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                    <text>Havember 22nd, 1972

Jerome Jaffe, M.D.,
B.A.O.D.A.P.,
White House,

washington, 9.0.
Dear

or

Jerry,
Perhaps you should know about

methadone

delivery.

this extension

sincerely,

Fink, M.D.
Professor of Psychiatry
Mb:

rim/15

Ens.

.
4-,“,

A,

.

-.-;n

‘-

-n~,-

'nmm"

vu.

,
-—.

-.-v

:v

awn:

“c:

aw

‘

v-avznu-w

M

«(Irrw/m

‘Vm‘vwwWWe-w'v-rrn'rr-w-

�</text>
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                <text>1972 </text>
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                    <text>Hovonber 22nd, 1972
Congressman Poul Rotors.

0.8. Congress,

Huntington. D.C.
Dear Mr. Rogers,
Binos our discussion more than a your ago, the goal of
mothsdone dolivory for our nation hss progroaoed with
grout rapidity. The Journals spook of 50.000 pstionts now in
trontmont in the notion. with treatmont (with mothsdons) without
delay available to every sddiat, so that orinos kill no longer

gensrsl

bu necessary.

Enclosed

is s flyor I received

physicians in the city.
When VB

lost spoke, I

from a mailing

oxynpsnod some optimism

nsrootic antagonists may provide

some

to

all

that the

assistance, and you

assured no that tho (than) forthcoming bill would provide funds
for tho effort. And indeed, the bill supportod research
specifically in tho narcotic antagonists.
Enoloood

is

our

latest retort. It suggests to no that
is more fossiblo than generally

success with cyclazocino

acknowledged.

I on writing to oxpress some dissppointmont with the
notionsl effort. The push to nothsdone has led (us was predicted)
to freely svsilsblo mothsdone, primary nothsdono addiction,
nothndone deaths, and a nothsdons illicit market. A small
impediment to this spread. tho suggested use of levomethndyl, in
faltering hocnnso tho F.D.A., K.I.M.H. and B.A.0.D.A.P., fearful

of changing the rulos sgsin (hsving done so for methadone) are
using sdminiatrstivo caution ("red tape") to delay studies in
man until animal studies can ho completed.
But most disooncorting is s continued bad press for
oynlnnocino; an Optimism about nsltroxone (EN1639) - s drug
as yet unawaildblo for cliniosl trial; and the ineasssnt push

to nothsdono.

�Congressman Paul Rogers

«2»

H0vombor 22nd, 1972

When wa last not,
of the laboratory ut Kev

you ﬂora oonoarned that the position
York Mbdioal College was partisan,
our opinions wore clouded by an unconscious donire to

and thnt
.sea "our" therapy tented. Ho nova united and watchnd the new
scans for more than a yunr. and regretfully. unbnrked on this

oaumunication.

or the

Perhaps the

on some

first

tins will

soon be appropriate for a review
bill or 1971. with a focus

year of the drug abuse
questions such as:

is the rate of

What

tho state of the

cases into methadone? What in
The number of primary methadone
to opiates?
new

illicitduemarket!

addictions. and death:

What, indoed, in tho

trials truly

Wt

antagonists!

status of levumothadyl and are the

being expedited?

is tha 3.1.14.3. "
And

SvoOoD-AtFO pmgrm for
in tho Congress satisfied with this program?
A; over,

«Iv-:mv‘mw-

pro:

Your: nincorely,

4‘

.A

mvrww’w-yrc-

nag-.m-

MR: Fink, M.D.
Protnasor of Psychiatry

mam-awn

MF/iJ
Eno.

cc. to senator Jacob Jovita
Rap.

Lester wool!

Senator Harolﬁ Hughes

�</text>
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                    <text>Havadhor 27th. 1972

Dr. Martin KItI.
Cliniaul Research Branah,
National Instituxe of mental Health,
5600 Fishers Lane,

Eockvillo. unryland 20852.
Dear Hurtin,

Your timely sugsostion

to:

discussion of EC?
t panel APA
Program Committee.

at tha
I regret their decision, but am not nurpriced.
I In.not enthusiastic about an evening round table.
knaving how fragmanted thesa mansions beoana, resenting
their charge to :$t¢ndaos. and anticipating a room with
APA

has not haen accepted by the

unsatisfactory seating, air handling. slid» projection, ate.
My

frustrntion led

Hy

bunt regards.

ms

Al Freedman, as oneloned.

to write to the

new

President,

8ineare1y yours,

Fink. M.D.
Professor of Psychiatry

Max

MF/ié
Enc.

cc. 8. Secunda

T. Williams

8. Katy

J.

F.

MhGaugh

Pitts

�</text>
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                    <text>73sB~6h3~A

Dr. Stanley Zunker.
Chairman, Researoh Committoc.

VJ“ Heapital.

Dust Doctor ﬂanker.
At the time I submitted our request for the use
of lwomethaﬁyl at the VAR, I acted that we were
intorectod in participating in the collaborative study
program. In dincuasing our participation with Dr. Sanual
Kain in Whahington, be indicated that it wuuld be necestary
fbr the rasnarch cummittoe at the institution to
speciriaully apprave the eneloaad protocol.
I am submitting this protocol as nu amendment to
cur note ta ran. :nd ask that this be reviewed. In reading
this protocol there are no significant differences from
the ywogram that we had planned to estdbllth.
(You should know

that I participatcd in the

devulapnsnt of this program, and have bean asked to be on
the Steering Committee for the avalunﬁion).
Thank yum

far your aocperation.
sincerely yours.

M3:

rink, 3.3.

Professor of Payehiatry
MF/ij
Rue.

�</text>
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V

5’

W11 9th.

3

Dr.

E

J.

Zubin,

new York State
722 mm 1681:}:

5
7'

3w York, NJ.
Dear

21$
:
5;

:
3‘

1973

Institute,
thtmria
at.
,

Joe,

I concur with Charlie' a suggestions that you
are the lagical person for this enquiry. I would
be grateful if you would review it and either:
approve on behalf of the APPA, if you deem it
advisable; or return it to me with alternate aévice.
Sincerely your-a.

a»

m

Fink. Rd).
Professor of Psychiatry

was
he.

�</text>
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January zhth, 1973
Stevnn F. Zornetaer, Ph.D.,

Assistant Professar, Dept. of Hauroseience,
university of Florida College of Mhdicine.
Gainesville, Florida 32601.
Dear Stav%;,

After some delay v. are submitting all the reports
of the ECT meeting to v.3. Winston &amp; Sane, Inc. fbr
publication. As we can meet their deadlinan, they have
pramisad kc deliver the final yublication by Septembar
1973.

.

I thank you for your contributicn and an dnlighted
to hear that ycu are continuing to study seizures.
Sincerely yqurs,

an: Fink.
MF/id

M.D.

�</text>
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March

6th,

19?3

Steven Eomtur, PhJ). ,
Department or

Rmmimu,

University of Florida.

Gaineaulle. Florida

32601.

Stem.

Dear

have submitted your pcper to the publisher, Ind
both he and I mum '3th Figure 10 (a photoyuph of
a brain 311cc) will probably em out poorly. Is it
possible to have that. mlwtogrnphcd to providc tn 1m.
with gram contract!
We

Many

thanks.

Simuroly yours.

Mu Pink, 3.3.

Protuaor of Psychiatry
Mir/1.1

'

‘

gamma:

~.

4‘

�</text>
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                    <text>73I~639

April 25. 1973
Steven Zornntzer, Ph.D.,
Dcpnrtmnnt of Heurosniuncon,

Uhivuruity of Florida,
Guineaville. Florida 32601.
Don: Stava.
The

Therc are two quastians rqsnrding memory function and

eluctrical nativity. In a seixuro naeessary for tbs alteration
in unwary function! Tb-vhat extent doe: thn electrode
locatian noaify the errant: on memory, regardleoa of whather

the entrant is seizureuindncing or subthronhold!

In our wart vith patients we hava rnpactedly fauna that
the applicatian or electrical current through alestrodea
whiah ﬁrm eithar an can side er bitemporal, do not change the
behgv&amp;or of thn subject. unlenl a actauro (convulsion) oeaurs.
With nubthronhold Iﬁimnlation, tummovunenx does not occur.
In my enrly work in did check an manory changes and axing
vary gross anasuroa VB dié not tinﬂ changes in manor: function
with tubthrtshold aﬁimnlation. In those dart we wtro
dalightud bnasuan v. did balilva that improvamnnt and memory
worked with
changas ”hat hand in bsnd. ﬁbre recenxly, as
unilateral oloetrodg glaaannnt. and datuilad unwary tasks
fbcusnod on varbal and nonuvutbtl. visual ar auditory

it

parameters. vm did not npeeifionlly lack for the effects of
the Iﬁbthrashold stimulation. With seizures induned through
unilateral aleetradoa, we and other: haw: fauna that manory
ahnngon an occur. Th: tyve and dagrco or unwary change in
diroctly ralated to tbs looa$1on of tha clactrodal. Thus,
bitempornl electrode placuunnt elicit: grattar engages in
vurbul and auditory manory tasks than any uniluter&amp;l electrode
Electrodaa ova: tbs non~aam1nant hemisphere
placumant.
unutlly cliait lesser degreus of unwary interference, and thus:
are tbcuaacd on non~vurba1. visual tasks. I! unilateral
e1n¢trodus are pinced ova: thc dominant hemisphere. thc
chanson in.munory tanks are sraaﬁar and more manltunt on
verbal. auditory typo tasks. Lately, one or my cavarkcrn has

”Ar

w

'

for yuur additiannl figure uhieh I think
gublishar has not yut reeated to our submission.

Thank yau

in better.

‘

-

:¢.’Y"u

r.—

Iwmw

z—meIr—f

:

WW?“

«3sz

W'Wﬂr

‘

�Steven Zorneteer, ?h.D.

Ayrll 25, 1973

~2—

series of experiments with the electrodes hlfrontelly

done a

placed and showed that the

memory changes

are even less than

the unilateral nonwdominant. Unfortunately he did not do the
specific tests to separate verbal tram non~verhel aspects.
Thus, ve would have to answer our questions that in man
tasks are interfered with.when aeituree (eonwuleione)
are p-oduced and the type and degree of’memory task inter~

memory

is

ferenee

aamehew

related to electrode location.

first question. whether

a seizure is necessary for
tunetion, does not find en answer
in human literature to my knewledge. I knew the eentroverey
is real in the week that Jim and other. hsve been doing. In
yeur work, I would be particularly sensitive to some measures
of eurrent intensity and duretiea. eleetrode location, but
also evidence for selsure (and its duration) end/or convulsion.
From your letter it’d: not clear to me whether yen can eleerly
parcel out the contribution of eubthreshold and eupre~
threshold electric currents.
an

My

alteration of

memory

With regard to your lent question, the evidence is
quite eleer that if electric currents are intredueed over
one side of the scalp. theme may or may not cross eontrelaterally (es reflected by the development of canvulelons
or electric seizure activity) and this transfer depends
directly on the emeunt or entrant delivered.
The aeeampenylng ante to ell the participants in the
eenrerenee will bring you my to date as to the statue of ear

volume.

my

best personal regards.
Blneerely yours,

Mex

Fink,

M.D.

Executive Director

MF/id

ﬁne.

‘

�</text>
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                    <text>Vs“

Deaeﬂber 18th. 1972

Lillian Zach, Ph.D.,
Dirtcﬁar.

Behool Psychological

services.

Chnirnnn. Dn’nrtment of Educational Pnyehology tad Guidanoc,
Fbrkam: Grudnnxo School of Eunnnitio: and Social Salamect,

luv York, $.Y. 10003.
Donr

Lillltn.

I ﬁbula be delight-d to discuss the "drug quaation” with
the ntudnntl‘at Yodhivl.
‘

,

It

in becoming evidnnt thus tbs lnrge s¢nle edun‘tionnl
procrnns 1n youngnr and ravage: grads: Q30 now‘bosinnin; to
report that thty aﬁilulnte oxplorntton by students, and
rathcr than reduce the incidance of drug testing. tend to
inerense 1t. Anncdntully, this tundnnuy 1: en¢oula¢cd by the
an. of format drug uddieta who tend to glnnorise their earlier
life. I vauld be glad to mast with your student: and vuuld
try to than: on what v3 know dbout drug: thunnolvnt, but
concluding that the luau. 1! net the pharmacOIOgy of the drugs
and their dangers. bu; rathnr the tacial issuns of why vc
encourage our tavnrito drugs (alcohol and nicotinc) and
aixeourlge some.

I shall be away u good part of Janunry, but am quito
free in derunry. Call a. at hams any evening, or at Stony
Brook during the any (hhh~2hh7, arts code 516).
my

best regards.
Sineorcly yours,

ﬂux Fink, M.D.

Professor of Psychiatry
HF/id

_

�</text>
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                  <elementText elementTextId="106520">
                    <text>«mlwnrm

r. rr'

r;

..

~-;.~

own...”

=1W --

7...,

LufaﬂVéh"

042'

,.:‘v—O’uw.~uv.1...)1mW

7:.."1‘J‘W9-“L‘ﬁz'cﬁ'syuox'A‘:'n.ny')v}jr«lqv-yuvw7

Irv—“w.uh”

my:

7.11:»-

Var WM,

n

.v-v

w

u

y...“

., _.
.

r,

l

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-

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,u

m, , Y

~.- ,

.._

l 7,.

..

v

w

,w;

.

|
4

mambo

.
.

ﬂaptenbcr 28th, 1972
To:

Btonlqyllollol,

.

,Chairnan,
FROM:_

.

.nax Fink,

M.D.
Doporﬁmont

of Psychiatry

M.D‘

Isunamcwz' Laborotories :05 T91, Bow school Building

I have roviawod the druvinga for T~l, and nascent that
teaching goo research laboratories ho dotined and soon opoeisl
rhesus»; ho inoorporatod in tho building as it is oomplotod.

.4

u

,

anv.-zu,x..

r.

.Iy-

H

1. ';$~;ﬂyﬁrsiol*$*
Boeinalns with the note that 877 is set aside as an
informstlon retriovol facility, I would suggest Laboratory
560 be unsigned to tho Eﬁo~oonputor, and rooms 800, Th5, and
hos be planned as ahiolded rooms for polygraphio recording.
should you wish udditlonol laboratories, hos and he? can be 9%
designaood laboratories. what: proximity to the computer
for processing may be advnntasoouo.

If such a douignotion is Etna, than the following
supporting units eon be assigned:
Data Processing
Shop ~ #357

-

#6053

'

Storage. Equipment Luborutory - #606
Qrfiooa - I507, 508. 319, 373, 519, 827
2. szghgotrio Dita Prooosslga

statistioal work of the Dopartmont.
for
keypunoh. calculation, files,
laboratory
dots processing terminals. Perhops 607 should be doaignnted
for this use.
For data annlysin oud

you V111 wish a

*3-

aim

Rooms

87?, 86?, 887 raunin as designated.

