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                    <text>Q,”

..

. .mn. «av-m...

\' vanvumwvx-‘-w—m

,—

,

“V

p“. ..r

..._

v .,

w... ew‘ V.ﬁ_.,,...\v.w,.,,.,..e

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733B:Oh6ct

February 13, 1973
Thomas

Williams,

M.D.

Department of Psychiatry

v.a. Hospital
Salt

Lake

City, Utah

Dear Tom,
be pleased to know that with this mail I am
to the publisher. I have heard from
manuscripts
first
Seymour today, and his section is in the mail to me. With some luck,
the various pieces will be to the publisher by the end of the month,
and the sections for the Archives to Dan Freedman as well.

sending the

As

will

for the

APPA,

there is a simple solution.

Knowing

that

would be a hardship fer some mebera to attend meetings regularly
they were resident west of the Mississippi or in Europe,the

there

if

You

Association established a category of Corresponding member. You
obviously fulfill the requirements, and I would suggest you write
to Jonathan Cole (Boston State Hospital, Boston, Massachusetts 0212h)
requesting transfer of classification. Should this arrive before
Council meeting at the end of the month, I am sure that this
change can be accomplished. ( UnIOrtunately, I do not recall if the
corresponding members pay dues or not—- ask him. )
My

best regards.
Sincerely yours,
Fink, M.D.
Ptofeeaor of Psychiatry

Max

w—n-

A...» &lt;w"‘b1.m:» Fm.

.

n.-.“ -~

.

�</text>
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                    <text>TEL-533
v

3':an 15m: , 1973

v

-

w-wr—

m-

-_
—.-:

wsgz'zrgwrvuﬂwrwv'“

3W

Canter for Stadium of

Kutiantl

“2133’"?!

911mm,

Gary B. Ban-r, Chief
Program
auction.

lunatic

a.

Drug Abuse.

Institm a! 1mm Health,

5500

”abort

Dem-

m. Boyer.

Lane.

Reaching. Maryland 20852.

rum.

'2mmnW

n

helmet! in 3.1 gram or huhhh whieh rcpt-«ant: a
at the tutorial and in the ongoing study of chronic:

Ethan:-

"KIWI

’is'nw‘

1”":

W1
‘

a

sample

habit};

mm

in Abbas.

The sample was brought back by
and we am sending
to you for

it
I
:30th
any.
would Wen“ your sanding thin totuuy and sending
and Fctmon.
to Drs.
copies of that
Dr. Dambmh

this we:

was: tho ten: of

"port

Thank you

for

my! Mao-.98.

8m

m coopmtian.

Simone-01y

yuan .

Mu Fink.

H.171.

momma 131mm:

mu

Ems.
em. to

Btmn ﬁlm.

24.13.

Robert Peta-sen.

241.13.

�</text>
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                    <text>TEE-529

Fcbmm 15th.

1973

Lemma 3. 1401:0101,

90:

Chaim.

W:

mar:

EEG

m m, “.13.
study program

-

$4.1).
6011133

”m

in human mmhophmolm”

31:10:94 am: «epics of mu

W

IND

umber: for

two

that I anticipate mums.“ this spring in the
"m in law plnhc’humolog’ﬁ

37/13

has .

studies

“W

�</text>
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                    <text>7383—3331

deruuny 15th,

1973

Alien A. Lucas, M:D..
Chief, International Retoronce center,
Psychopharuncology Rnloarch Brunoh,
Hstional Institute of Mantnl Health.
5660 Fishers L330.

Roekrillo. Hhrylaad

20852.

Dear Alieo,

nude

Ehclotod are two summaries of preaentnticno

at tha

matina

ABHP.

Khan next yen

for incluaian in the

that I

Payehopbnrmncology

are in the
I leak tbrvurd to seeing yuu. east. acne

and

visit us.

sincerely yours.

th Fink. M.D.

Praftlaer of Psychiagry
NP/iJ

WI;

�</text>
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                    <text>731-5321

m
mmmt
The

3wmtury.

2w.

rimmm

Dorm-wont mu!!!

hbmry

15th. 1973

Sylvan,

of moments .
Printing Office,

Vuhingtan, 33.0..

201502.

Dear 811-.

Wed

Want

Va "quest an
«any of the
Staff Manual,
Grants Administration. of the
a! Realm. Education
and Walton's, with such I‘upplmntu
my be applicable,

Wigwam t0

m.

W1:
u

are in newly: of Harm aunts and contracts for
research.
We

.

:

sincerely

yma ,

Mt: Fink,

MOD.

hawth- Director

war-w.

A.
0'

TJ'J’IIF“

"‘wuv‘Ti'Ivn

Elf/13

�</text>
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              <elementText elementTextId="54832">
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                    <text>7383-531

hbmry 15th ,
Dr. Donald A.

1973

Won,

6:- Stun-doe Avenue.

Rosetta,

Jobmnubwg.

Transvaal. 6mm: Airing.

.&lt;-‘

7-

wow”

wngr-

Tow

~14»

"WW”?"WF‘W

Dou- Doetor Simmons.

I m delighted that you will be 30111113 us and look
fawn-d t0 muting you about. Slat-eh 6th. Fret w diminutionwith Dr. Brinenden and Dr. Don, the various mangmnts
for your migration seem well in hand.

V,

v

t
,

I meant“

the highut priority must be given to
tha sustenance of your mum and we will do everything
we can to assist you. I believe ycur initial
will
be in conamction with our newly established
11:
drug shun. We will mango for some training and I
mtieiyuta that within I. run mum you will be «part
in the
or (mi-tea dependence.
than:

«31M
Wm

mmnt

I look {mud to meeting you aid your family. I trust
United stake: will In uneventful.

year flight to the

smears): your. .
fink, MID.
m
hotelier of Psychiatry

s

29/13

�</text>
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                  <elementText elementTextId="106591">
                    <text>“v-2uvmm—muqum—uu—w‘wvm

—-"'»’-'V"v.x -.—-w

x A.“

Win—- ant—w: *‘w'—r)——v\‘v‘irv’vv .vw.&lt;m._.—n.wW.—».w,....,.

731:057ct
February 15. 1973

ﬁr. Lawrence Erlbuum

v.3.

1511

Winston

3;

sum

I:

8921:,

AIM

washington, D.C.
Dear Mr.
12

Inc.

20005

Erlbtun,

8npgrutely, I an leading you the edited nunnscripts fbr
of the report: far 'The Psychobiclogy of ECT".

rnportl hava been retyped where the céiting vumld have
been difrieult fbr your typetcttcra ana eﬁitoru; in other cgaen, the
cditorial changes are nattd in rid. Twenthiras the eitttioal fbllow
one {brunt (Luther. Title. Jrl. vol, pp, year). but fear has. the
yn:r batvuen thy J21 tad vol. I hurt not changpd tat... lacving it
to ycur editor to make th: change: skillfully, tar uniformity.
Th0

I

haw! includoé the

originslo fur the figurnn. Platte
particulgrly I10 of Zarnotscr.

check the quality of theta promptly,

If thia

n—v-r—nmvr

"‘w¢wmw&lt;m&gt;

mHmw-rvum-mvrwr

'

shonla b. rcplsccd. please sdvicc.

I have an additiennl 6 docuaantn in hund which ruquir¢
either retypins, editing, or in on: cn30, in udditiunnl figure. Tags.
Inculd 10:3: my cfrieu within 10 d¢ys.

I have not indicated a zeqnnncc tar thn articles. I vill
lens: that to : unoting of its editors us soon u: :11 the nrticleu are
accepted, and the review: havn been digcotcd.

:“wm-v

You.vill not: thtt I hav. indicated thgt proof: are to
to the tuihors, the :cnior caitor fur «gob group; and. in addition,
I would.nppraciaz¢ n copy of :11 proof: so that I eta ¢oordiant¢ the
tart or ﬁrs. Hcsaugh and Keuy.
Thin should get us off to a good start.
go

sinccroly yours,

m“

‘rr'rv-

Max

cc: 6. Katy

J.

MCGtugh

Pink.

M.D.

.

w“

”

�</text>
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                    <text>“wry“

,wwmum.‘

mm»;-

newnv'WWV—r

-

'“WWI—rvvba‘lwr-

(r'

,

---.

r‘

.

,

--

,vry!

run-aw»

-":.;—.v-

v‘mrs'zc

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n

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«

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733:0hTorg
February 15. 1973

Prof. Dr.
Orgsnon

T? Vossenesr

Scientific

N.V. Orgenon

Development Group

Oss, Holland
Dear Jack,
few days to consider your kind invitation to
on
participate the Orgsnon anniversary meeting on October 27. I am
honored by the invitation and am pleased to accept.

I have taken a

the general framework of the meeting should
dictate the subject. Because I have recently been involved in three
issues of special interest to medical audiences, I can suggest three
The audience and

topics:

Strategies of
The

new

psychotropic drug development;

challenge of opiate abuse in America: Impact on

practice, politics

The psychobiology

and

psychiatry;

of convulsive therapies.

I have added a few notes about each separately
should be helpful.

is progressing well;
9h filing.
umentation for the
Our work

GB

My

best regards,

and

and

believe that these

I anticipate the doc-

and again my thanks

for your invitation.
Sincerely yours,
Mex

Fink,

M.D.

�</text>
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                    <text>73835354
February 15th. 1973
John

I.

Johnston,

Drug Alamo Informatics}: Programs,

Biological

Scum“ Communion macct,

The George Washington University Median; Center.
2891 3 331%”, HJL,
1)GC 20009.

Valium,
has:

Mr.

Johnston.

I think

mmlettor ”viewing- mgrm 1n
t aural aftert, and I m
plmud to assist you in any way that I can. If it is
not mom, 1% at least can be m, an! I wagon that
you try.
I an willing to contribute
. it you phrase
speciﬁc quantum.
a.

monthly

narcotic: antagonists would be

‘

A

mt:

an

0m 92 the things we}: I think would be useful in

mm
antagonists, their present experience.
motto
etc. A amend

only lune in

States using

o. 1131".

of the waters tn the

drugs used,
effort might be to as): ml:
of the people working with tho drugs to try to describe
15120

within
W]:
autumn“ are and.

narcotic

which they are working and how the

Please note the charm: in

wars”.
aineemly your: ,

Max

Fink, Md).

mresmr of Psychiatry
WI 13

�</text>
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                    <text>..........

TEE-5150

rdbruary 16th. 1973
Br. 3. Gardner.
Divisian or Neuropharmnaalogy,
rhea and Drug Administration,
5600 3ishors Luna.

Roakvillo, Muryiand 20852.
Dear Doctor Gardner,

thn pranent tins v0 are using cyclesocina at the
?.A. Rbspital in ﬁbrthyart in a study program of thc
narantia antagonists undnr RINK contract HEM ha-TE-lls.
A: part of tho trca$mnnt program. we are giving intrtwunous
attain 1n heroin chullonsna.
am

As you know these studies are derivative from the
axpcrienaca ya barn had at tn» new York Mbdicnl Collage.
ind eomylinent these studies. I do mat know which is
more expeditious ~ to amend the IRB for haroin at the
ﬂaw York undicul College to includc the V.A. anpital at
Horthport, or to amend the ayclazocine IE9 at Wbrthport
to incluae heroin far challenges.

Please navise and

‘vuuld be

cunnduant
Mhny

grateful

if either procedure is feasible. I

tccept this letter
if you wouldInn.

ta tho appropriate

as an

thunks.

lancerely yours,

was Fink. 1m.
Professor of Psychiatry

Mr/id

ae. to Alla

Btmncy. K;D.

�</text>
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73EB~5R10T

rubrunry 16th, 1973

ur.

Lawrunae Erlbcun,

7.3. Winston

1511

K

&amp;

Sons. 133..

street, 3.3..

Bashington. 9.0; 20905.
Dear ﬁr. Erlbaum,
Enaloaod in a draft «any a! yapcr 13 by Dornhush
tad Hilliauu tor tbs voluna 'Tha Payuhdbiolnsy at

ECT'.

ﬂinccraly ynurs,
“WV,“A‘

a.-.”

Fink. M.D.
Professor of Psychiatry

Mix

l._..r,.,_.._..,..,&lt;.

V:"’t.r)“

vaﬁu-v'lbrupv

"1"

m

vyﬁitn-

-

v-(mwm’xy-‘ru

W‘nmpy

rummvr

.mm.’lmyw”mw'm’“

MF/ia
Eno.

�</text>
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                    <text>738B~538

m
1a;
w.

,n

“mun

February 16th, 1973
Hrs. Lorrainn L‘aktr.
Research Grants Adminiltration,
New York Mbdical College,
106th 8t. and 5th Ave.,
Haw York, H.Y. 10029.

'

Wm;

2w.

V,‘v-

Dear Lorraine,

v
n

)uw—A-y-msq'wurr,m.v-

r.l?-"r.wm~

vn-z

I have Just rennivnd :nd read thc knnusl Rupert a: the
Renaurch Committee for the Farina chains June 30th, 1972.
This is an impresnivu daeument and reflects a great deal
of work, particularly on ynur part. Considering the severe
cutbaak in funds, the flat levnl sustaineé betvean 1969 and

is a credit to the faculty.

1972

r)

x want to thank you for making my aervige on tbs
research ecunitteo so ple;unnt. I take this opportunity
ta extend my rasignation. as I am now almost fullntime at

my new

vnnxuru.

Fw'bast regards.

slnaorely ynura,

his: Fink, 3.1).

