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                    <text>731—689

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Jun. 13th,
Mr. L. R.

Hines.

ﬁatMnmLa

Nutley. Hui.

Roeho

1973

Inc. .

0711.0.

Dew Len,

hank you for your thoughtfulness in tending me
a copy of “The Benzodiaaomnes”. I have had a chance
to read-1t and ham found it no“ interacting. The
biochemistry of these compounds ht: wparently been
worked out in considerable detail. As you my know,
we are: now in the 31611; of an "ﬁxation of tha m‘
and behavioral effects or bmaem and diatom.
In this study we are mutating blood levels at variant
the»: and I am optimistin that an should be dale to
contribute to the understanding of the role of the
on hum function.
13mm amound and its
-

v

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mum
min. may thunk: for m thoughtfulness

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airman): yours,

Mu:

Fink, 1M).
of Psychiatry

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                    <text>%
',"1

Wygqu-w-v-

7383691

June 13th, 1973

Virgil A'o‘ Ph¢0g ”.D'I g.
President. Hediaal Atr:1rl.

V10:

‘

ALEA

Corporation‘

Boar

Virgil.

,

950 Page Mill Read.
9310 Alta, Cﬂifornil, 9530);.

I havu road the proposnl
antagoniut’with grott intcrtitw

tar

It

narcotic
;1:long-acting
a drtnntic ind

protonsignsl prcucnma$ion‘ The introduction 1:
toehnieully and losieally carruct - Sadned, your stuff
has done an excellent 36b in sttting the problau.

furtharnoro, the style of pretentgtton of clinioul
tanting in sodsta and apprayrintc to a preposal which 1:
rbcusned on the duvolopnnnt o! s dcvico. You indicate
:3 mittens»: or the importcnnc of clinieul testing. :nd
yet leave open tbr the contruetins usency to select it.
taut: of testing.

I ﬁbula be optimistic thnt should the committcos
be 10:10“: dbout this npproach, thcy ﬁbula conaiéor this
applieution favornhly. I would be pleased to tactic you
in nu:

that I can.
belt rugnrds.

way
my

Sinnnrcly yours.

ﬂux Fink, M.D.

Pratt-nor of Psychiatry

hill:

�</text>
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7383693

m-e—

«WW.am.

“m-‘m'ﬂn‘ﬂ’vwx.m~vv..,.v..w

June 13. 1973

Professor 2. Keohoulan.
Dept. o: Netursl Products,
Hebrew University or Jermain.

The School

9.0.

or Phermeey.

B. 12065,

Jerusalem. Israel.

Deer Rspheel .Both Al and

I

I were distressed by your letter of

may

30th.

letter of Her 10th indicating that you
in the States for s for days, but during thst time I
see in Mono. end therefore did not reach you. Your lster letter
is inaeed surprising, and I very much rep-at thst this sequence of
events hes mom-red. Ae you elresdy know. the Netionel Institute
of motel Heelth with snow widen“ he‘s finslly end reluetently
eased to maerteke s. program of. developer“: of e longnseting
sntsgonist. There ere new contract sppliestions, I on told.
end perhepe the eonittee will arrive at a. legion]. decision bssed
on the credentials supplied by the Northeastern poop.
I believe that Al will note some mention of your distress in
his next discussion with the people st
had rseeived your

would be

m.

m.

wit
It is of interest to use that may
experience
or interest in drug abuse have indeed cone into e field during
the pest two veers . end new with fine reputetions have written

moire great sppiieetions

which committees

,

st

m hsve funded.

I hove been saddened by these events. in yertieulsr b1 the menses
that new who heve come for monastery gain will probsbly contribute
little. Also. because there is so mob honey, science seems to
here been dieplsned by polities. Beosuss I here been becoming
increasingly Wfortsble in this environment . I have foenssad
more of w sttsntion on the problem of herein and behavior.
particularly with psychoactive substsnees . and put the drug sbuse
problem sside.

‘

Our studies of hashish users in Athens is going very well,
end Dr. Btethnis end his coworkers should have s creditable

doemnt demonstrating the leak of signitiosnt effect of chronic

..

- .—.

"mum-e...

�Pref. a. Micheal”:

~2-

June 13. 1973

Mill:
an. Ind 32: mm degree of tolerance to very high
doses of mush. (Men make 130 I; arm-mm equivalent
fam- tilu t «hr with plum. and without intmuption of their
par-fame).
I hope than will be tn opportmty to visit you in
(formula some time soon. In 1:11. m1}... should you cm
hack to the Unit.“ Stat.” plan In no km. and whap- to
em ”man to have dinner
My

bent--

”my“.

W3

Mum»
‘

”/13.

"

,:

yam-n,

Fink. 1M).
Fatwa: of thn’ary
lax?

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                    <text>7383-697

Juno
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Manley

FRO“:

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summer:

If

VA

“.13.

VA

aspen

Jacques

811m

projects:

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1973

r. 2011", NJ).

ﬁnk.

1913

For

link,

25, 197'! Jun:
m. Jammums.

or motto
Mutton
38K heave—115
25 . 1973

~

(h) Colloboroun “may of mm - Methadone.
VA oollohorotiw study, no additional
funds to dutc-

studio: mo innovativo tenements of opioto
aemdonco, portioulnrly substitution by methodone and
Tho

motto antagonism using avalanche.
using wpillopnphw, urinalysis,
tmtunt
hovo boon
heroin

lemon-swig and
Evolution: of
and

intrnmm

challenge-

introduced.

Project staff inclusion

Donna. Sun-on. M.B.B.8..
Don, 3.3.3.8.. and Julian Rubin. 14.1). or the
(6%) . undo:- tho supervision of tho principd

ﬂounder

me

24!.

investigator. It: Fink. n.9, . Prof-nor of
MY - Stony Brook and V4. consultant.

thiotry at

Dr. Pink hon boon appointed to the VA-BAODAP
Gallant-active LMH-Mothodono Study Coordimting Council;
and elected Prooidont, American Payohoyothologiool

nonunion.
VJ.
ill/1.3

To date. no publiootionn have been den-1nd from
"study program.

thin

�</text>
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                    <text>\.\

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opportmity to uncut- t maublo program. Please note
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and the it my not
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»

June 15th, 1973
Dr. Michael Boaubrun.
Department of Psychiatry,

University of West Indies.

.

Mane,- Kingeton, Jamaica.

Deer

nicked.

The studies in Athens are proceeding very well. The
hashish user sample has been studied. thoroughly; controls
have been identified and studied; mime investigation: using
inhalation of hashiah acne-«113.4 and marijuana have been
commend; and we are new proceeding with on acute
withdrawal study.
The

quality or the. work is. excellent and

we

on

confident that» are con docmnt a range or chronic. effects
for «mm: as well as clearly showing the development

of tolerance.

to confine the"
It he: become even more urgent
end
poyuletion in
your
emu.
an ideal case for this purpose. It bu been more then

oboemtiom in another

W

«amassed thitwork. and I am writing to enquire
new be “awaited; or perhaps you
them
under
other wepieee; or your interest
undertaking
an
has ironed. end that my further efforts Wild be of little
to
for your opinion
inﬁerut. I would be
mother it would be fruitml for us to attempt a. renegotiation
of our relationship and, the potent“). funding for this study
niece

we

whether

thou audios

mum

a

wow.

Meanwhile, we have heard tint some of the meteriel
from your first study he: been presented. and I would be
met grateful for eopiee of
report: or pinpoints which
oould be
at
to
this time. We would like
us
tunable
give due credit to year prior work in our forthcoming

m

presentations.

w

to

�D!"

mama. mubm
From

”19¢;th
13‘

~2~

June 15th, 1973

this lotmhud. you will act: that I have
inventory in Stony Brook. Tho Chaim

9:: a new

Stmlw Yell”, tho form 111mm:- or

and. his
W

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14.33.

Professor of Pay-emu”

�7383-68h

Jun.

161:

, 1973

Jam J. 30111:“. 8.1)..
Marcher. Btu-m 01’ Month Gunﬁre].
State a! Key fork Department of math
‘

Executive Division

mm Ava.
Albany. LY. 12266
81:5

'

ballistigr
{to ban appliéd far a emanation to outage in
T
Clan Basemh‘ and. instruction“ nativity using
sandals I watt-oiled MIMQS; We. submitted a. general
«mum of our man: with this invitation.
Bug: Dr,

In

melanin;

human“ of that application. we are
mm
copy or the work mutant“: for contract

a.

vhmh describes the ma.“ which is ongoing
Wenmus
gt. the want tins and for we}: we!) cartiﬂeﬂton 1a
remand. In Melitta-u m the unwitting a any: of
t form}. propoul for m: wk beginning Jun 25, 1973,
mm: is an Manama of mhzﬁvmns.
Sincerely your: ,

Pink. mm
It:
Protauor of

Psychintry

mm

m

a

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                    <text>WWW..ww—u

I

Tmﬁh

Juno 1h, 1973

23x. Egg-1

{mall .

Dirwtor or

Have ,

New Year}: NBC

M].

h.

News.
NtY.

Dew Earl,

m

I regret vary much- missing
tom. but I have
and
lecture
Boston.
Drugs
in
prior
I hope
cum
t
you enjoy your stay tony.
After a. numbcr or your: mm has issued a. manual
call for Moratorium to develop 3 long-acting memo
antagonist. New that the incidence of opiate use um
to M declining, u. main multimillion 6.911ch error: in

being launched. l’arhcpn it would be useful for thc
may methadone dependant pmonn tint new dot tho America:

“‘0‘”!
My

best with“.
85.11%me your: .

ﬂux

mm.

14.1).

Professor of Pnychigtry
gar/1.1

�</text>
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                    <text>N“
vv—x

‘

war-y,

7383696

June 15th, 1973

J. Greduoll.
Contract: Mhneaement Section,
Greats and Contracts Menngenent Breach.

Mr. R.

,

notional Inetituie of neutel Eeelth,

Perklewn Bldg.,

Room TC~26.

5600 Tiehere Lone,

RookVille, Herylend 20852.

RIP-ﬁnAe73—22S

Lita:

E. Tonlgz

Dear Mr. Gredwell,

Enclosed is a reviled contract pricing proposal for the
study of neltrexono in “The Evaluation of Narcotic Antagonists“
in response to R!P~EIMH~HDA~73~225. Thie revision is in the
enount or $165,761 for 18 month: end repreeente en exteneion

of
m

83M~h2~70-115.

In.ueking the adjustments requested in our telephone
conversation we have:

‘

F»:

deleted iteme representing EEG;
added e leboretory teohnioien

edditionel laboratory teete;

to: the

provided an ellouence for trexel for the four
edditionel deye each week for eubJeote to
extend the clinic daily while on outpatient

statue;

end. increeeed the nuree from heltbtine to
full~time to provide edditionel weekend

coverage for the added daily delivery of

neltrexone.

ﬁe underetend thet the ProJect Director bee ree¢umended
edanetnente in our permit. and we agree to comply vith his
reoounendetione, subject only to the review of our local COBIHB,
ehonld that be neeeeeery.
Thank you

for your eoogeretion.
Sincerely youre,

HF/i:

EMIe

MI!

rink,

McD.

Professor of Peyohietry

�</text>
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                  <elementText elementTextId="106721">
                    <text>mam
V

Bh-Emk

m 1m.

1913

m Much,

mi. (Irma,

0n,

Rolland.

Bur Bunk,

V

mam»

13'

wart,
unit{annotating
It”!!! of volm
m weedited
t
of the
the 03810313!
the

w

will»
Ia
u:mm mm but month. Than
wcmuian thethemoat
«a
auto-sate laments at our
rupmut
work.
whit-3h

by D». 11:11.

Milt-had in

0.

I trust then m mam.

It m

good

suing you in none.
Sincerely

ma ,

Pink. 13.13.
it:
Woun- or Psychiatry

mu
men

.

�</text>
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                    <text>mm arm "ammwmmm—w

"awn—w.“'wm«mh—nmnwrvmmuwmwm

7mm
June 15th,

1973

Dr. Vera. Rubin,

1080
New

Fifth

Ave. ,,

York. ILL

Door Doctor Rubin.
_

to divans: your study of
W roe-.11 that we are

few years ago we not
use in Jamaica. :You

A

sta
involved 1m parallel gum or the physiological
effects of

1133211311

in

Greece».

are «ﬁghting Our mum, om! I would be
grateful if we could be plum! on your mailing list for
any reports men are. or will soon be presented no that
we may (30331er the» in tho 'mluotton of our data.
‘39

Porouthotioally,

tint we have "on that
lament physiologic

now

chronic hashiah use (loos have

effects. we regret mu more our inability to carry
out a parallel study in Jamal“.

H best

personal

"Mu.
Bimrely your: ,
HI: Fink. Md).

*

‘

ml 13

Profeuor of Psychiatry

—

�</text>
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V

7383408
June 18th, 1973

Wham Traynor.

Ms .

55 West 70 Street.
ﬂew Ycrk. NJ. 10023.

.

DwBarbera,
35m:

very much regret. rewiring your letter or my
I
indicating ems. there might be
difﬁculties

the

at lthe Cornell installation. I heme ﬁnally moved gay whole
awaﬂon to Stony Brook. and am new in the proeeu of
reorganizing 2w laboratory. As my" cell to you a few month-

I will

need some help with the 1800. but;
best ‘tae
this . There are some
update programs which require professional help. but
as I understand from Donald, therein no urgency with
these. I am also interested in expending our programs.
ego suggestea,

am

not sure yet

how

We

em

Some time timing the
I should have a elm
of what I need, end would like to be able to :39th
you than. From yum- lettzer. I presume you would not be
Willing to come to m): at. Stony Brook to test out
programs, although I imagine you would prefer to do most
of year work in New lurk. Thank you for letting no knew.

11mg.

Ky

best raga-do.
Sineerely yours,

Me:

Pink,

24,1).

Profuaor of

m:

thutry

�</text>
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                    <text>Wu“

,

www-

.

‘W'r‘

ﬁavvlga-Pw‘v-‘P‘,

7333-707

June 18th, 1973

Ernst M11. 261.1}. g ‘1
Lafayette Clinic.
951 Lafayette East,
Deblo1t. Nichisan h8207.
Dear

Ernst,

It was

/“

to see you in Boston,

and I very much
next day, an trrival at my
laboratory, I was mat by the Ghuirunn or our departnnnt
who indieuted an inherent in tons new oquiynnnt for
tolcuctry of EEG signala. Rocsll1ng tn» many difr1cu1tion
we had in Missouri a few years ago, and recognin1ng that
your syntan 1: operat1onal, I would be grateful it you
could d1ctate a short not¢ ind1eat1ng the type of
equipment thst you now use, tho minufaeturer. and nodal
nuibert. Should yau have intornst1on of sons improvennntu
good

enjoyed our lunch.

The

that you would 11k: to reeommnnd. I would-be grateful.
roaommend your cyltcm, s1nao
I know that it is opcrutioatl. I would need. I believe,

nlthough my inclination 1- to

spacif1cntions for tha hegdset. d1polo receiver and

unplifior.

Should you need some upo¢1al help with thb ntutiltics
of your tegretol data. plans: don‘t hesitate to cull on

m.

Mhny

thanks.

my

best rognrdl.
Sincerely yours.

Fink. H.D.
Prafensor of Puyuhiatry
Mg:

HfliJ

�</text>
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                    <text>FNW'1'vxI3'V‘fav

u

.

m

r."

r

A

. W...

W

&lt;\

73SB~TO9

June 18th, 1973

Dania

rw—Wrwwnrrnwyu—ymxv

W0”, PhoDu,

A.

Eastern Pennsylvania Psyuhiatrie
'Henry Ave. and Abbottsfbrd Road.

Institute,

Philadelphia. Pennsylvnnia 19129.

-

.r

"u...

a“

1|

_

Don;

Sth

months ago I_wts yrupuring a review of

the
canditioning'hypothesis'for the etiology of opiatev
dependence and decided, at that t1m§,to report our
'attempts at using this mathbd for the treatment of
Ladicts.. In reviewing the duct. VB fauna that we had
failed to carry out an adequate test a: the conditioning
'hypOthesia and were left largely with naturalistic
data suggesting that tolerance to the_antagonist1c
effects of cyclaaocine‘does not occur; that the,drug
is safe and easy to adadnister; and that the means far
int adequate teat do indeed exist, but thgt it would
require some special effort.
'

«

,
v—mw

w

wyv

(nun—

“a."

'

y-uwv:

Had I attendea

bac&amp;unc

I

tn:

van detained

meeting

in Montreal

in Europe), I

(I did not

would have revicvwd

our exyeriénce and ntated that a test of the hypothesis
yet to be'dnne. There is, therefore. no manuscript
thst I can send you. save raports of our experiences
with cyclazocine - a capy of one of thus: is enclcsod.

was

An

my

a...

boat regards.
Sincerely yours,

w".l..-.__...—ng-

n...»

.n.

7—hwllﬁg‘

w-

Mn:

.mv

H...

:-

vw‘-«n.-,F.W..r-

Fink,

M.D.

PrOIEQnor of Psychiatry

u

ur/id
Enc.

-

\E\\

�</text>
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                  <elementText elementTextId="103779">
                    <text>TBSB~705

June 18th, 1973
Mr. Frank

J. Liaka,

Mbnagtr,
Corporate Data

&amp;

Informntion Services
Meeting).

(BIA Program Committee 8%!)

0.

saarle

D.

&amp;

P306 BOX 513.0,

00..

Chicago.

Illinoin

N” IQ“.

”5113,

"EEG

At

the

60680.

I

DEA moeting.
presented a
OHS Bioawuilnbility of Payohoootivo

1972

Indians of

mm

.

report

thereafter I gent a copy for publication
reports. and have not heard from the editor.
I am writing to enquire vhecher you have any
information regarding the publication of that report,
and should you not. porhapa you could direot no to the
aypropriate paraon to oaks an enquiry.
Drugs".

in the

Soon

BIA

Buoy

thanks.
Sinceroly yours.

Fink, M.D.
Professor of Psychiatry
Mix

MF/id

�</text>
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              <elementText elementTextId="56732">
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              <elementText elementTextId="56733">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>7383~?10

June 19th. 1973
Mr. Gary Boynr.

Center ibr Studies of Narcotic. and Drug Abuse,
Nutiaaal Intuitute of Mental Health,
5690

Fight?! Lane.

Knoxville, Maryland 20852.
Dear Mr. Boyer,
A: V! have discussed, w. are studying the effects
of unrijunnu inhalation in ahronia hashish “sure in
Athcna, Greece. undnr the ntudy pwogrwu 38M h2~70~98.
Our luﬁclt pw¢3e¢t, thrlnl;$eﬁ in conjunction with Dr.
Btnvt saarn of HIMH,1¢ : study ef’th¢ errant. or scuxe
withdrawal in those nan. Boasuua we ﬁbula like to limit
the tint If snaking, and haeanao than: man have a high
auarec of toleranoc such thni thay achiave noun satisfaction
only when they htvo snakod 120~180 as equivalent TEC-A-9
hashiah,¢r unrisuaaa. we are reqnnnting n supply of mnriJunna

vith a high aoneontration of wao~A—9. Ehia will permit us
to have ﬁns subjects snake within a 20 minute smoking

period and coneeatrntn our behavioral and phyliolosieul
observation: under’gontrullcd eanditioas.

