrisl submittod is a saphomoric synopsis of better
summaries, as in Goodman and Gilman (Ed. III) and Drill pharmacology
The

texts.

The only persons for whom the book
students and relatives of the authors.

may

be of

interest arc the

SinCersly yours,
Fink, MED.
Profossor of Psychiatry

Max

HF:kt

�</text>
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                    <text>June 29, 1971
Dr. Roger Meyer, Consultant

Drug Abuse Control
The White House

Washington, D.C.

Bear Roger,

It

to talk to you. Enclosed is a recent letter
sent to the New York City Health Servicoa Administration for
support for the next step for us for MrSOSO.
was good

Should you wish to include such studies in your recommendation,
would be able to provide the data to support studios of a long
acting noloxono for parenteral or oral trials, and extend the

we

clinical trials
Good luck

now

in progress.

in your programs.
Sincerely yours,
ﬂax Fink, H.D.

,

Professor of Psychiatry
HER:

�</text>
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                    <text>1"

‘

June 29, 1971
Dr. Jonathan 0. Cole

Superintendent

Boston State Hospital
Boston, Massachusetts 02124
Dear Don,

In l96h665, in St. Louie, Turen and I studied the effects of
thioridaaine (5 mg/kg), chlordiazepoxide (1 mg/kg), each alane; and
thioridazine (2.5 mg/kg) and chlordiezepoxide (0.5 ng/kg) combined

in a croseover design in 24 chronic schizophrenics. Dosages were
maintained for 8 weeks and there was a placebo period of 8 weeks
between each dosage.
The

clinical effects have been published,

as anticipated.

and the findings were

In the EKG, BR, EP and hemogram data, we found consistent
changes with thioridazine alone or combined, and not with

chlordiezepoxide.
The

was

EKG

changes were not striking to me, but the consistency
age of the subjects.

related to the

In the next years, Turan studied high dose fluphenazine and
butaperazine and with both drugs, found similar EKG changes but

significantly less frequently.

In my hands, there are no differences in clinical activity
between thioridazine, fluphenazine and butaperazdne. Since fluphenazine
exists in 4 different formulations, has a very high therapeutic/safety
margin (doses fro: 20 to 1200 mg have been given by us), and induces
little or no EKG changes, I see no Justification for continuing the
use of thioridazine (ace Ban, pg. 150).

�,ww

Dr. Cole

June 29, 1971

~2~

Similarly, I

wonder about the very rapid approval by the FDA
of meeoridazine, a sister compound, for which seemingly excessive
claims have been made (in therapy of alcoholism and anxiety). In
the Sande: date, the EKG changes are said to be equal to thioridexine.

So, my view for both compounds is tempered by the variety of
antipsychotic drugs available, and the suggestion of greater effects
on the EKG. Since I cannot fairly judge the significance of these

effects, being unwilling to

deny them, and attempting prudence, I

that the use of thioridezine be limited to those
specially trained in psychopharmacology for research purposes.

have recommended

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
HF:kt

�</text>
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                    <text>April 1. 1971
Dr. B. G. Dinin

Commiasioneeradical Director

Grasslanda Hospital

Valhalla,

ﬂew York 10595

hear Dr. Binin:

I

pleaaed to accept the appointment a3 consultant in
the Division of Psychiatry at Grasslands Hospital. I look
forward to joining Dr. Gaylin in the clinical training and
research programs at Grasslands, and truat that I may be
am

useful.

Thank you

for your consideration.
Sincerely yours,
Mu; Fink , N. D .

Profcsaor of Psychiatry

MF:kt

�</text>
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                  <elementText elementTextId="103457">
                    <text>rimmwwww.

www.mwmmmwmw

_.

_

!

E

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'Psyohiatry this month,
understand why you called some months ago. If, indeed,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>April 2, 1971
Dr. William Guy

Biometric Laboratory

St., N.W., Room 618
20037
D.C.
Washington,
1145

Nineteenth

Dear

Bill,

is a dibenzothiepine derivative. It is
lO-dimethylaminomethyl—dibenz-[b,fl-rhiepin—HCI. It‘d
formula is:
GP

41299

Lhz-ﬂﬂ- ((3113)::
s/\‘T/
'
'3

It's

1

\--,,A-)\;/\/

molecular weight

I trust this

\§/\

is

.

(:1

303.9; melting point 263°C.

is useful.
Sincerely yours.
Max

Fink, H.D.

Professor of Psychiatry

�</text>
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E
p.

April 2, 1971
Dr. Sidney Malitz
York State Psychiatric

New

722 West 168th

New

Street

Institute

York, New York

Dear Sid,

In reading the American Journal of'PByahiatry this month,
understand why you called some months ago. If, indded,
the APA has requested a report on the pharmacotherapy of opiate
dependence, it would be useful to have the data Ind experiences
with antagonists as part of the record and consideration. The
possibilities of significant help to addicts by antagonists are
sufficiently viable to be seriously considered.

I

now

Good luck!

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Me:

MP:kt

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April 2, 1971
National Library of Medicine
Bethesda,
Maryland

Gentlemen:

I am anxious to obtain a copy of the following volume which
available at the New York Academy of Medicine or the major
not
is
medical school libraries in the city:
Monographian Ana Dem Gesamrgebiete der Neurologie
und Paychiatrie. Vol. 68, 1939. Stringaris,

It is

M.

an essayy on hashish.

If this is available at the Library I will

request through the

New

make a formal

York Academy of Medicine.

Thank you very much

for your assistance.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

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                    <text>r ww-wwwwra

Mar

wx—w—nwm

-.

.

April 5, 1971
Dr. G. Marjerrison

Associate Professor of Psychiatry
Univeratty Hospital

Saskatoon, Sask.

Canada

Dear Gordon,
Thank you for the notes about left temporal EEG accentuation
of slowing after seizures with bitemporal electrode placement.
Recently, J. Volavka repeated the measurements with our detailed
quantitative methods, and there is little question that the
difference is there. I don't know how we missed this in our
studies in the 1950’s, but we did miss it. We have no explanation.
We are
repeating the study, with spinal fluid chemistry
different electrode placements, and hopefully, monitoring themeasures,
seizures.
This last is a technical problem which is under study.
I hope to attend the last day of the 33? ~ (there is a pharmacology
meeting in Atlantic City on Friday~$eturday, and I am scheduled to
speak there).- and look forward to seeing you there. Many thanks for
the note.

Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>April 5, 1971
,

7p”!

-v-'uu-

rum

,

Dr. Michael O'Neill East
Pfizer Pharmaceuticals
0.8. Clinical Research Unit

Groton, Connecticut 06340
Dear Dr. East:

UK

7007 and

I believe

carry them out and we will review the data. He
is due here for a briefing and review during the week of April 12.
and I will go over the schedule with him at that time.

that
Wm"’mwﬁm-».w‘erW/m?f'hwy-”'4'”-

I have reviewed the protocols for

Chuck can

It

should be

interesting.
Sincerely yours,

W

W

Fink, M.D.
Professor of Psychiatry

Hex
.-.—

MF:kt

�</text>
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                    <text>,

,,

now

sympwﬁwi.mmmug—ramw-«uww-mu--.. rw'V'r'r' 'v:~r“.wW'-;

'VVI“."Y'V:A&gt;=-I;F:y,...

April l5, l970
Dr. P. Kieihoiz
Psychiafrlsche Universifafsklinik Basel

Wilhelm~Kiein—S+rasse 27
4056 Basel, Swifzeriend
Dear Dr. Kieihoiz:
i

have received various letters from The CiNP Program
my answer To fhe lafesf is enclosed.

Chairman, Dr. Vinar, and

i. The symposium Thai
Tifles lisfed.

has been submiffed

conslsfs of

The

2. The co—symposium is To be made up of submiffed "free
communicaflons". My leffer To Dr. Viner suggesls we could have
all l2 (absfracfs enclosed) bu? would prefer i-8, sugges+ing
9-l2 +0 be presented in The "Free Communicaflons”. The decision
is To be Iefl To Dr. Vinar.
3. He asks The? one of us summarize The proceedings in
fhe Plenary session. Since i am presenfing in fhe symposium,
would if not be eppropriefe for you +0 summarize The sessions?
i

would be delighled To have you do so.

4.

The papers of The symposium and co-symposium may make

find issue of a Journal, and i would ask if you would consider
lhis for your Journal, Pharmakopsychiafrle? (incideniaily, your

a

leffer of February

9 was

nof clear whefher you did indeed wish
a subsequenf issue of

reporf on anfegonisfs and mefhadone for
Pharmakopsychiafrie.)
a

I

look forward To our working fogefher in Prague.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry
Mszp

w

-

“luv-«.m- urn-.m-

mawwu-M'v

*1

�</text>
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                <elementTextContainer>
                  <elementText elementTextId="106241">
                    <text>April 17, 1971
Dr. Stephen Bernstein, M.D.
ECDEUwFRB

NIEh\

Chevy Chase, Maryland

Dear

Steve,

I would be most pleased to present a summary of the
present status of the EEG progile analysis study program,
with a focus on the application to ECDEU missions.
As I will be attending the conference, you
the presentation to suit your program needs.

will put

may

schedule

I do not have a formal presentation worked out, but
one together and send you a copy before the meeting.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

mf/

WW

-

n
xv

-m'r“~"'ﬁw"m:~t’w.v

...;J

�</text>
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              <elementText elementTextId="48722">
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  <item itemId="4871" public="1" featured="0">
    <fileContainer>
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                  <elementText elementTextId="106240">
                    <text>April 17, 1971
Dr. S.
NACC

J.

80 Hanson

Brooklyn,

Mule, Ph.D.

Place
New

York

11217

Dear Sam,
Thank you, and Eenry, for thinking of me for your
volume on drug dependence, particylarly for the electrophysiology.
I am pleased to accept your invitation, with one caveat : the
data will not be novel. Our data on heroin, methadone and the
antagonists have been published; the cannabis is in press; and
I know of no new material for barbiturates, cocaine, LSD, etc.

If you still wish it, a chapter on
of Dependence " can be prepared, as
with citations.

of

Drugs

Good luck

”The

Electrophysiology

an academic review

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>Dr. U.

J. Jovanovic,

April 18, 1971

M.D.

Universitﬂts Nervenklinik u. Poliklinik

WUrzburg, west Germany
Dear Dr. Jovsnovic,

Thank you for your kind invitation to participate in the
fothhcoming symposium, The Nature of'SZeep, in Wﬂrzburg, September
23~27, 1971. I am pleased to accept your invitation to chair one of

the sessions, and believe I can

I:
II:

an.

m‘vg'V-‘g'lv‘grv‘y'l‘

(Probleme der apparativen Auswertung); and
(Anderungen 1m Schlaf-EEG unter Wirkung
von Psychopharmaka) and item 45 (Kompsration der Einwirkungen von
Schlafmittel und Psychopharmaka). I would be prepared to comment in
either session from my studies.

item

.

3'
’-‘,v“’t-,1

4:.

5

37

I can also prepare a more formal presentation for the
session in item 45, under the title:

Quantitative EEG Classification of'Psychoactive

g.

"'-1?’3W

or

Psychopharmakologie (17.

in (V), particularly items

&lt;

contribution to either:

Mkthodén and Teohnik der Uhtersuahungen,

(I), particularly

In

a-

make a

Drugs

in

Man.

