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                    <text>-r

«war—Wm :u,

—..

v.—-‘—vm-um‘,pv_..m -:‘n‘.w m

.

Hmwrwm"~me w-mms—v-W

February 8, 1972
Max

Gordon, Ph.D.

Bristol Laboratories
Syracuse,

New

York

Dear Max,

a follow-up on the inquiry on Clumacran, I asked
the
to review the notas in their files, and I received the
enclosed extensive print~out. This may be 01 interest.
As

ﬂIMH-PRB

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

w—uvv—mn

»

v

m

�</text>
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                    <text>February 8, 1972

Prof.

Hebrew

Israel

R. Mechoulam

University of Jerusalem

Dear Prof. Mechoulam,

&lt;7

:-

Mammy-”WV

I have just returned from examining some of the chronic
hashish users in the laboratory of Prof. Miras in Athens. We observed
4 men as they smoked various doses of hashish, U.S. grown marijuana,
THC impregnated placebo marijuana, and placebo marijuana. Our data
is confusing, for the men exhibited 'tolerance' to hashish, but not
to marijuana; they showed behavioral changes to marijuana which seemed
distinguishable from their responses to hashish; and they showed
no reaponse to 75 mg THC.
One

&lt;v:

is the different

of the

mix of

possibilities underlying these
constituents in the

mixed observations

two samples. Before

leaving

Athens, Prof. Miras provided us with another sample of hashish which
has a low concentration of THC, and the men reported this sample to be

'without

effect'.

are replicating these observations in another sample;
THC~A~9 and ~8. I have some
samples of the two types of hashish, and the U.S. marijuana, and I am
writing to ask if you would be willing to assay these for us. There
is some question in our minds as to the actual concentration of the
presumed active substances. May I send 4-6 samples to you ?
and

We

will undertake additional trials with

Many

thanks.

O

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
“swap-7m

vvm-J

rummrvrr‘r'

~
"“7

=

-.

W‘V'm'li‘

mam.

“Mvm‘cvir

�</text>
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                    <text>February 11, 1972

Dr. Robert Petersen

Division of Narcotic Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Bob:

Enclosed are the two revised budgets, for the Jamaica

and Greek study prOgrams.

Separately we will send the detailed progress report and
protocol for the Greek study, probably within the next 10-15 days.
For the Jamaica study, we are unable to relate our proposal
to the prior study without your help. With it, we will accommodate
the social aspects to the data of the prior study.
Many

thanks for yourttime.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming
Bic.

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                    <text>n‘w‘

Va.

r-

-

vm

uw

4v

m

«wu—

--

.

~

W “fl-WW"

1-:

v.

,

rdm'wv'nvv"mwl'melwvva—H."IMF—VJ «.wi van

:-

Fabruary 22, 1972

Binaa, Ph.D.
Director of Biological Research
Hoffmann—La Roche, Inc.
Nutley, ﬂew Jersey 07110
Mr. L. R.

Dear Len:

I hava read the data ahaata on Lorfan and RD 6-6711 with
interest. ﬁocuaaing on thair possible uaa in opiate dapandanca.
The data on Ro 4~67ll ahows this to be similar to cyclazocine in structure, with similar side—effects on low oral dosage
(0.5 mg) - sleepy, uncomfortable thoughts, “drunk",bhtt with
vomiting also. Thasa effects reflect a nigh dagraa of agoniatic
effects, canaidarably reducing our intaraat.
data on Lorfan is more promising. It is a well defined
antagonist, and a program dcaignad to extand its duration of action
may be useful. It may be important, howavar, to clarify the commant
in the packaga insert, regarding enhanced respiratory dapraasion
with repeated doaaa. If varifiad, this will be a deterrant to further davolopaant.
The

Thanka

for the opportunity to raviaw these data.
Sincerely yours,
Fink, ﬁ.D.
Professor of Psychiatry
Max

�</text>
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                    <text>February 22, 1972
Dear Dr. Plstcow,

It is quite

I have read the section

good, and

my

on

few comments are

antidepressants carefully.

listed in the margins.

I would suggest that the sections related to the presumed
effectiveness of the MAUI be reviewed, for the available data is chiefly
uncontrolled testimonials. The list of dangers is well documented, however,
and the contrast sufficiently great for us to have eschewed the use of these
drugs in our treatment programs. Indeed, the risks are as great as with the
amphetamines, and perhaps the same cautionary tones should be encouraged.

Recent evaluations of convulsive therapy, particularly
with the modification of unilateral ECT, with succinylcholine and
Brevitsl, show this technique to be 80~9OZ effective (and safe) in severe
depressive states. Perhaps the Council should review the whole range of
therapies listed under 'antidepresssnts', and introduce a section on ECT.
This treatment is surely more effective and safer than the amphetamines
or MAUI. For a recent comprehensive review, see the February issue of
'Saﬁfﬁafg {M organtatﬁy; published by Grune &amp; Strstton.

these notes

may

Finally,

may

give in the

I ask that

list

you acknowledge the

of acknowledgements

? Many

little

thanks.

help

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Mex

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                    <text>February 22, 1972

M133

Roberta London

Monoging Editor
Contemporary Drug Problems
515 Oxford Street
Heatbury, ﬂew York 11590
Dear H139 London:

v'-

made, the biography submitted, and the
I nave added the latest data to the text, and the
title shortened.
N133 and the White ﬁance
report should be most timely, for the USPHSon- the
antagonists, which
SAODAP are both preparing larger programs
should be announced shortly.
The

own—mop."

“h...

.w

awn..-”

—

v

~—~w-w

corrections are

additional chores, should you docide to prepare a cannabis issue, our studies of the acute and chronic
effects, both in New York and in Athens, are most interesting.
While I am not looking for

I look torwcrd to seeing your

anwwuuy—mv—

first issue.

Good

luck!

Sincerely yours,

,

A

—».

an: Fink, M.D.
Protector of Psychiatry

-~v~mr——wmm.._

Ming
Enc.

.
W.—

A

.mmm

»

"'

mm.

-

w”-

'w-pm

-

�Dr. Max Fink is Professor of Psychiatry and Director of the
Division of Biological Paychiatry of the New York Medical College
in New York City. Since 1966, on has extensively studied the neuro—
physiologic and clinical effecte of narcotic substitutea and antagonieta in opiate dependence. and the effects of chronic cannabis use,
both in the United States and overseas.
He is a graduate of the Rev York University College of Mad~
icine (1945); is certified in neurology (1952) and paychiatry (1954)

the American Boards of Psychiatry and Neurology; and in paycheanalyaia (1953) by the William Alanaon White Institute (New York).
In a research career begun in 1954. he has been Director of Raaearch
at Hillside Hospital (New York) (195A-l962), and Director of the
Missouri Institute of Psychiatry, and Raeearch Professor at Washington University (St. Louis) (1962-1966).
by

Hie principal studies are in the neurOphysiologic (electro—
encephalographic) and clinical effects of psychoactive drugs and
coneeileie therapy. Applying computer methods to these analyaea.
he has provided theoretic models of the relation of EEG changes and
behavior in man, and of the node of action of convulsive therapy.
He

has

just edited a special issue of

Seminanb

in Pbychiazay devoted

to convulsive therapy, and will chair an international symposium on
this subject in collaboration with the Rational Institute of Mental

Healtu in 1972.

Institute of Mental
Administration, the Columbia Broadcasting
Syetem, and numerous industrial concerns. He is the Executive Di—
rector of the International Association for Psychiatric Research,
Inc. He is married, father of three, and is a resident of Great Neck.
He

Health, the
Long

has been a consultant to the National

Island.

Food and ﬂrug

�</text>
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                    <text>,

WWW”.

.-_‘-.,.___v.-.

.mm

.mm,..,-_,..

.,.,,,_WI

,.

February 22, 1972
Samuel C. Kain, M.D.

Director, Alcohol

&amp;

Drug Dependence Service

Veterans Administration
Washington, D.C. 20420
Dear Sam,

.m

pawl-"Wu”...‘mu,’

I look forward to participating in the 17th annual V.A.
Conference in St. Louis next month. At the and of the week, I will have the
time to write a summary of my presentation on tho panel, and should send
it to you next nook, well in time for the session.
A.nhort c.v. is enclosed.
For the teaching session, I will prepare a summary of our
present treatmont approaches, onphacizing the similarities and the
differenceosin using mnthadono and lnvoncthadyl, and cyclazocino and n31—
crane; and the relation of thosn drug rcgimona to rohabilitation, caaawork,
re»education, counselling, and psychopherapy.

It was kind of you to consider my serving on the steering
committee for the collnborative studios in drug abuse, particularly for
acetylmcthadol. I would be pleased to contribute whatever I can. and have
that my experience may be of assistance. (My paper on l~alpha~acotylmethado1
will appear soon in the J.A.M.A.~— they changed the name of the drug to
the

new

generic

'official' titlo of

My

LEVUNETHADIL.)

best regards.
Sincerely yours,
Max

Fink, 3.9.

Professor of Psychiatry

�</text>
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                    <text>February 22, 1972
Dr. E. Garden

Boston State Hospital
Boston, Maaaachusetts
Dear Dr. Gardos,

Enclosed is thc summary report 0! the EEG data analyses
of the high and low dose thlothixcnc studies completed recently. while there

technical difficulties, there was sufficient material to elicit
drug~EEG effects in the lang~tcrm treatment condition. Thu ahort~tcrm
cffccta were less clear, probably as a result of the small sample.
The decrease in mean frequency and in mean frequency
is consistent
variability measures with chronic thiothixcne administration
the
and
with
of
thiothlxcne,
thc
effects
of
ctudica
with our earlier
Pharmacol.
CAnn.
Rev.
earlier
publications
classification proposed in our

were some

9:2blv258, 1969).

h

I trust these data are
information, please call.
Hy

artful.

Should you wish any

further

best regards.
Sincerely yours,
Max

Fink, M.D.

Profcsaor of Psychiatry

cc:

J. 0.

Cole

�</text>
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                    <text>February 22, 1972
Norman

Pitts,

M.D.

Pfizer Pharmaceuticals
Groton, Connecticut
Dear Norman,

time ago, Garden and Cole asked us to

Some

assist

them

in the analysis of their date of a chronic high and low dose thiothixene
study. They supplied the tapes, we did the analyses. There were some
problems in the data collection, related chiefly to the copperation
of the patients and our inability to train the staff adequately. Hevcrtheleaa,
the analyses do demonstrate consistent EEG effects, similar for the high
dose thiothixene as
summary

I

we

am

found some time ago.

taking the Opportunity to send you a copy of the

report, for your information.
My best regards.

Sincerely yours,
Fink, M;D.
Professor of Psychiatry

Max

�</text>
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    <fileContainer>
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                  <elementText elementTextId="106385">
                    <text>~“K‘

“-‘mw‘vﬂrw-‘m'"' mm run: n“

"Km 7

‘

»-

'_—zvs.uv§"""xJorv-«mtl‘H-m-rq rm. haw-v! 7‘

«awn

-

1:.er

wry-w

x:-— v—lwa-rh

«no-.W‘ -‘ur',—).In ”p"...

,

\

,_, Ht... “Hrs," w”,

_

.

.

1...

__,.,‘V

.Y,

‘_

March 33, 1972

Julian It. Laoky,
ﬁational Institute of'obntal Boalth
PEAK}.

ﬂockville,

234m land

Eef: mom

M23158~01

Dear Jack,

While the propocal, "Treatment of'Schiaophrenia by
important and interesting goals, the methods are

EU?" has

Regressive
inadequate to

it

tile?

wish. to encourage such
tho invoctigatom to discuss

task. Shoula tho Comrlttoo

for
a program,
'tao loouoo with others: tho lntorrolationo of’modiflcations of‘tﬁe
EC? process to thorapoutlc outcome, and the ioauos in quantifloatlon
of the EEG. In addition, since the twin leouoo in rogrosoivo 3326‘? from
a publéo health point of'olow are the long torn offocto of‘multlple
ooizuroe, coon as an assault on the oontral nervous syctong particularly
on matures of brain function and on ouch capacities as concorztmt’lon,
momory, and thought processes, the evaluation of‘nourological doflcéts
and paychologicol tosto fbouoaod ow what to usually called 'organiolty’
must be conoldored.
would be adviecdalo

The investigators have done an
of'rcgrocoioe EC? in schizophrenic patients.

interesting clinical study
There to a mood for such

a ro~ovaluatlon of’rogroaaivo ﬁll; for thin modification has a chequered
rarely useful. Recent otudloa of’multlple
history. Oldor studies found
Elf; undor omygonatlon control, have indicatod that multiple ECT ans

it

dofloito, or EEG
soft, producing no moro momory loss, neurological ECT
only occasionally
changes than single ECT. Unfortunately, multiple
produces bettor results than single EST in doproeood patients. The data
for schizophrenic patients is unclear, holevor; and thorn now are some
roports of'bottar results with multiple ECT. Those data require vorifloation, and in this framowork, the proposal by Ewnar warrants some

aselstanoo.1h its prooont form, it is inodbquate to the tasks outlined
by the investigators, and suggested by my view of the public health ioauoa.
5%:

favorable foaturos of the proposal:

1) the population is adequate, and the setting to probably a good one for
such studies. (1h our investigations of ECT at Gracia Square and Hillside,
was in those small hospitals that tho staff’wore favorably diaposod tp

it

Elf; allowing tho inventigationa to proceed.)
2)

Tﬁo

investigatora

have an

interact and

coma

experience in regressive

ECT.

�.-&lt;

. .w-r—

"J‘znmp

‘wr w-n-nru-vg-m7r34W.v'ur.vu_I-4—-'m5"|0rat-,JTW
”g:-

"mrﬂR'w-ﬂ -r--vn-:VI' \‘N'I~’&gt;A'Wlmm’w

W\Jr‘v4r-'wv-n.wl Jaw.

EXNERO'IIOOOOOUOIOOOOOIOIOOOOOOI. EICOIOOIOOOOOODO

3) The PI

..

.

.n,

.

‘n'mgrﬂwrr

:IWBst"-v~l*’!‘-vm

March 23’ 1972

sahibits statistical and design sophistication, and his

rocord as psychometrist

../.,._~

~....-_».-r.~n.

is

good.

"7”,

The

negative features of the proposal:

1) The design is EDT vs. drug treatment. Ihie
the design to be followed,
issue, but were

it

is not the

most important

there are specific problems.

While the evaluation methods may be adequate indices of
2)
change in personality and behavior, the issue in gegressive ECT is the
impact on interpersonal behavior, neurological deficits, thought
processes, memory, and concentration. In their first study, they
emphasise a persistence of’some of the thought disorder—- but is
and how is
changed ? The clinical aspects seem inadsquately
it different
covered, and the emphasis on a psychiatric interview no less than 30
minutes and no more than 45 minutes is mechanistic and less than helpful.

it

,

ihe EEG evaluation is at thewwrong time for any important
issue. Perhaps the EEG should be evaluated soriatim (weekly) to assess
the rate and degree of change in brain function. But most critical
is the likelihood that the patients will all receive drugs after the
treatment course. The druggcontrols of‘neeeseity; the EC? patients
most probably. Since no statement is Mada about the specific drugs,
dosages, and relation of.EEG measures to drug intake, I have to assume
the investigators are not acutely aware of the impact of drugs on the
536. To unravel EEG effects of BCT from drugs without attention to
the controls necessary, is exceedingly dijyicult.
Zhe same problem in the evaluation and followvup will
occur for other indicss»~ what is the impact of'drugs given after
regressive EC? on the EC? process, and on the comparison of ECT and
drugs ? (For this reason, I would favor regressive ECT vs single ECT).