I an enelaning a BNDD order for: 2220 far 500 grnas
nuriaunnt (2.5} wﬁcmbp9‘oqnivnlont). It in my intention
to trannship those ta tn: university of Athena under an
‘import permit that Dr. Stefania has recoivud. and with an
export license which I an requesting eoncurrent with this

letter undar
Iehedule I).

my BxDD

rogiatration

PF0100759

(exporter,

ihank you very much for your gocperation.

Bingercly yours.

Fink’ ”.90
m
Profousor of Psychiatry
MF/iJ
En” ‘

�</text>
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              <elementText elementTextId="56722">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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          <element elementId="44">
            <name>Language</name>
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                    <text>aw“

‘

‘vw

:‘vI'W-‘r

V

7383-716

Jun. 19th,
To:

Stanley 1. 20110:,

PROM:

Max

SUBJECT:

Equipngnﬁ '-~

I
(1)

-

(2)

-

wuuld

Fink,

24.1).

1973

M.Ds

'

like to’recammsnd two items:

1‘H?-h§lAdwuaeed‘Seicntifta Pocket Calculator 0 $395.
1 Hewlett Puahnrd

series 9800,

:Fragr-Innblg Calculgtor
Kbyboard

11222A
112%3A

autumn“

'

User Definnhlo

mum.»

h,9?5

_

aytion:

1122114

Model 20

'

ROM

$1385

(wry)

885
222

1.195
$6.170

To upmgrlde

this instrumant to

tho tailoring:

Peripherals:
9860A
9366A
9862A
9865A

u ninicompuxor would roquirc

Ihrk snug om: Reader

Tharnnl Printar

new»

Tape Csuscttc

$850

2.975
2,675

1.

0

8.290
$1h,h20

Th1: in equivalent to d DEC .3311 proeeusor. hovuvcr, 3nd
should you with all the appendix-a. 3 DEC may be better.
M7/13

�</text>
                  </elementText>
                </elementTextContainer>
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            </elementContainer>
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        </elementSetContainer>
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    </fileContainer>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
            <elementTextContainer>
              <elementText elementTextId="56710">
                <text>The Max Fink Collection</text>
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            <name>Description</name>
            <description>An account of the resource</description>
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          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="56712">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            <name>Source</name>
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  <item itemId="5670" public="1" featured="0">
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                    <text>nan-111
June 19th. 1973
Dr.

0mm

sum“.

Profane: of, Pawn-am.
Univmity or Athenn School a! modicum.
mutton 301911;]...
Av. .
7h,v»1111u13

Athena.- (Ix-«cc.

Wu

6mm;

new

an m
mum.

Inaﬂtuta
1mm by the Human
of 1mm Bum: that they :10
1m. 2.5:! mew-‘9
I m "gunning 11b to be shipped to.” today
and at. the.
that
"quantum a. BBB!) export permit.
1113 my emanation ﬁlm; I would in" most or this
I-

m

mama w1th1n

a

1m

mks sad uhould than be able to
Iphntoshipthcu’aerinlundoryour

two

“lantern;
import 11mm 12km. u I luv: requested 500 grun-

mat many.

emnabit (mum) from the $1.8.
tha Inﬂow Insututo of mm Knuth.

My best regards.
8111mm}: you".

in: ﬂak.

14.1).

Protcuor of Psychiatry
20/13
nun.

v.3. I awn manned. eh“): (1271. awed April 10. 1973.
Eneloué 1: n rmlncmnt for this chock. It you find
the M13111“, plan ants-u}.

�7383-700

Juno 15th, 1973

Costa: Stefanie, $1.1)...
Prof-nor of Psychiatry.
University of Athena school of Medicine.
Egiuition Eoopim.
'

'

’

Th, Vuillissie sophiee Ave...
Athens; Greece.

Denr Cootes ,

I very mach enjoyed our visit and was very much
impressed by the extent and quelity of the work that you

end your

usocieten have

done...

Enclosed is a review of the budgetary allowances,
mount mid to date. end the muse. to the end of
the your. It in peninihle to Water fun!- from one
category to mother except that equipment my not he
bought and that travel expenditwre: my not wooed the
snowmen given.

m

I

have spoken to Dr. Euro about the high concentration
At first. he felt that huhioh should he used.
but after noon discussion we earned that a. high dose
would be eoooptehle. I called Mr. Boyer, who
is responsible for the
suppliel. one! he is checking

mum.
mum

m

the availability of e high oooteutntion. Meanwhile,he
hes not you ho edditionel bottles or 3. 8% marijuana
using; your import certificate 121310 ma on export licenee
from 31m. .1 m to can hin'oorly'nez'b wok end'if higher

oonoentretion euppliu can he obtained he will get them.
if thou
is unnotisi'hotory. perhaps you could check with Dr. Miro:
wont 0, supply or high comentrotion heohioh.

In the nonwhile you should cheek tho 1.85; and

Baywatch, I on sending you the outputs vhioh I
failed to bring with M. on well us an melyoie of e mic
depressive patient which Ton “keel u to do for him.

�60.“! MGM'.
tom .g.
u
v11}.
sheets.

N‘D‘o

we

'

3733. 15311, 1973

“*2“

mm obtained the nautical data.

as
all
m an.
new iron, some other mans. that. I should do m
I smz attend to than in the coming week. For. the
VG

do:

tn. may.“ 1n due-mud. as

ruin! the yam-mks.“

W119. what with“.

’

Sincerely yours,

Max Fink: .1 Mob.

Profs-gar o: Psychtwry

W13

he

0

.-

�Wm"

..

,

,

,

,

.‘7'm'mvmm-I

6/12/73
I

at

E

* aubco

tr

.

000: ~ haagggugg;

.

a. stipgnaa
1).

Ow

,.

$88.hoo

Volunteer. fees

12.300

a. Eonp1t¢;1x&amp;$;on

gggg

'

1,850

a. TQlcphane..§ostugc.

t2 hzlzzg

gagggce

to 12[§;[13

$56,151

$31.6h9

10.3%

1 ,9h6

o

1.850

600

no

560

7,000

:u,soo

2.500

3.330

2,112

3.310

1.690

1,620

328

3.593

1.680

15.300

$77,135

$603136

'

a.
§

Lab. gnnlysis:

r. Mitcrinl
3.

EEG

&amp;

A

suppaiés

rooording

h. Travel

,

.

3.921

.

1. Consultation. services 16.980

‘

1,&amp;18

yaw

my.

Uzlwqm-‘ruv

”WM

Wm

$0M

$137,391

»

,

mm

�7M73
May

17th,

1973

Cantu Stet-min. BM). .
Professor of Psychiatry.
University of Athens School of medicine.
Esinition Hospital,
73;, Vu‘illiui: Sophia

mm. arms.
Dear

in.

coat»,
I bare ma: arrangement! to

win in Nahum

mmreservation
to stay at the
I

from
have made

Britta“.

a.

on Tuesday afternoon. June 5th, and

should

Grand
meet
with
like to
you either
time during the max: two days.

that evening. or my
I should like to be able to review the data. which
Iwinbebrinsingvithmvithmmdym
”mitten; the subcontmt era-anion; and to work

with

m in planning the 1711;116:3311 ﬂaw.
I

to Maven Sun to 1:911 him
we written
be. in
I
became he has

the time

ﬂat will

Rhona,

bun particularly interested in tho next phase of
the grow. Should. ho be (bin to Join In. it
mm b. no.1: nimble, and I have extended tn
invitation to him.
I look forward to suing you.
ﬂy

best regards,
Sincerely yours,
Mu Fink. 11.1).
Professor of

10/13

thhm

�7313-651

April 2'! , 1973‘

Cetus Stefania, 1a.». .
Minna University Mica]. School,
Department of Paychictry.
Eginition Homitcl,
Th,

Vuiliuic

Athens, Greece.

Scrphics Av. .

Dar Cantu.
Whenever

I sit cad think of writing ta you the pomlcr
- "Is wane listening, in anyone there?" comes

song tron ’1776'
to mind.

Bumtcly, I

mm

have sent. by cis- c

muse

containing c

statistical prom-m cm! a tape which contains thou
on cmn tracks at the appropriate 3P1.

mun-.1 or

ham: been naked. to com to Wuhington on My 2nd to
mgotiatc the «tension of the contract. I an naming that
with your
the tuna raw-tea in our letter at MI: 15th
We

gnu-07:1, and
which

we

will

do our

at
but to 0min full upprcvcli

I an enclosing a cow c: c

all:

macaw

you about the status or our

given m by Rhea

emulation.

for m to ruin the progress of the but
nice the men-cry plums far the continuation
of the data of this
phuc and the
interesting cm. Should you with to cm to the United States
within the cm nix nooks, I mid be and to work with you hora.
mama this not be feasible, I would then suggest that you let
an knew what is 011311311 for you. sad I will try to com to Ail-3cm.

cmmlc

It

in

bar

but

few math: and to
of that withdrawal

W

regards.
aim-arch

mu ,

ﬂak.
m
weaves." Director
111.1).

90/11

M.

�~3__(,..1.

.n.

,3...

,W‘WF.

731-5568
Marah

5th.

1973

Dr. Costa: H. Stefania,
Athena Uhivcrsity medical School,

Dcparﬂnnat of Psychiatry.

Eginition ﬁalpital,
7h, Vasilissin Banking Avo..
Athcnl. Greene.
Dear Goat‘s.

cro progrouuing very well with tho EEG datg.
Banana: of sum: (haunt raeordn. v3 hswe don: the
regression aanlysea on 16 tubaecta, and this soon: to
be adoqunte to givv u: scan data far tho differences
bctuaan the variaun aonditiona. The bohaviornl data
which Rhos brought back with her has been coded and
aorrol&amp;tians between tha EEG and the bahnwiornl
intbrmation or. nuv 1n progrcta ~ sons having bcan
aompletud during the lust few days.
Rb

callcd Wishiagton on a number of
occasions during the ptnt wusk. but v. an not have
any more infbrmnkion. It I do not have a clear renponte
by uhruh 10th. I will «all, and it that. is no anlvor
by the 15th, I will @311 you. A copy at Khan's report
ta In which V: have tile&amp; with Dr. ssara is enclosed.
Khan has

my aoeountant hAs been over the receipt: uhiah
Rhea.brought with nor. This dacumentation in adequate.
Enclosed is our shock for tbs fbur inwaieeu of January 6th.

In order to obtain :n export license, 1% 1:
naecisary to file a whole act of docunants - which I did
on March

lat.

Rho: came bank must onthnnltstic rcgnrding the
canton: of tho work,'us 1311 as tho cooyerntion which
aha receivud. Mhny thanks.
my

best rognrdl.
Sincerely yours,

Fink, M.D.
Exacutive Directer

Max

Kilt:
ﬁnes.

�731-5131

February 13%, 1973

Castes Stefania, M;D.,
Prefeeeer of Psychiatry,
University of Athene School or medicine,
...

”mm.

,
.v

a.

Eginltien Hospital,
Th,

veeillieele Sophie: Av.,

Athens, Greece.

.v.,,.,.

T
.
v

.
..

:

Deer Castes,

4!!1;'4':~I

«rip

w,

van."

WW

Enclosed are cheeks-1n the emeunt at $13,365 to cover the
aeleriee for April-June. 1972 end catchermbeeember, 1972. I
will need the eencelled check: the these eeleriee as well as
the ones issued for Jhly~8epteeber.
Copies of the expense vouehere for $l,lho are also

necessary.

I em returning the other veueher requests and eat that
these be rendone. I have made suggestions on each, which.v111
ellaw me to meet the reqplrenente of the auditors.

first

Xon should knew thet in our
year. we were ellewed
some overhead for the expenses in Greece, end should there have
been dieelleweneee, we could
been on these funds. Since
June as. 1972 we next been lenied en overhead allowance. we

fell

eoneldered cancelling the eentrect hue cur interest in the
study impelled us to eecept e bed contreet. (Indeed, if I were
not personally involved, the Directors veuld have rejected
washingeen'e offer). To protect my Boerd, we must have adequate

reeerde.

You will reeell thee you rejected direet payment of your
personnel, using netlonel pride and year need to relete to the
start as levers. I eeeepmed your with. as I accepted the HIMB
deeend for e nn-overheed eontreet, to aeeeeplieh the mission.
sue. the rink to the Aeeoeietion in too greet end unless we
obteln adequate statements. eheeke, ete.. we cennet continue this

eontreet.
with

I

An

Rhee

will tell you, I em too fetigued with contesting
e threat of lee: of money fer ee little gain that

EIMH, end

unenthneiestic about continuing the eontreet utter June 25.
I have applied to RIEE for en exteneien, no es not to
Jeopardiee your chances. end will endeavor to support these
em

1973.

�Goat” Stefania,

$.13.

«Eu

Inﬁrmary

studies. but your coaperstion is critical

mutants

1:5

the financial

Sincerely yours,

Max

new/1.3

Emu .

\r
w
-«v-

,.
..

v.;—~:e~,m—v-;m«,um‘

my:

«'1va

r

w-wrm-qw-m

.,
,.

1973

mutation of the interacts of my associates.
briefed and will try ta amplify the“

and in thc

Rhea has been

issues.

..

lot,

Fink,

M.D.

�--wwrcmx7.-L

&lt;

731-51111

deruary lat.

1973

Castle Stethnis, M.D..
Protasnor of Psychiatry,
Uhdersity of Athans school or Medicine.

Rainition Hospital,

7h, Visilliauis Sephiaa Av.,
Athens, Greece.
Duar Cactus.

Rhea, Vbita, and

I hsvc read your

I

35

summary

report. and found

or intarost and significanca. Vb raviawud «gen 0: the
seetians and an: comments and auggeationa have been noted.by Rhea
who will review these with you in Athans. My own antes, which
she will amplity, are attached.
much

hnwn ankud

with ynu.

bar

rcviav the relieving technical issues

(1) The report has been aunt to Dr. Rdbcrt Petersen.iﬁ§wgl

I balieve the data is sufficient far thalr review

r.

and dacision no ta
any eontinnttion qr «xtenaion. While x hawk rumindad than of cur
agreement, I am not sanguine thnt they will be dble er willing to
umvm.w1th any slacrity; and vauld suggegt that. shauld yau wish to
eontinua this interaating tyye of work, that alternate sources of
anymort be sought. I huva diaeusseé than: with Rho: and she is
prepared to assist you.

(2) Bath the raport in August and this report taka little
cagnisanoe of the contributian at my unneeiates tn the studios.
Recognition of eontribntions is always a delicate issue and when
w! discussed this in Copanhagan, I trusted to yaur Judgement to
protect tha interest: or the staffs invulvmd. This report seamed
dafiaiant in this regard and I hawu made sumo amenanants, whiah I
trust £411 much your approval.
(3)

we have redunea

all the

EEG

cage: by perioa analysis, and

huvu 16 sﬁbaocts camplete with 5 cxparimontn each. The initial
proeessing has been done using our linaar rugreaaion analysis model.
The drug eonditions are distinguidhdhle tram placdbo, in patterns
similar to that reparted'by Vblawka and Dorubush in their earlier
studias in v.3. voluntaers a&amp; lower doses. The analysis was done.
including ﬁhn post-smoking period and the postnteating EEG in a
single analysis. A: the varidhility is high postuteating. additiannl

analyses are in prograaa using a quadratia regression modal, for
the firnt pastanmoking period. In aﬂdition, we are aarrying out
sums npacial analysas to amplify the changes in the alpha bands.

�Coatee Stefenis, M.D.

February let, 1973

~2—

These date should be complete in two weeks. we would like
to undertake correlative studies, of the EEG, heert rate, eelr~
reports, and some task performance data. volevke has used e
"forced regression" analysis model for our heroin and cannabis
date with success, and'we propose some similar studies here.
Rhee has e list of subjects and date which we will need to carry
out these analyses.
'

(h) Ae‘I hawe written to RINK and discussed with you. the
findings of these studies are of considerable interest and we must
give thought to both the mode one time of presentation. we have
dieoueeed the question end Rhee will discuss the enclosed
memorandum of our suggestions, and hopefully we can outline e

set of steps which one

needs.

eeooumodete our mutual

contributions and

Rhee is bringing the battery you requestea, es well as some
cannabis materiel. On her return, we would like to send samples
of heehieh, and residual marijuana end THC»A~9 to NIMH for assay,
end I would appreciate your making these small samples available.

(5) The initial threat for this study was the observation
elowing reported by Professor Mites. The EEG records of
the heehieh smokers were examined by h neurologists, and the controls
by 2.‘ But, a critical reviewer could argue that the obaervers
knew which records came from beehieh smokers and which from controls.
Perhaps, it would be worth the effort and coat to code the 60~7o
reoorde end ship these to an independent, experienced

of

EEG

electroencephalographer of known reputetion.for a detailed report?
Rhee has some suggestions for candidates in the v.3. and Europe.
.

(6) There are problems

in our book~keeping thick is of the

following nature. The auditor: will require "belk— ups" thet the
salaries were paid as specified; and that the expenses for
supplies were paid. I believe you are depositing our check and
issuing your checks for the expenses. I need the processed check
or its coyy for salaries; one the bills with checks for other
expenses. It cash, your initials or one or your staff certifying
e eeeh payment should be eatiefeotory.
Again, my congratulations on e fine report and my best regards
to Adele and your eeeooietee. I look forward to seeing you soon.

Sincerely yours,

.yr/ia

Mix

Fink,

M.D.

�gaggestions for Presenﬁatian
A; Se

ate

1. (a)

A

(b)

A

Re

social, madleal, neurological aummnry of the two
population sampler. with emphasis on the soainl
characteristics, snaking history, work and family
charactariatica. Ineluaing a hiatary of the sample.
Stefania. Boulousouris. Gefou, Liakos
description of thc undieal aspects ~ phyaiaal
examination, mantal status, EEG (clinical), Echa»
EEG, pulmonary.

ﬁvefanis, Linnea.

Tam,

etc.

‘2. Psychalogical Characteristics of the two populations 9

I.Q..

W118

subtext:

and pwofile, mamory

Darnbush. Kbkkavi

tasks.

3. Acute Experiments

(a) Ensign, goals, dosages used, with type: of psychiatria
response, esse deseriptiona.
Btefunin. Boulougouris, Dorﬁbuah

(b)

and heart rate; relatinna to each other
gal! ratings; tolerance?

EEG

Vblavkn. Tam, Fink

(c) Paychologieal

&amp;

and

to

stetania

teat datagw , pupils. etc.

Kbkkevi, Listen. Dordbush

h. Tolaranne Duvelopmant: latﬁer to
Fink, stafanis
5.

B.

A

1.

EEG

JAMA.

eftaots (brain effects) of chronic hashish
to editor.
Stefania. Tom, F1nk,Vb1awka

~

letter

siggéc Vblgag

int

t

History or atuﬁy; Alma.
ﬂank

2. Ghamintry or hashish; history of hashiah uaa in Greece;
hiatcry of sample.
Mirna

�n

m&lt;

‘5».

suggestions far Preaontation (Continuga) * 2

of users
Idcntificaﬁion

3. (a) Sample
390131

Mhdieal

Heurophysiolagical
Psychologieal

Seton

Goran

Gefau
Liakos

Tom, Vblnwku

Kbkkevi, Dorﬁbush

(b) Sample fbr control

Stefania

(a)

Stefania

Camparisona

h. Acute Experiments

(a) Goala, design

Stefania and Fink

(b) History; methods; aescription
of subJects; aropwouts

Stefania

smoking times.