Profnasor of Puyehiatry

NF/id

�</text>
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                    <text>A

,
.
A.»

.

deruary 16th,

2..

._,..

1973

.

,

.

1.,

4‘,

.

33,2

,.
.,

5.43,.»

Dr. Duvid Lchr,
anartaent of Pharmacology,
Haw York Medical Collage,
106th St. and 5th kvanun,
KW York, ELY. 10029.

57-1..

um

wac-

wu-uv-r.

r

navy.

ﬁscawesm-

wasvm'bﬁwm:

Dear David.

I have Just reoetvea and rend the Annual Royort or the
Resourch Committee for the yariod ending June 30th, 1972.
This is an impressive docungnt and reflecto a great deal
of warn, particularly on.your part. Conaiaering the severe
anﬁbnak in funds. tha flat lawal suatainad between 1969
and 1972 1: a credit to thn faculty.
I want to thank you for making IV sarvice on the
researeh cummittae so pleasant. I take this opportunity
to extend my reuignution. as I ta now uhwout fullntinn at

my haw

venture.

While

manna-r

:"rqugzemrgs-r-

.

it has

only been a raw yuara that I have untohcd

yum work ﬁl Chairman.

I

an aware of your yuonun cf!ort.,and
usubcr of the committee I am
adriee and leadership.

both as an invastigttor tad

grttotul for yuur hslp.
my

;

boat rasnrds.

lmv':§1ry;m§‘rtgaw;wﬂz

ﬁancercly youru.
mwmn.

mans-w.

Mn: 31nk. M.D.

Kenn)?

frets-tor of Psychiatry

in'w‘

.

59n-

33/13

�</text>
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                    <text>"W,

7.,

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vp.v_~7.gn—mw$r,pw,~

nun-n

‘

Dr. Joseph tunnels ,
of Pcyuhia’ery,

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University or

Powhatan
19195.

Philadelphin, Pu.

and. VA

19T3

Hospital,

Dar J00.

I have raviwed your rape“ 'Eleetmomulnivo
Therm and Sleep' which will be included in the
value ’The Mychobiolog of BOTH Largely a.
matter of style, I has" mm the liberty ofununs
some

small changes, and an melanin; an edited

maion of your "pm and a new mama-131:.
I trust this meets with your Approval. If than
are major changes. plum get than to as quickly.
If the changes are trivinl, plume wait for the galley.
Incidantnlly, tho delay in getting this report
difficulty in rimming a publisher who
wrmld meeet our critaria. of hot two and law price.
I am pleased to tell you that WE. Winston 8: 80m
«111 publish the valuma at a coat or $13.00 with a
cmplation in tins for the Mariam Psychological
out

was some

Mmhtion

1n Baptoabcr.

thank you for your

my”.
sine erely yours! ,,

Pink, Md).
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Mu:

30/1

Emu

thiatry

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                    <text>7%3—539A

Ibbruary 16th, 1973

Witt.

Gary H. Boyer, Chic!
Program ﬁwport section,
Center for {Studies or

Maﬁa

B

Dang Aha-c,

ﬁational Institute of Mbntal Health,
5600

Fishers Lane,

Roakvills, ﬂhryland

20852.

mm.m,

the Northport V.A. Hospital we now have five
pattonts on daily eyelasocine. we foresee that the present
suypliea will be exhausted. in about two weeks, and estimata
that by the lat March we will be using 5 x 120 cc yer watt.
M:

I

"writing 1m request an bottles (120 cc
#242415.
eyeluoclne under contract
am

If pouibla, this

m

should be shipped

Ed).
m
m.
mayor-taunt. of

mh) or

dirwtly to:

thiatry,

Bulletins 63.
Veterans Administration Hospital,
Harthport. NJ. 11768.

Attagtiom

Mn . Hurray

sincerely yours.

ﬁn: ﬁnk. 3m.
Profuse: of Psychiatry

”/13

cc. to Alan Runny.

14.1).

�</text>
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                    <text>'
-';

,m-

w

~

‘
-

«WIN

2hh7

"'1’

?3SB~550A
www-mvwawv—u

February 26th, 1973

,-q_‘p3‘-“rgnwu‘gﬁfwwzﬂqu""u‘iﬁn‘ziw'ul

Br. Pater Riedesaor,
Psychiaﬁriaehe und quvmn-Klinik
der Universitit Froiburs,
18 Freihurg im Braisggu. din,
Eauptstraﬁe 5.
Germany

”ﬁrm",

Duar Banter Biedeaacr.

'3?-

Enalancd

vv‘rw-mhrv-yﬂrsswzww.

zgaﬁi'vdw

',n
I“

fawn-'3‘

'.

is

a summary rapart an tha narcotic

tntagon1nta which I eomgletod 1n saptudbor far the national
Caumicsion on marijuana and Drug Abuse. (Because of the
dupliattinn costs I wbuld nyprectate your sending a chnek

in the

amount

of twanty (26) murkn).

This report is comylete up to Septumbcr and
have a» additional information since then.

V»

With regard ta the aamplia:tions or methadone. I
th§t
suggest
you ice tho latent lain. of the Archtvna of
Gonorul Psyuhintry, vb!!! there is a fine srtielo by
Jasinaky, ﬂirtin and thuir coworktra on the pharmacology
of mnthadono. Quotations tram this urtiele should suffice
83 31?: the ru‘dar 1 «lair picturt it tho rink. and bonafita or

methndanc use.

'n‘rmcr

WV!"

’WTKJ‘H'H'L?

Plunso note thn change of my addross. I lack
rbrvurd to reading a copy of your aynoyaia as soon ta it

uvuildbla.

5!”

ﬂincerely yours.

j'wlwﬁ‘,

.,

m: rink,

14.9.

Professor of Puyehiatry
MF/iJ

WI.

is

�</text>
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                    <text>F‘

ZhhT

ESE—Swan

Febrmry 26th, 1973

mun“,

are:

Leonard E.

mom:

m Fink, $1.1).

8W:

003138

Boa-mu of

to “tuna the

is

some

54.13.

mating

(tonaittmnt. I will not be able
t pﬂor
mounting on Ehrch 7th. I! there

CORIHB

intomt-ion that I «:1 supply prior to the

mtinqunbegladtodow.

WI 1.1

�</text>
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73$B*5h3A

February 26th . 1973

Alta Runny, Md)”
medical

mutant,

(:11an Drug Studs.”

Canter for Maudie;

Section,

or Eutectic and

Drug Abuse,

anticml Institute of hunts]. Health.

5606 Fisher: Lam,
Rock's-111.,

mama 20852.

Dona-Alan,
The work at
mart haw to

is going Quite well. we have taught
the
ayalmcine and nethadona.
the use or harem challenges. aha-um the program: continues: ,
the

VA

must“

m

be able to assign patina on an alternate but: to
amimoina
and methadone within the next
weeks.
V111

6—8

This study was awn-d by tha human Adainiatmtion
on November 6th, 1972. A copy or that approval is enclosed
for your ﬁler, as in a. copy at our permit. Amara“).

m
a unwind in the contract proposal
I look inward to having yen and Steve 8m with
at your comninncu.
grim for the study
“hunted to HIM.

mama-013'

Mu:

Fink,

ymra .

11.13.

Frofeam of Paychntry
20/15
M: .

�</text>
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                    <text>7383.- 5518.3

robmry 26th.
To:

shotgun E. Kiutfur, E.D.

FROM:

Max

SUBJECT:

Dr. Eugene L. Lawlnkopf

I

Fink,

1973

M.D.

met Dr. Lowonkoyt

first

when he anus

to

30v York

Radical Cell-so in Hiy'ot 1966. It was clear than, and his
aubauqnant history cantirms, tbs: he is a clinician of «Virago
experience, without particular akilia in adulaiatration,
roaanrch, or teaching. He was t pleasant young man vho
left 32MB Vina faced with the rigors of participating in
controlled aamparisonn of drugs in the outpatient department.
He chose to laavo RYMC rather than wart through a more
satitfhntory working relationship. (I may be doing him nn
inJustice, far I understood than that the Bronx manicipal
was racruiting actively, and thay muy haw» offered hiu a

better position).

I can not see him an an motive participant in any
or the ongoing programs. fbr he in too advanced in yeﬁra ta be
a staff maﬁbcr at the VA or CI; nor does ha haw. enough
taperiancc to sue him an an independent teacher. cansultnnt,
or rtstaroher.

I an.uchadnled ta

Lona Iulnnd

NF/id

university.

31v: a caning: on Mhreh 20th nﬁ
sud can not meet Gene here.

�</text>
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                    <text>w

wen-"11.:

“war

W:-

umz‘

»

2M7
7383-63783
relax-nary 26th, 1973

Dr. Ellen Orin.
Department of

thiatry.

University of Unitarian, School or
The Canter for tho Health Seances .
Io: A1391“. California 90023:.
Dear Doctor

mum,

Grits,

M: the present time April and ma 39d are both open
and I will be glad to sea
If you will dascribe the
causation: which you would like to have wavered I «I:
make the
either in Kw Kerk city or at
Stony Brook.

NW:

m.

You may be particularly intmated in a.
tux-mind by Columbia. University an Wednesday,

senior:

April Mia
and! Thursday. April 5th on the subject "Drug abuse:
amount and Paychotomimica" which is being unwind

by Dr. Luce Bimpaon of the Department of
$33.8.

mmcolog

I look tome! to swing you.
Sincerely yours .

Mt: Pink. ”and

Protcumr of Psychiatry

19/13

gt

�</text>
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                    <text>jpzxahhT

7383-536A

Ftbruary 26th. 1973
338‘ Bupartmgnt 9! Justice
Bureau of Eareotian and Dungeruu: Drugs.
F. O. Box 28083,

Central Station,
ﬁhshingten, D.C. 20005.
Gentlunnn.

Enclotod in an nppliestion for resiutration as
renuarcher fbr sehcaule I drugs.

as the present time an are operating under a
contract sth2-72~115 with RINK for the study of unreatic
antagonists; sad huve aslunmd responsibility for the
VA Drug Khan. Treaknenb Center at Horthport VA Hospital.
In thin program, supported both by the MIME and VA. W!

art

u$11151n5 mathndono, lavonathndyl, eyelaxocine,
naloxnne. unlorphinn and heroin. A eopy or the contract
proposal is enclosod.

Sincerely yours,

ﬂux Fink. M.D.

Professor
MrliJ
Hines b

at Psychiatry

�</text>
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                    <text>7383~562SB

March
'rr‘

.
3..

”mgr-“w“

5th,

1973

Miurice R. argon. M.D.,
151 East 83ré 8t..
Rev York. N.Y. 10028.
Dear usury,

;
E

%

E

3

It was indaad a pleasura to hear tram you. Aline aha
Hurtin Joined my tunily tkiing 1n Vila. Eb had a fine tins.
Evan Alice got on skin, ana considering her phobic snxioty
dbout any harm that may cann to hay anklea, her willingnest
to try was nymbclic either of a raduction in fear. or In
assumption that her dancing was last important now than 1t
had bean than: unny yearn.
At

E

;
g
‘

g
%

tbs

pwﬁlemt time

SUNY

at stony

Brook does not hava

both be appointed.

It was sped hearing
W but regard- .

a":

-v.'r,

gnu

"v7.

from you.

‘WV'M‘H‘

sinceraly ynurs,

m7“

wr-ag-rv

-

«syn-«m,»

3-

Nb: Fink, M.D.

7w-

Protester of Psyuhiatry

:(—:

~

I'mvy"'&lt;:

6
$’Y5"-J/'

'fxu

ﬁ,‘
w
:-

nvrm-rqv—

«.u

"mm-v;

'l-rmn‘rr-Wn'

r

mwrmﬂ"

1t-

hospital and is dapundent an the elinieul faculties of the
v.1. ﬁosyital, meadowbrook, Long Islnnd Jewish Hoayitul, und
Central 1:11p. I do not think the opportunity for a part~
tint positicn at the univarsity is too good. my expectution
is that within a few years, when the clinical center at the
univursity is finally completed, clinical fund; will be
tvnildbla and a faculty, both partutimm and fu11~t1nm will

awn

Ml/iﬁ

�</text>
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                    <text>.
..-,—A

vrm-4-u._

.mnr.

7383-425

June

Gnu mtrmnt

21-15 .

1973

Gm.

101 014 Colony Ave. .

Quincy. than. 02169.

Attn: Mn.
Dear

man Gnu

mm.

Enclosed in a. 1mm drive from ‘ h channel
tantrum-n1; men I pus-chant! sou your: use. the

clutch

11190 no

uncanny. I

or

um w rm

would be

"plain; this unit.
Plano

mm

1%

to moving
mu
not
either
”paring
mum.

to n.

ct

the

a:

thum.

Health Batman Cantor,
am at many Brook.
Stony Brook.

NJ.

11790.

Bimcrdy your: .

ﬂux Fink, 31.1).

manor
Ill/1.1

,

of Psychiatry

�</text>
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8th.

1972

Senator Harri-on Goldin.

1020 Grand Concoursa,

Bronx, 3.1.

thSl.

Dear Senator Goldin.

It was

a pleasure to talk to you this morning,
enclosing a suumgry of the available «Vienna:
for tha clinical use or the narcotic antagonists in
apiate dependunee. This report has been submitted to
the Marijuana Commission and will be published as
part of their report ta the Presidant next spring.
and

I

am

8hou1d_you wish additional information, we would
be pleased to meet vith you. The principal center
vhare this work has been done in the New York area
‘13 the Metropolitan Hospital Mbntal Health Center,
whats there are many patientu in different stages of

treatmant.