I look forward to the symposium, and am honored to participate.
confident the proceedings will make a valuable contribution to
the physiology of sleep.

I

am

Good luck

!

Wenmwwwnmart

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>April 21, 1971
Dr. Neiton

Pilpcl

Department of Pharmacy
Chelsea College of Science

London, England
Dear Dr.

Pilpel:

I have read with interest your report, “Tablets are not
8 issue of new scientist.
Your focus on
drug formulation as an essential part of clinical pharmacology
has been brought home to us in one of our recent problems.

pills" in the April
Since 1955,

we

have been

interested in developing

a

narcotic

antagonist for the treat-ant of opiate dependence, and while
excellent agents are available, their duration of action is too
short for clinical practicality. We believe that a formulation
which may be effective for weeks, or even months, would be most

useful.

enclosing a copy of a report of work in progress. If
if other concerns in Britain may be able to
contribute to the study of this problem I would be pleased to
discuss it further.

I

am

your laboratory, or
Thank you

for your consideration.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HFtkt
one o

�</text>
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                    <text>April 21,

1971

Dr. R. Bruce Sloane

Temple University
Health Sciences Center
Department of Psychiatry
Philadelphia, Pennsylvania 191b0
Dear Bruce,

I would like to send you a copy of the SBP report, but it
is still in preparation. For the meanwhile, you may wish to
read the enclosed preprints of our recent studies of unilateral
ECT and a progress report of the ”MEET.
The SBP
when
copy

it

report will

be ready by May

1

is completed.

and

I will

send you a

Sincerely yours,
\

ﬂax Ylnk, M.D.

Professor of Psychiatry

HF:kt

H

£5;

�</text>
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                    <text>TO:

I.

B. Schwartz

FROM:

M.

Fink,

SUBJECT:

DATE:

April 21, l97l

M.D.

Neurology

at

Kirby Manhattan

Psychiatric Hospital

Would you arrange for Dr. Morell to visit Kirby Manhattan.
to assist in the assessment of the neurological cases and in the training
of the staff? I have asked the residents to summarize the relevant problem
cases, and these summaries are attached.
When

regarding the

he

staff

Thanks.

is prepared to visit.

arrangements?

would you ask him to

call

me

�</text>
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                    <text>April 22, 1971
New

York

Hospital

Medical Systems and Computer Services
525 East 58th

New

York,

Attn:

New

Street

York lOOZl

Mr. Roy Hjelmar

Dear Mr.

erlmar:

enclosed check in the amount of $180.00 (#l23574), was
erroneously received by us, Since the disk packs which we ordered
on P0 508852 should be paid by us.
The

You

few weeks.

should receive our check for the disk packs in the next

Thank you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>April 28,
Dr. Hans

Kosterlitz

University of Aberdeen

Fosterhill, Aberdeen, Scotland

Dear Dr.

Kosterlitz,
I look forward to joining you in Aberdeen
for the invitation.

and I again thank you
w-wrw

~

:-

”WV-Fr"

‘.~

1971

we

on

July

will discuss ”Clinical Studies of Cyclazocine

Naloxone in Opiate Dependence", and the authors are, as
Drs. Mi Fink, A. M. Freedman, R. Resnick and A. Zaks.

12—13,

and

listed,

”aw-ru—

gar—wwrwm‘mrt.

"n":

m.

A

I plan to bring my wife to Europe as well as my two
daughters, ages 13 and 15. If accommodations can be made at the
Hall of Residence, I would appreciate two rooms; if not, would
you make reservations in a hotel, two rooms, with planned arrival
the day before the conference, on Sunday July 11 ?
We

will provide

a

manuscript, according to your

instructions, before the stated date of July
Aberdeen.

1.

I look forward to the conference, and to visiting
Sincerely yours,
Max

York Medical College
Department of Psychiatry
New

Fink,

M.D.

�</text>
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                    <text>'7

W.-—.—..—.——

“rump-1

-v

n—aw—~.mmnmww_u-wn

April 28,

1971

Dr. Roberto Derbez

ﬁw‘n’w‘rﬂv‘w

Secretary—Symposia
World Congress of Psychiatry
Mexico City, Mexico

IVV-vr—lrmr

Dear Dr. Derbez,
-"'-‘H&gt;"m—W'

"
7'
"

w

Enclosed

is

an

abstract of

my

presentation before the

symposium on "EEG Correlates of Mental Disorders" during the
Vth World Congress of Psychiatry.

may—paw

I should be identified as "Professor of Psychiatry,

Director, Division of Biological Psychiatry,
College, New York City."

and
Min—erv-r-u—nw

New York

Medical

I will present my report in English and will use
conventional small slides (2x2 inches).

‘

,,

“away”,

Sincerely yours,

‘w-uv'w'rn

,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April 28,

1971

Dr. Harold Williams

Univ. Oklahoma Med. Center
Oklahoma

City,

Oklahoma

Dear Hal,

are interested in someone with the credentials
of Al Salamy, and I thank you for thinking of us.
We

present programs are focussed on the EEG and behavioral effects of opiates, their antagonists, cannabis, and a few
new psychoactive drugs. I have been interested in having someone
join us who could actively participate with psychiatrists and
psychologists, with a focus on the EEG analyses. There is just
Our

too much work for me.
We

an

IBM

now

have our systems running

well, focussed about

1800 with the usual supporting equipment.

living in

The only

caveat that should be discussed is that
is not the best choice

York at the present time
an American can make.
New

I would like to meet him. I will be at the APA in
Washington all next week but after that will be in New York.
Is he going to be East anytime soon ?
Again, thanks for thinking of us. If these notes
call (collect 212 360 7900 x245).

him, have him
My

best regards.
Sincerely yours,
Fink,
Professor

Max

M.D.

interest

�</text>
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                    <text>April 30, l97l
Dear Walt,

It wlli

helpful to

be able to place Mrs. Heldman on
The
the College payroll.
College will not risk her employment without
permission from Immigration. The say, if she is caught, she is
be

deportable.

will continue to pay her, under the guise of our "ignorance"
for
should, with your help, make every effort
to get the appropriate certificates.
We

a few months, but she

I'll

call next

Keep up

week, on

my

return

from Washington.

the good work.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>March 1, 1971
Membership Secretary
American PBychiatric Association
1700 Eighteenth Street NW
Whahington, 0.0. 20009
Dear Mbdhm,

After some consideration, I am writing to request
reinstatement of'my fellowship in the APm. I trust this is possible.
Anticipating favorable action, I am enclosing the 1971 dues.
Sincerely yours,
Mum

Fink,

M.D.

Professor of’Peychiatry

�</text>
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—

W-‘rr—w

ww-ww—wnwn—w—rw—w—v—mrw

-

M'W'

www—

March 1, 1971

Jeffrey B. Donfeld
Staff Assistant to the President

Mr.

The White House

Washington, D.C.
Dear Mr. Donfeld:

It was kind of you to take the time to encourage our research
in the narcotic antagonists, and we are most grateful. Dr. Freedman
has sent you reprints of our recent reports.
There is a need for a more intense effort to deve10p a formulation
of an antagonist effective for prolonged periods, in the order of weeks
to months. With the support of the New York State Narcotic Addiction
Control Commission, we have let one contract for such a development with
Food and Drug Research Laboratories of MaSpeth, New York. We are aware
of parallel studies by Endo Laboratories of Long Island, and by Seymour
Yolles of the University of Delaware. Considering the magnitude of the
addiction problem, perhaps more efforts could be encouraged in the hope
of a more rapid solution to this technical problem.
In support of this effort, there are two steps which your office
could consider. In the fall of 1969, we requested contract support from
the NIMH for developing a silastic vehicle and were told that the available
free funds were committed and no centract funds were available. In part,
this was related to the interpretation that available funds were designated
for methadone delivery systems. Perhaps, in the next HEW appropriation
requests, the funds considered for addiction treatment and research could
be designated for "biological therapy of Opiate dependencd'or other broad
designation, thus allowing the apprOpriate NIMH committees to support those

requests which

may

be

available.

a more direct effort, perhaps your office would be able to review
the logic of the develoPment of a long-acting antagonist, and if you found
the logic as compelling as we find it, you could bring this to the attention
of the Secretary, HEW or the Director, NIMH.
As

Again,

my

thanks for your encouragement.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

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                    <text>March 1, 1911

Dr. Henry

Brill

Pilgrim State Hospital

W.

Brentwood, New York 11717

Dear Henry,
have recently completed two reports in our ongoing marijuana
study program. Using NIMH marijuana we have elicited dose elated changes
in perfbrnance and in EEG. These observations must be reported for
We

confirmation, and we are awaiting
out these replications.

some more

concentrate

THC

to carry

as I look back at our years of studies, I recall
much
have
of the time waiting for the supplies, completing
that
spent
and
”official“ forms,
answering committee inquiries. Perhaps, in your
role on the Presidential Commission, you may do a service by inquiring
into the governmental procedures for making ”legal" and official supplies
of marijuana, THC and hashish available for researchers.
we

Incidentally,

My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>March 1, 1971
Dr. Turan M. Itil
Missouri Institute of Psychiatry
5400 Arsenal Street
St. Louis, Missouri 63139
Dear Turan,

It will be a privilege to participate in the 1971-72
of research seminars at the MIP, and have set aside February series
25, 1972
for this pregram. ECT is an exciting part of our research program
and we should have new data by

Thank yen for the
and co-workers at MIP.

that time.

invitation;

my

best regards to

my

friends

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

�</text>
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                    <text>March 1, 1971

g

Mr. Alan Morton

Contributing Editor
Business Hehk

330 West 42nd

New

Street

York, New York 10036

Dear Mr. Morton:
I

read the report, "Fighting

in Business

It states

Week

with

most of the

your readers.

Drug Addiction with Drugs"
and wish to commend your report.
clearly and should be most useful to

interest

facts

Two notes near the end of the report may be overly Optimistic.
Our studies of £-alpha—acetylmethadol fail to support the interest
of Dr. Jaffe. The drug is more complex to use then methadone and
provides no long-term solution. We have already transferred a number
of patients from methadone to cyclazocine, as Dr. Kissin suggests.
Unfortunately, again, the two compounds are incompatible and the

switch-over is

difficult.

Pregress, although slow,

is continuing,

stimulates additional interest, as I believe
to the solution of a serious problem. Thank
a well written report.

it

and

if your

you

will,

it

report
will contribute

for your interest

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszpt

and

�</text>
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                    <text>March 1, 1971

Mrs. Zahida Kissuna Nafees
1287 Madison Ave., Apt. #7
New York, New York 10028
Dear Mrs. Nafees:
I regrot that our programs do not allow us to appoint a
research fellow at this time. As I know your husband, I will
keep your record in mind and if our situation changes, I will
contact him.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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__1

uh.

,

—....

-

»

“var-”WWW." mkunww—vw—mmwum.wm~.m vm

-——

We...

m,

m.“

(I‘m-“\V—"varmm

—“

March 1, 1971

Glick Book Binding Co.
32-15 37th Avenue
Long

Island City,

Gentlemen:
we

would

like

New York
‘3

is

one volumesof EEG Clin. Neurophysiol., which
to have bound in maroon with gold letteringv,
)0 U Ill/)4.—
EEG JOURNAL
read:

Enclosed

Letteringsshould

&lt;

V01.

m

m

2930
190 ("I '1"

Vat‘L-

1G7).

