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30 ﬂovamber 1973

Iver P. Stall,

M.D.

Departmnnt of Psychiatry

University of Indiana
School of ﬂcdicine
1315 “out 10 Street
Indianapolis, Indiana 66207
Daar twat:

In talking to Jaye. I indicated that I had not received
corrected
your
gallay. I havc corractod the duplicate and I
am sending you a Xeroxad copy which permits you to check the
corrections which I an suggontina. I would be grateful if you
would glance at chase pagan and crop an n.11ne an to whether
the suggestions are similar to chose mods by yourself, as wall
as any addttional counonts.
my

best regards,
sincarely yours,
Max

Fink. H.D.

yrofoesor of Psychiatry

HF/cia
Encl.

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11 Doccmbor 1973

Thelma Jonas, M.D.

8

Harvost Drive

Scaradalc,

New

York 10583

Dear Thelma:

Pleaaa accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Micropolitan
Hospital. I have found your enthusiasm and cooperation invaluable in supporting our explorations into new usos for untried
drugs. Without your help, our evaluation: of onloxone, onloxono
pamoate, lcvomochadyl. ctclazocino, and many others would not
have been successful.
'

My

boot wishes for the health of your family and the suc-

cess of your practice.

Sincoroly yours,
Fink, M.D.
Professor of Psychiatry

Max

HF/cia

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                    <text>Hf.

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mm‘=‘r=u&lt;'wv"‘?'m

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_
—

11 Doonmbor 1973

Horvoy Blnootono. M.D.
Chairman, Finance Committee
American Psychiatric Association
Council of New York Stat. District Bronchos
420 East 76th Seton:
Now York. New York 10021
’

Dear Harvey:

Euclooed is a check in the amount of $500.00 from Mr. Sidnny
Gimpol on bohalf of Sandoa-Hondor for the 197k divisional wanting.
I would be grateful if you would acknowledge recoipt directly to

Mr.

thpol.

I reztot thot I could not nttond the matting of
I trunt ovorythtng to woll.

Beaumont 11.

Sioooxoly yours.

-

«ﬁavve-vvww

ﬂax Fink, H.D.

«v.

,

Yrofosoot of Paychiotry

(wuuw.

MF/cis

,wrkgg'm

.

.
turn-W

Tm».

“C1

0

1‘

-'

'

'

‘

v

'

‘

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"'7‘"-

�</text>
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                    <text>731-8031

11 Decamber 1973

Dr. Dinahaw R. Doongaji

3rd Floor
Bombay Mutual Terrace
Sandburst Bridge
Bombay 7
INDIA

Dear

Sir:

International Association for Psychiatric Research,
Inc., is not a membership society. The Association supports
psychiatric research through grants and awards for fellowships.
The

Thank you

for your inquiry.
Sincerely yours,
Max

MF/cis

Fink,

M.D.

�</text>
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            <elementTextContainer>
              <elementText elementTextId="57832">
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          <element elementId="48">
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                  <elementText elementTextId="106796">
                    <text>73SB-8OSSB

11 December 1973

Laurence V. Faye,

Jr.,

M.D.

Assistant Chief Medical Director
for Acedmic Affairs

Veterans Administration
Department of Medicine and Surgery
810 Vermont Avenue, N.W.

Washington, D.C. 20420

Re:

112F3, 3 December 1973

Dear Dr. Faye:

for your invitation to participate in the V.A.
Orleans. I regret that I was unable to attend,
returning herewith the letter of authorization.

Thank you

meetings in
and

I

am

New

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

�</text>
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          <element elementId="50">
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            <elementTextContainer>
              <elementText elementTextId="57822">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          <element elementId="48">
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              <elementText elementTextId="57823">
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                  <elementText elementTextId="106795">
                    <text>7BSB~8IOSB

11 December 1973

I.

.

A

“Hug—M»

“.4

Mslbourne Greenberg, M.D.

88 South Bergen

Freaport,

New

Place

York 11520

Dear Mel:

”ﬂu—7",

a.

f
{

;

I have read your son's transcript

and wonder why he has

not applied to this medical school. I inquired and they are
unable to find a record of his application.

I wish

him the

best of luck.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cia

�</text>
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          <element elementId="50">
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".mevu'

7388—80983

.mm-wvr—

11 December 1973
«rm

—

»F-.

v.

"ILVU

'

I

Mr. Robert Cuddihy

Sandoz~Wander,

East Hanover,

Inc.

New

Jersey 07936

Dear Mr. Ouddihy:
About two years ago I presented some data at the Drug
Information Association meeting. I was assured that it would
be published in a forthcoming issue of the BIA Journal. When
I had not heard from Frank Liaka, I write to him and in his
answer of June 22 he indicated that I would hear from you.
The information presented at that time has already been
published elsewhere and I wish to withdraw that report.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis
Encl.

�</text>
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wvnmzm

.m—

”-1-."va

.,

WW"

:‘

7383—81153

11 December 1973

Grass Inotrumnnt Couynny
101 Old Colony Lane

Quincy. Haasachusetts 02169

Att.:

Hz. Lunacy

Gentlemen:
WOuld

my

oifico

you please ship 24 tabs: of EEG electrode paste to
at Stony Brook and bill tho Internationnl Association

for Psychiatric Research.
Many

thanks.
Sincerely.
Fink, M.D.
Professor oi Payehiatry

Max

MFfois

�</text>
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                    <text>'
UV“

’nnr'anr—Wvlr'F-‘er'v

-

V'V'wvv

Hun-w"-

rim-r

'nr

«av-:vs'w-"Jv-rv,

r-‘m-(r-V‘"

wowyrm—r-

-

»-

-;—.-rr.—

,

rgr-

,

»

r

:

:u—H

«mean—p"

u..- urn".

~

cm 1

.

"awn-11"- ‘s'nVva

no.0.

Hwy—y... --—-‘&lt;1wa—1\.~--~7-

........~,.-‘.'..,.”

~.

.vp

,

H.

,

V.

_

,

7333-81253

11 December 1973

William H. McGlothlin, Ph.D.
Department of Psychology
University of California
405

Hilgard Avenue

Los Angeles,
Dear

California

90024

Bill:

I received your card requesting a reprint of our studies
of chronic hashish users in Greece. The abstract which appeared
in Egychogharmacology Bulletin was in error, for I assumed that
that discussion was informal and would not be published.
Castes Stefanie and I have agreed that the material now
being completed will be aummarized in a series of reports ema—
nating from his laboratory early next year. When those are
available, I will send yhem to you. In the meantime, we have
been delighted with the data, which demonstrate a variety of
long~term effects of hashish use which seem to put this drug
back in the pharmacology texts as a psychoactive compound ﬁlth
the usual dose response characteristics, active CNS effects,
high penetrance to the CNS, and moderate rates of tolerance
development.
Thank you

for your inquiry.
Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>_’.~.Wr~a'va.
§&gt;

.

mu.

..

MN.
.

,

.v

V

.

.

,..

‘

,- .r

. .».~

_

n

..

,

A:

Viv

:zm

,

.-. we; Mucus

-

7v.

.~_~

.

- ~~

--

an..." r .

.w ,.

é:

7333-80853

11 December 1973

Thelma Jones, M.D.
8

Harvest Drive

Scarsdale,

New

York 10583

Dear Thelma:

Please accept my thanks for your long and helpful service
in the evaluation of narcotic antagonists at the Metropolitan
Hospital. I have found your enthusiasm and cooperation inval—
uable in supporting our explorations into new use: for untried
drugs. Without your help. our evaluations of naloxonc, naloxone
pamoate, levomethadyl, ciclazocine, and many others would not
have bean successful.

best wishes for the health of your family
cess of your practice,
My

and the auc-

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

W

�</text>
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-‘
'

7383-80783

11 December 1973

Federation of American Scientists
203

Street. N.E.
0.8. 20002

C

Whahington,

”xv-"mum“

Gentlamen:
m

"Wm-

I

would

Good

like to resign

from membership

in the

PAS.

luck in your efforts,
Sinceraly yours.

War

,_,,m-..wrm_

Fink, M.D.
Professor of Psychiatry

Max

:

MF/cis

�</text>
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13 December 1973

Sidney Marlin, M.D.
Rsaosrch Division

Station H
Csntral 1011p,

New

Ybrk 11722

Dear Sid:
Thank you for continuing to send your reprints. The
latest on psychopathology in methadone is of special interest
to Don Swanson.
to us and I hsve sent

it

I would spprscistc your changing your address of record
from New York Msdicsl Cellos: to Stony Brook.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/oia

�</text>
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g;

‘uvn‘l:pr‘w-r:lv~wv

4

www&lt;wwww

7358-81783
13 Decsmbsr 1973

Joyce G. Small, M.D.
Lsruo D. Carter Memorial Hospital
1315 Host 10th Strsst

Indianapolis, Indiana 46202

Dear Joyce:

the

I have submittsd the protocol for the study of 01-63 to
As I understand the regulations, you may procosd with

FDA.

this study since this is a supplement to an ongoing IND. As
soon as I receive the acknowledgment of receipt, I will send
it to you.

any I ask that you send ms 3 copy of the conssnt form that
you are using for this study? Also, pould you indicate for my
records the name of the committee and the dste when this protocol was approved for study at your hospital. I need these two

bits of information for
my

my

records only.

best regards,
sincerely yours,
Msx

Fink, M.D.

Professor of Psychiatry

MFZois

Enol.

�</text>
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                    <text>V‘W-u—Im.

‘21.:

.wmvmx.

~

y

rswrwvwr a“;

-

.

imm 1W

,

.uuo-m mar-u
7

,

-

*‘--'rv&gt;'v-vr.

"..mm.jnlm»any. my“. «yen-V

-V1u:wg-1m~7‘g' A...

.

. In”
.
.rrnrwmr’l-

.

guy-1‘5.

r

.v.»

we.“5“.7,“.
.

December 17. 1973
Dr. Alex
Old Post
Rye, New
Dear Dr.

Carlen
Road

York

Carlen,

.—

lb."

M

Wm,

r—w—w-m

.

.1..."

-mmwvmmw—

A,

e,

.
-

'Lefkowits

I

pleased to recommend the elevation of Dr. Henry
in the American Psychiatric Association.
fellowship
to
am

Dr. Lefkowits was a resident in psychiatry at Hillside
Hospital in l957~l959, and then remained at the hospital for an
additional three years as an attending psychiatrist. During that
time he was active both in the treatment of patients and the train»

inig of residents.
of my division.

He

also participated in the research programs

Since leaving Hillside, he has been in active practice
in Uestchester. From time to time, I have heard of his work; most
recently, in his role as consulting psychiatrist to the elderly
at the Guild for the Blind he has worked actively with my mother
who

tas a social worker at that institution.

In these relationships, I have always found Dr. Lefkowits
sincere, dependable, and considerate. He is a fine physician. In his
recent interestiin community activities, I believe he will make the
contribution which we would expect of Fellows of the A.P.A. I
endorse his promotion and election without reservation.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Fellow, APA, '51
Former, President, Nassau

NP

Society

~

.

—

�</text>
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                    <text>.w.m.y——W.,ﬁ,¢._

"rum—y.

“LNJ'W‘s—rr

.w

u:

7‘va

rﬂ-vtrll

-

..
~.

73SB~819SB

18 December 1973

Dr. P. Borunotclu
Laboratoiro do Psychopharmaeologlo

Hourophyoiologlquo

Hopital Psychiatrlquo do

Villajulf (Solon)
FRANCE

Door Dr. Boronstoin:

I have recoivod your reprints and thank you for thinking
of no. I think tho ayatomatio nature of your studio. with the
bunnodiaoopinos to very helpful, for we or. now automotins to
rolato 386 changes with blood levels.

I am taking the opportunity to wish you the boot for 1974
and to tell you that 03:11.: this your I moved my laboratory
from the ﬂow York Modlcal 001103. to Stony Erook. I would ap-

precitco rocoiving any othor roprinto at this

now uddrcno.

Stnooroly yours,
Fink, M.D.
Profoooor of Psychiatry

Max

MF/cia

�</text>
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                    <text>..
«r

J».,,_,‘__..,..V....

'

73SB~81883
m‘mwwmnavu-WF'

19 December 1973
‘3
‘

—

11mm

1.7mm

~v-v«'-vo~"!01"rr

.W'Vinrvu-grm—«w.

Julian J. Leaky,

Ph.D.