Sincerely yours,

Fink. M.D.
Professor of Psychiatry
max

MF/id
Eng.

�</text>
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                    <text>7333.673
May

17th.

1973

Alan Giles, 24.12..

Scientific Devolupmxxt Group,
Drama.

H. V.

0". 301m.

mum.
n

,

.

Jae-F127,");

wavy,

«ma

‘1‘

-.
Aw

"7"WWTHF'I

n"

I' an schedulcd to
of June and an KL 6%.

mks a

in Amatordam on the morning
win
I would, thou-atom, ask you to

rumution at the M1291 mama for

Me

«r
law

Saturdny.

Our a.
June 2nd. and to
to meet this flight
morning. It in ccheduled to arrive at
on
Amsterdam for Athm
10.00 am. I m ”hauled to
on the 11.00 am. ﬂight on Tuesday, June 51:13. It
might be useful for no to
to Avatar-dun on the
Monday mains. June hth.

sum

ntm

m

In addition to mating with Professor Von-cam

Dr. Sapilrosel, I should like to spend some time
mm Hank van Riexen. I ahaum like to revisit tho

am with um um I sun
ot'om‘ mating. in your hands.
01—63

luv. the «mamas

I look forward to seeing you.
W

but

regard: ,

Sincerely yours.

Fink, 1M).
Professor of Psychiatry
Max

nil/13

�</text>
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                    <text>J?x
:1.

,—.

-

.&lt;‘__A‘._.‘.“_,,.,.H,aw:u.~.

Daaeﬁbor 18th, 1972
sumnol Gershon, M.D.,

Professor-er Psych1atry.

Yark University School of Medicine,
Ave. and 30$h,8treet.
New York City, E.Y.’
New

First

Dear 8am.
on

I vauld very much appreciate a preprint 0! tbs report
the thnbaine analog which was submitted for publ1aation

to Jon Cole.

_

As soon as I have re¢§1ved response from Al “Eismam
or anothar pharmacologist, will lat you know about the
EGDEU meeting.

I

Sinceraly yours,

Fink, M.D.
Professor of Psychiatry
Max

Mf/ia

�</text>
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                    <text>aha?

TBSB¢55hCT

deruary 27th,

1973

Dr. 0. Gardou,
Ecsten State anpttal.
Boston. Haas. caleh.
Boar George,
Enclosed is a ravinad nnd updated uunnnry
high and low data thiothixenc data.

at an:

fan will $93311 that same vast: ago you asked thy
ant: be rcanalyscd using differant nah-eta, as you noted
thtt name patient: had not been assigned to the

apvropriate groupn‘ 'This has bean done. Again um find

thst tha high dose graup has t signifiaunt change which
as: be ascrdbad to the drug offaat. but that no differenean
oeeurrcd bckwaon the high and low dose groups.
Again,

I wuula b. pleased to

of this data with

it.

my

yum

nttcr you havu

go ova:

tha interpretation
ta diseat

had a chance

beat regnrds.
Sincerely yours.

'Hux

rink. 3.».

Prafanuor or Payehia$ry

50""

ymﬁ‘gw

ur/ia

“3.
cc. Dr. J.

Cole

�</text>
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                    <text>731~5520T

deruury 27th,

1973

nr. Lawrence Errbaum.
7.3. Winston &amp; Bonn, 133..

Street,

1511

K

DC”

263'.

K.W.,

ﬂushington, 3.6. 20005.

Militia,

Enclooad
13.
15.
16.
At

tr:

payura lhulﬁ:

Jan~0tto Ottalaon
Richard Ebramu

L.

Valaalli

this time yea lack four reports
to yuu shortly.

thnﬁ these get

and

I will sou

sinnercly yours,

Pink. H.D.
Professor of Payahiatry
Mix

HF/iJ

may

�</text>
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                    <text>zhh?

tsan~55acw
February 27th. 1973
Dr. A. G. theznnr.
Depurtnent of Phtrneealogy and

Instituxe for

Mind, Drugs and Behavior.

W. Illinois

bowel; Uhivernity Medical Center,
60153.

Deer Alex.
we have had tun reviewers reed your report "Bruin
Acetyleholine and auteuree“ which you submitted for the
EC? volume. he yen know, the substance or the report is

ingortent

end

of great interest.

The

presentation was

diffieult to fellow however. since the written text
lean: to fellow the verbal presentation. Lacking your
chility tO'emphasize, we have fbund it difficult to
fellow, and have taken the liberty of making some suggested
changes. I have bed the text retyped and enclose your

meet

eriginel edited copy and two xerox copies of the retyped
I would be most grateful if yen venld reed

vernion.

thin promptly and make such eorreetione as
return it to me within ten days?

Gen you
my

you may wish.

best regards.
Sincerely yeure,

ﬂux Fink, M.D.

Profeeeor of Paychieery

hilt:

“.0
cc. to Dr.

8. Katy

�</text>
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                    <text>QWW

Win-q“.

Tut”

'r'

,_‘

.

myr-pi‘.,vvr.,..«v;V.r.,‘,

K
731:0}1l

February 27. 1973
Herbert Haber
Paneth, Haber &amp; Zimmerman
150 East 58 Street
New York City 10022

Mr.

Dear Herb.
The enclosed request from the IRS for an explanation for
lete—filing of the 990, end the penalty, requires your masterful

hand.

,

Many

thanks.
Sincerely yours,

'ww'n-W

.72"

an

w-wrv

"waﬂr‘wm-min2w9wmm‘”

"

iltmzLW'mAm-w~

WF'WR“

J-n

&gt;5va2m1u

Mex

Pink.

M.D.

�</text>
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                    <text>December 1, 1972

George Gardos, M.D.

The Commonwealth of Massachusetts

Department of Mental Health
Boston State Hospital
Boston, Massachusetts 02124

Dear George:
my

I have received your letter of sovember 21. I am moving
laboratory this week and cannot get to the reanalyses until

the second week of December.

you

We will try to accomplish
at that time.

it

then and get tne results to

Sincerely yours,
ﬂax Fink, M.D.

Professor of Psychiatry
Ming

�</text>
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                    <text>December 4, 1972

92

Dr. Hanus Gﬁosz

Department of Psychiatry
University of Indiana School of Medicine
Indianapolis, Indiana
Dear Eianus :

ulate

I found the session

by the

stimulating, and congrathope you will not be intimidated
difficulties and proceed with your studies.
Wednesday most

you on your enthusiasm.

administrative

I

Your reception by Dr. McGlaughliu was most cordial, and I
an confident that they will support your work if they can.

I did not offer to undertake the heroin challenges, because
my laboratories from the city and now lack facilities
to do studies of Opiate antagonists. (One factor in my decision
was the prolonged arguments this work engendered « work which arouses
passions, and makes sensible men intemperate).
I

am

moving

direct assessment of the
associates will assist you

Should you wish to undertake the

narcotic antagonism of prepranolol,
in any way they can.

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>Dcennbor 4. 1972

9m.“

1’.

Klein, :40”.

Hillside Hospital
P.0.

Box 38

Glen Oaks, Riv York
Dear Eon:

In packing my-books in ﬁg» York I came across copies of this
document ~ dcscribing our scope prograaa for psychiatric diagnosis
based on Diagno—II. I cannot recall tending out to you before, and

‘0 send this

now ~ yarhapa

it will uscful

to your team.

Sincerely yours,
aux Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>necember A, 1972

Jaw/M0,

(2&amp;3)

léé-S

Geoffrey woodard, Ph.D.
Pharmacologiat
Uoodard Research Corporation
12310 Pinecreat Road
Herndon, Virginia 22070

Dear Dr. Woodard:
While I believo the City of Rev York will eventually honor
seemed prudent to avail ourselves of the good offices
~ with the hope that they will, either by the majesty of
of
their office or by direct support, gain reimbursement for your efforts.
I have called Dr. Alan Green of SADDAP and asked him to advise ua
as to what they can or may wish to do to aeeitt no in making your
data available for an IND filing.

its contract, it
SADDAP

I anticipate receipt of the report you sent recently. Mean~
while, in anticipation that Mr. Heet canvsupply the documents that
the City, through ite agent Mr. Jacobo, uiehes nrior to payment,
I would ask that these be supplied directly to our fiscal officer,
tire. Waldov.

I

an

optimistic that theae issues will be resolved,

forward to testing diprenorphine in man.
Many

thanks for your

efforts.
Sincerely yours,
Mex

Fink ,

31.13.

Professor of Psychiatry

Ming
cc:

Alan Green,

SAODAP

George Jacobs, REC-NYC
Hrs. L. Haldov, NYMC

and look

�</text>
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                    <text>i
e...-

E

secember 5, 1972

Mary McClaughlin, M.D.

Commissioner of Health
125 North

noom 604
New

York,

Street

New

York

Dear Dr. HcGlaughlin;

I want to express my appreciation for the opportunity to
participate in the seminar on the possible role of propranolol in

narcotic addiction.

ine session

Yr“!

was most

interesting

and

useful.

While we would be pleased to undertake a direct test of the
narcotic antagonism of propranolol with heroin “challenges“, you
should know that we have been enjoined from further research studies
at Aetropolitan Hospital, and until'we relocate our laboratories,
this interesting study will be deferred.
we have had difficulty in obtaining payment
animal
for the
toxicology studies of diprenorphine (J~5050), which
we undertook in good faith in Hatch 1972. The assays are almost
complete, lacking only the final review of the histological slides.
Hr. Jacobs of your staff has been most helpful, and regretfully tells
us that reimbursement can only be provided on completion and filing
of the report (the “product”), and its approval by agencies of the
City. I have communicated this to Dr. Woodard, the subcontractor,
and it is difficult for him to accept such an interpretation of the
contract. As a small business, he feels that he is in some diffi—
culty, lacking any payments during the course of the work.

Parenthetically,

Perhaps, you can exert your good offices to assist Hr. Jacobs
in gaining the necessary approvals for the statements already submitted.

�December 5, 1972

Mary HcGlaughlin, M.D.

Because the subcontractor has expreseed his needs so force~
also sought the aséistance and advice of SAQDAP, on
fully,
the assumption that these data, once in the public domain, will ex—
pedite the filing of an IND, and the testing of diprenorphine (H~5050).
we have

Again,

ticipation in

my

thanks for you consideration in inviting

a most

interesting session.

Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

31'!"

2

if,

my

par«

�</text>
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                    <text>'r
94.2.;

’

December 5, 1972

Jonathan 0. Cole,
Superintendent

M.D.

The Commonwealth of Massachusetts

Department of Mental Health
boston State Hospital

soston, massachusetts 02124
Dear Jon;

I read the ”Effects of Acute Administration of Papaverine
the EEG and Behavior of the Normal Geriatric” with interest.
findings are consistent with the prevailing hypotheses relating
change and behavior.

dCL on

The

LEG

The discussion focusaes on the issues that I would raise:
the selection of subjects and the drug dosage. The study should
be continued in elderly subjects with EEG evidence of decompensation.
Ihe dosage issue is also critical, and a dose finding study would
be useful, using progressively higher doses in pairs of subjects
until EEG evidence of change is clearly evident or behavioral tox—

icity limits further trials. (Now that our EEG profiling methods,
the recording and analyses, are standardized, the dose finding has
become the most difficult part of our studies).
text leaves a

battery of
significant time Span. When are
the behavioral tests done, in relation to the EEG, and in relation

tests is

The

few

questions unanswered.

large and must occupy a

to the drug ingestion?

How

long an

EEG

sample

The

is taken?

The hypothesis anticipates a change in mean alpha frequency,
abundance
(amount). It is possible for the amount of 8~9 cps
not
be
reduced, and 10-11 cps to increase, and yet, the total alpha
to

not exhibit much change. Indeed, this is not infrequent ~ we have
reported this type of change with cannabis, and others have noted
similar effects in cats with psychotropic drugs. It may be appro«
priate to undertake a ”narrow band” analysis, i;g., reanalyze the
records filtering first so that activity below 5 cps and above 13
(15) ops is suppressed, and then measure the changes in l—cycle band
widths from 6 to 13 cps:

�'T

December 5, 1972

Jonathan 0. Cole, M.D.

were unaffected, it is conchanges minimal. The task remains, to define
the central effects of papaverine, and both dosage, time, and sub—
jects may have to be varied to achieve the result, or to state that

Finally, since behavioral tasks

sistent to find the
CNS

EEG

effects are not significant.

George Gardos has sent us a restatement of the times and
dosages of the subjects in the thiothixene study, requesting a reanalysis. We will rerun the analyses as soon as I am able the
equipment is moving this week and it may be some time until we are
—

able to get to this work.

I look forward to seeing you in San Juan.
Sincerely yours,
Max

Fink, M.D.

Professor of Psydhiatry
iF:gg

�</text>
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                    <text>December 6, 1972

EEEQBAEREE
TO:

I.

FROM:

Max

SUBJECT:

Equipment at Wetropolitan HOSpital,
5 East 102nd Street.

B. Schwartz

Fink

All equipment listed

was bought by

NYMC

Antagonist Study) and is so labelled.

under

to

NH

he moved to

12567

(Narcotic
Total

To 102

8

5

1

1

18

10

3

1

3
1

1

1

sides)
single pedestal)

Desks (brown top, black

(each 30 x 60,

Desk

Brown “wood", double ped.