3)
Patient selection is an issue. The statement of'proceee
schizophrenia is inadequate. The tests described are too non~specific
to help others define the population. It were better for the investigators
to specify which criteria of'process schizophrenia they use (3.9. Fish,
ﬂuylor, others ?). Psychological tests are supplementary~~ they cannot
be used as the diagnostic criteria.

criteria

While

I

am

not ordinarity prone to question selection

ethical grounds, in this instance, the authors should be
asked to make clear some of their minimum criteria of'prior treatmonts
and failure, recent treatmont and failure, etc. before regressive ECT.
Should not all patients have had a course of 'regular' ECT and failed ?
4)
Psychological tests are given heavy emphasis, but the
theoretic base from which these tests more selected is not indicated.
Why the MMPI and the SPEC ? Neither is sufficiently specific in its
interpretation to be very helpful.
on

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23’ 1972

There are many problems with the EEG measures, but since
I)
the study could be done without EEG measures, I will not go into full
detail of’theinadequacies. It is not clear why the investigators are
measuring EEG effects, for the only specific suggestion comes from the
description of lack of’abnormality before and after treatment, as

evaluated by the neurologists on visual inspection. Ihe issues
that could be investigated are the differences in EEG effects of
regressive ECT vs other Elﬂk the rate at which the induced changes
disappear; the relation of change to improvement, to memory ef?ects,
or to other neurological indicee.

They suggest quantification of'the EEG; suggesting
recording and analysis for short epochs. The equipment they
request, representing a large part of'the budget, is adequate only for
the analog to digital convereion, and some simple steps of'data reduction.
But EEG data ie voluminous, even when reduced, and the interrelations
among many channels a horrendous task. (Indeed, very few investigators
have challenged more than one or 2 channel data, and if'more, only for
1 0r 2 minute epoche).
3 channel

To

is

Their interest in sleep

EEG

is unjustified in the protocol.

eben suggest cloep EEG recording (3 hours), for 8 channels (1),
so voluminous a tack, tiat I suspect they do not mean this. gheir

suggestion about.doing visual analysis of the sleep records is
interesting, but thie too it a big tack, and will not in their
few cases, answer any of the auctions. She came problem of drug
control must be considered here.
#-

10

d

J!

.Ez.reureading this proposal, I believe the investigator
brings to the questions, posed by his clinical colleagues, and experience
as a clinical psychologist and psychometrician. fhese aspects seem well
handled. For 'eeientific' reasons and interests, they are suggesting
EEG analyses, sleep recording, and some follow~up studies. In these
aspects, they seem to lack experience, but also sufficient judgment to
visualize the taske and to obtain advice. Perhaps, were they encouraged
to visit and'worh ith one of the university based centers studying
ECT and one focussed on quantification of the EEG, these issues might
become clearer to them. were they then still interested in the studies
suggested here, a better proposal might (?) be forthcoming.

Alternatively, the design could be reduced to a clinical
replication of their pilot study, with some better statement of'the
population, assessment of’neurologioal effects, control of EC? parameters
and drugs, etc.—- and a contribution made to the EC? literature. In the
latter case, the budget could be subjected to reworking, deleting
sleep and statistical consultants ($3800), equipment ($20,500), and
EEG chart paper ($600); with additions for neurological evaluation.
helpful. Iou already know the
I trust those comments are
these
laboratories
in
interested
issues, and I am confident
principal
that any would be interested in this study.
’ISincerely yours,
Mam

Fink, M.D.

.

u--- .

.7

.,.r

,.

.

_.

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                    <text>Februnry 28, 1972

Stanley Einstein, Ph.D.
Executive Director
Institute for the Study of

680 West End Avenue
Raw York, New York 10025

Drug

Addiction
’

Bear Stan:

Th: potential importance of the narcotic antagonists in
both the trcatmant and prophylaxis of opiate use should mako a pra~
scntttion of the availablc data a muttcr of high priority. While
I do not believn the College will bu able to find the travel coat.
for the misting, I could suggest you list my presentation and be~
tween us, we should be abla to find some solution. If not. the were
listing will, at lcast, give the possibilities some visibility. and
enhance the historical record of the meeting.
As a title: "Antagonists in the Prophylaxis and Treatnnnt
of Opiate Dopandenco".

Goodlluck.

Sinceroly yours,
ﬂax Fink, H.D.
Professor of Psychiatry

HF:ig

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                    <text>February 28, 1972

Dr. Allan P. Berger:
Associate Director

Pfiur Inc.

Eastern Point Road
Grown, Connecticut 06340
RE:

Lithane

ERR 2/13/72

Dear Alan:

are most grateful for the supplica of Lithane (lithium
carbonate) which you so kindly made available to us in 1970. Silica
that time we have trested more than 20 patients, neatly those unifaring from mania, and the supplies are exhausted.
Re

Early in 1971, Lithane was approved by the fomulary courmlttee of ﬁetmpolitm Knapital Medical Center for psychiatric uses,
and is no longer "investigationnl" and not under out control.
Thank you

for your assistance.

ﬂy

best regards.

Sincerely yours ,
Fink, Md).
Professor of Psychiatry
has:

�</text>
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                    <text>WEE

‘

mum—w

March 1, 1972

Dr. Arthur W. Increiter
March Sharp 6 Donna Rascarch LaboratorieWest Point, Pennsylvania 19486
Dear Dr.

Iacroltcr:

The supply of levomethadyl arrived safely w many thanks.
augment our studies by incraaaing the
nunbcr of subjects and the time. Our report is now in galley
for the JANA, and should Appear shortly.

We

will use this supply to
My

best regards.
Sincerely yours,
2h! Fink, Moi):
Professor of Psychiatry

mrzig

cc; Clyda Strickland, 3.0.

�</text>
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                    <text>March 6, 1972

Dr. Joe P. Tupﬁno

Professor
Enivoroity of California
Division of Mental Health
Dopartmont of Psychiatry
bovis, California 95616
Bear Joe:

In thinking about your wish for a young psychiatrist, thorn
staff, Jan Volavka, and Richard Abrams who have
good backgrounds and are interested in leaving New York for annular
cllmes. Their curriculum vitaeo are attachod.
are

two men on my

Volavka is a fine eloctroencephalographer, good statisticion,
and a methodical and industrious worker. Be is new to the grants
systeaa, and has been sponsored by me. so has no active grant. pro~

grams. a. is the principal scientist in my heroin study 33—19476.
ﬁlo publication list is extensive. and his work is of high quality.
so that I on confident he will be able to establish a program.
Abramo

my SGT

is younger.

study program.

Mﬂ~15561. and

evaluations.

He

t

clinician

who aas worked

is the printlpnl worker of

in charge of the

payohoPharmacology

I on willing to "roloasu” those

hero but aro Instive because of
Good

How

men

actively

my BC?

clinic's

luck.
Sincerely yours,
Fink, H.D.

Proton-or o! Psychlttry

ﬁrst;
too.

grant

new

drug

since they haw! grown

York's many haxolea.

3::

on

�</text>
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                    <text>hwy—raw

,

W;vw—.m-r....,—.

-~—-.

”ﬁrm

.

m

m

March 6, 1972

Mrs. Elaine Gasasso

Executive Secretary

American Society for Clinical
Pharmacology 6 Therapeutics
Houston Oaks Hotel
Houston, Texas
Dear Mrs. Galasso:

Please extend my regrets to Chris
for I will
be unable to addend the Scientific Awards Zarafonetis,
Committee meeting on
March 8, in Houston.
Thank you.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
MF:1g

�</text>
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                    <text>February 8, 1972

Miss Risa Dickstein
Vera Institute of Justice

30 East 39th Street
New York, New York

Dear Risa:

I read of your presentation to a legistative commission
on Friday, and realized that the heroin program has been well
formulated. If a copy of the proposal is freely available, my
associates and I would like to read it.
Good

luck, and

many

thanks.
Sincerely yours,
i‘lax

Fink ,

1‘1

0

D

0

Professor of Psychiatry
Ming

�</text>
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                    <text>February 11, 1972

Dr. Robert Petersen
Division of Narcotic Drug Abuse
National Institute of Mental Health
5600 Fishers Lane

hockvi lle , .i'aryl and

20 852

near Bob:
Enclosed are the two revised budgets, for the Jamaica

and Greek study programs.

Separately we will send the detailed progress report and
protocol for the Greek study, probably within the next 10~15 days.
For the Jamaica study, we are unable to relate our proposal
we will accommodate
to the prior study without your help. With

it,

the social aSpects to the data of the prior study.
Many

thanks for yourttime.

Sincerely yours,
MEX

Fink ,

2‘. D a

Professor of Psychiatry

HF:ig
Eﬂc.

�</text>
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                    <text>P-

we?

March 10, 1972

De. Daniel X. Freedman

Professor and Chairman
The University of Chicago
Department of Psychiatry
950 East 59th

Chicago,

Street

Illinois

60637

Dear Dan:

It was a pleasure to discuss the opiate antagonists as a model
for the treatment and prevention of Opiate abuse, and it may be useful
to outline some issues of interest.
Neither cyclazocine nor naloxone, as now formulated, are prac—
of opiate dependence. At best, we have
been able to sustain a select group of Opiate users with cyclazocine
for up to 5 years, and some are now drug free __ but the number is small,
and I believe our success to be as much a result of the dedication of
my staff as to any specific pharmacologic activity.
But these experi~
ments demonstrate that the antagonists provide effective narcotic blockade; that they are safe; and that tissue tolerance does not develop to
the antagonistic actions. They also indicate that drug delivery ~~ a
sustained delivery of weeks or months -- is the immediate hurdle to
overcome. As the bnger duration of action of methadone and levomethadyl
make maintenance therapy feasible, so too, a prolonged
acting antagonist
would make both deconditioning and phophylaxis clinically realistic.

tical in the clinical treatment

From this point of View, there are thcee practical problems:
the development of a long-acting delivery system; identification of
more potent additional 'pure' antagonists, of greater duration of action; and, biochemical synthesis methods to assure an adequate supply
of medication.

,crn

�Dr. Daniel X. Freeman

March 10, 1972

-

1) Long-action. There are many routes that can be examined
substitution of a long~chain fatty acid to delay absorption and degradatiOn (similar to fluphenazine enanthate and naloxone pamoate); modified crystallizations (as utilized by Janssen for a long acting antipsychotic drug); investment in a biodegradeable silastic (as suggested
by the Population Council for anti—ovulatory agents); or other novel
altered delivery systems as developed by some ingenious chemists for

ophthalmic drugs.
We

have supported one study of silastic and defined the charmethod using naloxone as the base. The study was

acteristics of this

discontinued for lack of funds. It warrants continued support, despite
the long term nature and potential expense of the investment.
We

have also completed

observing that

6

initial

human

assays of naloxone pamoate,

cc intramuscular prolongs the duration of antagonism

diacetylmorphine/chlZ minutes (a 'heroin challenge') to 60
an increase in duration of at least 15 times. This salutary
demonstrates
the feasibility of the approach.
step

to 25
hours

mg
—~

A long~acting 'pure' antagonist. 0f the tested drugs, nal—
the
'cleanest' compound, hut it has many disadvantages a" its
is
duration of action is 2—4 hours; it is ineffective on oral administra—
tion (we required 3.0 grams to extend duration to 24 hours); and it is
expensive and difficult to manufacture, limiting its supply. Other
compounds warrant testing, and of these M 5050 has the most promise,
based on animal trials. To test this compound, it is necessary to first
complete adequate animal toxicology. (This step has precluded human

2)

oxone

assay for more than 2 years, for no agency which we approached was will—
ing to provide the funds. Happily, funds were approved on March 3 for

these

trials).

In addition to this compound, there are

many others that war~
have been examined by the University of
Michigan for antagonist potency, and these data are 'hidden' in the
archives of the NRC/NAB. At the request of various agencies, Dr. Vil~
lareal nas agreed (February, 1972) to undertake a review of the data;
and should other compounds be identified, these should be assayed in
man, with particular emphasis on their 'purity', degree of antagonism,
and duration.

rant study.

Many compounds

'

Under the

have returned to
compounds. This

Sterling

stimulation of Congress, various industrial concerns
their laboratories and examined their files for active
is true for Merck (levellorphan), Bristol (BC 2605),

Winthrop (ﬁ-cyclazocine), and Geigy (GPA 2163)

drugs warrant more intensive examinations.

--

and these

�March 10, 1972

Dr. Daniel X. Freedman

Finally, perhaps an interested scientistwith experience in
analgesics, could be encouraged to visit various laboratories to dis—
cuss on an individual basis, the availability of compounds or congeners
in their files. When this was recently done with Janssen in Belgium,
we were able to identify two possible compounds of interest, and to
stimulate their further study.
3) Biochemttal synthesis methods. The basic chemicals from
which these antagonists are derived are in short supply, apparently
because their manufacture is derived from thebaine, a proscribed commodity. Some effort should be made for chemists and botanists to iden—
tify other manufacturing methods and other sources of the raw materials.

In this review, I have neglected the need for training psychi-

atrists and clinical pharmacologists in the special problems of studies
in addicted persons (patients usually have a different agenda than the
scientist); the need for studies of the extinction of learned patterns;

and the need for the studies of the dependence process itself. These
general issues are of special concern to the committees of the National
Institute of Hental Health, and will surely occupy the attention of
the new proposed centers.

In our discussions of the

ways

in which these studies could

attract the attention of scientists in universities and industry, one
suggestion may be of Special interest. Should an agency, preferably

non~governmental, outline the needs for a long acting antagonist, de—
fine a reasonable deadline, and offer a prize of significance, would
this not stimulate those men who may be unable to visualize the needs
of the formulation, to attempt its development? Should an agency offer
$50,000 or $100,000 for the development of a narcotic antagonist, with
a duration of a single administration of 60 days, sufficient to block~
ade diacetylmorpnine 25 mg/2 cc/2 minutes, in man «s would this not
stimulate some interest? (An example is the announcement of the Anna
ﬁonika Foundation prize).
Two additional needs: support for academic scientists to work
directly with industry on a 3»6 month 'fellowship' basis; and support
for regular meetings of investigators interested in the narcotic antago
onists, similar to the annual methadone meetings. (When we suggested

the methadone meetings set aside time for the antagonist workers in
York and in San Francisco, our suggestion was denied. The only
special meeting was sponsored by NINE and the New York Medical College
on June 4, 1970).

Nan

�{I

Dr. Daniel X. Freedman

March 10, 1972

These are some random notes. Should you be interested in the'
will provide what I have. Meanwhile, my latest summary
as prepared for Contemponaty Dnug Pnobﬁeme is enclosed.

'back—up', I

Again,

my

thanks for lending ye your ears.

My

best regards.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
HF:ig
Eﬂnc;

�</text>
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Match 11, 1972

Stanley Yollen, M.D.
Professor &amp; Chairman
Department of Psychiatry
SUR23§tony Brook

Stony Brook,

New

York

Dear Stan,

It gives me great pleasure to recommend the appointment
of Khan Dotnbush, Ph.D. to the Department. I have known her for almost
four years, and during this time she has made extensive and valuable
contributions to my studies of ECT and cannabis. She is particularly
involved with cannabis research at the present time.
She has chm

record and the experience to be considered

for the academic rank of Antaciate Profeencr.

Initially, funds for her appointment will be available
anticipated grants, particularly the transfer of ME 13358,
my EEG study program. I would anticipate, that should her
appointment be approved, that she will establsih her own study pro~
gram in cannabis research, and I would be pleased to assist her
applications.

from the
which is

In addition to her appointmant to the Department of
Psychiatry, I believe she could make a valuabla contribution to the
work of the Department of Psychology, and would suggest that she be
considered for a concurrent appointment in that Department.
Many

.—

:‘r

thanks.
Sincerely yours,

.,mt'.t‘,aor-Man,.-,u"-r

r
«

tn,

-—.m-

Fink, M.D.
Professor of Psychiatry

Max
...

mf/

�</text>
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                    <text>March 15. 1972

Dr. Monique Brenda

Division Narcotics and Drug Abuse
National Institute of Mantal Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Monique:

I an enclosing
our ongoing studies.

two 3RD forms 222—C

(or drugs needed in

are requesting 5 grams of recrystallized heroin to
continue our heroin challenges in studying the duration of action
We

of specific narcotic antagonists.
I

also requesting crystal (dry) cannabidiol, cannabinol,
We are examining the urine: of the volunteer:
of tne cannabis study and the cooperating chemist, Dr. Walter
Essnan, needs these pure substances as standards for analyses.

A—THC,

and

am

A«9—THC.

