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                    <text>November

’Iw‘vlﬂ‘vr

Mm’

~

8, l97l

Dr. Walfer Essman
York

New

'smmr

ley

Dear Wall,
Many Thanks for your flne confrlbuflon lo The ECT
Issue of Seminars In Psychlafry. The reporfs are all In the hands of
the pibllsher, and you should recelve galleys In 6 weeks. The Issue
Is due In February.

call
+0

Your
me.

fhe Journal.

should recilve, as a

You

And,

and cooperaflon.

My

ldenflflcaflon Is Ilsfed,

please accepf

my

and If Incorrecf, please

glff of

+he

publisher,

3

subscrlpflon

fhanks for your fine confrlbullon

besl regards. (Please call

me

when you

refurn).

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry

�</text>
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                    <text>November 8, l97l

Dr.

Ferris Plffs

Sf. Louis, Mlssourl
Dear Pefe,

varlous arflcles for The ECT Issues of Semlnars
of fhe publlshers. The Index and
Psychlafry are
Idenflflcaflon nofes for The aufhors are enclosed, and If fhere Is
an error, please lef me know.
The

In

The galley proofs should
In February.

fhe Issue Is due

arrlve wlfhln

6

The publlsher ls grateful, and will send
fhe journal.
fo
subscrlpflon
And,

—-

..

.quv—m»

In fhe hands

I

flnally,

hope fhe Issue Is wedl

be.

Many

fhanks.

I

weeks, and
you a

van? #0 fhank you for the fine arflcle.
know fhaf your reporf wIII

recelved, for

I

“awn-”am.

-v—v

Slncerely yours,

mm...

..
v
w-

n“

-.—.-

WW

~qu

vw-r

wwu—w—WWF—I'MEWFW

Max

Flnk,

M.D.

Professor of Psychlafry

�</text>
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                    <text>November

8, I97!

Dr. Wiiiiam Kariiner
i749 Grand Concourse
Bronx, New York i0453
Dear

Bill,

enclosing a draf? of the Q &amp; A secfion of The
forfhcoming speciai issue on ECT of Seminars in Peychiatry which is
due To appear in February. We have digesied fhe various answers, and
are presenfing ihis 'digesf', wifh some ediforiaiizing. Any
suggesfions wiii be appreciafed.
i

am

van? *0 fake This opportunify to +hank you, no?
only for This confribufion, bu? The unsfin+ing supper? you gave our
sfudies a? Gracie Square.
i

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>November

8, i97i

Dr. David impasfafo
46

New

Fiffthvenua
York iOOIi

Dear David,
i am
enclosing a draff of +he Q &amp; A sacfion of 1he
forihcoming Special issue on ECT of Shminara in Payahiatry, which is due
i0 appear in February. We have summarized the various answers and are
presanfing this digesf with some odiforiaiizing. Any suggesiions will

be appreciafad.

opinions.

Many

My

Thanks for your promo? cooperation and

franl

has? regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiafry

�</text>
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                    <text>"WWW!“

~— -—.

m. wr‘m.‘ :mvﬂmwv—w-w ,»m~—wr—mwm.—~—va~———m-~~—
~—

-‘4-

November

8, l97l

Dr. Lothar Kaiinowsky

ll5 East

New

82

Street

York City

Dear Lothar,
i am
enclosing a draft of the Q &amp; A contribution to
the Special issue of seminars in Pbychiatry. Following your suggestion,
the contributions are summarized, and i am enclosing a copy for your
information. Any suggestions for changes will be appreciated.

that

it

issue will appear in February, and i am hopeful
will complement your text, which is the standard.
The
My

thanks for your cooperation.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

———_ -«

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103558">
                    <text>o-unr

WWrr-—w-—..._r,ww

~w-—mmm..wm, “WW
.

.

w

.

m.

.»-...r.

m.._..__...‘.

._

.s.7

..._,......;......___.7. “V.

.

.

.__... H.._~,~.w. ..

w,

..

.

.

a

November 8, l97l

Dear Turan,
IT was a pleasure To have you visiT.
ACNP
The
enjoyed
meeTlng, and voTed our friends in.

I

hope you

am enclosing a xerox of The page proofs of The
fenfluramine arTicle. have found 2 errors (noTed). if you find
any oThers, elTher wriTe me of To Springer Verlag, Heidelberg,
i

l

Germany.

Mr. Pavel has checked The cosT of The parTs for The
in
small
boxes-quanTiTies, $34. Should you wish him To build
These, he can do so. I would suggesT $75 each, paid To him.

How

many ?

Andy Don

clinical populaTion,

arrived This afTernoon, and

had

i

a good

could underTake some of The sTudies we discussed.
i will
Try To esTablish him aT The VA, and should he succeed, we
could do parallel sTudles, should The markeT call for such work.
i

Send us your Tapes-- as l suggesfed, iT would be
To
have a l0 minuTe run of an oscillatory signal
helpful
so ThaT we could check The sysTem before you record a loT of daTa.

mosT

My

besT To Ellen and The

children.
As

ever,

.w

�</text>
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                <text>Correspondence to: Itil, Turan M.</text>
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              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
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              <elementText elementTextId="50818">
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          </element>
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            </elementTextContainer>
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            <elementTextContainer>
              <elementText elementTextId="50821">
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              </elementText>
            </elementTextContainer>
          </element>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="50822">
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          </element>
          <element elementId="48">
            <name>Source</name>
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              <elementText elementTextId="50823">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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          </element>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="85845">
                <text>application/pdf</text>
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            </elementTextContainer>
          </element>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="92406">
                <text/>
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          </element>
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              <elementText elementTextId="98967">
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                <elementTextContainer>
                  <elementText elementTextId="103557">
                    <text>November 8, 1971

Miss Frances Morrall

Chronic Disease Management
801 Second Avenue

New

York,

New

York 10017

Dear Miss Morrall:
and I

letter

of July 9 was misplaced in my
regret not having answered it when received.
Your

files,

I am taking the occasion to enclose the report you
requested, and some background information, should you still
wish to use them.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:ig
Enc.

�</text>
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            <element elementId="50">
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                    <text>Il

“mm_ﬂ_‘

WWW—w...

~W

November 9, l9?!

.w—u—v—"n—

v-W.w—w

Drs. Joyce &amp; Ivar Small
lndlana Unlverslly School of Medlclne
lndlanapolls, lndlana

v

VWW

«W

-—

—-

Dear Joyce and

lver,

varlous reporfs for +he ECT volume ln Seminars
In Psychiatry are now a+ fhe publlsher, and fhey have a planned Issue
am encloslng the llsf of authors, and
dale of February, l97l.
ldenflflcaflon/addresses. lf correcf, please do nolhlng. If lncorrecf,
please wrlfe me.
The

I

fhe Seminars.

You

should recelve The galleys within

6

You

wlll also recelve

subscrlpllon To

a complemanfary

weeks.

fhanks for your flne confrlbuflon. l fhlnk the
Issue wlll be a useful one, and your report ls most valuable.
My personal thanks for The fine cooperaflon.
Many

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychlafry

�</text>
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                    <text>“w,

«arm—MW‘u—wvsv-

—~

nu.-..,..r..t.g—v—

.r

.

wv—.-— p

7”...— iv...- mw—wn-wvn—wmww—uu—w—u—u ~.w—.—...v~.,.»..._..m~~_-—nv—w

w.

—

fr...»

'I‘-«_-'- .

—-

&gt;~\W;L'ﬂn.m—«v-.. w... 3,...

n

v

,

. -~-

November 16, 1971

Dr. Robert C. Petersen

Center for Studies of Narcotic

&amp;

Drug Abuse

National Institute of Mental Health
5600 Fishers Lane
Rockville, ﬁaryland 20852
Dear Bob:

In response to your request, we are pleased to send this report and appendices, using as notations the numeric references of your

letter,

10/26/71.

With regard to the

last question,

we

have had unusual, and

to us, unnecessary delays in obtaining marijuana and THC. Our requests
require 3~4 months of processing, and in the 21 day study, the Committee's suggestions (interdictions?) as reported by Dr. oroude, were
not based on experience satisfactory to us. The delays resulted in a
loss of half our sample, who were available for study during the summer
only. Since research effort, if truly innovative, will be novel to the
Committee, it may not be possible to satisfy their anxieties, leading
to covert behavior on the part of investigators. Perhaps, investigators
who have passed the hurdles of institutional peer review, NIMH peer review, and

clinical

and research experience, warrant the same deference

to their judgment in regard to studies of cannabis is is accorded their
studies of other substances in the service of man. The present Commit—
tee or its spokesman seen to assume prerogatives not ordinarily accorded

advisory colnittaas. It would be a welcome breathe of moderation and
restraint for the Committee and 31MB authorities to exercise less demanding control over the minute details of experiments and experimenters
with regard to a drug as extensively studied as cannabis.
make

Should any additional data be required,

than available.

we

will

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

HF:ig
Enc.

he

slid to

~.

�</text>
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                    <text>Novsubsr 16. 1971

Barrett Scovills,
Deputy Director

M.D.

Department of Health, Education
&amp; Welfare
Food 5 Drug Administration
Rockville, Maryland 20852

Dear Dr. Sioville:

studios under

Vs
IND

progress report.

hsvs conplsted the snclossd summary of
4724, and are submitting this cepy so our

Sine-rely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mrzig

�</text>
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                    <text>November 16, 1971

Dr. William Bunney
Acting Director, Center for Studies of

Narcotic and Drug Abuse
Rockville, Maryland
Dear Dr. Bunney,

Thank you for the invitation to attend the meeting of
Advisory Committee on Friday, November 19 in Bethesda. I
look forward to attending, and will arrive that morning by 9:30 a.m.

the

Ad Hoc

The arrangements

and

for reimbursement are satisfactory.

I will bring some notes as suggested in your letter,
will plan to present a short overview of our studies in opiate

antagonieta and cannabis.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>November 16, 1971

Dr. Allen Berger

Pfizer Pharmaceuticals

Groton, Connecticut 06340

Dear Allen:

Enclosed are two copies of the behavorial data summary
of the comparison of doxepin hydrochloride (25 and 10 mg) and
doxepin pemoata (10 mg) in male volunteers. The behevoriel

data parallel: the EEG data quite well. It is this date that
clarified for us, the differences in behavorial data obtained
on a moment-to—moment basis compared to summary data at the
end of an experiment.
An

quested

My

extra

it.

capy

is enclosed for Dr. Beckett, as she re»

best regards.
Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Hex
Wu".

MF:ig

Inc.

�</text>
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                    <text>.7...__

cavvr ,

.

w“..-r_._._._-

”us—1..

wwwww—v... Mr 3..“

-m ”aura-w.

.

.

.mwr-twwwm~mw .m.

my”,

W-..i....r.

Hovssbsr 18, 1971
Robert Rees. H.D.

Special Action Office For Drug
Abuse Prevention

White House

Hashington, D.C. 20506
Dear Bob:

Since the September meeting of SAODAP, we have reviewed our
programs in New York and Al Freedman and I are writing to acquaint you
with our immediate projects.

sured

We

plan to expand our studies of nsloxone.

We

have been

as—

by Ralph Jacobson that naloxone pamoate will be available for
by the end of the year. We have filed the necessary
clinical
forms for an IND, and will give this study our highest priority. We

trial

are also continuing our studies of high dose oral naloxone, and are t
testing dosages from 1.0 to 1.8 grams. This study will parallel the
psmoste. In both studies, we will assess the duration of antagonisiu
with heroin challenges and clinical acceptability.
Our interest in M—SOSO and BC 2605 has led us to file and
N.I.H.H. application for support of the antagonist studies. The applicstion requests funds for the necessary animal trials to obtain an
1RD for M-SOSO, and should we obtain this IND, we will
assess the du~
rstion of sntsgonisu sad sccsptsbility as an antagonist in our clinical
population. We have not made s psotocol for BC—2605 since our facilities
sre cousitted to thsss prior studies. To expand our facilities, how—
ever, so srs sstshlishing s clinicsl research unit at the Montroso V.A.
One of my students. Alexsnder Don, hss sgrssd to set up the unit and
hss joinsd thst staff this week.

�Robert Rees, M.D.

recently completed our comparison of l-slpha-acetylsethedol
that report was sent to your office. We
believe that this compound can be used more widely and further testing
should be done. We have urged Dr. Richard Brotnen of our College to
undertake a large scale clinical study, using the College methadone de~
toxificetion program as a base, and he is preparing the necessary doc—
unentation for city authorities.
We

and methadone, and a copy of

Bristol has requested that we assess the safety of naloxone:
in a ratio of 1:10, and one member of our staff. Dr. Richard
Resnick, has written a protocol for this study.

methadone
0

..'ervr-~

-:':'

'Ir'

Wutv'r‘n

wo‘rw.

November 18, 1971

chiatay;

Our latest cyclsxbcine report is in press in Comprehensive Rayand the report of our methadone—cyclesocine transfer study is

being revised following

editorial criticism.

Our trails with silsstic/naloxone are not funded beyond the
end of the month. The data are interesting, suggesting that
is fea-

it

sible to delay the release of naloxone, but are not sufficiently conclusive to warrant our enthusiasm.

heroin,

Under another program, we are continuing our EEG studies of
with one aim the development of an objective index of narcotic

antagonism. We are also studying the neurohumorel consequences of opiate
use; and our cannabis program is most active. But these issues are of
less immediate public concern.
Should your office obtain funding, two of these projects wer-

Iant your attention: animal toxicology of

M-SOSO

sufficient for

an IRD,

as described in our N.I.M.H. protocol; and a large scale comparison of
nethedol and methadone. While we have not prepared a protocol and bud~
get, this can be done.

wish to implement the recommendation that addiand pro-clinical testing of analgesics and
antagonists be establishdd, we have reviewed the facilities and personnel
available in New York, and believe that a viable program could be es—
Should

SADDAP

tional centers for clinical
tablished, capitalizing

facilities.

on

the affiliated college, city,

state,

and V.A.

Finally. there is one delicate matter that should be brought
to your attention. In discussions with Ralph Jacobson, he has repeat—
edly alluded to the support from your office for the naloxone studies
in this institution. We did discuss funding from Endo with his, in part,
for the special tests and reports that they usually require at the end of
each study. Also, in our discussions with Dr. Irwin Pechter of Bristol
Laboratories, we have indicated that support of our study programs is
essential to their vitality, and that transfer of this support to governmental agencies are not particularly useful. (You may recall that Ster-

�November 18, 1971

Robert Recs, M.D.

ling~w1nthrop provided us with funds for our cyclczocinc studios ~fundo that wcro used for oquipncnt. travel, and consulting not ordin—
arily available in governmental contracts). I would hope that the parof ncrcotic
allel, direct Iupport by Endo and Bristol, of then: studios
antagonists, will not be projudiccd by implied proniocs from SAODAP.

‘-

'H'srxw-"mro'ivv-uuv

v

We trust those
succcooful launching of

comments
SAODAP

are uscful, and look forward to tho
in tho near future.

programs

Sincerely yours,
Mu Fink,

,

at,

WIN“

V‘Rﬂ‘

"'

'-r"smm-

HOD.