ét

1”.”me

mm

Division of Biological
Psychiatry

ENWVWWWI'Umrl-(mm

NYMC

,

A

ZM‘W

you

confirming purchase order, #508605,

separately.

i;Z/j” ‘

gji

C)

///

is going mailed to

Sincerely yours,

\“”’

‘;Z»~z/"

Fink, M.D.
Professor of Psychiatry

Max

,..-—"

“WW

"mat—,mw...

�</text>
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W

T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our EEG profile
analysis studies, as the basis for any recommendations you may wish
to make in NestcheSter to IBM or other organizations.
I am

techniques are applicable to the Ocean Systems interest
in ”neurOphysiological re5ponses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

MF:kt

�</text>
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www

,

_

—.uw

p»...

-

WWW-w.- mn ”7m- mu-~~m..~-- ”w

March 1, 1971

Dr. Daniel N. Robinson

Department of Psychology

Amherst College

Amherst, Massachusetts 01002
Dear Dr. Robinson;

of you to send us your c.v. I regret that we
are not expanding our study pregrams at the present time.
Dr. E. Roy John of this Department is in charge of the
research sections of the developing mental health center. While
funding is difficult, I believe he expects to begin recruiting
in 1972. You may wish to write to him of your interest.

It

was kind

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kg

�</text>
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                    <text>March 2, 1971
Dr. Thomas Williams

National Institute of Mental Henlth
PsychOpharmacology Research Branch
5454 Wisconsin
Chevy Chase, Hnryland 20015

Dear Tom,
Under separate cover, I am sending 50 copies of
the grant application, Roychobiazogy 06 ECT: Conéeacnce.

Enclosed

is the signed original.

It is a good proposal and I am grateful for the
continued efforts of all the participants.
my

best regards.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

H!:kt

�</text>
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                    <text>March 2, 1971

Br. Seymour Weingarten

Plenum Publishing Corporation
llé Fifth Avenue
New York, ﬂew York 10011
Dear Seymour,
Thank you

for your letter and the volume, Biochemistry of
I have flipped the pages of the volume, and

Brain and Behavior.

find the text readable. There is some bleeding from the page
behind, but this can be corrected by a more opaque quality paper.
The time of production is extraordinary. Congratulations!

If we go through with an BCT conference, it will be with
Janos Macaugh aa a participant. We should consider your series,
and I would ask that you send me such descriptions of the series
on behavioral biology as may become available.
for the marijuana conference we have failed to find
the funds and now hear that the New Ybrk Academy of Sciences is
proceeding with the same idea in May.
As

In there

—

still

paychOpharmacology?

room

for another journal in biological psychiatry/
Sincerely yours,

Professor of Psychiatry

Mszt

�</text>
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                    <text>March 1, 1911

Dr. Henry

Brill

Pilgrim State Hospital

W.

Brentwood, New York 11717

Dear Henry,
We have recently completed two reports in our ongoing marijuana
study program. Using NIMH marijuana we have elicited dose elated changes
in performance and in EEG. These observations must be repsgted for

confirmation, and

we

are awaiting

out these replications.

some more

concentrate

THC

to carry

as I look back at our years of studies, I recall
have Spent much of the time waiting for the supplies, completing
”official“ forms, and answering committee inquiries. Perhaps, in your
role on the Presidential Commission, you may do a service by inquiring
into the governmental procedures for making “legal” and official supplies
of marijuana, THC and hashish available for researchers.

that

we

Incidentally,

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc .

�</text>
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                    <text>T0:

Dr. Alden Loud

Graduate School,

FROM:

Max

DATE:

March 1, 1971

NYMC

Fink, M.D.

pleased to enclose a recent summary of our BEG profile
analysis studies, as the basis for any recommendations you may wish
to make in Westchester to IBM or other organizations.
I

am

techniques are applicable to the Ocean Systems interest
in "neurophysiological responses of the primate brain...”; and to
IBM sales interest in the IBM 1800.
Our

ENCL.

Mszt

�</text>
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                    <text>u, ~,v..=;- “F...

m. V-w‘"

-—-v-

-»\v

»

"Mar

..,

ummxup‘ -. w»- ;‘

”er

2-. ~

’1‘1';a,

-

mun-

ram” .,-i.~~.um.v-..I.-aw-:aw.W7'wnrr-v_~-—---.mr.rv..‘.,

smu—wrw

.

....,........-

P'O‘F"."l‘

March 1, 1971
Dr. Daniel N. Robinson

Department of Psychology

Amherst College

Amherst, Massachusetts 01002
Dear Dr. Robinson:

It was kind of you to send us your c.v. I regret that
are not expanding our study prOgrams at the present time.

we

Dr. 5. Roy John of this Department is in charge of the
research sections of the develoPing mental health center. While
funding is difficult, I believe he expects to begin recruiting
in 1972. You may wish to write to him of your interest.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kg

«wmm mwupyrh" .

.VWV

WHY“

�</text>
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“WW5!-

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urn:

wr-wu‘rva I‘q-irer-

rwa-nw.wnx&gt;_x

~a- - w...» '&gt;~-:1~‘::Y:I'i-Ivmu..--I~Vnnw‘a-WNI

March 1, 1971
Mr. Alan Morton

Contributing Editor
Business

Wehk

330 West 42nd

New

Street

York, New York 10056

Dear Mr. Morton:
I read the report, “Fighting Drug Addiction with Drugs“
Week with interest and wish to commend your report.
Easiness
in
It states most of the facts clearly and should be most useful to

your readers.

r)“

“—112.

War

"WWW-Civt-Igz'mm'm

Wmm'

Two notes near the end of the report may be overly optimistic.
Our studies of £~alpha~acetylmethadol fail to support the interest
of Dr. Jaffe. The drug is more complex to use than methadone and
provides no long-term solution. We have already transferred a number
of patients from methadone to cyclazocine, as Dr. Kissin suggests.
Unfortunately, again, the two compounds are incompatible and the

switch-over is

difficult.

Progress, although slow, is continuing, and if your report
stimulates additional interest, as I believe it will, it will contribute
to the solution of a serious problem. Thank you for your interest and
a well written report.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

A

rq—

"r
rm

nun-r,

W

rmxm

Tww-mw-

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"mm

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'qwgs'uwwale
7

.

n;

d

'1'W—W'

-

.

.

mmmwm

March 2, 1971

Br. Seymour Weingarten

_..,,

n—a—m

Plenum Publishing Corporation
114 Fifth Avenue
New York, New York 10011
Dear Seymour,

v-zwwmrwrwrmsu—vnwp—v

9-

mw-u

.—~

2

yum-711p

w.

,1

r

Thank you for your letter and the volume, Biochemistry of
Brain and Behavior. I have flipped the pages of the volume, and
find the text readable. There is some bleeding from the page
behind, but this can be corrected by a more opaque quality paper.
The time of production is extraordinary. Congratulations!

If we go through with an ECT conference. it will be with
James McGaugh as a participant. We should consider your series,
and I would ask that you send me such descriptions of the series
on behavioral biology as may become available.
for the marijuana conference we have failed to find
the funds and now hear that the New York Academy of Sciences is
proceeding with the same idea in May.
As

Is there

—

still

psychopharmacology?

room

for another journal in biological psychiatryl,
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>g

h
g
L

March 5, 1971

Dr. Robert Petersen

Chief, Center for Studies of Narcotics
5454 wisconsin Avenue

Chevy Chase ,

8 Drug

Abuse

ﬁeryland

Dear Bob,

I am writing to bring you up to date
contract study of cannabis use in Athens.

on the

status of the

Following the renegotiation of the contract terms in the
designed the data collection phases of the study, made up the
necessary forms, and scheduled the initial data collection for March.
After sending the outline to Dr. Castes Stefania, we received no
reply for many weeks.

fall,

we

February 20, he wrote: " I wish to apologize for the
long delay in answering you. This delay is due to the fact that a new
law on narcotics has been passed and is in effects since January 10,
and all this time I have been trying to find out whether under these
On

restrictions,

any

investigation

on hashish, which

is included in this
is a very serious

law, could be carried out. This, as you understand,
problem . . ."

Dr. Stefanie concluded his letter with some suggested steps
he had undertaken to clarify the issue, and indicated that
we would be " . . . hearing from me within the next few days."

that

We

have

not, as yet, transferred

any funds for the

project,

Under these circumstances, we have no recourse but to await
a more favorable reply. Unless, there is an alternate population
in which the study could be undertaken.

I will keep you informed.

g

l
.

Sincerely yours,
Max

Fink, M.D.

Professor of Fsychiatry

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                    <text>March 5, 1971
Mrs. Edward
35

Hillside

Nutley,

New

M.

O'Neil

Avenue

Jersey 07110

Dear Mrs. O'Neil:

Unfortunately, the experimental studies described in the

newspapers are limited to Lexington, Kentucky, Baltimore, Chicago
and New Haven. Some research is in
at the University of
California Medical Center at Irvine, progress
under the direction of
Dr. Henry Elliott and Dr. John C. Kramer. I
suggest she write
to either of these men for advice. In Chicago,
the authority is
Dr. Jerome Jaffe at the University of Chicago Medical
School.

Sincerely yours,
Max

Fink, N.D.

Professor of Psychiatry

MF:kt

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w~wmvnnv

“Hr-1""-

WWW—

1

March 5, 1971
Miss Carolyn Adams
c/o 782 Hemlock Rd.
Union, New Jersey 07083

Dear Miss Adams:

investigating the central effects of substances
are not in the clinical practice of neurology (neuropsychiatry).
Your letter is detailed about your search for help, but fails to mention,
help for what. Perhaps you should see your family physician or a member
of the staff at either the New Jersey School of Medicine in Newark (try
Dr. Louria) or at Rutgers Medical School, and allow them to recommend
the consultants you may require.
While we are

of abuse,

If

you, I
perhaps

we

you wish to
will ask one
we may make

detail the history of the symptoms that trouble
oi our research staff to review the material and
a more specific recommendation.

Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>March 5, 1971
Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the
is experimental and
I know of no center near you. newspapers
The closest may be the University
of Chicago Modical School, and I suggest you write
or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman 1n the
Department of
Psychiatry.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MP

:kt

�</text>
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                    <text>i

‘31

t

41

mm... 7..

mmrvvﬂvw-mw u..." ”——

..__._‘

“WM—mm...

WWW...

"T.

.

l...

Mm,

_._..

v
...

r-'

1.,._....

..,..

Vm"v

March 5, 1971
wmpm-x-uwmwuhv-v

Dr. G. F. Blane

c/o Etabliasement Reckitt Ltd.,

3? 31,
m...

"F“,

15 Rue Ampere
91 Messy, PARIS

5'4:

”I'v—mn—T‘

Dear Dr. Blane:

Since receiving your

Amn-

ww’v-

letter,

we

have:

"-—

~v'

--

of Masosn.

w"

y-w‘vrz"

‘

Im'rz-mr'

ry-H-rl'ﬂﬂr'éﬁﬂ'v-‘W'V'wwu""ﬂ""v‘7‘m

N.Y.

our

(1)

Requested release of our funds for the animal toxicology

have a reasonable bid from Food and Drug Research of
[The release should be approved by mid~March; the study April-June;

FDA

We

filing in July.]