�A faa1lity tbr obsarvat1on 1nd recording (both audio
aaa visual 'TV') would be useful Suggc-st 121,be single
interviewing ream; 221_a group (largo) 1ntarviev1ng roam; and
33g.aa the observer—reearding roam. Thia V111 requ1re cable
canneations and windows from Th2~557~797.

Rooms S97~598¢S99

ltbérator1es.

should be designated "psyehology"

Rooms 559, 799, 722,167 (7 603, 691) could be cqnippad
as 1aborutar1es w1thhanchas, gas, H.902, etc. If so, #151
(172
200m 1132) and 897 012 he daiignated glassware, instrumont,
15nd storage raamsy

in

6

to be daleted
thaue laboratories meet our ant1¢1yatea needs, then

’Laboratori 3

It
the 1:222mmory
designation for 597, 598. 599. 600, 601 602.
553 uhn21d be aeletoa. and 1aberute21es 560. 607, 557, 605, 606
22 re-dos1gnuted :3 outlined above.
shanid these augaastians be agreeable. I Will out11ne
the specinl requiremanta for the rooms designated._
22/13

7

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11/6/72
Stanley

rm.

see

«Mum

131.1).

W

of

was in

Mail
mm.“
W1. naming

5:

i
.

for their

night be

ml

,
~
3

24.13.

mum-ch by the new Foundation
interest“ me. I helium: that studies a!
fit the goals of this
maﬁa
foundation. Rather than my
on this abject,
that they consider
or that may maxim reviewing this prom

i

f“

Max

TM attached

3

_

101193.

10'.

“tum
1.1.

was, wimp: a letter from you

use mam.

�</text>
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Hovambar

Stanley F. Yolles,
Max

27th, 1972

M.D.

F1nk,M.D.

Hotel to Modifications.

Psychiatry

3123.62

Second

Floor,

V. A.

Hospital

The unit is designed for carrelated studies in behavioral
(pnynhia$ric) analysis, psyehophyniology, EEG and eamputer

cerrelations, and biachnniatry; for studies of patients and
volunteers.’ Animal studies gr. plaansd for the medical~
surgical animal cantor (36).

l.

Laboratories deaignatod an EEG, paynhophyeiology,
Phyniology are $0 be eenﬁrally air canditionad; and each to
have sink, hot and acid water. air source.
2. Comyuter faaility
cooled air conditioning.

to have the usual separate water

3. Cdilinga in laboratories to be lowered ("doublenhung")
with removable tile: to allow cabling from laboratories to

computer

unit.

h.

Laboratoriea noted‘with (SP) to have no windows;
separate air handling; and special sound reduction insulation.
5. Bioahemiutry laboratories to have the usual air/gas/
hot and cold water/special want: and vacuum lines.
Three rooms to hava one way absarvution windows;
appropriate dark shades far natural vindoou; available fbr
observation, either airection in group dbservation room.
6.

7. Classroom to hawe curtains that can aarken roam;
scream (aukomntic, electrical) and special. projection cabinet
far 2 x 2. 3% x Mk and 16 mm. sauna.
(a)
-

(In)

8. Hbrknhop, computar, physiology laboratories to have:
110 volt outlets 30 amp. soparate line each roam to central
main panel.
Computer to have 220 volt 100 amp, no volt. 100 amp lines

for computer and air eonditioning.
(c) Fluoreaeent lights in laboratories to be shielded.

MF/id

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                    <text>a

T-l Mbdification ~ 01
Rovembor 28th, 1972
mo:

8. Yollea,

FROM:

M.

SUBJECT:

Preliminary Space Allocationu, Research Tower.
Floor T—l - "Psychiatry”

Fink,

M.D.

M.D.

floor consists of a aorvioe core, and four quadrants.
architect's guidelines, the SW quadrant oontains
offices for the chairman, conference rooms, secretaries services,
etc;
The Twl

Following the

The remaining quadrants were designed

Quadrant

hospital.

ﬁE

oontains tho passage for connection to the

As on initial
reeommended:
SW:
KW:

HE:

SE3

for chemistry.

step. the following general assignmonts are

Chairman, Conference, Lecture rooms, Clinical
Psychology
Neurophysiology, Biological psychiatry

Biochemistry, physiology

Library, neuroysychology, payehophyaiology

Should those designations be acceptdble, many rooms require
modification. At this time, deletions of permanent installed
equiyment are recommonaid for the following rooma:
8W:

557 ~

A

598~A

599 ~ A
A
597

-

7h2-A

A

A

s

'
«w'v

v?
v
:rw

~mWIIW.u-w7m'xmwmnw

jww

NV:

558

-

A

7&amp;3

-

B

600.1:
601 - A

�J“.
.4

B.

Yollen,

«2-

M.D.

603
167

HE:

'172

-

Hovember

28th, 1972

A
C

~ A

SE: 606 ~ A

560 *
559 857 ~
827 -

A
A

A
A

Th5 ~ 3
A.

Deleta central bench, hood, wall bench. Leave wall cabinets
only if general purpeae stcrage. Leave 110 v. outlets,
minlmum 2 each, h walls. Leave l HCW sink in appropriate
corner.
’

cold room. leave shielaing. wall bench and
Delete DI, ather benchea.

B. For
C.

Delete

all central

all fixtures

F15, 203‘
.

MF/iJ

on one

Remaining rooms

HOW

sink.

benches, wall benches, except bench ﬁith
wall, preferably the unit éesignated

to remain

an planned.

�</text>
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                    <text>www.mrm—gﬁi

.m

Hovcuber 23th, 1972

‘

Alexander J. Regen. Fh.D.
619 U, Armitaga Street,
Chicago,_1111noin 6061h.
Dear Doctor Hosea,

'2 I

'

the opportunity to ratd ynur raport,
"?nychelogy 291: Honda, Junkioa and Hines." ﬁummar,
1971. It is interesting, partianlarly 1n yuur
indapendant reviaw of the Illinnis BAP. It was my
reeollection that Jatre and Shaster also enrrioa out
studies of the deaenditioning moael of drug abuse
traatmenti Kan emittad_roferance to this. In your
visita, was the cyalamocing pragran moribund? I: this
ha&amp;

technique no longer availdble to tho
Many

Illinois resident!

thanks.
Sincergly ynurs,

m

Pink, 3.1).
Professor of Paynhiatry
MF/id

�</text>
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                    <text>November

28th, 1972

Turan Itil, M.D.,
Missouri Institute of Psychiatry,
5&amp;00

Arsenal Street,

St. Louis, Missouri

63139.

Dear Turan,

Enclosed

is

my

contribution to your volume of
EEG. I trust it meets

Pbyahotropic Drugs and the Human
your critique and is acceptable.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry

Max

arm/1.1

Enc.

�</text>
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                    <text>Hovaubor 30th, 1972

Hubert Petersen, Ph.D..
Division at Narcotic and Drug Abuse,
ﬁatiennl Institute of Mhntal Kealth,
5600 Fishers Lane.

Bockville. Maryland 20852.
Dear 30b,
1

:3 enclosing copies of all tha correspondence

(some af.whieh you may already harm) received tram Dr.
Beaubrun during an» lutt savoral weeks. The people in

Jamaica are vary interested in pursuing the praposcd studies
of canndbia and havu gone to the trouble of tracklng down
the possible naurces of misunderstanding and clarifying
any questionable issues about thnae studies.

It'vould seen.tha$ this correspondenae might answar
that Hashington has and it would be in
overyono's best interest to reconsider the studies at

any concerns

chronia ganja user: in Jnmni¢a.

These atudiea are particularly relevant as parallels
to the experimental data currently balnz collected on

chronic hashinh users in Greece.

Sinceroly yours,

MF/ié

Ens.

�</text>
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                    <text>Ocﬁdber 30th. 1972

J. Kittin Peary,
national Institute of Health,
Dr.

E.I.N.D.B.,

Bethesda, unryland anolh.

‘Deur Doctor Peary,

Following the presentations at the Amarican EEG Society,
I diucussed the chromatographic arug tinny! with Dr.
Gallagher. Ho—susgcotod ynu may be sponsoring a symposium
in Haw York in December, presumably in conjunction vith the

AREMD

maetings.

If so. and 1f the session: may be open. I vmuld
appreciate a program and the details or participation.
many

thanks.
Sincerely yours,

ﬂux Fink, M.D.

Profasaor of Psychiatry

MF/ij

�</text>
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                    <text>Hovember

Dr. E.

Dr.

30th, 1972

Pellegrino

Mhz

Fink

of Health Sciences Center
subjects dated 11/20/72
study of Cannabis. B. Dornhunh
Memorandum
Human

Committee on Research Involving

I would like to respond to the three reaervntionn expenaaei by
the committee in its latest review of the Dornhuah proposal.
-.-r

rv"

resume/y

:n.

—

3
Lin?!

,-rw’3’-we;au

(a) The committee raises the qneation as to whether voraening
academic perfbrmanoe can be ascribed to participation in this

experiment. In the acute experiments the subject: will have
trials of substances which they have admitted taking
on other occasions. In the chronic trials we already have evidence
,that 21 day exposure has been without barn, both at the Rev York
Medical College and in studies in Boston. we can not any for
core that a 35 day tincture woulo be without harm. but we
.antieipate none considering our previous experiments and our
observations in chronic hashiah.nsera who hare been exposed to the
compounds for more than 30 years. One of the requirements for
participation in the study program in a psychiatric interview
and psychological tests which provide some information as to the
stability of the subject. In our preVioua work we have been
fortunate, perhaps, in excluding candidates who have experienced
instability of affect or behavior during interviews.

single

(b) The committee enquires an to whether identification acne
marijuana user places him at risk. As I mentioned to the committee,
there has been no effort made by legal authorities to enquire for
such information. In the one instance, in Boston, the investigators
refused to give the information and the matter was dropped.

It in clear from the present federal and state regulations that
the use of cannabis does not seen to he a risk, but the possession
nay~be a risk. We have in the pant maintained possession ourselves.
in the hand: of the investigators. and would undertake this study
only after we have fulfilled the appropriate federal and state
requirements.

(c) The committee enquires whether enunoretion or $5 a section or
for a summer nerticipotion are excessive « an undueiindncenent.

$h00

�Dr. E.

Pellegrino

~2~

Novamher

30th, 1972

have been awarded funds. from thﬁ muons]. Institute of Manta].
Health in prior years and heme paid. $5 an hour and $300 for a. four

We

participation. We do not bullet“ that the same paymant for
acute sessions would be massive bars, but it an nypropriate
comittea of tha university suggests a. 1m:- ree we would be glad

week

t0 try

1154:

increased the fee. from $390 120 $h09, since we have
increanad the participation from k muck: to 65 weeks.
we

I m attnehing t «ow of tha amount

mats thc suggestions of the emitted».
xiv/13

Em .

form which we

believe

�</text>
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                    <text>O
Kovumher

Dr. Leonard E.

30th, 1972

ﬁaiselaa.

Chairman. 008183,
Surge C, 113.

Bear Doctor Meisalaa,
Enclosed please find copies of tun révised consent
forms for tho prospeativu studies on canndbin. One form

is designated for the acute studies and another in fur the
chronic.
Sincerely yours.

ﬂax Fink. M.D.

Profausor of Psychiatry
MF/ia

Enca.

�</text>
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                    <text>ﬂovmber 30th, 1972
Mr. K. DeAmond Kirkpatriax.
Assistant Direetor,
Charlotte Drug Educatiem Center. Inc. .

“16

E. Manhood

5t. .

Suite "201,
Chnrlotte. North Carolina
Dear Mr.

Kirkpatrick,

2830b.

'

In addition to the usual treatmnt modes which are
well known, such as mthadone maintenance, detoxification.
rehabilitation. etc. . we would suggest that you include
in your program some Macmillan of narcotic ammonium .
I know this is difficult since there are only a fur centers
am a few peozgale qualified to discus: this complex subject.
but I am sure that with the help of the National Institute
of Rental Health you will ﬁnd what you need. I an encloung
a recent paper which may be or same help.
Sincerely yours ,

Fink, M.D.
Professor of Psychiatry
Max

10/13

ﬁne

at

�</text>
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                    <text>Department of Psychiatry

September 3, 1972
Mr.
CRC

Jerry Becker,

Manager

Press Division

Chemical Rubber Company

Cleveland, Ohioo
Dear Mr. Becker,

Last spring, you wrote regarding the publication of a
volume on the narcotic antagonists. At that time, I was in transition
to a new university and was unable to see how I could find the time to
undertake such a mission.
Since then, I have reviewed much of the literature on the
and it may be possible to put such a volume
together during the next 6 months.

narcotic antagonists,

If this is still of interest, please write again.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>September 6, 1972
Joseph Mendels, M.D.

V.A.

Hospital

Dear

Jot,

Philadelphia, Pa.

no

errors

I

Your publisher has done an

excellent

joh—-

for I

have found

I have sent the sheets for the indexer, as requested.

is

one suggestion. For me, the "M.D." is a part of
my name. I think it is reverse snobbery, an insincere attempt at some
egalitarianism or democracy to list authors names without their
principal degrees. I would ask that my name be listed on page 331

There

as "Max Fink, H.D.".

It is also

embarrassing to me, for the type to be so large
for the name. Perhaps, in resetting the line, the linotypist could
use a typeface of the same size as the text, like 10 point ?
Many

thanks.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

P.S. Since the text will appear late in 1972, I would appreciate
my affiliations as:
Professor of Psycyiatry, Health Sciences Center,
State University of New York at Stony Brook; and
Adjunct Professor, New York Medical College.

�</text>
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                    <text>«

aw.

&gt;

~

—"«v,.-V

September 6, 1972

0
_~—~~~~~a—*—
M

E

R A R D U

M

TO:

A. M. Freedman, M.D.

FROM:

Max

SUBJECT:

Effects of Chronic

Fink,

M

M.D.

Methadone Intake on Performance

The impact of chronic drug use on performance
and throwing question.

is

a

recurrent

For most drug evaluations, various issues

have come to the fore which

raise doubts as to the generalizability

of the task performance for the following reasons:
(1)

Sample:

usually well motivated, specially

selected subjects participate.
(2) Task:

life,

usually

artificial in relation to real

often too simple.

Setting: examination is in air conditioned, sterile
environment; boredom and fatigue as factors are excluded; distractions
(3)

and competing

stimuli are excluded.

�A. H.

Freedman, Md).

(4)

September 6, 1972

drug dosage

Dosage:

contrast to real

life,

is haphazard

where intake

overdose and withdrawal are

Isbell (1948).

The

irregular,

and

studies of driving performance

criticized for these reasons;

(Kielhalz) have undertaken ”field”
Gordon’s

and

real factors.