Thank you

for your cooperation.
Sincaraly yours,
Max

Fink, M.D.

Professor of Psychiatry
HF:ia
Enc.

‘cc: Dr.

R.

Peterson

�</text>
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                    <text>MEHORAHDUE

march 15, 19 72

TO:

Mrs. Ebert

F3024:

Dr.

SUBJECT :

Painting

Max

--

mint-none.

Fink

'\

We

paintadhgi
appreciate having room 42A and
\
tow
days
beginning
be
for
a
free
laboratories will
Lab 62A

would

\15‘.

The

butch 28, to ﬁnch 31.
He

would

like it to be painted a lightlz tinted blue.

Charge 89-21043 .

‘t

\\ \
».\

�</text>
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                    <text>’Jv

««U5

March 16, 1972

Dr. A. V. Bacueta

Aaaiatant Protaaaor of Neurology
and Physiology
Duh: Univnraity Medical Center
Durham, North Carolina 27710

Dear Dr. Eacuata:
Thank you for the kind invitation to chair a workshop
on ”EEG of Drugs of Abuse" at the October meeting of the American

EEG

Society in Houston. I have invited the following participants:
Everett Ellinwood,

Turan

Itil,

Jan Volavka,

H.D.

M.D.

M.D.

ﬂax Fink, M.D.

it will

Anphetaninaa

Benrodiaaepinea,
Barbituates
Opiates, Cannabis
LSD; Summary

while this will not "cover“ the variety of drugs of abuae,
highlight none of the conunnalitiee and the effects of

tolerance development.

It is our intention to summarize the EEG effects of acute
administration, differencea (if any) on chronic administration;
dosage relations; and antagonists(if any). The phenonnnon of
tolerance and cross-tolerance will be described.
It will
'

need a 2" x 2"

slide projector.

I look forward to seeing you in October.
Sincerely yonra,
Fink, M.D.
Professor of Psychiatry
Max

Mfzig

cc: E. Ellinvood, T-

Itil.

J. Volavka

�REG

Evarott Elliuwood,
Turan

Itil,

0?

DRUGS

0F ABUSE

Associata Professor
Univsrsity School of Modicins

M.D.

Duke

Professor of Psychiatry
University of Missouri School
of Modicins (St. Louis)

H.D.

Assistant Profsaoor Psychiatry

Jan Volavka, H.D.
Max

Fink,

Nan York Madical Collcga

Professor of Psychiatry

M.D.

Now

York Medical College

The workshop will raviaw tho affects of alphstaninas.
bansodiasapinas. barbiturates, opiates and cannabis on 356:
acute and chronic administration, toleranca and cross-tolerance.

antagonists,

and dosagc

relations.

�</text>
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                <text>1970 </text>
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                    <text>March

20'

1972

Professor Edward Carrot:
University of Florid:
Goinosville, Florida 32601
Dear Dr.

Garrett:

As a member of ASCPT, I received an announcement of the
Third International Symposium on Clinical Pharmacology in Rosanaburg, Germany to August. I am enclosingoan abstract entitled

"Classification of New Psychoactive
for your consideration.

Drugs by

EEG

Profile Analysis"

Thank you.

Sincerely yours.

as: Fink,

21.23.

Profosuor of Psychiatry

�</text>
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                    <text>March 20, 1972

Hr. Abram Engelman
Conference Coordinator

Co-director

Center for Social Research
805 N. Charles Street

&amp;

Action

Baltimore, ﬂaryland 21201
Dear Mr. Engelman:

We have read with interest the announcement of the con~
ference examining methadone substitution therapy. Because we have
been seeking alternatives to substitution on drug—free programs,
we have studied the possiblilities oianarcotic antagonists. Since
the announcement is cryptic, it is not clear to what extent the
examination of methadone and its alternatives is socially or clin—
ically motivated. Should the focus be clinical, we would be inter—
and would be able to discuss two issues:
ested in participating
—

1)

Pharmacological aSpects of methadone and long-acting
methadols (alphamethadyl) in maintenance.

2)

and issues in the treatment of
with
narcotic antagonists.
opiate dependence

Clinical experiences

Should these be of

participate.

interest,

one of our

associates can

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

Ming

�</text>
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                  <elementText elementTextId="106377">
                    <text>~¢ w

Julian

an

«mmyvﬂww? rsavrm»

,-——-‘—'7- -

K

«ww—
«rm-«paws-»-mwv-n.-rmwrnwrwwwmnr

vw4

v
w

Eof:

""1me

Dear Jack,

w:

n—u-

”win-VW'.‘

W.Vv—¢A

.

WW

Wu...

.—

om,

y'w

--

ww-V ,r

~

"W,

,

.

EXHER

M323152~01

AM lo the proposal, ”Malamute of Schizophrenia by
E .3" has imartmt and interesting goals, the methods

".7,me

wuw—

-

March 23, 1972

E. Laoky, Phi).

Hational Institute of’Mhntal Hoalth
Bookv’llle, daryland

.
.

wvw-va,

Regressive
are
inadequate to tho task. Should ﬁlm Committee wish to encourage such
a program, it would lo advisable for the investigators to diamos
two isouao with otz‘zoro: tho lrztomlatimzo of modifications of the
363‘ prooeoa to therapeutic outcome, and the; isouaa in quantification
of the EEG. In Million, since the min «Issues in regrosoivo EC'T from
a public hoalth point of view are the long Mm affects of multiple
seen as an aaeault on the central nervouo amt-om, particularly
“lama,
on masuree of brain Motion and on such oapaoitloa as concentration,
mmry, and thought prooooaoa, the evaluation of nouroZOgloal deficits
and poyoizologéoal taste focusoad on what is usually called ’organioity’
must be considered.

“.I-vv‘wrrnr—y

investigators have done an interns ting clinical study
in oohiaophranio patients. There is a need for such
a ra-evaluatt‘on of regressive 3‘02”, for this modification has a chequered
history. Older atudiee fomd it rarely useful. Recent studies of multiple

of mgroealve
‘

,
am

mzwwnmvvvmwmw

«A;

A-"ﬁz'sv

362’,

The

EC?“

under oxygenation control,- kave indt'oatod

safe, pmduaing no

that multiple

ECT

are

mmry lose, nomlogioal deficits, or EEG
changes than slnglo E63". Unfortunately, multiple E02” only occasionally
produces better results than Mingle ECT in depressed patients. Tho data
for schizophrenic patients is unclear, hmwr; and than now are some
reports of better results: with multiple E’CT. Thaw data mantra verthe proposal 2):; Row:- warrmta some
ification, and in this
assistcmann its present form, it is inadequate to the make outlined
by the investigators, and suggostod by my view of the public health issues.
more

erk,

favorable features of the proposal:
is adequate, and the setting is probably a good one for
such studios. (In our investigations of ECT at Gracie Square and Hillside,
was in those small hospitals that the staff were favorably diaposed tp
it
EST, allowing the investigations to proceed.)
The

1) the population

2) The investigators have an

interest and

some

experience in rograsaiva

EC’T.

�EXNE’HOOIOIIOOIOCOOOOODCOIOOIOOQII

2.0.00.00090000. We}: 33’

1972

3} 2%3 PI ochibits statistical and doeign sophistication, and his
rocord as pcychomotrist is good.

Iﬁo negative fhaturoc

of'tho proposal:

1) The aeaign is ECT vs. drug treatmont. This £8 not the most important
locus, but were it the doslgn to be followed, there are specific problemc.

2)

change

Wﬁile the evaluation mothodc may be adoquato lndicoc

in porconallty and behavior, the issue in gogroacivo

ECT

of

is the

impact on lntorporoonal behavior, neurological dcflcltc, thought
processes, momory, and cmontraoion. In their first study, they
emphasize a porcictonce of’somo of’tho thought disordcr~u but is
it difforont and how is changed ? The clinical aspects seem inadbquatcly
covered, and the omphaois on a psychiatric interview no less than 30
mdnuteo and no more than 45 minutoo is mochaniotic and loos than helpful.

it

ovaluction is at thoworong time for any important
ghoulﬁ be evaluated coriatlm (weekly) to assess
tho rate and dogroo of’chango in brain function. But wool critical
is the likolikood that the patiouts will all rooeivc drugs aflor the
treaomont oourso. Yﬁo druggcontrolc of'nocoocity; the EC? patients
most probably. Slﬁoo no statcmont is modo about the specific drugs,
dosages, and relation of EEG measuroa to drug intako, I have to asaumo
the investigators are not acutely awaro of'thc impact of'drugs on the
EEG. To unravol EEG effocts of ECT from drugs without attention to
the controls necessary, is exceedingly dlfflcult.
Iﬁo

EEG

issue. Porhaps the

EEG

fﬁe samo problem in the evaluation and followmup will
what {a the impaco of’drugc given after
EU?
tho
EC?
on
rogroacivo
prococc, and on the compariaoo of'ECT and
drugo 7 (For thio reason, I would favor rogrosolvo ECT vs single ECT).

occur for other indicoc~~

Patient selection is

3)

XII-Mr.

,

an

issue.

The statement of’procoas
doccribad are too nan~spcciflc

schizophrenia is inadoquato.
tests
to help othera define tho population. It were better for the investigators
to specify which criteria of’prococc schizophrenia thoy use (3.9. Fish,
Eoylor, others ?). Paychological tests are supplementary~~ they cannot
be used as the diagnostic critcria.
Too

criteria

on

while I'am not ordlnarily prone to question selection
ethical groundb, in this instance, the authors should be

asked to make clear aomo of'thcir minimum criteria of’prior treatments
and failure, recent treatmont and failure, etc. bcfbro rogrcssivo ECT.
Should not all pationtc have had a course of”rcgu&amp;ar' ECT and failed ?

Poychological teats arc given heavy emphasis, but the
more selected in not indicated.
Why the MMPI and the SRSC ? Noithcr is aulecicntly speciflc in its
interpretation to be very helpful.
4)

theoretlc bass from which these touts

�EXNEktiioﬁioIOODOOOOOCDIOOIOOOCO

3

OUOIOQCOOOOOCO‘IOIOOWh

I)

There are many problcma with the
the ctudy could be done without EEC moaaurcc,

EEG

33’ 1972

measures, but cincc

I will not

go

into full

datail of’thcinadbquaciac. It to not clcar why the invcctigatorc are
measuring E33 affccte, for the only specific suggestion comoc from the

dhscriptéon of’lack of’abncrmallty bcfbro and after troatmont, as
evaluated by tho neurologists on visual lncpcction. Etc issues
that could be investigated are the difycrancca in EEG offhctc of
rogroscivc EU? to other EZﬂk the rate at which the induced changes
disappear; the relation of‘changa to improvement, to memory cffhctc,
or to other neurological indlccc.

They cuggcat quantiftcation cf'thc Eﬁﬂg suggesting
rocording and analysis for chart epochs. Tﬁc equipmont they
request, rcprccenttng a large part of'thc budget, to adoquatc only for
the analog to digital conversion, and some simplc ctcpc of'data reduction.
But EEG data it voluminous, coon when reduced, and the interrelations
among many chancclc a horrcndouc tack. (Ihdocd, vary for investigators
have challenged more than one or 2 channel data, and tf’morc, only for
1 0r 2 minute cpochc).
8 channel

Their interest in sleep EEG to unjustified in the protocol.
cbcn suggest sleep EEG recording (8 hours), for 8 channels (I),
to so voluminous a tack, tkat I cucocct tlcy do not moan this.
suggestion about doing visual analytic of'tha sloop records to
interacting, but this too to a big task) and will not in thctr
for cares, answer any of’tka quattcac. The same problem of'drug
control must be considorcd hero.
Eb

thir

I

10

l

4

1h rcwrcadﬁng thic proposal, I believe the investigator
bringo to the questions, posed by his clinical colleagues, and cxpcrlcncc
at a clinical psychologist and psychometrtctan. Those aopcctc scam well
handled. For ’ccicntlfic' reasons and interacts, they are suggesting
EEG analyses, sleep recording, and some fblloa~up studies. It these
aspects, they team to lack experience, but alco cuffictcnt judgmont to
visualize the tasks and to obtain advice. Earhapt, more they encouraged
to visit and work with one of'thc untoercity based centers studying
EC? and on: focuccad on quantification of’thc EZEQ these issues might
become clearer to them. ware they then still interacted in the studies
auggoatcd here, a better propoaal might (?) to fbrtkcomtng.

to a clinical
better atatamcnt of the
population, assessment of'ncurologtcal chhcto, control of'ECT paramctarc
and drugc, ctc.~« and a contribution madc to the EC? literature. In the
Alternatively, the dcctgn could

replication of their pilot study, with

some

be reduced

latter case, the budget could to subjected to rcqorktng; dblcting
sleep and statistical consultants ($8300), equipment ($30,300), and

E36

chart paper ($600); with additions for neurological evaluation.

I trust those comments are helpful. you already know the
laboratories
interacted in those iccuac, and I am confldont
principal
that any would be interested in this study.
Stnccroly yours,
Max

Fink,

MI

D.

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                    <text>usxonannux

March 24, 1972

Mrs. Ebert

T0:

—

EH34:

Dr. Max Fink

SUBJECT:

Painting

As

per our

memo

Maintonance

of March 15. requesting painting of room 42A

and Lab 42A; please add to

5;, to b. painted in the

this request,

same color (very

room 42 and Agboratogz

light blue).

Charge 39-270-0.

‘.

.
'l.\.u

.—

,-V.‘.\4

‘

MiaLh—h‘

‘

I
*Wkﬂgiﬁw

�</text>
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                    <text>Match 27. 1972

0:.

Leo E.

Hollistor

Veterans Administration Hospital
3801 Eiranda Avenuo

Palo Alto, California 94304
Dear Leo:

the cannabis oynpooiun
will be plotted to participate in We
1972.
will provide an
of tho 813? in Copanhagon. August 17,
We

abstract
in

to be provided

on the forms

by Dr. Jacobson.

can prepare a printnready manuscript for Copenhagen.
August within space limitations you may suggest.
We

to than.

As

Dru. Stefania and Hires. I have soot your questions
Thoy should answer you shortly.

for

For tho

listing,

our presentation should be

"Behavioral and

EEG

TXIC"A"9" o

titled:

Effects of ﬁaxijuana and

mxﬂm,&amp;m,LVdmh,mm,quMWMMPmm.
M.D.
M.
Frooéman.

and A.

Department of Psychiatry,

title
list:

The

you

York Hodicol Collego

and co-authora of the Stofanis«ﬁiro3 prosontation

should be deforrod.
may

ﬂow

Provisionally (subject to thoir approval),

"Studios of Chtooic Hashish Users"
Costa: Stefania, M.D.,

A.

Liakoo. M.D.,

Costco Miran, H.D., and Mn: Fink,

University of Athens Ind

Row

Md).

J. Boulougoris.

York Modiool Collage

M.D..

�Dr. Leo E. £10111:th

March 27, 1972

I look forward to this interesting session.
Sincorcly your! .
Max

Fink.

24.1).

Frofenor of Psychiatry

14ng

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                    <text>-., ‘4’

-1

,

,

w .V ,... ,4 Fuvvrv 'Vmw,lr.“fme-v‘mnrt"n

n"...

and

...-,

«.

_.~...wv.¢.—.v_-_ wavﬂ'.’r--;_

.....

.,

.r w,

.V V.» ..

\vrwdr‘J-s-(uxwr'w-z

-»-..

mu» .m.»

»-.~~ ‘1

March 27, 1972

Donald Gallant, M.D.
Professor of Psychiatry &amp; Neurology
Tulane University School of Medicine
New Orlean, La. 70112
Dear Don,

I read your impressive ECDEU report with interest-~
particularly the data on GR? 8063 and the neurophysiologic studies.
But one issue stood out, that of the EKG effects of thioridazine.
You report extensive and persistent EKG effects of thioridazine and
meaoridezine. In our studies in St. Louis, Turan and I were also
impressed with the EKG effects of thioridazine, in ﬁber studies of
chlordiezepoxide and thioridazine.
This data becomee even more important when we review the
data
clinical
for thioridazinc, for this compound is no better than
other ontipeychotic drugs, and occasionally has been rated as worse.
Why,

limited to the

then, is the drug not withdrawn; or, as with iproniazid,

few cases of confirmed therapeutic failure with other agents
ECDEU
Perhaps the
group could discuss this question in Spring Grove
in June, and if other investigators agree, bring the data to the attention

of the

FDA.