(2) Requested funds in our 197l~72 budget for u~snso, using
your figures as a guide. Because the price is as high or higher than
naloxone, we are not sanguine about an allocation, unless our naloxone
situation becomes critical. We did ask about supplies, and it wee useful
that we did so, since the cost difference between naloxone and
M~5050
appears to be slight.

mu

(3)

N'"m"m’x

“ovulﬂgﬂwul‘

w-I:

aw

mew-5'33"

:Mgmvw-rr-wrwan

non—committal

have written to Dr. Jack Danton and received a friendly

reply.

Based on these data, we will possibly go on with the M~5050 toxicology;
and request a small supply for human study by the parenteral route.

Incidentally, we recently received 6 kilograms naloxone for our chronic
oral studies, and these are in the data collection phase.
The article appeared in Buéincaa week. A copy is enclosed.
Many

.
.

new."

We

thanks for your interest

and

cooperation.

Sincerely youra,
Fink, M.D.
Professor of Psychiatry

max

Mszt

�</text>
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                    <text>March 5, 1971
Dr. Jack Freund
Robins Company
1407 Cummings
Richmond, Virginia

A. H.

Dear Jack,
have been very interested in the use of narcotic antagonists
in treating opiate dependence, and since 1966 have carried out clinical
studies with cyclazocine, naloxone, methadone, and £~alpha~acetylnethadol.
Last fall I was asked to summarize our data, and in conclusion, I
attempted a justification of the logic of the need for a long-acting
formulation of an antagonist.
We

I believe that the methadone maintenance ”solution” to opiate
dependence is politically expedient but not a long~term solution. I
am concerned with the question of, "After a patient is on methadone,

what next?”

"Is he committed for life?"

The antagonist model is theoretically elegant and clinically feasible.
are committed to continuing our studies, have contracted with Food and
Drug Research for some help; and would encourage others to experiment with
other antagonists and long~acting formulations.
wi
We

Incidentally. our experience with narcotic antagonists has led us to
think of antagonists to other drugs of abuse, notably alcohol: and we have
recently carried out some studies to determine the degree and duration of
alcohol antagonism of propranolol.
I trust the enclosed reprints are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                    <text>March 5, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, Massachusetts
Dear Jon,

It was kind of you to recommend our studios in marijuana
to Dr. vanPraag. I am.tak1ng the liberty of enclosing summaries
of our recent reports for your information.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>.‘Rv—

Nu-‘rv.-'-'

w

“fi—u-wrx

'v-r:

-.,-.1wm—u.-.vm-—-vuxm-..n-ww...

—

r'rm

wwwmy~wwnwmp

IV

V

V'-w7-.'

'Wur’dmmu‘lr-ﬁ

*'-'-¢'-w~- .~~-—‘M.

q‘m mm...“— y..."

~..-.....

r," NWT... 7...”.

.—

March 5, 1971

Earl Ubell
Science Editor

Mr.

WCBS~TV
New York, New

Dear

York

Earl,
The TH

center in

New

York

is at

277 West End Avenue.

One

teacher
give some insight is Kip Cohen, manager of the
Fillmore East. I have no knowledge of the impact of this group
on the college scene here, but my son describes a large effect
at Colby College.
who may

My

best.
Sincerely yours,

Professor of Psychiatry

Mszt

�</text>
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                    <text>7.

”ﬂy-.w-wu—xw-v-u-

1..-

—-V

..

.&lt;

March 5, 1971
Mr. Richard

Scsrpellino

General Foods Technical Center
Tarrytown, New York
Dear Mr.

Scarpellino:

Dr. Arthur Zaks of our College has delivered 240 cc of
Narcan (naloxone) concentrate (100 mg/ml). This is to authorize

your experiments in improving the

taste of the material. We hold
the necessary federal and state authorizations for the study of
naloxone, and this request is sufficient to allow your studies on
our behalf.

We request the return of unused material and an acknowledgment
of the amount used for our research purposes.

.0...

Thank you

for your efforts.
Sincerely yours,

WWW—W‘WWWW.

WWNVIIMWW

‘I'rm’u-

WW

Hex Fink, H.D.

Professor of Psychiatry

MF:kt

cc: Walter Schulok

Michael T. McGuire

Jacob,

R. Feldman

�</text>
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                    <text>rmﬁ mtwm-ww
:a‘

yum-WV“.

_

_

,1”?

nan-umup.

.

"2““...

March 5, 1971

Prof.

H. M. van Praag

Algemeen

Provinciaal, Studs

—

En Acadenisch Ziekenhuis

Psychiatrische Kliniek

Groningen, Oostersingel 59
The

Netherllnds

Dear Professor van Praag:

participated in a number of
in
enclosing
lists ~ the participants
marijuana sessions. I
New
York
and
the
for
the
the December meeting in Puerto Rico,
program
Academy of Sciences in May 1971.
During the past few months

we

am

have

two

For human pharmacology, the names are Don Jasinshi and Harris Isbell,
Leo Hollister, Reese Jones and Roger Meyer. Ishell and Jasinski have
done the best work, published, and may not have new data. Jasinski is
a younger worker with much enthusiasm and a reasonably good speaker.
Hollister is more flamboyant, has done more varied studies, usually
with less controls. Jones is less experienced, and has done a few

studies with limited control data. Roger
but is enthusiastic and knows the data.

Meyer

is the least experienced,

For animal pharmacology of cannabis and THC, Louis Harris, Edward
Truitt and Constantine Mtras come to mind. Truitt is smooth, efficient
and very opinionated. He has unusual data. Harris is a good speaker,
excellent pharmacologiat and widely experienced. He has done extensive
studies in the narcotic antagonists. Hires (Greece), is a very flamboyant,

egocentric, hypomanic experimenter. He grows his own plants: extracts;
radiates; and does extensive pharmacology and toxicology, mostly uncontrolled.
For chemistry, the names are ﬁechoulam, Korte (Germany) and Mirna
(Greece). The other names are Pars and Wall - both recent experimenters.
Mechoulam has the best reputation, but I have never heard him. I like

his written

work.

I do not

know

the others.

For sociological aspects, I would agree with Cole, that the obvious
choice is McGlothlin. I would add Goode and Brotman for your consideration.

�Prof. van Praag

March 5, 1971

~2~

For neurophysiology, there

is little

and the choice

R. Jones has evoked potential data; E. Rodin (Lafayette
and E. Domino have published some EEG data, but have no
and our laboratory has done some work.
may

If I

were to recommend speakers

who

is restricted.

Clinic, Detroit)
recent material;

have a broad experience, which
and about whom I know

suit your purposes (as I understand them),

something, I would
Donald

Leo

list:

or Harris Isbell

Jasinaki

Hollister

Louis Harris
Raphael ﬁechoulam
Wm. McGlothlin

or Edward Truitt
or Constantine Hires
or Eric Coode

laboratory, I

would be pleased to report on our EEG studies;
memory and task performance, and describe our
trials of chronic marijuana use. If you wish a specific neurophysiology
review, you may consider Dr. Jan Volavka of my staff, who has supervised
all the records and read all the reports.

From my own

relate these to changes in

Salemink of Utrecht visited my laboratory
His knowledge of the chemistry of cannabis was impressive
wish his opinion or participation.

Incidentally, Professor

last year.

and you may

The Chief

of the

Dr. Robert Petersen,

NINE

Center for Studies of Narcotic Drug Abuse,

is the principal officer supervising the national

effort in cannabis research.

He

the Congress from the Secretary,

recently formulated the report to

DREW ~

"Marihuana and Health" (dated

January 31, 1971). This report is balanced, and thorough, is more
succinct than earlier statements, and includes descriptions of ongoing
research. It may be useful to invite his opinion about U.S. investigators;
and, to consider inviting him to present a report of the ongoing research,
results and programs, to supplement your other sneakers.
In trying to be responsive, I find that I was lengthy. Please accept
these notes as a contribution to the development of a satisfactory program.
my best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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                  <elementText elementTextId="106210">
                    <text>March 5, 1971
Miss Carolyn Adams
c/o 782 Hemlock Rd.
Union, New Jersey 07083
Dear Miss Adams:

the central effects of substances
clinical practice of neurology (neuropsychiatry).

we are investigating
we are not in the

While

of abuse,

letter is detailed about your search for help, but fails to mention,
help for what. Perhaps you should see your family physician or a member
of the staff at either the New Jersey School of Medicine in Newark (try
Dr. Louria) or at Rutgers Medical School, and allow them to recommend
the consultants you may require.

Your

If you wish to detail the history of the symptoms that trouble
you, I will ask one oﬁ our research staff to review the material and
perhaps we may make a more specific recommendation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>March 5, 1971

E

s

E

‘1Wr"mm*’“’m“‘"'7'

an

Mr. Norman L. Jackson
531 Evergreen Ave.

Dayton, Ohio 45407

Dear Mr. Jackson:
The work described in the newspapers is experimental and
I know of no center near you. The closest may be the University
of Chicago Medical School, and I suggest you write or visit
Dr. Jerome Jaffe or Dr. Daniel Freedman in the Department of
Psychiatry.

Sincerely yours,

pmww—vw'uwrrw'

Fink, M.D.
Professor of Psychiatry

Max

”wwwqy‘xwmm’rm

W

.
v

M,

rm...-

my

.r'w'

V

Mszt

�</text>
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                    <text>.

.

ww—

,

,

“I‘m‘,._ a"
.

,.

.

.

w 1-

.--

,,

"nu—m..... ”New

r.

,.,.V

Hitch 5,

1971

Mrs. Edward M. O'Neil
35 Hillside Avenue
Nutley, New Jersey 07110
Dear Mrs. O'Neil:

Unfortunately, the experimental studies described

in the
newspapers are limited to Lexington, Kentucky, Baltimore,
Chicago
'and New Haven. Some research
in progress at the University of
is
California Medical Center at
under the direction of
Dr. Henry Elliott and Dr. JohnIrvine,
C. Kramer. I
suggest she write
to either of these men for advice. In Chicago.
the authority is
Dr. Jerome Jaffe at the University of
Chicago Medical School.
Sincerely yours,
Max

Fink, %.D.

Professor of Psychiatry
MF:kt

'w'

"m"

W‘

""""‘"

r-ww-Wm'$"""'PF

‘&lt;-‘-'

T"

wn'm'rw“

.
Kn.

{ur‘arrrj

g_

'"H‘ﬁ'

WWW-r

w

m.“ m
.-

.-

W...ww.ku-—

�</text>
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                    <text>E

:5

E

Hitch 8,

E

g
,i
E

r

1971

Dr. Jerome Levine

National Institute of Mental Health

Psychopharmacology Research Branch
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear

Jerry,

ww-«w

year of MH~13358 officially ends March 31, 1971.
February 1, I requested an extension of the budget period.
copy of that letter is enclosed.
The ~04

On
A

I would be most grateful for a reply, as the school's
budgeting procedures preclude expenditures against this grant
after March 31, unless it is officially extended.
Thank you

for your cooperation.
Sincerely yours,
Bax Fink ,

.‘ft

o

Do

Professor of Psychiatry

MF:kt

�</text>
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                    <text>Heron 8, 1971

Dr. James McGaugh
Department of Psychobiology
University of California at Irvine

Irvine, California

92664

Dear Jim,
The application for a conference on the psychobiology of
has been completed, and I am enclosing a copy. Your suggestions
were most helpful, and have been recommended almost in their entirety.
ECT

Williams believes he can get the application before the
appropriate committee in April.
Tom

Seymour Weingarten of Plenum wrote of your new publication
and asked about publishing this conference. I asked that
he send whatever descriptions he develops so that we can make a
decision. Good luck on the series!

series

My

thanks for your help.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Mszt
enc .