For example, some recent

with cannabis have been

is well controlled, in

and the Swiss

tests.

studies contrast with the earlier reports of

conclusions (that methadone improves performance)

are unconvincing since the issues (l~4) above apply.
As

an

aside,

Gordon has presented

EEG

data which contrasts

with our findings: he claims methadone normalizes the
KIéIDJ
methddoneslows near frequencx’produces bursts, egg.
gogglggiggz

EEG; we

find

data is insufficient to support

(l)

The Cordon

(2)

Performance

any contention .

Should be encouraged and accident

tests,

under

field conditions,

rates, absenteeism,

and

X

accept-

able products used as indices to evaluate the questions raised by
the Commission.

�</text>
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                    <text>September 11, 1972
Welter Eeamen, PH.D.,
Queens College

Flushing,

New

M.D.

York

Dear Walt,
As I mentioned
ECT.

programs in

before,

we

have terminated the study

I want to thank Mrs. Heldman for her efforts, and I
enclosing herewith the final checks due from the College.
Please thank her on
My

my

am

behalf.

best regards.
Sincerely yours,

Mex

Fink, M.D.

um

.5.
‘

a
..

52.19%,

1

�</text>
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                    <text>Vlmm-Wmﬁﬂw‘wmww

W

September 12,-1972

Alfred S. C. Ling, M.D., Ph.D.
Associate Director, Clinical Pharmacology
CIBA—GEIGY

Summitt, New Jersey

07901

Dear Dr. Ling,

Following your letter of August 11, we checked our records
and sought follow-up data by phone in each case studied in the two
clinical studies of GP 41299 (your studies A69-650 and A70-1903-3).
The question of interest was whither the patients had become
pregnant
at any time during or since exposure in 1969-1970.
We traced 8 patients, and none have been
pregnant during
or within a year of exposure.
We

failed to trace

4

patients.

Enclosed are the laboratory standards in use in our
GP 41299 studies, and the changes made in
the procedures in August, 1971.

laboratories during the

I trust these data are helpful.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>vxtww’ﬁh-Kvxwwc

Department of Psychiatry

September 14, 1972

Harris Isbell, M.D.
Professor of Medicine
University of Kentucky
Lexington, Kentucky

Dear

40506

Harris,

Our studies in Greece have progressed to where we have
written demographic reports for NIMH but have not condensed these
for public presentation. We are now administering hashish, marijuana,

and THC—delta-9 in cigarettes, with a THC-delta—Q content averaging
140 mg., and recording the physiological and behavioral
effects.
These data are being collected now, and the data collection should be
completed by November.

w.

W

w

'0."—

.,

Enclosed are some reports which may be useful, including the
cannabis psycholis, which has been published.

.
,7,

V..."

,,
7v:

&lt;wymv

Sincerely yours,

N'va’vﬁfﬁtﬂ-"vvm—r'w‘

..
,.

my»

"aw-w-

r—‘vn—

www—W

.w-

-w-vm—w—

v

.-

“Wu-”W.“

.4

w—

”an

—v

‘m,

.mw

Max

Fink, N.D.

Professor of Psychiatry

�</text>
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                    <text>'7
A

«run—w—

1
m..."

m'mV‘r—lr.'r"r

.._.—~.

.
WM

‘

—-nv

kuW

September 15, 1972

William F. Bunney, M.D.
National Institute of Mental Health
5600 Fishers Lane
Rockville, Maryland

WWI-W

Dear Dr. Bunney,

In various discussions with Paul Janssen, Sidney Archer,

and Harold Blumberg during the past few weeks, in the course of our
studies of the narcotic antagonists, I have become aware that you
and your associates are sponsoring a conference on the narcotic antag—

onists.

You may

recall, that in

1970,

Iolles,

the antagonists at the

Freedman, Martin and

York Academy of
Medicine which served a useful purpose. It would be helpful to our
work and interest to attend the meeting in November.

I organized a meeting
Is

it

on

New

possible for us to attend the conference

?

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Samuel Kain, M.D.

Coordinator,

VA—SAODAP

Veterans Administration
Washington, D.C. 20420

September 15, 1972

Steering Committee

Dear Sam,

‘I have read the protocol of the levomethadyl vs. methadone
cooperative study. The design is satisfactory, and the forms servicable.
Some

suggestions:

Side effects check-list: What is # 12 ?
Attachment C: Who fills this out, and is it to be verified
Attachment D: Is this to be verified ? By whom ?

?

References: For f 8, see attached. You may also wish to
summary of the study of the duration of methadone's cross tolerance
may be relevant to the issues of the study (Reprint enclosed).

include a

for

it

We are completing the study of increasing dosages of
levomethedyl, and the data at present indicate that 50 mg LAAM provides
blockade to 25 mg heroin for 1! hours. but at this dose of LAAM, there
are subjective complaints of discomfort. To suppress discomfort and to

maintain pupillary miosis for
The
My

72

hours,

report will he sent to
best regards.

80 mg

LAAM

is required.

you as soon as

it is

completed.

Sincerely yours,
Max

Fink, ..D.

Professor of Psychiatry

�</text>
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                    <text>Department of Psychiatry

September 17, 1972

Gerold L. Schiebler, M.D.
Chairman, Psychiatry Search Committee
Prof. &amp; Chairman, Department of Pediatrics

University of Florida
Gainesville, Florida

32601

Dear Prof. Schiebler,

Like every man who has established a laboratory and seen
have thought of the opportunities in developing a Department
of Psychiatry. Finding the working and living arrangemnets in the city
too hazardous, I recently moved my laboratory to SUNY—Stony Brook; but
I am still interested in a Department.

it

grow,

I

I am pleased to enclose my curriculum vitae
for your committee's consideration.

and bibliography

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>.M-‘t
_

&gt;9

-‘.

September 19, 1972

Reservation Manager

The Shamrock Hilton
Soutu Main at Holcombe Blvd.

Houston, Texas 77001

Dear

Sir:
Please change the enclosed reservation for arrival

Tuesday, October 10; departure the same (October 14).
Thank you.

Sincerely yours,
liax Fink ,

Li. D a

Professor of Psychiatry

MF:ig
Enc.

on noon,

�</text>
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                    <text>September 19, 1972

Louis A. Gottschalk, EILD.
Professor and Cnairman
Department of Psycniatry &amp;
Human Behavior
College of Medicine
University of California

Irvine, California

92664

Dear Lou:
Your

was

sent to
We

letter regarding

me

for reply.

methods of reporting drug

related deaths

have no system to Specifically define or record drug re~
and would rely on a search of toxicologic records, based

lated deaths,

on

the standard diagnostic manual.
Good luck

in your study.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry
Ming

�</text>
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                    <text>September 22, 1972

Ms.
The

Natalie

S. Kurtz

Psychiatric Institute

University Medical Building

2141

K

Street,

N.W.

Washington, D.C. 20037
Dear Ms. Kurtz:

All we will need for our presentation at the Psychiatric
Research Society is a slide projector. Uur slides are regular
2 x 2”.
.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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September 26, 1972

Leo E.

Bollieter,

M.D.

Medical Investigator
Veterana Adainietration Hospital
3801 Miranda Avenue

Palo Alto, California 94304
Dear Leo;

013?.

Enclosed ia a short summary of our presentation at the

flying with one of your claaamatee, Arthur Schwartz
weekend. Did you know he haa built hia own amphibian,
has temerity to fly it? Indeed, I watched him! He aende hie

I
this past
and

was

regards.

I red! your report,

and

that of the other participants,

to the Deer Lodge Conference. While the consensus supported the
visual behavioral and aynpton aspects of teating new paychotera—
of cerebral
peutic drugs, no mention was made of the measurement
as patients.
volunteers
in
effects as indiceo, which may be ea uaeful
are reaponaible in large measure for our failure to
communicate but the data of EEG claaaification studies of paycho~
reaponaea
active drugs ia really more exciting than the washed-out
some
methods
require
newer
Of
the
course,
quoted in the symposium.
be
to
recording,
egg.
rigorous attention to drug, dose, netting,
unless one is
preciae ~ control: that are difficult to achieve
with
careful. For example, we have conaiatently found EEG changesbecause
cheervers
by
earlier
cannabis ~ changes uieaed, we believe,
of methodological problems. Anyway, we are not ea depressed about
atudiea of new drugs in volunteera - indeed, it in an exciting developeent.
I enjoyed the Copenhagen meeting. deny thanka.

I an aura

we

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

HF:ig
Enc.

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                    <text>September 27, 1972
Walter Modell, H.D.

Cornell University Medical College
1300 York Avenue

New

York City

10021

Dear Dr. Modell,

Enclosed

is

a short

report,

Nalozone PUmoate:A*Long—Act£ng

Opiate Antagoniat, for your consideration for Clinical Pharmacology
and Therapeutics.

This report represents our most recent effort in developing
a useful narcotic antagonist therapy for opiate dependence. While the
formulation has specific limitations, the data and the experience are
of importance in demonstrating that extension of duration of action
is feasible. I hope the logic is compelling, so that these efforts

will continue to obtain support
Thank you

and

interest.

for your consideration.
Sincerlly yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="103673">
                    <text>v a-v- W‘s WWMW‘WAuaecnwnﬁgn

w

,

WM'e‘w-"~mm~:y&lt;s‘-«m:-rmm~ «y;

"w

»v:

“."w..m7WW\YI«*—w

'«VTF'V&gt;.IK

‘7’”.

'1 --

dumq

'11'

m

.-

,

“mu-w»

w

-'-"

er

A

-.
v

soytamber 28. 1972
Samuel

mm.

14.13”

Director; Alcohol and Drug
Dapondnnce

Service,

Veterans Administration,

thhtnaton D.C.,

20h20.

Dust 8am,

I

am

pleased ta enclose a draft of our report:

Levomathndylz

?rolongod Duration 0f Opioid Effects,

Including Cross Tolorunca to Heroin. 1n

Nun;

As we had pramised, VD completed this study during
nunmnr and damonntratod that the minimum effective
dose for clinical
in 70 mg. lavomnthadyl three time:

the

trial

i amok. I believe it would ha usefu1 for the Veterans
Administration - Collaborative Etudy to assess either this

slightly highcr.
W3 are submitting this report to the A.P.A. for
their considerttian far the 1973 wasting.
done or even

my

best regards,
Sincerely yours,

Mt: Fink, M.D.
MF/iﬁ
Ema.

w

’

1‘4

‘5
‘71:,

'
~

~u.:wxW-JF

My

�</text>
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                  <elementText elementTextId="106503">
                    <text>October 3rd, 1972
Mr. Jame: Shaw,

.rhoilitios Proerm CoordinItor5
Yica President Kellth Balances.

clzu.

Burg

Dbar Mr. Shaw,
The Departnhht of Psychiatry would Ipprccisto obt.I1nins
.,
dup1icIto IrtlitecturIl drawing: of tho following drIuingI

from 800? ProJect 32.00 Ind 32-218:
8022 Project #32400 4
'

A418
Aph38

T-l to 2-10 plIn
)
Plan
w
2-1. 2. 3, h. 5. tower
(I.

Core ”A" Typical townr

QuIdrInt

A-hho

I

AthB Quadrant III (2. 2.) Plnn 2-1 2 .3.h J.6.T. 9.10 tower
QuIdrInt Iv (a.w.) ?1In 2-1. 2. 3. 56.7.9.10 tavnr

as

A—hhs

sucr Proaqat 132-218

—

Detail drawing: Ind-x Shoot
DatIil drawings Index Sheet
DetIil drIminsl Index Sheet

EQ~1
EQ—Z
EQ—B

Enuh
Symbol 11st
EQ~107 TypicIl tower,
'

lIborItory

room

TYPical tower, lIborItory roam
BQ4112 Typ12al tower; laboratary room
EQ-llB Twpdcul tovhr, ReIIIrch IroI &amp; cold roam
EQ-llh Typical towar, lIborItory room
EQ—109

A

tovur, laborItory roan
Typical tower; lIborItory room
EQ-llB Typical tower, lIborItory roam
EQ—120 Typical tower. laboratory room
EQ-122 Twpicnl tovur, Prep. room
EQ~128 Typical tower. RIIeIreh area &amp; cold room
30-129 TVpical tower. 1Iborntory room
30—131 Typical tower, lIborItory room
EQ-133 TypicIl tavnr, lIborItory room
EQ~138 Typical taunt. RIIIIrch IpIce &amp; cold room
EQullG TypieIl
BQ~117

�Hr. Juno:

ﬁhmw

-2.

October 3, 1972

tower, shop room
Typical town». elasswnre vuuhing roan
EQ—lhl Typical tauar, dirk roam
EQ—th Typical tovur, Inboratory room

EQ~139 Typicul

~“-3.140

qulhs

Typica1 tovur, laboratory room.

xeylhe Typteal toner, liborntary roam
32—150 27p1¢n1 tawnr. ldboratory room
EQ—lSB Typical townr. research aptee &amp; cold room
whnn

these have cons to your office,

e311 an gt h22h7?

would you please

Thsnk yoﬁ,

Sincerely years,

,

Mm:

‘

as: rm.

m.

�</text>
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              <elementText elementTextId="53518">
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                    <text>U.

‘3'.

v.

_

.
..

/

October 5th, 1972

wining F.

Bunney,

um.

Division Q! Harcotie and Drug Abuse,
Entional Institute of Mental Hcalth.
5600 yilhﬁlﬁ Lane,

Rockville, Maryland

20852.

Dear Dbctdr.3unney,

IQam;ple¢ch to send you a copy of the-report of
the aliniédl an dgon the nzrcotio antagonists which

raeently campletod for tbs national commission on
Harihuanu.nnd Drug Abuse. As I anticipate the report
will be among the documsntn ths Commislion may submit

was

in the npring with-their ncxt report, its-distribution
in restrietod until that tins.
Sincerely yours,

HI! Fink, M.D.
MF/id
Enc.

�</text>
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  <item itemId="5350" public="1" featured="0">
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                    <text>«w

w

«yr-u

MA

yup

”ram—i

«nan.

z:

DWI-7

vn-

«are

”5.2-:

October 5th, 1972
Dr. William Martin,

N,I.M.H.,
narcotic Addiction Research Center,
Lexington, Kentucky.
.

Deer

Bill;
yDick.Reenich has recently extended the dose of

cycleeccine for a group of patients at MetrOpcliten
_

Hospital,

and hes

epperently,elicited tolerance to the

unpleasant effects of cyclﬁnocine. With heroin challenges,
he has observed en extension of effective antagonism
to 25 mg. heroin for more than R8 hours, suggesting that
a trial of cyclezocine en-e three times a week schedule

might be

we

._

‘21:;
,
.

"r
'm

‘-‘1m‘5&lt;"};é

feasible.