Or, do you

changes are so trivial as
functions in these patients!

feel that the

not to affect the cardiovascular

EKG

I look forward to seeing you in June.
Sincerely yours,
Max

cc: gerome Levine, M.D.
PRE-NIMH

Fink, M.D.

?

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                    <text>Matéb 28, 1970

Thomas McClashsn, &amp;.D.
Program Head
HIMH - RM. 9m101

5600 Fishers Lane

Kockvills, ﬁsrylsnd 20852

Dear Dr. Moﬂlsshsn:

associates

anticipate our participation in tho
invastigstors in Spring Grove.
1 do not know if we are ”due" for an individual presentation. If
so, the enclosed summary will be elaborated.
Hy

and I

June 5, 6 meetings of the
Should

stract it)

it

for the

ECDEU

not be "dun". you
ECDEU

Intercom.

may

wish to use this (or sb~

it be appropriate, I would be pleased to send this
to the present list of active ECDEU investigatiors and committee members, if you could supply as with this limited list of
Should

summary

nsmss and addresses.
Many

thanks.
Sinner-1y yours,
Ha: Fink, ﬂ.D.

Professor of Psychiatry

HF:ig
than

�</text>
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                    <text>Hatch 30. 1972

Dr. William Blackmore

Sterling Winthrop Research

Institute

Reusaalser,

ﬂew

York

Dear Dr. Blackmore:

Enclosed are case reports of patients inducted in 1971,
to be added to our files at the Institute.

Sincerely yours,
ﬂax Fink, ELI).

Professor of Psychiatry
Mfzig

Ens.

-,
n.‘

�</text>
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                    <text>ﬁarch 31, 1972

Dr. Geoffrey Woodard
12310

Pinecreat

Road

ﬁclndon, Virginia
Dear Dr. woodard:

files, we found the enclosed reprints and
us by Racket: &amp; Colman in 1970. These may be useful
in your evaluation of H-5050.
In checking our

raports sent

The letter of authorisation
sent earlier this week.
we

look forward

ta hearing

and our supply of M—SOSO‘wére
from you.

Sincerely yours,
Fink. H.D.
Professor of Psychiatry

Max

ﬂF:1g
Enc.

�</text>
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                    <text>ﬂarch 31. 1972

Dr. Sidney Archer

Sterling winthrop Research

Institute

Reusaeleer.

ﬂew York

Dear 51d:
thanks for your hospitality and the fine dinner on
I have already written Bob about the changed concentration
of cyclazocine, and discussed with Al Freedman our possibility of
finding the animal toxicology of £~cyclezoc1ne pamoate (or enonthato).
Should we get any encouragement, we plan to ask you to plepare this
material for us.

Monday.

Many

'

I also enjoyeé our discussion of antieen31ety agents. Per~
haps you would be interested in this small reprint. As it was re”
troapoctive, we were unable to assert we have observed tolerance
development, but I believe the data supports such a View.
ﬂy

best regards.
Sincerely yours,
ﬂax Fink. M.D.

Professor of Psychiatry

53:15

�</text>
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                    <text>March 31, 1972

Jean Paul Smith, Ph.D.

Division Narcotic

&amp;

Drug Abuse

ﬁational Institute Mental
Health

Fishers Lane
Rockville, Maryland 20852
5600

Dear Jean:

all our reprints relating to diprenophlina
enclosed.
capies are
We have sent 10 ﬁt::;?ﬁ*5050 to ﬁr. Woodard for animal
toxicology studies.
I otzﬁzrlhe
will be helpful.
He

(ﬁvSOSO);

have collated

reprints

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

HF:1g
Enc.

�</text>
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                    <text>Docenbcr 3, 1971

A. Grace

Picrcc,

H.D.

Associate Director of

Clinical Rasearch
Ortho Rnsoctch Foundation
Raritan,

New

Dear Dr.

Pierce:

Jersey

08869

1 look forward to seeing you on Wednesday morning at
I have received the description of ORF 8063 and look
forward to discussing this with you.

11 a.m.

Much of our work is focused on a dcscription of the
chanson induced by psychoactive drugs. In anticipation of
our discussion, I an mending you'two recent summaries of our
work.
EEG

Sinccrtly yours,
Fink, H.D.
Profcocor of Psychiatry

Max

31:13
lhc.

,

�</text>
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                    <text>Docenbcr 3, 1971

A. Grace

Picrcc,

H.D.

Associate Director of

Clinical Rasearch
Ortho Rnsoctch Foundation
Raritan,

New

Dear Dr.

Pierce:

Jersey

08869

1 look forward to seeing you on Wednesday morning at
I have received the description of ORF 8063 and look
forward to discussing this with you.

11 a.m.

Much of our work is focused on a dcscription of the
chanson induced by psychoactive drugs. In anticipation of
our discussion, I an mending you'two recent summaries of our
work.
EEG

Sinccrtly yours,
Fink, H.D.
Profcocor of Psychiatry

Max

31:13
lhc.

,

�</text>
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                    <text>Dscssbsr 3. 1971

Dr. Jerome K.

Jaffe

SADDA?

white house,
Washington, D.C.
Dear

Jerry:

Roger called me about the problems in obtaining supplies of
cannabis and opiates for research. Our difficulties are long standing,
and are of two kinds * "approval” by an FDA-NINE Connittee that has ar-

roasted the responsibility to review the specific content of the uses and
to which applicants for drugs are making of their requested supplies;

actual distribution difficulties.
Since 1968,

we

have had approval from 31MB,

BNDD,

H.Y.

States

College to study cannabis
3.1. City, and the appropriate committees of our from
scientific committees
and heroin in man. we also have fornal support
[psychopharnacology],
(N.Y. Stats ﬂacc~contracts since 1967; Nlﬁﬁ 13358
18172 [cannabis], and 19h76 [heroiu]l(
Yet, when we request supplies of cannabis, us are again asked
supplies
to submit formal proposals for committee review. Not only are
the Con—
of
the
prejudices
reduced
to
according
and
the
aaounts
delayed

their arbitary decisions. For exnittee, but our intent frustrated 21bydays
of marijuana use in man would

ample, in June we were told that
dsensd
not be allowed, but 7 days would be; and in September, the Committee
made
in
21 days allowable for all investigators. Such reviews are not
the
any other drug study we usually depend on the investigator to assess
the
by
risks and the needs of the study progrsn, and rsquirs monitoring
appropriate connittsss of his institution.
—

It is

ny

belief that the

Committee ought

to restrict

its

func~

tions to advising the Secretary of HEN about the distribution of those
drugs which are in very limited supply - to evaluate the priorities among
of the nation.
scientists who nay have special calls on limited assetsshould
be freely
the
distribution
ample
supply,
But where drugs are in
made to those scientists who have eat the standards of research and infor which drugs
stitutional monitoring approved for the specific studies
pious reaare requested. The assumption by the Committee, for whatever
to drug
deterrent
severe
is
a
of
proposals
the
content
sons, to critique
study.
and
fruitful
inhibited
and
both delays
research,

�Dr. Jerome K.

Jsffs

Deceabsr 3, 1971

Tho sscood issus is that of the supplies. Ones spprovsl is
tho
givsn,
suppliss srs distributsd in obtuse snd sxpsnsive ways, with
suppliss dslsysd and lost. On two occssions, horoin hss been sent through
the osils sod hsvs been lost. Prior to the roosnt sssusption of distribution by BRDD, ths drug was dalivsred by so sgsnt of tho Justice Departssnt sod whils it took months to obtain suppliss, thsss did svsntuslly
arrive. ﬂow, it tskss months to 3st sporovsls and suppliss come only
site: rspostod cslls.

Incidentally, so sro embarking on tbs spooisl study which you
othsrs hsvs rsqusstsd that of tho duration of action of ssloxons
pssosts. Us hsvs no hsroin on hsnd, sod dsspits roqussts since tho sod
of August, sad submission of tho oscssssry docuosnts, us will be forcsd
to carry out thsss ssssys with inputs substancss. Porhsps your attics
could call BNDD sod srrsnss for s ship-sot of 1 Grss for the iossdiste
uss, psoding tbs usual longthy procsss for 5 Grsoo?
and

—

Sincsrsly yours,
Pink, M.D.
Professor of Psychistry

Max

33:13

�</text>
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                    <text>December 6, 1971

Dr.

Christer Meissner

Ciba-Geigy

AG

Basel, Switzerland
Dear Dr. Meissner:

Enclosed is a copy of my report to the World Congress
of Psychiatry, and an earlier report which describes more fully
our latest findings. I trust these will be helpful.
and

I

Our studies of GP—41299 will be completed by February,
hope these will be interesting.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Ming
Ehc.

�</text>
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\\

December 6, 1971

Mrs. Barbara Gibbons

College Department

Holt, Rinehart and Winston, Inc.
383 Madison Avenue

New

York,

New

York 10017

Dear Mrs. Gibbons:
my

I have received your request for permission to reproduce
1970 on narcotic antagonists in a popular

reprint of September

volume by Matheson and Davison.

This summary is incomplete as a reflection of the role
of narcotic antagonists in opiate dependence. Perhaps a more
complete summary, appearing in the American Journal of Nursing
(71: 1359—1363, 1971) or another in press, may be more useful.
If you will send a copy of the table of contents, it may be helpful to decide my response to your request.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

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                    <text>Deco-bar 6, 1971

Ir.

Seymour Piahar
Univoraity Hoapital
750 Harrison Aronua

Boaton, Maltachnootto 02118
Dear Seymour:

Enclosed are copioa of the Quootiono and Annuora portion
of the forthcoming icauo of Shainaro in Poyohiatiy devotod to
ECT, aa raquaatod by Ernest Hartaonn. I have no objection to
your tending this draft to several interoatod workers. with the
idea that their comments may appear in a later issue of Seminaro.
As an oxporinont, it cocoa quite
look forward to the comments.

interesting,

and

Sinccroly youra,
Fink, H.D.
Profoacor of Psychiatry

Max

cc: Brnoat Hartmann, H.D.

I

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                    <text>Decaubor 6, 1971

Arnold

J.

Mandall, M.D.

Profoaoor and Chairman
Dopartnant of Psychiatry
Univaraity of California

P.O. Box 109
La

Jolla, California

92037

Daar Arnold:

It waa kind of you to writa about 8-2809, a bill sponaorad by Senator Tunnay. I had read thia bill before and found
its intant coat worthwhile. Tho meant, however, carry two potential (and unnecessary) pitfalla - a focus on a limited number
of ragioual contort, and tha incroaaad focua on a political aourcc
of control, notably the white House.

copy of my roaponaa to Senator Tunney is enclosed for
inforlation.
At this time, support for the aatabliahnant of a national
A

your

institute for drug abuse raaaarch and training seams to be sorely
noadod. Sanator Tunnay'a bill ocean to diffuae tho energies foam
this important effort.
Hy

boat ragards .
Sincoraly yours.
Max

Fink. H.D.

Professor of Psychiatry

Ming
Ibo.

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                    <text>Deco-bar 6, 1971

Dr. Ivsn Bennott
Ely Lilly Company

Indianapolis, Indiana

46206

Dear Ivan;
Enclosed or. copies at my requeot to Karo: Bentonnn
reply. If you can support our request, perhaps you would
sand those on to Avram Gold-coin with your con-onto.

and hi5

Many

thanks.
Sincornly youro.
Max Fink, M.D.
Professor of Psychiatry

MI:13

Inc.

�</text>
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                    <text>December 6, 1971

Dr. Stanley Feldetein
2700 Ken Oak Road
Baltimore, Maryland 21215
Dear Dr.
and

reldatein:
Voita has kept very busy with the EEC-cannabis analyeee

is finding very interesting correlations. Indeed.

claina that there

may be an EEG—behavior

correlation!

he now

The heroin project has been held up by a shortage of
heroin, but I wrote to Jaffe in the White house and sea told the
eupply would be available on Monday. The project will then start.

you, but

I not Kurland in

is

Mexico City and he remembered meeting
he
heels
not sure
help.

Encloeed is the health and accident policy it the as~
satiation. Should you viah thia coverage after January 29, you

may

elect to continue.

I here received my pilot'e licenae - and it has given
Inch
pleasure. I was fixing today and look forward to an excuse
II
in the spring to visit Baltimore.
My

best regards.
Sincerely yours,
Max

Fink, H.D.

Professor of Paychiatry

MF:ig
Enc.

�</text>
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                    <text>Docsabsr 6, 1971

Dr. Garry F. Blane

Rsckitt &amp; Col-an
Hull , England
Dear Garry:

Ho bass rscsived the supply of storphins.
undsrtaks our studies rapidly; many thanks.

We

will

Thsrs is much enthusiasm for an sscslation of rssaarch
in the narcotic antagonists. Ha hsvs, this vast racsivsd a supply
of naloxons psaosts for study; and l~cyclasocins is now in suffi—
cient supply for human trials bsginning next south. I an opti—
aistic that we will obtain funds for toxicology, sufficient to

file

an IHD.

Again, sy thanks for your hslp.

Sincsrsly yours,
ﬂax Fink, M.D.

Professor of Psychiatry

3311;

�</text>
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                    <text>Deco-bar 6, 1971

Ivan K. Goldberg. M.D.
929 Park Avenue

New

York,

ﬂow

York 10028

Dear Dr. Goldberg:

I an grateful for your invitation to participate in

racording for the Behavioral Science. Tape Library. It is unclear
to no vhat subjects you with represented, nor is it clear what
bonafita may accrue to no for my services. The work of this division
is very broad, encompassing ECT (both clinical and experimental),
opiate dopandencc thorapy. cannobio effects (acuta and chronic).
and BBC offoctn of psychoactive drugs. Such a progran is actively»
pro-outed at national and international meetings, and could servo
the library.
However,

it

is not clear

how

this lecturer

may

benefit;

not is it claar whatnot the talks are to be proacntod informally
or formally. Perhaps you may wish to consider another financial
arrangenont, an a fixnd sun for the nation and a lesser "royalty"
for aach subscription?
Sinoaraly yours,
Max

Pink, H.D.

Protaalot of Psychiatry

HF:ig

�</text>
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                    <text>December 7, 1971

3r. Jerome Levine

PsychOphermacology Research Branch

national Institute ﬁentel Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Jerry;

Your suggestion that we hold A ”working session“ on
the subject of quantitative EEG and psychophermecology is excellent,
and I will prepare as detailed a presentation as may make the
discussion most useful. In thinking about participants, I had e
number of suggestions.
From psychopharnacology

I believe Jonathan 0. Cole should

be present, since his interest and enthusiasm has sustained
program since its inception.

this

For a formal knowledge of EEG and drugs, Peter Kelleuey
of Houston, Robert Ellington, and George Ulett are highly qualified
elactroencephelogrepners who arc not now active in drug evaluation.

Turan

Enoch Galloway, Charles
Itil,
active interest in EEG and

have an

Shegess, and Arthur Sugornen

drugs.

general psychiatry, I would suggest Seymour Katy,
Jool Elkes, aorton Raiser, and Denial Freedman be

From

Al Silvoruan,

considered. none have e formal knowledge of our work, but their
roles as ”generaliets" ia well defined. I anticipate they would
be Both interested and contribute to the review.

From clinical psychophamcology, Prita Freyhan, Heinz
and
Leo Rollieter ere activo clinicana who have a broad
Lehmann,
interact and experience. Leo has had e special interest in EEG
and has consistently failed to find the correlations we have re~

ported.

�Dr. Jerome Lorine

Decaubor 7, 1971

Along the statistically sophisticated with a special
knowledge of the problems of reducing large scale data, you may
considar Allan Miraky (Boston). Ron donate, Dean Clyde, John Overhas had a special interest in EEGall, or San Sutton. Kiraky
knowa
bchavior ralationa, he
our work, and is an intoreated critic.

thin type of work, Abraham Hinkler
should be considered. It was his 1952 theory that set no on thin
study route. Since then, he haa criticized my data, noting that
we "ovar—aiuplify" a vary complex subject. He has not dedicated
as Inch time to quantification as 1:11 and I, and in 1966 he participated in tho anticholinergic drug symposium with much enthuFinally. the

aiaam.