—

Chairs

w

Black naugahyde, some with arms,

S one

s t raigh t

Colored (red, orange, white)
Executive chair, brown

-

Chemical lab (green)
Cabinets ~ (black or grey 5-6
Desk

(
'

Table ”wood top”
Shelving units
—

ft.)

10

File cabinets

It is

my

1

3

0
3
1

that the number on the right be released
East 102nd Street as soon as practicable. Nurse

recommendation

for transfer to

5

Sonna Durbin has made the inventory and can act as liaison
identifying units to be moved, storing contents, etc.
The

3
1

shelving contains

EEG

These should be moved to

5

for transfer,

records from the psychopharmacology studies.
East 102nd Street as well.

�</text>
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              <elementText elementTextId="54512">
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              <elementText elementTextId="54513">
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                    <text>Dsocuber

8th,

1972

Arik Brisssnasn. K.D.

Chief, Psychistry Ssrvice.
Vitersns Administration Hospital,

Earthm. Lats;

HJ'. 11753.

Dear Arik,
With rogsrd

to

Andy Don,

yaur

letter of

Bovuﬂbsr 28th

is sass;lsnt. I belies! you should appoint Andy tron V.A.
funds for two half dsys par V‘Okllll, and when wo has. s full

tins psynhistrise ta

nonlﬁor tbs program, we snticipato

transferring his to other funds.

Sincerely'yours.

Mb:

Fink, K.D.

Protsssor of Psyﬁhdstry
“1/13
30. W. as

net!”

�</text>
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                    <text>‘\

»

December 11th, 1972
hire. 0. (Manor .‘

Personnel Officer.
Surge E.

Rm. 1&amp;9.

Dear Mrs. Gwinner;

I an in the prooesa of moving a study program from the
to the Health.8oiences Center. As

Kev York medical College

part of this program we already have received support (Antagonists
to Opiates, Knuth2e72~115). Under this oontract I have
recommended for appointment three young research aasistants:
Peter Irwin
Carolyn Poinier

Ira Snapper

of the principal ingredients in Obtaining the
nonperation of these young people in working at Stony Brook
has been the opportunity to participate in the teaching programs
of the university.
One

I have been asked by them today whether they can obtain a
temporary identification card so that they can meet the requirements to register for courses for the next semester. It is my
understanding that such an ID aunt he in hand before December lhth.

7

I have recommended thsle three young persons for appointment
to the Foundation; their papers are in process; and funds are
available. I would be grateful if you could provide any assistants
with the nsoessary temporary documents to permit than to
participate actively in the edunational and cultural activities
of the university.
I en indeed grateful for your cooPeration.

‘

Sincerely yburs,

Fink, M.D.
Professor of Psychiatry
Max

Approved:

Mllid
no. to David Pappalerdo

Stanley F. Yolles, M.D.
Chairman and Professor

�</text>
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                    <text>December 18th, 19??

Hikler,

Abraham

M.D.,

Professor of Psychiatry,
University of Kentucky Schocl of Medicine,
Lexington, Kentucky.
Dear Abe,

I very much enjoyed our dinner in'ssn Juan. I was
inspired to plan the volume reporting the text or ynur
earlier hypothesis, and indeed, apant-Most or Friday
writing the outlina. I also spant a good deal'of time
discussing ﬁiﬂh A1 and Dick Raunick the steps necessary to
taut the extinction hypothesis. I hope I can stimulate
this staff at the Rev York Medical College to undnrtake
'

this study;
I

ma copies
and
thn
meeting
at the
antagonist
a! your prementaxion at
am

ACNP o

writing t9 ask whether you would send
‘

‘

I am enclosing a tau reports
laboratory that ralste to tho EEG program.
_

Meanwhile,
My

from my

best regards.
Sincerely yours,

Fink, M.D.
Prefenuor of Psychiatry
M33

HF/id

East.

�</text>
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                    <text>u:
:va

v

:xww-o

r

"wrung-raw)?

Deceabor 18th, 1972
David Tudeachi, Ph.D..

Department of Pharmacology,

Lederle Liberatorias,
Pearl River, n.2, 10965;
'

Dear Bava,

Following cur diseunsion,1n San Juan,

liberty of enclosing a summary'report

I

am

taking the

a

from 1969 and

'

recent report of our studies using the EEG profiling
in potential paychoactiva drugs. You will find aimilar
report: written by Itil.

more

'

I trust this 1: hﬁlpfulh

runa-

my
yn-:mm:a~..n-wm

‘

I

beat regards.
Eincerely yours,

r

ﬂax Fink, M.D.
Frofoaaor of Psychiatry

MF/id
Enc a

�</text>
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                    <text>7383535~A

Fibrunry 15th. 1973
Joan

!.

Johnston,

Drug Abuma Information Programn.

Biologictl acionecs Conunniaation Proacct,

The George thhingtan university Mbdical Center,
2001 S attest, N.W..
Wishington. D.C. 20009.

ur. Johnston.

Dear

I think a monthly newsletter reviewing programs in
narcotic antnsonists unuld be a utufnl effort, and I am
pleasud to anniot you in any way that I can. If it is
not useful, it at leant can be fun, and I suggest that

you

try.

I an willing to contribute enmnantu. if
spacitic quantions.

you phrase

one of the things whiah I think eould be useful in
an early taunt in a 113% a: the ecntcrs in the United

status using narcctie an§nganints. their present axporicnae,
drugs used, etc. A ao¢ond attort might be to ask each
at the people working with tbs drugs to try to duaerfbo

tho {runawork within which they
naruotic nntugonista are used.

tr! working and how the

?10Ile note the «hang: in nderSa.
ginncrcly yours.

an; 31nk,

M.D.

Profbssor of Psychiatry
Hilid

�</text>
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                    <text>Deceﬁber 13th, 1972
Donald Jenden, M.D.,

Department of Pharmacology,
University of California,
Los Angeles, California.
Dear Don,

I very much enjoyed our discussion in San Juan.
Should the Opportunity arise, I lock forward to greeting
you in New York, and will try to visit your laboratories
as soon as I am able.
'

I

am

enclosing a few reprints which describe our

point of View with regard to ECT, and a preprint of a
summary of our work in EEG profile analysis.
The naw methods whiah you described for the measurement
much more exaat than anything we

of acetylcholine seem so

have had before,

that their agplieation to the

should be most rewarding.
my

EC?

problem

best regarﬂs.
sincerely yours,
Fink. “GD.
m
Prafassor of Psyehiutry

mu
Ema.

�</text>
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                    <text>A-vwv-M-ug

MIL—.m-

‘
December 18th, 1972
To:

Dru. Leroy Brown and Stnvan Hbiabroth

FROM:

Max

SUBJECT:

Fink,

%.D.

Attached application

I

would uppreciaﬁa your review at this application,
reaaarch snaistant, Miss Carolyn w. ?oiniar, who fulfills

for
the rearuitmgnt requirements, inscfar as she 13‘;

MF/iJ
Ema.

woman.

�</text>
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                    <text>December 18th , 1972

Mrs. P.

T0:-

Max

FROM:

summer:

Commerce

Fink, mu.

Recruitment

0: Ensure}: Assistant

.. 1800 Programmer

pm

of an: program 'Antagonists to Ogiatas' we
EEG records from the patients at the
collecting
anticipate
VJ». Kospital beginning mid January. In preparation for the
analyses of these records, I should like ta find. a
Research Assistant, 3.800 Framer who fulfills the
requirements , particularly the experience requirements. at this
position.
As

X would be
grateful for any ansistmee you can give
in recruiting candidates, because tha program will begin

opcrution about. January 15th.

ac. to Mrs. 0. (Winner
ids/13

Em.

‘

t

k":r‘~«"-

4'“

Tik’prﬁlu‘I‘lt’iﬁ‘H‘74T-ﬁw"Le/"*1

Dr. Leroy Brown
Dr. Steven Vaiabroth

me

�</text>
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                    <text>December 18th, 1972

Professor

Chairman,

J. Caﬂhilhae.
Institut dc 81019319.

Faculte ﬁe Hadeclne,
Bh-Mbntpcllier, Frango.

Dear Professor Cadhilhac,

I should like ta present ; scientific exhibit at the
intarnutional EEG meetings in Marseille. The aubJact:
Drugs, 3355 and thavior. I am preparing a panel display
with a slide proaaetor dnmnnatration which will run
antamatlcally. Because the text will be recorded on tape,
1t_vauld be possible to record the same text in French and
German aa-wull as English. We will mead a space of 16' x 6'
1973

_

or

its equivalant.
I

am

.
.

pleased to enclose an abstract for your consideration.
ﬂineercly yours,

Fink, M.D.
Professor of Psychiatry
Mn:

M?/1J
Eric.

�</text>
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                    <text>Kovcmbor 213%, 1972

HI. Diane Johnson, 8.3.
337 Whterside Ave.,

Horthport; H.Y.

Dear Mh‘ Johnson,

I have finally checked with the V.A. and I vunld
uypreeiate your completing the enclosed form of
:pplication. Please return it ta me at Stony Brook, and
as soon an

I have

it

I will process this.

Thank you.

sincerely ycurs,

M3: Fink, M.D.
'Profeasor of Psychiatry

MF/ia
Rue.

�</text>
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                    <text>December 19th. 19??

Dr. William Martin,

Director, ﬁational Institute for

Mbntal

Health Aadiction Research Center,
aexington, Kentucky.
Dear
mm;

mm“

v
"n“

'«w-ﬁmu

re
.«1‘:

9w-

m-wm‘nm“

mpavaah'mrwmzwz:

1-,“:

oﬁn’;

Bill,

'Last year I was invitad £0 lectura in Europe on
aur experiencea with the narcotic antagonists. After
I had indicated the need far longer lasting ana pure
narcotic antagonists, the vicenprasiﬁent 0t M.V. Organon
sent ma the analoseﬁ memorandum on a compound

n—cyclepropylmethylnoroxycoﬁone hydrdbromide (0130).
After raading thia documant I was imyresaed that the
compound

warranted further atuay. In seeking the

as

(3138050) and was presented

aubmissiona
UMkT3

The

the

I

found

presentation
compound

I

is

13

that this

campound had been

in the

HBO

tented

196k meeting.

ﬁnadequate, but the data suggests

long noting and an antagonist.

to advisa them
along the proper steps to ba takan to furthar develop

this

havn bean asked by H.V. Organon

compound.

gm,

w

,‘II'I'I-t‘

"m:

:-.-g=,-,-s-gpvw:qnmw

1»),-

Wm?

Ordinarily. I would havu hesitated procaeding further,
but 1n‘raading your report on naitrexone I have become

that this aanpound may alsa exhibit some of the
nannistia features which hays tended ta discredit

anxious

cycluaoeine.

I vauld appreeiaze

your sdvica as ta whether 0130
warrant: turthar investigntion. All the awaildblc data
is in the enclosed manorandum. Further study would
raquire animal toxicology similar to thong undertaken for
diprcnorphine and it ”clean" furtbgr human touting.
unfbrtunately H.V. Organon does not hold the patent for this
formulation gnd tharefbre, their principal interest is in
contributing to our information. I believu they vauld
make the cumpound awnilable and vould cooperate to the
artent practicable should.vn encourage it.

�Dr. William martin

I

~2—

December 19kt. 1972

would ask that you keep the information confidential
until I have had an opportunity to discuss
with you.
I would bo grateful if you would take the time to advise
us. for I know of no—one else whose View of the narcotic

it

antagonists in so clear.

year.

my

very best wishes for a auocosnful and happy
Sincerely yours,

Mo: Fink, M.D.
Professor of Psychiatry

MF/ 1;;

new

�</text>
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                    <text>December 19t3, 1972
Anthony Novels, M.D..
Biological ResearCh Section.

Clinical Research Branch,

Rational Institute of Mental Health,
5600 Fishers Lane,
Rookville, Maryland 20852.
Dear Doctor Howels,

I am pleased to enclose a number of reports, both
publiahad and in press. which have been accomplished
under ME 15561. work under'this grant is continuing in
writing up the CS? findings and preparing some studies
with Dr. Whiter Seaman of CUNY in Queens College.
The terminal report and additional reprints will be
submitted as soon as the ongoing summaries are completed.

Sincerely yours,

Fink, M.D.
Professor of Paynhiatry

Mix

MF/id

Enos.

�</text>
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                    <text>Dualibcr 19th, 1972
Benjamin 3. Hblnnn, K.D.,
66 strum , Suite 613.
just
new York. H.Y. 10023.
.10

Dm-

mm aroma,
Thank

in“ very

'mxozpuc
m m- 1.th aaf‘nnntal
disorders.

in your hsnabook tor trontnnnt

mothodn

ma

I regret that I an andble to cut aside the tins at
yrcoont to andcrtake such a sun—pry. abould the finlncial
_arrtngunonsl for such a yorticipatian ha significant, I
vauld be glad to reeaunond nun of my associates whoa I
bclieva is capdble of doing the 36b. 1 would hesitnto to
nth hia unlois I warn dbl: to compensate htm for the
tin. involved, sine. ha docs haw. a practice.
Sincerely yourt.

ﬁnk, 24.».
m
Professor of Paychiatry
HiliJ

�</text>
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                    <text>rn‘ﬂr-n—‘J

m

December 22nd, 1972

Ins-"nu

Mr. Thomas Crook.