Whoderd

of

are editing for results of the studies by
M5050; and the supplies of EN-l639A from

ENDO.

Harold Blunberg told me of a meeting on the
categoniete, promoted by the National Institute of Mental
Health, and labelled the first such conference. I regret
that our laboratory has not been invited to participate;
and also regret that the history of the work in this field,
which is of such short duration, is already so rapidly
forgotten by officieldom, In addition to Resnick'e report,
which he has submitted to the American Psychiatric Association
for their May meeting, I am pleased to enclose a copy of
e summery of work on the Narcotic Antagonists, which I
recently completed. In addition to the compounds listed.
I am aware of two additional entegoniete under study in Europe
one by Jenesen end one by Orgenon « but I did not obtain the
structural formulae in time to include them in this summary.
I am very greteful to you, particularly for your 1967 review,
to which I referrdd moat extensively.
_

my

best regards,
Sincerely yours,

MF/id
Enos,

Mex

Fink,

M.D.

~

�</text>
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                  <elementText elementTextId="106501">
                    <text>October 5th, 1972

Jafte,

Dr. Jerome
SADDAP,

The White

Eonse,‘

washington, D.C.
Dear

Jerry,
I

am

enclosing two preprints of reports that
American Psychiatric Association.

submitted to the

The levcmethadyl

we

have

study confirms our previous study

that ofyour co-workers that the effective 72 hour dose
of levomethadyl is store 70 mg. we are impressed with
both the safety and efficacy of levomehhadyl and would like
to undertake a more extensive clinical trial. In calling
N.I.M.H. regarding additional supplies, I have been notified
that the supplies are restricted, and plans for an extended
clinical study are not an adequate Justification for the
release of the available supplies. I have also been told
that the restrictions in studies are based on presumed
FDA requirements for extended toxicology.
Are we, in fact,
from
restricted
extending a levomethadyl study to all the
patients at Metropolitan Hospital?
and

'

The second report demonstrates that cyclesocine can
be given in higher dosages with good tolerance develoyment

for agonistic effects.

this be confirmed,

delivery schedule.

we

initial heroin
ha

challenges suggest
hours,and should
will undertake a three times a week
Our

an entension of antagonism

to

more than

(These two studies were done at the
College and will continue at that unit).
Good

New

York Medical

luck in your efforts!
Sincerely yours,

Max

MF/ij
Enos.

Fink,

M.D.

�</text>
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                    <text>catcher IOth, 1972

All” MWI 293MB. 5

Research Ptyéhologist.
Pnyuhaahirnnablogy RatiIrah arIaah.
national InatituﬁI at Mantal HIIlth.
5600 rilhawt Lune,
Rockvillo, MIrylnnd 26852.

Allan.
I ha IﬂrI d the nglieItion. "gzgg;~:ggd HormobIr1g
*as~1n 1» $021 11’” ‘v1th intcrost. As undIrItInd thc
prapOII1.'3O patients will be assigned in h cohorts of 20 cash

Dear

I

ta hypcr~ and nornder1¢ oxygen I31 I11; with four dIyI
910~t10I1aIaz515 aIyI of troatunnt with 2 IIIIionI I day.
Ina cvuluItionI on day 16 (Ind 1 7) Thnjpr1n¢1ptl tout

1nItrunIntI arI thy ﬂichalar unwary scale, Bender Gosttlt.
steakton acrittr1e IeIle. ThIII instrumIntI are selectcd
1n pu1t, thy 1n$asr1ty at thI contrnl nervouc
refleet1ng.
II

and

system.

_

sinae'ihn Itudy Ittcupts ta rIplicItI curlior Itudiea
ﬂhtturc cauld be
the report by
Talton at
I31 natcd that tth aarriad out auroral EEG
analyses without £1nd1na ehInJII. Unfortunatcly, they did
not doaaribe the size of sample nor the tauporal rclItion of
the EEG mIIIurII to other tIIkI.
1n whieh EEG vurinbla uIrI IIIIurad, thiI
1n¢1udad.5 A: part of our rcvtnv, II road

5;

In raw1avin; th1I praposcl with my coavorkort. VI boliovn
Ihould be praat1eIl to record 320 atlplﬂl from then.
pat1cnts; to- gravide quantitat1vc aIIIurII o! traqnnney.
amplitude. and varinbility ahInaII; Inn to relate thIIe to Inch
‘uﬂllﬂrOl at behavior, part1eulIrly of eogn1t1vb partormnnca.
'ﬂl may be axillable. A Iuggestcd prubocel. bIIed an our
undorsﬁgad1ng of the project tram thI dooumcntu provided. is

that

1%

appoaded.3

Our IngsIIt1onI Ire based on an IvnranIII thIt recording
during thI actual sessionI would be too coutxy and.controln
toe difficult to ash: such recora1ng In 1nhorcnt part of the
study. Rathsr, In use the EEG nIIIureI prov1d1ng 1ndcp¢ndInt
1nétces of change: 1n brain funct1on, their extant Ind duration.
1n parallel to the measure: of cognitive performance.

�Allan RIIkin, Ph.D.

OIIobIr 10th, 1972

~2-

IhII III

WI III InssIII1n3

EEG

IIIIrdI II IbIIinId

III plIIIbo pIr1od III fur IIIlimatiIation. III III

Inr1ng

II III IIII11II analyliI.
WI

III IIIIIrnId

IhII IhIII patients

may be

rIIIiving

pIthIIIIpia III IIIII1vI IIIiIII1onI during III
record IIII III IpIIify IhI nInnIr
IIIIII of III IIIIy. TII V111
1a Ih1Ih IIIIIIIIII drugs
II IrIIIII. Binco III EEG 1:
highly IIII1I1VI Io pIthoIrIpic qugI. Iither all drug: Ihnuld
II withdrImn I1I*Ih1Ih IIII I long VIIhnauI pIr1od, ngIIIr
IbIn 3 IIIkI. IIuld II IIIIIIIry) or. IIrI ahcnld bI IIkIn
that III IIIIIII'I usual nId1III1III II IIIIiIIId Ihroughout
III IIuﬁy 1n the IIII IIIIIII III III IIII IIhIdulo as
various

during the III~IVIluII10n pIr1Id.

BIIIIII_II hIwI {IIII IIII 1nIIrw1nII1tuI1InI1 yrIJIIII
rIquirI IddiIiInal IIII, II IussIII I p110I study {Ir III
IIIord1ng IIIIIII. IrIintag of pIrIonnnl 1n III IpII1Il
rIqu1rIIIIII It the IIIII. Ind {III1b111Iy or III var1ous

IIIIIIIIII It the I1III IpIIifiId.
A “natal IiemInI would II III v1IuI1III1yI1I I! III
A
EEG
.

.

11m1tatien It unantitIIivI
paper records.
Innlyutl 1a
In 1IIIII1I1I1Iy II IrInIiInI IVIIII. Ith II short Ililuro
bIrIII. A v1IuI1 III17I1I I! III rIIordI. using III of III

IlIIIrIII IIIIrdins IyIIIII, may prav1dq IhIII IIII.
IIIII InadingI IIId III II done by the IIII IIII aiing
IhI quInIitII1VI IIIlgIII. it any II helpful
II III1I1II II III protocol.1 hIVI Iubuitted I 11st
at Ihi Iqu1pIInI vhleh vuuld II rIquirId for such I study, and
III1IIIII IhI IIIII {Ir Ibo IIIIJI inrolvbd.1£ III suggIII1InI
IIII I1Ihyour Ipprovnl I II11IVI I III IIIIrI III pIrI1I1pII1In
If IOII unnbers of IhI IIIff II SUEX-SIouy Brook Ind HIV York
more

ﬂh11I

MII1II1

cIllIsI.,

WI

I

,

ulna IIIIII 1nIIrIIIId thII

III rIporII IuacIII IhIngII

flaw, and while II hIVI no airIII IIpIriInII with
tho proIIdanI. II think IhII rhIoInIIphIlongphy any
contribuII II the IIIItioII poIId. ThI IcahninII hlVC bIIn
IIIII IIudy {Ir many yIIrI II Bocklnad State HospitIl by
1n vascular

KIIIIIh L1fIh1II.
should

I Iony of IhIII rInIrkI Io III GIthon.
III probIb111Iy If 1nI1uI10n 1n IhI study II h1gh.w
I

Ia.IInd1ng

III prIpIrI I aorI-forIIl rIviIv I! III 11IIrIIurI of

EEG

�Anon Rankin. mm.

~3~

Octabw 10th. 1972

ottoctaaﬂlﬁhwporbcrie tad nornanrie oxygen and tho methods
ywoﬁoeal to unqt tn: ﬁends at :n
inaugrltaa utudy; and apply fur the acedtnary institutional

u: unplay; nodity uh:
.

aypwovulxé

’

{uy‘heqtvresurds.
Iaincnroly yéurl.

m mat, Mm,
“Ilia

ecu Sc

..
m.m’ﬁuanﬁ
‘

-

�</text>
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              <elementText elementTextId="53482">
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                    <text>Fw—w—vrmt-mw.‘nv

“d"..qﬂ‘q‘ ,. .,.,. i or. mauvnwwww—w; 1..Ym;.m~n-wa-ta-.a—nwnmkum—mpun-hm.“rum. ~DPJ‘Q‘.‘(WmFm:n-A"‘.'Errurmuwavaw~n'u-m-V-v

on."

.7

e

‘

, —-.-. .

w”

warm uvvn.‘—‘——..

nun--01...-

—.—,

A

_

WW7

October 10th. 1972

Chief Editor,
Springer-Verleg N.Y..Ine.,
175 5th Ave..

Nev York

City,

‘

X.Y.

Since 1969 we have undertaken studies of chronic
cannabis (hashish) use, and we have established a collaborative
relationship with the university of Athens. eProressor Hires
first introduced us to the 1938 study of Dr. M. G. Btringeris.

we

our

found

this report

most

useful

and

to

make

it

available to

staff, arranged for its translation into Ehslish.

Believing such a translation may have more widespread
public appeal. we asked Professor Costas Stefanie of the
University of Athens to discuss this matter with Dr. Btringeris.
A note from Dr. Stefsnie states:
He

"And now two more things‘ One is the Stringaris book.
told me that the new edition presents only e few changes,

mainly additions to the old one and-very

is needed..

little additional work

is very willing to see his hook published in
He
called up the Bpringer-Verlay in Berlin, the firm
English.
which holds the rights, end they told him that
if you are
He

—

still'interested--

York.‘

'

you should eonteot Springer»Verlag in

New

We have translated the text (excluding the case reports),
but have not edited the typesoript. Should publication of the
translation he of intereet, to can arrange to have the text
edited end the cone records treneleted.

sincerely yours,

Mex

nr/ta

Fink, ran.

.7.

i ,1

‘.

.

,

7v

.

.w . _ V...

H

v.

w

7w- ewe

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
School Of Medicine
Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry
73SB—668

The Honorable Jacob

Javits,

Senate Office Building,
Washington, D.C. 20510.
Dear Senator

Javits,

During the past few years the President has sought
support for discontinuing research training funds. The
impact of this effort on research and teaching is far
reaching, and Representative Paul Rogers has introduced
legislation to reverse this Presidential decision.

I should now like to solicit your support for
56h0, "The National Research and Traineeship Act of
1973", when its equivalent is introduced in the Senate.
This bill would restore research and teaching fellowships
tith a) a ceiling on the total amounts to be spent, b)
a proviso for a return of two years of service for every
year of support and c) a limit of three years of support.
Such provisions should overcome most of the objections to
the previous programs.
HR

This bill would allow continued progress in the
development, through research, of safer and more effective
drugs for treating various illnesses and for the best
applications of drugs for the treatment of patients by
practicing physicians. These are matters of concern to those
of us who consider ourselves as clinical pharmacologists,

but in the broader view,.this bill will assure a continuing
flow of researchers and teachers for all fields of medicine.
Thank you

for your courtesy.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/ij

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                    <text>STATE UNIVERSITY OF NEW YORK

‘

AT STONY BROOK

s
_

‘

HEALTH SCIENCES CENTER

,/“
M

E

MO

To:

R

AN

D U

See

October 18th, 1972

M

Distribution

FROM:

Dr. Max Fink

SU&amp;ECT:

Attached

_

hit/yd

letter

from Dr. Elmer Garﬁner

Attached for your information and use is the official IND 9119
from the F.D.A. for our use of cyclazocine. This authorization
is applicable to the Veterans Administration Hospital at

Northport.

cc. to Dr. Arik Brissenden
Enc.

MF/ij

Dr. A. Don
Dr. J. Sherman

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                    <text>F:

W

October 22, 1972
TO:

Alfred Freedman,

From:

Max

Subject:

Request of Pennsylvania Medical Society regarding
002 THerapy for Opiate Dependence

M.D.

Fink, M.D.

I have read the submission of the protocol (which is
letter of transmittal, and testimonials by Dr. LaVerne.

incomplete),

Except Gﬁr the testimonials and the alleged private practice
documents are devoid of the type of information required
to assess the usefulness of the therapeutic studies. The program
lacks a theoretic basis, and except for the spurious association
between the availability of the technique and the availability of
the patients in the same office, there is no justification or

data, the

basis for the application of the inhalations in drug addiction.

Since the Pennsylvania Medical Society has already
presented the information to a most sophisticated panel (Drs. Brill,
Seevers, and Primm), it seems an unnecessary duplication of effort
for this unit to attempt an evaluation of the data submitted.
Considering the possibility of undertaking an evaluation
of 002 therapy at the New York Medical College, I would not recommend
such a course at this time: there is no basis for the study; the
risks are great; and prior committments preclude the use of our
limited facilities at this time.
As a political eXpedient, referral of this agency to
could occupy some of their time
would serve two purposes:
and effort; and if the project has merit, they have the funds and
SAODAP

it

the connections to establish the studies in the national

interest.

mv

�</text>
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                    <text>October 23, 1972
Dear Turan,
Should we nominate Jovan

letter;

If yes,

for the

ACNP ?

and I

will

would you send the c.v. and the nominating
send a seconding letter to Dick Wittenborn.

My

best

regards—— and my thanks

the American EEG.

(Did you know
My

for your participation at

that Janice Stebena is the next President

best regards.
Sincerely yours,
Max

Fink,

M.D.

?)

�</text>
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                    <text>r

5--

Wmn mum-v-

"uh-w,z-L'yvvrgw—W/vn'!wxrmmrrw.

V

,

,

uu

mmwm

w'

-

\

'.,,_

catcher

_

,

25%h, 1972

m’rm‘

.v.

A!

Br.

Lea E.

Kalli-tar.

lod1aul tartat1gntor,

Veterans Adl1n13tra31on Kosp1tnl,
3801

3

.

911a

lirnndn Ar...
Alto. Cultforniu 9haoh.