“daan” of

‘

I look forward to this session with great interest.
Sincerely yours,

m:

Fink, 3.2).

Professor of Psychiatry

Hing

�</text>
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                    <text>December 7, 1971

"‘0 :

IBS

FROM:

Max

SUBJECT:

Service Functions,

On

and

Fink,

M. D .

Ward 15A and OPD

basis, we admit 400 patients for observation
these, about 100 receive further treatment,
continue in our aftercare program.

an annual

detoxification.

on methadone, and

Of

The detoxification procedure follows the established
techniques of reducing dosages of methadone, requiring 7-14 days
observations. Aftercare consists of meetings with rehabilitation
counselor, social worker, and education Specialists, as well as

individual
older,

and

and group psychotherapy.

Admission

is restricted to males,

residents of

New

York City.

18

years of age and

The average a patient stays for detoxification is 9 days;
for methadone 60 days; and cyclazocine 30 days. Outpatient stays
varies for 1 month to 6 years to date.

During 1971, we regularly cared for 100-110 patients in
seen on the average 2—4 times each week. A sample month
runedown (March, 1971) is attached. In addition, we respond to
consults regarding drug abuse on 123, l3ArB, and all of metropolitan.

the

OPD,

H03pital.

,tgg14

r m.

7-.

,n.’

.4.

.Vt.,.s_..ea- .i

1‘5“»:

a».._":§$‘

ar...

7'.

¥

�TO:

188

those on

December 7, 1971
The
~

professional staff treating these patients includes
rate of $199,081. (List attached).

067, at an annual

In addition, the research staff, supported by ME 18172,
19176, 13358 and 47—072 Spend varying amounts of time in the studies
on 15A, including heroin-antagonist research, cannabis, and EEG.
On an annual basis, these sums are:
S

47—072

Personnel

2 15A

257,123

69%

13358 (41-382)

39,700

10%

18172 (41-435)

44,300

40%

19176 (41—452)

28,164

50%

(Est)

�STAFF AT 15A

-

MET ON

067

Annual

Geyer

Social Worker

$10,560

Orlin

Social Worker

11,890

Psychiatrist

14,666

Gaztanaga, P.

Psychiatrist

20,000

Jones, T.

Internist

12,600

Levine,

Psychiatrist

25,000

Maior, V.

Psychiatrist

19,250

Montese

M.

H. Worker

7,865

Resnick, R.

Psychiatrist

14,000

Clare,

G.

R.

Reuben,

J.

Psychiatrist

19,200

Taylor,

M.

Psychiatrist

25,000

Psychiatrist

18,050

Zaks, A.

TOTAL

$199,081

�</text>
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                <elementTextContainer>
                  <elementText elementTextId="106362">
                    <text>December 8, 1971

T0:

135

FROM:

Max

SUBJECT:

Space at 102nd

space at

I

am

Fink,

14.1).

Street

writing to request your review of the allocation of
Street.

102nd
When

Dr. Crown joined

my

staff, it

was only possible to

office to share with Dr. Volovka because Dr. Feldstein
my
service. Since he shares an office, both he and Dr. Volovka
left
rotate their time here, with one frequently doing his work at the
Academy or at home.
assign him an

Dr. Marvin Glasser is an appointee to NH 13358. When he
worked on the 4th floor he was able to participate directly on my
work. Since August, he works in Valhalla, and is of little use to
me

or

office

my

associates.
Similarly,

—

a

when Dr. Shapiro comes

possibility only if I leave.

to

New

York he uses

my

Drs. Taylor, Abrams, Levine, and Gaztanaga are interested
in working with me. Since space at Metropolitan is not available,
and none here, we carry out our discussions by telephone - a procedure that is of little use.

I request the assignment of rooms 34, 36, 27, and 29 to
the Division, for as many months as we remain at 102nd Street and
until another resolution at 106th Street or MHMC is found.

�T0:

December 8, 1971

IBS

Personnel at 102nd Street

Professional

ReseareﬁiAssistant
R

Crown

Full

Time

Greenberg

Full

Time

Dornbush

Full

Time

Komlosi

Full

Time

Tolavka

Full

Time

Maxym

Full

Time

'h'aynor

Full

Time

Richman

Full

Time

Glasaer

3 Days

Pavel

Full

Time

Shapiro

2 Days

Garcia

Full

Time

Fink

Full

Wells

Full

Time

Abrams

1 Day

Snapper

3

Taylor

2 Days

Levine

1 Day

Time

6.8 Full Time Employees

(McNiff)

Days (FT

Evening

if

Glasser

were here)

7.6 Full Time Employees

�</text>
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                    <text>December 9, 1971
Dr. Robert Rees
SAODAP

The White House

Washington, D.C.

Dear Bob,

are pleased to enclose a protocol for the study
of narcotic antagonism
of l~cyclazocine~- to assess the degree
in post—addicts, and the relation of an effective 'therapeutic'
while we will be preoccupied with
dose to secondary effects.
we believe
our studies of naloanone pawste during the next few weeks,
the middle
about
beginning
we can evaluate this compound concurrently,
of January.
This protocol will be submitted to the appropriate
committees of the College for their concurrence, but we anticipate
We

no

difficulty.

Should the supplies be available,

is a choice) to

have

we

would

l-cyclasocine presented in the

scene

(if

there
concentration

prefer

and the scene vehicle as racemic cyclasocine. If manufacture is no
problem, we would request an initial supply of 1200 mg» sufficient to
assess the effects in 8 patients for 4-6 weeks.
Many

thanks

for your cooperation.
Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

mf/
V

:rar

:

.

�</text>
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                    <text>December 9, 1971
Mr.

Stingley

111

Fifth

Grme s Stratton
ﬂew

Avenue

fork City

Dear we

Stiﬂgl‘y,

Enclosed are the corrected gallsys for the Introduction,
and
Question
Answers, and the reports by Abram, Dornbush, Fink,
Small 6 Small, and Volavka. Only the reports of Pitts and Rattan
remain to be corrected and returned.

special handling.
and
the
set off from
Wars,
bold
be
in
done
by setting the questions
this my
face or italic; or
the Q and A before each paragraph can be reset in bold face. At the
least, there should be additional spacing batman each set of Q 6 A.
As we

we

discussed, the

Q &amp; A

would prefer the questions to be

requires

some

I was

chagrined by the high price charged by the
reprints, and I an enquiring whether a special price
publisher for
be
arrived at for a single order of 100 reprints of each article,
can
paid for by me, in gratitude to each author for his contribution. I
would appreciate your response. Alternatively, if reprints were not
ordered, but whole issues, what is the price for additional copies
to the Editor 7
Secondly,
100

send the
I will
the authors

received from

Many

two missing gallsys as soon as they are
with their corrections.

thanks for your assistance.
Sincerely yours,
Mac:

Fink,

31.1}.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106360">
                    <text>Decauber 9, 1971

Dr. Margaret Tripp
45 Canbridgc Road

Colchostcr, Essa:

England

Dear Dr. Tripp:

the

would appreciate a copy of your curriculum vita: and
of at least two reference: to whom we may write. We would

We

names

prefcr lottera
and

psychiatrists.
There are openings in this Department at various times,
I will do my best to process this application in time for the

spring

_

April

from

1

or

Thank you

Hay 1.

for your intarcst.
Sincerely yours,
Mar Fink, E.D.

Professor of Psychiatry

HF:13

�</text>
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                    <text>Decauber 9, 1971

Dr. Margaret Tripp
45 Canbridgc Road

Colchostcr, Essa:

England

Dear Dr. Tripp:

the

would appreciate a copy of your curriculum vita: and
of at least two reference: to whom we may write. We would

We

names

prefcr lottera
and

psychiatrists.
There are openings in this Department at various times,
I will do my best to process this application in time for the

spring

_

April

from

1

or

Thank you

Hay 1.

for your intarcst.
Sincerely yours,
Mar Fink, E.D.

Professor of Psychiatry

HF:13

�</text>
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                    <text>Danube:

To:

9,

1971

Sylvia Faulkner

m: m Pink,

my.

Plano "NEW the maintenance contract for the Pridcn calculator
for one you, affective 1/1/72
Charge (46-12241)

W.

@

$110.

�</text>
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                    <text>Deconbor 9, 1971

hirooni Iohlzakl, 5.2.
Instructor

M.D.

Doparrnon: of Neuropoychiotry

Knnooi Modicsl School
Oooko, Japan
Door Dr.

Inhizoki:

I regret that we are unable to process any opplicotious
for positions in EEG rooearch at the present time, and trust you
will be able to find a position in Germany or the Soviet Union ~
both countrtloavhioh are actively seeking students.
Sincerely yours,
Ha: Fink, M.D.

Professor of Paychiotry

HF:13

�</text>
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                    <text>rw—w—“Wm

w mu -w

-

,

December 9, 1971
be».

Stingley

Stratton
Fifth Avenue

Grune
111

IJew

5'

York City

Dear Mr.

Stingley,

Encloud are the corrected galleys for the Introduction,
Question Md Answers, and the reports by Abrams, Dornbush, Fink,
Small ‘3 Small, and Volavka. Only the reports of Pitts and Essman
remain to be corrected and returned.
discussed, the Q &amp; A requires some special handling.
We would prefer the questions to be set off from the answers, and
this may be done by set ting the questions in bold face or italic; or
the Q and A before each paragraph can be reset in bold face. At the
least, there should be additional spacing between each set of Q a A.
As we

Secondly,

I was chagrined by

the high price charged

by the

reprints, and I am enquiring whether a special price
publisher for
be
arrived
of each article,
can
at for a single order of 100 reprintscontribution.
each
his
author
in
to
I
by
for
me,
gratitude
paid for
would appreciate your response. Alternatively, if reprints were not
ordered, but whole issues, what is the price for additional copies
100

to the Editor

7

I will send the two missing galleys as soon as they are
received from the authors with their sometime.
'

Many

thanks

for your assistance.
Sincerely yours,
Mas:

Fink, M.D.

Professor of Psychiatry

"mu—WM
.

�</text>
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                    <text>—~-

uncut-cm

.

u-

December 11, 1971
Dr. Paul Arcese
Sandos Pharmaceuticals

Hanover,

New

Jersey

Dear Dr. Arcese,

I have

read your

letter of December 8.

In our study of 5-42, 548, we assessed the EEG and behavioral
effects of single doses in normal mle volunteers. There were no
patients in the study. Also, we coupleted the pilot, 'dose-finding'
study only, and our recommended study of 5—42, 548 vs. placebo was
not done.

It is

probable that the synptoms reported by these men
related, or may have been a result of the situation.
The study is incomplete with regard to the definition of this
judgement. It is not possible, therefore, to list any of the
effects as ’sids-effects;,-nor is it possible to esclude the possibility
thta these reports are drug related.

may

have been drug

I am

therefore returning the reports-— first, because they
'; and secondly, because the required judgement of
drug related, not drug related, or uncertain cannot be Inade.
specify 'patients

Sincerely yours,
Max

Fink, MD.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106356">
                    <text>W»

Dacsubar 14, 1971

Paul Jansaan, M.D.
Janssan Pharaacautical Raaaarch
3-2340

Bursa . Bulgiua
Dear Paul:

It

Haxico City.

was a
Ha

plassura to boar your rsport and most you in
ars particularly intarsstad in narcotic antag-

ouiata. and art soaking a compound or formulation of long duration
with minimal agonistic fasturas. Dr. Canaron of tha W.H.O. suggaatad that you may have davalopod antagonists of high potancy
without agonistic fasturas.

If such coupouudo do sxist. I would be grateful for any
infatuation ragardiug their characteristica and availability for

study.

Should you praiar, you may wiah to bring such data to
the sttantion of our spacial drug abuse agaucy ~ Dr. Robart Rosa,
Spatial Action Oftica for Drug Abuas Pravantion, Whita Hausa,

Washington, D.C.
Any

ssaistanca you can giva our search (or a nora useful
ha appraciatsd. My boat rsgards to your charming

antagoniat will

Hits.

Sincsrsly youra,
Fink, H.D.
Professor of Psychiatry

Max

“:13
cc: Dr. Hobart
SADDAP

3...

�</text>
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              </elementText>
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              <elementText elementTextId="51322">
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              <elementText elementTextId="51323">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103599">
                    <text>December 14, 1971

Dale Cameron, M.D.
Commissioner on Drug Abuse

W.H.O.

Genera, Switzerland
Dear Dr. Cameron:

I

was very much

activities in

interested in your report

Your comments regarding analgesics
from Janssen were most helpful — I
discussed these with him, and we have agreed to share our data.
and

Mexico City.

on W.H.0.

antagonists available

I am enclosing some reports from this laboratory, of
our studies of the use of narcotic antagonists in opiate dependence, and the central effects of acute and chronic cannabis use.
The cannabis studies are in progress in New York and Athens, and
we have a proposal to extend the study to Jamaica.
Many scientists and clinicians from many countries have
visited our laboratories, and should W.H.0. desire to extend their
training activities, we would be pleased to participate.

Again,

my

thanks for the suggestion about Janssen.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Ming
Enc.

�</text>
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-

_//’1

pecan”.

December ]S, 1971

‘Jnn'ur-r-

-

.e—r—.;mwww,w-—a.r

Mrs. Roberta London, Mg. Ed.
Contemporary Drug Problems
515 Oxford Street
Westbury, New York 11590

.wmmwmw“””””

\~em.

Dear Mrs. London,
W's-"ﬁr”,

I have re-written the article on opiate dependence, under
the title, Treatment and Prevention of Opiate Dependence with Narcotic
Antagonists, and sent it to my typist, for delivery to you early next
week.
It is sent on the understanding that it will be included in the
1972
issue.
Spring,
As I discussed, it may be useful for your editors to con—
the
sider
invitation to some of the scientists interested in the
of
problems
drug abuse to your Board, and I suggested that you
consider Dr. Alfred M. Freedman, Chairman, Department of Psychiatry
of this College, and/or Prof. Stanley Yolles, Chairman, Department
of Psychiatry, State University of New York at Stony Brook. Both
these men ahve a long history of interest in the problems of drug
abuse and have maintained a balanced and theortically sound position
on most of the contemporary issues.

of Cannabis, will require
that for the antagonists. There
is so much research activity at present, that to be timely the article
should be prepared at the latest time possible to meet your deadlines.
Depending on the time of the year, you should re—extend your invitation
The

other

re-writing even

article,

Biology

more extensive than

about 10-20 days before the final deadline.
difficult to meet your request.
Good luck

It

should not be too

in your endeavor.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>"navﬁmizm‘m

«—

_x

n

r-n
V

m“.

.,_.,w—u—r—u'm
w—m warn.

.

vw.

V

‘

mun

.

,
raw“

u.,-

[rs-raw

nr-"~',—-'rVr

.. v ”duh".-

..

v

v. .m.

*‘ “UV—r-

-~-

ww—r

v

m

.— m-I

--

an."

. q

.»

U'JW

‘nrqwc..._~

December 16, 1971

Arthur J. neikman,
15 Muir Avenue

M.D.

Mill Valley, Calif.
Dear Dr. Deikman,

with some
on Bimodal Consciousness
because you focussed on EEG evidence for

I read your report

interest, particularly

the concepts. The references to the EEG patterns associated
with the two modes of consciousness were illuminating. When the LSD
phenomenon was discussed, however, the EEG data was presented
ambiguously. The EEG effects during the EEG state are well defined,
an
exhibiting a shift of the mean frequency to a higher frequency,
of
(periods
with
seconds
'drop-outs'
increase in the number of
and delta activity.
flattening of EEG activity), and a decrease in thetamode
would be in
action
the
would
that
expect
Using your model, one
mode.
of
the
receptive
force, but the description is that
some of

is the state of delirium. In this
patterns are those of increased fast
state, the characteristic and
theta activity, and a decreased
frequencies, increased delta
The
subject is active, restless, and
responsivity to eye Opening.
outwardly, in the action mode; but the mental state is so severely
dissociated that it would be best to identify the state with the
Another problem for me,
EEG

receptive

mode. I think.