«A

behawior.

My

rim

intarticw

n.

WWW

(c) Prychologicsl

tasks.

"0....va

an,

(d)

EEG,

and perfarmnnce

heart rate.

Dorﬁbuﬂh and Kbkkavi
Tan and Vblnvka

uKWI—rl‘w?

(9) Chamistry of substaneas.

Miraa

(r) Significance fbr drugs,

Fink, Stefania

mm

rr-Irw

Jar-WW";

WW.

”my

a...“

-my

mmY’w-‘Kx—w—a

«menwrrlr

u

«

warn-pr:

-——.-

v

r

.n'"

tolerance, interactions at
comgonents.

5.‘W1thdrtral Experimmnta.

atefunis

�15

antrgl«85g§1e

”

,

Egblﬂ’

..~

.
r;

'

why ware patients admitted to hospitals?
Any relation in tins to smoking hashiah?

c

A.

-.—

.M‘

there differencal 1n tgﬁes at Jabs?
factors eould contribute to tha difference
in two groups in rnta umployed?

Employed: ware

.,.V

.A

What

all-,m.

v

,...

Should E30 racords be rdviewod by independant
EEG'ar using coded records?

.

P
A

.

e.

n

'g‘

~

differences are troublesome.
they reflect effects of drug use, they vuuld

The 8TH and “£18

If

.~.,n..-A-n-

rcflect brain ahangea

&lt;n.‘-_.

differcnees? If nut.

~

do vn have

how much weight

given to these solitary findings?

H

-

”gym”

2

3%..

a!

nge g;:

8-

other

"

is to be

tannea
The aneeaotal stamanents dbout #7

are important

roflaatioas of tolerance. ﬂow long does it take
the men ta develop tolarance? This man ware he
to be tested again. could give an idea (antuming
ha is using hashiah).
not an analysis or aovnrianca ha a better
model, since aubaeets differ widely as to starting
levola? (toe Diagram II - page 33). This in clear
in diagrams IV and V, where dose effects and initial

Would

level

seam

to interact.

aritienl graph refleota one of the principal
effect: of eannabis. If the grayh 13 correct 78 mg
TKO a; marijuana has a great an effect as 160 mg
This
THC

as hashiah.

What

are the significant

i !D
Aua&gt;c&gt;n
The heart rnta effcet ulna
relationships?

(or)

A

n

B

C

parsistn for much longer
than anticipatad. Are A, B, and/or 0 still &gt; D
at 10, 15, 20 minumen postwbreak (3 75 minutes poat~
smoking).

Ara

these to be intoryrotad ta the result of

not drug related?

RV

and

�Quastiona (Continnad)

-

2

TEE content. To vhnt extant
what thqy wnre getting?
(or
guess)
did
Are that. data sufficiently consistent or reliable
to allow name canaecturea that aalfwrating is related
to dosa cf THCwA—Q while heart rate is not?

5g;_8elf ratings fallow our
aubjanma knaw

51;.Hhat is "fault index"?

hE.

to interpret these as drug effect at 30‘ and
practice affact (or loss of drug effect) at 70‘? acre.
too. response is related to EH6 content.
Are we

:9. Data far grineludaﬁ. Is
wall?

it

available for other tests as

6. Behavioral responses scam most marked in a 2:?
subjects: ho, an. In 2h, 35. 38, and El thnre in a
raaponae to placebo as «:11 I: there any alum in personality
or amount of smoking done in an and ho to relate to the
sevare raaponse?
.

�‘

(mentions (Continued)

A.

-

3

5118'.

B.

@@

Cl
1).
I

E.

�Contigued Sggngrt

Manner,

1. Ford,

2. Greek funds
3. IBM

*'

m,

Howard Enamels. Dreyfus.

- unassis.

"80¢

Suggest Stefania and Mira: deeide if study is worthwhile and,
plan to approaah founaations with these pilot data.
7,”,

&lt;._

”yr”.

,
~09».er

If

he niches v.8. intervention, nocda an agreement between
Dornbush (who will have to go to agencies) and himself;
or ?rcedmnnd and Dornbush.
‘

Jam

Suggast project leave
3 your support.

NINE

and seek more "indepandent" and

��W

.F—

‘7"

‘

’

RoberW’PéterseﬁTPh—U.
Chief, Center for Studies of Narcotic and Drug Abuse
Nationalinstitute—of—ﬂenﬁﬂetlth-~—~w~—~ v
5600 Fishers Lande

“a

_

W

,VﬁchgvilleArﬂand
Dear Bob:

M

NW

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to

W

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.5742

THC ~

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3’6

$2.?

_.__

~

W

VA‘

7—“

elaboration of the characteristics of the control population
and detailed comparison with hashish smokerswill be the subject
{m
of the January 15 progress report.

_Ar_1

[7441 WWW
36 J-Zé
W

——

M __4H

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7—

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28

WWW

_

7

cgntrols. A deiaihiféﬁﬂﬁmﬂimmmiﬂshnserimsincludei_ WWWin the report sent to you in August. Thus this paper represents the addition
of/ controls which were absent at that~—‘time.
v"_—i——”_
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AW M‘nw"
‘

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WW

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se’rﬁ
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matérial
We are enclosing t“I¢¢£¢$¢fHitti/ﬂh‘ﬂﬂﬂﬁﬂéﬂﬂ##1## This represents
i~~ «Ms
October 15th
the
This report ‘1‘!“ includes a summary comparison of hashish users and

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                    <text>J-«u‘tz‘wn— 4-3.;

.-

-3-: anus—w:

w" «7- :;v «ems-:1&gt;rmn~r1xv¢wxrs

.

£,\‘.'Nl‘,:

Wrsc-I

‘

,

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,

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“ma-z xymmxawvmﬁwu.

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-

~:»)--v(-."§‘-

M
7383-712

June 19th. 1973
Dr; Richard Abrlas,
132 Columbia Heights;

Brooklyn, N.Y‘
Dear max,

I‘do not rceull whatnot

the rcport

v. ova-rod rdprints or

from Cbmprchcnoivn Pbyahtatry.
noun, 1 would ayprcaiate ten copica.:x
.

It yuu

-

-"

htvc

I

Enelasod in a.ruprintvrc§u¢st aeht by one of my
friends. I tn also enclosing A roqngat fran.Joc Zhbin

fur tha other paper

and

it

-I

glue Isak reprints of this one

you haw. any I.wou1d apprcciato 10 copies.

.

I

Mhny

thanks.
my

best regards,
Sincerely yours.‘

”I! Fink. Hm.
Professor of Paychintry
MF/iJ

h¢.

o

n

.wgun

:

‘

V

....1:.~;

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April 27. 1973
Mr. John R.

Coxsolino.

Harootio Investigator,

Suffolk County Health Dept.,
Eonpitol Affairs Division,
Route #113,

Rivorloizh Avo.,
Bimb.“ , Ho 1 a
Door Kr. Coozolino,

I rogrot that I nova had to cull you. The
enclosed letter from tho BHDD invottigntor indicates
that BHDD is unwilling to provide the necessary
registration until the State rogiutrotion hos been
completed.

Thank you

for your cooperation.
anooroly yours,

Pink, M.D.
Professor of Payohiztry
Mu:
Mir/1.1

Eno.

�</text>
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June 19th, 1973

CORIQ

-

DOW g; thietg
'

.

June 15. 1973
The Depertnentel 003188

net in the litter-7 st

11. OD emu; Dre. 8. Mex-lie, E. Rubinstein and H. Fink

(mm).

project "Effects of Televieion on Children's
Prosociel Behavior" we discussed. The Committee wee
eeeured thet the rink to the subjects we minim. In
e. dimeion of the permit. the
Cmittee suede the
1.

The

following suggestions:

(e) the study by limited t9 children with
went: rether then then with a. guardian;
(b) the sentence

."1'

he" been

informed about

the other deteils of the stw to w
estiefeetion” was «ended to "I heve been
informed stout the deteile of the etw as
provided in the ettsohed description"
(Pumphe 2 end 3 o: the deeeription of
the pro ect should be suede eveileble tea the
-.

perente ;

(c)

it see suggested thet the lest sentence not
proviae the 91m“ "to defrey incidents].
costs" but that it specify the complete tee
to be peid for pertieipetion.

The Committee vee eesured by Dr. Rubinstein that the
videotepe of the subjects would not be shown publiely, end

thet this usurenee

m edded to the torn «knitted end

signed by Dr. Rubinstein.
With

these

unmat- the proposal wee

sprroved.

�The domino: discuss“ the potential source of
2.
other project: and indium that 11: would bu willing to
review all pmjoata curring tho «Mum's mprmtw,

should

the Genius: be requested.
The Comittu adjourned at 12.10 pan.

Ht!

nut.

Chaim

MW 5.3

“the

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                    <text>731~Tlh

Juno 19th. 197 3

Chad

th

Bunk,
22 Green Aroma,
(but Hock, 3.2.

Gentleman,

Pluto «noel

out on bum:
amount of $2.500.

made

cheek 01211

and April
14.13;

of Coat“ Btofmiu,

10, 1973.

in the

sincerely you".
Fink. 15.2).
m
Executive Director
149/13

�</text>
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                    <text>v

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June 22nd, 1973
Mr. Richard Duffy.

monarch Mahatma of the State or

P.0.

Box 7126,

“hm.

Kit.

How

York.

12221..

Ref:

ﬁlm—104;: (Mention)

Door no. Duffy,

but month we outﬁtted an extension request to
RM for the ongoing study "Evolution of Eutectic
Antagonists". In nomt’istionn with than we hove agreed
on tho fouoving hudgotu-y diocttionn for the 18mm
period, Juno 25,

1973

to Mambo: 31.

Salutes
Ringo beneﬁt:
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191M

$82,800

13 .9011
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hso
10.500
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$806

Supplies

$162,287

separately, {on will ho making from W. Ernut
(301- ha—hlST) I copy of tho contmt to ho
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the
by
“and
contract he returmd to Wuhinaton prior to noon hid”.

T013107

Juno

at

of

mmom.

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you

516-hhh—2hh7).
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for your ooopcrotion.

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                    <text>«r.

Wrr‘wi’I—v'

7333—723

June 213t. 1973
George Gerdos. R.D..
Boston State Hospital,
Boston, Mesa. 0212h.
Dear George;

I have read your paper "Low Dose Thiothixens in Chronic
Bohisophrenia" with much interest, and have a few comments
shout the issues that meet interest as.
The

references to the

effects appear to he incomplete.
olerify whet the study
record shows that the heheviorel changes
EEG

and are put in a context ihieh does not

eon-unicetee to

me.

The

that the dropout rate was high. There were few
differences in clinical effects betveen the low and high dose
thiothixsne groups. In yartieularl this reflects a very'high
dropout rate. The significant changes vere a reduction in

were small and

aneooperstivenoss with high dose, and a decrease in depression
with low dose.

It is imwortant to note that concurrent with these linited
differences in behavior, there were smell but defined difference:
in BIG. Kore, too, the level of significance was low. largely
because of the e-all sample. But you could safely report that
high dose thiothixene elicited a lower average frequency.
reflecting an increase in theta and alpha activity, and a
decrease in beta activity (Table 8. 888 report revised 2/12/73).
Should you.ooneider the behavioral data of significance.
I believe you ought to report the EEG data of equal
significance. for the high doses did elicit KEG Ghansss of the
anti hotie class. according to my classification (and that or
Itil
. Low doses did not prodnds say evidence of stimulation
(defined as increased bets. increased variability and decreased
ssplituds), lo the extent that you wish to use these
observations. I would conclude that the hypothesis that low doses
yrodues stimulation is not supported.

than

�George Gerdoe, M.D.

1913

psychoactive drugs. Theee observatione with high dose
showing smell ehengee - inereeeee in that: end
elphe eetivity. which eeeonmenied.behewiore1 improvement in
some yetiente end e reduction in nneooperetiveneee — 1e
eoneietent with our general hypothesis of the eeeooietion of
236 end behavior in nan.

\

the questions that we tried to enewer wee whither
differed in their initial BEE eherenterietiee.
When we eeeeeeed the EEG eherenterietiee or the eubjeete et
the end or placebo with those et the end of low done. we found
no eignirioent differences, which led ue to conclude that the
eleplee were honogeneoue at the outeet. In your analysis or the
hehewiorel date. I mien this ennlywie, It is not clear whether
covariance wee e technique epplied to your ante. which would
enlwer my question; or whether none other teete for homogeneity
prior to treetnent were introduced. I mention this because
yen'preeent the beheviorel ante (your Table 2) in terms of
poet eooree only, and I believe the reader is entitled to know
whether these differences are releted to initial poeition.
the

Amont

two groan:

it

Since you eent me the original. I en.returning
to
an interesting retort end with the enell enendnente
which I suggeet, I would encourege its publication‘
you.

It ie

we've-e regards.
Sincerely yours.

we: Pink, M.D.

Profeeeor or Peyohietry

,nu

i

Zlet.

thiothixene

w-«ww:

”wan-

June

It: neny year: I have been eeeking to nnderetnnd the
relationship between EEG ehencee end behavioral ehenaee with

nu.

w-nwr—m

'-2—

Illid
nee.

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                    <text>mama.

mm mm.

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Plus. «natal».
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                    <text>7....

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June 21st, 1973

I. Boyd.
Aecoxmting Department,

be; June:

Gnu Imtrmnt

WW.
Bur

W30

Cm,

021690

Mr. Boyd,

I received your letter of Jun: 8th. “around
to no at w femur institmsion. New York Medical 0011930.
Payment will be ad: sufollm:
Invoice l38001w, $68.55. in! 33er received on
5/29/73. and payment will be made by the ﬂew York
Medical Confess by June 30th.
'

Balmce of 1min: for shipping EEG paper. 8181;.35.
Ind not requested payment for thin. as I had not
received a. statement. I have requested for a. check to be
inn-d by the New York
Collage. md this should be
vithin tho nut pay period ending July 31“.
ant to

we

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mm.

If eitbar 0: than accounts: are not paid by Jun
plane call or write to an gt my new addrou above.
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                    <text>was

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                    <text>73813-722

June 2181;, 1973
Dr. 1.. Image,

Department of Neurology,

Central ﬁddle-ox Hoapitsl.

Park Royal.

London, HALIO. Engllnd.

Dear Leo.

as

a. pleasure meeting you in 088, and the
It
time of our got—togather
an too short. I must
say again hm: impressed I on with your progress in
settim up a. study unit. We are new determining the'
dosage of amitriptylim. I Just received the (EB—~93:
this week and should begin w studios during; July.
,

-

I

am

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writing boosuao

Mort,

a.

’

vary close friend. Dr.

W

prwticing psychologist from our
is on his any to
for his bonds”.
omnity.
no is s longtime sufferer with s homisted lumbar disc
,
sud hos suffered surgery. He has bud a recurrence
“sonny, sad is new: in sons p.113. This is sufficient
to mks him feel mooﬂorta'ble, but insufficient to
keep his from his bonds” He sskod my advice so to
tho
of a neurologist that ho might see in one he
hsd difficulty. and I have taken the liberty or giving
his
at Central landless: Hospital. Should
ho can. you, I would be mtsful for why assistance
th'st you may xiv-s his.
Melvin

a

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'0' best rowan.

812:“:st

yours .I

m nut. "09‘

Professor of Psychistry
Ill/1.1

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                    <text>June 22nd. 1973
Hr. H. 8. Vellum.

1:10..
northern-m
07110.
Nutley,

NJ.

mam,

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Eula-ed. in e list or the blood eeuplee delivered
on Friday to your office. You will note
cue «elm
inﬂate: the drug alas (1, 2. 3) end mother
aw
drug code. reflecting e tendon augment. I indicated to
Dr.
that em or the tubes bed erected; tint we
bed need different tube: far different
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the» blood mlee. but can ewe you thee should the
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                    <text>WM

-..,——~

7V.w—nrw-

“.m.

.v. ._\.-r

m 7w“.—

..m

.

"an. :Wv‘ilYIVK"-w-;—y"'l."’

.34.-..1-..‘ Van—.wwi—WW.»

nuq—

.-

June 22, 1973

ﬁartin Kits, Ph.D.
Clinical Reseerch Branch
Rational Institute of Mental ﬁeslth
5600 Fishers Lane
Rockville, Hsrylend 20852
Dear Martin,

Enclosed are copies of three suumsries of the sections of
the conference on the psychobiology of convulsive therapy. and an
introduction, as submitted to the Archives gg,aenersl ggzggigggz
for the consideration of the editors. These copies are undergoing sole
editing for the volume, end as soon as that is completed. I will
submit final copies for your official use. For the meanwhile, these
represent the principal texts end should be available for your consideration.
The volune is edited. but there are large sections. partic«
ularly in the summaries that require some sore work. I have undertaken
these myself and should here the sort completed by early July» Should
I asst that schedule, the volule will be of! the press in Hovsiher.
The publisher has indicated his desire to withhold final delivery untill
January 2 in order to have s 197k publicstion dots.

Again, I sent

during this effort.

I

am

to thenk you for your support

sending a duplicete

Have a

pleasant and

set to

and consideration

Dr. Schuyler as you requested.

hepuy summer.

Sincerely yours,

Mex

ml
cc: Dr.

D.

schuyler,

HIKE

Fink,

14.9.

,,

_

..

_,.

.

,M

.

~u,

�</text>
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                    <text>Deer Bonne and Doris,

I went to thank you for your cooperation in obtaining
the blood samples in our recent studies at NYMC. I am enclosing
e token payment with the urge that you buy eonethins for yourself.
Should you be out

I hope the work in New
this wey, please come

my

regards and

my

York continues
and visit.

to be rewarding.

thanks.
Sincerely yours.
Me:

Ma

Senna Durbin &amp; Dorie Giordano
York Medical College

New

Pink,

M.D.

�</text>
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                  <elementText elementTextId="103771">
                    <text>rwvam

;

E

ww-w w—‘r‘

V

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x «nu-mn—

A

---7..;..

rmvﬁhymm.
.

.

v

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.

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,

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av-.

m. n'vw'mr .Vm ‘w'w-m/Hm

www‘u m m-wr
.

731:11hGr
Dr . T .

Penioutopolie

Eginition Hoepitel
Athens, Greece
Deer Tom,

Enclosed is the output of your tape and a summery page. We
beck with each condition as if it were a separate experiment.

played it
There are two outputs, one before 'ertefacting' and one after. The
base period is the first, eyes closed sample. You will note, by checking
the number of samples ertefected, that our staff thought too neny samples
in the eyes open record.were not of cerebral origin, and therefore the
significance of this piece is low.
The eyes open

big differences
must

be left to

record is interesting, there being

in the two samples obtained on dqye
your clinical acumen.

l

and 2.

many

The meaning

I trust this review is helpful.
Athens and I
It was run discussing the project with you inwith
to
soon
visit
you. Good
another
have
opportunity
I
hope that will
withdrawal
the
study.
luck in

Sincerely yours,

Max

Pink.