Dot: Lou.
Tho report nubn1tted ta the CIIP 1s A nunnnry of two
ruporta 1n grass. and sun. additional 111; b¢1ns prepnrcd 1n
arsc$or 1.1111. Thu yﬁbliuhoé reverts and 1n press include:
21*Duy

Administr1tion of usr1au131'1n Male

voluntlern. Cunaent Reilaﬁch in Maaijaana, pp.

115*128, 1972. (Dornbuah, B.L., Clnre. 6., Zaka.
Crown, P.. v¢11111. J; and Fink. M1)

/«

1.,
_

,

‘
I
'

le1juann, EEG and Bahtvior.’ In: M3r13uanaz
Chemistry, Phsrmneology, and Patterns of Social
U... A. Singer 1nd 3.‘Yollen (319.). Ann. N.V.
A114. 311., 191: 206—215, 1971. (Voliwkn, J1,
Dornhunh, 3., feldstein. 8., Clare, 6., ana.

rmmx.mdhuuu.1)

ltfootl of

:

1.,

9-tc1rnhynroegnanh1no1 on E26. Eunrt

ante. and “bod. Etcctnacuaeph. Olin Henaophgazat.
5:: us: (abstrnat). lgvz. (Vbluwtn. 3., norahuah,
3.. Poldntuia, 8‘, and Pink, H.)
The vultvks

ruyort, abntraetad 1a 336 el1n. Neurophysiol.
to Payuhophsrunaolngia.

has bocn suhn1tt-d

my bait rncurdn and «aﬂtrntultt1ont
to the 19!? presidency.

on your nomination

a1nncroly ynura,

ﬂux r1nk.

“.9.

9rofusno: or Payeh1atry
“7/13

WI-‘wn-‘v:nun-n

�</text>
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                    <text>October 25th. 1972

Editio Cantor

KG.

796 Aulendorf,

Wurtt,
W.

GEM.

Gantlunen,
The ennlaaed galley paoor is correct,
for the second proof.

and

I thank you

'

I ante that you have changed the word "doxepin" to
“ﬂaxepine” in the t1tle_und the text. In the German summary,
éoxapin is spellaé without the "e".

It is

my

ingresaion that dcxepin

is a generic

name which

in the United states is sold umﬂor thg trade name Sinequan.
My use of the word "daxepinntypo" was tn attampt to provide
reference he the generic name. I vauld 33k that you ruview
this report and make such ch:ngen in the spelling as may be
eonsiatent with ybur editorial poliay.
many

thanks,
Sincerely yours,

HI: Fink. M.D.
Exerciser of Psychiatry
MF/id

33¢.

�</text>
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                    <text>October 25th. 1972

Editio Cantor

KG.

796 Aulendorf,

Wurtt,
W.

GEM.

Gantlunen,
The ennlaaed galley paoor is correct,
for the second proof.

and

I thank you

'

I ante that you have changed the word "doxepin" to
“ﬂaxepine” in the t1tle_und the text. In the German summary,
éoxapin is spellaé without the "e".

It is

my

ingresaion that dcxepin

is a generic

name which

in the United states is sold umﬂor thg trade name Sinequan.
My use of the word "daxepinntypo" was tn attampt to provide
reference he the generic name. I vauld 33k that you ruview
this report and make such ch:ngen in the spelling as may be
eonsiatent with ybur editorial poliay.
many

thanks,
Sincerely yours,

HI: Fink. M.D.
Exerciser of Psychiatry
MF/id

33¢.

�</text>
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                    <text>Octdber 25th, 1972
William R. Darrow. M.D., Ph.D.,

Phernnceutieels Diviuion.
CIBA~GEIGY Corporation,
Summit. New Jersey 07901.

Dear Doctor Darrow,

I have diaeueeed your request of Oetdber 16th with

nseoeiatee, Dre. Geatannsu,

Abrams and

Jones.

my

It is difficult for

delete

all

us to accept your nuggestian and
mention of the compound GP h1299 from our report.

see it. there are two puseibilitiee. If we are
eorrect in expanding the clinical applieetione of this
compound, it would serve neither our interests. nor the
methods vhieh we used to make this yrediction, if the
report beeenn lost in the world literature because it
As we

could not be

identified.

If.9narpredietian is in error. we eun only know this
compound is assessed by other: for its anti—anxiety
anti-depressant potency, and this will only be done if
we stimulate the interest of ether investigaters as well as
the‘reeeareh staff at CIBAFGE$9Y.

if the
and

Fer these reasons we can not acaept the suggestion made
in your letter. We hope that publication will serve to
stimulate further interest in GP h1299 and thereby increase
the study and the sale of this compound.
Sincerely yours,

Hex

Fink.

M.D.

Protester of Psychiatry
MF/id

�</text>
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                    <text>rum

Oetdber 25th, 1972
Dumnld P.

Wt

master.

Klutn. M;D.,

of

Paciﬁsm

Research and Evaluation,

Hulda: Hospital.

75~59 263rd St-.
Glen 0:33, H.Y. 1100b.

baa-Don.
With regard 150 the two Mas cumming the Am.
I hare invited Richard Rania to attend the 1972 mating;
and have agreed to accent! the nomination of Jenn Simeon, 24.1).
of the University of Missouri. He will but nominated by
Tut-an Itil. Simeon worked with bath or us and we agreed to
make this
this spring.

m

mutton

.

I suggest (unofficially) you recommend ymxr snout:
attend the. meetings but they at a neighboring hotel . I
thc use of the acclimation:
am to recall the flap m
w mat: to that Islam Ind to not ucouodutim Gunner...
at the meetings themselves.
mm never was a prablan
Alternatively, tell Dick they m renown-ca peaplc for your

m

and will am at their mm menu. etc. If
Mum.
either in
in cannabis, thaw can he a "venom.

mud
m

person” for the

hoe

mm: nation.

Blncmly,
Fink, 3m.
m
Protuwr of

thutry

WI 13

w:

�</text>
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                  <elementText elementTextId="103667">
                    <text>October 25th, 1972

urn. Carol Levin,

President.

Mbtroyolitan Electroencephalagraphy Soc1ety.
Mndiaal Science Bu11d1ng.
550 First Ave..

Haw

York

City,

H.Y.

Dear Hrs‘ Levin,

I

must congratulate ycu on your fine work with the
As you may not know, I am moving

Mhtropolitan.EEG Society.
my

laboratory to the.Stata ﬂhiversity of

Bronx and

next year.

will not be in

New

York exaopt

at Etony
at rake intervals

New York

I think that

your suggestion about having a session on
and I would.suggest that you invite
aw aaaaeiate, Dr..Jon Valavka. He did participate in the
syngonium in Hauaton and has extensive experience. not only
with research aspects of drug Share, but with the clinical
as wall. may I suggest you reach him at (212) 369~7900.
drug abuse

is imyortaat,

Best regards.
Binnorolydyunrs.

MB:

fink,

M.D.

Profaasor of Psychiatry
cc. to Dr. Jon Vblevka

Mm:

�</text>
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                    <text>Oetdher.25th, 1912
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                    <text>October 25th, 1972

Dr. and.

lblitar,

Lcndclh&amp;nptutu&amp;t Nanchan,

Droncaborn$uncnatolln.

8000 thnhan 15,
Goathastrtno 33.

V. Govnnny.

hour Death: Holitor.

I

an plcalod

to unaxoae a

eopy of

the roprint you raquontod.

Cyeltsocinc is ca uzpprt-ontal coupeund vhieh. at tho
yruucnt ting. in availtblc through the Nationsl Institute of
Mcntal Health. 5600 Fishers Lune. Roakvillo, Mhrylsnd 20852.
or Sturllns Winthrop Roucnrch Institutc, Rensnalncr, H.Y.
/~&lt;

Iran our ouacrlcnco 1t 1: clout that eyalgsoeinn 1.
appliadhlo to Iarphinn .ddiction. heroin :ddictian and :11
0th.: opintc tddictioan.
Good

luck in your study!
Biaocrely yours.

ﬂux

rink,

H‘D.

Profunaor or Pcyuhiutry

ur/ia

m.

�</text>
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                    <text>'i
"Irv-I'm“

-

August 24, 1972
Mr. Gary Boyer

Div. Narcotic

&amp;

Drug Abuse

National Institute of Mental Health
Rockville, Maryland
'

Dear Mr. Boyer,
mm

.,u

-

,w...,y..-;.A...A...v

,Vlwww

application for an IND for the
Hospital at Northport, in conjunction
study of cyclazocine at
NIMB
contract for the study of narcotic antagonists, negotiated
with the
NIMH
with Dr. Stanley Yolles of SUNY-Stony Brook. The application
by
for an IND, including the FD 1571 and 1573, letters of release from
to Dr.
Sterling Winthrop and supporting data were sent directly FDA.
of
the
Edward Tocus at the Division of Neuropharmacology
On

August 5, I submitted an

the V.A.

Tuesday, August 22, I Spoke to Dr. Alan Ramsay who
indicated that a special protocol for the study of cyclazocine was
secretary
necessary. To comply with that request, I called Dr. Yolles
and asked her to send the copy of the contract between NINE and the
University, which spells out the details of the study. That protocol
was sent to your office.
On

From your

letter,

the only

special request of waiver of the
obtain

it

secretary

30

.WW

we

day waiting

omitted was the

period..

Should it be useful to obtain the IND number before we
from the FDA, may I ask that your office call Dr. Tocus'
?

Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
mv—r-

1

detail

two installations, be
Brook
on September 1;
advised that I am assuming my position at Stony
Freedman
Professor
and have agreed to continue as Adjunct Professor with
Freedman
Dr.
As
soon as
for the remainder of the present academic year.

P.S.

To

clarify the fact that I

am

writing from

assigns administrative reaponsibility to another physician, I will notify
your office. Until then, I would be grateful if you would honor the
requests from both institutions over my signature.

�</text>
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                    <text>Oetdber 25th, 1972

Mr.

My

B§

30””.

Chief Pharmneict.

Prcclinical Drug Study Saetion
Centar for Studias of ﬂareotie

and Drug Lhasa.

Rational Inatitutc or mental Health,
5600

Fishers Lane,

Dear

Mb.

Boekville. Mhryland 20852.
Boyer;

Enclosod in a raqneat fur 190 gram: placebo marijuana
and adaitional supplies cf THO-dolta»?. and marijuanu (2.65

THG~aelta~9) .

I received a telephane @311 from Professor Coats:
Stcfnnia of thy Uhivgrsity of Athmnn vhn in undertaking acute
investigations at hashiah, marijuana and TKOadalta~9 in
chronic hashiuh usara. unﬁt: H.I¥M;H. contract #h2-70~98.
He requested sufficient supplies to complato an additional
31: subjects and I shipped theaa to him from the_supp11os at
thn Kev York Hadical College. The material requnsted with
this order is to replace the amount shipped him.
sincerely yours.

Fink, M.D.
Professor of Psychiatry

Mix

WI 1.)
Sue.

�</text>
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                    <text>l-VNZWI

7W5“!!!
Hum: 6th. 1973

W

Jun-Otto Ottouon, 14.13.,
of Paychintry,

Untmsity of ﬂatworm

33W“.
and“.

Maren-kn

hl3 35 Goteborg.

Dear

ha,
I

am

pleased.

to tell

that year:- report "ﬁrstemic
will be published in our
Peyohobtolagy 0f HGT, which will be

Moohmiaal effects of

(”choosing

volm on

published by

text

Tho

you

new"

V. H. Winston gm!

Sam.

editors have man a raw modifications in your
the text "typed. A copy of the
text is maimed.

tad. vs have but!

mind

trust that than chum” meet with your approval.
In the event there are new changes which you will not
tempt. and they are minor, plane
until the galley
proof. In the event that they are user changes. I would.
We

if you would

“it

m.

critique by air
At one mint you offered to critique my report. I
damtrccdl1f1mt0tmdittam,minsnycuo
I an musing M; and would yen: with to send me a.
Mum-ion. I would be plan-ad to add it to the text. at
the approprinte place. Plan and it air mail at war
he grateful

stand mg a

when eonmienec.
it but rem.

Manuals your-I,
“Bk. ”up.
m
Professor of Psychiatry
WIN

m; .

�</text>
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October 51:11, 1972

Dr“Géorge O'Brien,
Abbot

lhth

Laboratoriel,

Sheridtn'ﬁc§d,
Earth Chicago. Ill. 6006h.
&amp;

Dear Georgy,

It vii good he'talk to you last V'Ok; -81naa than,
I have had-the occasion to read the notes on canndbis

9hish" by my_usaociate, Peter Cravn.' Ho 1: on holidtyu
new, ana will tbrnnliso a report when he-roturnn. for

the neénwhile,'the varieﬁy‘of definitions
you.

'

’

‘

'

~

’

my

baht regardn.
81ncorehy.x»A

ur/ia
Enc.

may

interest

�</text>
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                    <text>November Bid. 1972

Earl Undin, Ph.D..
Phyuhopharnaaology Reneareh Brtneh,
National Institute of Mental ﬁenlth.
5600 Either: Lune,
Rockvilla, Mhryland 20852.

Dear Doctor 03415,
Thank you for sending an a cogy at "Psyehotropic
Drug: and Ralated Campo‘
“. second edition. I hava
found the firth cdition useful unﬁ in scanning this
issue. easily found sans «xycrinnntal compounds which
A

I roeently studied.

It in a fine volume. tad I command you nnd your
aluociaten for u valuable resourcc. Again. my thunks.
Sineercly yours.

Fink. HgD.
Professor of Puyuhiatry
Mix

MF/ij

cc. to Jerome Levine.

M.D.

�</text>
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                    <text>“7383696

Jun. 15th,

1973

Hr. Erncut Tonlqy,

Contrsnts Mbnagcnont Section.
Grant: and Contracts Mnnggunnat Dr‘nch,
Rational Inntituta or Mbntal Kealth,
Pnrklnun 3163.. Room TC~26,

5600 Fisher: Lune,
nbckville. Mirylund

20852.

Donr Hr. Tenlcy,

Eneloncd 1: 3 revised contrnct yrtcing grape-.1 fur
thc atuay of nnltruannn in “The Evalugtion of ntrcotic

Antagonists" 1n respoasu t0 RIP331ME”RDA~73~225. Th1:
revision 1- 1n tn. alnunt of $165,761 for 18 months and
rcpmoscnts an extension of Han-h2»70-115.

In asking tha &amp;danstmnn$u requnstcd in our telephone
have:
aonversation

it

dnlutod item. roprcnenting

EEG;

liberatory technician tbr the
ndditional liberutory tostu;

addod a

providnd tn allounnco for travel for
subducts to attend the clinic daily while
an autpaxionx :tntun;

sad. incro;uod the aura. tram halt to full

tint to pravidc udditionnl vackond covurngu
at nnltroxono.
that tbs 'rojact Director has

1b! the added dclivury

Vb undnrutund
ndduatnonts in our pcrnit, sad

rccoannndod

in agree to comply with hit
rnconncndntions, subject only to the rcviav or our 100:1
008138, should that be nacossary.
Thank you

for your coaguration.
Bincarcly yours.