�</text>
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                    <text>March 8, 1971
Dr. Seymour 5. Katy

Department of Psychiatry
Massachusetts General Hospital

Fruit Street

Boston, Massachusetts 02114
Dear Seymour,

I very much regret not making the LaJolla meeting, but I
ill with influenza the day before I was scheduled to leave
for California, and spent an unprofitable week in bed.

became

Your notes were most helpful, and with the changes recommended
by Jim McGaugh and Tom Williams, yielded the enclosed program for
before the appropriate
an BOT meeting. Tom believes he can get

it

committee in April.
Many

thanks for your suggestions, and

my

very best regards.

Sincerely youre,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

enc .

�</text>
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                    <text>March 8. 1971
Dr. Edward L. Platcow, Ph.D.
Department of Drugs
American Medical Association
535 North Dearborn

Illinois

Chicago,

Street

60610

Dear Dr. Platcow:
As

requested, I have read proposed chapter

It is well written

are few.

and

authoritative,

32

"Antidepressants".

and my comments and suggestions

Pg. 32$) Paragraph 1: Recent notes suggest that thiothixene
(Havana) also has antidepressant qualities. We demonstrated such
is my impression that Drs. Norman
activity in our studies, and
Pitts and Allen Borger at Pfizer Laboratories, Groton, Connecticut

it

can provide the available documentation.

Paragraph 3. The role of ECT is presented in too limited a
fashion. In every study of ECT and antidepressants, ECT is more
effective and more rapidly (see Cole and Davis, in Freedman and Kaplan,
"Comprehensive Textbook of Psychiatry“, 1967: 1263—1275; Klein and
Davis. Diagnosis and Treatment of Psychiatric Disorders, 1969: 187~322).

important, in suicidal risks, involutional melancholia, and
psychotic agitated depressives, ECT may he 1ife«saving, while antidepressants are too slow and ineffective. Although drug evaluation
is the focus, in my view, ECT is a complex way to achieve a biochemical
change in the CNS ~ which is, after all, the goal of pharmacotherapy.
Most

Paragraph

Too harsh an evaluation. The
show many controlled studies.

&amp;.

Klein and Davis

Paragraph 5.

depressions.

A

references cited by

reason to emphasize the value of

ECT

in severe

Pg. 259, Paragraph 1: English syntax is poor in phrase, ”..., since
these agents block the actions of these antihypertensive agents".

Paragraph 3. The duration of drug effects is generally 48~72 hours.
The recommendation of a 2~week interval between tricyclic compounds and
MAUI seems much too harsh, and too restrictive.
Probably 72 hours are

adequate.

�y‘)

Dr. Platcow

March 8, 1971

—2~

Paragraph 9. I do not know the evidence for restricting
imipramine in epileptice. My own data suggests it may reduce seizure

activity in the brain,

and may

therefore

be recommended.

the data source be checked (see Canad. Peychiat. Assn.

166-171, 1959).
A

J.,

I suggest

6(Suppl.):

restriction omitted is the use of imipremine in schizophrenia,

where excitement states may be precipitated
Plenum Press, 1965, 1; 53-61).

(in Biological Psychiatry,

Pg. 260, Paragraph 2.

Same as ?age 259, Paragraph 9.

Pg. 261, Paragraph 1.

Sinequan

is

now

prepared as a concentrate also.

Pg. 262: Nialamide, and Phenelzine: Efficacy is suggested in
endogenous depressions. The evidence is clearly that such patients
show no response to HAOI, and if there is any application, it could
be in the neurotic depressives.

Tranylcypromine. Same as for phenelzine. Surely, there
that tranylcypromine has been effective over ECT. I
is
would doubt that there are cases ”inapprOpriate for ECT” [such as?) who
may respond to tranylcypromine.
Pg. 263:

no evidence

I trust these

comments

are helpful.
Sincerely yours,
Fink, K.D.
Professor of Psychiatry

Wax

MF:kt

V

.ww‘ﬁw

~v—w.

:‘.’l.‘,‘

WWW”

93¢)Wmm-

Wit-5.

"at

wa-MW

�</text>
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                    <text>pram-www—

~xW-r-

.mwmwry'l‘

:
:‘r-v-c

mvv—‘vvy'w‘

March 8, 1971

,.,

,wr:v—2

.

_Wn&gt;mﬁrm-ﬂ"

—m

Dr. William Martin

Addiction Research Center
National Institute of Mental Health
Lexington, Kentucky

r..-,—&lt;.,—q

,—

vmzme’r‘wmwv-W‘

f

wry-""5

~—~

:
g—

.—

Dear

I

Bill,
for the report on
that further studies will

Thank you

hOpe

1639. It is
be encouraged.
EN

quite clear

and

Last week I appeared before a New York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur; and that tolerant subjects
were completely ”normal".

.mrwwr—r-w

.

In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
seem

cited abate?
Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>VFVV.W75'.-r——

:w’mn'rvww-m

,

.nm

march 8, 1971

Dr. William Martin
Addiction Research Center

National Institute of MBntal Health
Lexington, Kentucky
Dear 3111 ,

I

Thank you for the report on EN 1639. It is
hope that further studies will be encouraged.

quite clear

and

Last week I appeared before a ﬂew York State legislative
committee investigating our methadone programs, and heard a
report that methadone was safer than cigarette smoking; that
euphoria and sedation did not occur: and that tolerant subjects
were completely "normal”.
In your report in October to the Methadone Conference, I
to recall that you found methadone and morphine to have
very similar physiological effects, including measures of euphoria.
If a preprint of that report is available, I would appreciate a
copy; and, would you allow a copy to be sent to the committee
cited abate?
seem

Many

thanks.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Hex

MF:kt

�</text>
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"'17—.

.. y“

.

,

~

.‘r-p- vna‘ yaw-u

;

’wr!¢wﬁmm‘rv—v.—~~

H'v

u»

,

mmlm"

p

)mrmlwmww‘w.

71m..- r.“ m.‘ ”Jr-wan.»

{\
Q)?

March 10, 1971

Miss Linda Davidhoff

Veterans Administration
Mental Hygiene Clinic
803 S. Salina Street

Syracuse,

New York 13202

Dear Miss Davidhoff:

RE:

670-116A

Your request for help was received. There has been no
further study of lactate or propranolol here, and I have read
no recent reports.
For your patient, the use of thioridazine is to be
questioned since it has adverse effects on cardiac function.

Perhaps your consultant would consider a trial of ECT, or
doxepin - the latter being the most recent anti-anxiety agent
to be made available.
I

recommend

regret that

I do not accept referrals, but could
physicians in this department, should you wish to

have your patient seen in

New

York.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:kt

r

.v;~

r- --—\

v «raw—r
v

�</text>
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""‘

" "~""" "“""

.,,.,....w_

r

v

hard.

10, 1971

Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

WW."

Wu

-

1014 Hoe Avenue
Bronx, New York 10459

._.

a.

-—-‘-

"ﬁr...

..

mu.-

v—

.wa—

Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.

‘rnwe—

Good luck

..

in your efforts.
Sincerely yours ,

wwwprx..-‘

nan-p

"a."

Fink, M.D.
Professor of Psychiatry

Max
-w.yw&lt;.4-w~—N-1~:nq—u

-.—-

Mszt

y-

"quay“.

mum

«puma.

urw-Wm-

arr-"w-uvm-me-nwmy—a

ws-v

mem~w~wwunWW-rvv,avwvuww

831C.

\

r:

‘mv we...

�</text>
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\l—I“F7ww1\ ..-.‘

V»

..

w...

m

March 10, 1971

”3-w-

*-u'vrtv_4

vw-r—v:w,n-:gw~w~

Dr. Jay F. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in Opiate addiction.

Sincerely yours,
Max

Fink, “.0.

Professor of Psychiatry

MF:kt
GDC .

�</text>
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                    <text>March 10, 1971

Dr. Hans

W.

Kosterlitz

Department of Therapeutics and
Pharmacology

University of Aberdeen
University Medical Building

Foresterhill,

Scotland
Dear Dr.

Aberdeen

Kosterlitz:

Our contribution to the ”Symposium on Agonist and Antagonist
Actions of Narcotic Analgesic Drugs” in Aberdeen will be:

Clinical Studies of Cyclazocine

and Naloxone

in Treating Opiate Dependence

Max Fink, M.D.*, Alfred Freedman, M.D.,
Richard Resnick, M.D. and Arthur Zaks, M.D.

I
I

trust we will be able to obtain the funds
will write again.
The program

participating.

You

and

if we

are unsuccessful 9

is an excellent one, and we look forward to
will recommend hotel accommodations when

arrangements are made.

Again, our thanks for the

invitation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt
"0'"va

«an:

w

‘

cc:

Dr. Freedman

�</text>
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                    <text>March 10, 1971

Dr. Jay P. Kirkpatrick
Division of Science and Mathematics
Eastern Montana College

Billings,

Montana 59101

Dear Dr. Kirkpatrick:
The address

that of the Federal

of

FADA

is

36 West 34th St., New York, New York;
is 5600 Fischers Lane, Rockville,

Bureau of Drugs

Maryland 20852. Enclosed is a report from Science which summarizes
our knowledge of the antagonists in opiate addiction.

Sincerely yours,
Max

Fink ,

M.D .

Professor of Psychiatry

Mszt
enc.

�</text>
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v-ukV—nF‘W‘r'ﬁw-v'wva- a
»

-

~

‘-m-‘w‘wgw—Hun'v'.‘.:«-—,V" v ‘-

I-M'mxﬂ:

r
w,”

m'm

w.,

i
..-;xwmw—
mmwvwﬁ.-.vm—W.-.vw
,

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-

“my”. xrr—rF-

-..

i...» .ww—nnq~-~vmv'vrw:s&lt;"wx"'ls—

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March 10, 1971

“......"

V

"wan—"Mr

v“

..V.

,

Dr. Ali Keskiner

Missouri

Institute of Psychiatry
Street

5400 Arsenal

St. Louis, Missouri 63159

vmnr'vw'w‘

“TVA‘V'W-wv'm-r-U-Wmmrvmrwmmu’r

Dear Ali,
Enclosed is a copy of the text of the exhibit in Anaheim.
There should be available printed copies of this text, as well as
a notebook for requests for reprints. The actual reprint from which
this data was taken is the report that appeared in Compliehensive

of which is enclosed.
will tell you, he is taking

Paganini/Ly, a copy
As Don

you
me

my

place because he would
I will not meet

in California. I am sorry
this time, but look forward to seeing you soon.

like to spend a
and

Please

I

My

few dwgs

a statement of your expenses and send them to
will see that you are fully reimbursed.
make up

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mas:

MP:

kt

Happy

Birthday!
Kathy

'

»~—-.

~

~

.L

‘WV‘r-‘nWI-J-n

“....

�</text>
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                    <text>March 10, 1971

Dr. Max Streifler
Head, Department of Neurology
Municipal Governmental Medical Center

Ichllov Hospital
Tel-Aviv, Israel
Dear Max,

Your kind invitation to attend the conference on prolonged
drug usage and the fetus was most welcome. I would like to attend,
as the problem is a critical one. My laboratory, however, has no
data on this Iroblem and we will be unable to contribute to the

proceedings.

may, however, be able to send an observer, and I would
appreciate a capy of the definitive program when it is available.
We

profiles of psychoactive drugs have been successful
in classifying some new drugs (thiothixene, cyclazocine, doxepin),
Our

EEG

in showing the bioavailability and equivalence of two dosage
forms of doxepin, and of the capsule and concentrate thiothixene.
We are now studying some new, numbered drugs and believe the
technique will have more general applications.