M.D.

7.. “mm...

v-..-w.-,—... r.—

�</text>
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              <elementText elementTextId="56543">
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                    <text>733:11503'

June 25, 1973
Dr. T. van Lierop

H.V. Orgenon

Ose, Holland

Deer van Lierop,

I have had the opportunity to check one of the coded tepee using
the decoder. we at first hsd much difficulty but were eble, by cerefully
adjusting gains, to echieve the samples enclosed. Tﬁe decoder is very
sensitive end we have to edauet the seine on the tspe recorder very

csrefully.

if they reflect the
tape, it would be helpful if you‘vould advise us how to
reed this code, for our record purposes in indicating the samples which
we may have to reject; end in noting the onset end end of different
code on the

Please check the enclosed samples, and

records.

We have received the couples or GB-9h end ere in the
of
establishing our own doeege schedule {hr enitriptyline
process
hefbre examining the GB-9h.

Thank you

for your help.
Sincerely yours.
Me:

Pink.

M.D.

�</text>
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                    <text>TBIzllTGr

June 26, 1973
Costaa Stefanie, K.D.
Department of Psychiatry

Bginition Hospital
Th,

Vasillisais

Athens, Greece

Bophiae Av.

Dear Coetaa,
from the acute
administration: of cannabis to the chronic hashish usere, and will
proceed immediately to the analyses of these data, and their correlations
We

with the

EEG

have received the

additional data

materiel previously analyzed.

would he most helpful to the proJect to have Dr. Linton
work with us in Rev York. During my recent visit, I was impressed with
his knowledge of the details of the experiments, and as the analyses
will become increasingly necessary to evaluate each
proceed.

It

it

analysis before proceeding with the next. with this View in mind. I
an hereby extending an invitation on behalf of the Association for
Dr. Liakos to visit with us for a hunter of weeks during July.
Separately, I am enclosing a direct invitation for his use.

Steve Basra called on Friday to tell no that the supplies
of high concentration THC- marijuana were inadequate fer our use; and
offered a supply of hashiah of high THC concentration. There are some
details that have to be clarified, and I have been in daily communication
with him. As soon as the material in available, I will call you.

of

Dr.

I look forvard to your visit later in the year. and that
Liakoa next month. I am confident that we will be able to carry

out the analyses as
My

we

discussed.

'

beet regards.
Sincerely yours,
Max

Fink.

M.D.

Executive Director

�</text>
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                    <text>731: llBGr

June 26, 1973
Dr. A! Liakos, M.D.
Department of Psychiatry
University of Athens School or Medicine

Eginition Hospital

Vasilliesia Sophia:

7h,

Athena , Greece

Av.

Dear Dr. Liakos.

It gives me great pleasure to extend an invitation on
behalf of the Asaociation for you to visit our laboratories in July.
We are aware of your contribution to the ongoing study of Chronic
Hashiah veers in Greece under contract 38M h2—70—98 with the ch.
National Institute of Mental Health.
We have received the additional data tron the acute
studies undertaken this spring. and in our analyses, it would be most
helpful to have your collaboration and advice as each of the analyses
7

are completed.

Should it be advisable, we will provide funds for your
stay in the United States; and we will reimburse the Department of
Psychiatry for your travel expenses.

I look forward to greeting you in the U.S. I will be
available in New York during July and most of August, and can be reached
at my office (5164M 2%?) or not home (516—2166 5mm).
My beat regards to Professor Stethnie and to your Vite.
Sincerely yours,
Max

Fink.

M.D.

Executive Director

�</text>
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,.,.-

‘

...

,.--V_.,, .M..."

.

,

...,,v_,,.

W

_

W.ti...

,_,

.,..J,._,

1

'q

a“

".7

_._ v-".,
, u..-—— ,, mam-wan1?“:

V_._...‘_,

Wye-.m—_,u—ra

,.

7

7

&lt;

_.__..
,

‘

7.,m". x V.
7

. v»

,

.- _, w.~vw-'\I

,,_,_.

27 June 1973

8. F. Yolles, H.D./Che1rneu, Department of Psychiatry

rink, M.D./Cheirnen, Research

Committee

FROM :

M.

SUBJECT:

Ayplicetion fbr Chart Review. Fermingville by S.J. London, 0.8.W.
reqpeste permission to examine patient records at the
Fermingville aftercare unit of 0.1.8.3.. to determine the eweilebility
of subjects tbr e doctoral thesis at H.Y.U. Be is interested in the
role prior hospitalization has on re-hoepitalisetion, particularly the

Mr. London

impact of "patient role" has on edduntnent to tumily and

to

community.

request: permission to exemine records; to use the date to prepare
e preponel fer review by Professor Whiter Heft end a committee er
5.241.; and to resubmit the final propose]. (1t reuible) for review.

He

Permission for chart review ahould be grented.

mrznpv

w r.-. “my..r...,_,_v

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,er ,..a

�</text>
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                    <text>7:383:72?

Jan. 28,
Mr. Gary Boy-r

Cantor for Studio: of

Hotioul Institute of
5600 Fishers Lon.

Knoxville.

mm

1973

lunatic a Drug
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Door Mr. Boyer,

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“my thanks for your ooopontion.
Sincerely roar- ,

Mu Pink, 24.».

Professor of Psychiatry

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28 , 1973

Kttt, Ph.D.
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Martin

Dear

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Pink, NJ).
m
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June 29. 1973
Murray Weiner, M.D.

Merrill Laboratories
Amity Road

Cincinnati,

Ohio

h5215

Dear Murray,

I am enclosing two reports which I have completed
the
recently, which reflect the thinking and experience withEEG
mthoda
classification of psychoactive drugs using quantitative
in volunteers. The March 23 report was presented at a symposium
on phase I pharmacology; the other report is a short summary and is
included because it presents additional tables, particularly Table 5.

profile for known
antihistaminics in interesting, particularly if there is an active
compund which has different CHB4behavicral effects. You will note
in the report reference to the difference in EEG classilication
The problem

of defining

an

EEG

to dextroamphetamine- compounds with
anorexigenic activity vith contrasting behavioral effects.
I will try to work up a small protocol for your review
and should send it to you shortly.

of fenfluramine

when compared

Thank you

for the question.

My

best regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

max

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                    <text>7383-602

April and,

19T3

Paul de Been, Inc..
Drug Infernation Servieee,

g

E

11 West Forﬁyweeeond 8%.,

5

R“ York, Eff.

i

10636.

Dear Doctor do Been.

I have checked the {ands eveildble to

eouins year. and find that I
year eerviae.

am

me

for the

unable to subscribe to

I have found it

most valuable an&amp; I wish to
onee 15313 to: providing the scientific
community with date which he: been most invalusble for

congratulate you
»~

Me

Sincerely yours,

a

‘

Mb:

Fink.

M.D.

Fvofeeeor of Psychiatry

lav/13

�yawla’e We.

(212) 564-6560

Jew/0.

DRUG INFORMATION SERVICES

11

TO

New York

WEST FORTY-SECOND STREET. NEW YORK. N.Y. 10036

Medical College

Fifth Ave. Hosps
Fifth Ave. at 106th St.
Flower

New

8:

York,

NY

10029

one

3/22/73

mvouca No '

6189

YOUR ORDER NO.

de Haen DRUGS IN USE INDEX CARDS, 1973

[1] Annual Subscription

For Shipment To :

Dr . Max Fink

Dept. of Psychiatry
5

East lO2nd. St.

New

ar

- Psychiatric Edition

York ,

NY

10029

- 8th Fl.

$150.00

�</text>
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                    <text>7383.605

Dr. Jannthnn Cole.
Boston state Hospital.
Benton, than. 0212b.

Dear Jon,

or

I an available for the

313%.

or June

In the

A??A

13%.

Couneil on may 30th,

liat of people invited,

Donald Klein havn baen emitted.

Kenry

Brill and

Aloe. unless ynurar Jerry are assuming full
rcaponsibility for the arrangaments, you might wish to
invite whomever is assisting you for tha arrangamanta
aanmittee. should you think it necessary.

Sincerely yours,

Max

yink,

M.D.

Professor of Psychiatry
MP/id

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                    <text>735-603:

April 2nd. 1973

HMS? ﬁnch”. xii-Do.
Chairman. Research Gawain”,
Vatarm multratmn Hospital.
Northpcu‘t, 13.2.

Dear Doctor Walter.

to treat apiata Madam:
of the principal therapeutic modalities
availabla to us - ”Wont maintenance am! meatie antagonists
(cyclawcina).
As you know. we have: begun

Mama with two

Methadone Manama requires the daily administration
of methadone. This is both an expansive procedure for the
patiant and for nanny, and man an additional apaeial risk
tint drug given far
days my M: 9016., lost, stolen.
or inadvertently be fatal to non-dependent aubgeata.

$.me

moat modiﬁcation of mathadona maintenance ha: been
the use of a longer acting opiate, lmathadyl. In my
laboratory in Her ram. we have been ramnaibla far am a!
the principal m1; Mel: has dmatratod that levmthadyl
in doses batman 70 and 100 as can be given three times a wok,
roa- it provides aroumwlarama for varied. in excess or 72 hours
(indeed, our parent experiment it tho aduiniatratian of 100 mg
twiaa weakly. and w are most satisfied with the unless).
I m mm»; to propose the transfer of patients who are now on
in our outwtiant mega-am, and who have Men stabilized
mum”
for We months a: long“. from lanthanum to lmthadyl. Under
praaaxm governmental regulations , this 1: faaaibla under IR!) 6590.
Ono

Ihava'boanadviaadhym. E. Gardnarortharoodandm
Ammunition that notiﬁcation that we are carrying out the
study at ﬁlm Vatm mmtmtion 303mm will be accepted
by him. and such natiﬁeatian has been tent as him an Marat: 29th.
Fer your records. I m use melanin; a ccpy of tha protooal
vhieh the original “M1” ware done; and copies or three
rapeﬂmhiah «scribe our mime. The ﬁrst amen in

m

W

JAMA May

appear

8. 1912: and

current

thlatria

for months.

"

ma

ascend 15 in pron, in JAM, and
vault-a and a amry report. for
Than-ariaswhich should swear within 1:124: and:
than

“thin thc nut eight

�g!

,

E

.z

sunny maker. um.

‘

mum
m- Hgtiond Institute of

'

mm

~2—

2114,

1973

of Znulphs—cca‘hylmthtdol (mun)

Mal

no available mm
South. and hue shady bum

Waited with our pursuant.
I mmomwﬂl alsobaploandtakmthnt the“
a.
cox-unto.

ma 1: uranium
«“1311st manhunt“
m
ﬂatten 136.9331: thmtuhm the antics far the annual
causation at IWWJ. 1n opiate mama. It. 1: our
he imlmd in this
duh tint we will
«hm.
VA

T:

»

'
'

3

Q...

imam

«mam

1: tantalum to porn“
I trust that this
our previous aubuiuion far the clinical
max-m of «ammonia! and ”Mac. A: vs are ready to

gamut“ to mad

m

uncut: m, I
amount; notification of thin
mm
convenience.
at
mlili'k
mm m
would

smartly

,1

”H

‘

4%

yours.

mum.x.n.
Profoum- at Paychn‘bry

�</text>
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-~

""ra-V—

—-'w'~'-‘

738B:079

~

very“:

‘W‘Wr

:‘
m

April 2, 1973

‘

'v',v~’~'

&lt;~m~nw-mvw_waw-rwu.

\3w1"v‘ww'nr"rr.)w

fry-v

r“

v-.-

v

v

Stephen Keaton, M.D.

Greeellnde Hospital

Valhelle.

Rev York 10595

Dear Dr. Keaton,
Thank you for your kind invitation to participate in
the weekly grand rounds of the Department at Grasslands. I
regret that I will be unable to take part during the next few months,
as I already have an impossible schedule. I have moved my
laboratories from the city to Stony Brook and the transition
will not be complete until the early summer.

Should you wish, I would be pleased to

the fall.

participate in

r~mw~wrwwmw~a~wrw~wm

Sincerely yours,
W

wry-nvanwan-pmmwmwwarer-wwmmww

‘w'nm'

n
w

"1'

urr’vwww‘“

w
n:

“mm-v

r-v

'ww-e:

mum

.mp-

Fink, M.D.
Professor of Psychiatry

Mex

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                    <text>7333603~

April 2nd, 1973

Professor: E. Eﬁnkel

and 0. Doloe,
Medisinieohe Hoohsehnle Hennover.
Abteiluns {ﬁr Elia, Neurophysiologie and Exp. Heurologie.
3000 Hennover~xleete1d,
Khrldwiechert~A11ee 9,
Gerunny.

Door Profeeaore Kﬁnkel and Doloe,

I receivod your kind invitation to participate in the
in 197%. The ides 1e tiaoly end I look forward to
perticiyeting.
The outline augment: that near intereete V111 be diseuneedz
the technical problems of date acquisition, reduotion of EEG
and etetietloel pwooeeeing, equiouent (particularly oomgutere).
GEAR

end «polioetions. Bone tonnes. soon :3 eoqnieition, date radiation
and elolyuie. are similar for all projecte. But the epolioetion
or these nethodn differ widely, whether the subjects are men or
eniuele. Shoold the eonferenoe focus on issues both in men and
in animals. I fear that your wish for a “smell" conference vill
be unfulfilled. I autumn that your primary interest is in the

application of these

methods

to studios in

men.

As you know, my eseooietes not I established a ldboretory
for oomguter ennlylit of EEG in St. Louis in 1963, and a second
one in New York in 1967. We next been interested for these men:
your: in upgaying the methods of oooputer ennlynie to different
problem: in peyohophernnoolosy. at now use our methods to
obtain the neuron uiologie grortle of new oompounde (phase I
peyohopharneoology ; and to moeeure the bioevnildbility (neuro~
physiolosio equivalence) of different formulations of payohotropio
drugs. By these methods we hero studied clinically accepted
compounds. preeuned compounds. and such eeoterio topics on
eenndbie, opiates and their antagonists, and induced ueieuree (BOT).
we but. devotea much tine to many technical issues. as the
different analytio yoogrene (power spectre, period eaelyeie.
maplitude integration, vuridbility meeluree), the problems of
the tangle 01:0. etetiatioe (univnriete versus multivariate,
regression vorlun dinerininete function) eta.

�Profs.

H. Kinkel and G. Dulce

~2~

April 2nd. 1973

the provisional aniline. I an pleasad to recommend a
at pines: whare we might honiribute to the grogrnml

From

anubnr

2.1 Camparixon or power spectral dcnuitz, /!‘riod
analysihlund amplitude analyait.
3:2 Proeaaaing EEG data ” statistical applicutions.
’

3.1 (3.5)
‘3.6

EKG

EEG

clansifioaiion or psyehhnetive drugs.

analysia.

h.3 and k.h The

ta

\\

DEC

-

IBM

1800

statistical

PD? 12 (and PD?

15).

package; aonvornion

come at thhne technical subjeats
presented, I would recaanand that you invite my coworhar of many
years. Bunmld M. shapiro,rD.B¢., fur his knowledge of camputer
method: as applied to EEG. (Ha has programmed the IBM 1710,
1800, and 360/ho; also DECi'PDP 12 and 15).

should run wish to have

Alaq’Dr. Shapiro and I havn been instrumantal in estdhlishing
a laborahary for EEG analysis at N. V. Orgauon in 03s. Bollnnd.
Their oomgutor director, James Porsak, had programmnd an IBM
system in Detroit, and is reiponaihle far programming the PD? 15
in 033. He is very knawiodsahla dbcut lacuna in Sectiaha 1, 2
and h at your outline, and I caauend him highly.

I am taking the liberty of onelosing a few raprinxa from
this laboratory which mny‘be rclevant ta your pragrsm. As you
will find, the bolt is that which is at yet unpublished. and I
ma dhle only to send you yrcprints.

I command yen for undertaking such tn arganiaationalgthsk,
I look forward to tho CEAN acutingn with great anticipation.
I thank yau for yhur invitation and trust that I will hnvc an
apportunity to diseual this with you on can or my trips to Europe
and

in tha farthhcning months.
my

best regards.
Sincerely'ynnrn,

Fink, Md).
Professor of Paynhiatry
Max

MF/iJ

Each.

/

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                    <text>7SSB~600

April and.

1973’

Bbeknreller University Mbthaﬂcne Dita Syntau,

York Ave.
New

snd'ééth Street.

York. 351. 10021.

Gentlemen,
Following the advice of Mr. Anthany Caglioatro, v0
are writing to request partioipatien of the Drug Dependenae
Treatmant Center at the Vitornns Aduinintrution Hospital,
Northport, H.Y. in the Rockefcllor Uhivnrnity Mbthndane Data

System. Ebrthport VA Hospital in a DQan'a Committee lonpitul,
and this program is opertted undar the professional nuparviaion
at the Dopartnnnt of Psychiatry at this university. we
believe that such participation will comply with the existing
regulations regarding reporting of our patients receiving
mathadonc.

fbr

Vb

an

would approciatc your adviae an

to ynrtieipate.

to the steps necessary

Sinaoroly yours.

Mix Fink. M.D.
Profcsnor of Psychiatry

MF/ij

ca.

Mr. Anthony

Gaslioatre

�</text>
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To:

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SUBJECT:

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I.

The "EEG und Human Psyebaphnrnaaology" protocol
submitted earlicr specified that uﬁbjcetu must be 21 years
of age or oldar. In ﬁhn event tact thcrc is any othar

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an» English lungungn of thc consent
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critical suggestions of

turn. I
that the runnindor of tha rbrm mutt: with the critical approval
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                    <text>nib-607

‘pril

W

M6518!!!”

y.

Program Head,

2nd. 1973

HOD. .

Early Clinical Drug Evoluntion Unit.
Psychophamoology Research Branch.
Rational Institute of Mental Health.
5600 Fishers Leno,

nockvillo,

Maryland 20852.

Dear Tom,
Enclosed is a short abstract of the presentation
which I plan to make at the May 25th annual mom meeting.

I think the program is fine. Should it be ponible.
be batter accepted no
following that of David Nargulen. rather than following
the two teohniool, statistical. highly sophisticated report:

I think the presentation vould

of

Mike Free and John

Overall.

Sincerely yours.

Mix Fink, M.D.
Bxetutivu Direotor

m/1.1
’

C

�</text>
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                    <text>731-605

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April 2nd, 1973

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University or California,

Irvine. California...

Mr Jim,

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now

volm is

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for reviewing

awry.

am or ﬁne edited
mmriyu
mats, your contribution

or the:

amlate.
or three ml].

are two
contereme it:

loose ends, but our

for chucking
most
volume.
the proofs for the
I an
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worked.
with
opportunity or having
you. for yam onthuniasa
and good spirit throughout this cndamror.

work from

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best personal regards.

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                  <elementText elementTextId="106696">
                    <text>..;

,
.7

.
-

7325-606

April and, 1973

SW

Katy. um. .
Premium of Psychiatry.

Harvard Median school.
Massachusetts General Boapuul,

Fruit street.

Boston, Mass. 0212!».

.
v

...

.,V

.
.

..

Dear

Squaw.

v

V.

‘

1,,

.