Executive Secretary
Clinical Projects Research Review Committee
Division of Extramural Research Programs
National Institute of Mental Health
lOCZS--Parklewn Building
5600 Fishers Lane
Rockville, Maryland 20852

Room

Re:

'5'"

MB

25608-01

A

.«—

»-

7"

gq.
w,

Dear Jack:

I have read the proposal,

"EEG

and

Changes during PsyDr. Reilly proposes

VER

Reilly.
psychiatric patients (N - 24).
In addition to a psychiatric evaluation using rating scales for
mental status, he proposes a systematic EEG recording for back—
ground EEG by visual interpretation, and for the visual evoked
response. Recordings will be done prior to drug treatment and
at weekly intervals for the duration of hospitalization, for at
least six weeks. He also proposes monthly recordings thereafter
between the second and sixth months. The date are to be snalysed by complex statistical procedures of a multivariate type
by consultants who are experienced in statistical analyses but

chiatric Treatment" by Dr. E. L.
to examine a small population of

not

EEG.

The mission set by Dr. Reilly is a most commendable one.
the problem and
My comments can be divided into four sections:
and
conclusions.
methods, facilities, significance,

1.

Problem and Methods

The problem selected by Dr. Reilly is a significant one.
In the description of the EEG recording and visual analyses,
he describes acceptable methods reflecting his experience as
an electroencephalographer. However, to describe a project in
1973 using visual description methods of a decade earlier may
reflect a lack of experience with newer methods of EEG quan—
tification. If the choice is based on data, then he should

~'»£Jﬂ'M"w":/“I

-1-

�.-

.....A.

J. J. Leaky,
explain

problem.

I

-2-

Ph.D.

why he uses

19 December 1973

non-quantitative methods for a quantitative

concerned with the diagnostic criteria for psychiatric
It is unclear whether Dr. Reilly has the experience
to select patients carefully, as the problem requires. (This
question should be answered in a site visit.)
am

evaluation.

I am also concerned with the one-to-two-day drug-free period
prior to the initial EEG. Considering the wide use of drugs,
varied dosages, etc.. this is inadequate. I do not have a good
solution, but I would recommend placing all patients in a defined
group on the same medication for a specific period of time before
the

EEG.

issue of diagnosis—related EEG measreported that the die differences were
a more parsiménious explanation of the differences found between
schizophrenics and depressives. Dr. Reilly does not indicate
an awareness of this major pitfall in such research.
ures

When we

some

examined the

years ago,

we

Thus the issue of quantification, psychiatric diagnosis,‘
medication and age controls, in addition th the small sample,
make me question the likelihood that the goal will be reached.
The application is also unclear as to whether VER, or resting
are the foci of the study. The application lacks a specific
hypothesis reflecting potential effects in either measure.
EEG,

2.

'Facilities

The physical facilities seem adequate to the task, although
I anticipate that Dr. Reilly will find that recordings made on
a Becknsn recorder will not be satisfactory for computer pro,

ceasing.

”n“...-

.r,

:y-rvlcn—‘vr

«mnp-

.r.

”,1

”WW,

wwwme

1“,.

rm—

Dr. Reilly's training seems adequate for EEG and his coworkers are physiologists and statisticians. The participation
of a psychiatrist (a behavioral typologist) seems lacking in

the study.

'

The funds requested seem unusually modest. Considering
the talents ascribed to the consultants, the sun requested
($3,000) and the computer tine ($600) are inadequate for the
analyses described in the text. While modesty may be a factor,
I believe lack of experience is a better explanation.

�J. J. Leaky. Ph.D.
3.

19 December 1973

~3~

-

Significance

of physiological indices for the classification
of the mentally ill and for the description of changes in psychiatric treatment are very important issues. The problem has
The problem

been approached by many investigators.

The

literature survey

presented by Dr. Reilly is adequate, although there are significant omissions, particularly the studies of Shagass, Callaway, and Monroe. Again, the references to clinical electroancephalographers, especially those associated with Knott, Wilson, and Doty, are well reported, but the contributions to this
problem by psychopathologists are lacking.
4.

Conclusions

cannot help feeling that Dr. Reilly is an enthusiastic
in climbing a small hill in the lower
Appalachian Mountains, who became excited with the possibility
of scaling Annapurna. The goal is commendable, but he seems
to have learned only the rudiments necessary for this task, and
1

young man, experienced

I

do not

believe that the prognosis for success is favorable.

But how can one encourage such an

sible to

recommend

that he spend

it poswith Callaway,

interest? Is

some time

Shagese, J. Small or Itil to obtain additional psychiatric
experience relevant to the problem which interests him?

I would also suggest, if one can, that he become acquainted
with Neil Burch and Peter Kellaway, both in Houston. These men
understand EEG measurement and can probably contribute to his
data processing. He should become acquainted with either Bernard
Salteberg of Tulane or Stanley Feldstein of the University of
Maryland. Both of these men have devoted many years' effort to
the statistical analysis of complex EEG data, Seltrberg with
Burch and Feldstein with me. (I would ask that he be advised
of the work of Dr. Burdh, for on Page 21 he says, "There is no
other source of the programs in running form available in Houston."
It is my understanding that Dr. Burch has had quantitative EEG
programs for background 339 and probably AER in running form
since 1966.)
'

I trust these

comments

are helpful.

I believe a

be encouraged to climb mountains when he has had

man should

sufficient

ex—

perience to handle these problems-~for climbing the mountain that
he has targetted is a worthwhile experience.

�“0 “a, -m.
w-

‘

._.v,,.‘

A

,.

&lt;

.

V.

J. J. Lalky, Hub.

-4-

19 Dgcambat 1973

u,v

..

.

Thank you

Sinceruly,

.v-:rw.&lt;wmn—vu_.-—.A..Y....

Fink, MOD.
Prafansor of Psychiatry

M‘x
-.wr7l=r

a,”

H

for the opportunity to rcviaw this application.

Hrfcis

M

�</text>
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                    <text>'i

WWWA

.2:

02

73AP-826AP
20 Docnnbcr 1973

Garald L. Klerman, M.D.

Suparintandent
Erich Lindcmann Mhntnl Health Cantu:
Government Cents:
Boston, Mhasachuactts 02114

Duar Gerry:

records are incomplete, but this lettar from A1 Freadmnn
suggests that no rcviov the £110: for an invitation to Dr. June
Christmas.
my

If aha was invited, pcrhaps thc Mbmberahip Committee would
reconsider extending anothcr invitation.
Ifisho has not bocn nominated, perhaps w: can write her,
taking for but C.V., and thnn proccsl it with letters of rccom~

mondation from.A1 Ergoduan.
My

bcst ragards,
Sinccrnly yours,

m Fink. Hobo
MF/cis

�</text>
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                    <text>73AP-828AP
20 Doccmbor 1973

Jonathan 0. Cole, H.D.

Temple University

Phlladolphia, Ponnoylvania 19122
Door Jon:
At the ACE? matting

1t ocomod important to provide an apportunlty to respond to the proposed policy concerning resonrch
in man. I have sent the oncloood letter on behalf of the APPA.
that

you must ho involved with the formulation of
if would be possible for you to
present a proposed roopoooo on behalf of the APPA at the Council
wanting in March. I would be pleasud to work with you on this
and to out said. the tins beforo Council at your convonioooo.

tho

Knowing

ASH?

my

response, I wonder

it

best regards,
Sincerely yours,
Max

MF/cls

Incl.

Fink, M.D.

�</text>
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                    <text>73AP-827AP
20 December 1973

Diroctor
Hationnl Institutes of noelth
9000 Rockville Pike
Bethesda, Maryland 20014

Roz

Departoont of Health Education

end welfare
Rational Institute of Health
Protection of Human Subjects

Policies sod Procedures
Flgeral Register. Voluno 38,
Fridoy, Rovouber 16th. 1973

D“! Sit:
behalf of the Anorioon Peyohopathologiool Association. we
request an attention of ‘30 daye of; the time to reply to the pro~
posed polioioe noted above. This extonsion would permit us to
contider tho ieeuce roiood in the proposed soi‘olineu at our enuual oneting in March.
On

The proposed regulations are unusually important in that
they any iapair studies vital to the health of the citizens of
our nation. rathor than eneourege than. The issues extend be~
yond the imoodiate problems of monitoring the human rights of
children and the nontolly 111. Because an believe that the axonoies involved have sivon much thought to the production of these

it

bolievo it impossible for us, as well as others.
suidolinon,
to respond mooniasfully in the tow wueko einoo the policies were

publiehod on November 16.

If such an extension is granted, and I hope it will be. I
you will have e constructive rosponao from thin Association.

believe

Sincorely yours,
Fink,
President

Max

MF/oio

bcc:

Dr. Leo

Hollister

M.D.

#221

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                    <text>kWh-A

-»-—

mm,-

7'

rung-vwvwn

7383-82558
20 December 1973

Dr. Miles Matousek

Klin. neurofys. Lab.
Sahlgrsnska Sjukhuset
Bjukvardsfﬂrvaltningen

SWEDEN

l

Gﬂteborg

Dear Miles:

It

was very kind of you to send me the program for

Hjorth's
I have given your output to Dr. Shapiro and
he has promised to give me a Christmas present of the program.
Should it be running. I will obtain these measures in addition
to my usual frequency measures in my next drug study and, hops~
fully, should have some information for the meeting in April.
Should it be possible, I would like to visit your laboratory
when I come to Europe in the late spring. I shall probably be
accompanied by one of my daughters, and I will use the occasion
to see some of the sights of $wedsn.
analysis of

EEG.

Last month I visited Jiri's laboratory in Basel and was
very impressed with the organization, equipment, programs, and
enthusiasm of the unit. For the first time since 1966, I believe Jiri is happy and productive—~although he did complain
that he was tired of studying ergot and hoped that Sandor would
find a more stimulating interest.
Voita has assumed the responsibility of my former laboratory with enthusiasm and is doing a magnificent job. He has
apparently convinced the funding authorities to give him ad—
ditional equipment as well as to set up a laboratory in Copen—
hagen. I see him as busy as I must have been when I had that
position. There is something about life in New York City that
makes men run when others walk. Here, in the country, men walk
and I seem to have plenty of time to spend with my family, for

which

I

am

most

grateful.

�"a...”

Wyn-v,

.u-

Dr.

M1103

Matousak

Again.

that I will
My

-z-

20 Dtccmber 1973

thanks for sending me the programa, and I hope
have some outputs to show you in the spring.

my

best rusards for a healthy

and happy 1974,

Stncnrely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>.

"me'JF'I-wawwrv

w‘r—Awry-I-

7333-82433

20 Decambcr 1973

Costco Stefania, M.D.
Deparcutnt of P:ych1atry
Untvaraicy of Achcns School of Modicina

Bainition Hospital

76, Vasillilais Sophia Avenue
Athena . Gram
.

.
.

wrwgrgnmqgmw

Boar Cactus:

In chanting the informntion of ch: withdrawal data, an lack
tha drug node (a: Evnnaclidis and Ermidil. Can you pleas. tell
as tho code (A or B) for Station- 1~3 and 4-6 for each of abuse

MM

Many

,
a

thanks.

m
a",

Sincuraly yours,

Emma»

by

.
l"—

‘

HI: Fink,

'jt/‘rﬁf‘yy

lF/cia

ml

‘

‘

fijﬂ‘imr'ﬁ'v

»-4"'"',"W4¢:mi.fﬂ'

-'
{“91

f
TWWW“:

1-f-

f"
.1“?
‘

qsv

M.D.

Pro£0500t of Psychiatry

.3:

0

�</text>
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                    <text>7383m83h83

20 December 1973
M

E

M

0

R A N D U

M

To:

Stanley F. Yolles,

From:

Mex

Fink,

M.D.

M.D.

Subject: Guidelines for the Evaluation of Students

'i
-

we?“

.1“:

:
"1'17:

:H

I

have read the Guidelines, dated December 1h, with in~
terest. I find them acceptable subject to two comments:

1)

The_progrem depends on an active Committee
on Academic Standards holding regular meetings
with a senior person as chairman. I hope the

faculty understands that this is another inn
portant commitment of faculty time. Should the
Committee meet irregularly or should it serve
Eggbtorme only, I believe that both students
and faculty will be disappointed.
2)

It seems that grades will not be given. It
seems to as that grades are s shorthand way
or indicating to a student that he is either

perfbrming very well, well, acceptably, or

,....-»

poorly in relation to the faculty's expecta—
tations. I think that the grades should be
maintained, but nowhere is a grading system

v“-rrz-*'W"w-'z4—wr;.

explained.