Professor of Psychiatry

42v"

HF:ig

�</text>
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                    <text>'vmm'

Novenber 18, 1971

Dr.

Fritz Frcyhcn

St. Vincent's Hospital
153 West 11th

New

York.

Dear

New

Strﬂet

York 10011

Fritz;

Encloeed is a revised draft of our report ”Clinical
Experiences With Multiple Electroconvulsive Treatments".
We have reduced the
tett as suggested.
Again, our thanks for your consideration.

Sincerely yours,
Max

Fink,

24.1).

Professor of Psychiatry

MF:1g

Enc.

�</text>
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                    <text>November 19, 1971

Dr. R. Mechoulam
School of Pharmacy
Hebrew

Israel

University of Jerusalem

Dear Dr. Hechoulamm

I

am

pleased to enclose an import permit (#3273) for
air freight, and the permit should

1476. This may be shipped by
accompany the shipment.
EA

I have also received your letter regarding the antagonist.
I can and will send some naloxone, but would like to discuss your
letter with Professor Freedman first, as he may have some suggestions
as to the eventual testing of the antagonist.
you

I trust the lectures in Stockholm were interesting. I thank
copy of the program.

for a

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Novemher 19, 1971

Craig Burrell, M.D.

Sandor Pharmaceuticals

Hanover,

New

Jersey

Dear Craig,
Some

time ago you requested some information regarding our

regret that the letter
is enclosed. and should
allow
fate to this
same
the
wish
will
I
not
additional
data,
you
request.
studies of thioridazine

wee misplaced

until this

and thiothixane, and I
week. The information

I trust the information

may

be of

interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Howunbor 22, 1971

Dr. Donald

J. Jcnder

Department of Pharmacology
UCLA School of ﬁcdiciue
Los Angeles, California 90024
Dear Dr. Jender:

l was pleased to hour of your work and the techniques for
measuring low levels of acetylcholine, at the ﬁIHH meeting Friday.
Some years ago. in studying the electroshbck
process, the specificity
of anticnolinorgic drugs in reversing the ECT effect led me to poatulcte an elevation of acetylcholine as important to this effect. We
attempted some measures of CSF acetylcnoline, but our results were
unreliable. Recently, I approached the problem again, and sent some
fluids to Walter Essmau at Queen's College, ﬁew York, but he was cola
to measure other constituents, not acctylcholine.
Are the techniques yen describe ouitablc for CSF? is there
a way of stabilizing CSF~acetylcnolinc so that samples could be shipped?
Would your laboratory be interested in some samples of CSF in monkey.
and man, before and following ocizurca, to test the hypothesia
ccetylcholinc eiotation occurs and persists post~ECT7

any

I an enclosing a copy of my 1966 rcport,
relevant citations from your lnborctory.

and onould appreciate

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

ﬂF:ig
Inc.

that

�</text>
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                    <text>Novcmbcr 22, 1971

ﬁarold Mciselas, H.D.
Commissionor

Narcotic Addition Control Commission
1855 Broadway
York, ﬂew York 10323

New

Dear narold:

I

have road the

list

of Suggested examinations for methadone
was suggested for research
or as the basis for a more complete examination of methadone treatcd
patients. As a caries of research issues, the suggastions are vague
and seem to reflect a general clinical neurologists' approach to a
problem, without appreciation of tho complexity of the interaction of
opiate dependence, its complications, and methadone.

effects. It is not clear whether this list

(1)

Clinical exam: routine medical, and usually unchanged
by methadone. The "mental status”, of course, can be

very detailed and

euphorigunic,

(2)

(3)

(4)

is the basic for exhaustive studies of

memory,

perceptual, 355, effects of methadone.

ouch a routine EEG is of very limited value. In the
studies that have dissected the EEG effects of methadone,
quantitative measurlncnts were necessary. These did not
show significant regional differences and from our past cx~
variance, such differences are rare with drugs.
EEG:

few

Ancillary

interesting theoretic speculation, with
Despite many studies of drugs, the
changes only ct very high dosages, and tho-o
hcvc usually been non-contributing to our understanding.
EEG:

little foundation.
AER shows

20M: interesting, but probably of little relevance to
nothadonc‘s mode of action. Again, only changes at very
high doccc of drugs or with those which specifically affect

labyrinth: or vcstibulor nuclei (0.3., barbiturates,

esthctica).

an~

�</text>
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                    <text>E

Novamber 22, 1971

Dr.

J. 0.

Cole

Boston State Hospital
Boston, Massachusetts 02124
Dear Jon:
Should you wish to exoand yoor program to include EEG measures.
are pleased to couparato and analyze the tapes using our IBH 1800
systam. Our present recorder is a Hewlett Packard 3960 A (1 7/8, 3 31‘,
7 1/2 IPS, 6 track, 1/4 inch, PM) and your lab should have a compatible
recording system.

we

In addition, it is useful to have a sine wave oscillator
(similar to ﬁ.P. 2020c) and an oscilloscope monitor. We ”charga” users
according to the hours of computer time for EEG analysis and for such
statistical analyses as are required. For the usual studies you might
complete in a year, $4,000 should be very adequate.

Finally, should you need a new EEG, we have found the Grass
polygraph with 7P511 amplifiers stable and most satisfactory. For a
4-channel portable the coat is about $4,000; and an 8-chanaol about
$8,000.
We

would

to pleased to cooperate with your laboratory.
Sincerely yours,
Fink, M.D.
Protozoa: of Psychiatry

Max

MF:13

�</text>
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                    <text>\J

I"

ﬂovembcr 22, 1971

Harold Moisolao, 8.0.
Commissioner

Narcotic Addition Control Commission

1855 Broadway
New York, New York 10023
Dear Harold:

I have read the

list

of suggested examinations for methadone
was suggested for research
or as the basis for a more complete examination of methadone treated
patients. As a series of research issues, the suggestions are vague
and seem to reflect a general clinical neurologists' approach to a
problem, without appreciation of the complexity of tne interaction of
opiate dependence, its complications, and methadone.

effects. It is not clear whether this list

(1)

Clinical

exam:

by methadone.

routine medical,

Tue "mental

very detailed and

euphorigenic,

and usually unchanged
status”, of course, can be

is the basis for exhaustive studies of

memory,

perceptual.

Egg,

effects of methadone.

(2)

such a routine EEG is of very limited value. In the
studies that have dissected the EEG effects of methadone,
quantitative measurement: were necessary. These did not
show significant refusal differences and from our past exporionceg such differences are rare witn drugs.

(3)

Ancillary EEG: interesting theoretic speculation, with
little foundation. Despite many studies of drugs, the
AER shows changes only at vary high dosages, and these
have usually been non~contributing to our understanding.

(4)

EEG:

few

Bode:

interlacing, but probably of little relevance to

nothcdone's

mode of action. Again, only chnngcs at very
high doses of drugs or with that: which opecificolly affect

labyrinth: or vestibular nuclll (2.3.. barbiturates,
actuation).

an—

�Harold Mbisolnn, M.D.

Novonhot 22, 1971

similar to 3, 4.

(5)

Blood flow:

(6)

significant test, which is under study in many
laboratottes. Thar: at: at least 3 important issuau:
Rt undo: oinulntod conditions (9.3., drowsy); simple
R.T. and complex R.T. Also, intranodnlity and internodslity issuas are critical. If done preperly, such a
program could be of interest (oopecially simulated R.T.).

(7)

Conduction volocity: as prepared, a test of limited
value. This in a highly complex procedure that may (like
R.T.) warrant intensive study by exports, using sophis~

Rt:

A

ticated methods.

For each item, 1~7, there is
methadone treated aubject.

in each
I

ﬂy

trust those

comments

little

merit as a ”routine" test

are responsive.

If not, please call.

best.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry
MF:ig

�</text>
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                    <text>._.W_,..r... _. .1wh...

.

.

'vayvi- ..

.1.

v...—w...,._...y-v——

-

Hovaaber 23, 1971

Dr. R. Mechoulam

Laboratory of Hatural Producta
of Pharmacy
The ﬁchrew University of Jerusalem
Faculty of Medicine
Jerua elem , la rael
The School

Bear br. Mechoulam:

Separately I have sent you the import permit of

EA

1476.

There is much interest in the antagonists, and particularly in
a long acting formulation in this country. I have attended two meetings
focused on this problem during the past month. The immediate focus of
interest is in naloxona pamoate, which in animal trials releases naloxona
for 10—14 days. we will begin an assay of this material in January.
At present, the two best antagonists are naloxone and l—cyclarocinc,.
Naloxone is enclosed. For l-cyclaaocinc, samples would have to be ob—
tained from Dr. Sidney Archer, winthrop Laboratories. It is also probable
that ﬁ~5050 of Beckett &amp; Coleman may to useful, but neither lccylaaocina
or M—SOSO have racoivad touting in man. Therefore, for the present, nal~
ozone in the drug of choice. Should you believe the chemistry of cycleaocino would be a better choice, I would suggest you write Dr. Archer
for a sample of l-cyclazocino to test.

The testing is a problem. I recall that the Israeli pharmacologiata were able to assay the duration of action in animal subjects, uaing
morphine challenges. Ia that correct? Our facilities permit us to aaaay
the duration of antagonism in nan, using heroin challenges. Ha have not
been able to undertake toxicology studies in our laboratories, and have
been trying to obtain the funda to study M~5050 under a contract. Thio
it under review. Should you uaka some aanplaa available that you believe
has a long release rate, we will try to assess the animal duration (rclcaae) and if intaraating, arrange for the other trials.

�w
rrv ‘mII—u -m,.—,_..vwn—.J,u‘“

.“pwwﬁﬂ.”

.wu.n...,wm,wwwrvywvwﬁw,

November 23, 1971

Dr. R. Mechoulam

chare grateful for

E

'

be remembered to you.

your

interest,

and Dr. Freedman asks to

Sinceraly yours,
..W-wvv'ﬂ

Max

Fink ,

14.1).

Professor of Psychiatry

:ig
lie.

biF
mw—mmrmw

,w—rmm.

v
”.2.”

�</text>
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                    <text>Hounnbcr 23, 1971

Mr. Karat Bosteman

Deputy Director
Division of Narcotic Addiction
&amp;

Drug Abuse

ﬁlﬂh

5600 Fishers Lane
Rockville, Maryland 20852

Dear Karst:
have been invited to participate in the Fourth
National Conference on ﬁethadone Treatment in San Francisco
in January. Dr. Ivan Bennett has asked that we present our
experiences with the antagonists and 1~alpha methadol. I
am writing to ask support for one investigator to attend
We

this meeting.

The

is

principal support for research for opiate

from the stata of ﬂow York. Last week the
commission cancollcd tho oxpcnditure of all travel funds,
making attendance at this stating unfaasible for us.

dependence

IIIth of

Ho

would

b: gratoful for financial support for

IV

staff to attend this routing.

Hy

beat with...
Sinccroly yours,
22:: Pink,

5.».

Professor of Psychiatry
83:13

8

�</text>
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                    <text>November 23, 1971

Lothsr B. Kalinowsky, ﬁ.D.
115 East 82nd Street
York, ﬂew York 10028

New

Dear bother:
Your comments about the

Q

s

A

were most cogent.

We very much
regret 'mieleading' you. In our first discussion, I had hoped to be able to quote the answers from each re~
spondent without any summary. out so many responses were of the ’yee'
and 'uo' variety, which seemed unreadable unless we provided text and
substance. This, Dick and I did. Perhaps, it is unfortunate that we
tended to quote the more complete responses, even when we disagreed
with them. Your comments led us to edit the answers, and I am enclosing
a revised text.

Should this text meet with your approval, we can make these
corrections in the gslleys. Should this correction not meet with your
approval, perhaps you would make other corrections, and we could edit
the galleys.

If there is another

course that

will serve your interests

and those of our readers, we should be pleased to hear from you. I
expect to use you in Mexico City, where we may be able to have an op-

portunity to resolve this question at leisure.

Again, we are grateful for your candor and c00perstion.

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

Hfzig
Enc.

�</text>
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                    <text>Novoaber 23, 1971

Honorable Mr. John Tunney
U.S. Senate

washington, D.C. 20510
Dear Mr. Tunney:
2809

In response to your suggestion, I have read the text of Sonata

- a bill to establish six regional centers of excellence in drug

abuse research and education.

The intent is admirable and the mission necessary. But the
has two major flaws it defines the centers on a regional basis;
and in the text, allows tne assignment to possibly be made by the White

bill

—

House.

Selection of centers on a regional basis will inhibit the de—
velopment of centers in proximity to each other; and encourage some to
develop where no experience exists. If one center is encouraged in the
far West, should it be in Los Angelou, Palo Alto, or Portland ~ three
active research centers? In New York, should it be at the ﬂew York ﬂedical Collage, Downstatc ﬂedical Center, Albert Einstein Medical Center
or SUNY at Stony arook — each center now having active programs and fine
leadcra?
The proaant Senate 3111, 82097, provides for a transfer of authority tron NINE to the White House. This transfer, for research and
education, is fraught with the hazard that the White House will enclurnge
political appointees without adequate regard for scientific experience.
It will be a handipap to the present research efforts in drug abuse, al-

coholian, and psychopharnacology to have the authority for research transferred to tho limited team aasemblod there now. The good intentions of

$2809

will be subject to political considerations, independent of excel-

lence of centcra, and will not achieva the resulta wiahcd for
ity in in the White Houac.

if

euthote

�Honorable Hr. John Tunnoy

November 23. 1971

it

not true that tho mechanisms for the results anticipated
exist in the program grants and the career awards of
the National Institute of Mental Roalth? Perhaps the aaciact way to
achieve the mission is to allocate additional, earmarked funds for drug
abuse research and training (an: on a regional basis). Indeed, the lim—
itations in tho present prograanatic aupport in the shortage of funds,
not the shortage of applicant: or ideas.
Is

by 32809 already

Should you wish to discuss these
I can be reached at 212~369-7900.

comments

in public or in caucra,

Sincerely yours,
ﬂax Fink, H.D.

Professor of Psychiatry

MF:ig

cc; Senator d. Hughes, Iowa
Senator J. Javits, New York

�</text>
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                    <text>November 23, 1971

David

40

New

J. Impastato,

Fifth

York,

Avenue
New

M.D.

York 10011

Dear David:
Your comments on the Q
A section for the forthcoming
issue of Seminars in Psychiatry were most helpful. We have re—
vised the sections most relevant to the suggestions, and I am
pleased to enclose a revised copy for your files.
&amp;

candor.

Again,

we

want to thank you

for your cooperation

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Ming
Enc.

and

�</text>
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                    <text>1..W— Mm:—

mm.

,....,,,_..—w_v—————

November 25, 1971

Representative Paul Rogers

u.s.