.7“,

.
‘

._

"w,

I

have met Larry m-l'bam and found him personable,
and cooperative. I think. it will be a
Magma-e doing “amines: «with him. All the doom“
but We have been some ta him.
for the summary
far the section on Chemistry. your work for this project
is complete.

madame,

mm

W best regards .

wqu.u~;,,.—,.m,,..,&lt;,.‘

1-

sincerely yours ,

WWW,

ﬁnk.
m
Enautive Director
MOD.

30/13

�</text>
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                    <text>Tssnéoh

April 5th.
Mr. Michael R.

19T3

aonnenreiah.

Executivn Dircetor.

Rational Commissien on Mnrihuans and Drug Abuse,
801 19th Street H.W..

Wishington, 0.0. 20006.
Dear Mr. aonnanreich,

I have reeaivnd.your nuaarandun regnrding tha
rastrietion on publication of the report on nnrcotic
antagonists which I Iuhnittca to the Commission.
In thn .1: annthc nine: thgt raport was written,
a number of papcra have appeared vhiah would auguont
that rcport and make it more timnly. If it is still
possible, I would 11kg to sﬁhnit an uycated report. The
uydating would serve prinnipally to ingrovo tho
axility or the docunsnt ‘3 a reference aaurce. It will
not ahange the Commission's conclusions, with which,
incidsntally. I agree.

If it

1: possiblo to

umsnd

the text. please

call my office (arou soda 516, hhh-zhhv) and I will
set Q copy to yum within three days.
Sinscrely yours,

Fink, M.D.
Professor of Psychiatry

Mtx

MF/iJ

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                    <text>.._

,._.,,.,..

V

w.

.,

.7

_.

.

ca,

79......"

a ,,.,

., -.
.u- ., -, “H

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.

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wmx—r a.

.1»:

.-

731:08lﬂr

April 5, 1973
Costaa Stefanie, M.D.
Universety of Athens
Athens , Greece
Dear Costas,
March has passed and despite many communications between
my office and NINE, I believe we are in the same position we

were in a year ago, I am writing to acquaint you with the facts
and to ask your guidance as to what should be done, if anything.
Our summary

report

was

sent at the end of January. Dr.

Snare apparently teed it and asked some questions, which we
answered. He also enquired about the budget, which we answered.
We next heard that the request would be reviewed by
a committee,
and then last week we heard that the committee had given its
qualified approval, with a weak endorsement.

I called the contracting officer to get his advice,
that no further negotiation was possible until he
received a detailed contract proposal from 'progran'. He expected
such a proposal in a few weeks, and then he would consider when
he could get to this negotiation, "there being more than 800
contracts to be negotiated".
When

he answered

I believe the stag! at NIMH are as little interested now
that the only movement will occur near the end of
the year, in June.
as before, and

options: to assume the contract will be
that you will be assured only about June 25;
or to indicate that extension is not requested and plan to
end in June. I hesitate to recommend since either course
may be painful. But I believe you should advise me as to what
is in your best interests, and if possible, I will try to work
with you and NIMH toward that goal.
You have two

—

extended, and

My

best regards.
Sincerely yours,
Max

P.S.

If I fail to

+415“: +0.

Fink,

M.D.

hear from you by mid April, I will allow

“an" .vl‘L--..l.

m7

4h+nvercn+4nm

cuf&lt;LL bYTan

�</text>
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                    <text>4.1;:urrwn2sr-vra.

731:08h1

April 7. 1973
Mr. G.C. Kunzman
IBM

59 Maiden Lane

Haw

York City

Dear Mr. Khnzman,

Enclosed

of invoice

is our check in the

amount of 8&amp;8.00

in

paymont

BKBTThT.

Please note that this organization is taxrexempt; the
appropriote records are on file with your organisation.
Sincerely yours.

4?.z,éyn
NIX Pink. “.3.
4

W

�</text>
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                    <text>,7, M.7-.r.,,.

.

I. ,9...“

.

V. ....

W... .. Vuwmm—r
,_

~ar

Y-

.,

.m-w

unm-w—rwr—z 9m

"MW":

-.'--~'1

"“5""

“WW"

‘ ‘-

"‘~

‘

"‘ "A" ‘7‘"

'

" "“

‘

73I:086EC

April 8, 1973
Mr. Lawrence Erlbaum

V.ﬁ. Winston &amp; Sons
1511 K Street N.W.
Washington, D.C. 20005
Dear Mr. Erlbaum,

Enclosed are a number of items: the corrected versions of
the papers by Fink, DYElie, end Volevko; two new reports (number:
21 and 22) by Kety and MoGeugh; edited pages 1 and 2 of the
paper by Ottoason (01h); end a discussion by Ottoeson to follow
paper number 1 (Fink).

I have made the correction: requested by the editor in red.
Note the comments vith regard to ’leucotomw'.'grend mal'; the desire
to use italics in my report; and a few other suggestions.
At present, there are two reports lacking: an overall summary
(paper 20) and an introduction. I shell do what I cen to get these

to

you

shortly.

Incidentally, I found your editor thorough.
many

m’

v";

thanks.
Sincerely yours,
“‘3’.

":5 ﬂ

Max

my

,.

u;&gt;

v
.

”“7”.”

r'.

.

:

‘(

',.-'

Fink,

-‘

"1':

M.D.

�</text>
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                    <text>7338-6215

April 9th. 1973
Jonathun 0. Cole, Md). ,

ﬂecretary,

Boston

APPA,

state anpitsl.

"

Ex
.

Beaten, Haas. Galen.

_

\

‘Y

Dear Jonathan,

I mot Dave banner at a. meeting on Wednesday,
and. he asked whtther we had «:11de on a hotel and

the dates for the APPA meeting. I told him that
I thought these would bar deemed ut the Council
heating; but untieipnting that occuien, would it
be possible to have the mbeomittco when the
necessary enquiries?

I note Fritz WWW acceptance at Warship
A: for reimbursement
for travel, I bane" this 1: upmprh‘be, and it
Dan Klein comm. hits ahould bu renamed.
1n

the Pnblieatim Omittoo.

Simarely your: ,
Fink,
m
Profunor of Psychiatry
£4.13.

Hflié

�</text>
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                    <text>rm”,

;

TBI~609

April 9th. 1973
Hr. Arnold Cantor,
P.O. Box 325.
Paranoia. 3.1. 10571.
Dear Arnold,

Enclosed is a copy of the inventory of equipmant
of tho Intarnationol Associaoion. an of April 1, 1973.
Ital: 1000-1003 are at tho atria. of the Ansocintion,
39 Arleigh Road; itana 100h~1133 are at the State Uhivnrsity
of How York at Stony Brook; and items llhhullTﬁ are at
the new York Mkdical College (5 East 102nd 8%.). The
items at the state University of Row York include tho
oomyutor installation and most of the technioal oquipmont.

rgo_‘!.$

—.'

Nagy...“

,Wl"!f‘}¢‘

:
”(new

while most of the itous can ho considered ”sol:innured". it would be prudent to obtain covorago against

tire,

wator damage and vandalism for the
1022-1059).

(um

IBM

1800

syttcn

I am also tnolouing abounonta from the New York
Mbdical Collogo describing the transfer of the oqnipmnnt

to tho Association; the relevant chapter: of tho HEW
grant. ndninistrution manual (chapter 1-h10); the grant
award for MR 2&amp;020 which includes $16,500 for renovation
of space far this oqnipnont: and an dbatrnot from

Newsletter (volumo 10, nudbor 2) dated February,
19?3. which nonworo tout quoations regarding the transfer
of equipment. These documents have been revievod by Hr.
Joshua Vogel. our legal noviaor, and it was hidgopinion
that legal title has boon transferred to tho Anabeiation.
and that V! should do all things which would be prudent
for tho maintenance and protection of the oqnipmont.
NIH DEG

Thank you

for your assistance.
sincerely yours.
Max

Fink, H.D.

Encouiive Director

MP/id

co.

Mr. Joanna vogel

Enos.

�</text>
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9

‘MWAVWZV‘LW’W‘fqPY

;
‘

.yywvfu:

A

&lt;~,.q.w_...v,v

pm-cmwvmvw

7383~606

April 9th, 1973

Dr. Abba J. Khttin,
Dupartnnnt of Me41e1.no,
Tulsa» University Schnal
1h30 Tulane AV...
E” 0:10.133, hub 703.12.

at thieino,

Dear Abba,

I had a very ploauant time in Raw arleans. and
an lorry to hlVl aissod you. Enelolud is a copy of

my

filing of an

now

A:

umandmnnt

to

IND

8569.

I interpret the rclavant regulutions,

undertake this study.
Good

you may

luak.
Sincerely yours.

Pink. “OD.
m
Professor of Psychiatry
M7713

Enc.

ca. Dr.

K. van Hiczon

�</text>
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                    <text>11'1-‘07-1?“

xx»

Ir’Z’ulﬁ'

~

'grlw

73I~605

April 9th, 1973
Dr. Ehrtin Kata,
Clinieal Eesoareh Branch.
National Institute of th$a1 Health.
5600 Fisher; Lane.

Roekville, Mhrylanﬂ 20352.

Ba: Mﬂlﬁﬁélnﬂﬁ

Dear Murcia,

I am vriting to roqucst an axtonsion withnut
additional funds tar £815561~93 to Deeedhcr 318%, 1973.
The present projnct period and! Mhy 313%. 1973.
An"

1'15““

zxx-wu'ﬁw

m:-

:v»

-.

‘-‘.'W",m"g-‘i'1'2;‘h€

As you knaw, V! have completed.mnst at the clinical
studies under this grant. and during the past raw annths
used seas of thn funds to complete tbs «valuations sud
regatta in support of that progoct. An extension fbr
tho rauninﬁnr at this yam: will permit us to complete
the vurk in accordance with our original dcsign.
Mung

'7‘”

I

W.

thanks.

‘
‘

sincerely ycurs.

megawmgazmrrm

Mnx

Fink,

M.D.

Principal Invustignter

Approved

Thunders 5} Isr321.

Presidant

HF/id

Jr.

�</text>
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                    <text>7333~61h

April 9th, 1973

ﬁr. Michaal

Box

lhll,

R. Knﬁyp,

Trinity College,

Hartford, Conn. 06106.

Dear mr. Knapp,

It

13

difficult at this point to be sure that I

have an opening this tummar. I vauld like to madt
you. however, and am writing to suggent that ycu get
in touch with Pat and arrangc to visit him. It will
be useful for you ta know what his work has been, and
if it is still of interest to you, arrange to meet as.
I am,usually in New York city on wbdnesdayn. If your
schooling does not pmrmit you to came during the next
few weeks. I will be glad to see you at my home in
Great Neck over a weekend.

.
my

If”

an

‘v-

7-

M‘WY

aincerely yours,

a"

ﬁwﬂwi

:
v7!“

Fink, M.D.
Professor of Psychiatry

Hhx

ﬁ¥l13

«W

�</text>
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                    <text>.v.

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7361383

April 9th, 1973

Jenn 81mm, 3m”
Missouri Inititute of Psychiatry.
shoe Arsenal Street.
m6 631”:

5%.

W‘,

Ben-

3m.

have read the paper "Acute Behavioral Effects
of Doxepm, Immine- and mum”. While the
clinical material is quite good, I believe 1:11: EEG
12

alumna

to

with you.
My

come

I have given

to Peter: and
as ”have had a.
it.
some
to
conclusions, I will be in tench

should be updated.
asked him to reviw

As soon

a.

copy

best regards to Susan.
Sinceraly ymn's .

ﬂu: mm, 24.3).
Profassor of Psychiatry
WI 13

.

J”

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6... 5.

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                    <text>7333-611

April 9th. 1973
Henry

P.0.

Brill,

Box

22,

M.D..

West Brentvood, H.Y.11717.
Deer Kenry,
Thank you far the envy of the eeeond report of the
Conmiseien. and the eppendieee to the first report. I
have given one copy to Stan, and he thanks you.

I have reed this second report, and once egein wish
to commend you and the Commission for approenhing the
issues with a Judieioueness and evenhendedneee that is
so neeeseary in this time when drug use remains a under
political iseue. I, too, have been frightened by the
rapid development of e "drug ebuee a industrial - univerlity
complex". Rate that I heve added "university" he your
caution, for no time in the twenty yearn that I have been
in research have I seen so many departmental chainmen
Jung on the bend vegan of drug abuse in order to support
empires threatened by e rednetion in training grants.
The emphesis on elechel as a drug of primary

eoncern

of €38

is well placed.

A

few years ego when Earl Ubell

celled
as he wee preparing his series
to Z". he was eurpriseé whee I innieted that
alcohol was a much greater threat end problee.than heroin.
Indeed. when he cheated, he was thin to present e more
baleneoé pieture at drug nee.
"Druge.

wv Have
A

we

Finelxy, I paid special uttention to the Genuinelon'e
attitude to the hermetic antagonists. Althougﬂtthe
reeauaendetione are not these which I heve voiced during
the peat m ywe. I eeneur with the Commission (m. 323-32M
‘

as the beat eonclueien based on the available evidence.

�Brill,

Henry

14.1}.

~2—

April 9th, 1973

Oneo again, I mt to than}: you and the Commission
far having presented ache:- and Judiciaua rocmendationn whieh
I hope the Ana-1cm people will accept.
My

but portend rem“.
Sincerely yours,

I

Max Fink, Md).
Professor at Psychiatry
RIP/1.1

�</text>
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                    <text>TBBB~608

April 93h, 1973
To:

Dr. K. Boson

FROM:

Dr.

SUBJECT:

'Msthsdone, Alcohal sad Drivins' by
Barnard Newmsn and Arnold Dihrbsrg

MIX

Fink

This retort attempts an intsrssting svslustion of the
sffsets of tbs interaction or asthsdons and nicohol in s
driving sinnlstion task. The design nulls for three groups:
nethndons msintensnce patients, voluntser male students,
and

policeasn.

This rsport is grossly insnmplste an a nutter of
important issuss.
1. me ststsnsnt is made regarding the campsrdbility
of tbs three grants. not only as to nae, but, more
importsntly. the significant issues or driving exterisnns.
The authors do not indinsts whether the subascts vars first
given an optortunity to pwsatins in order to hnvs maximum
success bsfbrs the test, at vhethsr the tests wars dons
with an unsqnnl initisl starting position, based on
differences in sxpsrisncs.

2. The data is not analysed as to whether the chain
scares (errors per subasct ~ stlst B, C, D and E) reflect
signifinsnt differences using stsndsrd ststisticsl mstheds.
In the absence of the dsts regarding ths range sud
variability of the scores, na Judgsnsnt of the msin
differences tan be made.
Conclusions

In the (bushes of statistical processing.

this dsts can not to interpsstsd. (Perhaps ths willingness
of tbs authors to asks conninsions based on incnnpiste
analysis reflects their inexperisncs.) Perhaps the
Commission could ssh that the data bs analysed by a

stntistiasl consultant.

Hrlij

Eat.

�M

f ﬂ! “9‘?

�</text>
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                    <text>7363-607

April 9th, 1973
Louis J. What, M.D.
Departnmnt of Psychiatry.
School at ﬂcdicina.
The Center for the Health.8ciences,
Lon Angalga, California 9002h.
Dear

Jolly,
I w0u16.be plea-ad to endorse your candidacy for

President or the

American

Psychiatrie Association.

I believe that the alection of A1 Freedman marked
a signitiaant change in thn ecurnc of the history of
the ABA. For the past daeadc I have antenna the ABA
attcriorate as tbs programs becwme too big, with
repetition of papers by the saw: people; the sections
were disbandod, so that man of common interact did not

have a nidua shout which to mact; the dues increased
exceasivaly with a heavy emphasis on building funds.
pension benefits, and ether monunaata for the central
office. I hurt also vutchnd the attcuyt by thc district
branches to aaaunn sans leadership, only to find that
thay are powurleas. and thnt provud a disapyointing
endeavor.

I

will unka heroic efforts to make tha
acciety
representative and to improvc its ability
to respond to the EﬂMUQrI- Perhaps, in your next letter,
you vuuld indictta such 183308 that you foal are important
to tha APA so that those vhn are inalinnd to sugport ynur
atndidncy will be ablo to docuannt their anyport with
stntcasntl shout the issues for the society.
know

my

that

more

Al

boat regards.
Exacercly yours.
Fink. M.D.
Professor of Psychiatry
Mb:

MF/id

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                    <text>.m

-—-r.'uLP,'wa-_,—

M

—nr

wwwpm

731:0856r

n

«

,-:.~

.11

April 10, 1973
Costss Stefanis,

M.D.

University of Athens School of Medicine

Athens, Greece
Deer Castes,

I had delayed paying the consultation requests as the
Association was over—extended in its advances, and the NIMH had
withheld payments until the accounts had been verified. I was
assured of payment today and on sending the enclosed as advances on
your requests.
We

have not yet heard from Washington.

The computer programs have been put on tape for you and
I have been told that there are documentation notes that will be
written for your staff. As soon so these are delivered, I will

send them on to you.

Dornbush and Volevks are continuing their analyses of the
and behavior date. Today, they assured me that these would
be complete by next week.
EEG

My

best regards.
Sincerely yours,
Mex

P.S.

Fink,

M.D.

still trying to get an export license. Last week I was
by the U.S. BNDD and told that my facility at Stony
Brook would have to be examined by New York State inspectors,
to assure the government that our facilities for the handling
of dsngerous drugs were 'secure'. We were examined on Thursday
and I hope that this means that a permit will soon be issued.

We

are

called

�</text>
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                    <text>Ex

7363-51!

April 10th, 1973
Crook,
Peychophermecology Reeeereh Braneh.

Mb. Thames

Rational Institute of ﬂeatel Eeelth,
5600

Fishers Lane.

Rockville, Mbrylena 20852.
Deer Hr. Crook.
Thank you for the infatuation regarding the progreee
of the grant epplicetion by Dr. Thomas Kenlon (MK 2&amp;323).
I have reed the revised program and believe it is
eeneietent with the recommendations or the eite visit team.
The present protocol does not require computer eqniynent
and in essentially en encasement of the visual eveluetion
or the EEG. This type 0: analysis is well within the
eulpetenee of the clinieel teen end ehould reqnire no
expenditures above those listed in the reviled budget.

Should

this program demonstrate merit. the cemputer
EEG

evelnetion of the
yeere henee.
With

studies eauld be anticipated

this in mind, I

ﬁbula be contributory.
Thank you

site visit.

do not

some

think another site visit

for the opyortunity to particiyete in this
sincerely yours.

me: Fink, M.D.
Profeesor 0! Psychiatry

mrlid

cc. to Dr. Doneld Klein

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                    <text>7:101

r.r-

[I'm-ran

T3SB~618

April 12th. 1913
Alan Bunny.

91.13.

,

Modicnl Consultant.
Clinic-.1 Drug Studies

Center for Studies of

Rational Institute
5600

timers um.

Rockdllc,

at

Section.

and Drug Abuse,
WileHaiti),
mm

Maryland 20852.
gag

ﬁlm-124;:

Dar Doctor Runny.
Enclosed

is the quarterly report

tin Joint {annuity-VA

due Max-ah 31w.

for

drug dependant» treatment facility.
We have been heartcned by the pram-en 1n the
acuity than
months and the hupm advice of visitors from
put few
in
local and national syncing. I trait this

hapm.

awry

Sincerely yours ,

ﬂak.
m
Profusor of

H.129.