In addiction research, we are the principal agency studying
the narcotic antagonists (cyclazocine and naloxone) for Opiate
dependence; and, because of our local concern, the neurOphysiology
of cannabis.

It is

a busy time, and

if

I can reach Israel in September,
I look forward to seeing you

I will try to audit the sessions.

again.

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>-

‘

W""""'~&lt;‘~~-...~..v.",--

&gt;'v:'

v.5.

.~

{

.m

._

.

WV , -“ , ~

-

,

-~.-—»—

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..
,

"A,

may

w—p—w n...“

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v

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a. ,_

,

.

M—.m——-u:.:mv-V:,,.....,..

m

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“ﬁrm—‘1

a

Mardh 10, 1971

Miss Linda Davidhoff
°

i

Veterans Administration
Mental Hygiene Clinic
803 S. Saline Street

Syracuse,

New

York 13202
ma;

Dear Miss Davidhoff:
E

670-116A

no
for help was received. There has beenread
have
I
and
further study of lactate or prepranolol here,
no recent reports.
For your patient, the use of thieridazine is to be
function.
questioned since it has adverse effects on cardiac
Your request

ECT, or
Perhaps your consultant would consider a trial of
agent
anti-anxiety
doxepin - the latter being the most recent

to

be made
I

recommend

available.

regret that

I do not accept

referrals, but could

physicians in this department, should you wish to

have your patient seen in

New

York.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

3

Mszt

in,~e- mm "0 ’«W‘xw- »m.
.,

,

.,.~ ,

.1

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H. v

�</text>
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                  <elementText elementTextId="106200">
                    <text>.M. w—w.V.r,.m«.._-wTr»-..

W’H-r‘w'hwv mu m ”EV-"h“‘mm
.

um ".vk‘wrv' V‘W‘1Wllrr'U-v:

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,WW

,

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w-u

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March 10, 1971
Mr. Richard Mattaschiam

Assistant Coordinator

of Research and Communications
Service for Education &amp; Rehabilitation

in Addiction

1014 Hoe Avenue
Bronx, New York 10450

Dear Mr. Mattaschiam:
I am enclosing a copy of a recent summary of our experimental
work with the narcotic antagonists. The work is still experimental
and not applicable to the general treatment programs.
Good luck

in your efforts.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Mszt
8316.

-

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                    <text>r

v.7.‘wvmmr-

m .‘u- mm v

,

».

.--a———yw.~..-..»;..,~_.ma: w.-m—w:mw.umw.w~xm

me-

“r‘WWhﬁmvww-ms-m&lt;ww'wnrw~

»

——v--

,

V

March 10, 1971
Miss Loretta C. Kelly

Director of Sales

The Castle Harbour
Bermuda

Dear Miss Kelly,

are interested in a meeting this fall, but our
committees
will not meet until late April. We have
planning
received your descriptions and these will be considered at
We

that time.

Sincerely yours,

E

E

E

Fink, M.D.
Executive Director
Max

g

2

g

:

.

w

.,—

—mmwmuu~m

‘wv-wu—vzv... mm

Mszt

m A...“ ,

y

w I‘M-Iv

u"

�</text>
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                    <text>March 12, 1971
Dr. Charles Shagass

Eastern Pennsylvania Psychiatric

Institute

Philadelphia, Pennsylvania 19129
Dear Charlie,
We

have checked the

called Fritz Freyhan,

who

files for

By-Laws. We found none and
had
he
said
no knowledge of By-Laws.

If we are to follow precedent. an increase in the dues would
require Council action, followed by approval by the membership at
the next annual meeting.

You may wish to suggest appointment of a constitutional
committee which could formulate By—Lawe of a more general nature.

For the past few meetings of Council, chairmen of various
committees have been invited to the meetings. Fritz reminded me
that these men are not officially part of Council. As the meeting
broke up, Ron Fieve asked me if he was a member of Council and,
if so, should his name not appear on the stationery. I would
suggest that this is another "constitutional" question which could
be referred to a committee and be made either as a modification of

the constitution or part of the

By~Lewa.

Sincerely yours,
Fink, M.D.
Vice-President

Hex

MF:kt

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                    <text>nag;

“w”,

a

Hatch 12, 1971
Dr. Israel Kesselbrenner
Kirby Manhattan Psychiatric Hospital
Ward's Island
New York, ﬂew York 10035
Dear Res,

while I know you have notes of the various topics discussed,
I should like to summarize our meeting.
the

Over the next few weeks I would like to meet with members of
staff and gradually introduce the new members coming from the

Department.

As I understand it. parking is no problem; cards for meals in
the main dining room will be made available to those who are on the
State payroll; a clerk secretary will be designated as a liaison for
those of us from the College; and the following personnel will be
put on the State payroll effective March 1: Fink, Gaztenaga,

ibrhiéahli, Durbin,

Abrams .

With regard to offices, I will try to negotiate the use of one
of the examination rooms for a laboratory; and you have made three
rooms available. It is my expectation that as soon as I understand
the various rules of the staff, I will request reallocation of space
using these three rooms as the basis for "musical chairs". I anticipate
that you will make a suitable office available for my use this uehk.
If possible, I unuld appreciate your requesting a direct telephone line

to this office.
Thank you

for your cooperation.Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

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3. Stewart
Administrator
Sydney City ﬁospital
Sydney, Nova Scotia

Mr. H.

Dear Mr‘ Stewart:

resident in training at the Missouri
or 196A. During his tenure he
of the effects of high dose LSD
in
a
study
participated actively
of
co~outhor
and
our peport on "Prolonged Adverse
was
in psychotic:
LSD
published in 1966. He
Subjects",
in
Reactions to
Psychotic
Dr. Waheedul Hague was 1

Institute of Psychiatry in

left

1963

after completing this study.
I recall, he was reliable, interested in his work,

soon

As

participated actively in our program.

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

MFhkt

and

�</text>
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....,

.._. 7.,

.w

.

"W"

my W.

.-.».,¢....1,..W.

..-i._,..gzﬂ-mi.. 7...": ,v‘.. “n.-.

q

.pvwwwmc

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,

...

.-

r

-

--‘rn.' .,

,

www—

~.—--

_,,.._

“it my .. .,....1

,‘
v."

m

March 15, 1971

—._.,,~._.....wr-A.

.hwrwn...“

American Association for the
Advancement of Science
1515 Hasaachusetts Awe., N.w.
Washington, 3.0. 20005

m-....,.«_'

”my?”

wm—wuwwwmw

w“

Gentlemen:

I am writing with regard to invoice M74709f for 500 reprints
of ”Narcotic Antagonists in Opiate Dependence”, in September 4, 1970.
The invoicc is for $90.00.
According to our records, the reprint request was submitted in
July and at that time the estimate was $36.00.
would appreciate your checking your records
the invoice.
for
basis

I

and

verifying the

Sincerely yours,

WW&lt;

u’hwvvrﬁov

Max

Pink. M.D.

Professor of Psychiatry

Mr:kt

�</text>
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x.

w“...‘wv—. fwwv.’vw’inn-wrpgw. r-‘nvmm—

_

.

_

.w. :J»vl
“a“.wn—ﬁw:.‘-~v-mw.-._.—v-~....—w—w

VrIVw-mem’"

—--o«

March 17, 1971

Corporation
c/o Data~Rep Associates Inc.
Ampex

P. O. Box 164
Huntington Station,

Attention:
Dear

New

York 11746

Mr. E. P. Nelson

Sir:

Since delivery of the magnetic tapes, ordered February 23,
has been delayed beyond a reasonable length of time, I am hereby

cancelling the order.

Sincerely yours,
~16"

,

Max

MF:kt

.,

t
‘_

,1

.

.
..

..~

«1:;

urn-mn-l-R'VFLIIWJW‘H'w-.-‘1'$

"1",

”now-mu-

Fink,

M.D.

Executive Director

-y..-“-v.ww».

~u-cm:~usu-~u~vw

�</text>
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                    <text>March 17, 1971

Dr. Theodore D. Langley
Research Neurophysi‘ ogist
Ocean Systess, Ines

Tarrytovn Technical waster
Tarrytown,

New

York £0591

Dear Dr. Landlay:
The dean of our graduate school,¥Dr. Tabachnik sent us a capy
of the biographical sketches of Ocean Systems employees. The note,
that you are developing "a computerised systes for recording and
analyzing brain waves" interested me. Two units of this Department
are actively involved in such work. '

interest is in_relating changes in the background
EEG to dose, type and duration of
drug
adninistration.‘ Our system is based on an IBMJIBOO control computer.
Our own

alert (or sleeping)

report is enclosed.
Dr. E. Roy John, also in this Department, analyses the responses
evoked to repetitive stimuli, and uses the PDP—lz.
A

copy of a recent

If either system may be related to your work, or that of Ocean
Systems, I would be pleased to hear from you.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

M?:kt

cc:

A. M. Freedman

Dr. Tabachnik

�</text>
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                    <text>Hatch 18, 1971
Dr. Ibrahim S. Turak
Maryland Psychiatric Research Center
Box 3235

Baltimore, Maryland 21228
Dear Dr. Turek,

will

We

be

have many

reprints, beginning in 1953.
relevant to your studies are enclosed.

Good

The ones

that

luck!
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

HF:kt

�</text>
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                    <text>:m ymr—m

F—zmrw—uw
W1"

_.-,...—

:

v

.

-

.. , ya m ..x..,

W

,4 . » ‘

mm

,

.r .

--

,

,

.

.

mnxm..y..u.~v—w.wmxwv
,

.

mm‘wmrnv—pupmr

March 19, 1971
K.

E. Page, Dept. Dir.

Jails

Prisons Div.
Office of the Sheriff
Consolidated City of Jacksonville
P. 0. Box 2070
Jacksonville, Florida 32202
&amp;

Dear Mr. Page:
We can accommodate your kind invitation to
present our
work at the F.C.C.D. Conference on June 24, 10:30 e.m. to 11:45 a.m.,
in Hollywood, Florida. I believe that I may be able to attend, but
if I cannot, Dr. Richard Resnick, Assistant Professor in our Department,

will present our report.

Narcotic Antagonists: A Rationel Approach
to Opiate Dependence
The authors, if you wish to list them, are Mex Fink, M.D., Alfred
Freedman, M.D., Richard Resnick, M.D. and Arthur Zeke, M.D.

Again, our thanks for the

invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

Hszj

M.

«x.

r

m

�</text>
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                    <text>Batch 19, 1971
Dr. Jonathan 0. Cole

Superintendent
State Hospital

Boaton

Boston, Massachusetts
Dear Jon,

Peter Irwin and Nick Pavel visited 383 on Tuesday. They
reviewed the recording methods and recalibrated the equipment,
so that other records will be analyzable with ease.
Enclosed are the transportation stubs.
If not, will cover with our funds.

thanks.

my

If payable,

many

best regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

MFA“:

one .

�</text>
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                    <text>March 22, 1971
Mr. Warren K. Snoot

Aeaietant Attorney General
Criminal Justice Division
188

W.