House of Representatives
Washington, D.C.
Dear Mr. Rogers,

It

was kind of you to spend so much time

to discuss the pending drug abuse

legislation.

last Friday

return to New York, I discussed the suggestions for
increased participation by scientists for the hearings next week with
On my

Drs. Alfred Freedman (New York ledical College), Jonathan 0? Cole
(Boston University), and Daniel X. Freedman (Chicago 0.), and each
indicated that participation in the hearings would be beneficial.
Should

it

Should

this

be useful, I will be available on Thurdday,
Besenber or Friday, December 3. I plan to return from meetings
in Mexico City Wednesday afternoon, and could change my itinerary to
arrive in Washington Wednesday evening.
2

be

useful, please call

(212 369 7900 x245,246) and my secretary will
telex the Camino Real Hotel in Mexico City.

my

office in

New

get the message to

York
me. Or,

Dre. Alfred Freedman, Jonathan 0. Cole and Daniel Freedman
AP: 212 369 7900 x222; JOC:
can also appear and can be reached at
617 436 6000; and DXP: Department of Psychiatry, U. Chicago.
—

legislation
the nation.

Again,

my

thanks for the opportunity to discuss the pending

which seems so important to the drug abuse control

efforts of

Sincerely yours,
Max

FInk, M.D.

Professor of Fsychiatry

�</text>
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                    <text>November 25, 1971

Dear Dr.

Aylett,

Yesterday afternoon, the mail delivery brought your letter,
dated October 7, 1971, indicating that you would be in New York
this
week, and would like to visit. I very much regret that the letter
had not arrived earlier, for I would surely have written and made the
arrangements you requested.
For your information, the letter was postmarked Oct 8
from S.E.5; the postage was 9 pence; marked airmail-— but
must have
been sent by surface mail.

it

Should your office receive this in time to send you a
note,
would be pleased to have you call on December 10, for I will
be
in my laboratory, and would be pleased to have you visit:
call~ 212 369 8488; or at night— 516 466 5444.

we

Regretfully,
sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>September 7, l97l

Dr. G.F. Blane
G.F. BLANE, RECKITT
Pull, England

&amp; COLMAN

Dear Gerry:

Enclosed is a U.S. import permit #3252 for the
1

tnﬂlsfer of

official

of Etorphine. I would appreciate your
sending copies of the available reports on the human use of
Etorphine, and as much of Etorphine as you can make available.
,

I have

gm.

Just returned

from Europe and will be

the

attending
meetings in Washington on narcotic antagonists on September 9.
Many thanks for your cooperation.
Sincerely yours,
Max

MF/rs

Fink,

M.D.

�</text>
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                    <text>September 9, 1971

It

To Whom

May

Concern:
RE:

Maureen Garcia

Mrs. Maureen Garcia has been working for me as an EEG
Technician since October 19. 1970. She received her training

at

New

York

University.

is a dedicated worker with a serious interest in providing
artifact free records. She is fuiiy trained, and I believe, can
make significant contributions to the A.S.E.T.
She

Sincereiy yours,
Max

MF/rs

Fink,

M.D.

�</text>
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                    <text>September 9, 1971

Mr. Leon

Brill, Director

Dear Mr.

Brill:

Bureau of Program Planning
N.Y. Narcotic Control Commission
1855 Broadway
New York, New York
10023

writing in regard to your request for permission to reprint
our article "Narcotics Antagonists: Another Approach to Addiction Therapy".
This article has appeared in a principal Journal and has been reprinted
I am

publications already. It would serve little purpose and would
reflect on our integrity to have it reprinted again.
in

two

I

regret that

I cannot

grant permission to reprint this material.
Sincerely yours,
Max

MF/rs

Fink,

M.D.

�</text>
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                    <text>September 9. 1971
Dr. Louis A. Gottscha1k
Professor and Chief

Department of Psychiatry

5 Human

University of Ca1ifornia, Irvine
Ca1ifornia Co11ege of Medicine

Behavior

S. Manchester Avenue
Orange, Ca1ifornia 92668
101

Dear Lou:

writing in support of the app1ication of Dr. JohnhimKramer
for promotion. I am de1ighted to do so. for I have known
since 1930 and have fo11owed his career with interest.
I am

received part of his training at Hi11side Hospita1 with me,
exhibited exce11ence as a researcher. which 1ed me to recommend
him for a research career. He e1ected to try his hand in private
practice and, as you know, returned to an academic career about
six years ago.
Since then, he has contributed to our understanding of
opiate and amphetamine psychosis. In his presentations I to
have
scientific societies. he is carefu1 and conservative.
for
me
a
in
him
formu1ating
program
asked
to assist
recentiy
been
have
in
and
regard
this
contributions
his
heroin de1ivery
dependence
in
nationa1
His
prominence
opiate
most bsefu1.
research has 1ed to his c1ose association with the specia1 office
of the President, devoted to drug abuse contro1.
Because of his research interests, his keen awareness of
po1itica1 issues. and his contributions to the prob1ems of
He

drug dependence, I

am

p1eased to recommend him for promotion.
Sincere1y yours,

Max

MH/rs

Fink,

M.D.

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                    <text>m -.-. .. -&lt;u~

.31...- m' ATV-nﬂplw—H

September 10, 1971

Director
BNDD

Department of Justice
Washington, D.C. 20537
Dear

Sir,

I have filed for and hold BNDD registrations #
for the investigation of opiates
and cannabis derivatives. In requesting supplies of cannabis
from the National Institute of Health, Dr. Monique Broude
requested that I submit, in addition to the proper protocols,
completed order forms, 9 222C.

AF

1732103 and PF 002455

I am writing to request a supply of these forms,
properly imprinted, for the continued use of these study

programs.

Thank you

for your cooperation.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Septemebre 10, 1971

Dear Andy,

I spent 6-days in Europe,
exhausted, returned to find your
some maneuvers

for you.

two

in Washington, and

letters,

First, as to your questions.

and to the Department of Psychiatry,

somewhat

and immediately

tried

Your appointment to the V.A.

should,like all appointments at

the medical school, be independent of me or any other person—all appointments are for an indefinite term, and while tenure
is granted only after five years service, there are no discharges
of staff members except with an extensive warning.
to the visa, I called Washington and after

As

many

calls,

reached the best office. I indicated that your appointment to the
VA was in the national interest since you are coming to develop
a drug addiction treatment program focussed on the returning

Viet—Nam

file

a

veteran. Under these conditions,

special

will allow

"Temporary 'H"

petition"-~

it is

and

if

possible to
approved,

it

you to come to the states, and wait here for the
permanent number to be assigned. At that time, you will have
to visit the immigration offices (possibly in Washington) for
certain formalities. With this information, I am prepared to
file this petition on your behalf, and will do so as soon as it

is received.

The State Board problem is more thorny. Dr. Volavka has
struggled with the Board, and I would defer your questions to
him. As he is in Athens for a.few weeks, I will hold up this
inquiry until he returns, and ask hint to answer you.

I do not know about bathelo quarters at either location,
but will defer this inquiry also until some data is established
and then can ask

specifically.

In Washington this week, the principal question was the
ways to expedite the development of a narcotic antagonist
of long duration and to improve on the available drugs. Funds are
available, and should your enthusiasm not flag, I am confident
that we can build as strong a program as your energies will allow.

best

I am up to my eyeballs in work; and on top of it all, am
planning to return to Europe on September 21 for two or three
weeks. Our projects in Athens are doing very well; and the work
will be expanded to Jamaica this winter. I look forward to your
joingng the group-- I now have four fine co-workers in clinical
programs, and three experimentalists-- my best group ever.
Our

best to Betty.
As

ever,

�</text>
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                    <text>'mv’tryu;

September 10, 1971
Dr. Ralph Jacobsen
Endo

Laboratories

Garden City,

New

York

Dear Ralph,

I

subjects

am pleased to enclose
who received naloxone

the case summaries of nine

in oral doses above

200 mg/day,

received doses to 3,000 mg/day. We
including subjects
have requested the complete hematologic profiles obtained by
Dr. Lerner and his staff, and these are included.
who

present study program, using naloxone concentrate,
is underway. Dr. Zaks has screened a number of applicants, and
these are now in their periods of detoxification and medical
examinations.
The

pleasure to see you in Washington last week,
I look forward to the development of both EN 1639—A and
naloxone pamoate, as both compounds seem to hold much promise for
the eventual solution of the problem of opiate dependence, not
only in our soldiers in Southeast Asia, but the many patients
in our ghettos as well.
and

It

was a

Thank you, again,

for your support

and enthusiasm.

Sincerely yours,

‘
.,

.
221-,

.£~mvﬂwmnﬂ‘mn-vr:

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Spetember 12, 1971
Major John O'Brien
23

Inf. Division

South Viet—Nam

Dear Major,
Your story in the New York Times today prompts me to write
to you, and to send you the enclosed report of research in the
treatment of opiate dependence, as these data may be useful to

Since this report was written, it has been possible to
induct more than 40 patients into cyclazocine therapy without
any side effects in 4 days, by combining two of the drugs
listed here, cyclazocine and naloxone.
you.

It

my contention since late Spring when the
of
the
crisis in heroin use in Viet-Nam reached
first details
the prophylactic use of cyclazocine and
that
our newspapers,
naloxone, given daily to troops in an andemeic area, should
provide protection against drug abuse, in much the same way
that the daily administration of atabrine was useful during
an earlier war in preventing malaria.

has been

These data have been submitted to the Department of
Defense and the recommendations have been made in the New York
Times. However, both the DOD and the new office of the President
are unwilling to risk the problems of a trial in Viet—Nam. To
undertake a test study, they say, would be too expensive and
too difficult, and would not receive the support of the field
commanders._

Should these data interest you in your efforts, perhaps
inquiries from the field may Spur some trials.
Good luck

in your efforts

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry
P.S. Should you doubt my credentials, please know that I am
a consultant to the FDA, to various industries, and was
Captain, MC during the second WW.

�</text>
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                    <text>September 12, 1971
Dr. Franz Josph Kuhn

Boehringer-Ingelheim

West Germany

Dear Dr. Kuhn,

data of the GPA—l Dopa study is still being
analyses are completed and these show some
effects for l-Dopa but more for GPA. The l-Dopa effect is
probably not significantly different from placebo.
The

analyzed.

promise

The EEG

The boys

it

are

now completing

the behavioral data, and

by the end of the next week.

I am writing today to clarify some points about my next
to
Europe. I plan to be at the allep EEG meetings in
trip
wurzburg, and had hoped to arrange to visit Ingelheim with
you, should this type of visit be useful to you in discussing
EEG analyses with your oo-workers.
Earlier this week, Dr.
Terry called to say that attempts were being made for me to
visit Munich and to hold some conferences in other laboratories.
While such visits are most enlightening and occasionally useful,
I do not have the time to go on the lecture trail during this
trip. It is necessary that I spend as much time as possible
in Athens and Amsterdam.to carry out my own work in these

cities.

For

this reason,

and since I have not heard directly from
planning to go from Wﬂrzburg to Athens. In the event that
a visit to Ingelheim would be potentially useful to you and to
my laboratory, I shall be pleased to arrange a visit on another
trip, as I plan to be in EurOpe on a few occasions during the next
six months (until my work in Athens 15 completed.

you, I

am

I will send the data and the analyses as soon as the boys
have completed the work.
my

best regards.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>September 12, 1971
Dr. Thomas Williams
VA

Hospital
Lake City, Utah

Salt

Dear Tom,

I have reserved space at the Dorado Beach Hotel in
Pnert Rico for the period April 18 to 21, 1972.

I

have not heard from Ottosson, and

been returned.

neither letter has

I will be away from September 21 to October 7, I
am troubled that I am unable to do much more until then.
In our conversation, I recall your saying that you will be East
about that time. Please arrange to visit me in New York
during the week of October 10. I think one day's work then
should get us flying.
As

Hope yau have settled in at Utah.
summary on Depression so much

Incidentally, I
that I am having
distributed to the resident staff. I trust that it is not
liked your

'confidential'

any longer.

Sincerely yours,
Hex Fink, M.D.

it

�</text>
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                    <text>"A

September 13, 1971
Dear Jon,
Two

One
One

it

Enclosed is the third paper for SeminaAA in Pbychiatny.
others are in final typing and should be out by the week~end.
is in fair shape and will have to go through another revision.
paper is still eluding me, and I will try again to extract

from

St. Louis.

._.».-,-

awn-rm

,Vnr'a",

I have asked three 'experts' to answer our questions.
set is in, the others should follow in a few days.
As

WM'W

.‘

'r

10 days,

return.

I wrote, unfortunately I will be in Europe for
but.should wrap it up within a few days on my

I heard that

you testified before Congress about the
you wish another 'expert' to appear,
be glad to do so. I had the opportunity to see him in action

Jaffe

bill. If

I'll

with representatives of industry regarding a development of
a long-acting antagonist, and was not particularly impressed.
v

r
-"

My

best regards.

U'VE'V‘

Sincerely yours,
"IV-\n,‘1-n'l,ﬂ'.?'ﬂ'

~17

0'

.arﬂ'vwwr‘v‘wa‘wﬂ

~mW§rw

mm:

Max

Fink, M.D.

One

�</text>
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                    <text>September 13, 1971

Fritz Freyhan,
Editor,

M.D.

Comprehensive Peychiatry
153 West 11 Street
New York 10011
Dear

Fritz,
I

am

pleased to enclose a draft copy of a report of

our experiences with multiple monitored convulsive therapy,
Clinical Experiences with multiple Electrooonvulsive Treatments,
for your consideration for Comprehensive Psychiatry.
We have been able to assess the clinical efficacy
and the effects on memory of unilateral electrode placements,
and these studies led us to multiple treatments. We have been

surprised that the clinical results of multiple treatments
is not much greater than one seizure—- suggesting that the
biochemical changes after one seizure are near maximal, and
that some development, in time, is necessary for the full
development of the changes which are the basis for clinical
results. The finding is similar to the observations with
antidepressant medications.
I believe the report will interest our readers.
my

best regards.
Sincerely yours,
Fink, 24.1).
Professor of Psychiatry

Max

�</text>
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                    <text>"-

-w

an»

w-.r&lt;y—,—.»n

unnrmmw

September 14, 1971
Mr.

Pierce

Immigration Service
20 West Broadway

New

York City

Dear Mr.

Pierce,

Following our distussion, I am filing the enclosed
B-l petition on behalf of Alexander Maurice DON of Johannesburg,
South Africa. Dr. Don, who received training in psychiatry
with me in St. Louis in 1964-65, has been invited by this
Department to join our faculty. His experience in psychopharmacology
equips him to develop a special program in the treatment of
opiate dependent veterans who are now being admitted to the

facility at Montrose,

York. Through our Dean's Committee
we have been asked to
establish the treatment program on a ’crash' basis, recognizing
the emergency nature of the problem as outlined by the

V.A.

New

affiliation with that treatment center,

President in June.

Dr. Don Besires to emigrate to the 6.5. The consul in
Johannesburg has indicated to him that no visa can, in due
course, be issued prio to December of this year.

It is our belief that his early arrival will permit us
to establish the treatment programs when they are urgently
requested. We do not have the personnel to establish this
unit, and have invited Dr. Don to do so.
We

would be

grateful for your assistance in bringing

this scientist to the United States.

will reimburse your office for the cost of cables
to Johannesburg pursuant to the authorization under this application.
we

Sincerely yours,
Fink, M.D.
Professor of psyciatry

Max

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                    <text>September 17, 1971
Dr. Russell Monroe

University Hospital
Baltimore, Maryland
Dear Russ,

letter.