Fink. “0D.
Professor of Psychiatry
MIX

ur/i
Baa.

�</text>
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                    <text>Octobar 25th, 19??

w.- 1100 awau..
contracts

Mhnagamant Branch,

Natianal Institute'of Mental Kealﬁh,
5600 Pinker: Lane.
Roakvilla, Maryland 20852.
Dear Lee,

to be going very wall. On
steranis aallod an with two requests additional aupplioa of ennndbtg. and an enquiry an to tbs
utntua of tha funas for the period Avril to June. 1972.
I reeolleet that whea we discussed thin mama weeks
ago, the naceasary aubmieuions had been made and that you
antieipnted a review of our roqnest at that ting. may I
ask far a followup?
The work inference seams

Sunday. Professor

my

belt regards,
sincerely yburn,

Mix

MF/id

Fink, K.D.

�</text>
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                    <text>catch:
DECUE,

Disittl

30th. 1972

Equipment Corp..

Muyutrd, Mn...
Gantldnnn.

Ax the recent Annricln 320 Society naetinss, prosrunn
the
‘fbr
portrayul of consecutive change: in EEG power
dincusutd by Raginnld Bickford of LaJollg.
wore
npcctrl

htva a PEP-12 awnilnblc to us far our EEG.anamyaeu
in inquiring of your rcpronentntivo cs to thc
awni1:hility of thu programs, submitted by Bickford to
DECUE. he tuaacatod I write directly.

w»

gun

1: tbs plot portruwal of pawn: spectral arrays.

-y1¢1ding

‘

Budinnnnionnl image for chnnaon 1n tins.
DECUBY Whaﬁ is
nudbcr and how cnn

it:

avnilablo through

g copy be ébtcinod!

Mhmy

thanks.
Sincerely yours,

as: man, n.9,
Puebla“?

Proton-g. or
DIP/1.1

�</text>
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,.

A-

Octdber 30th, 1972
..y-wv,wcmnw.wu,wwmwv

Dr. Steven Khmgater.

Ilka Fifth AVQ.,
ﬁew York, N.Y.

Dear Boater Kempster.
'

At

the vrittan'roqnost of Hrs. Earriat

anclosing a copy of a

Vinita to

me

summary

1957~1960.

Axmun,

letter rogsrding her

I

am

81n¢erely yours,

Fink. M.D.
Profeasor of Psychiatry

Mix

33/15
Rue.

~m‘w-nww.

m

«rm-I

A

�</text>
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                    <text>Octobar 30th, 1972
A1

Rankin. Ph.D..

Clinia:l Research Branch.

Hational Iantitubo of Mhntal He‘lth.
5600 Fishers Lana,
Roekville. Mhryland 20852.
Deur A1,

the recent EEG mnetings, I had the occanion.to disauas
projects with various workara, inaludins Whiter
Obrébt az Duke. He in ‘aquainted with the cardiovascular
and can: of the aerebral offoctu of hypafbnrie chambers.
It may be useful for yuur project to revicv his work.
At
Queuing

Thu wanting; also aurfuood name advances in portrayal
of result: that arc buuaming inerigaingly aw‘ildble. and
which may improvn ycur proposed studies.

Bincarely yours.

Fink, M.D.
Profasnor of Psychiatry
Mhz

mm:

�</text>
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                    <text>§

October 30th, 1972
Sidney

ﬁbrils,

M.D..

Prcfessor or Clinical Psychiatry.
Central 13119 State Boagital,
Central 13119, K.Y. 11722.

Dear

Sid,
Following our diacunsionn

this morning, I

to send to

ma,

would

at tho research committee

appreciate your asking your secrdtary

for filing anﬂ/or distribution:

(a) caplet of protocols or ongoing research
programs which may be made a matter of
record at this time.
(b) invitaticna

the

and

to maetinga of a research nature

latter to

to

~

ba distributed to the committee
ether departmnnt nnmbara.

Sincerely yburs.

Fink. M.D.
Professor of Paychia$ry
max

NF/iJ

�</text>
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                    <text>Octdber 30th, 1972
Donald Klein, M.D.,

Diractor of Research,
Island Jewiah~ﬁillsidelaueens Medical Center,
270-05 76th.Ave.,
Haw ﬁyde Park, H.Y. lloho.
‘

Long

Dear Don,
;

;

Folioving our discussions at the research committee
this morning, I would appreciate you asking your secretary
to aenﬂ to me, for filing and/or distribution:
(a) copies of protocols a! cngoing research
programs which may be made a matter or
record at this time.

g

(b) invitations

to meatings of a raaearch nature

~

the lattar to be aistributed to tbs committee
and to othar dapnrtmwnt members.

g

z

Sincerely yours,

Ml: Fink. N.D.,

Professor of Fsychiatry

g

M?/1J

�</text>
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            <elementTextContainer>
              <elementText elementTextId="53232">
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              <elementText elementTextId="53233">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>,

-

arm-Vauyr-errw—w-

VZJELAPTI

July 17,

1972

Samuel Gershon, if. D.
Department of Psychiatry
New York University College of
Medicine
550

New

First

York,

Avenue
New

York

Dear Sam:

to organize the equipment needed for the EEG
monitoring of high concentration oxygen effects in aged patients at
NYU.
To provide some basis for instructing my staff, can you provide
us with a provisional protocol, so we can fill in some methodologic
details we have found useful (§;§,, duration of prewdrug mecording,
electrode location, alertness monitoring, tape identification, amplification of signals, £33.).
be able

We

may

If

no protocol

exists,

can you share the following:

rype, age, condition of subjects (cooperation level)

dumber and frequency of experiments

Duration of each exposure
Period after exposure subject
chamber (and

available for

will remain in

EEG).

To save a few days, send me a copy
Long Lake, New York 12847.

to c/o General Delivery,

Sincerely,
rialt Fink ,

Eli. D 0

Professor of Psychiatry

Ming
cc: Jerome Levine, M.D.vf

oxygen

�</text>
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              <elementText elementTextId="53223">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>August 9. 19Y2
Mrs. Roberte London
Contemporary Drug Problems
515 Oxford Street
Wentbury, ﬂew York 11590

Dear'ﬁra. London:
The suggestions by Sennela, Hoehetetter. end the

mittee (Contamporery

Drug Problems)

Lari?

Con-

for e heroin delivery experimﬂnt

are well motivated, but they do not consider the severe practical
problems posed by the suggestions. In selecting heroin. they select
the drug with greatest risk (high lethality for dose), shortest do»
ration (requiring moat repeated administrations) and least stability.
They propose an experimental

patients

who have

delivery in

failed other treatment programx.

livery is to provide

all patients

trial for heroin

100

to

200

The heroin de~

a method of engagement, and within the

year,

are to be admitted to other treatment programs, partic«

ularly narcotic antesoniets, methedone, or drug-free.
The principel benefits of the program will be the incorporetion of a small additional group of addicts into a prevailing treat~
meat regiment (which, presumably, they bed once before

as a vague

test of the British experience.

rejected);

and

�.hm. uoberta London

August 9, 1972

base proponents cannot be
homework,

for

moving done

for besides the questions that are raised

moral, legal, and
from the

commended

historical grounds, I

would

raise

practical Ipharmccological) point of

View.

on

their

social, ethicnl,

some

questions

Heroin, morphine, methadone, and levouethadyl represent feur
compounds

(Opioidsl

they are most similar in

on a continuum:

their

patterns of physiologic and behavioral effects it man and animals.
They exuibit patterns of crosantolerence, for each can substitute
for the other, and each
achieve cos

may

be given by any bodily

raute

and

still

effects. Their principal difference lies in their dura-

tion of action, with ueroin'e effects lasting the Shortest, usually
from 3

to

6

hours, and levomethadyl the longest, from

36

to

48 ﬂours.

duration is important in selecting appropriate dosages, for
with short acting compounds, physicians have the most

difficulty in

for their patients.

Thus, in see

stabilizing rue effecto they

wish

looting heroin. the authors opt for the most difficult and most ex‘
pensive delivery system.
we

and from

it is

have had extensive experience with heroin

that experience
and

pleasant bodily effects.
and unusual changes in

recall

it's

other problems for heroin:

We

propenoity to produce a variety of unhave observed

seizures (convulsions),

heart rate, respiration.

sufficient irregularity as to lead
patients with caution.

two

stability, requiring careful handling for

a compound of low

sustained efficacy;

can

administration,

us

and senaorium with

to administer heroin in our

�Hrs. Roberto London

prevailing

A

Anguet‘S, 1972

View

of drug dependence emphasizes the

signifi‘

cance of conditioning and learning theory an the basis for etiology
and as a key

to the alleviation of the

In suggesting e here

syndrome.

i

oin delivery system, the author! disregard this
one method of

cipel advantages of

this paradigm have merit.

methadone has been

its

However, should the authors wish

repeated injections,
adone, which

select the

edninietretion, the repeated intravenous, that will

enhance dependence, should

route.

View and

why

One of

the prin~

usefulness by the oral

to engage their patients

by

have they not recommended intravenous meth-

is achieving

some vogue now

in Brithin,

and has the

ad—

vantege of a longer duration of action and less frequent administra—

tion?
Granting a successful delivery system for heroin to a select
group of

patients,

what

is the anticipated gain? That these patients

will be available for after—care programs, of methadone and cyclazocinel
If that is the real goal, to reduce crime by buying these patients to
participate in the eyeten,

would

it

not he more to the point to

more

adequately finance and increase the number of treatment programs so

that

more
The

patients

can be more adequately

reed selected by Samuel: and Hochetettcr is one that is

easy to recommend, but for

potholes.

treated?

Should

this reader.

their enthusiasm for

one

that is full of rut:

engagement not

they would consider the expansion of levonethedyl1

and

pale, perhaps

trials

es e more

�mw‘

are. Roberta

August 9, 1972

London

logical substitute for heroin
for

Don

and methadone; or

if their

enthusiasm

Quixote causes can be sustained, they coy investigate the evi~

dence for the development of a long acting narcotic antagonist.2 Such

a development has theoretic, therapeutic, and prophylactic possibil-

ities to

commend

from public

it,

and

yet is receiving the bares: of attention

authorities, while

much eneggy

is dissipated

on the pro-

motion of heroin delivery.

Sincerely yours,
ﬂax Fink,

3.9.

Professor of Psychiatry

MF:13

1.

Zaks, A.,

H.

Fink, and

i.

E. Freedman:

Treatment of Opiate Dependence.
2.

Iink, H.: Treatment
giarcotic Antagonists.

Levomethadyl

J.A.M.£., 220:

in Heinteuance

811—813, 1972.

and Prevention of Opiate Dependence with
Contemp. mug Ptoblema.

�</text>
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                    <text>August

7 , 19 72

Mr. Gary Boyer

Biomedical Section
Center for Studies of Narcotic
and Drug Abuse

sational Institute of Mental Health
5600 Fishers Lane
nockville , Mary land

Dear Mr. Boyer:
To

provide parallel information in New York for our studies
we request the following addition-

of cannabis constituents in Athens,

al supplies:

CBD

CBN

(crystals)

5 mg/amp.
(SSC 69780)

24 amp.

10 mg/amp.
(SSC 61565)

12 amp.

Deltae9—THC

3 amp.

(SSC 69682)
1 gm/S ml/amp.

The
Many

appropriate

BED—222 C

form

is enclosed.

thanks .

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:ig
Enc.

�</text>
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                    <text>August 9, 1972

David S. Haskell, M.D.

Senior Psychiatrist

The Commonwealth

of Massachusetts

Department of Mental Health
591 Horton

Street

Boston State Hospital
BostOn, Massachusetts 02124
Dear Dr. Haskell:

be in

fer

I will be in Europe until August 21.

On my

return, I will

York and can meet with you on any Tuesday or Friday. I pre8/22, 3/25, or 8/29 as in September I will have additional comNew

mittments.

Please call my secretary at 212-369-7900 (ext. 245) - let
plan to come, (10 a.m. at 5 East 102nd Street, 8th

me know when you
Floor, Room 33).

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

iﬂhig

�</text>
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                    <text>x
&lt;-.~,

7'

-.
w

,—._-

w.

an”,

August 10, 1972
yww‘wwavmwﬂ-JW-n

Allan Ramsay, M.D.
National Institute of Mental Health
Rockville, Maryland 20852

ewaquup4m‘n

Dear Allan,
-vu-.r.wa-

N,

nag-'3'

..a:a,,.g.—~

Separately, we have filed an IND for cyclazocine for the
on-going studies at the Metropolitan Mental Health Center, and I ahve
requested Dr. Levine to institute the proper procedures with Mr. Boyer
to sustain our supplies. He will tell you that we are treating about
80 patients daily, and while the majority are receiving 4~5 mg/day, there
are at least 12 who receive 8—11 mg/day, and we are proceeding in a
few to 20 mg/day.

Paralleltstudies of Z~cyclazocine are in progress. For
the present, we have adequate supplies, but these should he exhauseudd
within three months.

file

for chyclazocine, or will MIME
provide us with the supplies to continue the ongoing studies under our
Should we

new

contract

of the

FDA

a new IND

?‘

If we should file an IND, will you request the cooperation
regarding the extent of the submission ?
Will additional supplies be available through Mr. Boyer or

from Sterling-Winthrop

?

Meanwhile, we have hegun the study of haloperidol; the
animal pharmacology of diprenorphine is delayed by supplies from
England, which have been promised for later this month; and the study
of BC-2605 has been delayed by an administrative problem, which we feel

will

be resolved by the end of the month.

Thanks, again, for your help.

Sincerely yours,

:_.

ZV'N-aq

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
FIVE EAST 102M) STREET

NEW YORK, NEW YORK 10029
DEPARTMENT OF PSYGIIATRY

August 10, 1972

Nathan S. Kline, M.D.
Research Center
Rockland State HOSpital
Orangeburg, New York 10962
Dear Nate,
Once again, I must agree with you. It would, indeed, be
a most unconstructive expenditure of our funds, for the State of
New York to re-assess the many unsupported claims of ortho—molecular
therapies. The megavitamin approach is so poorly documented, and so
dependent on parallel and concurrent therapies, particularly ECT
and drugs, that the burden of proof should remain on its proponents.
The probability of exploitation by the proponents is indeed
and
I concur in your request to Ben and to Alan, to put the
high,

State's funds to better use.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Miller
CONFIDENTIAL:

Not

for Distribution

�</text>
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                    <text>August 11, 19 72

Chairman,

Internship Selection Committee

Dear

Sir:
Mr. Heywood Zeidman

is

known

to

me

as a summer research

trainee. During the summer of 1969 and again in 1971, he participated in the drug studies of this department. I found him to be
intelligent, enthusiastic, cooperative and nighly motivated. He
was enthusiastic about the effects of drugs on brain functions and

worked hadd.