Payohopharmocology Ecsoaroh Branoh,

Rational Institute of montal Hoalth,
5600 Fishers Lone,
Rookville, Maryland 20852.

WW"J,,-TﬂvTY-mvm'wl'dn-WKV'WV-aa‘wl'

Dear Mr. Crook.

I look forward to participating in the site visit on
Hﬁah323. I have read the apolioation and am left with a
few questions whioh I would rather anticipate than come

-;-

.mvmmu

to the wasting unyroonrad.
Tho

.

qnostion

is raised

whether the

EEG

equipment

to

be utilized should be seen. I hsvo road-the activation
prooodnre carefully (page 2h) and find that the description
19 based on a visual analysis and does not reqnire any
computational equipment. An enquiry from your office
should be moan: "In what way in the oomputational equipmont

at the university of Maryland used to classify tho response?"
as I suspect, those are exploratory and are not applicable
It, the
proposed study. than a visit in unnecessary.
to
If indeed the mothoda are integral to tho classification

visit

should ho considered. (At the
minimum, it would be most helpful it Dr. Bunion can be
asked to have available samples of eaoh of the threo types

prooedure, than a

of classification of the ohloraloao procedure).

I recall a prior oyplioation of Dr. Mbnroe regarding
a similar study. Rio C.V. (page 10) indicate» there is no
other research aupport. If that prior application was not
fundnd, or has been terminated, no other action in nooenaary.
If that other application in active, than the relation
between this atuﬂy and that prior study should be described.

�Mt. Thomas Crook

December 22nd. 1972

~2—

Unless I hear otherwise, I plan to fly from mm».
to Baltimore on Allegheny 51:3, arriving in mtimore at
9.16 mm. on January 12th (I 1101‘ return rasemtion on the
5.16 pm. flight,-

AL

58h? .

could be changed to the

I

should time require

last flight.

AL 5&amp;6

at

look forward to meeting you.

Sincerely yours ,

Max

MF/id

no.

110

Dr. Donald P. Klein

Fink,

M.D.

it,

my

leave

8.1m p.131.)

�</text>
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                    <text>December 23, 1972

Roberts London, Esq.
515 Oxford Street
Westbury, New York 11590
Dear Roberta,

I have read the transcript of the heroin session with
interest, and wish to congratulate the primary editors, for sending
me such a clean transcript. I am especially grateful that you deleted
some of the 'off the record' remarks, and in that context some of
the discussion on page 25 seems audacious, and probably should be
deleted.
.

I have translated the 'qéﬂ' designations to English; and
have typed a few lines about the use of ﬁalline-- you may use these
as you wish.

I have added a few sentences to the last paragraph, noting
would
I
that
not hesitate to support a study of heroin, either
as a delivery system or as a pharmacologic study, in order to learn
more about its effects. That should be enough, but if there is
reason to give more support for a scientific study (say, through
Yale University) and not a political study (say, through a nonscientific and non—medical agency like Vera) I would be glad
to do so.
.

I have also added a reference to the article in your
earlier issue, referring to the narcotic antagonists, hoping that
such a refernece may be used in the text or as a footnote, to bring
your earlier report to the attention of the readers. After all,
a critic who is wholly negative contributes less than one who provides
a

better vision

and

for

My

and an

alternate road towards a solution.

best wishes for the continued success of your journal,

a happy and a prosperous 1973

!

Sincerely yours,
.

"Ir

luvs”.

m

‘
{we

.
Wv'w

gu:(

w

Il‘nﬂa'fm‘

Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>.W

.
.
.

v
..

m

h

.

December 26th, 1972

_

,‘..

wﬁ“~,._7m.,,.

Mr. Kenneth Bova,
,.‘..,,,,mv_wv,r~w

_.

Facilities Planning affine,
Administration h39,
SUHY,

Stony Brook.

Dear Mr. Bova,

behalf of tho Department of ?syeh1atry and my
associate: at International Aasceiaﬁion for Paychiatric
Research, I want ta thank.you for your excellent
recommandatinns, bath as to danish and as ta the contractor,
and for your guidance in renovating the EEG and aomyuter
facilities in the depurtmant at Surge I. I hava been through
renovations before, and can recall no previous cccaoion when
the planning and renovations went so smoothly and so well.
On

Plague aceeyt the enelosed
My

gift

on our

behalf.

vary best wishes for a successful 1973.
Sincerely yours,

Fink, M.D.
Professor of Psychiatry
max

MF/id
Enc.

�</text>
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                    <text>Decomber 26th.V1972

Jonathan Davidson. M.D..
Departnnnt of Payehiutry,
Behoal of Mediaine.
Uhivnrsity at North enrolinn,

mm]. mu,

1:.

ecu-onus 27515.

Boar Doctor Davidson,

I read your letter to Laneat,pablishad on Decembar
much interent. It 1. indnod true that attcntion
with
9th.
nhoulé b. p‘id to the cholinnraie npahanians or the
doprcaaion process. A: you knav. than. hav._boen ignpred
lnrxaly baatnae tbs anthoda fbr detorninntion warn
censiderod too poor and too «angle: to stimulate the

intcrcat at the young rososrohors.
I an taking the ltbarty of sending ycu a eoyy of
s thaorcticil esnuy that my gslo¢1cton tad I put together
more than a decadm ago, .t‘s tins when we vure intorontod
1n thn Ialutary struck: at RC? on daprtunlan.
Bineortly yuurl.

ﬂax Fink, M.D.
Professor of Pcyohintry

10/1.)
Eno.

�</text>
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                    <text>»
—

&lt;.«-¢",v-

am

.-'31=-V:-Arv:wr:rv&lt;V

Daeember 26th, 1972

v,“-

w-

4,_

v“.

779m

a-

INCH-m7?“

arr—r71

Mr. Robert

Darino,

Facilities Flanning Office,

Administration £36,
SUWY, atony Brook.

V'”

-

.vwowwzmw‘"

“y.-

,n
a»,

‘n':"‘b¢:4‘v&gt;q.ymu

a"

mm

Tau-Wa‘vpmmr(

pm

Mr.

Darino.

behalf of the Departmant of Psychiatry and my
associates az International Aaaoeiation for Psychiatric
Research, I want to thank yum for your Excellent
rocomnandationa, both as to design and as tn the contractor.
and for your guidance in renovating the EEG and comgutar
facilities in the department at Surge I. I have been through
renovatiana before, and can raeall no previcus occazion when
the planning and renovations want to smoothly and so wall.
On

Ploaaa accept the enclosed
My

gift

on our

bchalf.

very best wishes for a successful 1973,
Binearely yours,

Fink. M.D.
Professor of Psychiatry

Max

MF/iJ

Enc.

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                    <text>Docedbar 26th, 1972

Jonathan 0. Cole, M.D.,
Boston Statu Hoayital,
Boston, M333. 0212b.
Dear Jonathan,

yritz Ireyhana as editar of Comprehensive Psychiatry,
uhould be invitea to meetings at ceuncil of the APPA.
Unless thcre is some abjectiou, I believe he should be
inviteé t0 the next meeting. ﬁia present adareas 1!:
Fritz
2015

_

‘ID

Hy

A.
R

Frayhan, M.D.,

Btregt,

N.W.,

Washington. 9.0. 20009.

best regards.
ainaerely ycurs,

a...

.

MEX

p

MF/id

‘.‘.;7._,;.v..wﬂ.n_‘

—w;_

a?

7‘

=5,
.

11me

.

Fink.

”CD.

Prcfetsor of Psyuhiatry

"envy-x,

�</text>
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                    <text>.:-v.-

7‘;-

"-7"

1pm..“

war.»—

aFug-UV»

-

.
.,-.

,

t1‘&gt;&gt;vnr7'V1'l

w

9“,,

Deceﬂbar 25th, 1972

“a:

a
-_.

1-,W—«w.

Mt. Kevin Jones,

Facilities Planning Offica,
Administration h38,
6UNY,

Stony Brook.

Dear Hr. Jones,

behalf of the Dapartment of Psychiatry and my
associatas ax Internaticnal Assoeiation {Or Psychiatric
Research, I want to thank you for yQur excellent
recommandations. both as to aesign and as to the contractor,
and for your guidance in renovating the EEG and computer
facilities in the departmant at Surge I. I have been through
renovations before, and man recall no previous occasian when
the planning and renovations want 30 smoothly and so well.
On

.

w

-f$','_‘W.‘0\'—:‘r

Please accept the enclosed
My

gift

on our

behalf.

very best Vishnu for a successful 1973.

sincerely yours.

Fink, M.D.
Profeaaor of Psychiatry
Mix

MF/iJ

Enc.

�</text>
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                    <text>December 26th, 1972

Paul Kielholz, M. D.,
Psychiatric Clinic of the Univnrsity.
Basel, Switzerland.
Dear Paul,

I vary

much enjoyed

and your anthusinsm made
5 manordble one.
‘Aa wo

are

now

our discussions in sun Juan.
Swiss Chalet

the dinnar at tha

preparing a study

at acute

withdrawal

in cannabis. I read your comments to the WHO in 1971 and
in the 1970 issue of Dautacha Meﬁizinisehe Wbchanschrift
(95z'101s105). The paragraph on vithdruwnl (pg lab) is
must interesting.' Have you a more detailed aescription
of the behavior of the subjects during withérawal that
you may make available to me?
’

In chacking for tha 1972

WHO

repert, I find

it it

not yet available in
York. should there he data
or coamsnta from that meating that are relavnnt to our
interest, I vonld be neat grateful for your making these
uvaildble ta no.
Kew

My

best wishan for a

happy ana propperoun 1973.

Sincerely yours.

M33

Fink.

M.D.

9rofessor of Psychiatry

HF/iJ

&lt;

n.

t.

4941-,“

�</text>
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                    <text>A

.

Irww'h'

Dacanber 26th, 1972

wr.u7§"w

M?.'Gary Seidler, Editor,
Addiction Research Foundation of Ontario.
33

Rusaell Street,

Tbrento 179, Ontario.
Daar Kr.

ﬁeidler,

I have been receiving Ike Journal for the past few
at the ﬂaw York Madical

months at my pwevioua addrasu
0011333. I find year rayorts

of tn» arug scene excallant.

interesting

and the coverage

I wenld appreaiate continuation of the subscription

u
c-.

addressed to:

‘

Max

i
n

Fink,

M.D.

Dapartment of Psynhiatry,

p

fE

Health geisncan Center,
Stata University of ﬂew York at Stony Brook,

i‘

?

Stony Brook. 3.1. 11790.

Sincerely yours,

th

Fink, M.D.
Frofessor of Psychiatry
MF/iﬁ

�</text>
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                    <text>s,

December 27, 1972

Charles E. Wells, M.D.
Coordinator of Residency Training
Vanderbilt University
Department of Psychiatry

Nashiille, Tennessee

37232
LC

:

Fir.

HEX‘L‘TPOd

1:".

Zeidman

Dear Dr. Wells:

Early in hissehool career at New York iedical College, it.
Zeidman applied for summer work in this division. At that time we
were involved with the study of novel narcotic antagonists and he
carried out chemical assays and also interviewed patients. During
the subsequent years, he volunteered for a number of experiments as
a subject, in our assay of new psychotrOpic drugs.
In his relationships I have abways found him to be bright,
c00perative, enthusiastic, and dependable. He worked well with my
staff and with the patients. I believe he woulé make an industrious
and

enthusiastic trainee.

expressed an interest in psychopharmacoloyy and because
high Opinion of the program at your University, I was instrumental
in requesting—that he make—application for further study with you.

of

As

my

:3

:

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF:ig

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                    <text>X.
W:
v,

,

mel.

,(323‘
egg/wt».

1:."

‘
"yew

”1,,

new;

:A

A.

December 27, 1972

James a. JcPherson, A.D.
Chairman
Committee on Internships

Graduate School of Medicine

Mayo

Rochester, Minnesota 55901

"11'
M
galleries!

347:.-.

Easiest:

Dear Dr. ﬂcPherson:

Early in his school career at

new York

Iedical College. ﬁr.

Zeidman applied for summer Work in this division. At that time we
were involved with tne study of novel narcotic antagonists and he
carried out chemical assays and also interviewed patients. During
the subsequent years, he volunteered for a number of experiments as
a subject, in our assay of new psychotrOpic drugs.

In his relationships I have always found him to be bright,
cooperative, enthusiastic, and dependable. He worked well with my
staff and with the patients. I believe he would make an industrious
and

enthusiastic trainee.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Hing

�</text>
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              <elementText elementTextId="54273">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>December 29oh, 1972

Dr. Hugh E. Eueeey, M.D.
The Journal of the American Medioel
535 R. Deerborn.
Chicago,

Illinois

Association,

60610.

Dear Doctor Hueeey,

ere-pleased to enoloee a short report "Levomethedylz
Prolongea Duration of Oyioid Effects, Including Crone Tolerenoe
to Heroin, in Man" for your oonnidereiion for publication in
the Journal or the Amorioen Medical Aesocietion. With the
increasing use of methadone throughoui the notion, the incidence
of both overdose of methadone and illicit oiveraion have
increased the imoortenoe of the developoent of e long—noting
we

Opiate

substitute.

This study van undertaken at the request of the Veterans
Administration who, anticipating a more general study of
v:
.-

aw

on

an”;

rm.”

-:;

v

rt’mw'2~rxazmr‘;.:m'co.