Finally, you will be interested in the recent data presented
by Itil and Ulett on the problem of EEG changes in hypnosis, and the
ingestion
reports of the EEG changes with acute cannabis inhalation and
and
decreases
which show increases in the alpha percent time,anplitudes,
in fast frequency.
Perhaps, in a later presentation, these data
integrated into the concept.

may

be

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

P.S.

My

best to

Dave Metcalf when

next you write.

�</text>
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                    <text>December 16, 1971
Dr. S. J. Mule
80 Hansen Place
Brooklyn, New York

11217

Dear Sol,

Enclosed

is

my

reiprt, EEG
Henry Brill

ETTEOts of’Drugs of’Dependbnoe,

and yourself. I regret the extra
volume edited by
delay but I hope the data presented justifies the qeiting. I would
be pleased to have your comments and suggestions for modifications,
should these prove useful to the overall design of the volume.

for the

My

best wishes for the volune's success,

happy and healthy

New

Year.

and

for a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 17, 1971
APHA

1015 18 St NW
Washington, D.C.

20036

Gentlemen:

I

am

interested in the following W.H.0. publications:
# 19

WHO

ExpertiCommittee on Drug Dependnece,

WHO

Special report on Cannabis, dated October or November,

1971

I would be grateful if you would quote the price for
these issues, and others related to drug abuse or cannabis.
Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 17, 1971

Professor Ian Oswald

Department Psychiatrist

University of Edinburgh
Royal Edinburgh Hospital
Edinburgh Ed lU~5
Great britain

HF

Dear Ian:

It was good to hear your report in Mexico City, and on my
nad
the occasion to re~read your report on fenfluramine
I
return,
and imipramine. As I understand your thesis, the abuse potential
is “blocked” by initial unpleasantness, or unpleasantness during
withdrlwal. This suggestion is descriptive enough, and is probably
accurate. Some years ago, we attempted a sudden withdrawal from
imipramine and found our subject to develop “withdrawal“ symptoms
(Withdrawal Symptoms Following Discontinuation of Imipramine Therapy, American

J. Psychiat.,

118:

549~550, 1961).

it

not true that ”dependence” develops to all drugs, given chronically? We have observed, and others
reported, withdrawal effects for phenotniazines and antihistamines,
and I would expect careful studies to show withdrawal to other drugs.
Using your model,

My

is

YOur suggestions are provocative, as was your presentation.
best wishes for a successful and nealthy 1972.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

Ming

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                    <text>Docember 17, 1971

Dr. Stanley Yolleo
Chairman and Professor

Department of Psychiatry
Stony Brook
Stony Brook, new York
SUNY

—

Dear Stan;
who

writing at the request of Joseph S.
is applying for appointment to the Department.
I

am

A.

Miller,

H.D.

Joe was the Hedical Director during my years at Hillsido
Hospital. He was a fine clinician and his conferences were well run.
he was most supportive of my research efforts. encouraging the Board
of Directors, and the Research Committee to approve the projects.
havo only seen him on fan occasiono since we both left
Hillside, so am less acquainted with the work of the past decade.
I am pleased to recommend him for a clinical appointment, knowing
it would be interesting to work with him.

I

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Whig

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                    <text>December 18, 1971

Society for Neuroscience

Bethesda,

Md.

Dear Mrs. Wilson,

I had heard of the first meeting of the Society for
Neuroscience, but was unable to attend. Since then, I have been
told that the next meeting is scheduled to peecede the American
EEG Society meetings in Houston.

interested in any information that may be
available regarding this meeting and membership in the Society.
I

am

Many

thanks.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>December 20, 1971

Dr. Honiqua Brande

Division Narcotics and Drug Abuse
National Institute of Mental Health

Fisharl

Lana
20852
Maryland
Rnckvillc,

5600

Dear Moniquo:

I as writing to yoqucst 200 grams nlnijuanc placebo
for our ongoing studio: of cannabis (In 18172) and our contract

or: expanding our sample in both populations
without altering the study protocol.
(62—70—98).

We

Enclosed

is

an opproptiato tequeat form.

Sinccrcly yours,
Max

Pink, H.D.

Praia-cor of Psychiatry

HP:13
Enc.

�</text>
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                    <text>December 21, 1971
Dear Dr.

Kosterlitz,
In response to your questions regarding

my

report to the

Aberdeen symposium, I am pleased to submit the following:

1. International Conference on Drug Abuse: Published by the
University of Michigan Press. Page numbers are not available.

2. Wikler: pages 85—102.
3. Resnick et a1.: is to appear in Comprehensive Psychiatry,
in the issue of November—December 1971, which should be mailed to
subscribers in January.
The second report was not accepted for publication, and should
be reported as 'unpublished observations'.

4. Page 8, paragraph 2, line 4: reference should be 1968

for Fink, not
1972.

my

1969.

best wishes for

a happy holiday season and a healthy

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>December 21, 1971

Mr. Walter Essman Ph.D.

Queens College
Remson Hall
Room 14

Flushing,

New

York

Dear Walt:

Enclosed

past quarter.

I

am

is our check for consultation during the
sorry the check was delayed, - the next

should be more prompt.
My

best for a happy 1972.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                    <text>December 22, 1971

Mr. John E.

Director

Ingersoll

United States Department of Justice
bureau of Narcotics &amp; Dangerous Drugs
Nashington, D.C. 20537
Dear Mr.

Ingersoll:

and find

have examined our summary records of methadone use,
that our clinic has diapensed the following amounts:
We

(1971)

152.8 gr 31113
169.1
155.8
142.3

July

August
September

g

October

1

Attached is a tabuiation of the number of applicants
for treatment to our clinic during the same period.

I trust these data are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hing
Enc.

�</text>
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                    <text>December 22, 1971

Dr. Paul H. Blachly
Professor of Psychiatry
University of Oregon Medical School
3181 S.W. Sam Jackson Park Road

Portland, Oregon 97201
Dear Paul;

again, I find your questions thought—provoking and most
relevant to public issues. I accept your premise that ”those who are
physically dependent or have been so in the past” should be admitted to
methadone programs ~ and our program is limited to those males with at
least a Zwyear history and one confirmed treatment failure. In answer
to your questions:
Once

(1)

We

(2)

I

(3)

We

do

not use naloxone to screen routinely.

know of no program

that does.

do not use naloxone to screen, for we admit all patients
to the ward, observe for withdrawal symptoms, and then detoxify with methadone if symptoms are observed.

to run a large methadone program, I would use naloxone
give naloxone for test purposes auout 4m7 days post—withdrawal
(0.8 mg IV) 24 hours (or more) before we give heroin challenges. At various times, 3-6 days after the last does of methadone, our patients have
had chills, piloerection, irritability, and insomnia ~ sufficient for the
staff not to wish to do a naloxone challenge routinely.

tests.

Wereel

We

(4) About prisoners, your suggestion is interesting. In nor~
subjects, naloxone has no effect on behavior, pupils, heart rate, or
EEG. In the recent post~addict, symptoms are precipitated.
I do not know
what to expect in an addict, ”clean” for some weeks or months, although I
would anticipate he would be like our normals. Surely, a man claiming to
mal

be dependent - and using opiates within
easily by a naloxone test.

3—6

days

-

would be

identified

�(5)

The suggestion about naloxone's

availability to police and
objection would be the rare sadist who would enjoy the discomfort of precipitated abstinence - but this
is a miniscule risk compared to the possible saving in overdose deaths.
I would anticipate a coma from non~opiate cause would have no adverse consequences from the naloxone.

ambulance

drivers is brilliant.

On two

The only

occasions, in patients receiving

100 mg methadone

daily,

our heroin challenges (50, 75 mg) elicited euphoria, respiratory slowing,
and miosis
evidence of insufficient blockade (cross-tolerance). We gave
1 mg naloxone IV, and in each case, precipitated a severe abstinence
syndrome, unresponsive to additional heroin, methadone, and chlorpromazine,
and being relieved only by time (3-6 hours).
—

Note also, that naloxone IV is usually effective for
only and in overdoses, must be repeated frequently.

2—3

hours

I would support the suggestion that naloxone be freely available
to ambulances, police, physicians', and pharmacies; would not object to
an over—tne—counter availability; and would encourage studies of naloxone
in prison (or hospital) units as a test for eligibility for methadone maintenance.

Incidentally, our acetylmethadol study is completed and it coninitial optimism in 1969. It will appear in JAMA a copy is
enclosed for your interest. Also, Eur first trials with naloxone pamoate
firms your

—

began December 16.

My thanks for the good wishes
about these provocative questions.

—

and

for the opportunity to think

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                    <text>December 23, 1971

Julian J. Lasky, Ph.D.
Executive Secretary
Department of Health, Education, &amp; Welfare
Health Services &amp; Mental Health Administration
National Institute of Mental Health
Mr.

Fishers Lane
Rochville, Maryland 20852
5600

RE:

MH18490—03

- Kurland

Dear Jack:

It

was kind of you to give me an Opportunity to see the menswand thus get a follow—up of the progress on this study. There
has been much effort eXpended in planning and equipping the EEG analytic

al request

portions of the study; the promised participation of an electroencephalographer. (Dr. Bohm) is no longer listed in the renewal or the progress
report; and 16 patients have had records analyzed on 3 or 4 occasions
during the ECT process. The principal focus seems to be on the EEG chang—
es induced by ECT and this is reflected in the large supplementary request of $36,000 for specialized EEG equipment.
A. Two observations have stimulated these workers. One is
the increase in podt—seizure alpha activity is related to a better clin—
ical evaluation, and increased theta/delta activity with lesser degrees
of improvement. This observation is reported as “contrary“ to that of
others. But, the study is not a replication, and many factors that influence the EEG expression are disregarded.

l.

The EEG

is recorded in the ten minutes before the

ECT

treat—

is given, presumably in the treatment room. This is a time when
anxiety may be intense and which may alter the EEG. Prior workers did
not use this method, probably because of its lack of stability. (Is it
ment

—

�ht. Julian

J.

Lasky, Ph.D.

December 23, 1971

not also likely that many of the patients will have received some anxiolytic therapy before the treatment
perhaps not for the psychotic
depressives, but surely for those rated as depressive neurotics?)
——

2.

any measure of
ing the amount

In the

EEG

evaluation, a difference score is used, without
The sample size is 10 minutes, and considerbe artefact filled, it would be a surprise if

variability.
that

must

the pre~sample, on which the results are highly dependent, is a reliable
estimate. (One should expect an awareness of the variablility of the
EEG and estimates of variance to be included in the
analyses).

3. The post—ECT assessment is at 43 hours. Rﬂilizing that
there is a decay in the amount of slow waves, and that this is most rapid in the early treatments, the authors now suggest estimates continuously
during and after the seizure for one hour; and again at 24 hours. Are
they implying that this pilot work was wasted? Would it not have been
useful to examine a few patients at various times and present this data
for a new study?
4. The records were evaluated for normality. By whom? With
what standards? One of the main reasons for the emphasis in the 1950's
on quantitative measures for EEG evaluation was a difficulty to achieve
agreement as to normality and abnormality among sophisticated EEG'ers.
The authors have more than adequate equipment to provide preetreatmeut
estimates of the amount of various frequencies, the amount of variability
in amplitudes, egg, « and to use statistical techniques to allow for the
relationship between these measures and change with ECT or with clinical
evaluations. But they eschew these techniques for an earlier technique,
which I would consider less reliable.
B. The second focus is the isoelectric period after the sei—
zure. This important observation follows the reports of Paul Blachly.
The observation here is contrary to those reported by Blachly, and inde—
pendently observed by my associates. Could it be that some of the isoelectricity that is measured is an artefact of the blockade of the amplifiers? This possibility is not mentioned. If the observation is valid,
what possible explanations do they have, and how do they propose to ex-

amine

it

further?

Perhaps the biggest disappointment is in the behavioral
In any correlation, the highly sophisticated analyses of
one variable (EEG) ought to be matched by equally detailed and time~re~
lated behavioral measures.
C.

observations.

1. There is one clinical psychiatrist assigned to the project,
so his observations must stand alone. He uses standard, gross measures
of behavior and the results are couched in the grossest estimate of 'im~
provement'. Improvement in what? Mood? Affect? Sleep? What of the
contamination of memory loss to the overall assessment?

�Hr.

Julian J. Lasky,

condition,
few.

December 23, 1971

Ph.D.

The authors use a fixed number of treatments. Under this
some patients may receive too many treatments and some too

2,

It is probable that psychotic depressives, the older patients, will

reapond to the extra treatments with memory loss. Hence, they hay be
evaluated poorly if memory is an integral part of the improvement evaluation. These patients may also show more slowing, for this correlation
increased EEG slowing and decay in memory function is well established.

~

3. Using their ratings for behavior, and assigning a value
of 2—3 eps from the graphs, we find the following:
amount
to the
Rating

LE;

1

7

23

l2

4
5

2
3

Mean

"delta"

5.7
2.0
3.0
7.5
7.4

I do not find their tentative conclusion, that delta increase
is associated with lack of improvement to be well grounded.
of the

Also, the behavioral measures are presented without making use
today.

statistical techniques available

is disappointing. xot uecause the authors have
presented little data, for they have made a good effort to get started
on an interesting problem. They have fulfilled some of the goals prom~
ised. But, the report shows a lacs of involvement by clinical psychie
This review

trists

with sophistication and hnowledge of the issue involved. The rem
newal focuses on gadgets ~ $36,000 of equipment for engineers, and no
funds for the researcners. Replacing some of the clinical funds and reducing the equipment would do little to improve the project, for it is

clear that the important investigators are beipcl and brown. If one had
much money, perhaps the $16,000 for each of 2 years may serve to keep
the project going at its present level. The electroencephalographic portions are also weak, and this may reflect the lace of someone with per~
sonal experience or involvement with this instrument (the promised ap~
pointment of a neurologistnelectroencephagrapher did not materialize).
I regret that I

cation. In

my

am

less than enthusiastic about this appli~
was optimistic that the problem may ex-

earlier review, I

cite the staff to a productive involvement ~ but this has not occurred,
and I am not sanguine that another two years would add much.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

MF:ig

�</text>
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                    <text>December 27, 1971

Prof. Dr. H. M. van Praag
Div. Biological Psychiatry
Croningen, Holland

Dear Prof. van Praag,

lick forward to your visit to our laboratories on Friday,
I would like for you to meet with some of my associates,
discuss
to
your research interests, paricularly your experience with
the probenécid test. The meeting will be informal, and we are
equipped for the presentation of slides, should these be useful to
your presentation.
We

January 14.

If suitable to your schedule,

and the formal session can begin

at

we
2

should meet

p.m.

at 1:30 p.m.,

administration offices and my laboratory are at 5 East 102
Street, on the corner of Fifth Avenue. It may be best for you to call
my office the day before or the morning of the 14th: (212) 369—7900 x255,
or my home (516) 466 5444 the evening before.
The

useful.

I will be pleased to
My

best wishes for a

forward with

make

hotel arrangements, should this be

happy and successful 1972-— and

interest to your visit.

I look

Sincerely yours,
Max

link,

M.D.

Professor of Psychiatry

�</text>
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                    <text>December 28, 1971

Dr. Turan

Itil

Missouri Institute of Psychiatry
5&amp;00

Arsenal Street

3t. Louis, Missouri

63139

Dear Turan:

received the tape from Istanbul, and found it comWe analyzed your “records” and
the range of values looks much like-tho EEG playback.
We

patible with our tape system.

Our difficulty is in identifying the “record” on the
tape. For example, our firtt EEG on playback looks like netthcr
of the two playbacks you sent. We have more ZO-aecond epochs
than your sample; the artifacts do not match, etc.
We

make

if

will

be pleased to analyze

available paper or card outputs, or

the data are complete.

similar tapes,
some

and can

statistical analyses

I an enclosing a summary outline of instruments we
used in another atuiy. This will give you one way of identifying
tho racord on tape, so no can find the correct record for each
subject.