A

combination of happenstances leads

me

to write this

episodic states/alpha
application for a study of me
by NIMH for an 'outside'
chloralose/EEG/psychopaths was sent to
hear, there were some questions
opinion. As you will undoubtedly
and I believe Dr.
by the committee about the EEG quantification,
Your

Shah

will call

you about

this.

the PRB-NIMH staff referred Dr. Michael
in a similar
Sheard of Yale University to me. He is interested
behavioral
EEG
and
problem, and plans to evaluate lithium, itsThe PRB sent him to
effects, in psychopaths in a reformatory.
systems to
me for the possibility of using our quantification
parallel to your own, and
assist him. His studies are remarkably
studies,
I took the liberty of telling him of your planned
He
enquired as to
suggesting that he contact you directly.
EEG
for classification,
the availability of procedures to use the of activated
EEG,
and I was able to review the whole problem
including your interest in alpha-chloralose.
well trained;
He is an interesting, bright, and apparently
and you should find it interesting to meet him.
David Paskeqitz.
As part of my review, I read the report by
he or you wish to visit us, it may be
It is good, and should
raises have been
mutually helpful. Some of the issues hehave
some data that could
examined by my associates, and we may
The same day,

make your

7143;.

4"???"

31‘?

My

efforts easier

and more rewarding.

best regards.
Sincerely yours,

km“:

.

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>September 17, 1971
Dr. Ronald Lipmao
FEE—HIM}!

5600 Fishers Lane
Rockville, Maryland

20852

Dear Ron,

visited mo thuraday, and I found his study
he is
interesting, his goals a-bitioua. To the extant thorn
and
intcraated
able
wa
are
interested in evaluating drug effects,
data
about
in helping him. I gave him detailed suggestions
recording, equipment, processing costs, and soot background
of the experiences of my laboratory.
Dr. Sheard

‘

In addition, I referred him to Dr. Russell Monroe who
has a similar project in Baltimore; suggested he consider the
use of an activation test (the alpha-chloralosa procedure, for
example) to classify his patients; and wrote a letter of introduction to Russ Monroe for him. Both men have similar processing
problems, similar quostions, and in this day of limited funds, their
working in tandem may reduce their coats.
With regard to the lactate proposal, I discussed your
call with Dra. Taylor and Abrams, and suggested that they call
you directly for specific ways that they can improve their
preposal. Should they wish to re~apply and accept your advice,

I indicated that

my

prior agreement

was

assured.

for your efforts on their behalfm
9r. Sheard to me. I hope I was helpful to him.
Thanks

and

for referring

Sincerely yours,
Fink, ﬂ.D.
Professor of Psychiatry

Max

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                    <text>Septemb a' 17, 1971
Dear Costas,

First, let me thank you for the cortesy and assistance
staff gave Dr. Volavka. He returned tired, but assured

you and your

that the studies will provide the data

we

anticipated.

I met Costas Miras and discussed the continuation of the
present studies, my desire to bring in some U.S. cannabis for
trials, and the proposed extension of the studies you suggested.
For the cannabis, he did not believe that a direct import license
would be as useful‘as a shipment via the W.H.0. in Geneva, and
indicated that he Would make the necessary arrangements.
I will be in Europe on Wednesday, and should be able to
Spend a few days in Athens. I am scheduled to arrive on Saturday
about noon or 1 p.m., and can remain until Wednesday morning.
Costas Miras said that he would be available , and I would
appreciate

if

we

could discuss the following:

1. The data of phase

I,

and anynhelp we can give you;

2. Phase 2, the specific protocols add timetables;

rent;

3. Equipment needed for part 2 (can you arrange to
he lend you some equipment; or, can you make your

may

tape recorder available);

4. Importation of U.S. cannabis, and the export of
your samples for our assay;
5. your proposals for a new contract.

I hope this agenda is agreeable. I have requested
accommodations at the Grand Bretagne, and would be pleased if I
can meet a member of your staff on Saturday afternoon to go over
the available data.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

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                    <text>7‘

:I;

”5!":W‘m-

‘”

"
2:
1.
r

2;

September 17, 1971
PD

Dr. U.

J. Jovanovic

Universitats‘Nervenklinik u. Polyklinik

87 Wurzburg
West Germany

Dear Dr. Jovenovic,
York on Pan Am Flight 100 on
Wednesday morning, September 22, arriving Frankfurt at
11:59 p.m. Wednesday evening. You have arranged for me to
stay at the Hotel Rebstock, and I would be grateful if you
would notify the hotel of my late arrival, and arrange

I plan to leave

transportation

New

if that is still feasible.

I look forward to the conference with enthusiasm.

“Wary“,vzﬂ:

‘wr'n-

2"

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>'-2

war-vlw'm

~w¢w

um..—

.
.4.

vv-u—I—vu-

5‘
Mar

w—w—w—w

‘.'.~“

w”...

mum-wuw

an,“

'frrr-

September 19, 1971

Dear Tom,

I have received a mott helpful and affirmative response
from Dr. Jan Ottosson, and I am.encouraged that we will be able

to carry out our goals.
w

1m.

See you about October 10.

«Wu

:vv

"r‘

—,'

«,.w«.gm\

Sincerely yours,

14-21-

:3«\

Max

(VF-wtmw—F‘V‘y

E

“M

;;
391‘»;

.&lt;

r'nﬁ'

.-

avg!

Fink,

24.1).

�</text>
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                    <text>.

w...

a'r&lt;'»"fF'.-,Immr77“l'n-r)

“

September 19, 1971

Prof. Dr.

H. M. van Praag

Psychiatric Univ. Clinic
Oostersingel

S9

Groningen, Holland
Dear Dr. Van Praag,

I look forward to joining you in Amsterdam on September
30. ﬂy present plans call for my arrival on Wednesday, September
29 about noon, and I have booked a room at the Amsterdam Hilton.
Any messages regarding last minute arrangements can be sent there.
Professor Alfred Freedman has elected to prepare and He
read the report on "Cannabis Psychosis' that you requested.
is scheduled to arrive early Wednesday morning on an overnight

flight

from New York.

In the cannabis discussion, should you wish it, we could
chronic studies in volunteers,
present the findings of our acute and
and
EEG
some preliminary data on
the
changes,
with emphasis on
Athens.
from
acnnabis
users
our study of chronic
manuscripts are not fully prepared, but should be
available to you by October 15 at the latest.
The

Again,

my

thanks for your kind

invitation.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>.

7“,.

em...-

W.

,,___ .vvwr _~_...__..... , "wave—”mp-.."

WWW..-

..

94% 7/

Ron. Paul Rogers
U.S. House of Representatives
Washington, D.C.
Dear Mr. Rogers,
You may recall that this laboratory has been in the
forefront of research in the use of narcotic antagonists (naloxone and cyclazocine) in the treatment and prophylaxis of
opiate abuse; and that we organized the 1970 missing on this
subject at the New York Academy of Medicine. I am writing to
you at the suggestion of Professor Daniel Freedman of the
University of Chicago, for I shared with him some of my doubts
about our present national effort, and he recommended that I

share these doubts with you.

September 8 meeting on new approaches to
the treatment of Opiate abuse organized by Drs. Jerome Jaffe and
Robert Rees of the special office of the President. That meeting
was a distinct disappointment, for the agenda was poorly prepared;
the chairman was clearly ambivalent about the approaches and
his interest in them; and the industry representatives were

I attended the

unwilling to alter their present committments, expressing the
that there was little more that could be done.

view

Your committee is reviewing the President's reqiest for
the development of a centralized approach to drug abuse. Such
an office could have some merit, were the officers available
with experience and knwledge to lead the national effort. The
preliminary suggestions for the control of abuse in the military;
their cavalier dismissal of suggestions for prophylaxis in the
armed forces; and their apparent mishandling of the problem of
narcotic antagonists makes me less than sanguine that the
President's request will serve a useful purpose. It is true that
the established agency for research, the National Institute of
Hental Health, his lacked leadership, but the approach of
a new office, with its own large staff and apparent inexperience
cannot serve a useful public purpose.
h
1. a “933i :5.1:“?og‘ﬁﬁztézr:3§1§°2%ngohhassle};ease,tags
is also probable
that naloxone is the drug of choice at present. It have
a distinct
naloxone
and
may
that a combination of cyclasocine
role in the present crisis in opiate dependence, particplarly in
h

�, .,.

. .

.

.w.»,-:..-.Wvn-“r-p-V awn”.- .m «an—~71

.rr-wrm—V~ﬁv-nTv‘r -,..

.

,

a confined population, as in the
treatment and for prophylaxis.

.

.

-“T—vr.w..,..«.

wrew...‘

military in

.—

W¢U&lt;

‘rr—wr

5w

mung—.7,“

Viet—Nai, both

~

u

—-

weww

v

for

the meeting, I would conclude that Rude/DuPont are
the efforts necessary to develop a long acting
antagonist. While they ascribe their difficulties to the practical
issues of raw materials, patents and limited staff, it is clear
that they have other issues of greater concern to them, and
their efforts in the area of drug abuse control are only the
minimum required to assuage public demands.
From

not able to

make

It is also my opinion that the leadership in the
President's office is also ambivalent, for they have not the

experience with the combination of naloxone and cyclzocine, as
well as having a public committment to methadone.
For these reasons, among others,

it

may

be useful for

your Committee to consider the special commission approac -a commission dedicated to evaluate the possible uses and
roles for the narcotic antagonists. Such a commission could:
.2

m'rwrsmﬂv

assure adequate supplies of naloxone for clinical
in
trials, part by alleviating the artificial quotas for the
raw materials, principally thebaine;

I

coordinate, finance, and evaluate clinical
and naloxone, particularly in prophylaxis

~

V-I'

studies of cyclazocine
in the military;

invite contracts for the development of a long
formulation
of naloxone— (our experience with a
acting
silastic polymer formulation of naloxone makes us believe this
approach to be feasible);
support studies of

antagonists; and,

new

provide an independent evaluation of methadone
and the antagonists in treatment.
rv-vwnm—t—w-u

w-rnwmvr

«aroma-w,

m

(
-.q.

"v“

w.

was»:

v

&gt;'rvrvr»raraul

Such a commission could

include

some

of the industry

representatives, called together at your request by the P.M.A.,
and some independent university members.
The President's interest in drug abuse is commendable;
the approach of developing a new office committeed to no
definite goal makes it likely that it will be less efficient
than a commission approach- even one designed as an integral
part of the existing National Institute of Mental Health
structure could be considered.

I shall be in

Europe

until October 8, but should

you or

interested in discussing these views further, I
your staff
shall be available thereafter.
be

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

:

�</text>
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                    <text>l9 September l97l
Arthur Sugerman, M.B.
Neuropsychiatric Institute
Princeton, New Jersey

A.
NJ

Dear Art,
has been a long time since we chatted about ECDEU
reading
affairs, or about stocks, and I was reminded of thisin in the
addicts
in
narcotic
on
recent
prazepam
report
your
Journal of Clinical Pharmacology. I found your report interesting

It

for it confirmed some of our observations with tybamate in a
similar group of subjects. We had tried to maintain patients on
tybamate during the post-drug withdrawal period, in the hOpe
thatbb tybamate would 'block' the craving for opiates and reduce
recidivism.

Unfortunately, our patients liked tybamate itself,
that
particularly when combined with alcohol. They reported
small doses of tybamate and small doses of alcohol acted

synergistically to give
can do

them a cheap

'high‘.

So far. there seems to be little more that we
for the Opiate dependent but reduce their symptoms

during withdrawal, or maintain them on methadone indefinitely.
the antagonists show these
still believe that our workwewith
have had difficulty in convincing
drugs to be most useful, but
the authorities that more efforts should be spent in this area.

we

My

best regards.

and

my

best wishes for

a happy new

Sincerely yours,
Max

Fink, M.D.

year.

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                    <text>19

September 1971

Dr. R. ﬂechoulam
School 03 Pharmacy

Hebrew University
Jerusalem

Dear Dr. Mechoulam,

Following our interesting discussions in New York, I
met with Dr. Bernard Loev and his associates at SKF, to request
supplies of SKF 5390 (EA 1476) and that either they or I file
an IND for studies of this compound in man. He has written that
they are unwilling to file an IND, unwilling to provide the
compound, or to support an IND from my laboratory.
He indicated that he expected you in Philadelphia
about October 11. Perhaps you could visit us in ﬂew York to

discuss this further

?

Interest in a long acting antagonist is all at the
verbal level in the 8.5. today, but if you wish to propose an
attack on the problem, it is altogether possible that funds could

be found by Dr. Freedman.
Have a

pleasant trip West.
Sincerely yours,
Fink, 3.9.
Professor of Psychiatry

Max

P.S. I will be out of the

U.S

until October

8.

�</text>
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                    <text>September 19, 1971
Dr. Leon Hellman

Montefiore Hospital
Bronx, New York
Dear Leon,
My thanks for your advice and help for Mickey Taylor.
returned from his visit enthusiastic about his work and
duly concerned_thst a proper evaluation of his questions
required support and facilities that were beyond the means of

He

our Department.

0n inquiry in our medical school, he was referred to
Dr. A, Louis Sothren, who has some facilities similar to
your own. He has discussed the protocol with Mickey Taylor,
and following your recommendations a protocol is being prepared

for

NIMH.

I have urged him to consult
grateful for your advice and help.
My best regards for a happy

you and continue
new

to

be

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>mum-war:
1'

"my

VAWU.MWW.W

.w—n-p—vrmw-

w
_

SepTember 20, i97l

._.wuwv.-mu.w

.

pmmwwv

MW

5.
w.

w.

awn

uw-ww

nwmvvv'

Dear KaThy,
am enclosing anoTher of The ECT papers. This one has
exTensive
revision, and would apprecleTe your help.
undergone
Please refype a clean draff, omiTTlng The Tables and references.
in The TexT, check The references which should be ciTed noT
as superscrist, buT ln ( ).
i

i

rv

When The

do 50. Send The
mnumpww

i

Dr. WalTer Essman

DeparTmenT of Psychology

Queens College -

Flushing,

“mg-”Wm,

v-u

drafT is compleTed, if your can xerox a copy,
original and The drafT which ediTed To:

New

CUNY

York

il367

Send The xerox To me.

if

you cannoT geT The Typed drafT xeroxed, send The
and
Typed drafT To Renee and she will send The xeroxed
original
To WalT Essman.

i'm leaving for Europe Tomorrow, and shall reTurn on
OcTober 7. Try To geT The drafTs To WaiT Essman in Time for me
To geT Them back.
There are

Two To

go, wlfh The deadline moved up To l0/l5.

Renee seems To be doing well, even amid The usual confusion.
have SpenT The lasT week in WashingTon, Kalamazoo, and Richmond;
and find myself in AThens, AmsTerdam, and Wurzburg nesT few weeks.
The flying is sfalied: would you believe ThaT if has rained or
been lFR every day in SepTember ThaT l have been home i
i

Keep George happy, and your

fingers flying.
My

love,

�</text>
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                    <text>F”

1...’