5'
..

MF/oie

�</text>
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                    <text>7BSB~82983
20 December 1973

Peter J. Fell,

Fisooo, Ltd.
Loioeotorshire

M.D.
L311

OQY

ENGLAND

Peter:

Dear

I look forward to your visiting my laboratories at Stony
at January 17. I underetend from your secretary that you
will be arriving from Toronto. There are connections to two
Brook

new York

airports, LaGoardia and

John P. Kennoéy.

The beat way to reach the Buivereity

in

by lioooeine from

either airport—~travel time is 1-1/2 hours. When you arrive at
either airport (LaGuardie is 10 minutes closer). oak for the
neareat euborban limoueine telephonee and use the one marked
"Long Island Limoueine." They will give you the eohedule for
the next limousine to Stony Brook and you will be picked up at
the terminal, near that phone. -Tolephonee are at each major
terminal. The coat ie $15.0U.
You may

either take a taxi

from the limousine depot at
(The
from

call my number and I will pick you up.
railroad station and limousine atop are eight minutes
Stony Brook or

campus.)

Should

it

be poeeiblo for you to change your schedule and

arrive the night before,

you are welcome to etay

drive to Stony Brook with

airport at (516)
my

466v54ﬁ4.

me.

at

In that event. call

my home and
me from the

I look forward to your visit. My beet regards to Vi and
boat wiehee for a happy and healthy 1974.
Sincerely yours.
Fink.
m
Proteeaor of Psychiatry
MOD.

MF/oio

�</text>
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                    <text>‘

"‘KWWO‘G‘il-Ww

«ww‘

:q

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.v

a...

,

7

0-.

...

an“... “mammq. ﬂag—”y.

,

_

, ‘

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‘4'.

.

‘

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-.

.

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.

.,.

—..

\

,yyr

$1.”.

.7

p.

w...

n

W.

73SB~BBOSB

20

W

1973

Murray Winngr, I‘LD.

Merrill

Mamas

Amity Road

Cincinnati, (bio
Dear

45215

Way:

InfollmdngupmsmdjamImmmme-

gazdjngtlmaffectaofantihistminicagmtsmmsmﬂnmtby

mmdmummommafm

FadngonamBerry.
ofandhiatmhﬁcagentsmﬂpxwﬁemwimﬂmttheeﬁm
cf
antﬂziamhﬁc men can be discriminated.
My

(Av-WI:

best regards for a

may

1974.

Sincerely yams,

vrwmtw

n»

IP‘T‘.‘

-y—nu

.-

Max

Fink, Md).

Professor of Psychiatry

W/cis

V

�</text>
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                    <text>T3SB~83583
20 December 1973

Richard Wittsnborn, Ph.D.

Univorsity Professor

Interdisciplinary Research Center
Rutgers University
New Brunswick, New Jersey 08903
Dear Dick:

I am.utiting with regard to the ACNP~FDA Guideline Task
Force Report dated October 1, 1973. I have not responded to
that mailing earlier because I anticipated a meeting with the
group in Palm Springs. As that meeting did not take place,
I on taking this opportunity to respond with some comments.

I

three major sections carefully and, in
of the Introduction, believe that this document may be
used as part of the regulatory actions or the FDA. My com~
manta are based on this cvcntusl use. With this‘in mind, it
seems to no that brevity is a virtue to be highly commanded;
and negative ststemcnts, however,wcll intended. should be
View

have read the

carefully cxpunipd.
My

principal criticism of the documsnt, therefbrc, is
1 and 2, the Introduction and General Principles,

that Sections

are much too lengthy, much too specific, and contain a number
of pcjorativc ststcmcnts which may reflect the opinions of
the writers but should be rcviewod carefully. I believe that
those sections should be reduced to no more than a tow para»
graphs of introduction.

I note that many comments are made in the document which
ordinarily would carry with them citations. I am struck that
this lack of citations losses the reader with no recourse but
to assume that the statcmcnts are opinion and not based on
experimental tact. Nevertheless, there are many statements
which are based on czpcrimcnts and I believe that citations
should be provided.

�Richard Wittcnborn,,Ph.D.

—2~

20 December 1973

Guideline Statements, Section 3, seem well written and
clear.
quite
It is in these sections in particular that cite»
tions ought to be requested.
The

Specific examples upon which these opinions are based
follow.
Introduction (Pp. 3-5) contains such pejorative state~
as, "The ‘gold rush' into the manufacture...," and "This
possibility is already viewed with alarn'hy some drug houses'
research d1rectora...." Page 7, Line 1, contains an error, I
believe, that "June, 1950," should be "June, 1970." As an
example of the specific nature of the Introduction which is
undocumented, is the recommendation that certain rating scales
be used, such as the IMPS, BPRS, and WPRS. Nowhere does it
state the use to which these scales here already been put, and
the reader is left with a catalogue without any clarification.
Perhaps citations indicating those kinds of studies in which
these scales hare been used successfully would be helpful.
Indeed, a simple count of the number of studies each of these
scales has been used in might be useful information.
manta

The

Another example is the reference to psychomotor tests
(Pp. 21-22), in which it is alleged that a "Hacker Cube drawing or a reversible staircase drawing has been seen to increase

in response to effective anti-depressant medication." I do
not think that this statement would be substantiated by the
reference, for when we tried this test we failed to discrimi—
nate imipramine from chlorpronasine. Perhaps someone else
was more successful, and the citation should be given.

In Section 3, "Antianxiety Agents," I found a number of
gratuitous statements. For example, on Page 9 the paragraphs
on indirect verbal measures, indirect clinical measures, phys~
iological measures, and behavioral measures each start with
an assertion followed by an opinion. For example, "These
measures provide estimates of affective states and other areas
of function through content analysis of spoken or written verbal
samples from the patient, by carefully trained technicians according to procedures specified in detail," is followed by
"Although these procedures are less subject to some of the
distortions encountered in direct measures, they are difficult
and time consuming," The first sentence is useful; the second
an opinion which, if true, should be documented. I believe
the first sentence can stand in the record without the second.
This is true for the other three paragraphs as well.

I hesitate to suggest an addition, but it seems to me that
the section on Phase III studies (Pp. lh-l?) might raise the
question of the degrees of effettivencss of certain compounds

�’73--

,.

.‘

_..-,

-u

.7

e...

—w—'\:-m

.3-

Richard Wittenborn, Ph.D.

20 December l973

with continued use, i.e., "tolerance." I think this is an
aspect of Phase III studies that in important for the pro—
tection of the user.
On

Page 12, the

"Criteria of drug effect"

make no recom—

statistical prOblems involved in such
an evaluation. It is here, in particular, that the Committee
can be very helpful in providing materials to the academic community and the FDA regarding statistical procedures and their
pitfalls. Citations would be most helpful, particularly with
regard to the problems of aﬁpll samples, parametric and nonmandation regarding the

parametric statictics, and.multivariate computer analyses.
A note as to the meaning of levels of significance may or may
not be added.
Some

of the

comments

with regard to the anti—anxiety sec-

tion are equally applicable for the antiudepressant section,
particularly the need for references and guidelines to statistics.

In addition, the Opinions of the Committee are expressed on Pages
12-lh with admirable reatraint~~except Items 7 and 8. I hesitate to suggest that EEG measures provide evidence of efficacy
and indices of change at least equivalent to verbal aample techniques. Indeed, in the studies which I carried out with Bob
Khhn and Joseph Jarre more than 10 years ago, we found a greater
sensitivity to EEG measures than linguistic measures. I have
followed Lou Gottachalk'a data with interest but do not believe
that the distinction implicit in Items 7 and 8 can be substan—

tiated.

‘

Page 17 in Phase III studies, the Committee recommends
a comparison of new anti~dapresaants with tricyclica, MAO inhibitors, and psychomotor stimulants. It might be useful to
suggest that comparison of new treatments should be made with
On

the most effective anti~dspreeaant therapy available, that of
repeated induced convulsions (BC? or ICT).

I wish to

command

the

members

orally excellent set of guidelines.

of the Committee for a gene_
Sincerely yours,
Fink, an.
Professor of Psychiatry
Max

MF/cis

cc:

Klerman, M.D.
E. Uhlenhuth, M.D.
G.

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                    <text>7383-83783

20 DeceMber 1973

;

Jeroma Levine, M.D.

V
.

Chief

1,

”"7"

Psychopharnaoology Reacnrch Branch
ﬁctional Institute of Mental Ebalth

‘fW-I‘

nygw‘w,

5600

Fisher's

lockvillc,

5‘va

Lane
Maryland 20852

-:

Re:

m
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Dear

mmwv

MK

2hoao

Jerry:

I fbund our discunaions in Palm Springs concerning my EEG
program most helpful. I haw. reviewed the work now in progress
and I believe it would be better tbr an to submit a continuation
proposal fbr the May 1 dandlinu. This would permit me to providc

'I-z-

r-u
v
'n‘

“wwwsrmwmn'wr-rr

much

batter doeunontaxion.

Again, many thanks and
91'3"!"

my

best wishes for a healthy 197h.
Sincoraxy yours,

A

Fink, H.D.
Professor of Psychiatry

"

Max

”5‘21?”

ﬂylcin
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                    <text>.r.

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7383-83633
20 December 1973
Leo

Hollieter,

President

M.D.

American College of Neuropaychopharmecology

Veterans Annihietration Hcepital
Palo Alto, California 9&amp;305

Dear Lee:

vriting this letter in regard to the latest meeting
Firat, I vieh to commend.thc Arrangements Comp
mittee with their success in providing ideal weather and a
moat aalubrioue environment for the meeting. I hope the Council
will consider an annual return to Palm Springs with a high pri~
ority.
I

of the

am
ACHP.

I trust the painful ieauc or the invitees has been cue»
ceaetully resolved. I was embarrassed by the Council and the
Secretary, as were some other members of the Coylege, and I
trust this will not recur.
»

I am writing specifically to raise a qucetion with regard
to the arrangements. The registration the of $25.00 was tied
to a dinner and the free distribution of alcohol. Since not
all members of the ACE? drink alcohol, it seems that we are

subventing alcohol users and in some rather indirect way cn~
couraaing alcoholism. As a college dedicated to drugs and
their abuse potential. I believe we should be more sensitive
to the problems of abuse and not be put in the posture (even
it noble and fund~raiaing motives are involved) of encouraging
alcoholism. Alcoholics ought to pay their own way. I would
hope that the Council would make it possible next year for
there to be a separation between an attendance Ice and dinner
and alcohol fees.

more important reason for writing this letter
do with my desire to suggest that the Program Committee
consider a round table or symposium on the effects of poly—

has

Finally, a

to

peptides on brain function. During the past few years, a hunter
of scientists, both in the united Etntea and Europe, hare demonstrated that ACTH and M33 and their derivative peptide chains
may have central effects which are highly specific with regard

-1-

�goo

Hollister,

M.D.

«2*

20 December 197;

to functions of memory and extinction. Scientists working in
this field include Moaongh, Gold, Rustin, dsWied, Small, and

Esooan. my guest ax the ACNP, Dr. Bonk van Biases, in a phar»
mooologdst actively involved in this research program.1n Holland
and wort: closely with Br. David deﬁlod. At my suggestion,
Dr. van Riezun is willing to provide some of the funds neces—
sany to invite the purtioipdtion of scientists for such a sympoa~
inn, should tho ACE? wish to hold such a session and, secondly,
should its own funds be inadequate.

I thank you for the letter regarding the HEW regulations
and tho Eudoral Beggater. I have tent a letter similar to yours
on behalf of tho APPA-a oopy of which in anclosed for your
interest. I will be grateful
you would keep me apprised
of one evaluations of these guidelines 80 that I may be able

if

to present then.to a wasting of the Council and the APPA during
the first week in March. That will be in sufficient time if
the 90~day extension is allowed.
My

of the

best wishes to: the success of your tenure as President
and my best wishes for a hoopy and healthy 197h.

ACE?

Sincerely yours,
Fink, M.D.
Protozoa: of Psychiatry
Mn:

MF/ois

Encl.

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                    <text>7383—83283
20 December 1973

Gerald L. Klerman,

M.D.

Superintendent
Erich Lindemann Mental Health Center

.

._

.....

Government Center
Boston, Massachusetts 0211h

.

"w...“

Dear Gerry:

V...”

MW...

but

I

was

of your Committee at the FDA
especially pleased to read the write~up in Psychiatric

have heard of the work

I found the missions of the Committee of considerable
interest because the present methods of affecting change in
regulatory policy do not allow fer a regularized input from
news.

the academic community.