159/13
Em: 0

thiutry

�STATE UNIVERSITY OF NEW YORK AT STONY BROOK

HEALTH SCIENCES CENTER
_

School of Medicine
Stony Brook, N. Y. 11790
Phone: 516-444-2413

Department of Psychiatry

w.

u*wu~—"

#7.,

,..,,.E...,.

Quart erlLRenor-t - 'DDTC

V-oam.

Department of Psychigizry,

§UNY

_ ,,____._

atiS’ico‘ny Brook»
_

and

Vétéfans AdminiStration Hospital, Northpdrt, N.Y.

January 1, 1973 to March 31, 1973

h Prepared

by

Max

Fink,,M.D.

_

-a-

V‘

- _..,. 7,-

�l.

Program
Admission of drug dependent patients to the inpatient unit

remains at 19 during the quarter; with an outpatient census increasing

fron.6 to

11

in

March.

Of

these patients, 19-21 have been sustained

on methadone and h on cyclazocine.
The

introduction of cyclazocine in

hesitation by the staff

and new

December was met by some

were inducted slowly.

patients

We

introduced heroin challenges in January, and defined blockade to
25 mg heroin at 2h hours in subjects at h.0 and h.5 mg cyclazocine.
Late in 1972

"

disorders of thought
opiate dependence.

we

that

became concerned

some

and mood which complicated

During the quarter,

these patients and found that

we

patients exhibited

the problem of

paid Special attention to

combined drug therapy was
necessary

in five inpatients receiving methadone,

who were

given antipsychotic (3)

and antidepressant (2) adjuvants.
The

rehabilitation

was improved with continued

efforts at

assisting the veteran_adjust to the problems of a declining industrial

activity in Suffolk
welfare programs.

County, and inadeouate local housing and social
We

introduced a model

home

living unit in which the

veterans are encouraged to solve the daily problems of self—maintenance
and home care.
From a

methadone

technical point of view,

tablets ("biscuits")

we

discontinued the use of

and introduced

liquid formulations of

methadone (and cyclazocine). Drugs are prepared by the pharmacy in

individual, patient-labelled, dated bottles.

�.2. Administration
The program was
Don

established in July, 1972, with Dr. Alexander

as the unit director. For personal reasons, he reduced his

attendance to two half sessions a week in September. Early in March,
Donald Swanson, M.B.B.Ch. was appointed as unit leader (see curriculum

vitae).
~w~rs¢~
—--—.~..

....w-———.—

‘

Institutional approval

Z-alpha—acetylmethadol

stabilized
we

we

was Obtained

(LAAM).

on methadone and who

plan to_transfer

DDTC

“”“M”

‘

"“'

'

,

them

have been

facility

LAAM

for the introductionmof_mw~‘~~

outpatients

who have
“a"-4..

been

-

attend the clinic three times
in lateﬂﬁpril.

'

'

M

a week,
'

””w”;

notified that the renovation contract of the

approved

3. Staffing of the

to

For

““““v-_*~”*

last

summer

willphe undertaken in

May.

DDTC

With the appointment of Dr. Swanson, the unit now

is served

by: Phisiciané’-”1T?WFTE;WNu£éé§“Z”6.7'FTE;“Nursing“Assiétaﬁ£"L~7.o
FTE;‘Recreational and Occupational Therapy - 5.3 FTE; Social Worker and Secretary

- 1. Consultant staffing is

h

half days each

week.

_"“”"‘”

l;

�E
E

-3—

b

For the period January 1

E

E

.
E

V

E -_

_

E

\

E

~

’

E

March 31, 1973:
9313;.

_

E

-

'

"lib.-

Admissions

SE

7

Detoxified

1

5

-—-

Inpatients

20

19

we

Outpatients

5

6

s“---

Methadone

Cyclazocine

.

\

1_9

22

“3

h

1

O

E

Drug

E

E

A

E

E

E

L"

.

,_.A,_

__

.-..........._._..

.

free

’1

�</text>
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                <text>1973 </text>
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              <elementText elementTextId="56208">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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              <elementText elementTextId="56213">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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              <elementText elementTextId="92945">
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                    <text>-.V«—~ﬁ.v~-WMW-‘w~"wwl—-‘Wﬂilr

:w‘

.7.“

,.,,,,_, -;.---v

"mu-«mmvw

~-.m 'I.'ﬁw§&lt;rrv ‘

un-

“WV-v.”.vn‘nww-mw-r-

7383—619

Amen

12th,

1973

Dr. Robert Bobimon,

A. II.

Remus,

Mass Drive,
Mahmud. Va. 23220.1507

Dm Dactor Rebinsoa.
we the curricula. vita at Dru. Robert
Swanson. pad :43 updated. unionism
for melt. I ‘hmﬁ than are main]...

Enclosed

a

Dana tad Donia

vita

Sincerely yours.
mrmmmwmv'mvwmm

F1“. “09.
m
Professor of E’mhiatry
.

ant/13

men.

�</text>
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              <elementText elementTextId="56198">
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                    <text>TSBBnSRl

April 13th, 1973
Mr. John R.

Coastline.

Karootie Investigator,
Suffolk County Health Dept.,
Hospital Affairs Division.

Route #113.

Riverlsigh Awa..

Riverhead, N.Y.

Dear Mr. Cossolino.

I am pleased to give you tho following summary of our
use of Schedule I drugs at the Health Sciences Cantor.

«pr-1

my”-

-‘—va.

rpm-rye:

F’s'"

m

war.

.

l. The principal study program is an evaluation of
narcotic antagonists and narcotic substitutes in the
treatment of opiate dependence. This study is in two parts
an experinentsl part at the university and a clinical part
at the Veterans Aﬂministration Ebspital in Horthport. This
study program is supported by a contract from the National
Institute of mental Health, HEM h2—72—llS (Antagonists to

—

Opiates).

In the olinicsl program at the V.A. Hospital in
Horthyort, we are treating veterans she have been using
opiates for two years or longer with oyolssooins. methadone,
lavomethadyl (l~alphs—acetylmsthsdol) and naltrexone. As
part of this program we also use heroin ehallenges.
During the next svo years we anticipate expanding the
substances to be tested to include diprenorphine
of
range
and 302605, as narcotio antagonists, and such other opiates
as may be of interest in order to define their duration of
action.

1n-

5W

“cw“mvm

arm“

V

Specifically, patients vith a two year history of opiate
use are examined and based on their psychological eharaoteristios.
recommended for maintenance or dooonditionins therayw. It
maintenance therapy. we follow the FDA guidelines for the
treatment with methadone. Approximately one half of the
subjects are maintained on lav dose methadone (upgrox. SO as)

�Mr. John R. 001501130

~2~

Agril 13th, 1973

and half an high dose (approx. 100 mg). During the ncxt
month a portion of tho patients who have been on methadone
ten months or longer will b: trtnsferrad to lawnmothndyl at 80
mg thren tinns a week. This, too. will fallow FDA

rusulationa.
Sam.

patients are inducted into deaonditioning thnrayy

in which they reeeive cynlnaoeine up to h mg a day (or
beginning July, naltruxona to 100 mg a day). At these
blockade

is

donagaa

measured by challenges with heroin or morphing.
usually 25 mg of auch.

In the experimnntal program ut thg university, um
are attampting to find the EEG and other phytiologie effects
of vurioun substances. unler this contract 9! are assessing
the EEG effects of naitroxona, morphing, diacetylnorphina.
etorphina, and extruetl o! cannabis. A yortion of this work
is supported hy MK 2&amp;020 "EEG in ﬂiman Psychopharmacology",'
a grant from the HIMH.
—

In this program suitable voluntecru are given
participating experiment: in the EEG labdratory and for
patina: of up to six hours have phyniolagieal recording
after adndnistration of one of the scheduled sﬁbstances.
substannos are dalivared, they are usually sent
office (at Stony Brook). Such supplies as may be
naceassry at the Vbterans Administrutian Hbspital are
trannshippea to the V.A. and maintainod in a safe similar to
that which we have at the university. (Pbr methadonn and
other aubstanaea usually available to thn V.A., we obtain
our supyliaa tram the yharmney which maintains the basic
anywlics and rcoorda,and delivers to us, in individual
bottlas, drugs for individual patient: fur specitiad days).

to

Khan

my

2. Fur a number or years at have been studying tbs
smoking cannabis, hanhinh. ind various derivatives.
such as TEC~delta~9, Tﬂc~deltn~8. cunnubiéiol and canndbinol
on physiological maasures such an EEG, heart rata,
respiratory rate, pupil 3130, ate. This wart was done in
New York under RIMS grants, &amp;na a eontract HEM h2—70~98.
This contract included a study of chronic hashish usara in
Greece. where um have 1159 examined the ﬁkysiological
attceta of that: antitancen in tents inhalation experiments.
This part of thn wart in Grace: is continuing and.v¢ have
reqnnstod funds to cantinue tho v.3. portion at tha
Uhiveraity.

effects of

�‘Mr.

John R. Ccaaclino

April 13th, 1973

~3~

In the laboratory vcrk, cuitcblc volunteer: inhale
these substances in thc KEG laboratory and remain under
supcrvinicn far periods up to eight hcurn. Physiological
rnccrdingc are than analysed.
3. Am the present tins cm are negotiating a contract
with thc V.A. for the ccmpcriacn of lunlphc~ccetylmcthadol
and high and low dose methadonc in the maintenance of
patients. This atuay, if it is fundcd, will he dcnc at the
V.A. in ﬁcrthport with cutpctiant units at still to be
dcsignated‘tizci‘in thc County, one or which will he at thc
\Hcalth Scicncea Center.

are not limited in our studies ,6 Schedule I
substances. but also access substances in Schedules II, III,
IV, and v. Fbr all these atudies, for such substances as
heroin, marihunna, THC, ccc.. supplies are obtained tram the
NINE. we have in the past, and plan in the future, to
obtain supplies of cannabis tram this source and transahip
We

these to the university of Athens under our contract
Bhiymcnt is to Professor Costa: Stcfanin.
at tbs University of Athens (Th, Vasilliasis Sophia: Ave.,

H83 h2—70a98.

Athens. Greece).

Occusianally

we

deal with substances which are sent

to us by laboratories in Europe or the U.S. In the past,
this has been true for hachish, etcrphine. and diprencrphine.
As our studies continue, we anticipate immorting such othcr
substances as may be necessary fcr our studies, and which
may be similar to the one: already atudicd.
5.7-

-(n'

a»:

a"...

This stctcmcnt is submitted in support of our
application for a licence to engage in research with
controlled substances. I trust this infbrmation is useful.
Thank ycu

fbr your acsistance.
Sincerely yours,

max

rink.

M.D.

Professor of Psychiatry
MF/ij

«1—sz

.

’

�</text>
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                  <elementText elementTextId="106681">
                    <text>.,, ...v

V

5.

V

.

,

,,

.

..,..r., _w.,_._. v,.. ,7“. 7“...“

m.

,.

.

u

-—-,

"-VV.'-'

—_,

,__.,.,_

-...—n—.,...,.._v«-rw.7-

A.

73SB:09lSc

April 1h, 1973
Mr. Herman Heisman

Sr. Clinical Associate

Hoffmenn~Ls Roche, Inc.

Nutley,

ﬂew

Jersey

Dear Bank.

Following our discussions, I have revised the protocol
the ongoing study or the EEG profile of bromszepem (9 mg),
diszepem (10 mg) and placebo, with blood samples drawn for
fOr

assay of these substances and metabolites befbre and 30, 60
and 120 minutes after drug ingestion. A copy is enclosed for your
review and

files.

-

study began on Thursdny. In three sessions that we
encountered no difficulties beyond the discomfort of the
ran,
subjects at experiencing four withdrawals of blood. Should this
become a problem, we may have to increase the 'bonus' paid at
the end of each study.
The

we

my

best regards.
Sincerely yours,

Mex

Fink,

M.D.

�</text>
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                    <text>«WV.

.,.

“Var—.mwx.

—.v

'V‘Ir”

~-~

-

._...7.—.w~,..—.,‘.w~wow—wuwmy‘n»

.

v

-

.

-,.

--

,

‘—

‘-

73B:0900r

April 15, 1973
Dr. H. van Riezen
Scientific Development Group
N.V. Orgenon

088, Holland
Dear Hank,
IND

Dr.

the enclosed copies indicate, we have filed the
and the extension of the ﬂI-63 for Dr. Kaetin.
Kastin is free to begin the project; I have to wait at
for

As

GB—9h

least until

May

5.

The 01-63 experiments have continued until we have now
given 7 (x13.5 mg) ampules in 9cc in 2 minutes. Even at these
dosages, there is little to be seen in the visual EEG. We are
reviewing the computer outputs and the symptom reports. In the

are some suggestions of effects; and if these
are substantial and matched by the EEG, we will do a direct
comparison with placebo.

letter, there

ﬂ,“

v“...

,
_.,_._..,....._.,,

I have spoken to Dr. Esemen, who received some supplies
from you and will do the studies later this month. I have not
spoken to Joyce or Iver.

V'rw—

wuﬂwr

family.

My

best regards to all you! associates,

and to your

Sincerely yours,
Max

P.S.

The work
my

at Stony

Brook

Fink,

M.D.

is going very well. I should close

laboratories in the city at the

end

of June. Also,

found a small home on the water near Stony Brook, and
in the midst of the negotiations now.

we
we

have

are

�</text>
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                    <text>WW

731-623

April 16. 1973

W,
m,
5600 Fishers Lane,
aockville.

Maryland 20852.

Gentlemen.
Attachud in u negatiatad tgroamant dqted Mitch 21, 1973
ostdblishing a provisional overhead rate of 2&amp;5 for all
programs of this Association affective 7/1/72.

In prior contract raiuburaamnntn during this parted.va
have raqnnuted overhead reimbursement at 205. Total Garnet
coats ware $7,078.08. we have bean reiﬁburaed 1n the umaunt
of $1,»15.61. A calenlation at an; yum; indirect cast a!
$1,698.7h. The difference of $263.13 in a reimbursement
reqnnated in cur request autad April 16, 1973, to which this

letter is

uﬁtuched.

This change in ovurhaad rate will not interfere with the
porfbrmange of tho conﬁract Gr subcontract. It in our
undnrstanding that thia gantract may‘be extended for an
additional 6 montha. and under that extension we will request
nupplamentary funds to gravid: for the increase in overhead.
should such request fur ndditional fund: prove necessary.

sincerely yuurs.

i-nmxawaw

Mt: Fink, M.D.

Exscutive Director

XIII:
Enc.

�Avril 16. 1973
Contract

Ruforonce

Previauuly

Expenditure

Cialnnd

annulttivo

“N

11,537.00

This Period

?ﬁimﬂnuiiv

Tbtnl

Contraet

III

Dtipcnds

c—1

Supplies. Communications

C—E

Oak

III

Bul

3-3

B~5

B~6

Equipmsnt

1.h1h.73
13,359.50
h,721.00

Salaries

58.1‘31000

and Camputer

W
c~3

east:

11,537.00

lruvol

Lib. Analysis
Vbluntcar Faun
EEG

2,916.20
~m

h.soo.oo

12,83h.oo

1,690.00

Recording

h.330.93

13.359.50

h,721.oo

~‘h

58,h31.oo

a.“

12,83h.oo

on“

1‘

$2,916.20

Overboad (2h!)

622382

Additional overhead for period 7/1/72
2/23/73
Total

»

3,616.09
283.;g
$3,899.22

Eh: unaornigned certifies that tho cost at the acrvicos roiﬂburaablo
to thp Contractor and the Imount of the to: onrnod by the Contractor to
the ante of this certificate are not 13:: thin the total payments received

:3 claiaod by the Contrnctor (including tbs pcyment claimed herewith), and
tbs Contractor. to tbs hast of his kaoviedgc and belief, his eonpliod with
tho eanditions of the contract fully.
Ht further certify that tbs amount: inwaicod bargin do not exuaad
thy lovnr of the contrtet prica. or maximum levels esttblishnd in
accordance with Executive Order llﬁho or January 26, 19ﬂ!.

Intornaiional Association for
Psychiatric Research. Inc.

Fink. M.D.
Executive Director

By Mb:

9500.00

1,690.00

�W

January 25. 1973
6:01
The sixth annual wanting at the Boarﬂ of Directors
of the Association was held at 6 p.m. on Thursday evening. January
25, 1973 at the home of Mr. aha Hrs. Henry Faiwel, 7 W. 81 at. in
ﬂaw York City. All members of the Beard (unasrs. Canter, Fatwal,
Fink. Green. Israel, ?oge1) and a cannultant, Dnnsld M. Shapiro. 9.56.,
wore present.
6:02
The minutes
upgroved as airculated.
'

at the

mecting

at

Decembar 20. 1971 ware

The year's activitias ware reviewad by Dr. Fink.
6:03.10
noted that the studies or convulsive therayy were campleted. sun
had confirmnd that changing electrode location raduned comglicationa
of unwary less an&amp; yet sustainad tharapeaﬁic efficacy; and that
mmltigle seizures in ona sitting were safe, but of occasional
therapeutic advantage over single seitures (mﬁ 15561~03).
He

6:03.11

The conference on.Pchhnb£oZogy af‘Cbnvquivs Therapy
£0162) was held at the Dorado Beach Betal in Fumrto Rice in
April. Dr. Graen represented the Association ané reported on the
uaadaaic effort which wag austained for 3 ﬂaya despite the attraction:
or the beach and sunshine. The proceedings &amp;re new ccmplete and.w111
(RH

be published by v.3. Hinston ana sons in Eeptewber. 1973.

As one consquence-ot the mgating, song collaborativa
studies were stimulated. walier B. Easman, Ph.n3, M.D., ?ro£essor or
Faychology at Quesns College has submitted an application to KIMH for

6203.12

a study Ekurcohamical Changes
zuypozthog
RE 2 1 5

in Eiaatroaanuulaive shock

.

Qur sacond fauna of interest is the atudy or chronie
6:03.2
bathtub users in Athcns, Greece (stuh2.?o~98). Laat year we found
the population of users avgilable {hr stuﬁy ta have amoked hashiah for
an average or ah tours, and to aha? few madical handicaps beyond
cmphysama ana poor dantitian. We noted that tha subjects were hatwy
smokers of tabaoco and tha$ this preventaa any conclusion eoneerning
hashiih use alone. Because the man showed great tolerance tn canndbis
wt proposed this-year to test their response to v.5. mariauana. the
pure active aomponant (TﬁﬂwAn9). and tn high doses of hashish. Thane
studies in 20 subjects have been cangleted and the data is now in

analysis.

�“2*

6:03.30

the program
transferred

On

A

new

area of Aoaoeiation support

this year

in

was

and Ewan Payohophamoowgy (mahozo) , which wen
from the Kev York Modieel College to the Association
October 1, 1972.