.r.“_._.e_m__.v...~w

twmwu—WW—t— ‘va-xmm vm—v

20 September 1971

Dr. 2. Taintor
462 Grider Street
Buffalo, New York
Dear Dr.

Tainter,

would be pleased to participate in the continuing
education program on November 6, 1971 on the subject of
Narcotic Antagonists in the Treatment of Opiate Dependence.
In the event that I am unable to pparticipate, Dr. Richard
Reenick of our staff will present our experience.
We

of

The
Max

report should be listed as

a

joint presentation

Fink, H.D., Richard Reanick, H.D. and Arthur Zeke,
Thank you

M.D.

for your invitation.
Sincerely yours,
Max

Fink ’ NJ).

Professor of Psychiatry

�</text>
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                    <text>V'—" —.

V

r‘w

.W—q“..- .

mp7. '..'~mvlw"-u'.

~wr-1-

um‘ wwm www.mm... m.—_____.,.__

v... v .__.__v

v

We _

.¢_~W--W..VMMVV,_

20 September 1971

Dr. Jon Heiser
University of California

Irvine, California

Dear Dr. Heiser,

that

I

Your experiences are most interesting, and
you are extending your studies.

am

delighted

In our assessment of the EEG changes with anticholinergic
drugs, the changes in the theta/delta (2-7 cps) and the fast
beta (22-30 cps) were the most interesting. We used a conventional
frequency analyzer in our studies, and confirmed some of the
changes with our computer analyses using period analyses. But
many years earlier, the same work had been done very well by
Romano and Engel in 1944 (AMM Arch Nburol Phyohiat.,51:356-377)
using hand methods. Should these prove too painful or expensive,
and a frequency analyser unavailable, we would be willing to
cooperate, should you be able to collect the tapes necessary
for our analyses.
most important measure would, indeed, be the EKG and
heart rate, and these could also be analyzed using some of the
available computer processing methods. But they can also be
done by hand and eye.
A

I

am

not clear about the 'csrdiovascular toxicity of the
have not been too impressed with the cardiovascular

tricyclics'. I

effects of our compounds except for thioridazine, which does have
clearly defined effects on cardiac function, and is interdicted
on that score in my units.
Hickey

is busy planning an extensive set of studies,

I am delighted to have him back. Give my best to
John Kramer (should he return from his infatuation

and
Elliott and
with the W.H.)

Bank

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

W”

_W. _r_.-wee_.

.v—w ..

m v»

�</text>
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                    <text>mm‘m—vm.

(’3’;

20 Sepfember l97l

Dear Jon,

Following our conversation,
The

I

Though? some more about

question of Joe Tecce. Enclosed ls

our recenf reviews of fhe penfofhal

diphasic response which
physical lines,

The

we

a

EEG

reprinf of

response. if shows

have lnferprefed along

In our

sfudy of amobarblfal and dexTroamphefamlne, assimilar curve was
in evidence, alfhough we chose To disregard fhe
and focus on fhe long farm

My

effects.

besf.

Wm."

l.

a

classical

operafion of a springnmechanism.

w

m.

one of

Sincerely,

iniflal changes

�</text>
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v...

w“...

.-

A

20 September

a-n-v-v-wwnwww-wn1—.mw~.v.u—-v-.~’-..-«.murmur—“v

ww.w.-rn

PD

l97l

Dr. N. Matussek

Max

Planck

Institute

Munich. Germany

Dear Dr. Matussek,
I have been asked by our National Institute of Mental
Health to organize a meeting on the general problem of the
biochemical and neurophysiologic data of induced seizures. in
man and animals, with specific reference to electroconvulsive
therapy. In discussing the work from various laboratories. some
of which may be unpublished, your name was suggested as one
to whom I may write for information as to work in progress.
I

work, or

would be

grateful for

any infbrmation regarding your

that of your co-workers. that is ongoing andmight

on the problem of electroconvulsive therapy in man. I
should be particularly interested in any preprints of your

bear

recent work.

spring,

The

conference, should

1972 in the United

Thank you

it

States.

be held.

is planned for late

for your reply.
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>~»—.a—v 'r-F'

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.

September

.
,

H

Dr. Fred A. Clark,

m,,..._.wﬂ.,q,..s..,w.n

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,.....y-,-

2i, l97l

Jr.

A. H. Robins Co.
l407 Cummings Drive

Richmond, Virginia
Dear Fred,

as,

,

have read the
andimin (fenfluraminei,
I

,vnmnmu’m

questions:

summary portion of the submission on
l6—6l8 (vol. 4.l) with the following

NDA

.m.‘

is the presentation clear and does

.»

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air")

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claims of the

the

the 'labelling' section present the data clearly and
concisely, sufficient the convince the examiner that the claims
for a new drug as 'safe' and 'effectlve' can be substantiated;
Are there additbonal studies that should be considered 7
impression is that the summary is written poorly; that
redundancy, leaving an impression of 'padding'; and
some important issues regarding anorexigenlcs are omitted (persistence of effects, tolerance, dependence, and similarity or
dissimilarity to dextroamphetamlne clinically). The summary is
complete and sufficient in demonstrating that extensive pharmacologlc,
metabolic, toxicologic, and clinical studies were done. Indeed, the
amount of data and number of studies are impressive. Yet, i can
easily imagine the text Inducing doubts. Some criticisms to be found

there is

in the

My

much

details are:
the

same

tables

inﬂate/‘9’"?!

v:

njaqw-

whole

1

,0,

it substantiate

Does

_

1125's.».-

NDA;

data is presented in a variety of ways;

do not present the

salient issues clearly;

sections appear as testimonials, diminishing the

merit of the data base; and,

,.
(a

”W

:r.

,rwmﬂa-a-yv

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words

some language is obtuse, leading the examiner to focus
rather than ideas.

on

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-2There are two types of data that seem to be treated less
adequately than one could wish. One issue in the use of the
anorexlgenlcs is the extent to which they inhibit appetite, reduce
food intake (or increase metabolism) to yield a gradual loss in
weight, and to do so safely. The criticism of dextroamphetamine
is the short time it is effective (7tolerance), its abuse
potential (?dependence), and the occasional toxicity expressed
as insomnia, irritability and tremor. (The same can be said about
other stimulating anorexigenics.) i find the comparison of
fenfluramine and dextroamphetamine incomplete. The tables on
pp. 28—33 are impressive but they lack clinical data. Perhaps
the two drugs should be contrasted as to stimulation, secondary
effects, abuse potential (has this been demonstrated or tested 7),
and dependence. Such a comparison could emphasize the unique
properties of fenfluramlne, make the labelling claims distinctive,
and allow for approval as separate from the anxiety occasioned by
dextroamphetamlne abuse.

issue is duration of effect. A principal
criticism of dextroamphetamine is a limited period of efficacy.
These data doeaot allow for a decision as to whether continued
use of fenfluramlne is associated with tolerance, or whether
weight loss is sustained. Are increasing doses necessary to
sustain weight loss 7
The second

v-yw-rw-r

("wuv

‘7...“ n-c

clear,

With regard to the labelling
and useful as far as it goes.

cited above, although these answers
labelling.

section, find
It is deficient
i

may

not

be

it

adequate,

in the issues

necessary for

opportunity to discuss the conclusions of the
committee meeting on anorexigenlcs with Elmer Garner and
Donald F. Klein. Both indicated that the agreement in the committee
i

FDA

had an

limited; that no anorexlgenic was really 'proven'; and none
sustained wieght loss. l enquired about the questions of tolerance
and dependence, and these seemed the principal anxiety in
approving new compounds. "Do we really need another drug to be
abused ?" l suggested fenfluramine may be significantly different
than dextroamphetamine, and Dr. Gardner seemed attentive and
interested. He said the FDA was about to allow an NBA for
another anorexigenic, and he expressed the opinion that there was
little reason to hold up an approval for fenfluramine.

was

My

separately.

specific

comments are attached. The volume

is returned

leaving for Europe and will return October 7. l have
dictated and typed these notes rather hastily, knowing you wished
a reply as eoon as practical. My thanks for the opportunity to read
these data, and i trust the submission will not fail. if i can
be of help at the FDA, l have no hesitation to meet with them.
i

am

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

,

7,.

..

,

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                    <text>October 21, 1971
Dr. Henri Gastaut
Centre Hospitalier at Universitaire de Marseille

Hopital de la
DD

13

Jean~Mou1in

- Marseille

Timone

(5

E

),

France

Dear Dr. Gantaut:

Enclosed is a short summary of the data presented at the
recent interesting symposium in Marseille.
Again,

we

thank you for your kind

invitation.

Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF:kt

enc .

�</text>
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                    <text>—

_,.,

,

7-»

W-.ww aw

~~..r.—w—~—~-...ﬂ

-

mr cup-u .v-q—

w—.

v”

.-,

,,

..._ l...

,

._

,

w

.0“

v

.7

.

W.

.

4‘.

...-

w-vv—M»

October 31, 1971
Dr. Jonathan 0. Cole
Boston State Hospital
Boston, Massachusetts
Dear Jon,

Enclosed are the
(1)
(2)
(3)
(4)

Also,

final drafts for the

Volavka

Theories

Fink
Fink and Abrams

Q

copies of Small and Small.

Note:

Abrams paper (clinical)
made on page 17.

Note:

Fink (theory) has page

I enjoyed the work. I

their standards.

&amp;

A

is included for the
S

of the citations missing.

hope the

editors find the material

Will follow tomorrow.
up to

volume:

Neurophysiology
Medical

Pitts

two

additions

ECT

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt
83¢ o

,

�</text>
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                    <text>OcTober 9, l97|

Prof. Alfred M. Freedman
Chairman, DeparTmenT of PsychlaTry
New York Medical College
Dear Al:
The following noTes are wriTTen in response To your
informaTion
for
as To my relaTionship wiTh L. Bucci, M.D.
requesT
l
firsT meT Luigi when
T0 The DeparTmenT, and his inTeresT
me To requesT his appoinTmenT To my

he applied for an appolnTmenT
in psychoTropic drugs allowed

division.

His firsT assignmenT was an evaluaTion of The
duraTion and poTency of fluphenazine enanThaTe compared wiTh
oral fluphenazine; and This laTer was augmenTed by a comparison
wiTh fluphenazine decanoaTe. As is our cusTom, we esTablished
a proTocoi for The admission of paTlenTs To The program, Their
supervision and raTings, and The Types of evaluaTions required. MosT
criTical in such evaluaTions, is The adminisTraTion of The
proposed dosages for The proposed lengThs of Time, wiTh The
physician allowed To use his judgmenT in each case as To The
From The very ouTseT, Luigi had
proper dosage To be deployed.
more difficulTy Than Two oTher TherapisTs (Maria Fuchs and Jovan
Simeon) in carrying ouT The proTocol. The dosages were more
variable Than ThaT of The oTher physicians; There were repeaTed
supplemenTaTions wiTh oTher drugs, parTicularly MAO inhibiTors
(despiTe proscripTion in The proTocol); and The records were mainTained in an idiosyncraTic meThod.
aT

LaboraTory TesTs were noT requesTed as required, and
various Times, The duraTion of TreaTmenT was suffciienle

aiTered ThaT The drug Trial Took
anTicipaTed.

many more monThs Than we had

AT The end of The experimenT, we noTed ThaT The
evaluaTion of secondary effecTs for Dr. Bucci's paTlenTs was aT
IeasT Two Times ThaT of The oTher physicians. On examining The

records and The available cases, we noTed a marked discrepancy
beTween The evaluaTion criTeria he used, and Those of The resT of
The sTaff. AfTer considerable review, l concluded ThaT The idiosyncraTic naTure of his judgmenTs was sufficienle differenT Than

�"nv -vw,mw&gt;n~ m-w—I—H—o-w

my

experience

To

‘iw_mwww.’.

--

mm w.wmmwwwvww i,”
TVWV

preclude his usefulness in

of The Division of Biological PsychlaTry.

The

ﬂ_»_r..i.,.._..........-.wv-

research programs

His opinions wiTh regard To The TreaTmenT of
MAO inhibiTors are based on sTudies which
he has published. i have read Two of These reporTs, and recall
ThaT They failed To saTisfy my criTeria for an academic reporT—They were deficienT boTh in conTrols and in independenT evaluaTlons.

psychoTic paTlenTs wiTh

In adleion, i am aTTaching a xerox c0py of a reporT
which he published from The work aT MeTropoiiytn HospiTai. i
do noT recall seeing The proTocoi filed or approved, and I
suspecT ThaT This sTudy was done conTrary To The rules of
The school. This, despiTe, my urging him To file The becessary
documenTs before a sTudy is conTemplaTed, parTicularly one
ThaT is as unique as This one.
On

The posiTive

side,

i

would

recall

To

your aTTenTion

his enThusiasm for Teaching and parTlculariy his drive To
asserT The posiTion of psychopharmacoiogisT To The DepaTmenT.
There was a disTincT dissoclaTion beTween his enThusiasm and his
abiiiTy, and for This reason, i requesTed his Transfer from The
research divisions and failed To supporT his requesT for
promoTion.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychlaTry

-

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              <elementText elementTextId="50293">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>Oclober l0, I97l

Springer Veriag

Berlin,

Germany

Genfiemen:
On my

re+urn from an exfended Trip

i

found +he

proofs of +he figures for the arficle 993 for Psychopharmacologia.
Anflcipafing fhe delay, i had refurned fhe qalleys earlier, and
am now enclosing the figures with fhe page of the
galley duplicafe
#0 which fhe figures refer.
i

lifies

have indicafed +heir locafion.

in prinfing The figures, The edifor has removed The
from each figure, leaving fhem unidenfifled. |+ ls
necessary

Thai +he figures receive +he proper idenfificafion:

l. Primary Baseline Cross Della (0-3.5

Hz)

2. Primary Baseline Cross Alpha (7.5 - l3.5 Hz)
3. Primary Baseline Cross Befa

(+ 40 Hz)

Firsl Derivaflve Baseline Cross
5. First Derivafive Baseline Cross
4.

Average Frequency
Alpha

(l0-l6

6. Firsf Derivafive Baseline Cross Befa (+50 Hz)
Thank you

for your cooprafion.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Hz)

�</text>
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                    <text>-

October l0, i97l

mey-wy.

wan—wt

«‘

my":

HIP."

Dr. E.

W.

Gill

Oxford, England
Dear Dr.

Gill,

at the
suggestions that
there were many acive ingredients of cannabis and the evidence
presented was of great interest; as was the data on the variety
of contents of the constituents of cannabis from specimens from
different parts of the world. As Dr. Freedman mentioned, we are
involved in comparing the effects of cannabis in Athens and New
York, and your presentation would be of special interest to me
I

Dutch

and

very

much

enjoyed your presentation

interdisciplinary society meetings.

my

such is

The

associates.
May

available
Many

l

?

prevail on

you

to

send us a

preprint

when

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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\- -.-

w-.r..v—r-&lt;V"Ww—nwi’ﬂ'w4_.m-.—w.w_—.—.mn_——-uvrw.w~....... F"..—

.n

W...

_

w

-H

w e- ”7—. “m"...

...,

.

.e......._.._v~

.V.

a.