My

beat for 1972.
Sinccrcly yours,
ﬂax Pink, H.D.

Professor of Psychiatry
33:13
But.

�</text>
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                    <text>December 28, 1971

Dr. Craig D.

Eurrell

Vice-President, Medical Affairs
Sandor Pharmaceuticals
Hanover, New Jersey 07936
Door Craig:

It is

not clear what additional information would
be useful, to the study was incomplete. But, I am pleased to
enclose xerox cepies of the summaries and behavorial ratings
on the subjects in this study in our files.
My

best wishes for 1972.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Hr:ig
lhc.

�</text>
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                    <text>Dace-bar 28, 1971

Dr. ﬂush K. ﬁuaaay, M.D.

Jﬁwﬁi

535 N. Dcarborn

Chicago,

_

Illinoia

60610
RE:

REF:- HS #3163
7
:\.

Dear Dr. ﬁuaaay:
have reviewed the data in our study of ”i-AlphaAcetylmctoadol in Maintenance Treatment of Opiate Dependence"
and find that some of the interesting relationships can be pre—
sented in tabular form. We have made up such a table, and it
We

is attacﬁca.

seemed somewhat lengthy, we indicate a section
tables.
that can be separated, and toe data presented in two abide
by
As this is a matter of style and appearance, we will
As

it

your decision.

for your kind consideration. I trust that
high price of the base material for
excessively
the raputed
soon be roduced, so that more ex—
will
£-alpha~acotylmethadol
tanaiva clinical tests can ha dona. Publication of thisandexper—
in—
ionco may serve to stimulate a more rapid governmental
Thank you

duatrial raaponao.

Sincerely yours,

as: link, at».

Profaaaor of Psychiatry

anig
inc.

|

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“£45,931

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t
3

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1/5

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1/3

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16.9%

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for Barb1Cutate

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�</text>
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,

Why-”W—WVW"my-n.

:I‘w'w

December 29, 1971

William Bunney, M.D.

National Institute of Mental Health
Rockville, Maryland
Dear Dr. Bunney,

In the course of our studies of cannabis. I became
acquainted with Dr. Rapael Mechoulam of the Hebrew University. Dr.
Freedman was able to interest him in the problem of the development
of a long acting narcotic antagonist. A copy of a recent letter from
him is enclosed for your information.
Should there be a list of potential laboratories capable
of studying the problem of a long acting antagonist, you may wish
to add his name, and consider his participation in any collaborative

program.

My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>November 1, 1971

nun

wu~

Vw‘....a....-.~.m—n

5.....-"

Dr. Jean Paul Smith

Division of Narcotics &amp; Drug Abuse
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland

mvvuvw'fv-

Dear Dr. Smith,
aw?

I am enclosing preprints of a number of our reports
regarding naloxone and cyclazocine, and the latest report on the
comparison of methadone and Z-alpha-acetylmethadol. The latter
report is being submitted to the JANA.

‘m

A

«Izslv'll'mn‘

Separately, Dr. Alfred Freedman has submitted a grant
application entitled Novel Narcotic Antagonists in Mhn for the
consideration of the appropriate committees of NINE. Included
that proposal is a sum of money for the subcontract to do the in
animal toxicity studies necessary for an IND for the antagonist,
MFSOSO. Any assistance you can give to that
application will
allow that agudy to progress rapidly.
Again, I regret missing the meeting on narcotic antagonists,
trust that we will be able to contribute our resources to this
interesting program.

and

Sincerely yours,
Max

gm.

;
‘77

~1‘lw‘v‘ww—

mf/
.

,‘ﬁkww,,“w.-wnr—.V

r6"

vaI-

2w:

wwwrw‘

“trap-535w.

.
r':

-.

Fink, M.D.

Professor of Psychiatry

4

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                  <elementText elementTextId="103587">
                    <text>A..,..

.A

....

.....

W...“

V.

—,

vmw.‘mwvmﬂmm
,

"mm-— W w w
.

&lt;

,,

- r:

memww’ww W n. m
..

r

,

. ....,_,

“Wm W’s—nab

Dr. Werner P. Xoella

Ciba-Geigy

Basle, Switzerland
Dear Werner,

written
Regretfully, there are no copies of the report
EEG
methods
analysis.
of
by Don Shapiro and myself on the quantitative
That report was written in 1.966 and described some of the basic
studies upon which we based our decisions to use period analysis,
epoch size, sanpling rates, filters, etc. Since then, we have

altered our programs considerable, based on our subsequent experiences,
and that issue is now outdated.
we have often spoken of a need for a revision of that
volume, but have not got to do anything about

it.

a number of occasions, we have been asked by some
laboratories about our pregrams, and in each instance we have suggestedand
that they would do best to send someone from their unit to our center,
we can discuss your needs and aims, and provide the backgroundin formation
you wish, either Don Shapiro
for a proper EEG analytic program. Or,
or I can visit your laboratories in Basel, and work with you to develop
the programs to your specifications.
On

if

Separately, I am sending you some of our recent preprints
which will describe the results of our present programs.
Incidentally. Dr. Jiri Roubicek, who was a student in
Basel with Sandos,
my laboratory for more than a year, is now resident in
the
qucmtification aspects,
and while he does not have the experience for
marvelous
he
is
a
person.
meeting
him
enjoy
for
may
you
My

best regards .

sum

-

w"

w

r

"lrrw-qu

wry-wan.

mpwvam—uw

”p.”

a.

November 1, 1971

w—u..«,.~w....—.

A—

.

Sincerely yours,
Mas:

Fink,

M.D.

Professor of Psychiatry

W

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                    <text>November 2, l97l

Dr. Michael Beaubrun

Professor

Chairman,

&amp;

DeparTmenT of Psych iaTry
Univers iTy of The Wesi indies

KingsTon, Jamaica

Dear Dr. Beaubrun,

for

AfT er

The sTudy of

considethle delay

chronic cannabis use in

and

considsraTion

The

eraica

applicaTion

has been forwarded To
have hel d prior consuiTaTions wiTh various of The officers
WashingTon
in “ashinnTon, and have been Told ThaT This s.udy, wiTh The one in Greece,
has a high priorlTy, buT ThaT funds for The l97l-l972 fiscal year for
These conTracTs hose noT yeT been approved. Approval is excecTed This
l

monTh, and These

applicaTions are in hand in Time.

have also requesTed The leTTor of inTaresT in such
lnsTiTuTem and This is under consideraTion.

l

sTudies by

The

lT was mos T useful To have Mr. Beecher, and l TrusT he
do noT know wheTher some funds are necessary from
enjoyed his sTay.
our sTudy propram, huT if There are some ThaT may be useful, please

i

wriTe To me.

l
have asked Dr. Dornbush To wriTe To Mr. Chevannes To
The
him
TimeTable and To enquire as To his cooperaTion, since
of
apprise
he indicaTed ThaT There may be a change in his sTaTus aTbThe
of The

.year.
A

duplicaTe copy of The proposal is enclosed

his

for Professor

Ward. As he may have Told you, i did discus
budgeT wiTh him and
*The budgeT as sulmiTTed includes his reques Ts (modified) and your own.
i
would urge boTh of you To review The deTails, and assuming our NlMH
will supporT The sTudy, will ask you To confirm ThaT The summary includes
The lTems necessary.

have also senT a copy of The proposal To Dr. Henry
The U.S. Marijuana &amp; Drug Abuse Commission. I undersTand he
be vlsiTing you nexT week. i have asked him To presenT The proposal
I

Brill of

will
To his commission for supporT, for iT
NaTlonal lnsTlTuTe of MenTal HealTh.

may

inTeresT

Should he

Them

as

much

as our

raise quesTions regarding

�h

Dr. Michael

Beaubrun..........November 2, l97l

...........................2

if wouid be helpful for you To be as candid as possible.
was
Brill
responsible for esieblishinq our siudy in Afhens, and has
mainfained a deep inferesf in iho possible consequences of chronic cannabis
This proposal,

Dr.

use.

year,

faborable response before The end of iho
proceeding wiih orders for fhe addiiional equipmen+~on.a
Anficipaiing

I

am

a

contingency basis; and have scheduled VisiTs To Jamaica immediafely
afier The New Year. if should be possible for one of fhose funding

agencies

+0

indicaie fheir posifion

by

early

December.

Meanwhile, should any daia from ihe populaflon survey
would be helpful To provide fhese in supporf of This
i would
appreciaie a copy as soon as possible.

available, if
applicafion, and
be

i

in Mexico Cify
_

bes? regards +0

shall be aiiending fhe World Congeess of Psychiatry
+he end of ihe monlh, and shall look for you. My
your wife.

ai

Sincerely yours,
Fink, M.D.
Exocufive Direcior

Max

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                    <text>.. --_,.... wen—&lt;wmw‘v.wem

Wﬂwmn

November 2,

Dr.

W.

1.9

71

C. Bunney

Actind Director

Div. Narcotics &amp; Drug Abuse
National Institute of Mental Health
Rockville, Maryland 20852
Dear Bi f,

in Marseille in September at a meeting called

While

by the President of the University on the subject of cannabis research,
was impressed that they were doing excellent work with materials of
unknown potency. The dosages administered exceeded in THC content those
ordinarily given in the 0.5., and urged Dr. Gastaut to request some

I

I

materials from the National Institute of Mental Health, so that his
findings could be compared to those of our own and of other laboratories
in the 0.8.
A

copy

of his letter and

are enclosed for your information.
be

my

covering

letter to

Monique

Any assistance you can give these scientists should
in
repaid
fine, comparable data.
Many

thanks .

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

cc: Monique Brande, M.D.
Henri Gastaut, M.D.

�</text>
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"'wmwm

WWW—"mm: w—wr—w:

av

November 3, 1971

Dr. Monique Brouds
Div. Narcotics and Drug Abuse

National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland 20852
Dear Monique,

At recent meetings on the subject of cannabis
research in Marseille, I was impressed with the variety and extent
of research into hashish (kif) and cannabis by Professor Henri
Gastaut and his colleagues. They have excellent facilities for
the evaluation of the central and systemic effects of various
cannabis derivatives, and were assessing compounds of high THC
activity, in dosages that were higher than those conventionally used
in the United States.

comparability between his findings and those
investigators, I suggested that he obtain some NIMII supplies
of
and use these in parallel with his own materials, providing in his
publications, some assessment of the changes induced by his materials
and the U.S. materials.
To provide

U.S.

is

a letter requesting some U. S. material
would
fbom Professor Gastaut. I
urge your office to make such supplies
he
may request available for him and his associates. Their findings
as
be
will
complementary to our own, both in New York and in Athens, and
be
should
of special interest to our scientists and the Marijuam
Conmrission.
Enclosed

Many

thanks

for your assistance.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

cc:

H.
V.

Gastaut,
C.

14.0.
Huntley, 24.0.

.————m m ”may...“
w

m

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November 2,

1.9 71

Prof. Henri Gastaut
Hopital de la Timone
Bd Jean—Moulin

13- Marseille, France

Dear Prof. Gas taut,

In response to your letter regarding supplies of
and cannabis for your research programs, I called :our National
Institute of Mental Health center for distribution of thesupplies,
and introduced your request. My letter to Dr. Monique Broude, the
THC

scientist responsible for the distribution of supplies, will serve

to begin the orderly process of making the materials you request available.
will write to you shortly to indicate the type and quality of the
material on hand, and ask for some additional information that her
Comittee may request.
She

usual processing time of requests has been 2 months,
fail to obtain some assurances within that time, please
again.

and should you

write to

me

The

My

n

best regards .
Sincerely yours,

J“wmmt'_wumr.wmwmwx

Max

Fink,

M. D.

Professor of Psychiatry

cc: Dr. Monique Broude
Dr.

W. C.

Bunney

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awn"

-

'

,...-....

Dr. Michael Beaubrun

Professor

November 2, l97l

Chairman,
Department of Psychiatry
University of the West indies
Kingston, Jamaica
&amp;

Dear Dr. Beaubrun,

After considerable delay and consideration, the application
for the study of chronic cannabis use in Jamaica has been forwarded to
Washington. i have held prior consultations with various of the officers
in Washington, and have been told that this study, with the one in Greece,
has a high priority, but that funds for the l97l~i972 fiscal year for
these contracts haze not yet been approved. Approval is expected this
month, and these applications are in hand in time.

studies

have also requested the letter of interest
lnstitutem and this is under consideration.

i

by the

in such

It was most useful to have Mr. Beecher, and i trust he
do not know whether some funds are necessary from
enjoyed his stay.
our study program, but if there are some that may be useful, please
I

write to

me.

have asked Dr. Dornbush to write to Mr. Chevannes to
apprise him of the timetable and to enquire as to his cooperation, since
he indicated that there may be a change in his status atbthe end of the
year.
i

duplicate copy of the proposal is enclosed for Professor
told you, i did discuss his budget with him and
the budget as submitted includes his requests (modified) and your own.
i would
urge both of you to review the details, and assuming our NIMH
will support the study, will ask you to confirm that the summary includes
the items necessary.
A

Ward. As he may have

have also sent a copy of the proposal to Dr. Henry
U.S. Marijuana &amp; Drug Abuse Commission. I understand he
will be visiting you next week. i have asked him to present the prOposai
to his commission for support, for it may interest them as much as our
National Institute of Mental Health. Should he raise questions regarding
I

Brill of the

.W. .srw.r,_.7,m_,_

�z
‘

_-W——w——-——w—e—

Dr. Michael

'r-‘u'l-Iw

,

T—wv'vr'IW-‘m _——W_.._..._
.

Beaubrun..........November 2, l97l

wuss-aura:

m m.

....__w——.—..&lt;~v-_—-..e«ww

...........................2

w-«w—

this proposal, it would be helpful for you to be as candid as possible.
Brill was responsible for establishing our study in Athens, and has

Dr.

maintained a deep

use.

year,

i

am

interest

in the possible consequences of chronic cannabis

Anticipating a faborable response before the end of the
proceeding with orders for the additional equipment on a

contingency basis; and have scheduled visits to Jamaica immediately
after the New Year. it should be possible for one of these funding

agencies to indicate their position

by

early

December.

Meanwhile, should any data from the population survey
available, it would be helpful to provide these in support of this
application, and I would appreciate a copy as soon as possible.
be

shall be attending the World Congeess of Psychiatry
at the end of the month, and shall look for you. My
best regards to your wife.
i

in Mexico City

Sincerely yours,
Fink, M.0.
Executive Director

Max

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                    <text>November 2, l97l

E

Dr. Robert Petersen
Natlonal lnstltute of Mental Health

Rockvllle, Maryland

l

Dear Bob,
am pleased to enclose our appllcatlon for an
extension of the studles of chronlc cannabis users to a populatlon
ln Jamalca. The study, Physiological Effects of'Chronio cannabis use
in Male Jamaicans, ls planned to progress ln parallel wlth the
Greek study.
I

A copy of this proposal has been sent to Mr. R. J. Gradwell
of the Contracts Management Branch and to Dr. Bunney.
My thanks for your recommendatlon, and for the
opportunlty to conslder thls lnterestlng study.

Slncerely yours,
Flnk, M.D.
Executlve Dlrector

Max

"HI-WW

‘

.

,
.
.

'5-H’

�</text>
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                    <text>-7.

._...._. .0...“— m—e—mw..m—m-rn

"W. W- -mw

“wmmm—“iwvaw. _.,__...___._A...,.._...v.“

-mm -mmv..._....w

. "-7 r.

71m- (WW...

-—.. ‘7

- r-

.. W

.w—.—...._

uW~—'.wVw—.——-—w.—.nw-

November 2, l97|

i

l

Dr. Wllllam Bunney, Dlrecfor

Dlvlslon of Narcoflcs

&amp;

Drug Abuse

Naflonal Ins+l+u+e of Mental Healfh

Rockvllle, Maryland
Dear Blf,

-——-rw

pleased To submlf an appllcaflon for fhe sfudy,
Physiological Effbots of’Chronia Cannabis use in Mhle Jamaicans, for
your conslderaflon. Thls appllcaflon complemenfs fhe s+udy of chronlc
cannabls use In Greece whlch Is now In progress, and for which an
I

s

am

exfended appllcaflon was submlfled last week.

have sen? a copy of fhls proposal to Mr. R. J. Gradwell
of The Confracfs Management Branch of the lnsflfufe, and fo Bob Pefersen.
I

My

Thanks for your cooperaflon and

lnleresf.