In this regard, I am taking the liberty of sending you
cepies of letters I sent to the FDA. These is much concern
with prdblems of drug equivalence and bioavailsbility. EEG
measures to record the central effects of psychoactive drugs

and studies done in this laboratory and similar laboratories
in St. Louis, Basel, and Goteborg provide optimism that these
techniques may be useful in answering questions to which blood
level measurements are now applied.

Should it be within the purview of the Committee, perhaps
you could consider a review of the ayaiaable data with an eye

to undertaking collaborative studies.
My

best regards for a successful

new

year.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

Encl.

L

a.”

,,

512‘

~

‘
3

,v

,

,

,

“$34-41,:

- i

.1

;... sillnnl i

�</text>
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                    <text>mam—:7

7333-83183
20 December 1973

Barrett Scoville,

M.D.

Division of Neuropharmacology
Food and Drug Administration
5600

Fisher's

Lane

Rockville, Maryland 20852

“um-”w.

vw-rvw»wv'w‘&lt;v€"“"

v
~/-‘

v

Dear Barry:

I am enclosing a copy of a letter which I sent Al Gardner
in July. In that letter, I was proposing to discuss the use
of quantitative electrophysiology to assay the bioavailability
of CNS—active drugs.
I think the methods are now sufficiently developed, both
in the quantification of EEG and the statistical processing of
EEG and behavioral data, to allow more extensive correlations
of data collected to assess such questions as the rate at which
a drug affects the brain, and comparisons of different dosages
and probably different fbrmulations for rate and degree of ef~
feet.
I

enclosing a preprint of a report which summarizes
our experience to December, 1972; and a reprint published in
1971 on statistical methods used to analyze rate effects with
intrawenous pehtothal.
am

Should the Division of Neuropharmacology wish to assess
these methods, I would be pleased for an opportunity to dis—
cuss the experiences and the potentialities in detail.

It

was fun

flying with you.

and healthy i97h.

My

best wishes for a

happy

r‘,-n-.n:

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max
.mvwmwﬁm‘mtﬂ?

MF/cis

Encls.

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                    <text>a

V-‘“

~V’

'-

arr-1r.

--r_v-x~wxmw.-v

mm

w

7383.83988
20 December 1973

Dr. Alexander Levine
Chairman of the anberehip Division
and Fellowship

Anericen Psychiatric Association
1700 Eighteenth

washington, D.C.

Street,

H.w.

Dear Dr. Levine:

I

Dermen

am

pleased to

recommend

to Fbllowahip in the

the promotion or Dr. Robert M.
Psychiatric Association.

American

I have known Dr. Derman fbr more than two years, first
in his role as Chief of the Addiction Service It the Manhattan
Veterans Administration and lately as Associate Professor in
this Department. During the past year I have worked closely
with him on e number or academic essignmente. In these relationships, I have elwnye found him to be friendly, modest, reliable,
and innovative. an accepts responsibility and he: carried out
the missions of the Department admirebly. He in e well-qualified payehietriet with extensive clinical and administrative
experience. In his present position, he is actively involved

with community education.

vw—x-

‘vzu-

v:
-

I am.pleeeed to recommena him for Fellowship, for I believe that he has already demonstrated the attributes of this

honor.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

:W—"mmwmw

EARA,

1951

President, Nassau (N.Y.)

District Branch,
MF/cis

1959

�</text>
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/

w”?

73SB~SZSSB

20 Docsmbsr 1973

Dr. Miles Mucousok
Klin. usurofys. Lab.

Sshlgrsnska Sjukhusst
Sjukvnrdofdrvaltuingou l GHtshotg
SWEDEN

Dost Milos:

It

for Hjorth's
I have given your output to Dr. Shapiro and
he has promised to give no s Christmas present of the program.
Should it to running, I will obtain thsso measures in addition
to my usual froqusncy mossurss in my uoxt drug study sud, hopsfully, should have sous information for the ousting in April.
was very kind of you to osnd us the program

analysis of

when

Should

I

come

EEG.

be possihls. I would
it
to Europe in tho

like to visit your laboratory
lsts spring. I shall probably ho

aooompanisd by ono of my daughtsrs, sad
to too sons of tho sights of Swsdsn.

I will use tho occasion

Last month I visited Jiri's laboratory in Basel and was
very impressed with the organisation, squipmsnt, programs, and
enthusiasm of the unit. For the first time since 1966, I beliovs Jiri is hsppy and productive-«although he did complain
that ho was tirsd of studying srgot sud hoped that Ssndoz would

find a

more

stimulating interest.

Voits has assumsd the responsibility of my former labors.
tory with snthusissm and is doing a msguifioont job. He has
‘spporontly convinood the funding authorities to give him additional squipusnt on wall so to out up a lsborstory in Copen—
hsgsn. I set him so busy as I must have boon when I had that
position. Thurs is sousthing about life in New York City that
makes msn run when othsts walk. Hora, in the country. msn walk
and I soon to hsvs plenty of tins to spend with my family. for

'whioh

I

am

most

grateful.

�1

.,

,‘vam v-vyﬁ n-.. -

v

V,

(Nu-um. u.

:

7,. 7'

.57

my

.. v

a

‘.

.,

..,

~.w.~...m_w y._l.,mr,. *vna” I

.7,

W,“ VY

V..-"

.W‘W...1v” . ..

‘

u— ..W V..\.,..

my-“ .. “wt, , _W.,.‘f.,_\-.m.

u

m

W"

bi. Milos

Matousek

mmwnwnqmw-v

Again,

my

20

—2-

December 1973

thanks for sending me the programs, and I hope
some outputs to show you in the spring.

that I will have
My

best regards for

a healthy and happy 1974.

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>Aux-=-

7383—83883
20 December 1973

Jovan Simeon, M.D.
Missouri Institute of Peyohietry
shoe Arsenal Street

Saint Louis, Miesluri 63139

Dear Joven:

I am pleased to cooperate with your date analyser and
look forwerd to receiving the cards.
As I mentioned, this Department is growing
very repldly.
here been notified of Federal.ewerda totaling more than
$1,000,000 for the coming year, in training and research, in
drug abuse, and in the peyohopothology of sex. It is highly
likely that this Department will be awarded e special grant
from the State to establish e research center similar to the one
in Missouri at the local State hospital. we eleo have the pos—
sibility of expending the program in mantel deficiency and
retardation at e local State hoapitel.
we

Recognizing your background, I took the liberty of dis—
cussing your credentials with the Chairmen or the Department,
Dr. Stanley Yolles. He would be delighted to here you visit.
Should you be interested in relocating to Rev York,

I

suggest you write him a letter telling him of your interests
end submitting a curriculum vitee. Your letter should indi~
cote that you are well known to myself and Mickey Taylor, who
in now the Director of Residency Training for the Department.
If you happen to know Joe wortis on well, I would indicate
far he is in charge of the mantel retardation program here. that,
My

m

best regards fOr a

happy and healthy lQTh.

.

Sincerely yours,

‘1'“:

«

«wpag—w—wr—vr

Fink, M.D.
Professor of Psychiatry
Mex

MF/ois

�</text>
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                    <text>m‘w’

mam

..

December 21, 1973
Henk van Riezen, M.D.

Scientific

Develbpment Group

N.V. Organon

Oss, Holland
Dear Henk,

When I received the lettee describing the placebo vehicle,
I read the available regulations. I found none that applied to
IND formulations. Nevertheless, I celled the men at the Division of
Neuropharmacology of the F.D.A., reached Dr. Edward Tocus and
discussed the problem with him. He sent me on to two young associates,
Drs. Kum Kumian and Thomas Hayes. None of the three believed the
question presented a prdblem.

I believe that the formulation is acceptable.
I will

Should you send the supplies to us in the present form,

file

an amendment

to the

IND,

stating that the formulations

used fpr the ongoing studies consist of the type you make available
to me, There will be no objection.

It is probable, however, that should 01—63 come to an RDA,
and you then submit the formulation with a coloring substance, that

the marketing reviewers

may

object.

it

have had severe winter storms here, but
warm sunshine of Palm Springs seems so
wishes for a happy New Year 2
WE

cold today. The
Our

best

is clear
far

Sincerely yours,

Max

Fink,

M.D.

away.

and

�</text>
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                    <text>TBSBGBhosB

21 December 1973

Fritz

A. Freyhan, M.D.

Editoruin-Chier
Comprehensive Psychiatry

Street,

2015

B

Dear

Fritz:
I have read the article

H.W.

weanington, D.C. 20009

by Btrauss, g§_gl;, "Inpatient
Alcoholics: Characteristics and Needs," with interest. While
the findings seem supportive of prevalent teachings and add
little that is new, I believe the presentation is sufficiently
well documented to indicate the special risks to which members
of some subcultures are prone. The need for additional attention by psychiatrists to the ubiquitous problems of alcoholism
is well represented. The article is well written, clear, and
deserves publication.

I have two comments. The paper lacks a dhscussion of the
work done by others and the citations seem outdated. carer-

tunately, I am not sufficiently acquainted with the literature
to define specific emissions but a question to the authors may
set their

minds working.

Secondly, on Page 8 the authors cite the APA for not at~
tending to alcoholism. I do not believe this criticism is
warranted. The program reflects what interests psychiatrists
in any year and a less 39.nominem argument is to be wished for.
Perhaps they could survey the nudber or papers sent to a group
or representative psychiatric societies (Society for Biological
Psychiatry, Ortho. American Psychological Association, etc.)
and reflect on the percentage of time devoted to alcoholism
at all such meetings.
Thank you

for the opportunity to review this article.
Sincerely yours,
Max Fink, 24.1).
Professor of Psychiatry

MF/cia

�</text>
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27 Dncaﬁbor 1973

Exact: Barenann. v.9.
810.9 Laboratory
Boston stat. Hospital
591 Korean Scrccc

Beacon. Haslschusutts 02125
DUI: Krutcz

I am writing to rnacmnund His: Ctrolyn Poinlct. who 1.
intcruntnd in continuing ha: ndueation 1n ﬂatten and may call
you for :dvleu s. an a paoltlan II a :uccarth assistant. 8h.
x:cdunc.d colby 0011.3: with ouncllan: srldun 1n Jana, 1972,
and has boon with an than: 9:0: 18 months. 8h. has pgrele1~
patod 1n thn work a! thin lnhargtary fully, including recording of EEG. procuaaing of 316 using tha IBM 1800, utntistiaal
nanlyucs and bohtviorcl cvsluntionn during human Olpﬂrtllntl**
all of thlit in Ill. voluntanta.
3h. 1: an attractive cal churning girl with auchuaiasn
1n u.nnt¢hnd by any of ch. many yuan; pooplc who hnvn
varkcd 29: up. 8h. 1: raltnblo and dnpandablo, and I rtcanw
Isud but highly.

thlt

Should aha

any sivn

call, I

would

h.r for opcnlaas that

brand‘n ha: ouporlnncn.
1976,

Hy

has: personal rcsaréu

b. grutcful for
any

ﬁnd

any udvtec you

utiliaa hat taltnt. or

but: wiuhcs for a hnnlchy
Sinnarnly yours.

F1nk,u.b.
Prof-Ito: of Psychiatry

Max

uF/cia

P.3.-~I havc tout ch.

'

III! lotto: to Jo. react.

�</text>
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27 December 1973

Joseph Thane, H.D.
Research Division

Boocgp

State Hoepitol
Street

S91 Horton

Bolton, Massachuoette 02126
Dear Joe:

I on writing to recommend Mien Carolyn Poinier, who is
interested in continuing her education in Boston
end any oall
you for advice as to a position en a research eeeiotent. 8h.
gredueted Colby College with excellent grades
June. 1972,
and he. boon with me these pee: 18 months. Sheinhas
pated in the work of this laboretoty folly, includingparticirecord~
in; of BIG. proceooins of EEG vain; the Inn 1800, otatiotioel
analyse: and beheviotel oveluetione luring human experimentsall of those in male volunteers.
-

She

is en attractive

girl with enthusiasm
that io'unmntched by any of the leuy young
people who have
worked for on. She is reliable end deyendable. and
I recon—
oend her highly.
Should ohe

cell, I

end ohaxuing

would be

give her for openings the:
broaden her experience.
may

1974.

M3

beet pereonel regard:

grateful for any advice you
utilize he: colonte or

may

end

best wieheo for a healthy
Sinoorely yours,
Fink. H.D.
Professor of Psychiatry
Hex

MF/oie

P.S.-I

hove

sent the

some

letter to Ernie

Bertmenn.