‘

levomethadyl and methadone,

felt the

need for detailed

information regarding levomethedyl. Recently Jerfe and his
coworker: published their VII? of the aoetylmethedole (JAMA
222: h37. 1972). In this they cautioned that the more
general use of the aeotyinethndole would be fraught with some
risk. In our experience. their anticipated abuse of the
eoetylmethedole need not come ebout. end indeed~the substitution
of levomothedyl for methadone, it the patients are being
treaoed eoooraing to the latent governmental guidelines, should
decrease methadone spillage end opiate overdose deaths.
Thank you

for your consideration.
Sincerely yours.

Hex‘rink, M.D.
Professor of Psychiatry
MF/id
Eno.

�</text>
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                    <text>October 31, 1972

Demonic G. Iozxoni, H.D.
Endo Laboratorioo, Inc.
1000 Stcvart Avunua
Gordon City, ﬂow York 11530

Dear Dr.

onooni:

Ho how. been advised by the Roooarch Conaittoo of our
school to oobnit ovidonc. that on IND has been filed. and I have
taken tho liborty of sanding than n copy of your letter. In
addition, the Connittoo not. that the toxicology data be «ado
availablo to than. In chucking my 11138, I find that I do not
have this information and I would apprecioxo your sanding me o
summary of such other information that moy bu useful to out a ooorch Counittoo.

Many

thanks.
Sincoroly yours.
Fink. M.D.
Profoosor of Psychiatry

Max

Hfzig

�</text>
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                    <text>0 A 8 U
“~“-*’~~~.«"
H E

M

R

D

M

October 31. 1972

hrs.

T0:

J.

in

Fmdun,

11‘.

Jon“. 3.

Lavina, R.

Mulch,

Volawkn, A. Zak: and Fran "c1801; and Sonna Durbin.

Dr. Max ?1nk

FRGM:

There

A.

will he a sitting of the ntndy tuna. for narcotic uddiction
offtcc on Hiddnlday, November 8 at 10 a.a.

Dr. Frondnan's

”nu—“m“...1.

Frost-no reports on ongoing studias.

2.

EN-1639

3.

Enroin study (relationships with Dt. Incurrini and Dr. Mule).

6.

Nan

luvontthldyl protocul.

�</text>
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                    <text>November

2,

1972

Elmer A. Gardner, K. .

Birector

Department of ﬁenlth, Education,

and welfare
Public Health Servico
Food and Drug Administration
Rookvillo, Maryland 20852
Door A1:

Encloaed is a preliminary report of our atudios of high
dose oyclazocine. This report summarizes the data as of
September 14, 1972.

to

24

Sines than,

.3. daily.

we

have incroaaed dosages

in three patients

We wish to award our protocol to indicnco that we will
increase daily doomgos to 33 mg. and assess rho tolerance to this
deco, coo tho duration of antagonism to 25 mg. horoin at 48, 72,
96, and 120 hours.

Sooniok.

The work

continues undo: the direct supervision of Richard
Sincoroly yours,
Pink, Hobo
Professor of Psychiatry

1‘18!

£3213

inc.
cc:

9.. Ran-nick

A.

I.

Prooooan

�</text>
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                    <text>Bovember 3, 1972

Editor

JANA

Chicago,

Illinois

Dear Dr. Hussey,

I have taken the liberty of writing a formal letter to
the JOurnaZ in reply to the cautions raised by Jaffe and his coworkers last week.
issue of further study of long acting methadols is
for while neither methadone nor the methadols provide
a realistic solution to opiate dependence, the methadols may reduce
the amount of illicit opiates freely available in the community,
The

an important one,

thereby reducing the hazards of death and increasing spread of
opiate use.
rm.-

,,

.

'Jmlwivi’lm'vnmww

rJ:

Mum

crew's

I believe the Journal should provide editorial leadership
to the profession. To the knowledgeable reader, the cautions expressed
by Jaffe at 31. suggest that the leaders in Washington will slow down
the development of these compounds, using the need for more extensive
aniial and human studies before more extensive trials can be undertaken
as a legitamate and se1f~reassuring rationalization, Indeed, that is
the reason why the authors selected the unusual step of including
a section of opinion in their report, labelled Every Silver Lining is
Attached to a Cloud.
the ultimate solutions for opiate dependence

W'mﬂmwp‘u

-‘

:9
V‘T‘H‘.“

"."

.'n

illicit

do

not

lie

in methadone nor in the scetylmethadols; but for the immediate future,
the hazards of methadone must be weighed not against some ideal but

against the realities of these long acting methadols. In our hands,
the methadols seem sufficiently safe and sufficiently important as
a replacement for methadone that every effort should be made to encourage

this development.
Your

editorial review is solicited.

W‘s-wr‘mqvxw'w‘v

Sincerely yOurs,
51'“sz

vmgw

.~v«rrrw~1v;,

"-“

A"

mm”

‘4""17

wwwq

Max

Fink, M.D.

Profesor of Psychiatry

�</text>
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                    <text>June 16, 1972

Mr. Robert Cuddihy
Drug Information Bulletin

Sandoz Pharmaceuticals
Hanover, ﬁew Jersey 07936

Dear Mr. Cuddihy:

Enclosed are two copies of the report “Quantitative EEG
CNS Bioavailability of Psychoactive Drugs“, which
was presented to the BIA in May, and which is submitted for your
as a Measure of

consideration for the

Drug

Information Bulletin.

Sincerely yours,
Max

Fink, H.D.

Professor of Psychiatry

MF:ig
Enc.

�</text>
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                    <text>m» 'w‘I—m‘n—I'm'w ~m-u~,hn~rw-m—.

wan-Imm-

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lovubcr 3rd .

1972

Hr. Robert Gummy.

Drug Information

Sandor

Bulletin,

Manuals.
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I report "Winth”mad.
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I

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Sincerely yours .

ﬂax

rink,

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M?! 13

m-

�</text>
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                    <text>lovuibcr 3rd. 1973

w. z.

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unborn , Pu. 190’“).
Dear Hr. Hicgnnnn.

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mavo1d its satt1ns

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Sinaercly yours.

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                    <text>Revumbor

3rd. 1972

ur. Charles Cannavu,
6 Oxfbrd Place.
Mnﬂuapqua. 3.x. 11758.
'

Dear Hr. Cannava,
Thank you wary maeh for your invita$1on to participate
1: your lecttre program. Aﬁ tha present ﬁlms I an
frequently asked to talk shout a number of nubaeats,

inalnding narcetie ;ntngonista tad opiate dapandance,
thcarion of ECT. and quantitqtivo EEG and paychopharmacology.

I graduatea

Rev Yerk University College or Mbdicine in
und was Director at Research in Killnide Hospital.
1952~623 Director of the “lunauri Institutc cf Psychiatry
(8%. Louis) 1962~66; and Director at the Division or
Bialogieal Psychiaﬁry, new York Radical College, 1966~72.
At prssont I am Profeaaar of Psynhiatry at tho State
university of Rev York at Stony Brook.

lghs.

Thank yuu

for your invitnﬁion.
Sinceraly yours,

Fink. N‘Dm
Profeasor of Psychiatry
MF/id

�</text>
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                    <text>Hovubor 3rd, 1972

Prof.

331°.

3.

march,

train Uninnitit Berlin.
Payehiatriooho and Rummage» mum:
1000
Berlin 19.

und

Poliklinik.

Huslhnunlllea 36.

W.

E

_

,

.

Gamay.

Dounacter'nnanki,
The proper

vzmzwg

-

a

antics.

fur the that: reports

than: you

u. follow:
Fink. m. sac Clnltificjtton or Pnyehoaetive
(Impound: in ma: Rum: and Theory of Behavioral
Associations. Psycvhophmmaology - A Ravi-v of

rcquutcd

$674987, can.
Ema, J. Cole, J.
Wu,
Levine and LR. mtmbcm, v.3. Govt. Printing
D.

Office. wuhimon, 13.0..

‘r‘-1',VWR?"‘\;&lt;VWDM‘:§!‘ﬁer'w'5'?,:241er'"11

PP. ”97’507’ 19690

ﬂak. M. and 11:11. '1’. m an! Hum Psychophu'ucalosy IV: Clinical Antideprumtn.
Ibid. , 671482. 1969.

.Ww‘J'zﬁv—mw

mm. It. and

of the
lam-Wiener
19690
MMiOt. W4, 1231'”.

.

11:11. T.

I look forum to toting

it is M11011“.

W

I.

can of thituport

but "suds.
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when

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                    <text>lovodbor 3rd. 1972

Dr. Edward Eunin.

Director,

,

Divinion or Payohintrio Trtinins and Education.
at. Vincent's Hospital :nd Hodiool Canoe: of H. Y.,
lhh whit 12th Etta-t.

new

York..l.r. 10011.

Door Doctor Bunin.

I would be pleased to portioipote in one of your
departnonﬁnl conforonooo. I would nascent either
rhbrunry lot or 8%h. 1973.V During my last visit. I
tglkod thou; narcotic Inttgouinto. and if you would
like u followup on than. us toll :- lovonothodyl, I
V111 be also to present the rectum data in u talk
entitled "Roeont rosooroh 1n opiotc.cdd1et1ou”.
Altornnttvcly, I on now involved in unannristnc
dot. tron 3 recent contoronoo on clootrooonvuluive thorapy
god it might be astral to prosont the theorion cod
neurophysiology of HOT 1n n tolk entitled ”Boas clues
to tho avsoory or BUT”.

I

hnvo

recently coooptod an appointment ut the

Btoto Univcruity of

b.

moaned

st

new York

(516) hamzhlw.

It

Stony Brook, nod

I can

Binoorcly yourl.

ﬂax

rink.

M.D.

Proton-or of Psychiotry
Hf/id

�</text>
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                    <text>ﬂovaabor 6 , 1972

Door 31:3:
Mr. Barry Sullivan 13
now compound.

participating in a study of the CH8
It would he holpful if he could complete
the proton: study by caning to the lab on friday, Runabout 17 1: 12:30 pm.
We would approcltta your cooperation in this regard.

effocts of a

Yours

truly ,

Fink,
Professor
XIX

1‘43?

:13

34.3.
of. Psychiatry

�</text>
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                    <text>November 6, 1972

Contracting Officer, NIMH
5600 Fishers Lane
Rockville, Maryland 20852
Dear

Sir:
We

have seen an informal notice
1 pharmacology

bids for the study of pgase

antagonists, Notice
We

SS-NDA—73—S.

would appreciate a copy of

have been interested in the

clinical

that

NIMH

trials of

is requesting

novel narcotic

this Notice. For

some

years

pharmacology of narcotic
antagonists, and believe that some of the methods we have developed
using EEG quantification may be applicable.

we

Thank you.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>Rovember 8, 1972

Dr. Gordon

Jueter

ReurOpeychiatric Evaluation Unit
Yale~ﬁew Keven Hospital

inertial

New

Unit - 10 Heat
Haven. Connecticut 06504

Dear Dr.

Jester:

the request of
experiences with him.
At

Mr. Joseph

Reylor,

VG

are

amusing

our

volunteered for e series of experiments in which subjects
receive, at weekly intervele, single orel dose: of psychoactive druge.
The dosages are selected as "threshold" ~ the minimum
necessary to
He

elicit behavioral or

verbal behavior.

EEG,

physiOIOgic

heart rate,

effects.

The

and mental

recording includes

status. Volunteers are

males, over 21 years of age, with e history of drug use (usually cannebis and hellucinogens).
goal of the study ie to define the
correletione of psychoactive drugs.
The

Mr. Baylor

have n normal EEG.
dicated no symptoee
He

EEG

and beheviorel

volunteered on April 12. 1971 end wee found to
A screening interview we: unremarkable; he
inor treatment suggestive of mental illness.

bed an adaptation experiment in which he received e plecebo.

On April 22, May 6. May 13, end May 20. 1971 he received
four coepounde; dieeepee 10 mg., placebo end two new beneodieeepenes
related to diexepem. During each session, ﬁnd in the poet eeseion
period ee reported the next day, be exhibited the usual symptoms of
mild sedation. From the self reports, it was not possible to separate
active drugs from placebo, although the EEG recordings were distinguishable.

�Dr. Gordon

Jueter

Hovember 8. 1972

efter the last session, he called to say
reported thet he had been involved in an
accident a day after the third EEG aaaaion. and insisted on knowing
the nature of the drug given. The cane information described before
the experiment was described again, and he was told that the sessions
included placebo. A physician we: not available the day he visited,
and he was asked to return the next day; but he did not.
Sir

he did not

weaka (7/9/71)

feel well.

He

On July 31. 1972 (after one year) he came spontaneously to
the study unit and was seen by a physician, who noted that Mr. Raylor
complained of headaches, intolerance of heat. feeling dazed, meleiSe
and trouble with concentration. Also he reported "electrical static
sounds from inside my head". The physician found him anxious, eoee~
what diahevelled. and perueveriug about the question of drug: causing

his symptona.
Be

inaiated again on knowing more about the drugs given him,
told about the general nature of the compounds, their

and again he was

sedative qualities, egg.

he did not seem

to accept this reassurance.

The new compounds used in the study were given to 23 subjects,
without untoward affect, and have since been identified an diaaepee-like.
undergoing clinical trials as oedetiva—anxiolytica.

I trust these data are useful.
Sincerely yours.
Fink, 3.9.
Praia-cor of Paychiatry

Mex

MF:ig

�</text>
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                    <text>October 31, 1972
Mr.