I have seen ﬁr. Zeidman frequently during the
tried to answer his many questions about the
of clinical psychopharmacology. I believe he will be
active intern and should approach his work with skill
and hdve

past few years

special problems
a dependable and
and energy.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>agaaaggaga
Angult 11. 1972

1‘0:

Dr. Robert Levine and Dr. Robot: Ronnie}:

PROM:

Dr,

SUBJECT:

ORDERIHG CYCLAZOCIHE FROM KIM}!

ﬂu

Fink

I have filed the necessary

forms

for

an IND

for cyclazocine.

Paragraph 3. indicates that: future supplios are to be

obtaingd from

Mr. Boyer

at

N133.

Paragraph 4, indicated that Dr. Runny, in to recaiva routin-

clinic reports.
Plane contact Hr. Boys: or Dr.
.

of cycluocine.

Ramsay

far additional suppliu

�</text>
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NEW YORK MEDICAL COLLEGE
FLOWER AND FIFTH AVENUE HOSPITALS
70:

Alfred

FROM:

Max

M.

Fink,

The

Freedman, M.D.

DAT;

M.D.

SUBJECT

August 11171972

Attached

attached proposal for a joint study between Dr. Inturrisi and

Dr. Levine

is

a valuable addition to our on-going

studies of

levo—

methadyl.
This information
an

information

is sent to

you

for your files,

and

to suggest that

letter regarding the collaborative study

appropriate College authorities.

be sent the

�</text>
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                    <text>November 4, 1971

Dr. Lester King
Editor
.EMA

535 North Dearborn Street
Chicago, Illinois 60610

Sir:

Dear

We

are pleased to submit the report, "l—Alpha—Acetylemethadol
Dependence" for your consideration

in Maintenance Treatment of Opiate
for the Journal.

This study describes similar clinical results for l—slphaacetylemethadol given three times a week to daily methadone. Should
this prove generally applicable, the saving in illicit methadone and

its

consequences can be great.
Thank you

for your consideration.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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December 28, 1971

Dr. Hugh H. Hussay, M.D.

JAMA

535 N. Dearborn

Chicago,

Illinois

60610

RE:

REF:

MS

#3263

Dear Dr. Hussay:
have reviewed the data in our study of “t-Alpha—
Acetylmethadol in Maintenance Treatment of Opiate Dependence”
and find that some of the interesting relationships can be presented in tabular form. We have made up such a table, and it
We

is attached.

it

seemed somewhat lengthy, we indicate a section
that can be separated, and the data presented in two tables.
As this is a matter of style and appearance, we will abide by
As

your decision.

Thank you for your kind consideration. I trust that
the reputed excessively high price of the base material for

will soon be reduced, so that more ex~
tensive clinical tests can be done. Publication of this exper—
ience may serve to stimulate a more rapid governmental and in-

Esalpha—acetylmethadol

dustrial response.

Sincerely yours,
Max

Fink , M.D.

Professor of Psychiatry

bﬂﬁig
Enc.

�</text>
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                    <text>August 21, 1972

Merritt

Dr. H. Houston

Association for Research in
Serrano and ﬁentcl Disease, Inc.
722 West 168th Street
York, dew York 10032

ﬂow

EB:

Dear Dr.

Merritt:

l have

recommend him

known

for

Dr. Taylor

alrssdy

ﬁichasl Taylor since 1968, and am pleased to
in the Association for Research in Rervoul

membership

and Mental Disease.
who has

Michael Taylor, ﬁ.D.

is

made

an innovative,

inapirtd

young

investigator,

significant contributions to studies of schizo-

phrenia. While a resident, he undertook independent research in the
influence of the sex of offspring on material psychosis. His work
has been highly commanded.
Sines his return from military duty, ho has undertaken clin-

icsl responsibilitiu sndsustsincd his research interests,
cusing on
cxpcrincntcl anxiety.

him

for

I so sure he will contribute to the Association

membership.

now

fo-

and recommend

Sincerely yours,
Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>August 21, 1972

Horritt

Dr. H. Houston

Association for Rssssrch in

ﬂames

and Mcntsl

722 Wast 168th

New

York,

ﬂow

Discus. Inc.

Straat

York 10032
RE:

Richard Abram; PM).

Merritt:

Dear Dr.

I

msbcmhip
a plasud to propose Richard Abrm,Moots}.forDisossa.
I

in the Association for Rssosrch in ﬂorvous and

have known him since 1968, when ho rejoined tho

"11.1).

staff

as fallow.

intsrostsd in ECT. and bacsns tha projact director of our
evaluations of. unilatoral and bilateral 301'. as nsds important contributions to thst evalustion, and has continued his snthtsissa for
this problem.

Ho

wss

prassnt,
biological studias,
At

ho is sctuslly angagsd in s vsristy of psychoand I an contidsnt ha will contributs to tho

lusting: of the Association.

Sincsrsly yours ,
Max

Fink,

21.1).

Profusor of Psychiatry

�</text>
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                    <text>w

.mw

——.———..__..m

W.—

...

w—w-p—

—._.—.w

August 21, 1972

Gareth Blane, Ph.D.

Reckitt &amp; Colman
Hull, England
Dear Gary,

for the supply of diprenorphine (M—SOSO),
arrived this morning; and I which I immediately
delivered to Dr. WOodard in Virginia, who is carrying out the
Thank you

15 grams, which

pharmacology

trials.

anticipated, the National Institute of Mental
Health and the special office in the White House have announced
the organization of a number of contracts for the clinical evaluation
of narcotic antagonists. The amount announced was $2 million, and this
sum includes some funds for periodic meetings on the subject of
As we

antagonists.

present schedule at Woodard provides for the completion
of the studies by the end of the year; and we should be prepared to
undertake clinical trials soon thereafter.
The

My

thanks for your help in providing

this material.
Sincerely yours,

Max

Fink, M.D.

Professor of Psychiatry

mf/

�</text>
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                    <text>mmrm mm

_

"5'

‘1'-

August 22, 1972

WWn—v—vmwm—u-wvwrvm—wW"

,.

w-

IV“ Fe Bum.tt, NJ).
ﬂedicsl Research Division
The Lilly Research Laboratories
Eli Lilly and Coapany
Indianapolis, Indiana 66206
Dear Ivan:
Your letter regarding citations of methefrone and nethajade
as trade names for levonsthadyl aroused some anxiety. I checked my
files and than called Herck.

(1) Math-Jade
(2)
E

g

'

Hethefroae

to another

is,

as you suggest. a formulation of methadone.

is not a

Merck trademark. It seems
compound, unrelated to levo-ethadyl.

to belong

Thank you for bringing this to my attention. I believe it
the JANA staff that added the trade naaes to our article. and
should they wish to correct their records, I am sending a copy of
this note to the Editor, Ir. Hussey.

was

Sincerely yours,
Fink. M.D.
Professor of rsyohistry

Hex

HF:ig

cc: Rush Eussay, ﬁ.D.

‘

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                    <text>August 22, 1972
Dr. Jerome H.
SAODAP

Jaffe

The White House

Re; Diprenorphine (M-SOSO)

Washington, D.C.
Dear Dr.

Jaffe,

you know, we have undertaken the pharmacologic testing
of diprenorphine (M—SOSO) to comply with the interpreted regulations
of the FDA, to permit us to assess the clinical pharmacology of this
compound in opiate dependence. We have had some difficulty in obtaining supplies of diprenorphine sufficient for these toxicology studies,
but did receive, this week, 15 grams from Reckitt &amp; Colman-- sufficient
to complete the animal trials.
As

if the

These
compound

trials will be completed by the end
is 'safe', we will apply for an IND,

to undertake the clinical studies in February, 1973.

of the year, and
and should be ready

have been advised by Dr. G. Blane of Reckitt &amp; Colman
that future supplies will have to be obtained from Lederle Laboratories.
When we attempted to obtain some supplies from Lederle in May/June, we
were told that they were disinterested in such studies.
We

believe that the assessment of diprenorphine for opiate
health possibilities. Anticipating difficulty
in obtaining supplies in 1973, I am writing at this time to ask your
assistance and advice as to the best procedure we may follow, to
assure an initial supply of 15 grams for human studies. The availabilitt
of a supply of M-SOSO in February, 1973 will permit us to fulfill one
of the committments of the NIMH contract 42-72~207.
We

,3..-

w,

,.

arr

”my-n.-

dependence has public

Thank you

for your assistance.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

cc: Alan Ramsay,

NIMH

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                    <text>August 23, 1972

Mr. Gary H. Boyer

Chief Pharmacist
Center for Studies of
and Drug Abuse

sarcotic

Fishers Lone
Rockvllle, Metylend 20852

5600

Deer Mr. Boyer:

Enclosed is a copy of our ongoing protocol for the clinicel
evaluation of cyclazocine 1n the treatment of opiate dependence.
In part, this protocol amplifies the contract, ﬁSM~AZ~72~207 between
ﬁlﬂn and Dr. Alfred Freedman of the New York Medical College.
You

will note that

we have an ongolng maintenance

and e new group being inducted
Thank you

for your help.
Sincerely yours.
Mex

Fink,

M.D.

Professor of Psychietry

Hing
cc: Alan

3133

Ramsey

papuletion;

to high dose cyclezocine (to

20 mg/dey).

�</text>
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                    <text>August 24, 1972
Mr. Gary Boyer

Center for Studies of Narcotic &amp; Drug Abuse
National Institute of Mental Health

Rockville, Maryland
Dear Mr. Boyer,

Ref: Cyclazocine

August 5, we submitted the appropriate FDA 1571,1573,
from Sterling Winthrop, and supporting information
to obtain an IND for the study of cyclazocine at the New York Medical
College to Dr. Edward Tocus, Division of Neuropharmacology, FDA.
On

letters of release

Following a telephone

August 22, I submitted a protocol

you.

call to Dr.,Alan

Ramsay

on Tuesday,

for the study of cyclazncine to

In re—reading your letter of August 8, I believe the
delay in obtaining an IND may be occasioned by the fact that the
information was submitted to Dr. Tocus directly. Perhaps, an
intervention from your office may release the appropriate IND
designation.
Thank you.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                  <elementText elementTextId="103656">
                    <text>August 25. 1972

Frank S. Caruso, Ph.D.

Assistant Director
Clinical Pharmacology
Bristol Lnborntorioo

P.0. Box 657
Syracuse. New York 13201
Dear Dr. Caruso:

Hhilo we are anxious to undortako studios of

BC—ZﬁOSa, we

from the Health and
are required to obtain additional permissionwhich
is being doalt
Hospital Corporation. There is some deity,
we ccnnot
dissolved,
is
impediment
that
with by the Collage. Until
begin the planned atudiao.

Sincerely yours,
Fink. MOD.
frofoooor of Psychiatry

Mix

33:13

�</text>
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                    <text>August 28, 1972

Jouethan 0. Cole,

M.D.

Editor. Poychophermecologie
Boston State Hospital
591 Morton Street
Boston, Hesoechueetto 02124

Dear Jon;

I am pleased to submit the enclosed report, "A9~Tetrehydrocannebinol Effect. on Baum Bleetroencephelogru, Heart Rate, and
Hood" for your consideration for Raychophanmacolagia. In this study.
we have demonstrated an equivalence between the effects on physiologic
measures of smoked As—Tﬁc and marijuana, as well as dose related effects. The study e110 provides evidence of Eacobehaviorel relations
for this psychoactive compound.
Incidentally, I wont to thank you for recommending my eppoint~
went to the editorial advisory board of the journal — I trust I will
be able to support the quality of the reports in the journel.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Hex

Hfzig
ﬁne.

�</text>
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                    <text>August 29, 1972

Morris B. Bender, M.D.
Professor of Neurology

Mt. Sinai Hospital
New York City

N

Dear Morris,

I very much enjoyed your report on a theory of acupuncture.
I tried to relate what little the popular press describes
about acupuncture to the DSS data, the more I am impressed that DSS
represents a reasonable way to study the process.
The more

of the formation of an NIH committee
enclosed unpublished study. The 1956-1959
quantitative measurements provided a better means of studying D85,
and in 1963-64, when I began to play with a CAT, we designed the
enclosed study to demonstrate the cerebral components of sensory
interaction. We found evidence of interaction in the AEP but could
not relate these changes to reports of extinction of stimuli.
sent

me

to

The announcement

my

The

files for the

exercise does demonstrate a

problem in acupuncture, and

may

be of

way

to study the DSS
you or your committee.

interest to

Good luck in the studies. Perhaps, DSS will yet become
established as the explanation for the"hypnosis' phenomenon which
is now becoming the talk of the psychiatric community.

Sincerely yours,
Max

Fink, M.D.

�</text>
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                    <text>August:

so, 1972

EEEQEAEEEE

To:

1. B. schwartz

FROM:

Max

SUBJECT:

Attached

The

Fink,

M.D.
PD

attached

PD

Form-

forms U111

transfer staff to

47-072—7, follow—

ing the guidelines of Mr. DcLucenn; use son: ”on campus" funds of

the

KIHH

contract 41r809~lg

and do son: housekeeping

41-382~3 which ends 9/30/72. and providc
and a change

in

my

for

some

to close out

leave for Br.

Crown

status.

Missing 11 ch.

PD

for: for

Dr.

antanaga.

Also. ch. juatificction page: for Mt. DcLucanc (to be added

to rcvitcd budget)

and a request

to hit! a nuts: to rcplacc Hrs.

Thomas.

�Giordano, ruignod to toko position in mother city.
plocuont deferred to Soptonbor.

D.

A.

Thoau promoted to coordinator of inpatient oorvicu.

plnconont roquutod.
B. Riemann)

J. Roldan)

B. Boddio )
R. Mayan )

RoRm-

Rouarch uoistmtu and technician: mignod
during July-Auguot. Replacements appointed
includo:
Loslio Suntan, Pat Sibony,
Carolyn Poinior, ﬂark Koala“. (1/2 time).

L

replace am of the services of A. Thomas, as coordinator
of the cyclazocino trutment program. we have promoted .‘iiso
Frmces Waiter at a higher salary.

To

hov- oxtonsivo data requiring are-programing of our
computer unit. Ho roqunt the addition of Ira Snapper, progrmor
analyst for six months, offoctive 9/1/72.