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                    <text>vm—nwn—r—w«-.—WF—g-

-=—r-.yi..-.r

W—w-

-4

7333~86788
27 Daaambc: 1973

Rabat Mbyur. H.D.
Dcparcnnnt of Psyahinery
Harvard Modical Schoal
Hebtan Hoapital
115

Hill Surge:

Bolnount. Misaaahulcttu 02178

bunt Hagar:

I an writing to raaalncud H11: Cnxolyn Poinicr. aha 1;
internstod 1n aontiunins ht: odueation in Boston ﬁnd any 5:11
you for :dvicc an to a position as h r'seareh an:1¢:ant.. 8h.
graduatad Colby €011.30 with cancllunt stadua in Jana. 1972.
and has bonn with an than. punt-18 nontha. She ha: particin
patad 1n eh: wnrk of this laborgtory fully, including rocord«
in; at Inc. proeatainx of 880 using aha 13H 1300. lentiutical

analyses and bchavtornl «vgluatioas during hunnn caparincntn-~
all of chnuu 1n uni. voluntcctt.

is an acera¢etvu and charming 31:1 with enthuatasn
unmatchud by say of aha win: young poopln who havn
worknd to: an. Ska in rnltabla and dcpondnbln, and I racon8h:

tht: is

nlad but highly.
Should aha

racy

enll, I

would

b: grntatul for any ndviuu you
may utiliua hat talent: or

31v. ha: fat opcninsl that

brandcn hut unpariaaco.
1976,

my

bus: par-anal rugnrds and bolt vinhca for a hoalthy

Sinatraly yours,
Ha: Fink, H.D.

Prefualor of Payahintry

Erlets

�</text>
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                    <text>7383*84ﬁ83
27 Docaibor 1973

60““

“muky

g,

H! .D 0

Boston Univoroity
80

East Concord Seton:

Boston, Mhooachuoott- 02215

Boar Conan:

I

writing to tooonnond H111 Coxolyo Poinior, who in
intorostod in continuing ho: oduoatiou in Boston and may call
you for advioo no to a position an o roloorch nooiocaot. 8h:
sroduotod Colby Callus. with «aeolian: groans in Juno, 1972,
on

and has booo‘with no
pat-d in tho work of

that. post

13 months.

Sho has oarcioi—

this luboratory folly. inoluding recordw

precaution of REG using the IEM 1800. statistical
onalyooo and bohtviorol «valuation: during human oxporinontow—
all of that. in halo voluotooto.

ins of

EEG,

She is on ottroctivo and char-ins girl with onthuoioln
unmatchod by any of tho only young pooplo who have
workod for no. 8h. in rolioblo and dopoodnhlo, and I racon—
oaod ho: highly.

that is

Should oh: call, I would ho stototul for any advico you
xiv. hot for opunioso {but any utiliso hor tnlonto or
hroodon ho: oxporionco. I would also ho grotoful if you would

may

bring thin
My

1974,

lotto: to Allan

Miroky'o actuation no "I11.

boot poroonal contra: and boot withoo for a hoalthy
Sioooroly yours.
Mn:

Pink,

M.D.

Profoooor of Poyohiotry

uF/oio

�</text>
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                    <text>73AP-850AP

28 December 1973

Donald F. Klein, M.D.

Director (Evaluation)

Department of Paychintry

Hillside Hospital
P. O. Box 38

Glen Coke, New York 11004

Dear Donald:
Your judgment about Lehman Corporation stock is correct.
price discount: the net asset value by at least
202, and 1t is impractical to sell the shares at this time.

The market
When

the discussion started in the spring 1:

been on appropriate time to make some changes.
present, I believe we ought to do nothing.
my

best regards

And

may have
For the

best wishes for a healthy
Sincerely yours,
Max

MF/cis

Fink.

M.D.

1974,

�</text>
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                    <text>73SBn848SB
28 Decombcr 1973

Craig Burroll, M.D.
Vice President-~Roooarch

Sandoo Pharmaceuticals
Hanover, New Jersey 07936

Dear Craig:

Sitting in Loo'e choir loot week. he told no of the many
interesting things thet you seem to be doing. It must be a far
cry from clinical drug evaluations. Yesterday, in reading a
list of new publications. I found e citation for The NonrModicel
Use of Drogg; Contoqggrory Intervention Isoucg. The citation

dooe not have an address for the publisher, and I would be grote~
ful if you could have your secretary send on tho publisher's eddrooo end the price so that we can obtain e copy for our librery.

In October I had tho opportunity to vieit Sendoz in Basel
and presented a colloquium on my favorite eubjoct, the CNS of~
facts of psychoactive drugs. I was delighted to find their labo~

tatorios fully equipped to carry out computer processing of

proelion.
My

mwa-VWW'WTW25

regards and boot wishes for a healthy 1974,
Sincerely yours,
Max

Fink,

M.D.

Profoueor of Psychiatry

-

2x".'1w.11

EEGe.

Both Dr. Roubicok and his co~wotkor, Ht. Metejek, have done a
uplandid job in programming. I hope that those mothodo for predicting psychoactive drug effocte will find coco practical ox~

MF/cie

�</text>
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                    <text>July 9.
Dr. Joan.

1973

Villiona

Dopnrtaant of Political Satanic
BUN! ot Stony Brook
Door Dr.

Williams.

wo undorstond that the Department
ho: a sorter. which
in ovnildblo for the use or other Deportnonta
from tins to tins. Vb
occasionally need the latter for 1~2 hour: to rogrouy data from
ongoing otudioo.

Mr. Ira Snaipor is responsible for the work
under
my’dirootion, and I would be grateful {Or any nouiutonoo
or
potato-ion
you may he able to give him. Should it to possible to make
a key available
for his use, V. will oooopt tho rooponnibtlity.
Mhny

thonka.
Sincerely yours.
“jZé;Lk{;2;&amp;dL

Fink. M.D.
Professor of Psychiatry
Mo:

�</text>
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              <elementText elementTextId="57462">
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                    <text>My 9.1973
ﬂeece Pierce, NJ).
Ortho Reeeereh

12mm.
Deer

New

mam“

Jereey 08689

We.
writ» that

or Beptenber.

of Dr.
um
women”

Enclosed is 0. copy of the emicmlm
he bee received the edditionel

mm.
ebm 8063 end the: the and: in meaning well.
Xe

He

I had intended to View him during the eecond week
writes. hover», thet he V111 be in Bpein et ﬂat

tine-airwavetocmgewumm, ”melee-poem trip.
We

heve begun work on the protocol for en

eleohoneaetndy.endumu1heveeuethingtam,1v1n
eeadttontoyon.

what ram.
sincerely y
Hex

we ,

Pink. NJ).

�</text>
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              <elementText elementTextId="57452">
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                    <text>My 16.
Janna
VA

Klett,

1973

Ph.D.

Eerry Point, Maryland
Dan: Jun,

It

van a pleasure to vnwk with you and Sun in Dcnvnr.
study sauna well~1n~hand. and the investlgntorl lean enthusiastin and cooperative.
The

is a reprint of the study of laboratnry tests
associates and I carried out in Missouri as part Of tho
ECDEU program. It suggests that concurrent inborntory
tests in
taxable controls provide the prlncipnl comparison for evaluating
whcthnr a new drug alters laboratory tests: the rcnaons include
variations in laboratory standards, tnahnicinns, tin: of ynur
Encleaed

which my

Ima

season, etc.

Holden went on to dcacrfbe significant changtl in
tutti. when comptrod to concurrnnt controls. with
receiving thioridnsinn and/or chlordianapoxido (Chadd. Pbyoh.

lnbarumory

pittants
J. 14:299~301. 1959); and in unothor study. in patient:
rnceiving hulapnridol (Biol. Pnyeh.3: 173~182). (I helluva there
.3 also a more rocont rcport. bun I do not has.
it in.uy lib.)
I would luggnst, thnrctorc. that tbs boat control will
be concurrenﬁ Iluplal in thn patient: ronclving mathndonn, ﬁnd nhnt
Anson.

~nll canpnrisonn be botvuon the sroupn, rcthdr than nautnnt taxﬁbook
or proncntdblinhod lnborntory standards.
One

indiaatod than

other point: the printout of the urinounnnlynctn. nrino. If the tent

no subject hnd conning in
was not coup. in would b. butter to mark

rnnhcr than

this :- "E.D." or ”—-".

0.0-- rooqrvina thls notation for
I look fnrvnrd to grouting

n ronl 'nngntivu’.

you ’nmunsat'

in August.

Sinoarnly yours.
Fink. M.n.
Professor at Paynhintry

Mix

�</text>
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                    <text>July 17.

1973

Costa Stefunil, 14.1).
of Pays-hum
"‘
mitten Kospital

Went

Athena, Graeme
Dear

Cantu,

halo-ad are three chock: following your request:
l1366 0.3. for salaries
$ 11,200.00
(1390)
#36? 0.8. Ianoct feet
~

,

11368

0.8.

mph”
oops-mutton
I

(600)
to 6/30

1,990.00
2,500.00

Lino: directly the sun at
81.690. representing the salary dune him; and sent Costco Kira:
“minimum his animating um! laboratory expenses to
$1.636.
ISO 73.
.

have ulna paid Dr.

mm

mm
unspent to Donahu- 31, 1973. You will note ms I
ruin
have What some of your requests to arbitrary catngorios, to
as can of theandcontrast allocations. Plan new that m categoricall the
ﬂuiblo.
any cam” (mm
m
m availabl- in to
which an
the mount:
tan]. and Marianna»m
I m melanin; an

“1,380

whiz):

indium: that

”maid

wanted) .

m.mm1ammwd.nommtmmunw
m1 three am km in stony Brook; ha ha
12:1!“ka
“mist“ to
rudmduu tho autumn mm, m is nova-aiming

mm
Warnsm.mwnmmmnthnandofthismk.

mum. I have mum 300
mm.
mm
Linton umwmzmuscau;
Ivinuknr.
”not.
Ivtutry
to bring
the and at August.

an.
mm. but cannot obtain a 1.9.1 use” Home
“port ecu-tiring“ ﬂat I
a: minute.
A:

I indium

mam: from
undue
cinc- the

on

a»

1% 5%

and

:hould

I

but

Mr

mum

W

31". Dr. muo- thc
to th- publication prob)...

m M.

v1.11

W "was.

Binomlr

mu.

m nut. ”-90

“emu.

�</text>
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                    <text>Jul: 13.

1973

33!:

8569

Elmer Gardner; M.D.

Diviaion or Raurophurnnoology

FDA

_Bo¢kr£11c. Mhrylund 20852
*

13D

Dear Dr. Gardner,

I wish to amend the IHD for the study or 01-63 hr an.
unclestd protocol submitted by'Dr. ﬁbbn Kiltin of thn VIK~ New Orltlnﬂ.
The Gusset: and procedures of this protocol are consistent vith our
ydor submissions; the study extending the examinaticn of OI~63 in
new population.

:

Apprbpriate safeguaras for the protection of
subjects are included in the protocol.
,

humnn

Sincerely yourl.

‘

h F”. of
Profousor

“the.

PlguhiuSry

�</text>
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                    <text>W. H, rmw»"‘:I—W“

My 19.

1973

Bhertbeth Mendel
Copy Editor

Me

‘

AMA

Illinois

Chinese,

Deer Me. Handel.

‘holoeod is our edited tmeoripo of the lumethedyl
We ere pleased to accept most or the.
chenaee.
end hove mode e row edditiona (mined in red).
‘

.

report,

Baa-67141: .

'

'

'

issue is of significance. We heme need lama
elohe-aoetylmthedol hydroohlorido in this otudy. I note that in
ember or places, you have
to 'leemethedyl
metete'. It the ‘ecetete' is meant an a. generic port of the
then the empriate tom Would be ”'lovomothod‘yl mote“ ‘hydroehloride' .
If, so I Inspect. the 'aceteto' refers to tho eelt, then the appropriate
ie 'levouethedyl Ivdroohloride' . I have enema the lotto:- in
editing the typeoorip’t.
'

One

edited-1W1

m,

in

.