Earl Ubell

CBS~ TV

New

York City

Dear

Earl,

For many nights I have enthusiastically watched your new series,
Nutrition to Z; and just as avidly, switched to Frank Field for the
weather. Sometimes, I missed one of you
A

Now, I can look forward to seeing both of you on NBC-~ that
the Times announcement of your promotion to News
understand
I
is, if
NBC.
Director at
Congratulations ! I am sure that if yourbring to

this

new job

NBC-TV news

the perspectives and thoroughness you brought to
will soon head the Nielsen ratings.

My

CBS-TV,

best regards.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>navcubcr Sﬁh. 1972
Vinnonﬁ Dela. M.D.,

'

Rockefeller Univursity.
Ibrk Astana ‘nd 66th 8%..
York

Next.

City, NJ.

has: Vince,

.

Enclosod 13~n more ruaont summary or our uxporieneos
with luvnmnthaﬂy1.. Wt tr: ingrained that.uhnu1d
levonothndyl prove to be an affective in'mothndono. its
acnura1_uso any roduco thn availability or illicit
Inthndono.v In thin View, '0 1r. probdbly more opttnistle
thgn Jutte and hip co~vorkcrs,.who rcatntly reported

their experiences with nathadyl acetate in
‘
'

As you any

that, I as moving

stat. Univerltty of new
try ta cutdblinh

n

York

tro‘tpant

my

J.A.M.A.

lsborutorics to the

at stony Brook,
3nd study

nnd

will

unit gt Ebrthport.

'_ Btneoroly yaurs.

‘

nr/id
Inc.

Fink. M.D.
Professor of Psychiatry

Mun

�</text>
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                    <text>lbvuibnr 81h.11972

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                    <text>‘2.»

d

Louis

Gottschalk,

A.

November

9,

1972

M.D.

Professor and Chairman
University of California

Orange County Medical Center
101 South Manchester Avenue
Orange, California 92668

Dear Lou:

Enclosed are copies of the
proposal for an examination of the

RPR
EEG

and a more detailed study
and blood levels of butaper-

azine. The study did not get off the ground, principally because
the investigator suddenly left the V.A., and I have not replaced him.
Recently I wrote a summary of some of our EEG studies from
the point of View of bio~availability, and enclose a copy.

The subject of blood and brain levels for drugs in intriguing.
One would anticipate good correlations, but for many drugs, a blood~
brain barrier seems to operate, or, the CNS effects seem to exhibit

step functions, as with lithium and cycloserine.

I hope that you will find some way to measure the
as carefully and as reliably as the blood measures!
Good

luck, and

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF:ig
Enc.

Bioavailability
Cycloserine

RPRrButaperazine

EEG

changes

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                    <text>Navomber
1!.

Gilbert

10th. 1972

McMahon, 14.13.,

Protesuor of Medicine,
Tulane University School of Mbdicine,
1h30 Tulnnc Ave.,
New Orleans, La. 70112.
Dear Doctor Moﬂhhon.

'I look forward to participating in the session
I meat change in title to -

on March 2km.

D

on.

"Use of the EEG in the identification
and classifiettion of new ysychoactive

agents.”

I would appreciate Mina lined as Ms: Fink, Md). ,
Professor of Psyehiatry, Health Sciences Center. State
University of New York. sway- Brook, 3.1’. 11790.

mil either to the

Yen can stand my
my 13.0. box

address or to
11022.

-

Box

I look toward to using

Etony Brook

’269, Great Heck, 3.x.

you

in

Maren.

Sincerely yours.

Ma: Fink. 14.1).

Professor of Psychiatry
WI 13

�</text>
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                    <text>‘5»;

ubvuubor 10th. 1972

a. Paternal. PM)”
new
Chief, Center for Btud1on of lureatic
Int1anal Institutn at Mtntai nunlth.
5600

and Drug Abuse,

richnrl Lane.

RattV1lle, lhrylnnd 20852.
Dear 36b,

£ur1nc the f1rnt three months of thc extended eontrunt
nau~h2~70~98. Study of aannnh1a “nor: in Greece. we hnvo

couplettd the tollaving port1ons of the progrin

Chron1a hnnh1lh 38!?! wire naked to thuntcer 1b: ftro
1.33103- ut‘vuekly intervnls. to snake hash1sh, unrijnnnn.
THC 1nmrbgntted pitcebo. and pltoebo.
Hashiuh was in two
dons, 3 an m. 2 m (equiv-.1.» to mo .3 and 159 mg
TKG~A*9). Hir1juan¢ rt: 3 an oqn1vulont to 75 as THCnAuQ.
228~A~9 Vll inprisnntod 160 as in tho plnoobot All cigtrottos
ware of 35 gm total vu1ght tan flllnr was tob‘aac, unproxinntely
k gm and tan renaindar l.I.M.H. placebo. During the first
turn. south: 12 nubaactu tangletod five sessions cash} (wt
have n1nce aunt add1t1ontl sapplica sad 8 more nubgoetn are
in procai- dur1ng Octobar and lovuuber).
Tbs EEG roeordn at tho fia't 12 aubjcata were pent to
us in nidoayytqdber 3nd their tnulytis has! been templetcd.
sine..thn study 1: onso1ag. thay are sending-u. the EEG

tapes as thcy aauplatl than. Vb anticipate the stutistieal
anulyiia should be done 1n December.
roport cauparins the saciul tad
haah1nh “law: u1th the first
group of control. « a cunnnry of which #31 sent in August ~
28 additional control: wort nurvoyud during thy summer. A
prol1n1nary annuity of that nut; 10 «nclosed, no presented
by Dr. Stcfunit and h1s eo~v¢rk¢ru to the 6.131.? uynpos1un
on ennnabit, held in Caponhsgen 1n mideugust.
relieving the

sun—try

nadictl ehnructor1st1cs at tha

Uh hnwu

had only can aer1oun

difficulty vhich vs: brought

attontian during thi past tow vuekt. Our protacol
roqu1r¢n us to bring tubaocts into tho hospitnl and have
than ntop Innk1nc 1n nrdsr to study ths withdrawal phnnaunnu.
Br. Stefania writes thst ha 13 f1ndins 1t difficult to motivate
to

IV

�Robert

ureter-en,

PM).

«2-

November

10th. 1912

the nan, and that thq funds allocated for doing so are
1n:deqnuto. Be doubts that any subgcct will rangin in the
hnlpital far that thcy untiaipate to ‘n extraordinnry
anxiatyaprovoting situ:tion for lean thnn 1,200 draehnns
($h0) P‘r day. ‘I an rovinvin¢.th13 prablan tad vill
approach Hr. Grndvell and youraolf within the next few
vodka with 3 specific auggaation;
Our present plgns are to provide t dctuiled analypil
the
bahuvioral, EEG. pnyuhological and othur physiological
at
mascara: in in: neat: pxpcrinantu or 20 subjects for our
quarterly raport dun on or nbout Jcnnnry 15th.
.

Siﬁcerdly fours.

Ml: Fink, M.D.

Iliad
Enc.

�</text>
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                    <text>November 10, 1972
Leo G. Abood, Ph.D.

University of Rocyhster
Rochester, New York 14627
Dear Leo,

In a recent discussion of the role of cholinergic agents
a report written by you in 1961 was brought to my attention:
Distribution of Piperidine in the Brain and its Possible Significance
in Behavior, NATURE 191: 201-202, 1961.
on

the

CNS,

Have you done any subsequent work

particularly in other spetiee

as to where I

may

Many

?

If so, I

find the reports.

thanks, and

my

with piperidine,

would appreciate some

direction

best wishes.
Sincerely yours,
:2

Max

4

f

1/

Fink, M.D.

Professor of Psychiatry

�</text>
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                    <text>lawlibor lhth.‘l972
Br. aﬁorga cotstnn.
nodiatl nupurtnnnt,

arookhnvun Rattanal Lnboratary,

Associutnd'vntvcrstttou. Inc.,
Upton. 5.1., 3.1. 11973.
Dun: Doctor
bunk

Catlill,

1 vary mach enjoynd an: dineusnion lgnt tank. I want
und sought my comet on tho atructurc at

ta ly.t11¢a

untieholinorsic drucu. ‘Aa thtt tin. I VI: inmrcoaod that
tun roots touted to be present tar halluainasonte activity
(detertbod below). In lacking ovur thou. ants: tod¢y, I
bolicvo aunt oougouads with oﬁhar structuring 11.6 thaw
untieholinorsic nativity :nd thut that. natty nrc incanplato.
1 us analuulnc non. of the raprintt an new sad my
exparianaa‘vith snticholintrsies in: your intbrnntion.

Should you with a pnrﬁioipnnﬁ tram this dapartncnt
at tbs nit: visit on Daccibor 20th. Dr. 10119: but no
dbaoatioa. ’I would b0 gl‘d to puttiaipctc. 1: this in at
noun hnlp to yea. but would 111! tho opportunity to road
tbs intbrnntlon vhiah yen hart tdhnittnd prior to thnt date.

atnccrtxy yuﬁrs.

m ’1“, “‘13.

Protonuer of Plyahintry

Milt:
Stet

�</text>
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                    <text>Howrah-Gr

Dr. T.

1972

Itil,

Missouri.

Institute of Psychiatry.

5M0 Arsenal

8%...

lath.

street,

Louis. Human-1 63139.

Dear
._

m.
much-ad

&lt;1-

I

copy

a:

aw

“evading lettu-

Mmtm Jam for mas-ﬂair: 1n tho-.10.3.9..
Plans write a letter of Minimum.
while you were many, I worked hard for you,
Waited nu- aontrdmma to your back. I also
had Boranatain’s aontributien. I do not envy yamwlth may of his
rasponubinty, Mme I
.

and

um
W
u; mums.

now-mu. I think 111: new» are excellent. and
paup- you ahead publish tha report an 1:.

I emf. your

$911:

M

was uneventful;

81mg"); your: ,

ﬁnk. Mm.
Prateucr of Psychiatry
Max

tum/1.1

Bum

�</text>
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              <elementText elementTextId="54042">
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  <item itemId="5403" public="1" featured="0">
    <fileContainer>
      <file fileId="5924">
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                    <text>Huvenber

Janathnn

lhth,

1972

Cole, M.D.,
Cha1runn. Credential: Gounittoﬁ,
A.

A.C.H.P. 3'
Boston Btntg 80391111,

Boston,

mu.

02121:.

I

D91: Jonathan.

I take great pleasure in ooaondtng the nan1nation or

JoVHn Simeon, M.D

1111 v111 pond you

currieulum vitae.

I have

fur unuburahip in the 1.6. H.P. Turun
a letter at nan1nntton and tn updutod

known Dr. Einaon

tine:

1955. vhﬁn

b. Joined

1h. Missouri Institute of Psyeh1atry. “hen I moved to
Run York he Joined me there, 1nd I have been acquainted
with h1m and his wbrk thcae noven years.

1: a wall tra1nod phyiieiun. method1aal and
careful in his work, v1th an tutoreat in clinical paycho~
pharmacology. Bo carried out systematic studies 1n
Ba

Hiasouri and

ﬂew York, and

I found

h1a work exemplary

At one point 1n h1s cutout he beans: internatcd 1n
tho upoo1:1 prcblann of :dolunaunco and chtldren, tad
.duvvlcpad a study pragrua 1n.tha effects of pgychanct1vo
drug. 1n than. populnt1ons. no beo¢ne enthusisstic about

this effart.
‘

For_a variety 5! pornonul reasons, ho,returned to
uinee entiblishad a study unit at tho

8%. Lou1s and has

ulnsouri In1titnto of Payeh1atry. He knows the literttur.
wall 1nd I b.1107. his. and V111 aontinua, to eontr1butc1
te- clinictl payuhcphsrnaualoay

I rononnsnd h1- nnuborthip to the A.C.N.P.
ha will contr1bnte to the wasting.
'

nu

I boliova

Btuccroly yours,

that

nr/aa

rm.

um.

Prorhsnor of Plyahiutry

�</text>
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                    <text>mmnmwxmw

A

November

1hth. 1972

Allen Rankin. Ph.D.,
Beeenreh Psychologist,

Peyehapherneeology Research Branch,
National Inetitute of Mental Health,
Sksh ﬂinconein £70.,
Chevy Chase. Maryland 20203.

Deer Allen,‘

I can underetend ﬁne relucteuee or the eaumittee to
increase the costs of the project. In our review, we vere
impressed that the daze an the etfeets of hypeﬁberic oxygen

lent themselves to a more rigoreue measure by using
phyeiologieel indieee.

Perheyl, if the first study show! eons cheese: which
are of clinieel merit an a result of the procedure, then
perhaps the more deteiled studies would be warranted.
my

best regards,

”Whi-

mmmm‘vv

i

sincerexy yours.

1“!

Flu.

Mad).

Professor of Psychiatry

MF/iJ

�</text>
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                    <text>mmww

,

(’1'

nova-ﬁber 113th, 1972

Wt,

Janus” L. shun-mi. «In. 11.0.,
Human
mints-mum Hawk-1
n...

hum
momma.

I.

,

‘

-.

11768.

30: 632/151

M 13661»: show,
to “tend thc aunt-ch
I up» thatonI will be mm.
Contact
20th,, :1 I V111 be on s tits
acting

low

V1.“ in Detroit that dam

.

smartly
2

in:

your: .

nu.

I’M).