Sincerely yours,
Flnk, M.D.
Execuflve Dlrecfor

Max

_

,

,

_

V

n

.

W

‘

_........,

,

�</text>
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                    <text>_.._.

. ..
.

.

‘7‘ .

,. —“»~~_—-=..~—

v—www.

u...

ww—umw—n—W..

m_.m__ ,(w, "w_,,( ,

_

,

W

w.-.

__.

W‘

,_

7r. _

_

_

,

November 2, 1971

J. Gradmll
Chief, Contracts Management Section
National Institute of Mental Health

Mr. R.

Rockville, Maryland
Dear Mr. Gradwell,
HSM—42- 70—98,

In conjunction with the extension application for
I am enclosing an application for the study, "Physiological
"
Jamaicans
It is our belief that this study will

Effects of Chronic Cannabis

Use

in

Male

complement the
observations in Greece, and provide the “formation of interest to
the public today.

This proposal has been discussed with Drs. william
and
Robert
Petersen of the Division of Narcotics and Drug Abuse,
Bunney
and copies are being sent to them for their consideration.
Thank you

for your consideration.
Sincerely yours,
Max

Fink,

M. D.

Executive Director

�</text>
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                    <text>m

wno

....,

...

. _

”ﬁrm—n.

.

rum—w."

.w

my.

mm ..—«-m—..m—W.W_,.—. ..m-&lt;'V—4——wwr ‘v’wwwu-

.

.

.

“w"’

Dr. Henry

Brill

National Marijuana

&amp; Drug Abuse Comriseion
”JV.
Street,
Washington, 0.0. 20006

801- 19

Dear Henry,
During the past two months,

busy with the problem

my

associates and

I have been

of chronic cannabis use. Enclosed are a few

products of those labors:
a)

An

b)

A

c)

A

proposed extension

interim report of the

of

Greek study; and a

the study as submitted to NINE;

report

’Cannabis Psychoais', prepared

held recently in Amsterdam

draft of the

for meetings

proposal to extend our study of chronic cannabis use
I am not sanguine that NIMH will fund this study
(or the Greek extension), I am hopeful that both studies can be done
since the Greek study is so interesting, and the Jamaica study will
complement this data, providing an independent validation or contrast
to the findings.

to Jamaica. Vhile

Would it be possible for the Cosmission to support this
In
study
your forthcoming visit to Jamaica, you will have the opportunity
to appraise this application. Should it be helpful for me to join you
during that visit to discuss the proposal, it can be arranged.
?

During Dr.

Bossetti's recent visit to

it

that the

my

laboratory, the

Commission may find
useth to review the
available chronic cannabis use data, by inviting presentations from Dre.
m'ras, Stefanie, Beaubrzm, Vera Rubin, and our laboratory. We could then
describe our chronic studies in New York. (The data of our 21 day study
are almost analysed add the report should be ready by early December).

suggestion

my,”

~

,,..

November 3, 1971

'm"vr"

«v

n... ”wan—.7».

My

was made

I am most

best regards.

grateful for your support, and await your advice.

m"

.
v...

Sincerely yours,

7A...

.'

rung-v—w-rnx

Vs

r'wvnw‘

Mas:

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>November 3, 1971

Dr. Gerald L. Klernsn
Harvard Medical School
Hassachusetts General Hospital
2

Fruit Street

Boston, Massachusetts 02114
Dear Gerry:
membership
Award

w-

v.

.

.
v

,t

,
.

n....,....,.(.,.

m..."

for

For this work, he received the 1969 Clinical Research
of the Society of Biological Psychiatry.

During his residency, also, he carried out independent

verification of the lactate infusion test for anxiety neurosis,
firuing the

work of

Pitts

and McClure.

con~

Since returning from military service, he has established
a variety of independent studies at Metropolitan Hospital, in anxiety

and

in schisOphelits

I an pleased to

recommend him

for

membership.

Sincerely yours,
Max Pink, H.D.
Professor of Psychiatry

:

:71vr

Dr. Michael Alan Taylor
American Psychopathological Association.

As a resident physician, he use most industrious and
undertook independent research into the concomitants of post~partun
schizophrenia. Demonstrating that the sex of the offspring bore
a significant relation to illness in the nether, he subsequently
demonstrated that hormonal effects operated concurrently with the
staractic properties of drugs—- a conclusion derived from his data.

\,.,,.,‘v:..r.:.,,-.

awn...”

I an pleased to nominate

in the

83:13
Enc.

�</text>
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                    <text>=1—

mt‘wwsrﬂ

Hoveaber A, 1971

Dr. warren Glaser

Director

Out Patient Department (Medicine)
Kings County Hospital Canter
450 Clerkson Avenue
Brooklyn, New York 11203
Dear Dr. Glaser:

staff of the Division
of Biological Psychiatry of this department during the period of
July 5, 1967 to July 1, 1969. During this time she wen internist
in our Narcotic Addiction and Psychiatric Pharmacology Program.
Dr. Amelia 3. Banana was on the

When she began, her cxperinee with narcotic addicts
bed been limited but she was willing to assume responsibility for
their examination and nodical care. During the tine they were
given new drugs. she was dependable and did her work carefully.
Because she was Spanish speaking, she made a special contribution
to the care of a large segment of our patients.

She became so interested in clinical psychiatry
from
our program in order to become a psychiatric
resigned
She

is bright, enthusiastic

and

friendly.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

H3213

that she
resident.

�</text>
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                    <text>~.»-

"-—

A
w

v..." -.—_r-— n

ku: ...n gymnw~m.mm..,_.w_.

W~n my... ”mow-r. nrw—utmw m:--Wu .n “Amy—w w—‘~...m 4—.v—n‘rl—ww'",
»

,

. 7‘

~.~_‘-V~.....V.._......vv. _........ .._.._-..._~.‘_.,v.~,..w~,r.r.r...,..z .—.~—....__..._..

Hovonbar 4. 1971

Dr. Clyde Strickland
Merck, Sharpe 8 Doha.
West Point, Pennsylvania 19486
Dear Clydo:

w-

,.
«aw-w

“WWW

34.."

m

w"

-..

Enclosed is a report of our comparison of l—alphaw
acetylemothadol with methadone. We found 80 m3. methadol three
times a weak equivalent to 100 mg. methadone daily. While the
therapeutic saving is small, the saving in illicit methadone and
parsonnel costs can be large.

WquﬁV—Wﬂ"

7
~

,;-;wr-w"‘

melmvnmtw~mwz

My

thanks for your cooperation.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Max

Elsi;
Enc.

.‘r-—~..‘..

.

.

r

v...— _..

..

�</text>
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                    <text>Novonbor 4, 1971

Dr. Harold Moinola

NYS~NACC

1855 Broadway

Now

York,

New

York

Door Harold:

have just completed our conporison of methadone and
l-alpha~acaty1omothadol. The results show nothadol at 80 23., throo
tins: a wook, to ho equivalent to daily nothadono.
We

and

Condidoring the potential saving in diverted nothadono,
3 nor: extensive study ohould haw: a high

in personnel tins,

priority.
(we have

Additional copies for the Commissionor are oncloood.

sent the tort to
My

JAMA

for consideration).

best regards.
Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Mar

Hr:ig
Koo.

�</text>
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                  <elementText elementTextId="103573">
                    <text>”“1 “mu-mm,- W “M-.. w. Wm".

wwhn‘

“rpmqv

Wu...» vnv

W- ._,

_

..r

.2"

"w

w, «qr—m.-. T.“ .

..

7.,

_,

W... -.x.- u..._._.V..Hv.—.,.,._.v._._.w.m,

aﬂwu .;

--. .

W

mm

M

m

-

nyve-«m—wr'ww

r-r

November

Mr. Karl
CBS~TU

Ubell, Science Editor

5. West 52nd

New

York,

Dear

4, 1971

Stroot

New

York

Earl:

Enclosed is e report of our acetyleaothndol comparison
with nethadone. as submitted to the JAMA. The study provides good
evidence that methadol three times A week is equivalent to daily
nethndono. While there is no therapeutic advantage, there is a
potential saving in divorced nothedono.
and we are

Our

studies of cannabis in Greece are progressing well.

starting parellol studios in Joneicn.

for tho antagonist, Endo hes produced a long acting
panoete ﬂora of naloxone, to be tested early next your.
As

My

best regards.
Sincerely yourn,
Pink, H.D.
Professor of Psychiatry

Max

M3313

Inc.

.

..

--.-r~4

.

rm“

�</text>
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                  <elementText elementTextId="103572">
                    <text>mu'mmv"'ﬁl‘

n-u

"Yr-1r"

-&lt;

«nnm-

“w..."—

v...

T

'nr-ng’wv-

w,—

”I“;

.Z'NWJW'I

z-rwvjv'

s-‘fa‘wwﬁw-"r

ll»

Hovenber 4, 1971

Dr. Lester
Editor

King

Jﬂml

535 North Dearborn Street
Chicago, Illinois 60610
Dear

Sir:

We are pleased to submit the report, "1~Alpha~Acetylemethadol
in Haintenence Treatment of Opiate Dependence“ for your consideration
for the Journal.

This etudy deacribee similar clinical reeulte for l-alphaacetylenethedol given three tines a week to daily methadone. Should
this prove generally applicable, the saving in illicit methadone and
its coneequencee can be great.
Thank you

for your consideration.
Sincerely yours,
Fink, H.D.
Professor of Psychiatry

Hex

erig
Enc
e

�</text>
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                    <text>November 4, 1971

Dr. Louis Bozzetti
U.S. Commissioner Marijuana
801-19

Street

N.W.

&amp;

Narcotic Abuse

Washington, D.C. 20006
Dear Lou:
on the

It

was nice having you

visit

and

I

hope a

effects of chronic marijuana can be arranged.

presentation

Separately I have sent Dr. Henry Brill a proposal to undertake a study of chronic cannabis users in Jamaica, as well as a copy
of our Greek study interim report.

I am writing about another question. In working with
the Greeks, I was told about a prior study of hashish by Dr. M. G.
Stringaris, published in German. After much travail, I obtained a
copy of the original and asked a translator to make the text comprehensible in English. She has completed the first section (24
pages). I am enclosing a copy of her translation.
Is it within the Commissioner's activities to use such
a text and data, and can the Commissioner support the translation?
The text is 66 pages with an additional 33 pages of case histories.
My

best regards.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig

inc.

�</text>
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                    <text>November

Mr.

4, 1971

Earl Ubell, Science Editor

CBS~TU

ﬂ.West 52nd Street
York, New York

New

Dear

Earl:

Enclosed is a report of our acetylemethaﬁol comparison
with lethadone, as submitted to the JAMA. The study provides good
evidence that methadol three times a week is equivalent to daily
methadone. While there is no therapeutic advantage, there is a
potential saving in diverted methadone.
and we are

studies of cannabis in Greece are progressing well,
starting parallel studies in Jamaica.

Our
As

for the antagonist, Endo has produced a long acting
tested early next year.

my

best regards.

panoate form of naloxone, to be

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

Ming
Ihc.

�</text>
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                    <text>November 4, 1971

Mr. Robert

Ubell

Plenum Publishing Corporation
227 West 17th Street
ﬁgs York, New York
Dear Bob:

In the course of our studies of heshish users in Greece,
across a monograph in German, "Die Easchischsucht" published
in 1939 by Dr. M. G. Stringaris. Not finding any translation, I
imposed on a friend to do the work, and I am taking the liberty of
enclosing the translation of the first chapter. The text is 66 pages
with 33 additional pages of case material.

I

came

Dr. Stringaris
Do

is alive in

Athens.

you think there is a market for a
do you wish to handle this?

this text? If yes,

translation of

I appreciate your advice.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF:ig

Ens.

�</text>
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5, 1971

Grass Inetrunents Conpeny

101 Old Colony Avenue

Quincy, Meeeachueette 02169
7.‘

harm—Iv

Dear

Site:

are sending to
for repair.

We
-.,,—.-.

,.r

you the Cress

amplifier,

MOD

7P511,

Thank you

for your assistance.
Very

truly yours,

Fink, M.D.
Professor of Psychiatry

Mex

3?

J. Volevke.

“ﬁlm."

Wm

#731P1,

During the recording (approximately 1 1/2 hours) the gain decreeeod
to elmoet zero.

”noun—rm"

-

Seriel

m/Jvug
Enc.

K.D.

�</text>
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                    <text>Hovember 5, 1971

William Tabor, 24.0.
A. E. Robins 00.
Richmond, Virginia

Dear

Bill,

for the

Enclosed are the completed
study, your number 1301.

AER-4118

It

was

My

best regards.

clinical data form

a pleasure to have the opportunity to

review this compound. Hazy thanks.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>nv—u—wn—wx.wn..—wmwv-u-—.mw--~»wumarr—“Wm‘v—I-w.«r.'-I4.m‘—W.ww~r‘iw.'&lt;-" #V'FI-E'P-“IIZ-n-u-m

".v.”

..

.. .W

MW“.-.

".7.

my"...

1..“ .7.

.._-_...,.._...,.\:r

..

Hovembet 8. 1971

Dr. Jon. Carrtnta~Acevodo
Kano, Clinical Pharmacology Section
Instituto Mexicano del Seguro Social
Division de Farmncologia
VJ

,.

Apartado postal 73~032
Mexico 73, D.P.

.-.-—wm-w

Dan: Jose:
.‘vf'!'AVV.‘

-m.-.

1972.

The

is meeting this your in Lao Vegas, January
hotel for the meeting is Caesar's Palace.

The ACE?

18~21,

wt

I havo already "used up” my one invitation; I would
suggest you do what so many others are doing ~ registering either
at Coolants Palace or a neighboring hotel (there are very many)
and attend the nesting as a visitor. So for, no one has ever been
proscribed from registering or attending.
As

o‘nar’wara-wrxm

rm.

3W

I plan to attend the W.C.P. at the
to toting you there.

and look forward
L'Wﬁrn‘u‘

My

and of tho month,

but wanes.

m~uwmr

Sine-rely yours,
:vwm

.W

Warren-74

Ir

w-w

'
'

nave;

Mu

-m‘,

M

ﬂak. ”and
m
Profcosor of Paychiotry

.rt

"qr.

mp

,

.

u...“ ,..

.

T,

�</text>
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November

v-

8, 1971

.mew'yq'ypwnwrm-v-w

Dr. ﬁichacl Sheard

Foi'w'y

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&lt;

Department of Psychiatry
Yale University School of Hedicilo
34 Park Street
New Haven, Connocticut 06508
Dear Mike:

wv

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a

w-nwmr

Juror-ww-

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To add to the EEG~lithium data, you could write to
Joyce Sucall, Professor of Psychiatry, University of Indiana
School of Medicine. 1315 West 10th Street, Indianapolis for

her report.

Summary

is oncloaed.

""rnl':.ra3-1Summwu

Sincerely yours,
-

Fink, M.D.
Professor of Pyychiatry

Max
new

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�</text>
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Wmmm—W

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r-vrrrw

November 8, l97l
TO:

Richard Abrams,
Rhea Dornbush

Jan Volevke

The various reporfs for +he ECT issue of lhe
Seminars in Paychiatry are in The hands of the publisher, and we
should receive galleys wlfhin 6 weeks. The issue is due to appear
in February.

publisher has indicafed Thai he will give each
of you a subscriplion, in grafifude for your cooperafion.
The

enclosing a copy of The idenfificaflon
sheaf, as submifled. if incorrecf, please advise.
l

am

l van? #0
express my personal thanks for your splendid
I
know the? l would nof have undertaken
and
enfhusiasm.
cooperation
I
no?
had
This efforl, if
fell lhaf you would do as well as you did.
i
The confribufion to ECT undersfandlng fhaf
make
hope fhe issue does

is so sorely needed.
My

Thanks.

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