In support. of this View, I would like to Intuit lone
deoe ream-ding our compound; es veil a". e copy or our 1973 eu'boieeion.
M: thet. time the editors also mended the
to 'levomohedyl
metote' . We were not alert enough to catchtmecript
After goblioetion.
this.
we noted that the editors bod added two names to the end or the
indicating the levonethedyl eoetete 1e Methefrommet-hedode. In ertiolo.
oheokipg
11th the mocha-er. Merck I found that neither
end‘
is
.
theirs;
one
i a checking with the
indie» . I found mo neither

Mention
hove my releteon to levouethedyl hydrochloride.
mm“. nor Mhetroue
-

8w

I eleo note thet in en eerlier ertiole by Jetre 5
21648, pplBOBff) than: the confusion of tens ie eleo unresolved.
Perhepe . the g; form
be celled 'uthedyl eeetete' while the l. for:
celled levonethedyl. 'l‘hie m eteted
in elletter to no by mother,
(JANA:

JANA

copy

egeio. end

m

editor. Mn. Veiee on hornet-y 29. 1972.

for the opportunity to reed the tneeoript
I look torwerd to its publioetion.
Then): you

'

-

sincerely
Me:

me,

rink. 1m.

Profeeeor or Peyohietry

.

�</text>
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                    <text>my

29. 1973

EEGJenr-nel

Eleevier‘

halterden
Gentienenej
‘

1 have moved my

laboratory to

reqeeetthee the subscription represented
be cexit1n‘ued, but addressed to:
'

a new locat1on,

by the attached

I
lebel
and

.

_

_

‘Dr. Max Fink
HSGuDepertment of Psychiatry
sun! at Stony Brook
.Stony Brook. New Yetk 11790 U. 8.A.

'lhenk you.
’

'

‘-

'
..

-

b
.
&gt;

,

.

.gtmereiyfhun,

nu mg;

VPeoteEsqr

m
of Psychiatry
,

.

�</text>
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                    <text>~‘m'ﬂ'mwp-yu «pr-mung,

‘

August 22. 1973

J. Bruinvuls. 2h.D.

'

Asainttnt Editcr

Eurcvaan Jouruhl of'Ehnrnnaology
Utracht. Netherlands
Dear Dr. Bruinvola.

rung:

.

I.h¢w¢ ro-tnad tbs manuscript by Faingeld and Entry with
plansura, and bellow: that it should be published.-Th¢y have nnlwnrcd
almost all at :hg erieicigna thut I‘rﬁ prcscntﬁd by ﬂycalf and the
other raviawur. except the an. of thu spectral ratio. This as. is
eontrovoruial. but that: prgocntation of chn data is uuah that the
ratio probably rcfldcts the ngeurnl axptriunce as wall as any echo:
Innings.
.

_

I nn-rcturning tht manuscript. I rcgrct the daisy in

nnnwnrins, but.thil was occasiouod in part by the article having
bean scat to my torn-r 14420:: in ﬂaw York City, For your records.
91.... not. chn.addtpsa Ibavn for tater. aaununieationl.
‘33 best rogsrda to Dr. dc Visa.

Slncaroly ycurs.

Max.ttnk,

M.D.

trofnssor of Psychiatry

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                    <text>wv-W “Wu—n—

a

'uuvanwi
“7",”

_

Angus: 22. 1973

“mt:

SW11}... M.”Acttns Dirnctor
Div. Haurophnrlncological'Dru; Produces
lurcuu of Ernst. 13A
Ractvtllu. naryland 20852
'

'

D..r ”to

3W1...

'

Ra: IRE

9691

In rcupons- to your 1act¢r of July 2. 1's: nacloaiug a
ruply prtparod by aha liberatoty scientiucn at H.V. Orssnoa aha
havn boon rcsponnibld for ch. basic studio. at the eoapound,
GB~94 (Hiunnqria). I'baliuva that: taply 13 responsivu, and
ask that this b. and: a.nattix gt record for this projcec.
Thain you for your eoopcrac1cn.

Sincgttly yearn,

m: Fink. my.
Professor cf Psychiatry
.

Encc

3

Lt!

EVE

8*14“73_

�</text>
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                    <text>1-.

'

y...

»-

svaC‘ﬁ‘

.

-_

mum-n. »_v-.v.mzuv--

is
W
'1“ MI. 3"
n13.1314-

g

V

":5

_,

August 22. 1973

K1113. Hons

hospital

YO“

Durban.
I hm sosd tho outliuo of tho smootod pron-so for tho
sad not for so oxcollont formation.
sposkoto. you hm thou-mod tho
s
stroy

.

sud wish to mootulsto you
ms hosting, such
£o'tuidsblo
of

ly dmlopiua
lootwot sad as to

Roch

costs up with

«nothing of oquolly tins qus‘lity.

to spooitios. 8.1m mom is prosontin: on tho
dismount to: Labor-sky sud Prod: should ho Lovitt. I would
to mass his “potion“ so ho dooos
and»: ho
soproprists, olthough ho could to on woolloot oltsmts choimu for tho
As

second dsy. tho
concur thot Boy

mom

first action.

You osy out to couoidst moths Shogsos so o discussont of tho
hoh-stiot thotsuy nation 1! Joins Frank is not sscoudsd. masons hos so
sctivs iotot‘sot in this thstspy sud hos misusd tho dsto wtonsiuoly.
'

'

sddooss should
tho Koch sword

tho troditiou of tho

Foch «std sud tho Possidsotisl
sud hsvius one ooch dsy is sstisfsctory. with
also no tho
sword, sud this osy «quits o too oars oinutso.

to stintsiuod,

will

V

rum

For moons of history, it would ho us'oful if so could inoludo
Exits Payton. ”shops so s couchsirosu o! coo of tho sossions.

I

would oucoursxo you

to {cmlsto this prom-so so

occsptsd, soot-sins tho othot woos oi tho Council moo. sud you writs to
tho invitod portioipsnts tor so abstract. Should thoso ho svsilshlo by was
sod of
or only Octobor. to soy yo: ho shlo to host tho usual
rush for tho dosdlino of tho Journal.

not“:

My

thanks for on

woollsnt job.

diatom, you-rs.
Koo

to.

30 Colo
R

Spits“

Fink.

24.1).

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                    <text>at.
V.

norm

Joooph

3.

31mm ‘ 3m; 1m.

“amt“.

,

20005

lingo.

Boar Hr; Exit-too,

'

Known“ in o “ﬁlo of «amt-t. Mattias tho ordor
at 11:: of participants, and the eonﬁorooot connotaood ockmlodmott. for inclusion in tho amino on tho Pr"
By mi,
thoold hut method two photon“
inoloddm till. ﬁo oditod dusts cool“ of tho thwart of tho

of

“mum;

'

.

,

-,_.‘

.

m

“1%

mm

ﬁt

that“ for

your

womanhood potion“.

.

‘

shall M on: of than :20qu ohm stptemhor 14, out
noold' opprtoioto
(no you about hot tho to to tho out “to:
to tho pinata: of this vol“.
W.

.

'

’

Sinaxoly you“.

w

Fink. zoo...
”Profane: of Put-hum

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                    <text>Ausﬁﬂt 23. 1973

am: a; madman.

RIIIIth

II.

eon-u1tanc.=saon12
Inn-mum»; me; 20:00

DIIr Dr; Mindiluon,

I

w1th IIIh inacrcat and Uith
IIII that “353; stratus:VIII
doeunantad
AI

to

you
III your IIIII1IIII II I
rIpoII.
requIIIId. I thI rIId thI SectiIn 111 c IIfoIlly. and III IIIII11II
If thI IIIIIIII 1I EhI tIporc.
command

you

IIII

III IIdI If IIIiII of III vIIiIuI
tbs Iffccta 1n thI

drucI usually IbuIId 11II 1n
UI1I5 the nIchIII of

IontrIl IIIVIII IyIIII.
IlIctzIphyI1I1Isy, IIIIIIIII IIVIIIIIIII hII been Ionitarld for IIIy
It thI drugs at IbuII pItIntinl. quld IIphII1II the 3tIIeIr
IIIII1II11II by thI Ilaccrovhya1ologinta Ind thI1r nIthoII I1ﬁh the
IIIIIIIII1I1I III IhI1: IIehIdI II ebb IBIIy It the £I110I1ng IIIII1III:

I

'

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I1nor trIIqu1111xItI;

If dIIIleIIIc

of Iolnranee :9 1h. IIdIt1VII Ind

".. thI intIrIctinn If thIII IIIIIIIII with agent: known to
contral nIuthIIIrI II1III1VI1y, II attempt I I11r1£1catton
d1f£IrIIt
IltIr
If thI IIIIIhIIIrIl IhIagII that IIIIanny IIlIrIIIe dIvIlopnInt; and.
'

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Ind
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‘

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A IIIIId
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IIh1¢h IltIr hrI1n tunetiun for IxtInIId pcr1odn. This dIvIIIIIIIt hII
,f Ilzandy bIII IIIIIpl1IhId for EhI Int1pIthot1I drugs; III boan jo1IId

"Ju

If I laaszIcina II1I16 Intngon1lt; and should be
thI dIvulopIInI of I Ions III1I; IIIIId1IIIp1II (tI
IlIIhol Inbatituta).

1n ehI dcvhlopIInt

Canburlﬁcd for

bI IIId

II II

IIIItt IInI1III,

but III. III IIII to I1Ibctaca, ehI IIId
for I morn int-III effort It III ddvnlIyIIIc of II Ilcdhol IItIson1It1n pIrc to aid II: undIrItInd1n3 If alcoholinu III IIIIIII deInIInII
thIIulh III tIIt1n¢ It ctIItIIn: IIdIlI I1I11Ir to ehIII undo: Ituéy
1n Ip1I1d IIIIIIIIII II1I¢ aha IIII1I1I IIrIIt1c IIIIsIn1ItI.,
'

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,

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J‘&amp;

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MCJJO‘.

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«nut-oou-nib‘umt 22,

1973 oncdovtbaonosétqpﬂ 2.

.
11-:

wwwwxmmrv'"

w
-._

nm

,
my

worry-my

Stratggzlutntienn, but doc: an: anyhaatsa suffieieuuly.
the psycholosic eouponane; of toltrnnnn and dcptndancn dcvtlopncnt. I
ht?! bacon. tart-sand that tho davulnpmant at talgranac no tha'upiatea
ptaeiods at varying raton for dittortnt anpnatn at bdhtvior- being unit
lonaqr
rapid for tho na1f~rupnrt ayntamn at wand and attitude; slightly and
for alaccraphystalogte maasuxcl 5! the ass :94 task purfornaace;
tuck informatiau 1‘
Ian‘s: still far the nutcnoaic CH8 offsets; Whilcstadium
of than.
ariildblc ta: ta. barbituxttnt and the apintas,
and
s'phecauiaal
pattnrnn with the bonsodiauapinaa. cananbil. ulenhol,
warrantn'furzhar study. partiaularly Itnca Eh: methods a! nonsurensnt
The

of bdhaviar.zcns yhyaiolagy. and tank yarfarnanac hava improved aonr
aidorably. The goal at that. atuéicg could bu to deiina tn. pattern
a! telenanad development, rolutionn to dapandanao. and tha variations
among Iﬂbjlﬁtl. :9 salad: uh: tayortsnt quastionn of the charaacartttién
of chi ‘daptnﬁence~liabil£ patron.

aaall point with regard to caution III 6. Tha pauitian
with regard to ¢anndb1u is strainnd and unaonvincing. I unndcr shy eh.
cannsbia u3¢, vhcn
repert pays no little attention tn the uvidcues that
Tha
cvidanne tron ths
Inﬂ
urn.
_ptolana§d. inducas tolatanat in animals
inhaled
by Janaiinns
Nina contract ﬁtudicu of high dons: at eannabts
One

and Grunts

Arkans, subject: ranpond to 150 we ran»
new York valuntnexs snaking 10*15 mg.)

is impressive (in

acltuua equivalent lika

for tha opporéunity tn rand Ind raspond no this
doeunhnta'Ijrograt that I rncaivad 1: tea late to nae: the date an:
in thd 10tt¢r- but ptrhaps thee. thought: any ya: prov: helpful.

I thank

my

you

"

best rcsardn.
sincerely years.

I!“ “ah,

MIDI-

Ytafesucr of riydhi‘tty

.y—t-s-w‘rvr;

7
‘

~

:vx-n-wu

4-4 WWAA‘I—r-t'lrw-‘v'rrv—

�</text>
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                    <text>September 13, 1973
George O’Brien, M.D., Ph.D.
Departmant of Clinical Research
Abbott Labcratortee
North Chicago, Illinois 60064
Dear George,

It was a pleasure to speak with you yesterday, ana I am
interested in the dartvativea of cannabis. I look forward to maeting
with you an your return from Paris.
Enclosed is a copy of the guidelines for the evaluation
of anti—epileptic drugs. This was distributed in the registration

packet to

all

the registrants at tha Intarnational

in Haraeille early this
my

month.