.7

'va-‘W

”w.“

October 10, 1971
Gerald Klerman, M.D.
Massachusetts General Hospital
2

Fruit Street

Boston, Massachusetts
Dear Gerry,

I

am

Dr. Richard Abrams

ical Association.

writing in support of the nomination of
for membership in the lbericsn Psychopatholog—

Dr. Abrams served his residency training at the
York Hedical College. After one year, he was inducted into
the armed services and during his tour of duty, undertook
independent research studies into ECT. He designed and completed
two studies of unilateral and multiple ECT in the treatment of
acutely disturbed depressed and schizophrenic servicemen. His
experience provided the basis for more extensive studies at
the College into the mode of action of ECT, studies hhich he
has carried ott during the remainder of his residency and
subsequently, as an instructor in our Department.

New

has written extensively in ECT; and is now
studies of new drugs in mental illnesses; the
in
participating
of
trial penicillamine in schizophrenia; and the evaluation of
He

war—ru-

as»

w-

n»...-

qvnnr-sW-wwqw

infusions of sodium lactate as a model of induced anxiety. He is
a serious student, well liked by his patients and the staff, and
is an avid reader of the psychiatric literature. He is able
to formulate projects and understands the principles of design
He is one of our outstanding trainees and I
and controls.
am pleased to recommend him for membership in the APPA.

‘n‘w

“a.

v

Sincerely yours,

w—m:

m

«5:-

x
1w.

J-E'l'm-MIR‘

M.—

.

Fink, M.D.
professor of Psychiatry

Max

e 7...

�</text>
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                    <text>V'W'wn-ﬂ‘mmwm

ywr'w

M.

.

y.

”7, w. -w. “NV—”Wrm‘w-vr:w—.,w~.w-—m w.-.._.mw—W~am—ﬂ-Tv—w7......» m‘\-r‘——— wee—W.
»

w. ‘

7-...r__-.._ _,_, .7-.__.._._ _._r,_. . s..._... W
‘

w

V

October 10, 1971

Dr. John Bergen
Chairman
Membership Committee

Society of Biological Psychiatry
Dear John,

I am pleased to nominate Dr. Richard
in the Society of Biological Psychiatry.

Abrams

for

membership

Dr. Abrams is a (nil time member of the research staff
of this Department and has been an active leader in our studies of
Convulsive therapy both during his residency training and as
a memebr of the clinical and teaching staff.

After completing one year as resident, he served his
tour of military duty. During that time, he undertook independent
reasearch into the variety of modifications of electroconvulsive
therapy, including multiple treatments in one session and unilateral
electrode placements. His work served to establish the parameters of
these treatments, and he is now responsible for this clinical program
in the Department.

is studying the effects of penicillamine
role of lactate in the precipitation of

In addition, he

in schizophrenia

and the

anxiety.

He

is an industrious

of the scientific

and serious worker, an avid reader
and an excellent teacher. I am pleased
membership in our Society.

literature,

to recommend him for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

,

�</text>
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                    <text>.

a».

my

1"

u,—w&gt;‘-(w—"‘

October l0, I97l

.m.

w

m.-

"WW.

Z 3856
New York

Times

v.—(——-’-wv_——r.,

Dear Miss,

w...

n.

......

.7

m"-

.7

v

secretary of six years has left following
am seeking a competent secretary/
The Division is involved in the
receptionist.
typist/
development of new treatments for the mentally ill, with
special emphasis on drug abuse. The secretary acts as the
administrative assistant for a large staff, assuming authority
for expenditures and various services in my frequent absences.
My

her marriage, and

I

The work includes the maintenance of some records,

.»

"—n—uwnr—

allocating charges to various research funds, handling some
finances, and typing of reports. Most imperative, the position
requires someone with judgment to accept calls and allocate them
to the appropriate scientists.
if the position interests you, please call me at
2l2-

369 8488.

u'm—

‘K’F—W

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

l

l

l

l

l

E

�.—

.mww

J..."

m

.,

~mm

~‘m'rVn-r ~m‘mwV—mm

'vr-‘vsw

October l0, l97l
Z 6i22
New York

Times

Dear Miss,

Recenfly, my secrefary/ adminisfraflve assisfanf of
six years ieff affer her marriage, and am seeking a replacemenf.
The focus of our office is in The deveIOpmenf of new mefhods
fo freaf drug abuse and various ofher psychlafric problems.
i

secrefary is responsible for managing fhe office, felephone,
and considerable fyping of reporfs and pubiicaflons. There is
some lighf bookkeeping as if is necessary fo keep some
check on the expendlfures of various sclenfisfs in +he program,
and There are five fo eighf accounfs open af any Time.
The

The

office is at

if such
af 2i2-369 8488.

a

i02 Sfreef and

Fifth

Avenue.

posifion lnferesfs you, please call

me

“W...

W.

Sincerely yours,

y.

a,»

~;———-~r,1-..—,

-\

Max

Fink,

M.D.

Professor of Psychiafry

�</text>
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                    <text>Oc+ober l0, l97l
Dr. Glullano Dolce

E. Merck A.G.
"v

'F

Frakfur+ers+rasse 250
6|

Darmsfad+
Germany

Dear Dr. Dolce,

0

wmr

before

I

Dr. K. Offenloch was klnd enough +0 call me
Jus+
had +0 leave WUrzburg and +ell he of
your ln+eres+

ln +he quan+l+a+lve programs for

EEG
of drugs. On
re+urn +0 Frankfur+, +he +lme was analysls
+00 shorf +0 allow us
+0 mee+.
my

am enclosing a reprlng descrlblnq +he
+heore+lcal
basls for our s+udies, and a progress repor+
wrl++en some mon+hs
ago +0 glue an apprecla+lon of +he +ypes of s+udles we have found
ln+eres+ing and feasible. These lnclude +he lden+lflca+lon
drug proflles, deflnl+lons of bloavallabill+y, and some doseof
I

comparisons.

l

+rus+ +hese are helpful and would be pleased +0

hear fur+her of your in+eres+ ln +hls problem.

Slncerely yours,
Max

Flnk,

M.D.

Professor of Psychla+ry

�</text>
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                    <text>chober l0, l97l
Dear irv:
For a number of years
have been unhappy wifh fhe
of
performance
Mildred Hill on my service. Early fhls year, her
absenfee record was so bad, and her performance when available so
confrary fo fhe aims of fhe program fhaf discussed her
performance wifh her. l received no saflsfacfion and Then
referred fhe maffer f0 you.
I

I

You suggesfed fhaf
speak +0 Mr. Torres, which
did do; and he assured me fhaf he would have her reassigned fo
anofher division, if indeed he was unable fo discharge her.
l

i

fold

in checking on fhe

leffer

from fhe Afforney General,

sfaff fhaf Miss Hill sfill is
involved wifh our oufpaflenfs; fhaf her affifudes are sflll
referred fo as confrary To our program goals; and fhaf she has
l

was

by fwo members of The

been known fo voice public concern wlfh our experimenfal
programs.
Wifhouf going info fhe merif of her compefence as
a counselor (a compefence fhaf has nof been demonsfrafed in 5

years of associafion), do believe fhaf her affifude fo research
problems is defrimenfal fo fhe successful complefion of our
projecfs; and on fhis basis, again requesf fhaf she be separafed
from my service, complefely and immedlafely, for the good of fhe
I

service.

lany

fhanks.Max

Fink

�</text>
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                    <text>F

._...

M.— .._

,

.7-......._. w -.

.

r

we,“

Him“...

...,... w.

...._._.W...,.,,...r.w..._..._.._.._..-~..e.- w w... ,, he-..

WW..-

-h.-.,,..___

-__,

W

”at... in"... _,_._.__,._,n_......~.MW-

” _._.i.._

“WWW...“ t__

October 10, 1971

9

..

V

mm..-

“rum—v

Dr. John Bergen
Chairman, Membership Committee

Society of Biological Psychiatry

WW

Dear John,

I am pleased to nominate Dr. Michael Alan Taylor
in the Society of Biological Psychiatryﬁlﬂinner,_uith
membership
for
Dr. Robert Levine, of the 1969 award of the Society, his work needs

little

introductionéj

resident physician, he was most industrious and
undertook independent research into the concomitants of post—partum
schizophrenia. Demonstrating that the sex of the offspring bore
a significant relation to illness in the mother, he subsequently
demonstrated that hormonal effects operated concurrently with the
ataractic properties of drugs-— a conclusion derived from his data.
As a

During his residency, also, he carried out independent
of the lactate infusion test for anxiety neurosis, confirming

verification
the work of Pitts

and McClure.

Since returning from military service, he has established
of
independent studies at Metropolitan Hospital, in
a variety

anxiety and in schizlphrenia.
I

am

pleased to

recommend him

for

membership.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>v--,-—.‘ «v—

,.mmm

__

._...

“.mm.

OcTober l0, 197|
Dear Al,
i

should like To recommend Richard Abrams for

membership in The formulary commlTTee of MeTropoliTan HosplTal.

years ago, aT your requesT nominaTed Richard
Resnick; and iaTer, asked Mrs. Cruzado To lnviTe me To dome
Some

I

I

of The meeTings.

These are held aT irregular lnTervals, buT The
is responsible foo The assay and deTermlnaTlon
of Those psychpharmaceuTicais ThaT are To be included in The
formulary, eiTher on a perminenT or Temportry basis.
CommiTTee

i

believe

ThaT Dick Abrams

is well qualified for

This posiTlon and considering The years ThaT Dick Resnick has
served, lT would be To every one's advanTage To make This requesT.
Thanks.

Max

Fink,

M.D.

�</text>
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                    <text>rvt'muwl

M-mw.m“\mvm‘§w’

,—

-

nw—uv—mmmwmm—w—w- m"wmr—V'-v

OcTober l0, i97|
Dr. PeTer Geerlings
Academisch Ziekenhuis
AmsTerdam

Dear Dr. Geerlings,
Thank you for your kindness in
the Cosmos Club. IT was an unusual experience,
inTroduclng
and The slghTs were more poignanT Than The descripTions inconr
liTeraTure. lT was anxleTy provoking To see so many young people

FirsT,

I

wanT To

me To

indulging in whaT was apparenle a wiThdrawal phenomenon. ThaT
Their elders did The same wlTh alcohol dld liTTle To miTigaTe
The impression ThaT They were induging in a public phansasy world.
i
was mosT sTruck by The young

Than

girl

from Chevy Chase, Maryland.

as iT may, perhaps your soluTion is much beTTer
ThaT of sending These young people To prisons.

Be ThaT

ours--

On my

llliciT drugs

reTurn

i

found your

on my desk, and
Taking an imporTanT sTudy.

SeparaTely,

I

am

i

arTicle

musT

on The

analysis of

congraTulaTe you on

under—

sending you our laTesT summaries.

i

believe These will be disappoinTing, since They reflecT The
usual academic sTudles, so far from The reallTy of The Cosmos

Club.

My

besT regards and

my

Thanks for your kindness.

Sincerely yours,
Max

Fink,

M.D.

Professor of psychlaTry

�</text>
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                    <text>October 12, 1971

Dear

Irv,

Dr. Harold Escover was a student of mine at Hillside
After I left he assumed responsibility for the
training program. With the reorganization at Hillside and his
remarriage, he now seeks work in New York City.

Hospital.

He

him highly.

is a diligent and serious worker and I can recommend
If he can work withing our program, perhaps you

Ihoﬁid see him.

Mex

Fink

�</text>
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                    <text>Prof.

October 12, 1971

R. Mechoulsm, M.D.

Laboratory of Natural Products

The School of Pharmacy
The Hebrew Uhﬁversity of Jerusalem,

Faculty of Medicine

Dear Dr. Machoulam,

I can be reached at my home, (516) 466—5444 on the
weekend of October 23rd and 24th.
.,.

”.1“:—

5w

;.

I too was surprised at the response of SKF.
you can do something to change their mind.

Perhaps

"prmp‘

I

7”

'."‘"{‘

do hape

that

you

the long acting antagonists.

will be able to

do something with

Sincerelyﬁyours,
a.
A

f’c'f'ﬁw-

"Jr—1

"‘

'V’Sr‘

,,

gala.

awry-z

“‘71

(7
pr;

'(Vp'

2.-

19.1355»!

s

.;1'/,&gt;r.

6,9"

‘
njrwt

Wt.

mna’mi‘w:

7"Hl'pefit'i-é

$57."

7.va

v.20

Fink, M.D.
professor of Bsychiatry

Max

'ﬂﬁhﬂ“,‘.~;v*

MF:jb

�</text>
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                    <text>October 12, 1971
Ralph Jecobeen, M.D.

Deputy Medical Director
Endo

Laboratories, Inc.

1000 Stewart Avenue, 3
Garden City, New York 11530

Dear Ralph,

thanks for your contribution to the programs of the
College. We will use the grant to buy some equipment which
we sorely need.
Mnny

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:jb

�</text>
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                    <text>October 13, 1971
Dr. Monique Broude

NIMH

5600 Fishers Lane
Rockville , Maryland

Dear Monique,

I am writing to request five (5) additional grams
of diacetylmorphine (heroin) for our studies of the duration
of induced cross tolerance of 1-alpha-acetylmethadol and
methadone. These studies continue our evaluations of these drugs
under

FDArIND

6825 (methadone) and FDA-IND 6590 (1—a1pha-acetylmetha-

dol). In both these studies, heroin is used in the ”heroin
challenge” model (see reprint attached). we use single doses
of 25,50,and 75 mg heroin at 24,48,72, and 96 hours after a
dose of methadone or l—alpha—acetylmethadol to establish cross
tolerance.

These stddies are part of our NIMH study program, ”Opiate
Effects on Brain Function and Behavior", MB 19476, and a copy
of that protocal is enclosed.

I

also enclosing the appropriate BNDD drug request
I hold BNDD registrations AF1732103 and PF0024555
for research studies.
am

forms (2513).

le would be grateful for a renewal of our supply
of diacetylmorphine (heroin) for these studies.
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>October 14, 1971
Dr. Sidney Malitz
Chairman, Research Commission

NYS
New

Psychiatric Institute

APA

York City

Dear Sid,

It

was a pleasure to discuss our common interests, both
en route to Europe and in Amsterdam. Also, I want to thank you both
for your help in the silver shop in the Rokin—— my daughter was
delighted with the silver stage, and I am not sure she will release
the Turk on the flying carpet to my friend, Turan.
With regard to your kind invitation to join the task
APA
the
force of
on drug abuse, I am pleased that the APA is
desirous of broadening the base of its experience. Unfortunately,
my schedule during the cominh year is overburdened by trips both
in the U.S. and abroad, and I will be unable to serve. A1 and I
have discussed the opportunity, however, and would suggest that
you invite Dr. Richard Resnick, Assistant Professor in our
Department, to serve. Dr. Resnick has been responsible for the
clinical programs in cyclasocine since 1968, and has the most
experience among our staff members. He is well qualified to present
our experience.

at

recommendation is acceptable, he can be reached
address, or by phone at 212 MO 2-1899.