We

now

-

�</text>
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                    <text>Angus: 31. 1972

Mr. Fred Stunner
IBM

59

ﬁaiden Lana

ﬂaw York, ﬂaw York 10038

Ben: Fred:
our intention to accept responsibility for the 18H 1800
at 5 East 102nd Street, effectiva 10/1/72. This
be
transfcrrcd to SUNY~Stony Brook later this fall.
cquipment will

It is

and leased keypunch

the

IKE

Please

make up

tha neccsscry contracts for maintenance

1800 and the kcypunch

rcntcl, effective October 1.
Sincerely yours.
Fink. M.D.
Executive Dircctor

Max

on

1972.

�</text>
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                    <text>‘i‘
91‘,“

August 31, 1972

ﬁr. Fred stunner
13m

.

59 ﬁaiden Lane

ﬂew

York, New York 10038

Dear Fred:

Following our contract, we are hereby notifying 13% that
the maintenance contract on the purchased 1800 be cancelled effective
9/30/72. Title to the 1800 will be transferred to the International
Asaociation for Psychiatric Research, Inc. and that organization.
requests a maintenance contract effective 12:01 a.m., 10/1/72.

Pleasc prepare the necessary documents for our meeting on
September 6, for release by ﬂew York Medical College and acceptance
by IAPR of both the 1800 maintenance and keypunch rental, to proviﬁe

for ontinued service without lapse.

Sincerely yours,
Me: Pink. M.D.
Professor of Psychiatry

,MF:ig

�</text>
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                    <text>:.,,..v-~.,

4

c

.

‘

www-mu

VT.

.u. “WWW".

“1,...- fJ-{C‘PI-r‘-&gt;'~m‘~ unit‘wzrIn" -,....

“We,“

&lt;,

ﬁn

gr

,

April 4,
Henry

Brill,

1972

M.D.

Pilgrim State Hospital
Brentwood, New York

Dear Henry,

I have just completed reading the

first report

of the

Commission, and I want to congratulate you and the other members for
a most balanced, realistic review of the issues and facts, as well
as for the judicious recommendations. It is a fine document, and
I trust the nation and the states will follow the recommendations.
You
My

should feel

justly proud of your participation.

best regards.
Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

�</text>
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“.5

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{-W

BNDD—

April 4,

Department of Justice

Registration Branch,
1405 I Street

Washington, D.C.

1972

Room 711

20537

Gentlemen:
At various times during the year, in conjunction with
grants 18172 and contract h2-70—98, I have imported to the
laboratories in New York, various components of cannabis and
various synthetic opiates and antagonists. In the past, I have
obtained the appropriate import permits, as these were needed.

NIMH

Similarly, on occasion, our co-workers in Europe,
request samples of these substances for research purposes, and
requested export licenses.

we

have

I an writing at the suggestion of Mr. Steven Stacy, to
obtain the necessary registration forms to register as both an
importer and an exporter of proscribed substances under the various
limiting schedules.
BNDD

I already hold,

on behalf of

my

laboratory, the various

certificates for studies of scheduled substances.
Thank you

for your cooperation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

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                    <text>nur:

wv

.

.u

-vv-~

~

-"\ nee-Immmﬂ't": -w~»,v.—.‘a-w—»vw»vw~

.

-v-":'.-l-:::-Nv«~.

"Ku'rrvnw'rnvwrr-A‘n

._

w

v

(«a 1-,.» .

~W~

”vow/MN?

wu-

r-mwa: ,

April 5,
Louis P. Bozzetti, M.D.
Commission on Marijuana
Washington, D.C.

&amp;

v w

-&gt;

r

~-

-

'

.

-

.7

u

..

war

w-v

urn-w

-

n

1972

Drug Abuse

Dear Lou,

I have just read the report of the Commission, afetr
the
hearing
special program with Governor Shafer last week, and I
am writing to congratulate the Commission and you for the fine work
that you have done, in putting the marijuana issue in the perspective
that seems to me to be appropriate and necessary. I do agree that the
prominent unknowns are the long term effects, and hope that some of
the studies now underway may answer some of the questions.
appendices.
I

It is
As

know you

will
My

a

fine report,

and I look forward to the

I understand

it,

best regards

and congratulations to Jack as

your work

do as good a job on

is only partially done;

the other problems of drug abuse.

well.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>April 6, 1972

Dr. Samuel C. Kain

Director. Alcohol

and Drug
Dependenco Service

Veterans Administration
Departmcn: of ﬁedicino and Surgcry

“tubington, 9.6. 20b20
Dear Sam:

Enclosed is a copy of our original levomethadyl protocol
(dated 1/19770) and a suggested one for 1972«73, dated 3/31/72.
In the latter, I have tried to indicate a possible program of in—
terest to the V.A.
'

-

Please feel free to adapt, modify, or use this as you
find useful.
I look forward to seeing yen on April 28.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

3F:13
Enc.

may

�Alfred Freedman.

April 6. 1972

M.D.

I haw found Dr. Volavka a fine rasearchcr and teacher, and
a find electrooncepbalogrcphcr. and I commend him to you and the
faculty for promotion to Associate Professor.
A

copy of his curriculum
cud expat-1mm.

to hit industry

vitae is attached.

and

it attest:

Sincerely yours,
ﬂax Fink,

5.0.

Professor of Psychiatry

ﬂing
ﬁne.

�</text>
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                    <text>April 6, 1972

Dr. Samuel C. Kain

Director. Alcohol

and Drug
Dependenco Service

Veterans Administration
Departmcn: of ﬁedicino and Surgcry

“tubington, 9.6. 20b20
Dear Sam:

Enclosed is a copy of our original levomethadyl protocol
(dated 1/19770) and a suggested one for 1972«73, dated 3/31/72.
In the latter, I have tried to indicate a possible program of in—
terest to the V.A.
'

-

Please feel free to adapt, modify, or use this as you
find useful.
I look forward to seeing yen on April 28.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

3F:13
Enc.

may

�</text>
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                  <elementText elementTextId="106467">
                    <text>‘W’“WKV‘—l\vnnv'l

--

-

.

\w

n-‘vwm.

.w»

.v—«w

,

.H

r-_'—‘I|‘r-v—-&lt;a(v-

-

’ r’v’lu"wr»vrvl'
-rr'|—..--rr
-

JV“

April 6,

,

‘_m,.n~,w‘

.._

1972

Walter Essman, Ph.D.
Professor of Psychology
Queens Gallege
Dear Walt,

Enclosed is our check in
activities during the past quarter.
Many

payment of your consulting

thanks for your help.

Sincerely yours,
Max

Fink, M.D.

1..“

,

ww.._.,-n-

~',w--|Y

"a”...kmwr 7.

,_....

‘

�</text>
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                    <text>V‘x,

April 7,

The Medical
10 Columbus
New

York,

Society of the County of
Circle

New

New

1972

York

York 10019

RE:

Oliver Todor Nikolovski,
250 East 87th

New

To Whom

It

May

York,

New

Street, Apt.

York 10028

Concern:

I have

known Dr. Oliver Nikolovski since he joined our
1969. He is well qualified as a psychiatrist, and is
recommended for speciatty rating under the Workman's Compensation

faculty in

Law.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig

M.D.

Assistant Professor of Psychiatry
23C

�</text>
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                    <text>April 7,

1972

Dr. Jonathan 0. Cole

Bostan State Mospital
Beaten. ﬂasaachuaetts 02124

A

a»!

fkﬂmm

é‘

Dear Jon:

B'L‘u

I very much enjoyed the sessions in drug models of schiz~
&gt;ophrenia at the A.P.P.A. I was stimulatad to summarize some of
the discussion. and cialose a draft for your consideration for the

publication.
My

best regards.
Sincerely yours,
ﬂax Pink,

3.9.

Professor of Psychiatry

HF;ig
Enc.

�</text>
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                    <text>”W

April 10,

£8:

To when

It

Hay

1972

Robert Sharoff. 3.3.

Concern:

I have known Dr. Robert Sharoff since 19ﬁ6 ~ first as a
co~worker in substance abuse, and lately as a member of the faculty.
At the time I joined his staff, I kaew very little about opiate abuse,
its management or its psychopathology. I found him erudite and willing to teach, not only me, but the residents.

excellent were leader, a fine and patient teacher.
a methodical and careful worker. He is well liked by the staff,

and
and the

he

is

an

patients.

pleased to recommend him for a position of psychiatric
teaching and treatment, and aéminiatrative clinical leadership.

I

am

Sincerely yours,

Professor of Psychiatry
:Eﬁig
cc:

Robert Sharoff, M.D.

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                    <text>April
Fred Clark, M. D.
Robins Cb.
1407 Cummings Drive

I], 1972

A. H.

ﬁichmondL

Virginia

Be; Labelling

of

Butaperasine (Repoise)

Dear Fred,

I am pleased to answer the inquiry regarding the labelling
of.Repoise (butaperasine), limiting its application to patients with
chronic mental disorders.

I have

studied butaperasine since

1964,

assessing the

clinical effects in chronic schizophrenic patients; the EEC and clinical
relations; the effects of'concentrate (syrup) Repcise in acute mentally
and in association with Dre. Itil and Holden at the Missouri
ill;
Institute of‘Psychiatry, have been acquainted with their data on the
effects on clinical laboratory tests and the EKG.
In these studies, and in reading the published data, we
to be an effective antipsychotic agent with a
low profile of'extrapyramidal effects. Dosages can be increased rapidly
and the therapeutic effect can often be observed in 3 to 4 days. In its
EEC profile, putaperasine exhibits a characteristic hypersynchrony of
alpha activity, enhanced amplitudes, decreased variability of'frequencies,
and in higher dosages, enhanced theta and delta activity with a reduction
in fast frequencies. This profile is similar to piperasine phenothiaaines,
such as fluphenasine.
have found butaperasine

In the clinical studies, its activity is similar to fluphenasine,
in acute and chronic cases. From this point of’view, the implied
limitation to chronic cases appears arbitrary:
fhe difficulties in differential diagnosis is great, and
is
it often impossible to decide whether the patient is acutely ill,
a relapse in a chronic illness, or an acute exacerbation in the
course cf'a chronic illness.
both

Zhe symptomatic

is not specific
these
the limitation is

response to phenothiasines

for schizophrenia, but is related to the

symptom complex. we view

acting in a non-specific fashion, and
thus arbitrary. For example, patients with anxiety often show a reduction
in this symptom, regardless whether the symptom is part of'schisophrenia

compounds as

�_

.~

.w

.

,_.

,

.

r

-7.

”y,

“.2“, .,. 7...,

... .-

.w “my...“

, .'.- .1,

v

m._ N wwrv

T,

w....,....,., 1.....vww-sw. »—.=- a...“

w

3.,

--

n

.-

.._. ,. ..- .

.7

PW -,

m,:'dﬁlw “Veqrvxv .rr.w

. .

.

.

gnaw

v&lt;,."'l).‘5a .

W'WW"

~,—

NW.

.

or a part of an anxiety syndrome; similarly, the sypptom of psychomotor
agitation often responds whether in schizophrenia, depressive psychosis,
or senile agitation.
In

my

experience the decision to use a therapeutic agent
on a clinical diagnosis, but on a symptom profile,

is usually based not

it

and some elements of history. From this point of view,
seems arbitrary
and an unnecessary implied limitation on the decisions of the physician
to continue the labelling restriction for Repoise for chronic cases.
From another point of view, the limitation restricts the
teaching of the use of Repoise. In teaching residents the principles
of psychopharmacology, it is a special burden for the teacher to attempt
to describe the use of butaperazine and note its limitations. It is
much easier to recomend the use of fluphenazine, for which no such
limitation is implied (and incidentally, for which a variety of form-

ulations exist).

I trust

these

comments

are useful.
Sincerely yours,
Max

Fink,

M. D.

Professor of Psychiatry

Ref:

Therapeutic Studies in THerapy Resistant Schizophrenic Patients.
Cbﬂg. Psychiat. Z;488-493, 1966.

Clinical Laboratory Test Standards in New Drug Trials.
1—8, 1967.
J. Clin. Pharm. &amp; New Drugs,
_7_:

Organic Treatment

of Schizophrenia. In:

A.Freedmand&amp; H. Xaplan (Eds.), Williams
pp. 661-664, 1967.

Textbook
&amp;

of Psychiatry,

Wilkins, Baltimore,

Treatment of Chronic Psychotic Patients with Combined Medications.
Neuropsychopharmacology, Excerpta Medica, Amsterdam, 101601020,1967.

Differentiation of Psychotropic
9:267-—280, 1968.

Drugs by

EEG

Analysis, Aggressoloﬂe

Liquid Butaperasine (Repoise) in the Treatment
Mental Health Clinic. Curr. THerap. Research

of Psychosis in a

_1__1_:

57~63, 1969.

.&lt;~.'—VI'.A.\

�</text>
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                  <elementText elementTextId="106463">
                    <text>"‘3

_,-/__

“

.~.

.

-

mm..—

2“,»;

~,m~-—w-W..vv—;.m.~_v

v'}.

vs.-

,..&lt;.--- w,“

"3*"- wave N'va—w‘rnt“

,‘mvmr w—vwv

W's:

“v...”

n

... n» nv—vwv. an,“ ,s s.

er.» :r.

n1!"- --.v-~w

m

—.

wrrv

-,,,..v»ny~,-~m—

W-»

1

new.

7er

mam-n»

mv

April 24,

Fritz Freyhan,

1972

M.D.

St. Vincent's HOBpital
New York City
Dear

Fritz,

Since I received your invitation to edit a volume on
drug abuse, I have made many efforts to put the issue together. Many
of the men who ordinarily would be capable of contributing complain
that they are over-committed with their working assignments, or
have already contributed chapters to other volumes.
My

suggestion that the program of the

ACNP

be the

focus of the volume seemed an acceptable solution. But as I

started

to plan that session, I find that my committments to EEG, ECT, and
my move to Stony Brook occupy so much of my time that I cannot
undertake that responsibility at this time.

Fisher explains my dilemma. I still
program, ﬁnder another chairman can form a fine
volume for your series; and I hope that this may be useful to you.
Meanwhile, please excuse me. The tide of the times is such that I
must expend my energies in less politicized and more regarding
fields of study.
My

believe that the

My

letter to
ACNP

Sy

thanks for your consideration.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                  <text>Correspondence</text>
                </elementText>
              </elementTextContainer>
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    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
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      <elementSet elementSetId="1">
        <name>Dublin Core</name>
        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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              <elementText elementTextId="52874">
                <text>Correspondence to: Freyhan, Pritz</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="51">
            <name>Type</name>
            <description>The nature or genre of the resource</description>
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              <elementText elementTextId="52875">
                <text>Text</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
            <elementTextContainer>
              <elementText elementTextId="52876">
                <text>mfp-05-00-026-2-204</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="52877">
                <text>1972 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="52878">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="52880">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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              <elementText elementTextId="52881">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="52882">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="52883">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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              <elementText elementTextId="79490">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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              <elementText elementTextId="86051">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="92612">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="99173">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