6:03.31

EEG

feeilities at a

In the negotiations in the spring, renovation of

new site and transfer costs were found to require
about $22,000. we were assured of $16,500 to $18,000 by the notional
Institute of Mental Health, and requeoted the Association allow
expenditures of ita'funds up to $6,000 for these purposes. Dre Green
enquired whether the State university at Stony Brook would not
provide for these costs. While the university mey have dooe'eo,
it would not have been feasible before l9?3~7h, and would have
required tranafor of the NINE support and equipment to the university.
‘

03 32

expedite continuation or the program and to
of these studies, the Board approved
the allowance (to $6, 000) provided by the Executive Committee in
6:

To

J“13* 1972 o
6:03 us

The Association made two grants—in—aid

maintain e direct

AIME support

in

1971—72:

$1,717 to the Universitv of the West Indies, and $1,000 to the
York Mbdical College.

New

:u The west Indies grant provided interim support for
6:03whl
personnel in a study of ohronie ganja users. We had anticipated
HIKE support for these studies. Approval was given by KIMH but on
final review was withheld by the Department of State, which noted
that a prior contractor in Jamaica hed failed to abide by the
regulations regarding publication w their results were published by
the Minister of Health without prior 8.3. approval.

6:03.h2
The New York modioal College grant was in support
of legal assistance required by the Department of Psvchiatry in
negotiations with the City for continued roeearoh and teaching at
Metropolitan Hospital.
An extensive audit of the Aeoociotion'o records for
6:03.5
the period Juno 1, 1968 to May 31 197 by the comptroller, HEW
audit ogonoy, resulted in a lengthvreport (July 6,1972) (Audit
Control 300h6~02). most of the oriticism was focueoed on a look of
controls of expenditures, purchasing, and time records, these
being monitored by the Executive Director. many of the suggestions
for inoreased control were adopted, and on August 2h, we responded,
noting the changes which we had adopted. 0n Hoveeber 30,1972 we

wore advised that our response was satisfactory es to the management
eepeots; and on January 17, we were assured that the costs incurred.

were deceptod, without penalty.

�«r.

.~

._.

-—;,.v

,1,

&lt;4

_—v,.

“-rv»

m7

”sumac-m-nruwwn;

v-r

4“,.“

m'lm’"

~3—

6:03.60

With the transfur of tho grant EEG and Human
Pbyohophanmaoology, equipmont and programs with a replaonmont

valun of $130,000 were accepted by the Association. In discussing
the inaurdbility of the equipment, the question or title van raised,
and tho Executivn Dirootor was aakoa to nttompt n definition of the
present title, and legionl source or funds for payment or insurance
proniumn._ In the intorim, Mr. Cantor assured the Board that the
equipment was insured_for replnnqmnnt in case of major damage.

6:03;6l

by source.

site,

‘

6:03;?
with thanks.
'

6:0h

roqueuted an no~to~dnto inventory of nquipmnnt,
and estimated rnplnnemnnt coat._
.'

The Board

VThe

Board accepted
'

the Executive Director's rcport.
.

.

The 1971~72 annual finnnoial report, submitted by
Zimmerman was roviawod; and aceepted.

Panoth, Hobor and

6:05
The 1972n73 reonoat budget submitted by the Executive
Director was reviewed ana approvea.
6:06.1
The Board went into executifo session, as the Commitﬁoo
on Exporimnntnxion in Man, chaired by Dr. Martin Green, with Professor
D. M. Shapiro as special consultant.
The Committee revieweé the assurance of the study of hashish

users in Greece; noted that no additional studies of BOT ware donc
since July 1971; and reviewed the protocol and consent form for
studies of new drugs in the program, EEG and Human Phyohopharmaaalagy.
The Committee recommendod chanson in the consent form, and with the
assurance that those changes would ho acoeptod, approve&amp; this study

protocol.

6:06g2
The Board re~convened and accepted tho
Committee an Emparémnntation in Man.
6:07”

The Board re—elocted

its

report of the

newborn; elected Donald

Shaniro, D.8¢. as a new wombat; ﬁnd remelocted Max Fink, M.D. at
Executive Director for 1972u73. The Board elected T. J. Israel,
as President; and Mbrtin A. green, M.D. no secretarymtreannrer.
?anoth, Haber ana Zimmerman were named auditors for 1972—1973.

M.

Jr.

6:08
The Board gratefully acknowledged the
of Mr, and Mrs. Foiwnl for the annual wanting. In the hospitality
ensuing
disoussion, reprcsontation by woman on the Board was raised an a question,
and the Prcsidont ogreed to oonsidor snob nominations to the Board at
the next meeting‘
6:09

The meeting was adjourned

at 9.30 p.m.

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                    <text>7383~62h

April 16, 1973
Dr. P. Gilbert MbMEhon,
Read, Therayeutlc Section.
Departmcnﬁ of Medicine,
Tulane University School of Modtetno.
lhBO Tulana Ave..
new Orleans, La. 70112.

a

"warm-w?!"

nn—uw

man

"'meth

1:21am

I

.2

g

Dear Doctor Mhﬂahon,

is a statement from the Harriett Mbtel. It
underntandlng that this would be paid by the master
account.
Enclosed

was my

,

If that is incorrect, please send it back to
will arrango far payment.

me

and I

for your kind invitation and for the
ylctures which I received this morning.
Thank you again

Sincerely yours,

Fink,
Professor
max

Mylié
Baa.

M.D.

at Psychiatry

�</text>
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                  <elementText elementTextId="106677">
                    <text>7.,4.‘

,,

“MM...” .._.,,......

W.

NV

.

.

7388~626

H

‘

»...,,..-w-w..~u-~T.n-‘Hmy

.»

,

- ~- .

”an

‘

«.wr

r

""

»-

~-./

Agril 16, 1973
mo:

Leonard E. Mbiselss, M.D.

max:

Max

SUBJECT:

Control of drugs on campus from.the University Countel

Fink.

116.1).

namornndum

2/26/73

In response to this llnnrandum. I have dincuased the new
regulation. with representatives of thn Narcotic Control Bureau
of the Bogartnent of Health of Haw York.
Present regulations are being interpreted that individuals
individual labaratories are to be licenssd, rather than
institutions. excepting hospital pharmacies.
and

In tddition to conplying with New York State rnguletione,
applications must also be made to the Bureau of Earcotics and
Dansaraua Drugs. The pwoper sequence for a scientist is to
take application and obtain approval tram the ﬂaw York State
Dopartmcnt of Health. and based on this approval, apply to the
Bureau of Narcotics and Dangerous Drugs. (Depending on the
project, separate additianal applications are ordinarily made
to HIKE, FDA and other agencies which actually supply controlled
substances).
Because of the couple: nature of the regulations, it would
be advisable for the Health Scicncas Center to appoint an officer

with tho rnsyoncihility to: .‘ “maintain a file of pertinent
resulstiona; (a) advise mamhefs of the Health Sciences Center
professional staff in matters of complianca; (3} mnintuin records
of approved application: within the Health Sciences Center; and
(b) coordinate tho use of facilities specifically nacesaary fur
the control of thase subatanccs. ﬁnch an officer should natify
periodically (unannlly?) the ﬁles ?reaident for Health Sciences
of thn status of applications and tho use of contrailed aubutnnaos
in tho institution.

or a single application from a single office
for research in controlloa aubutances is not foasible at this time.
The conuept

HF/id

'-"'

�</text>
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                    <text>731-622

April 16th, 1973

qu.J.mn&amp;nnq
Cantrtcting Otricer,

hr

mu

char-was

Chief, Centractl Minagcmnnm Bastion.
Grant: anﬂ Contrnnta Manngannat Branch,
Hational Institu$e of thtal Ecalth,
5600 Fishers Lane,
Rockrille. Maryland 26852.

VW4"W¢"L'1‘/“"I"

Dear Mr. Grndvell,
:w-‘m'quwwvr

HQ have been notified by taluphano by Mr. Jack
Johanna of your office thax aur reqnsnt far an cxtansion
at HEM h2~70~98 for six manths bawbnd June 25, 1973 has
been approved by the pragrnm review toam, and that it is
your Intent to fund this request. Mr. Johnson indicated
thut a formal artension will reqnire some time to:
processing.‘but assured us that we should proaoed on the
assumption that our raqnast will be ”substantially" approved
there being same itaau which arc subjact to nagotiation.

-

the assumption that this assurance in substantially
are notifying the subcontractor. Professor C.
steflnis of thc Untvernity of Athuns to proaeed with the
special studies (nusaasnant of withdruvll otteats) outlined
in that request.
0n

correct,
A

vmv

um

If this

asauranne

of tha coumnniention of
natify ma promptly.

is in Jeoparay. or our interpratation
is in error, pleas:

Mr. Johnson

It is also my understanding that the praparationn for
the unsatiationa for the axtennion will require 3 to 5 vuoks.
I trust thane conelnsions nrc aorreet.
sincerely yours,
mmmwcwnnnmm

Max Fink, M.D.
Professor of Psychiatry

MF/iJ

ea. Costa: stefanis, K.D.

�</text>
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                    <text>war-

“pm—M.

—-—

n

.7,

i

,. w. nwnwr &gt;TWV' ‘

-r.v-

W.

-,.—v—.r.n.

v

-unw—
-~w-v:wxmmn€v-VW&gt;—w—

mi

7"

a w 'v/ ‘n—y-uw

-:-w:.:v-.»vuwmw,r—V,VMW ,.

,W

738:092mf

April 16, 1973
United of Omaha
33rd &amp; Farnham
Omaha, Nebraska

Ref:

.

Gentlemen:

I

am

GL6

1387

Cert 01151

writing with regard to the policy listed above,

on the life of maximilign Fink. I should like to verify the
owner and beneficiary of this policy, and ask also that you send
a form apprppriate fbr change, should such be necessary. (It

is

wish that the policy be owned by my vita, Martha 0. Pink;
that she,!and not my estate, be the beneficiary as well.)

my

and

Thank you.

Sincerely yours.
Max

Fink,

M.D.

�</text>
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                    <text>TBSB:09SSC

April 18, 1973
Turan Itil, M.D.
shoo Arsenal Street
St. Louis, Missouri
Dear Turen,

as

Enclosed

we

discussed.

is a revised protocol of the

The only item

ORF

8063 study

omitted is the collection of blood samples.

They (at Ortho) are willing to analyse samples for car 8063
and for the metabolite. In our preliminary studies, the metabolite
has e very long persistence, and it is possible that it is this
agent that in the active agent. It would be most useful if the
staff could collect and freeze 10 cc blood samples at each
visit. Near the end of the study we could attempt to ship these

under dry ice and if the analyses are done, it will provide
an independent measure of whether the drug wee taken, and
a reference for the therapeutic effects.

records.

It

could also be useful in conjunction with the

I would, therefore, ask

your knowledge of the
My

setting

EEG

you to review the protocol with
and add the necessary instructions.

best regards.
Sincerely yours,
,2?

Max

Fink,

24.9.

�</text>
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..

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731: 09hI
-.L__—._

April 18, 1973
M.D.
Itil,
Missouri Institute

Turan

shoe Arsenal Street
St. Louis, Missouri

_—.h==&amp;:$h

of Psychiatry
63139

._.;‘._i.h“\l;-_e_._‘_‘___..___ge

Dear Turan,
The Association would be pleased to accept grants-in-aid
on behalf of your studies, and will process the requests for
expenditures according to the instruction: accompanying the
awards. In our negotiations on behalf of others, with for
example, the National Institute of Mental Health. we have received
an overhead allowance of 2&amp;5. In other instances, we have
negotiated a flat figure of lesser amounts, and we would be
able to establish an overhead rate for each study.

enclosing sample copies or the forms used by the
Association in its bookkeeping operations.

I

am

to using the conditions of the
director in approving the
executive
award as a guideline to the
Board
may. at its discretion and
expenditure requests; but, the
your request, consider modifications consistent with the intent of
the award.
We

have been accustomed

I trust these notes are helpful,

earnest cooperation.

and

I can assure

Sincerely yours,
6,
‘

Max

II

V;

Fink,

M.D.

Executive Director

you

of our

'

\

~&lt;.i_.a..-.._~

�</text>
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                    <text>'‘g'

ruwvmusuv

K"

731-632

April 19. 1973
James mama. Pam...
Professor at Pmkxmiolm,
University of California,

Irvine, California.

Dear Jim.
0:: first. Mm'of the nun-y. I gent 115 on
to the publish”. In ”wt-caning 1% today. I Milled
in a. fur unassisted emits” in style, reﬂecting
and. an: willingthe format of the othcr mo
Archives
send
on
these
to
the
simltsmous
to
for
mu
.

Win,

publicatian. Please consider than suggastiona, and
let me knew if they are acceptabla.
)5 thanks.

81:3:me your: ,
1h! Pink,
luv/1.1

he.

an. T.

A.

V1111!“

H.134.

�</text>
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                    <text>731~631

April 19. 1973
Beynour Kety, M;D.,

Professor of Psychiatry.
Ehrverd Mhdieal ﬁchool,

hissechnsetts General Hosyitel,
Fruit Street.

Boston, Ma”. 02121:.

5

Since reading the summary of the ECT conference. I have
had time to reflect on the eenelusions. I as writing to reise
some questions. not about the summery presentation. but the
tonelusion of the role of cholinergic mechanisms. As I

understand the relevant paragraphs (page: 5a6), the date for
the role fbr seetyloholine ere unimgressive. and do not meet
the ariterie fer relevance, set teeth in your earlier
peregrephs. The persgrsph focuses on the report by Karcxsnr.

years ago I reviewed the data relevant for a
(1) I fbund the ehenges in cholinergie
measures ta have s time tour-e similar to the heheviorel
(end electrogrsphie) effects. (2) Specificity was herd to
demonstrate, but eerehrel trenme and neurological illnesses
did not exhibit the seas eholinergie effeets of seizures.
(3) Using sntilhelinergie drugs, I was dble to reverse the
electrogrsphia and behavioral effects of EﬂT. The date are
not avervhehsing. but teken as a whole, the ante impressed
me that eholinergie mechanisms were relevant to the ECT process.
Some

ahelinergie hypothesis.

objection to the hypothesis is thst entheholinergic
drugs. like Ditrqn, have elinieal entidepreesant activity;
end the suggestion I msde in 1958 that iuiprnnine has
entieholinergic activity also refleets on e eholinergic
hypothesis.
An

In your summary in Doredo Beech. you viewed scetylcholine
ss relevent to the seizure threshold and as reflecting the
widespread activation of neurGBS“, without specificity. I
thought then that your argument use cogent. Particularly,
that seetyleholins. es en ubiquitous trunsmitter, may reflect
the inpeet of the massive discharges oceseioned by the eeixure~
inducing agent.

But

this hytotheeis. of nonuepecifieity, is

�Seymour Katy,
on no more

~2-

April 19, 1973

substantial footing than the suggestions of

epeoiticity. Indeed, the more prudent course may be not to
enticipete which neurohnaor is the more important, but to
reflect on all.
for the role of biogenie amines

who evidence

changes in protein synthenie in

part, this

may

and

is well documented. In
reflect the availnbility of adequate and
BOT

toehnioelly simple

methods of nnnlysie. In ooneidering the
ohelinergio hypothesis, vn are faced by the technical problems
and ineoouracy or hionsaay methods. Such difficulty must have

contributed to the peueity or studies in ECT. I knoV'thnt
this technical difficulty has deverely impeded my studies,
for when we did biouetdye for AOh, we found them too unrelidble.
But. from this vantage point, descriptions of improved methods
for assaying acetylcholine (gas chromatography - mesa
spectrometry en deeoribed by Jenden at the ACE? in 1972. is
an exonple) encourage me that more adequate tests of oholinorgie
hypotheses in

ECT

are feasible.

will be read and en your opinion is highly
valued. your conclusions may influence further studies of
ECT. Alex did not present the oholinergio date well; and I
Your summary

cannot do

better.

Presuming on our companionship, I am enclosing a copy
1966 summary. The data are meager, but may be nutricient
to quicken your interest in presenting the cholinergio date
with slightly more optimism. Should you wish to do so, fine;
thould you‘wish to ignore this point, I will not be offended.

or

my

:
"T

5-12-17va

3.9.

you

The volume in almost complete, and once again I thank
and encouragement.

for your advice

my

":7'1(‘l

':3

best regards,
Sincerely yours,

nmwv-w—

“If
-r=:

Mex

12m

MF/id
Ene.

Fink,

M.D.

�</text>
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                    <text>TEE-633

April 19. 1973
School of Pharmacy,

The Hebrew

University of Jerusalem,

Jerusalem, Israel.

new Raphael.

um

m

written. and
use since
It has been
have not had my word. form]. or intern-.1, ”strung
your application to the Rational Institute of Mental

I

Health for the study "ﬂmotte Antagonists in Anisotropic
I an writing because I bl" received. inform}.
word that the
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such
contract.
work; and is, this week,
in
doing
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sending out. form]. rogue“: for bids from individuals and
agencies who have tha background and mutant to do web
a Job.

Mm". m
and.

that

mm

If. yet: have not. heard affirmatively from KIWI.

are

you

intuntod in this mom, I would
mu
write dircctly to Dr. William Bunny at

oxphinina your interest cad «king for
(1 dc not have

Jttfea‘

I

would

am. or I

would

also and the

(mm.

and

same

a.

Dr.

14:. White Home, wuahxngton,

In each letter you
have
heard of this
you
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Jam H.

9.0.).

my,

m

m, m.

copy or the

it to you).

letter to

suggest

11' you V1.11, 1341mm,
from no 62: Alfred.

but

that

regards .

ﬂuently yours.
mu:

rink. um.

Professor

per/1.1

at Psychiatry

�</text>
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                    <text>Av

rm"

‘&lt;

"P

—‘

rrt"‘W-‘?7"‘

memmMn-ywx-

7383.629

April 19. 1973
Dr. William Biler.
Biomndioal Engineering.
Dovnstate Medical Center,
h50 Clarkson Ave.,
Brooklyn, B.Y.
Dear Doctor

ﬁller,

?or tony yours I have had a laboratory for EEG
IBM 1800 comyuter as a proeesoor.
This winter I moved the laboratory to this University,
leaving-bohind my close associate, Donald Shapiro, 0.3:.
In discussing a replooumont for him. he suggested that
I should write to you and ask whether you had some
candidntoa graduating from your progrtm who might be
interasted in computer applications to physiologioal

analysis, using an

signals, particularly EEG and EKG. If you have some
at the M.S. lcvol that you would recommond
to as. I would appreciate roeoiving copies of their
curricula vitae.
graduaﬁon

Sincerely yours,

m

Fink. ”on.
Proton-or of Paychiatry
MF/id

�</text>
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                <text>Correspondence to: Mechoulam, Raphael</text>
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              <elementText elementTextId="56062">
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="106670">
                    <text>Sent

I

to: Richard

Alfred Freedman, M.D.
'Martin A. Green, M.D.
‘Martin M. Katz, Ph.D.

‘

‘

A‘V’

Prof. Luigi Velzelli

Abrams, M.D.

Rhea Dornbush, Ph.D.

1

:

‘-

Geller,

M.D.
Irwin Kbpin, M.D.
Jan Volavka, M.D.
Giacomo d'Elia, M.D.

Anne

,

Mayra Williams, Ph.D.

Steven Zornetzer, Ph.D.

Williams,

M.D.
Steven Secunda, M.D.
Seymour Kety, M.D. and James McGaugh, Ph.D.