Randolph

Chicago,

Street (Suite

Illinois

60601

2200)

Deer Mr. Snoot:
NINE

The most

definitive source of date

on marijuana

is the recent

report, "Marijuana end Health", dated January 31, 1971.

studies are devoted to the effects of marijuana on brain
A summery of our latest study data, and a
"position paper” are enclosed. Our contract, for studies in Greece,
1a in progreee but no data are available now.
Our

neurophysiology.

If

you have more

our aaaistance.

specific questions

we

will be glad to offer

Sincerely yours,
Fink, M.D.
Executive Director

Max

Hr:kt

�</text>
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                    <text>March 22, 1971

J.

Mandela
V.A.
Hoepital
c/o
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Dr.

Dear

Joe,

a revised chapter, "The Electroencephalogran in
Clinical Psychiatry". Your comments were cogent, and I trust I
made the changes in a useful fashion.
Enclosed

(3)

but this

is

has been revised. It has been published elsewhere,
sinplified version can be published.
Table

1

controversial sections on pages 9 and 10 are indeleted.
a
These are useful for the specialist, but may have no place
(11)

The

textbook.

Unfortunately, there is no good data on the effects of
or PCPA on the EEG, and these must be obtained.

(14)

£~Dopa

Thanks again

for the excellent editing.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Hutch 22, 1971
Mr. C. C. Elsoooor

Research.ﬂonogor

Jollo Division

Gonorol Foods Corporotion
White Plains, Now York
Door Mr. Elooooor;

In rogord to tho ooovorootion I had with Mr. Fox on Wodnoodoy,
I would liko to clarify tho oituotion rogordios
noloaono. ﬁr. Fox.woo opprohoooivo about tho Gonorol Food. Corporation
having noloxono in its pooooooioo since noloxono io officially listed
on o Class A narcotic.

March 17, 1971.

0:: march 17, 1971, I contootod Mr. Cootorollo, (212 349-8030)
Chiof of tho Buroou of Norootioo and Dangerous Drugs of tho Justico
Boportoont for tho Row York aroo. Mr. Cootorello was infornod of tho
situation oad ototod thoro would be no difficulty in tho Gonorol Foodo
Corporotion.ho~ing noloxono in its pooooooioo. ﬁo ototod thot tho
corporotion would ho ooting oo tho ogont of tho Dopartmt of Poydxiotry
of tho Nov York Modiool Collogo.

This is an unusual oituotion bocoooo noloxono is not o narcotic
in tho phornooologio oonoo. It has no obuoo potontiol, and has no
rooolo voluo. Tho Juotioo Doportnont, roprooontod by Hr. Contorollo,
in perfectly ouoro of tho oitootion, oud boo given aoouronco thot thoro
will ho no logol prohlon on for on tho corporotion pooooooing thin ogont.
In fact, tho Horootic Addiction Control Commission, tho ﬂotionol Inotitoto
of ﬂoatol Bonito ond tho Jootioo Bogggtooot oro ooncornod about olploring
tho uoo of narcotic ontogooioto in ti? trootoont of opioto doponoonoo.
Ho. along with thooo osonoioo, would be ooot opprooiotivo if you would
noko ovoiloblo your toohnicol okill in making this drug polotoblo.
Thio rooooroh io oupportod by tho notioool lootituto of Hontol
MH-18172 and tho Hon York Stoto Horootic Addiction
Control Con-iooion, Controot No. Gb‘llG. Tho Now York Medical Collogo
boldo o narcotic rogiotry l£2291 Clooo Q 5 5.

aoolth, Grout lo.

�Mr. Elana-or

Match 22. 1971

~2~

It 1. booauoo of tho rapidly inoroaatng problem of narcotic
addiction that roooaroh in this oroa has bacon. iaparazivo. Tho
technical koovladgo of your company would ha a vain-bl. oarvioa to
tho community. It would allow rooaaxoh to progrooa to on. of tho
proaiaing awanuoa of traataoot of this urgent public haalth problom.
Ho

hope to hear tron you ohortly in

this matter.

Sincoraly yours,
Fink, K.D.
Protooaor o! Poyohiotry

Max

Arthur

H. Zako, M.D.

Instructor in Psychiatry

H3:kt

cc: ﬁr. R.
Law

Y. Fax

Dopartaont

�</text>
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                    <text>T
“WVNW

wmw.mwy“m

“m

v-

v—v-

March 22, 1971

Acta Paych. Scandinavica

Hunkagaard

Praga Boulavard 47
2300 Copanhaaau

8.,

Denmark

Gantleman:
Wa

would

lika to purchase copiea of:

Supplamant 213, by Laurell an Flurothyl
Supplamant 215. by D'Elia on Unilateral ECT.
Ara thaaa

availabla,

and

at what coat?

Thank you.

Sincerely youra,
Pink, M.D.
Executive Director

Max

MF:kt

�</text>
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                  <elementText elementTextId="106190">
                    <text>March 22, 1971
Dr. C. Paul Psecaross
3301 East Ocean View Avenue

Norfolk, Virginia

Dear Dr. Pascarosa:

in the study of narcotic antagonists in the
treatment of opiate dependence ere expanding, and we are inviting
clinical psychiatrists to join the program. Our training division
will make arrangements for those interested in specialized aspects
of psychiatry, so that you could obtain the exposure to clinical
problems in addiction and the psychiatric training you seek.
Our programs

support our study programs. We are unaware of any
fellowships that they have considered elsewhere.
FADA may

If

you ere

interested in a training program with emphasis

addiction, or s clinical position in addiction,
s cepy of your curriculum vitae.
A

copy of one of our recent

we

on
would appreciate

reports is enclosed.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MP:kt

�</text>
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                  <elementText elementTextId="106189">
                    <text>March 22, 1971

Dr. Bartram Schiclc
77

Burton Avnnuo

Minncapolis, Hinncsotc
Door

Burt,

WWW.

A

WI-

‘

fcw months ago

on the proton:
My

state

I completed tho enclosed technical report
of the EEG program for psychopharaccology.

best regards.
Sinccrcly yours,
Fink, M.D.
Professor of Psychiatry

Max

Mrzkt

�</text>
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          <element elementId="50">
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              <elementText elementTextId="48014">
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              <elementText elementTextId="48022">
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                    <text>Hutch 22. 1971

ﬁr.

C. C.

Elsosoor

aosoorch.ﬁanagcr

Jello Division

Gonsral Foods Corporation

Whito
Dear

Plains,

How

York

or. Elaoaoor:

In regard to the conversation I had with Mr. Fox on Wadnosday,
ﬁarch 17. 1971, I would like to clarify the situation regarding
naioxone. ﬁr. Fox was apprehensive about the Genital Foods Corporation
listed
having oaioxone in its possession since naloxonc is officially
as a Clasa A narcotic.
349~8030)
0n darch 17, 1971, I contacted Mr. Coatcrcllo, (212
Justice
the
of
Drugs
and
Dangerous
Chief of tho Bureau of Earcotics
of tho
informed
was
Mr.
Costcrello
Department for the ﬂaw York area.
Foods
General
the
in
situation and stated there would be no difficultyﬁe stated that the
Corporation having unloxonc in its possession.
of Paychiatry
corporation would be acting as the agent of the Department
of the How York Medical College.
This is an unusual situation becauso naloxono is notanda narcotic
has no
in the pharmacologic sense. It has no abuse potential,
Mr.
Cottorolio,
by
resale value. The Justice Department,andrepresented
has given aosurance that theta
is perfectly aware of the situation,
'9111 be no 10331 problem as for as the corporation possessing this agent.

the Rational Institute
In fact, the narcotic Addiction Control Commission,
about oxyloring
concerned
of mental ﬂoalth and the Juotioo Dooattmcnt are
dependence.
of
opiate
the usa of narcotic antagonists in tho treatment
you.wou1d
it
most
appreciative
Ho. along with those agencies, would be
palatcblo.
drug
make nvnilcbio your tachnicol skill in making this
annual
This roooatoh is oupportod by the Rationol Institute ofAddiction
Narcotic
York
ﬂow
Stat.
Hoolth, Grout no. MH-lﬂi?! and the
How York Hcdicol Collcgo
The
04‘116.
No.
Contract
Commission,
Control
4
a
5.
hold- a narcotic registry #62291 Class

�.

"away-T

.

.

m

77;

W‘~

“.mﬁV'VW—II‘

r-r‘no -/.»v.w' avg-«v.4:

cmrwrmwrmarwr,rx-u-m-W-wnw rr-z'wwr-

,~vr.‘..,v-M»-

“’75—34,wwvwmw—ymkum—rwv-v”:

-‘!VIN"."--v'4x~n':r'W‘hvwra

‘.;--—

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AV-- x

w «--vx..mwv--ns-&gt;.

,

«=7 - .—- «r ~vw—w

war

n.‘

gun-y

-.m.

Ji

n,

._,.

,‘1

rim—v

ﬁr. Elsasaor

~2-

March 22, 1971

Wa.',

'—w"lovv

It is becausa of the rapidly incranning problem of narcotic
addiction that raoenrch in this aroa ho: bacon: imperative. The
technical knovladse of your company would be a valuablo sorvioe to
tho community. It would allow rcnoarch to progress in one of tho
promising avunucr of rrnaruonr of this urgent public health problom.
We

hope

to hear

from you

shortly in this matter.
ﬁincercly yourl.
ﬂax Fink, M.D.

Professor of Psychiatry

Inks, Md).
Instructor in Psychiatry

Arthur
HF :kt

cc: ﬁr.

Law

vm-“V'WW'F

Ww‘mm-W

sac-71:»

tar

Pm

rat

W

:a..-wnymu

wry—mp

”Fl-:3;

'w
vl‘,

R. Y. Fox

Department

M.

wrw : m-vm-rsmv—“mn var-u»- ---

�</text>
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                    <text>-WV

.{1

,_

-v

....,...A.,,‘,

Mardh 22, 1971

Acts Psych. Scandinavica

Munksgaard

Frags Boulevard 47
2300 Copenhagen

3. ,

Denmark

Gentlemen:
We

like to purchase copies of:
Supplement 213, by Laurell on Flurothyl
Supplement 215, by D'Elia on Unilateral

would

Are

these available,

and

at

what cost?

Thank you.

Sincerely yours,
Fink, M.D.
Executive Director

Max

MF:kt

ECT.

�</text>
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                    <text>1

9

I

m»

«arm—xr‘mw‘wx-pus.mrv~w.w»-.rm'unwrmnmam

li-“iru'mr'ﬁﬂ- (v smwmmvntm‘m—wnm»,;

—~

r

“H'm‘r

"7|"!lkﬂmn‘yw

zr-v

~-

~-,—

w—m‘ :rv‘ﬁwt'ﬂ‘r Milt-run :r.

wmm-wm

m—w-.rv_m.wwum

‘Wmnn-VW;

March 22, 1971
my”

”up"

ml~n&lt;1uww~

..—~w«nv..p

Dr. Robert Petersen

National Institute of Rental Health
5454 Wisconsin
Chevy Chase, Maryland 20015
Dear Bob,
had the need to refer to
the
report, "marijuana and.Eealth", and on each occasion found
concise, balanced and apparently complete. You and your associates
are to be congratulated on a fine, basic document - one which deserves
a wide distribution to scientists and students.

During the past few weeks,

it

HEW

Many

I have

thanks for making the capias available to us.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

MF:kt

..

r

z

w

1:,

-.