EEG

wanting:

best regards.
Sincerely yours,

2'“ Pink.

HOD.

Professor of Psychiatry

�</text>
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                    <text>September 14, 1973
Warner K. Herrmann, M.D.

Scharing

AG

Poatfach 65 03
1 Berlin 65

,

ll

Dear Dr. Herrmann.

for sending the interesting article on
tha origin of nattcr. I have sent it on to my son's: Stanford Univerulty
and he thould write to you dircctly.
Thank you very much

t:

I would be pleased to mac: with you
your convenience. I
60 not know when you at. returning to tha States. but should.yeu travel

via

York. please stop for a day. I shall be in my laboratory
October 24 whoa I am planning tnother trip to Europa. and

Naw

until
will bu

away

for three utaks.

Ho have had an attlvn sauna: at the beach. with mnny visitors
sud many new experiencns for my family. It has been a good experience.
Dr. Itll and his family span: a week.w1th us and that was a moat anjaydble

time.

.

.

Please cone and

visit

noon.

Sinceraly yours.

Fink, M.B.
Professor of Psychiatry

Max

ut/

�</text>
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                    <text>Septembar 20, 1973

Ralph

W.

Ridhtor.

M.D.

Harlem Hospital Cantor
135 Stront &amp; Lonox Avonua
Haw York City 10037
Dear Ralph.

to have an opportunity to ravine the
chaptor on narcotio antagonist: for your volume, as there havo been
some additional data. particularly with regard to nnltroxono, which

I

was plunged

should have~been included.

'

'

Enclosod 18.1 rovidad draft of the roport for your
will be accopcdble.
consideration. I trust

it

my

boat regards.
Sincerely yours.
4L£f

.vW
Max Pink, 24.13.
Professor of Psychiatry
u. v

�</text>
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                    <text>Septeabar 20, 1973
Dear Turan,

I received capiea of your letters of invitation to
and to Dr. Horrnana. inviting than ta participate
Polvan
Profossor
ACNP
session on trannnultural a:pactn- studios of new drugs
in the
tho
outside
v.3.
'

care to inwiea Hank van Eiazan of Organon
to present thair study program 1 I hive invited him to attend the
A53? as my guest and perhaps he could dascribe the 63*94 or the
61‘63 8 tax-ea
Would you
o

my

best regards.
Sincerely yours,

Mix

Fink,

M.D.

�</text>
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                    <text>September 20,1973

wnlter Essynn Ph.D., M.D.
Deportment of Psychology
Queens College of CUﬂY
Flushing, ﬂew York 11367
Dear Walt,

I am pleased to accept tho appointment as consulting
editor for the series, Recent Developments in PsychapharmaooZagy.
You ask for suggestions for the initial volume, and
while I do not yet know the range of topics already committed. I
would suggest you consider a chapter on tne application of

quantitative EEG to the classification, identification and
dose—response measurement of new and presumed psychoactive drugs.
This method has had some interesting applications recently, and
deserves

more

exposure.

It the idea is

I coulo send

or some inteoost,

you a

copy of recent publications and an outline of a possible contribution.

Again,

my

thanks for the

invitation.
Sincerely yours,
I

Max

V

Fink,M.D.

Professor of Psychiatry

�</text>
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                    <text>September 29, 1973

Stash Press
638 Pleasant Street

Beloit, Wisconsin

53511

Gentlemen:

Kindly send us one copy of the volume:
"Msnsgement of Adolescent Drug Unee". Enclosed

is our check for $5.00.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Mex

�</text>
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                    <text>7—w-

-

“mu-WW.“

September 29, 1973

x—

w
,

v-w-qnw-w';

«v,

Prof. Dr. P. Kielhola
Psychiatrische Uhiversitatsklinik
Basel, Switzerland
Dear Prof. Kielhols,

~‘w~r.'mm-wr

""‘v-rn

,“.1

grateful for your kind invitation to come to your clinic
during my {Orthcoming trip to Basle. I would be pleased to visit and
to discuss the ongoing research into the CNS effects of psychoactive
drugs.
I

am

I an visiting Beale as a guest of Dr. Jiri Roubicek, and old
friend and co-vorker. I do not have a schedule for my visit, other than
I plan to arrive in Beale from Zurich on Wednesday morning, October 2h;
and to leave for Amsterdam on Friday morning on the same flight which

you have scheduled

at 10:30.

would be grateful if you could call Dr. Roubicek. I am
confident that any arrangements that are suitable to both of you will

I

be acceptable to me.

I look furvard to seeing

personal regards.

you

later this

month.

My

best

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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29 September 1973

Jiri

Roubicek
Experimental Therapeutics Department
Sanloz Ltd.
Dr.

Basie, Switzerland
Dear

Jiri,

It was a great pleasure to be able to attend so many of the
meetings in Marseille with you, particularly the many discussions which
fOllowid the presentations in our common session. As a chairman, I
very much appreciated not only the content and the spirit of your
remarks, but your willingness to lead the discussion. I found the
meetings most helpful and interesting, and I look forward to continue
the discussions in your laboratories.
I received the enclosed letter from Professor Kielholz. I
at the GIMP committee meetings in Beerse before Marseille, and
in exchanging pleasantries indicated that I would be visiting Basle
in October. I am also enclosing my reply-- trusting that you.can make

met him

arrangements which are diplomatic and acceptable to you.

family has discussed the forthcoming trip often. Neither
free to come with me, but Linda, my youngest
me. Because I wanted to allow her some freecome
with
will
daughter
dom, I am also bringing along my nephew, and so I will have two youngsters with me. I would be grateful if you would arrange fOr two rooms
for the two nights. In checking my travel arrangements, I am scheduled
to leave for Amsterdam Friday morning at 10:30.
My

Martha nor Rachel are

regards.

I look forward to visiting with

you and Marcia.

My

best

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

amen v

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                    <text>7353—662

Key

Kety.
SW
Jeane: new,

1.

1973

14.1).
1711.1).

Min Ken, NJ).

Deer Seymour. Jim, and Martin,

I hue received an «gushed plane cell from Tom
William in response te w letter announcing the full
ennui-110:1 of the articles from the meeting to the
publisher. He enquired u tn whether indeed he "had
been and from the editors". Hot knowing how to respond
mediately. I indieeted that I ma consult you.
I do not recell the compact which Tom is referring
that in editing this velm we did not
to. I do

m

that, in truth. his pertinipetian was
limited to representing the Clinical Research Breach
at the program eeuim.
«1.1 on him end

If there

in e

mi: which I

may be

neglecting,

grateful for e ruinder free any of you. In
the ebeenee of each In reminder I would be inclined to
learn the
u they ere. I an grateful for

I

would be

m

mwnte

advice.

sincerely yours.

Fink, HJ}.
Profeeeor of Psychiatry
Mu:

16/13

�</text>
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                    <text>7383-662

William Guy. Ph.D..
ECDEU Data Analyses,

Bioaotrio Laboratory.
11501 Huff Court.

Konsington.

MR.

20795.

Door 3111,

Enclosed is an salted report of ECDEU unit 006.
also pleased to enclose tour RPﬂ’a of ongoing
studies.

I

am

Insofar as

my

unit is

no longer

at tho

Rev York

Meaionl College, but now fully installed at Stony Brook,
I would be pleased if you would continue to use the
designation of the unit as 066, noting that the new
address is that at Stony Brook.

for the firot output on the ECDEU data
and I agent some time raiding
Despite the variety of populations and the large
it.
numbers of subject., many of the cells are quite small.
Tho project is indeed a many your effort.

bank.

Thank Ron

It is interesting.

Sincerely yours,

Fink, M.D.
Profosaor of Pnyuhiotry
Max

ur/ia

Enos.

�</text>
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                    <text>7&amp;I-884
ME?

Kr. Lawrence Erlbaum,
Vieo—Prosidont,
V. K. Winston &amp; Sons,
1511

street,

3. 1973

Inc..

N.W..
washington, D.C. 20005.
K

Dear my. Erlbaum,

Enclosed are three sets or dooumonts for tho new
volume.
#20.

Clinical Progroas in convulsive

Therapy

is report

.l

w-uv’.

1—.

-r-—Ann~w

umqu,’uw

w—uv—p—mv-z’arr

W‘wrnww

1
v'r

-.

rrrrp-v'

a

wwwuvv—wa

-.

vmmmm-w

wrmm—aq-mx.w—mmupmww

1-

my”

.‘mn'l‘rgsv

:u

Irv‘cﬂymirﬂ"!

After submittﬁig, the report by manual: and William,

in relation to the summaries written by Katy and
myself, I made some changes in this summary, sent tham
to MoGaugh and Villinmn. and have gust roceivod their
opproval for the changes. I: you will compare the draft
in your hands and this draft, you will find that the
changes are essentially in the first two pages, and
thereattor they are minor.
and

1 am also submitting a coyy of #15, the article
by Koran: on multiple BOT. I am enclosing two copies:
one as revised by the author, so that you can see where
tho small ohangiu wore made; and a rotypod copy which may
not. it easier for your editor. These changoa wore
requnotod by mo, insofar as on important report concerning
multiple EDT appeared in tho Fobrunry, 1973 issua of the
Anoricon Journal of ?sychiatry.
Only looking at this moment is an introduction by
Dr. Ritz. I visited him in Wishington yesterday, and
he agreed to send it to no boforo Friday, indicating that
the delay was in port occasioned by the necessity to check
with sons of his superiors.
Ono

answer,

the

1973

This

tachnioal problem which I did not know how to
way to refer to other articles in

is the proper

I have worked thaw as
and "this volume” in the citations.
arbitrary, and I would ask your editor to not a

noon volumo.

in the text,

is

more acouptdble

For conveniouoo.

style.

�w.

Immense Erl'bmm

this

We

are

now 99$ up

~2~

ta date.

month. or early Jung,

than!» hm

when

mdvould like

May

I

3. 1973

Except for one weak

V111 ha

in

Rumpus.

aimerely yours,

Ma: 11:31:, Md).

Executive Director
Emu.

later

tomt v1thyou, 01-er

um edited drafts at year earliest conveniences.

ear/1.3

I

�</text>
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                    <text>7383 t 665%:

my ,
14

1973

Virgil Pinon, K.D.
Alan carparution

950 ?usn Mill Road
Pale Alta, Culiturnia 9h30h
ROI!

Virgil.

EncIOch is a slightly odiﬁad varnion 0: tbs applicatiana
aha tun royorha for ynur tilts. Bus is the :uunnry of our nalomnno
punncte «spurious. (thin in unsublishcd); thp uoeond is the summary
I wrote tbr the Mhridunna Commission tad in its reference: it contiinn
tbs latcst I could find an at tun months ago. I have ehaekad n tar
a! ﬁhn eitaiions run urn lauking.

I

um

ulna enclosing a eopy of

my

curriculum viii». fur

to dbstract in the upproyristc pines in tho application. Shauld
you'wish. I Vania be pleascd to be listed as a consultant to the
proaact. Shaula you yisn to ham» pariodie meetings in an. planning
of tbs variant phases of the yrodeot, uv'yarticipnxion eeuld bu
liltod in the expanse budget at truvel plus eonsultation tee.
in ninil:r vunturcs w! hnvu rneoivod $200 to QBOO/day or same
fltt figuro fbr the year. In this proyousl, listing 3 consultant
a&amp; $1200 to $1600 the first year would yrdbdbly pass without cougluint.
I trust thase note: are uaotul. Good luck in the
ybu

product.

Bineeroly yours,
Max

Fink.

M.D.

Praia-nor or Puywhintry

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                    <text>rw‘

an»

‘I'm"

Ir
-

n...

q-m-

—.

.»

up.

».

wmwv—q v-vsanw-w rum

m1’4m

"W_...,,

av" .

«n-u‘

,

-.

p

.
.. .w

avg—P? .. .,

.

7

YEW.) mm~

m.

7388:0993
May

Burton Angrist,

M.D.

York University College
550 First Avenus
New York City

New

5. 1973

of Medicine

Dear Burt.