Thomas

731-633

Agril 19, 1973

walter Essman, Ph.D.
Arth‘ur Cherkin, PhQDO
Dr. Adrian Dunn
Alex ICE-ream, NJ).
Joseph Mendele, Md).
Gordon Pryor, Ph.D.

Jan-Otto Ottoson,

M.D;
Joseph Schildkreut, M.D.
Iver F. Smell, M.D,
Joyce D. Small, M.D.

',

Deer

the reports of the
I eu.pleneed to tell you thatECT
are in the hands
conference an 2g; zgxghgbgglggz of
&amp;
of the publisher, V. E. Winston Sons, who plan to have
in Septenbee. The volume.v111 be
will be
published at a reasonable price ($l2*$lh) eand
Sons.
distributed and advertised by John Wiley

the

volume eypeer

and
like to have an upmto~dete title
address
eddrese list for the yertieipente. If the card andon
the
this letter is correct. please initial
academic
titles. If
adding
proper
your
return, after
indicate.
we weuld

there are any ehangen. please
we will tend gelley proof: with the usual request:
for prompt return.
June or July, and know e
If you plea to be away inI would
epyreeieto receiving
temperery fbrverding address,

it.

the

We

are grateful for your participation, and hope

volume

will

meet your

expectations.

sineerely yours.

Pink, Md).
m
James McGeugh, Ph.D.
Eeymour Keey. K.D.

Editors

mr/id
Ene.

�</text>
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Amril 19th, 1973
Dr. Jchn R. ﬂushes,

Canaultina Editor,

EEG
aWTn-K‘Wﬂw&gt;'

qurnnl,

Book Ravicva,

Northwestern university,

303 3. Chicago Ava.,
Chictgo, Illinois 63611.

4_.‘rl'vl~'l

A;
w.

.
,rv

,r-w

v
—«

v'wp‘I-ﬂlnmsmr

=-—u:—.v.v,

W 30m.
I have received the voluna “International Review of
Reurubiology". and look tbrvurd to reviewing 1t fur the
EEG Jburnul. I have a tow chore: to do over the noxt few
vuckn, but should got to it during late Mhy, and helluva
I can must your July daadline.

Thai-v.11"

thy

err-"a

v-wo-

thank: for thinking of no.
my

4‘5'

den:

best regards,
Sincerely yours.

woman-UV»:

Fink. M.D.
Professor of Psychiatry
Mb:

“/""‘.‘.‘

gnmlr

.5
up.

warm}

A

«2—

v.:W’u-'&gt;¥"‘:--I..,-r~rr.~

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"mm-m,

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v
V

'1'.“

v-

mmc'rm‘mr

'

7333-5330

April 19. 1973
Dr. Richard Abram: .

1h2 Columbia Heights.

Brooklyn,

ELY.

Dou- 10101:,

I have reread your contribution to the EST
volume. In the: context: of tho two reports by Banter,
copies of which arc ”cloud, it might ken thc
value up to date you would add a. postscript,

footnote. or s
the contaxt of
of course, add
place. If you

would be most

it

paragraph, placing their work within
your review of multiplo ECT. We will,
the (citations at the apt-mint:
could do so within the next. week. I

grateful.

w but regard...
Sincerely yours ,.

m: ﬂak.

14.9.

Profane:- ot Psychutry
MI 13
Enos .

�</text>
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                    <text>73828-628

April 19. 1973
Mr. &amp; Mr:. Henry retool,
7 What 8lst Stroot,

New

York

City,

E.Y.

Dear Hurt: and Hoary,
An I thumbod through my’nail the other day, 1nd
sonnnod o host of Journals and Junk. I saw the uncle-ed

covor, and without looking at tho credits
immodlotcly

I

it

do not

was can

of your friends;,

knew

think the roproduotlon does his

work

Justice. but I must admit that this kind of op—ort
in interesting. Perhaps «won more so is the fact that
I can recollect of no other modern pointing reproduced

on the cover of thin Journal for usny. many months.
They usually use a olaasiaol. representational type

art.

of

Martha must have told you that vo are Joining
you in Iuyporting a second house. w» have found a

cottage overlooking the voter in strong’s Nook (Betauket).
is tvolvo minutes from.my office at the Univorolty.
A: MLrthu says, it in possible to stood in the middle of
the living room with a dust cloth, turn 360°. ond have
completed the cleaning.

Th1:

I trust the family are wall.
my

boat regards.
Sincerely youro.

Mn: Fink. M.D.
Professor of Psychiatry

MP/id
Eno.

�</text>
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-\-~

vi

:
mu

.n'.

.-—,~m

731-63h1

:
v,

---v:

.
_.

April 23, 1973

xrarwm:

Mr. Clsronos Hsrdy,

Cost Advisory Branch,
16A55.

Psrklsvn Building,
5500 Fishers Lone,
Rookvills. Msrylsnd 20852.
Dear Mr. Hardy.

In response to our discussion on Fridsy, I so
pleased to enclose two itsms thst you requested - the
annual financial report of tho Association dated June
30th. 1972, and a copy of the Hutch Blot payroll of the
Association.
The

payroll

supplenontsry

ls

it.

for the Association. A
for the quarter from the subcontract

I would be glad to send you a copy if you
For your information, the titles and salary

dun us and

rsqnsat

list

list is

ranges are listed:

Fink, Exocutivo Director
Thion, administrative secretary
Snapper, progrsumer

n,

n;

,

.

Poinior, rosoaroh assistant

_

V

assistant
Kurss, research assistant

4

__

i.
.

my.”

”ma-.2

An,

.o-

..

.;
’41-"

“7503‘

V

i.

Those

~

-

~

- $6,800—$9.600
- $6,800~$9,600
EEG
~ $7.2oo.$1o coo
Garcia,
technologist
workor
Schwartz, social
- $11.000-$15,000
(sdninistrstion)
swanson. psychiatrist
- $27,500-335.000
sslsries are consistent with the sslsriss now in

Sibonoy, resenrch

N“

-

EEEEEE

(by negotistion)
$9,000-$13,000
$12,000
$6,800~$9.600

force at tho Haw York Mbdiosl Collogs, whose sslsry ranges
have been used to nogotints sslsrios for the Assooistion.

'4‘?"

I trust this information is useful.

A
.,
w.

-A

«

Sinooroly yours.

ivwwur

)

Mb:

Fink.

M.D.

Exeoutivo Director

mrlia
Eno.

�</text>
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                    <text>u- 'm“ n»...- w—
.A

1333-5183):

hbnnry 6th,

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Yon”,

T0!

8128211.]

m”:

m Fink, NJ).

8W:

Departmental

1913

”.13.

Ming

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muting
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M

cannot attend the
February 8th.
I had

many, to locturt 81:.
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5

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15"."‘nlvai'Pk'

q;

7383-53083

February 15th, 1973
TO:

E

FROM:

.3th

1'.

Gone M.

smith. Mad).

”fall“.

24.1).

m Fink. Md}.

1' have read the
publimum of 132-. 83111211, and his
emiculm vitae;
If. is difficult 301- m to envision an active mew
19
far Dr. 831th at this timu E1: 1mm.“ in opiatan
in their analgesic componmt, and in this ha in

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a.

docs not have the exparimee which vault! be
programs in treatment. or :1:qu of
eluted opiate angina-nee and multimsubstma abuse. Thu
closest 1: the
or ”Antecedents of toms. drug an"
(WW9). This is an 13:99th magma which my ’0. of

export.

our

mam

am

we: the impression that tho
tannins capable of undertaking
drew
and should we with
1::

inter-at. Homer, I m

university

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their participation

«Wat's: teaching or mesmh. could we not. get
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247/13

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                    <text>~13

r'wwm'vé‘rw:

7%8—56183

mu 5th, .1973

9'75“”

am

-o.‘1-,:ad'm-

«re

yaw-7‘

'

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You“.

To:

Stanley P.

W:

m Fink. 24.1).

SUBJECT:

Norton 0.

miller,

Md).

35.1).

—-‘mw»§-w

I an planned ta write in support of the recamendntion
for “mm: for m. marten Miller.
Prior to wining this faculty, I had occasion to work with
Dr. Miller when ho was an administrative leader at the Nation's.
Instant. or maul 3.51%. in mm role I foam! him unusually
tnumgont. innovative, and sensitive to social 153m; of
mental health.

emit:

E

81m. Joining the faculty last
I have worked with
number of comittees.
in the training program and can awar,
On each occasion I he.” bun impressed. by his induatry, enthusiasm,
smdrill. and; his ability to bring ta both the taaching and

him

aspect: of our work, a brand perspective and s
Maintain“
sensitivity.
Wedwith enthusiasm. accepted the challenge of the teaching
He

._

.,

~.

.‘

I

am

pleased to recommend him far consideration for tenure

tin was or the Stat: University or New Yam-y a. I
conﬁne“ mm: In is nrioualy counted to teaching as a
under

and
V

to this mimityc

mm

an

cum,

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"hazwm'ﬁ-lvf?

/
n

.

HEB-577A?

Lurch 12th. 1913
To:

sunny 1'. You”,

mm

ﬂu: Pink.

mm:

American

$.13.

194.1).

Pswhcpnmmsiul uncut-Men

m

Dr.
ﬂak was eluted President or the Algerian Psychoputhologictl Auceintien at in: annual meeting in March.
Inoculation in in its 5%}: you and has 0. Worship 01'
.250 pmhiatgviats, pmheloguts and kingdom scientists who
met madly ta discuss mutton: or the relation of

m

to behavinr. The 1971: topic: in
evaluation of payeholasictl modiﬁers at behavicr".

psychology and physiology
"An

Dr. Max Fink is Professor at Payehiam 1n the 3mm:
acumen Center and investigator 1:: studies at the mutton
or mmphyaiclogical mum-ea to hehavior, and muzzle
antagonists in the treatment of opiate (immense.

13/13

�</text>
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Much 27th. 1973

mu»,

we:

Manley F.

FROM:

Ma

mm:

Window: Coutmt

Fm,

24.».

14.13.

handing the roply whieh in mm for:
3.. Ho ”upon".
2. All the mad: at m nm are and for
rumination. Aw mum}: activity is financed

and
tram
by

Univunity funds.

3. no momma.
1;.

(a) For 1973-73. in have

«may to member;
has 105-4105 capacity. Our

at

891

capacity. [Capacity ..

1205

man

utilised the

beds of

me

and now
{mam-hm;
pmjmuon for April-Jam is

1005

21

m].

For 191'3-73 we are projccting 219-30 bod:
aver capacity being housed in mm man.

- the

staff visits: Putin“ visiting staff as
Mystique: ammc BS-BO/vnk at this time, increasing to
80-100 by June. For HTS-7%. we: anticipate 100—150 cm
visits/wok.
(b)

(a) Contrmt

am:
am.

visitu

to Dr. 8. Kieth:-

new in date. and none projected.

�</text>
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                    <text>\V

-'

w‘rv-«mwm

a
17

«Qua-"m

W‘dw—"ﬂ

73SB—616

April 9th, 1973
To:

Stanley P. 1911‘s,

FRUM:

M31

SUBJECT:

Lester Shapire,

Fink,

M.D.

M.D.
M.D.

pleased to reeoumend Lester Shapiro, M.D.
fbr promotion to Associate Clinieal Professor in the
Department of Psychiatry.

I

am

Lester since 195h. At that time I
eetive in the Nassau Heurapuyehietric Society,
the district branch of the APA. Lester was one o! the
principal leaders in that organination, end it was
largely through his efforts end encouragement that I
assumed an active role, leading eventually to the
Presiaency in 1959. Throughout that period or time,
and subsequently, I found Lester's advice to be logieel.

I have

became

reasonable,

known

and

his

Judgment

excellent.

Subsequently he took an active interest in the
In the county he has always ahnwn an
interest in the training program: for General Practitioners.
I have known him es e preetitioner, to whom I have
referred eases, and Iran when I have received enquiries.
In such clinical eitﬂetienu his Judgment we: excellent
and his point or View eeleetie.

APA

itself.

During the pest six months I have had numerous
oeenaions to discus: our training program with him.
Again, his eeleetie liev end good judgment has been

repeetealy aennnstreted.
In

I believe him to be a fine elinieien sad teecher.
mind he satiet1el all the requirements or en

my

Antoniaxe Clinieel Proteeeor.
MFI13

�</text>
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                    <text>“ﬁr-trawwwmx!

zvc-rmn

«:1

‘

.«

7353-635

April 23. 1973

Yell...

To:

Stanley F.

13014:

”M Fink, ”6D.

SUBJECT:

Hbdifion&amp;1on

M.D.

er Esau

2312

Enelosod 1: a drawing prepared

at our ruqnast by

his couwartarl at the rhoilities Plnnning
modification of room 2812 an three
the
affine. In:
simple ldboratory apaeea far phyniologieal recarding.
R. During and

principal elqmentn are walla. modification
of ‘1r handling. lighting (which is incandescent rather
thin fluﬁraacent), and a change of electrical wiring,
such that each roam is on ; separate eiruuit breakur.
The aatinnﬁc is $1.500, and from my past experience
should be quito aeeurate.
The

Please advise us to any further si§?a.

ur/13
Baa.

�</text>
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                    <text>m...

War:

a:

.--.;...As.,;:»

g.e-

Trim-63h

Hodical Lieansing Basra.
atate a: New York.
Twin Tavuru. 18th Flaor.
99 Wishinsten Avenuc,

Albany. R.Y. 12210.

Re:

E.

Pitts

M

B.

Gantluncn.
am Flttlcd to vrita on.bchalt at Dr. Bbrman Fitta.
I hurt known since 1967 in his many roles of increasing
responsibility in ¢liniea1 research at Pfizer. Inc. As a
consultant, I huvn had many opportunitiou to meet vith
him, to unseat nadiaul studios and cat: with him. and
becaun aaqnainted with his knovledgo of clinical madicino.

when

I

Dr.

Pitt. is

an outstanding

cliniciin, with a

keen

interest in and aunrcnall of the yrohlqns of patient
care. dingnosis and trontnnnt. Ra in warm. friendly, and
congenial in his interpersonal relations. and ralidbla
and thn'ghtful in axercisins his professional responsibility.
In I? relntiunlhipu with him, I 3&amp;3 reflect on no oxpcrionao
or quality of personality that would limit hi: full
endorscmnnt fbr licensurc in medicine.

I an pleiscd to undorle his applicatian without
reservation.

v-

Singeroly yourt,

aﬂ.7=:l__";"

'5
.2=),v,:

Jan

mm...”

Fink, M.D.
?rofnsaor or Ptychigtry
Mb:

MF/id

�</text>
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                    <text>"Tamar-n

._

non-um.rn.-acxuw

.
—

.

,

7383—6336

April 2h. 1913
Richolas A. Face, M.D..
250 East 73rd Street,
ﬂew York, N.Y. 10021.

Dear Boater Paee.
n

‘
.

an;

.m;r4vnnwxl

Your lettar is in error a I have not acccgted an
invitation to participate in a meeting st Dr. Campbell's
hamo; and t: I am not a voting residsnt in New York city,
suggest you not list me as a participant, supporter,

contributor, or cantultant to the

Biaggi.

campaign

of

Mk.

Sincerely yours,
r'

~

:—-7—

"-wn—I-u-

Mn: Fink, M.D.
Professor of Psychiatry
HIP/13

�</text>
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«W‘~«.

v-Iwmt -,

me...

».n;, n

w

-

1-...

7313:09601'

April
Alin Giles,

2%

. 1973

M.B.

Scientific Development Group
E.V. Orgsnon
Oss, Holland
Dear Alan,

I have the two tapes and have put them sside until
data for you.
record
can

we

Dr. Lange's problem with subjects becoming so sleepy with
the low doses of dissepan is most interesting. In our heads, doses
up to 10 25 here been well tolerated and only rarely have we had
subjects descend into stage 3~h sleep, to be undisturbed by the
buzzer. Usually we have allowed these periods to continue to the
end of the fifth minute, when the subject is alerted by verbal
cues, with the request to open his eyes for ho seconds. If this
is unsuccessful, we have allowed another period (up to 5 minutes,
but this has occurred only ones) when verbal questions are again
tried-~ if unduecessful, the experiment was terminated and the
session repeated a week later. My staff can recall only a few
such occasions-— with dissepsn 10 mg; doxepingHCl, 25 mg; and 20
mg imiprsnine.

ours,

we

Should it prove that his subjects are more sensitive than
should investigate the phenomenon further. (What is the

ambient temperature of the room 1 How active is the air circulation
during these experiments~~ could the room he considered 'stuffy'.
encouraging sleep 2)

we

I have already cabled my willingness to use 10
have already carried out some pilot studies without

mg

amitriptyline--

difficulty.
trip is as yet

are you coming to the U.S. ? My own
Shapiro is leaving this week~end for s meeting in
when
and
we reached Jim Porsek, he indicated he would
Switzerland,
meet Don there. I am awaiting approval from HIMH for our Greek
extension before scheduling a return visit. Will write as soon as
when

unscheduled.

I

know.

,

My

Don

best regards.

Sincerely yours,
Max

Fink,

M.D.

�</text>
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April 2”, 1973
‘1.’

Mumzv—P‘C-

E

h

K.
MW
850

W

Hernia, Ina...

Avenue,

N" Tart. 8.1.

10022.

E
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i
g.

1a

n. in:

ac

Wm,

difﬁcultiu with
am Wedwhiah
maimed and
an"Drugs,
Bonnier”,
bu bun
m,
1
in
the
«£15306. Booth 320
man.
mm
V111 be unable to
we
exhibit
that
this
up“
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It the an mm.
the

‘51.

ambit

M:

APA

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Mu:

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manor
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UM).

ot

mum-y

�</text>
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                    <text>7383—637

April 2h, 1973
Mr. James

J. Eberlein.

Pfizer IMug

235 East hand Street,
York. R.Y. 10017.

New

Dear Jim.

It is with rcgrct that I reqnnut withdrawal of
thn exhibit ”Drugs, EEG. and Behavior” tram the APA
ﬁhia year. In reviewing tbs material which we have
submitted, I have bacon. concerned that the information
praaented could be misinterpreted, and not enhance
our pwogran.
I

am

moat

grateful for your

many

excellent

suggestions 5nd the support whieh yen have given

prosoet.

this

I hnvc taken thn liberty of notifying the APA
ottiee and am analosing a copy of my letter to them.

Again,

my

thanks fbr your cooperation.

sincerely youri.

Fink, M.D.
Professor of Plyohiatry

Mix

ur/id
Ens.

�</text>
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                    <text>ram.

&lt;

L-a

wv

amp:-

run-var

:w

:91va

Wr‘ﬁrﬁrx'

Arm-w

73513-638

April 2”, 1973
Professeur J. Cadilhae,
Faculte de Medecine d9 Montpallicr,
Pathologie at Therapeutiquc Gannrulcs,
Institut de Biologie,
Mbntpellier, France.
Dear Frofelaaur Osdilhne,

Since receiving your letter of Januury 22nd, I
have fbund that it would be too difficult to provide
the exhibit which I baa planned to make at the
International Congress in Septeﬂber, an&amp; I am writing
to ask tau to withdruw the abstract and the ezh1b1t¢

I look

Harseille.

forward to meeting you nevertheless, in

Sinceruly'yours.

MAX Fink. M.D.
Professor of Psychiatry

NF/id

�</text>
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