If this

my

Again,

my

thanks and

my

regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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                    <text>rW

WW

__

_

WWW WWWWWWWWWWWV-.- WW -

October 14, 1971
Dr. Jonathan 0. Cole

Boston State Hospital
Boston, ¥assachusetts
Dear Jon,

Previously, I sent the reports by Small &amp; Small and
Dornbush. The Essman report was returned, and has been re-edited.
Enclosed are two copies each of the Abrams and the
reports. The Essman paper is better, but if it still is
unsatisfactory, please do not hesitate to edit it. I have
asked him to send me the glossy prints for his two figures and'
these will be sent with the next batch.

Essman

The reports by Volavka, Fink, and the Q 8 A are
in their final typing and should be done by Friday or Saturday.
I am distressed only about the section by Pitta-- he had promised
it two weeks ago and when I called him on Monday, he said it had been
mailed. Lost ? I hope not-- but he promised to send me another.

use, which

There

will

It

is also

an

come with the

introduction that I wrote for your

next batch.

has been fun, and I hope the texts are

satisfactory.

Sincerely yours,
Max

P.S. I cannot be sure-- did you ask
Dornbush and Smalls' reports 7

me

Fink, M.D.

to send you duplicates of the

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                    <text>wx-

~n,
~

me

"4““:

October 14, 1971

#"W~,

W‘Ac:

‘71.:-

7-7.0

Dr.
FDA

Barrett Scoville,

M.D.

Rockville, Maryland
Dear

Barrett,
I

am

writing in reply to your request for information

from our study of l-alpha-acetylmethadol (IND 6590).

are completing the data analysis for the two
groups of patients, 10 each, who received methadone (100 mg daily)
or l-alpha~acety1methsdol (Bx/wk). Three of the patients are
now completing their 4th month of treatment, and our evaluation
period extends for 6 months in each case.
We

initial

it

is clear, however, that
l—alpha-acetylmethadol is equivalent in every way on a 3xlweek
schedule to methadone-w in patient acceptance, staff awareness,
urine test results, duration of antagonism (cross tolerance) to
injected heroin, and drop out rates. Indeed, I am impressed with
the data, and have asked my associates to complete a preliminary
report for your use, as I believe that further testing of this
drug is warranted, both in the maintenance of patients, and during
the ambulatory withdrawal schedules now actively used in my city.
From

the

I believe

Committee and/or
My

group,

you should

SAODAP

alert the

Methadone Advisory

that such data is available shortly.

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

difference in our recent results from earlier published
results is in the dosage schedule of 70-70—80 mg.

P.S.

The

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                    <text>‘rwmwmw-w

v'

;
Vv'r:wvuv

av“?

—-——|v~mr-‘;mmrl

‘vo.VVIUV~.)

.957

-

.,,w

a

October 14, 1971
x:r-v

M’WIWVw-‘r

Dr. Joseph Wortis
Maimonides Medical Center
Brooklyn, New York

.'
«v—

Dear Joe,

I regret that we are unable to supply the manuscript
"Contributions of Unilateral and Multiple ECT . . .” The report
has been divided into two smaller presentations and are being
published elsewhere.
Thank you

for your interest.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

w
arr:

.

:-

'x‘rgy-g-jbgwwfrvgew

',-_'-

'.
"u"

MW

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                    <text>October 14, 1971
Dear Dr. Mechoulam,

I will be at

I received your itinerary after your
my

office all

day

letter.

in Thursday, October

21

(212 369 8488), and I look forward to hearing from you.

Unfortunately, I will not be available Friday.

If you cannot reach
on Saturday (516 466 5444).

me

on Thursday,

I should be

home

‘

In Amsterdam, I heard some preliminary data to be
presented in Stockholm, and I believe that should be a very

interesting meeting.

I hope that you will be able to look into the

development of a long acting antagonist.
Good

luck

!

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.

October 15, 1971

‘

wrmwn

Dr. Louis Bozzetti
Deputy Director, NCMDA
Washington, D.C.

‘2"

m".

art]

Dear Dr.

"WW-1;.“

.

Bozzetti,

I returned from Athens on October 6, and have been
catch
to
trying
up on my work since then. In Athens, I found that
the team had examined 31 chronic hashish users, and were preparing
to examine an additional 20. The data is most impressive, and we
are heartened that an intensive examination of these men will

be

significant.

We

have, therefore, proposed to

NIMH

to extend the

study, and I am now preparing the documentation they requested.

For this reason, I am not planning to return to Athens
end
the
of November, or mid-December.
until
At this time, there is little that can be served by a
would suggest you visit us in New York and I can bring you
up to date on the findings. If you wish to observe some of the
subjects during their examination, perhaps it would be advisable

visit. I

to wait until the detailed examinations are in progress.
Come

visit again.
Sincerely yours,
Max

Fink, M.D.

professor of Psychiatry

'
'-‘

‘.¥WF‘T€W,TW

"
"NW-

'9

Tyler-“rm;

C .3

�</text>
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                    <text>r-

“.1:

.-.,,. "ma...“ V.“ v-‘Lz-r'v“?-'4

m.

avg-pr m...

..

V

”F“.

.

rﬁ_.‘wr._n “w“.v

,

.. .‘

w"-..

.

wt..." .

,,

..

_..

H.

”,9,

._,_.~,

mm

wwumﬂ—w

..

YIN.

I-«~."~

-mu

myv-r—f'rw-

.wpwvr"nr‘;»w

October 16, 1971

u
a

x
v

F’v‘w’ﬂvw"

"”W'w-z.

-

"vu-vwrv'r

WWII-as

Dr. William Bunney
Chief, Div. Narcotic Addiction &amp; Drug Abuse
National Institute of Hental Health

Rockville, Maryland

Dear

Bif,
The

scientist

at the recent meetings in
H. O.

who

presented an interesting report

Amsterdam was

J. Collier

Miles Laboratories
England

(I regret I don't have a better address)
His

presentation was titled

Analysis of Drug Dependence"

"A

Pharmacological

.

I look forward to joining the discussions

on the 28th.

‘

.nzwrrr'urmm

Sincerely yours;

-

WWK’H,T'

Max

Fink,

M.D.

Professor of Psychiatry

,7

a.

m».

——.

,

”mus“!

.

v7,

‘

�</text>
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                    <text>October 19, 1971

Prof.

H. M. van Praag

Groningen, Holland

Dear Dr. van Praag,

First, let me thank you for the opportunity to
participate in the fine symposium of the Biological Society
earlier this month. You are to be congratulated in arranging
such a fine discussion and enthusiastic audience.

Dr. Freedmen will write separately, I am
you that both reports, on heroin and marijuana,
are now completed and require the final typing and editing. THe
two drafts should be completed by October 27 and should be in
your

writing to

As

tell

hands shortly thereafter.

to

new York

until last

up on my work.

I regret the delay, but I did not return
it has raked this time to catch

week, and

'

,Incidentally, Dr. Geerlings was most gracious in
arranging a trip for Dr. Petersen and myself to visit the Cosmos
Club. This was a most interesting experience and we are most
grateful for the experience.

visit to

New

Please let us know of the dates of your forthcoming
York, and we should be honored to arrange a visit.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>October 20, 1971
Dr. G. F. Blane

Reckitt

&amp;

Colman

Danson Lane
Hull, England
Dear Gary,

is our application (finally) for support for
research. I an optimistic that this will gain approval,
particularly since my government is showing special interest in
the narcotic antagonists.
I have received the note regarding change in shipment
route for M—99. I called our BNDD and am assured approval
has been sent to the British Home office and to Reckitt
Enclosed

MrSOSO

and Colman.

I enjoyed meeting Dr. Lewis. You may tell him there have
been additional meetings of the FHA Committee on treatment; and
NIMH has appointed a select committee to
plan research in the
antagonists. Its first meeting is October 28.
Thanks again

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:kt

�</text>
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                    <text>October 21, 1971
Dr. Daniel X. Freedman

Chief Editor
Department of Psychiatry, Box 2011
University of Chicago,
950 East 59th Street
Chicago, Illinois 60637
Dear Dan,

are enclosing revised versions of our report "Unilateral
ECT: Effects on Depression, Memory and the
Electroencephalogram". we have redrafted the results section,
following the cogent suggestions of the reviewers:
We

and

Bilateral
(1)

found the

patients responding to drugs instead of ECT?
difference in clinical effects between unilateral

Are

We

and

bilateral treatments to persist after statistical "adjustment"
by regression analysis - and have described our data more fully
on page 8.

our

(2)

own

Are

differences

suggestion (P8.

due to age or not? we try to answer
on page 12-13. We were unable to

11—12)

assert that age was a contributing factor to the clinical difference
in unilateral and bilateral HOT.
(3)

Confusing pages

8—9.

restructured the presentation -

Critic is correct,

we

issues of this study are important, and
to contribute to the discourse.
The

Again,

my

and we have

believe more clearly.
we

would be pleased

thanks for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Mszt

�</text>
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                    <text>October 22, 1971
Dr. F,

J.

Boehringer
Ingelheim

Kuhn

Dear Franz,
Dr. Stockhaus has written, requesting naloxone
for his research into the narcotic antagonists. I am
pleased to enclose a supply for his use in animals.
powder

..
v,
,.

“q...

..

I have not had the time to review the report on
but as soon as I can see the top of my desk, I will
get a copy for you.
l—Dopa,

-

I hope our meetings were helpful.

.‘.,

..

“Neurm,”

My

best regards,

and Happy Hunting

!

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

-4

,A

,1,

.

Jimmy-vr-w-«ww—a—mr

r.»
,——
-

Mair-2r"

Twmn-hx‘wjﬂ

Mp4»-~M-,i-

7,.”

, ..

,

,

.L, #,._.V -zﬁ 7,77,; .w"
-7

,

k

.,

-,.

,

,

.-.—,-.-..n_-:«. M» ~_.

�</text>
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                    <text>October 22, 1971
Dr. K. Stockhaus
C.H. Boehringer Sohn

Ingelheim

Dear Dr. Stockhaus,

Enclosed is a supply of naloxone powder, for your
use in animal studies, in the development of other narcotic

antagonists.

Good

luck.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

‘

(
"r

V‘A‘w’xI4l'.‘

w...“

7;.

mar:

.
.

,

mirr‘anv‘

Twp-nu-

�</text>
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                    <text>v.

zen—m.»

*x-n’V‘

-—~xv.g-g.v.r~«,

.—

—.

9"».

A
-

October 22, 1971

w.

Dr. William Tabor

army-warr—v-r-wp-

A. B. Robins Co.

Richmond, Virginia
Deer

Bill,
I have asked

my

assistants to transcribe the data
is some

1118 experiments on the forms provided. There
ambiguity as to whether a form should be provided for each
from the

AER

experiment, or for the variety of experilants for each subject.
I have enclosed a xerox copy of one record for your review. If this
is satisfactory, the data sheets will be prepared for shipment.
If you prefer another format, please advise.

for your kind hospitality and
understanding during my recent visit. Also, I very much appreciate
the description of the use of doxeprem in heroin overdose. It will
be made available in my clinic and we will test its use for our
Thank you very much

problems.

My

best regards.

'

ren—

Sincerely yours,

.

‘im'VIJ'T‘V‘qu‘U

Aux

Mex

Fink, M.D.

Professor of Psychiatry

v.

-r:'u

mauww

\

�</text>
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                    <text>w.

‘Wv

.._—W..~—w_v— w. av“

pwuww‘F-i'w‘y-w .,~.:- up»... V'. n: ,u. x" .....m .— -

W

v. h. WW...n

Dr. G. Dolce and K. Offenloch
E. Merck

V

L.

A

..
wmv
a .r,

7

.m. “a.-.

.. ».—. ,v-

m

--~-—..w.~w...—Wa". r. vw.-~.,.-.-_._....-m-r

.

um manw—rv—WV—u

October 23, 1971

Darmstadt, Germany

Dear Drs. Dolce and Offenloch,

I very much regret not receiving your telegram, for I
did have the chance to return to Frankfurt, but only for a day. I
an interested in visiting your laboratories, for when I was in
Ingelheim, I enquired about your programs, and was told that they
were among the best in Germany. .It is probable that I will be in
Europe again before the end of the year, and I should be pleased
to accept your invitation at that time.
In the interim, I am enclosing a preprint of a progress
report written a few months ago about our ongoing program; and a
reprint which describes our theoretical views. Perhaps, these will

be of some

interest.

My thanks for your kind invitation and
the communications were unsuccessful.

my

regrets that

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_—.—.W..—v

m—w...

wuss,” ..

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                    <text>w—u—qu—p.‘w‘V-uvw—v$wa~yrﬂmuww

.wr-

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WW1

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October 24, 1971
g

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Michael Sheard, M.D.
Yale University School of medicine

New

Haven, Connecticut

Dear Mike,

it

I have read and re—read your proposal, and find
am not fully acquainted with the status of research into
the treatment of psycopathies, but this proposal has both clinical
and theoretic interest, and should be acceptable. More important, it
should add some solid information to the problem of the relation of

quite

good.

I

brain function to behavior.

it

My suggestions are few:
would be important that
you become better acquinted with the Monroe methods and to that
end
would be useful for you to either try some alpha-chloralose
activations, or to visit his facility and watch Monroe, or both.

it

Secondly, since there will be accurate monitoring of the
blood levels of lithium, there is an interesting problem, that of blood
levels of substances and their relation to the EEG effects, to which you
can contribute. Should you condider taking a blood sample at the time
of the EEG, the value of that measure could be compared to the EEG

values (changes).

application is deficient in not noting the many reports
changes with lithium that have appeared. I recall reports by
Mayfield and Brown (J. Psychiat. Res., 1966), Pfeiffer (J. Clin. Pharmacol.
1969), Platman &amp; Fieve (Br. J. Psychiat, 1969), and more recently, reports
by Johnson, Gershon and Korein, and by Itil-- the citations are not
available to me. In none of these reports have the relation between
drug effects and behavior been verified, and this deficiency is related
in part to the inadequate quantification of the EEG and to the incomplete
nature of the behavioral and blood level studies. I would also suggest
you review the recent V.A. report on blood lithium levels and behavior,
of

The

EEG

edited

by Prien and others

at Perry Point.

As I mentioned, we are prepared to assist you in the
recording of the records in a way that would permit quantification with
the techniques available to us.
My

best regards

and

best wishes.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>”.manrm

Mr.
New

V...

Mr. W...

.mm

Jerry Finkelstein

warrw

was"... 1-...

.,w~»-wwm.vw

M...

"We“.w—‘v

inn—”.7

.

VWIVw—www—waw"

—w-F

October 24, 1971

York Law Journal

258 Broadway

New

York 10007

Dear Mr.