-9 ;

-

�</text>
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                    <text>March 22, 1971
Mr. Warren K. Smoot

Assistant Attorney General
Criminal

Justice Division

Chicago,

Illinois

188

W.

Randolph

Street (Suite
60601

2200)

Dear Mr. Sweet:
NIKE

The most

definitive source of data

on marijuana

is the recent

report, "Marijuana and Health", dated January 31, 1971.

Our studies are devoted to the effects of marijuana on brain
neurOphysiology. A summary of our latest study data, and a
"position paper" are enclosed. Our contract, for studies in Greece,

is in progress but no data are available now.
If you have more specific questions we will

our assistance.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

HF

O.

kt

be glad to offer

�</text>
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                    <text>Fawn-rwu‘w—ux

4y..-.'~r;-‘n.._.

..v.-

'a: wwwv .mu-nwm I“:~'€""’T“W¢k¥u"w§=7“m;m*'w ""m-.7"1‘9W""

.

.

'

v

,

“’

M “'

March 22, 1971
Dr. C. Paul Pascurosa
3301 East Ocean View Avenue

Norfolk, Virginia

Dear Dr. Pascaroaa:
Our programs in the study of narcotic antagonists in the
treatment of Opiate dependence are expanding, and we are inviting
clinical psychiatrists to join the program. Our training division
will make arrangements for those interested in specialized aspects
of psychiatry, so that you could obtain the eXposure to clinical
problems in addiction and the psychiatric training you seek.

support our study programs. We are unaware of any
fellowships that they have considered elsewhere.
FADA may

If you are interested in a training pragram with emphasis on
addiction, or a clinical position in addiction, we would appreciate
a copy of your curriculum
A
~'-'r'

-

vitae.

copy of one of our recent

reports is enclosed.
Sincerely yours,

ammz-uvna:wnw-r-r

Max
.‘n
u
-

MF:kt

‘y-grqu-m

,_..,~

var
_

“ﬁlm”

'~

m
‘

4""

‘

'J‘Pﬂ

um:

"II-‘WI'IIWWWW'I

.wrmva

Pink, H.D.

Professor of Psychiatry

W'vmn-nv'

enc

o

�</text>
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                    <text>.ﬂ

mun-x

~va

~

'

-v','l""r"l'

W

‘

Wan‘t‘an-mrvgﬁwwrmm‘m nvA-n-rlwwmmman-.3

WNW—WW
_

-m&amp;':m‘nwl~-IV-mo?m“¢“'9‘

-----

W'.‘W&gt;'~-~

"'e-r-E-I-v1a-rusu

»r£'n'-‘Mn-.1rtr/!"~Y‘

-,"~—"#'ﬂ“r

March 22, 1971

Dr.

J.

Mandela

c/o V.A. Hoopital
University and Woodland Aves.
Philadelphia, Pennsylvania 19104

Joe,

Dear

Enclosed is a revised chapter, "The Electroencephalogram in
Clinical Psychiatry”. Your comments were cogent, and I trust I
made the changes in a useful fashion.
but

(3)

Table I has been revised.

this simplified version

It

has been published elsewhere,

can be published.

"0-.-

‘
“a.

w
&lt;
..

7-».

VMI'WFW

r,"

a'—,

"W

(11) The controversial sections on pages 9 and 10 are deleted.
There are useful for the specialist, but may have no place in a

textbook.

(14) Unfortunately, there is no good data on the
ﬁrDopa or PCPA on the EEG, and these must be obtained.

effects of

mlwmbé"

Thanks again

«r

for the excellent editing.
Sincerely yours,

WIMWVYH'mwmarAme'

Fink, M.D.
Professor of Psychiatry
Max

1n

'm'w

7m.

v

MF:kt
‘EV’IIWIYSHW‘W

.

In"

pm

w.
w"

userum

m
w

mm

«pm...

.~..,,

r
rrv

nun

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mum-I

one.

-:~-

'rv'r- -rryr..-._.

:w

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�</text>
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                    <text>awn-v

r—ﬂ'www‘vﬂw’u‘-

:- w~

up“

",—

Ww-W'...

wrww‘

mvv‘n'rnmmw-nw-WICI'rWI—v

”mv

W'v-nnnwrwrm-"j

r."

w,

mv‘w‘

March 22, 1971
Dr. Burtrum Schiclc
‘w-v

77 Barton Avenue

ﬁinneapolis, Minnesota

-'r--;w-r1~r

'-

“.mrlum‘d

-

Dear Burt,
A few months ago I completed the enclosed technical report
on the present state of the EEG program for psychopharmacology.
My

mvpvvm-

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:kt

�</text>
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                    <text>March 22, 1971

Dr. Barbara Sonowski
Hoffman ~ LaRoche

Nutley,

New

Jersey

Dear Barbara,

at

Don Shapiro and Ali Keskiner manned the CDT exhibit
Anaheim ~ Dr. Shapiro on Saturday, Sunday and Monday (March

Drs.

13-15),

and Dr. Keskiner on Tuesday (March 16). The exhibitoarea was not
open on Neonesday, although the meeting officially continued to that

day.

Both men said that the eihibit was legible and presented the
data clearly and well. The questions were largely of a superficial
quality, perhaps a reflection that the attendees were physicians of
diverse background, only a few with experience or interest in

clinical psychiatry.

Also, the exhibit

was

part of the commercial exhibit section

and may have been viewed with some caution by the
The

has a

It

visitors.

description of the exhibit

list

of about

20

physicians

was well done, and Dr. Keekiner
who asked for additional information.

Their principal suggestion has to do with the exhibit's location.
at a "dead~end", and as such, both felt the exposure was limited.

was

Their expense vouchers are enclosed, and I understand they will

be reimbursed by Hoffman LaRoche.

our
end

interesting and I believe useful for
exhibit. I will arrange “coverage" for that exhibit at the
of April.
The experience was most

APA

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

HF:kt

�</text>
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                    <text>r- vlmw~zu~.u-u. .

‘14

npv

-r

5

w~,~m'-

wyrlﬁi‘

"tum-2w

mmwnw’:

A.“ ,

March 22, 1971

Dr. H.

M.

van

Prug

Psychiatric University Clinic

Division of Biological Psychiatry
Dostersingel 59
Groningen, Rolland

Dear Dr. Van Prong:
For my presentation at the ISBP symposium on September 30,
I will present a report describing our EEG studies of heroin,
cyclazocine, naloxone and methadone; and our clinical experiences
with narcotic antagonists. A title may be:

Clinical

and

and

EEG

Studies of Opiates

narcotic Antagonists

I shall also be prepared to present our EEG and memory data
with cannabis, in discussion of the reports of others.
Although I had planned to be in Europe in Hatch, the
been postponsd.

I look forward to the meeting.
Sincerely yours,
Max

Fink, ﬂ.D.

Professor of Psychiatry

Mszt

trip has

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                    <text>Wm

'I'J-I-cm

mwr

Mhrch 22, 1971
wwrnwrmw-wvvq—wv

Dr. Barrett Scoville
Deputy Director

»~'

~'

"a,”

Division of Neuropharmacologicel

1

W

N

W

nu.

n
&lt;.

,nm

Drug Products

Office of Scientific Evaluation
Bureau of Drugs
Rockville, Maryland 20852

”VP”

Dear Dr.
nag—.7-

v'vw'"

,7

:r-

«war-rmraww—x-y-gwmwg

.-.V

:uvmmvmew"

-.—v-

-n—m

www-

Scoville:

RE:

IND

6825

Methadone is obtained from the pharmacy at Metropolitan Hospital,
York City in liquid form. The appropriate dosage is measured by
trained (R.N.) nurses and dispensed to patients diluted with grenadine
syrup. Each day's dosage is dispensed separately; patients coming to
the clinic 5x, 4x, 3x, 2x a week.

New

For £*a~acetylmethadol, we have received pure powder foam Merck,
Sharpe and Dohme Research Laboratories, West Point. Pennsylvania 19486.
This is measured cut by the licensed pharmacist at Metropolitan Hospital;
dissolved in grenadine syrup; and dispensed 3x/week. Dispeneation by the
same

trained

R.N. personnel of the methadone

unit.

Sincerely yours,

.

Fink, NJ).
Professor of Psychiatry

Max

�</text>
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                    <text>hi I»

March 24, 1971

Br. C.

J.

Mirna

University of Athens School of Medicine
Department of Biological Chemistry
Goudi, Athens, (609) , Greece
Dear Castes,

It

was good to receive your

letter

and

I immediately reviewed

the reporte in my files.
summary is enclosed. Unfortunately,
the data in, so far, insufficient for some reasons given in the
summary. Our own studies are in progress, and the preliminary
data which Br. Volavka will present in May is also incomplete.
A

You may use

this

improved within a

summary, dated as

year.

it is.

Hopefully

it will

be

to our study, I am confused. When we discussed the program
in Athens, we believed the focus to be a population evaluation
followed by a detailed examination, including laboratory tests in
a selected sub-group. A proposed outline was sent to Dr. Stefania
in early January, elicited an ambiguous reply, indicating that
changes in the law made the study impossible.
As

enclosing a capy of that proposal and timetable. I would
ask you to discuss this fully with Dr. Stefania and tell us if the
study is feasible, and whether our suggestions are useful and
practical. If not, would you propose another work-schedule, and
advise us if the legal problems can be solved?
I

am

Good

luck

on your volume.

Sincerely yours,
Max

Fink,

M.D.

Executive Director

HF:kt
enc.

cc: Dr. Stefania

"1"10‘

,r ...,,.

�</text>
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                    <text>March 24, 1971

Stefania
Eginition University Hospital

Dr.

D.

Vassilissis Sophias
Athens, Greece

74

Dear Costas,

Enclosed are capiea of a

letter to

Dr. Miran sent today.

I ask you discuss our original suggestions of January 4
and advise us as to its feasibility, your criticisms and
him
with
any alternate suggestions.
May

My

best wishes .
Sincerely yours,
Fink, M.D.
Executive Director
Max

MP

:kt

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                    <text>mw-amvxs-g...r—. .

March 25, 1971
Dr. Ali Keskiner

Institute of Psychiatry

Missouri

5400 Arsenal

Street

St. Louis, Missouri 63139

Dear

Ali,

Apparently, the trip to California was successful. I have
requested the reimbursement of your expenses and you should receive
these within the next few weeks.
we

For those physicians who have requested additional information,
had planned to send them copies of the two CDT reports:
Holden, J. M.C., Itil, T. M., Keskiner, A. and
Fink, M. Thioridazine and chlordiszepoxide, alone
and combined,

schizophrenia.

Itil,

in the treatment of chronic
Comp. Psychiat., 2; 633-643,

T., Holden, J.

M.

C., Fink,

M.

ﬂhapiro,

1968.
D. M.

and Keskiner, A. Treatment of chronic psychotic
patients with combined medications. Proceedings of
the Vth International Congress of the C.I.N.P.,
Washington, March 1966.

reprints here, since the bulk was kept by
it be possible to send a copy of each reprint
to each of the physicians who signed for them? (Also, would you

We do not have the
Mike and Turan. Would

please send

me

a few copies of each

article?)

Before Turan left, he indicated that he might be back in time
for the APA and, if so, he would participate in the exhibit. I
would like to call you a week or so before the meetings and perhaps
you and I, with or without Tursn, can arrange to cover the APA exhibit.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF:kt

i

\

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