Profane:- of
.

mm

thtutry

�</text>
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                    <text>lovcnbgr 15th, 1972

Riahtar,
Dirnctor, Departnmnt at Henralosy.
Callas. of Phyuieiuni &amp; Surgeons of Columbia
University Enrlan Bhuyitnl cantor.
136th St. and haunt Ar...
Dr. Ralph

W.

new York.

3.!.

1003?.

Dear Ralph.

i

Enclosed is coyy of ear nannunript ”narcotic
Antaganiat-Thnrapy of Opiuto Dcpcndtnee" for the volume,

Truatuant. I took the liborty of inviting my
converter. Dr. Richsrd Renniak. vho hgs done meat of
the attinitivc work an eyelguocino, to writ: thin paper
with an.
Modern

I hope that it tact. your needs. I look forward
to ucuins I copy of the voluna‘
'

NV

hast realrdu.
Binncraly yearn.

mu. m.
m
Profs-car at Psyuhiutrr
ur/xa

m.

�</text>
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                    <text>iéovembor 15 , 19 72

Elmer A. Gardner,

24.1).

Director
Division of Europharnacologlcnl
mug Products
103-435, ED 125
Food and Drug Administrotion

5600 Fiahorl Lone
Rockvillo, Maryland 20852
Dear Dr. Gardnor;

Robert Lavina.

31.3).

will represent the

Lieu

York ﬁedical

College .. Ehtropolitan Hospital Drug Abuse Study Programs at the
FDA sessions on methadone on. December 4, 5 in wow York City.

Please address further oomunlcationo to him at: Department
of Psychiatry, New York Medical College. 5 East 102 Street. biew York.

Row

York 10029.

Sincerely yours .
ﬂax Fink. 3-D.

Professor of Psychiatry

£4ng
cc:

A.
R.

a.

Freedman, 24.1).

Levine.

£4.33.

�</text>
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                    <text>Q

ﬂavonbor 15. 1972

Samuel. c. Kain, em).
Coordinator, VA—SAODAP
Steering Connittoc
Veterans Adniuiatrution
Bepartmont of ﬁndicios Ind Surgery

Hashington, 9.0.

ZQéZO

Dear Sam:
The preposal for a cooperative study evaluating the usa of
narcotic antagonists in withdrawal of addicts from nothadona maintenance is interesting. I have a tow questiona which may olucidatc

the proposal.

1. The record does not indicate the basic for the choice
of domepin as an antidepressant, rather than imipracinc.
2.

Why

are sufficient?

elect s

21 day

induction to cyclasocino

whoa 4 days

3. Why scloct 6 mg/day no the done of cyclazocino, if antidepressant activity is to be tested, whom the antidepressant activity
of cyclazocino has baen demonstrated at 1 1/2 to 2 1/2 mg/day in
dopressiv: patienta? Or, is part of the tout a comparison of nor—
cotic antagonist activity of cyclarocino with doxopin‘s antianxiety

activity?

Jeff: and Sonny (pages 3~A) suggests they
and phanothicxines in small doses,
antidopressanto
tricyclic
useful. By what criteria? The can: quostioua are raised for the
data of Kline and Pfizer (page 5).
found

A.

Raferoncs to

5. 1a a ton sock withdrawal from mothadona fcoaiblo? Would
such a slow withdrawal allow a high rate of racidivism? Perhaps, a
more rapid detoxification, at 5 og/day for 10~20 days would be foa-

.ibha

�J”

-\-‘:‘
,

Hovombor 16. 1972

Sonuol C. Kola, M.D.

Barman

6.

For adverse

rotations, the protocol auggasto roaching
is unoful only during busi-

or myself.
I ouggoot 516-‘i4-2413 or

noos hours:

The Stony Brook phone

516-466-5444 evenings and vookondo.
Hy

2&amp;6?

during businooo; and

boot Vishnu.

Sincoroly yours,
ﬂax Fink, H.D.

Professor of Poychiatry

ﬁing

�</text>
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                  <elementText elementTextId="103693">
                    <text>November 17, 1972

Dr. Watson Reid
SAODAP

The White House

Washington, D.C.
Dear Dr. Reid:
Your

letter regarding the

V.A.

collaborative study of lava2 was sent to me for

methadyl addressed to Dr. Zaks on November

reply.

have sent a copy of our latest report on levomethadyl,
”Levomethadyl: Prolonged Duration of Opioid Effects, Including
Cross Tolerance to Heroin, in Man”, to Dr. Gardner.
We

have also sent Dr. Gardner an amendment to our IND 6590
to extend our studies of levomethadyl. We trust that we
will have the enthusiastic encouragement of SAODAP in this study
We

and 6825

as well.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming
Enc.

cc:

Levomethadyl, 9/26/72

A. Zaks

�</text>
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                    <text>November 17, 1972

Dr. Elmer Gardner
Bureau of Drugs

Office of Scientific Eveluetion
Food and Drug Administration
5600 Fishers Lone
Rockville, Maryland 20852
Deer Dr. Gardner:
Enclosed

end IND 6825

is

an amendment

for nethedone.

to our

IND

6590

for levonethedyl

At the request of Dr. Reid of SAODAP, we ere enclooing a

copy of the latest report of our studies of levonethedyl, which
be useful as date of phelezl studies in men.

to

We

are submitting the usual request form: (BHDD) for material
will underteke the study about January 1, 1973.

NINE, and

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Hex

33:13
ﬁne.

may

Protocol 11/9/72

Letter

Dr. H. Reid

Report, Levonethedyl, 9/26/72

�</text>
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                    <text>November ‘17, 1972

Hr.

G.

Boyer

Division ﬂarcotic
.

mm:

&amp;

Brag Abuaa

500 Fishers Lane
Rockvillo, Haryllnd 20852

Door Mr. Boyor:

Enclosod is a formal BN9!) order mounting.
mthadyl for the continuation of our studica under

750 mg.

IND

levo-

6590 and 6825.

are also meiosing a copy of the protocol submitted as
sundown to our 181). The amount requested will permit the study
of 50 patients in a more definitive evaluation of levomthodyl and
We

an

methadone.
Wu

anticipate beginning this study about January
Sincerely yours ,
Max

Fink,

31.33.

Professor of Psychiatry

MI?

:13

ﬁne.

cc:

H. F. Dummy, 14.2).

_:_.

1.

�</text>
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                    <text>November 18, 1972

Division of Research Grants

NIH

Bethesda, Maryland

20014

Gentlemen:
We

would appreciate receiving 3 copies of the NIH

”Grants for Research Projects: Policy Statement", DHEW publication
(NIH) 72—8, dated July 1, 1972, for distribution to the principal
investigators in our programs.
Thank you.

Sincerely yours,
Fink
Executive Director

Max

%

E

mf/

�</text>
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              <elementText elementTextId="53942">
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                  <elementText elementTextId="103690">
                    <text>Noveiber Elat, 1972
V. Russell TAylor.

D1roctor,

n.9,

01131¢A1 PhArnacology ~

Toxicology Center,

PhilAAAlph1A GenorAl Eonp1tAl,
3hth 3%. And G1vtc Center Blvd..PhilAAAlphiA, PA. 19103.
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(nArcotic substitu$1on Thsrapy)" v1th much
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rink: vh1ch society 1A willingly taking, to the Aztont1on or
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obaeat1onl to hcro1n AA11vAry, And for tn: tins bctng thi-

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know more should be AonA.

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CongrAtulAtianA on

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’

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Fink. MODE
Professor of Psychiatry
M7113

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                    <text>”WW.

w.

.v “‘3‘“

nvw-‘w~,w.w a."

m.—

ruwl-y-

trm‘ rvtlmv .

-..w

Bovuibor 213$, 1972
Eugene M. Laska, Ph.D,'.
Research Centcr,
Boekland State Koayital,
Ortngdburg, 3.1. 10962.
Dear Gene,

I hava been published in

German, Csech, and Turkish

—'

but the Rutaian was a first. 12in pletsod, and cansratnluto
you'on the industry which fblterod this necompliahnsnt.
.

My

congrutnlgtiom

,_

m but roman;

Sincgrely yours,

?1nk,
Professor
Mn:

NF/id

M.D.

at Puyuhiatry
.

W::EFF—R‘-w_—x~mv-ﬂ .7“

�</text>
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                    <text>Bovuubor 213%. 1972
scymnur

Ehrenpreil. Ph.D..

Ch1o: of Pharmacology,
New York State Research Inat1tuto
'tor Heurochcniutry and Drug Addtat1on.

Hird’a Island.

H.Y. 10035.

Boar Boynnur.

I would ho glotaca to eontribu$o g «barter on tho
clinical «valuation of narcotic antagon1sts, including the

use of heroin cha1lensen. pup111osraphy, rosp1ramstry,
tad EEG; sad the special applieatlons of rapid detoxificat1on
with nuloxone, in an urticla titled ”Evaluation of Enrcotic
Antasdn1hh 1n nun".

Hovevor. I bel1cvn

I

abould know the

f1nancinl considerations fbr the partie1pants before
caln1tt1ns the tin: to th1n 1ntercst1ng nttort. I vou1d
connidcr $20~30 t nannncript page or 8h0~60 I printed page
(canlud1ns references)

ta uverago.

81ncqrely yours,

rm. 1M).
m
Proteusor or Paychittry
u!/13

�</text>
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                    <text>m,

,

_

u . «aw—ﬁww‘TKJ‘mxerVIU-t

novunber 213$, 1972
Craig Harrell, H;D.,

Bunion Pharmaceuticals.

Hunav'r,

New

Jersey.

Dnnr Craig‘

I ﬁt: in thc dontul choir of

tall

my

dour. long

tin. friend.

Loo Zaah, vhnn he began to
as of his usuoetntion and
var: with you. He no captured my att-ntion that his burrowing
in my unuth became painlean. You are fortungte in having such

a soyhiutieuted nnd

critical scientist assist

you.

All wt: V‘ll until ha sngganted there may bc Ions
airman-ace in our reluttonahip. I was surprised, tsauning the
luck at contact van related to the lack of prdbluns tannible
to I: novul teahniqucu. rather than any person31 differenccn.
I natured him. that I gm unsunro of guy dissonanec.

I trait all 1: wall in Ennovnr. since #0 last ant. I hsvo
laborutory to tho paaturcl of eastern Long Isltnd, to
tho ncv nedtctl school gt the Btgtu University of How York tt
Stony Brook. Gong visit when sort you are truvellins «:08.

moved my

Sineeroly yaurs.

Hi: link,

M.D.

‘

Prcf¢saor of Psychintry

Milia
cc. Dr. Leo

mu

-...,.- :. ar' .'v«~-.rr--rw-~v-w~

�</text>
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                <text>1972 </text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>ﬂovonbor 22, 1972

Alan Ramsey, M.D.
Modicnl Consultant

National Inititute of Mental Health
5600 Fishers Lena
Rockville, Haryland 20852
Boar Dr. Ramsey:
Undnr the torn: of contract
studies are in progress.

88M

42-72—207, the following
_

(l) ﬂelogeridgl. Twonty~four opiate dependent non have
been withdrawn from heroin using decreasing doses of methadone and
placed on either halopcridol 10 mg or placebo. Both groups have
been given 4 mg of benzotropine with each dose of active drug or
placebo. he methods of evaluation set forth in the contract are
being uncd. The remaining subjects have received medication for
two months or longer. An evaluation will be available in February
March, 1973.

study

(2)

Naloxono panoate.

was completed

The dooc~duration of antagonism

in early September.

We

defined a

maximum

tion of 60 houra for 6 cc parenteral. A copy of the: report
sent to you, and submitted to Cliu. Phanm. Thckap.
(3)

Czclgggging.

Tho high dose

study

dura-

was

is continuing the

definition of eccoptability, tolerance, and duration of antagonism
to heroin. Ho ounnerircd the data of 20 mg oral, noting blockade
to 25 mg heroin for 72 hours. A copy of that report is oncloocd.
1639 (naltrcxone). ‘wn provided a protocol for the
and filed on IND application for the FDA on
compound
this
study
October 25. this was rcgintcrtd as received on Hovcnbcr 10. 1972.
Of

(4)

EH

Additional details of our aporetion were providod in your
extensive site~vioit of October 26.

-

�Alan Ramsay,

Hovonbcr 22, 1972

3.3.

You may

also be internscod in parallcl studios

now

rlsu in tho Division:

in prog-

a. _Digrcnogghino. H. at. enopnrating with the Citybeof
canHaw Yeti in datining annual toxicology studion. which should
platad by the and of tho your.
b. Lovonnthggzl, We conplctod a second study of lava—
uethadyl and confirmed our earlier rnport that‘ao :3 won effective
for 72 hours, allowing a t.i.w. dosage schedule.
Sincoraly yours,
Fink, 3.9.
Professor of Psychiatry

Max

MF:1g

ﬁne.

�</text>
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              <elementText elementTextId="53893">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>November 22, 1972

Sister Mary Janice Belen, R.S.M.
Administrator
St. Lawrence Hospital
1210 West Saginaw

Street

Lansing, Hichigan 48914
Dear

Sister

Mary:

Jack Ludatscher was an immigrant physician who joined our
1964 or 1965 as a resident in psychiatry. I knew him for
about a year before I left St. Louis.

staff in
in

some

He was

trained in clinical neurology
studies then in progress.
He was

and we used

his talents

I Eound him sincere, cooperative, and anxious to please.
treating our patients and was able to carry out

capable in

his reaponsibilities reliably.
for

I have no hesitation in recommending him for any position

which he

is

now

qualified.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

Ming

�</text>
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