Finkelstein,

I recall clearly your article in the New York Times
total response to the drug abuse epidemic, and am
heartened by your announcement today that the New York Law diurnal
is planning asspecial issue devoted to the drug problem.

calling for

a

Beginning in 1966, we have been investigating the
of
using narcotic antagonists in the treatment and the
possibility
prophylaxis of ipiate dependence. We have been successful in demon~
strating that two antagonists, naloxone and cyclazocine, are effective
in blocking opiate use in man; and in beginning the work needed to
develop a long-lasting delivery system.
There have been many problems in this approach, most
noteworthy being the shortage of drugs for testing. In June, 1970,
in conjunction with the National Institute of Mental Health, we
arranged a meeting of the principal scientists working with these
drugs, and the conclusions of that meeting included the recommendation that further study was warranted. A summary of those proceedings
is published in Science, 192:1005-1006, 1970.
In the past few months, important steps have been
taken by researchers to clarify the role of these drugs and to
extend the number of institutions capable of testing these compounds.
In an issue projected for publication, it would be
valuable to have a sober statement of the data available, and the
projected uses of these interesting agents. I would suggest that
you reach the chairman of the Department of Psychiatry, Alfred M.
Freedman, should you wish a more sober and optimistic appraisal than
that usually emanating from official sources in the nationss capitol.
In addition, I would urge you to review the latest
information on the limitations of methadone, and the possible
advantages of a long acting derivative, l—alpha-acetylmethadol.

Sincerely yours,
Fink, M.D.
Ptofessor of Psychiatry

Max

m-vuvw—U—Cu

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Mr. Arie de Kool

J.

Martens
Natuur en Techniek

Th.

M.

Heerien, Netherlands
Gentlemen:
honored by your kind invitation to participate
in a symposium on drugs of abuse, and should be pleased to write
the article you request on the problem of the opiates. it should be
feasible to describe the social issues in opiate use, the clinical
pharmacology, physiological effects, and present modes of treatment
and prevention. You should be aware that our approach to treatment is
I

am

conventional principles of medical
treatment and not relying on simplistic social approaches.

idiosyncratic, being based

on

The main problem in accepting the assignment Is the time
to carry lt out, for I am heavily committed during the next two months
and would not be able to begin before the end of the year. if a delivery

date about February

for

As

i

my

is acceptable,

it

other suggestion,

is possible.
i

am

particularly interested

in the role of brain function in the treatment of mental illnesses.
Using the EEG, particularly in highly sophisticated quantitative analyses,
we have determined that the mode of action of psychotropic drugs lies
in their effects on the brain, and hence on the changes in brain function
(EEG) that they excite. Most of the psychotropic drugs have unique
EEG 'signatures', and these identification
marks have been useful to

sending you a few of our recent reprints. it is
my belief that this material lends itself to a popular presentation,
and perhaps i could, if you agree, try such a description at the time

us. Separately,
I

i

am

prepare the opiate report.
My

completion

may

thanks for your invitation, and
be within your schedule.

i

trust the date for

Sincerely yours,

i
E

Max

E

l
r

l
i

Fink,

M.D.

Professor of Psychiatry

i

r

V

October 25, l97l

i

i

.w—w

Send

letters to:

P.0. Box 269
Great Neck, New York ll022
U.S.A.

WWW-“WW plan-w:

�</text>
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                    <text>wwwv-

.

W...» _..

.07.,‘w—rn .

,

v

_”a

in.

l

,

.

,

vw-wn—wm

,

‘

a...

,

‘

.w—

"V-‘avlv...

,

111W

.—

“.mp

s...

m~wwu—-vm~_w——W

October 25, 1971
Dr. H.

M.

van Praag

University Clinic
University of Groningen
Groningen, Netherlands
Dear Dr. van Praag,

Enclosed is the report on the present status of
research into the problem of opiate dependence, from the point of
view of theories and practice of biological therapies. If the
message is too long, feel free to delete any section that may

interest

you

least,

The

report

on cannabis

and should be out by Wednesday.
on a

Again,

fine program.

my

psychosis is

now

at the typist

thanks for your invitation and congratulations

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

"Kl-"V." w-vr-w—W“. "xv—umvm awn

�</text>
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                    <text>October 28, 1971
Dr. William C. Bunney

National Institute of Mental Health
Rockville, Maryland

Dear Bif,

I very much regret not being able to fly down today. It
is
first time I was grounded commercially in years, and I found
the experience most frustrating.
the

Had I been there, I would have told of the availability of
the naloxone pamoate, which apparently has been offered by Endo to
our laboratories for study; and the tests that should be done with BC
2605 of Bristol; as well as the new findings with l—alpha acetylmethadol.
The latter study is completed and as soon as the report is retyped, I

will send
forms

you a copy.

I am returning the travel request
for your files.

and other

official

Separately, also, I am sending ypu a copy of the
revised proposal for studies in Greece of chronic cannabis users.
Needless to say, I will c00perate with your program for
other treatments of opiate dependence—- I hope more successfully than
in attending this meeting.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="106324">
                    <text>WW7

mgr

Iww"

a,

we.

r

-

n1

M-‘r-w

w-xm

r

w‘-"

.

*V

mm "

_

,

W‘mewm‘w wm}vmwﬁwpw

yam—n.”

-u——r—..-v.,r-m. - www.mywvwﬂ‘ww.

-95."..wgw

October 28, 1971
Ron. Paul Rogers, M.C.

U.S. Congress
Washington, D.C.

Ref: A&amp;C-3—1-Drugs

Dear Congressman Rogers,
You were kind to answer my letter so optimistically,
have
I
no experience in suggesting legislation, I have
tried to outline the form that seems to me, to serve the needs.
The commission idea comes from the potential power of focussing the
energies of a group of members on 3 defined problem-- not one so broad,
that the number of options are great and the funds diverted to
provide representation of all points of view. This, in my mind, is
the potential flaw with the President's view of drug abuse control—
no man is so equipped by training or experience to lead the field in

and while

prevention, detention, military problems, education, 355.

Furthermore, you will be pleased to know, that in
the
repeated admoiishment from your office and from the
response to
academic segment of our society, two important steps have been taken
in regard to the antagonists: naloxone has been invested in a
silastic implant, and is now in animal trial in New York; and naloxone
pamoate has been produced, found safe in dogs, and is soon to go into
human trial for duration and efficacy tests in our laboratory. In
addition, there is another, potentially more potent antagonist, which
is now in human toxicity trials (BC 26OS—Bristol); and the first trials
of lealpha-acetylmethadol show a three times a week schedule to be

safe,

and as

effective as high dose, daily

methadone

in addicts.

Perhaps, the commission will come at a time when it
can reap the harvest of these early plantings, but there is so much
to be done that I still feel a specific body with a specific charge
may be appropriate now.

I shall be pleased to

suggestions at your convenience.

come

to Washington to discuss these
Sincerely yours,
Max

Fink , M.D.

Professor of Psychiatry

7.

-mv

w. .1.“ -w. "we" . .

.

”H,“

�</text>
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                    <text>chober 30, l97l
Dear Turan,
The enclosed leffer senf me lo my basembnl flles, and
have pulled dupllcafe coples of every reporf durlng +he
halcyon days of MlP's collaboraflon-- and I am sendlng these
10 you separafely. I fall, however, To flnd fhe repor+ requested
ln fhe enclosed lefler, whlch ls who? sent me to my flles ln The
flrsf place. And, lhe EEG manual by Shaplro -- l have one lasf, flle
copy. Perhaps Thls Issue should be redone and republished.
l

By now you
My

besl

To

could be back. Trusf

all ls well.

Ellen.
Slncerely yours,

�</text>
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                    <text>EdiTor,

OcTober
JAMA

3i, |97i

American Medical AssociaTion

Chicago,

illinois

Sir:
i am
wriTing in reference To The reporT by The AMA Council
on MenTal HealTh, "NarcoTics and Medical PracTice" in The issue of
OcTober 25. While The reporT repeaTs The convenTionai expressions of
earlier reporTs, There are Two faceTs of The TreaTmenT of oplaTe
dependence of The meophine Type ThaT are presenTed so poorly as To
warranT commenT.

AfTer agreeing ThaT meThadone mainTenance is a logical

procedure for communiTy agencies, The CommiTTee recommends This
TreaTmenT as noT feasible for office prachce, noTing ThaT The individual
physician ". . . cannoT provide all of The services for The various
TherapeuTic needs of The paTienT." As i know of no evidence ThaT
meThadone mainTenance is therapeutic, nor of any evidence ThaT some
'TherapeuTic services' affecT The course of The disorder in subjecTs
receiving meThadone as Their primary TreaTmenT. Could iT be, ThaT The
Council is once again presenTing ex cathedra opinions based on no
evidence, To suiy some public needs or prejudices ? Would iT noT
be more honesT To suggesT ThaT The fear of illiciT disTribuTion of
meThadone puTs The AMA Council on The side of limiTed disTrlbuTion,
and if ways could be found To use physicians wiThouT seepage, ThaT
This would be as saTisfacTory as any oTher means of dlsTribuTion
ThaT provided medlcaTlon wiThouT seepage ?
A second issue is ThaT The secTion on research repeaTs The
sTaTemenTs of years pasT, wlThouT acknowledgemenT ThaT some progress
has been made in Two areas- The use of narcoTic anTagonisTs of The
specific Type (see JAMA, 202:l9l—l94, i967; ibid, 215:2l08-2ll0,i97i;
Science, 169: i005-l006, l970) and in The conTagbous Theory of opiaTe
dependence— The laTTer providing an alTernaTe Theory To The convenTionai
'bad psyche' Theory implied in The CommlTTee's recommendaTions.

There are oTher discrepancies wiTh experience which suggesT
ThaT The Council has noT Taken lTs charge seriously.

Sincerely yours,
Max

Fink,

M.D.

Professor of PsychiaTry

�</text>
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                    <text>October 31, 1971
Dr. U.

J. Jovanovic

Universitats-Hervenklinik u. Poliklinik

Fuchsleinstrasse 15

87 Wurxburg, Germany

Dear Dr. Jovanovic,
symposium,

to

New

York

Enclosed

is a copy of my presentation at the recent
of Sleep". I regret the delay but I did not return

"The Nature

until

mid October.

very much enjoyed the meeting, and wcmt to take this
I
to
opportunity
congratulate you on a fine meeting, well organised and
well run. Most interesting for me, was the occasion to meet many of your
co—workers and to realize that in a few years you have created a most
productive research group. I look forward to the results of your labors
in the scientific press with interest and optimism.
My

best regards, and

my

thanks

for your kind invitation.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

�</text>
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                    <text>July 1, 1971
Dr. Henry

Brill

Pilgrim State Hospital

Brentwood, New York
Dear Henry,

I am pleased to enclose a summary of my report of my visit
to the University of the West Indies, and my letter to Dr. Beaubrun,
suggesting a collaborative study in the winter of 1972.
Should he concur in the recommendations, I should like to
the Marijuana Commission for support, particularly if
may be useful to do the study promptly.

call

it

on

I told Dr. Beeubrun of your interest in cannabis research,
and your central role in our study in Athens. and he expressed
an interest in meeting you in Jamaica this winter.
my

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Pnychiatry

�</text>
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                    <text>July 1, 1971
General Plinting Office
Washington, D.C.
Gontlcncn:
Kindly send us 100 copies of
GPO-1034A
We

hold contract

Public Voucher for Purchases
and Services Other than Personnel.

HSM~42—70—98.

Thank you.

Sincerely yours,
Fink, M.D.
Executive Director

Max

Mszt

�</text>
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                    <text>mar—VW'WRIW“

July 2,
Dr. Jerome

3-}.

1971

Jaffe

Special Counsultent
to the President

The White House

Hashington, B.C.
Dear

will

Jerry,
The grapevine has you

be

off for

Viet~Nam, an&amp; I

trust

your

trip

helpful in clarifying the facts of drug abuse along our

servicemen and

their dependents.

called earlier this

week, and I freely shared our data
£150 sent him a copy of the program of the looting on
narcotic antagonists to be held in Aberdeen, July 12-13, and a copy
of a small project to get studies of M-soso off the ground.
Roger

with him.

1

It is apparent that neither

NIHH, BEBE, ”AS/NRC,

nor industry

have provided the leadership to develop the antagonists. I believe
the appointment of either I committee or an ”office* for this
dovelopment would be a necessary first step. New York City mas
established such a committee but included no one with dedication

or interest and
A.

it is

ineffectual.

In answer to your questions, the projects that are important
(1) Testing cyclazocine prophylaxis in Viet-Ncm, using

available oral doses of

2~4

ng/day,

coubined with.naloxonc during the
(2)

a

rapid induction schedule,

first

Develop u long acting

week.

antagonist.

(a) Contracts for trials with naloxone, using
such methods as depotaoil, silastic, plastic film;

this

(b)

Change import quotas fOr

(c)

Trials for

thebeine and import

other raw materials for naloxone; and, establish
supply of naloxone for clinical research.
and

u long

an adequate

acting cyclazocine.

�—~e:an‘-m-MWWW

Jaffe

Dr.

-2-

July 2,

1971

unn-

"
‘vvf

iv

Test and establish the pharmacology, clinical toxicology

(3)

~—

clinical trials with

and

useful, introduce

it

M—SOSO

and

into trials of

EN

If either

1639A.

compound

a long acting formulation.

is

(4) Clinical trials of cyclarocine or naloxone in direct
comparison with methadone or l—alpha~acetylmethadol.
B.

The

"guesstimate" costs for the projects,

on a

"crash" basis:

(I) frophyl§§i§_- for consulting expenses US-VietNam, 4—6
$10,000; local military costs; supplies to be defined
staff
by Sterling~Winthr0p based on size of study.
members

(2)

—

Long

acting development

(lst year).

$800,000 (4 contracts

Naloxone

Thebaine and naloxone supplies $250,000
Cyclazocine

status of

(3)

M—5050

Pharmacology

1639A,

but for

M-SOSO:

and

EN

Animal pharmacology

Clinical trials
Supplies

.m—

:

6

VA

(4)

clinics,

Clinical

600

added to present
C.

Role

If

1639.

I do

?

not

9

$200,000)

know

the

$42,000
120,000

50,000

Comparison Cyclazocine-Methadone:
$200,000 organization cost

patients, additional

VA

allocations of $400,000/unit.

for myself.
you

establish

a commission, I suggest you consider
F. Blane or K. W. Bentley
I would be pleased to be

J. Villareal, D. Jasinski, G.
(Great Britain), J. Woods and A. Kurland.

A.

Freedman,

a member or to chair

it.

I have been actively soliciting the cooperation from industry
a few years and now know many of the people who could be involved
in a long acting drug research program. If a committee were set up
and given the support its studies justified, the programs would be
successful in a reasonable time. They may require some special
regulations regarding financial rights to industry, however, and some
cooperation from BNDD.

for

,

�&lt;_:-v..-

"1"”

.

Dr.

Jaffe

-1-

July 2,

1971

Should you wish to undertake this program yourself, or have
Roger, John or someone else do it, I will make my files available
and introduce your appointee to the appropriate persons.

Incidentally, Villareal and Kosterlitz are chairing a symposium
the antagonists in Aberdeen, July 12~13 and you may wish to attend
or send someone. I sent Roger a copy of the program in case you had
not seen it.
on

Again,

my

best wishes for the rapid success of your mission.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>July 6, 1971
Dr. Gilbert Kayne
Merck, Sharp 8 Dohme
wast Point, Paunsylvania 19486
Dear

Gil,

Enclosed are two articles from the book “Narcotic Drugs
Biochemical Pharmacology”, edited by Dorothy Clone: and publiahed
by Plenum.

Have a

nice

summer!

Sincctgly yours,
Max

Fink, “.0.

Professor of Psychiatry

�</text>
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