I

have rs~rosd your
interesting. I an vriting

report on CLllo,393 and find
to raids two suggestions.

it

most

In your experimsnts, you seensd to allow the sessions to
proceed for many hours; and in the discussion you note that the
was this
effects of this compound could be blocked by noloxone.
2
The
implication
effect tested in man 2 sad. if so, did it block
wonder
why.
and
I
not
was
tested,
was that it
The similsrity of this compound to storphine is indeed
striking. Tvo years ago. when I became interested in very potent

use.
opiates, I obtained a supply of storphine, which I did not
nsture,‘
similar
of
a
undertake
sons
trials
to
I would have no hesitation in supplying s fsv mg for your use.
My thanks for letting me rend this interesting rspbrt.

Should you wish

Sincerely'yours,
Imumm‘mvc’

'I-I-‘W'W-w—awv-w-w

1‘

""Wwvwrw

5"
‘
"~

‘
"'
"

'
“m"

mm:

“ain‘t-u

uwvr

wn-

wr

Ms: Fink, M.D.

Professor of Psychiatry

�</text>
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73832102
May

7. 1973

Professor Heinrich Klﬁver
Culver Hall
University of Chicago
Chicago,

Illinois

Dear Professor Klﬁver,
was most kind of you to send me a reprint of your
introduction to the volume by Schultes and Hofmann. It is a
delightful history, and your essay stimulated me to find the
volume for my pleasure.

It

Since our last vriting, I have devoted my time to the
clinical problems of narcotic antagonists in the deconditioning
of opiate drug-seeking behavior. One compound, cyclazocine, has
been of special interest, because it is a most active antagonist
to heroin, and yet, in its use, stimulates a variety of illusory
sensations. These can be blocked by another antagonist, naloxone,

some interest. unfortunately, most
on clinical problems, on ways
focussed
been
have
of our efforts
and not on the immediate
in
behavior,
to affect a long term change
The study
compounds.
these
psychological events accompanying

and

their interactions are of

has permitted us, however, to explore the acute physiological

effects of heroin and also of different forms of cannabis. It is
important to realize that the drugs which are most commonly used are
shortthose whose effects on the brain are immediate and quite
2~h
minutes;
of
matter
heroin
a
is
of
lived: the desynchronization
short.
cannabis
equally
the hypersynchronisation of
satisfying feeling for a teacher to
realise that his students are productive, and that his ideas of
been of influence, beyond the immediate perception in the
classroom. My congratulations, and my thanks for your kind
.

It

must be a most

remembrance.

HAW“

.m-qu-

Sincerely yours,

w
n.

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>Mty

7,

1973

Harold Mnilullﬂ. M.D.,V1ee—Chnirmnn

Narcotics Addiatinn Control Commisaian
less‘arnaduuy
Nun

thk.

Nan-Ybrk

10033

Baa: Hiﬁbld:

I have Joined tbs iteulty of thc Health Sciences
the
Univaruity of New Ybrk st Stony Brook. Effective
It 1973 State
Roanick ha; teeuptud full responsibility,
Dr.
Richard
Int,
under thy suporviuton of Dr. ﬁltrud M. Fraudmnn. fbr thn scientific
3:9Icta of the contract bctunan tha Narcotics Addiction Central
Commisuian and the Nan Ybrk Medical Callas: {by thy study of narcotic
Intngnntsti and m-rijunnn.

As you miy knnu‘

Cantor

th

At Dr. Pruadmua’l request. I will continue
as long ts 1t 13 mutually antral.

ta assist Dr. Rennick for

For record purpesaa I unuld suggest that yen notify the various offices
that all communicatiaan be diraottd ta Dr. Freedman; axeept for theta
and these ohauld be sent
which would ardtnnrily be d1r¢ctcd ta mu
Raw
B.
Mbdicul
R1ch¢rd
Ybrk
Dr.
Roanick,
to
Callegt. 5 Bart IDan Strict,
Haw Ybrk. New Yank 10029.

..

It

has boon n.9130surc to wank with yau than: many years and I hogs
thnt it will bu poaniblo ta rouontablilh a wanking rulationuhip through
Dr. Yallas at Stony Brnok. my best personal regards.

Sinauvaly,
mfajr’

ccznr. Richard
Irvin B. Schwartz

B. Rulniek

Mix

Pink.

M.D.

�</text>
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                    <text>731: 3.033

W 7.
m. Inwanca

13:le

v.3. Hunter:

a.

Hawks-1:19:31;

1511

K

1973

Sons

Street. m1.

wuhizwbon, 13.8.

20005

Dear Mr. Erlbnum,

Enclosed is the introdmtion to the mime by Martin
Kata. This represents the last. I'm-ml (”went for the volume.
lacking is the list of participants and their affiliatiam. I
have written to all the authors and asked that they sand me.
by return mil, edited titles; mad I have most already in hand.
This submiasion should make possible

a.

better

size of the valume. and the time course of
«that. omtheI will
call you later this week to see where
pumaauon.
we stand.
Sincerely yours,

Mu Fink. Mm.

�</text>
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MR?“

318 Department

T. 1973

of Hedth

Bur-m of ﬂax-cone Control
8% Gentrtl Avenue
Albany. Rev York
Gentlemen:

Enclased is my cheek in the amount of $10.00 for 100
sets of triplicate prescription forms, for preteribing subdue II

drugs.

My BKDD

amber

is

AF

1732103.

Sincerely yours.

'2

Fink, NJ).
Professor of Psychiatry

343x

�</text>
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                    <text>7383:666

May

8.

1973

Jules M‘ssernsn, M.D.

6 South Michigan Avanue
Chicagc. Illinois 60603

Dear

Enclosed is an edited proof of tbs contribution to thc
ncxt volume of Current szghintgia Tharagies. There are a few

g

E

minor corrections. chiefly in the eitaﬁionn.
Thare are two
omissions. however. which I am bringing to your attention.

E

'

3

E
z

g

Jules,

ditttrant

,F\
,

The footnote, assisting thg reader to separate the
forma of long acting methaaels is amitted, and I

has. added

it.

The credits doletcd.uy geknowladgement to my co—
workers, and to the funding agencies which have supported this
vamk. I an incluaing skate with the request that these debts

be anknowledged.

volume.

My

thanks again for inviting

my

participation in this

Sincerely yours,

max Fink, M.D.
Professor of Psynhiatry

�</text>
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.0

..

""77

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,

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M...- ...

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fur" MW!

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9 May 1973

John

J. Belliani. J.

D.

8! State Bureau of Hercotie Control
835 Central Avenue

Albany,
4

New

Dear Mr;

York 12206

Belliaai:

licensee for reeearch in schedule I and II to V drugs, as wall
as an invert certificate for schedule, at my office at 5 East 102 Street
in New York City. I transferred cone or my work to a new location at the
State University of New York at-stony Brook, and since February I have

I hold

BEBE

attempted to Obtain certification here.

for certification at a second address, we
notified belatedly that examination by your office was prerequisite.
reconsted examination by your office and early in April, your representav

After filing requests to

BEDD

wore
we

tive,

Mr. Conaolino examined

application forna

When we

order,

our location and kindly completed the necessary

on April 13, 1973.

enquired of him, on April 26, he indicated that the papers were in
deliver them to the appropriate agency in Albany on

and he would
Monday, April 30.

not hearing from your office, I called him today and was told that lie papers
have been forwarded, and that I should hero patience. In checking further, I
called Mr. Leonard Valeria, his supervisor, who indicated that he indeed
would have to approve the applicatiOn, but that the application had not
reached him as yet, and that I ahonld have patience.
Considering the excellent reputation of your office for efficiency, I am
surprised by this delay and I would be grateful for any assistance you can
give no in obtaining the necessary certificates. Our work has been delayed
many nonths, by our desire to abide by the law.
Many

thanks for your cooperation.

Sincerely yours,
Max

Fink,

M. D.

Professor.of Psychiatry

Manpv

�</text>
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                    <text>10 May 1973

Saynour thy, M. D.
Departnnnt or Puyehin&amp;ry
EhrVnrd Madicnl Babool

Fruit

strict

Button, Hassaahusetts 0212h
Dear Seymour:
In submitting the summaries to Dan Freedman for tbs Archives. I haw:
a$taapt¢d to mnet his publication style and find that many references
of the sun—Irv luck tn. last pngn or the c1tn$ion.

references. ﬁbula it be puuaible
I copy of tha rcﬁyped
check
citaﬁion lists for the complete
or
to
your
start
your
t
rutoronco tad couplets those? I: thay art cant to no, I can so. thnt
tbs corroetcd citations got to Lawrcncc Erlbanm and to Dan Friedman.

I

um

tar

Many

enclosing
number

thanka.
Sincerely your»,

an: Fink.

M.

D.

Professor of Payehiatry

“Viﬂvv

Enclosures

�</text>
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                    <text>»~ur~— m

7353:10hEc

A.»

.

.‘a-ruw,r..We...

..—

(wwylv'w WW... 7,,

,7

..

4

may

Daniel

10, 1973

Freedman, M.D.
University of Chicago
Box 2011
950 East 59th Street
Chicago, Illinois 60637
X.

Dear Den.

Enclosed are three summaries oi the proceedings of the
conference "Psychobiology of Convulsive Therapy", end s short
introduction for your consideration for the Anchivea 06 Genehal
Pbychiatdy. The introduction is scent to give perspective to the

texts

and proper

credit to the

NIMH.

of the submitted papers is scheduled to be
published by v.3. Winston &amp; Sons in the early fall, and will include
these summaries of the Conference. The publishing contract use
negotiated with Mr. Erlbsum with the understanding that concurrent
publication of these sunmsrics would be acceptable.
I hope these reports are acceptable. My best personal
The volume

regards.

Sincerely yours,
an

Fink. M.D.
Professor of Psychiatry
Mex

yv-.—.-,~

Irv-“-

.amxrvx:

,
“I"

Wv'w

.
w.

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mmympw,

“yew-WW

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mf/

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.

,

7383:108FDA

Elmer Gardner, M.D.

Bureau of Drugs-

FDA

Rockville, Maryland

He: Inn 6590

Dear Al,

studies of levomothedyl are continuing, and we
recently submitted documents notifying the FDA that ve have
expanded the studies to my new facilities at the VAﬂoﬂotthport
and SUHY at Stony Brook.
The report: of the initiel studies have also been submitted
to your office; but in the event that these have lot been filed with
this IND, I am submitting copies herewith. The initial report
appeared in JAMA 220:811~813, 1972; end the second is in press in
The

the

same

Journel.

Thank you

for your reninder.
Sincerely yours,
./
r

”44

/

_/,u n.1,»

Fink, M.D.
Professor of Psychiatry

Max

mf/
Enc: Levomethadyl
JAMA, 1972
JAMA,

reports

in press

c

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                    <text>"

'-“'W‘

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«mow-uqup fm-v‘".

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73NY:107

Turon

May

11, 1973

RE:

High Dose Fluphenazine'
IND 5210

M.D.
Itli,Institute

of Psychiatry
Arsenal Street
St. Louis, Missouri 63139

Missouri
5&amp;00

Dear Turun,

I have been asked for a progress report on our studies
dose
fluphenusine by the FDA. Enclosed is a copy of
of high

their letter

and my

reply.

have terminated studies or high dose
fluphnnazine in this country. and that the supplies from our
special formulation are exhnunted. To complete the records at
the FDA, I would appreciate your lending copies of the reports
from Missouri and Istanbul reflecting on these experiuncen.
These should be sent to Dr. Gardner.
As

I understand,

Many

we

thanks.
Sincerely yours,
-2 '

a:

1‘

Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>TSNY:106

Elmer Gardner, M.D.
Bureau of Drugs
Food and Drug Adninistretion
Rockville, Mhrylend

De”

M8?

11. 1973

IND

5210

A1.

The studies of fluphenesine at high dosage, undertaken
in St. Louis and in Istanbul, were completed in 1971. The studies
resulted in s number of internal menorsnde describing the effects
and some EEG and behavioral reports published by Professor T. Itil
of the University of Missouri.

The studies were suspended vhen they were completed; the
supplies of fluphenezine were either completely used in
the study. or used at lower dosage in the clinical csre of pateints.
Bo stocks of high dosage fluphenezine exist.

initial
IRD

5210

this letter, I an notifying Professor Itil that the
is hereby suspended; and shall ask him to forward to your

By

office, copies of the reports of the studies for your information.
Thank you

for your oooperetions.
Sincerely yours,
Fink. Mons
Professor of Psychiatry

MEX

mf/

'

�</text>
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                    <text>7333-3701

June 15311. 1973
‘

Wan Itilg Md)”
meso'uri Institute or Payehieery.
51:09 Arum Street.
-

at. Main.
Deer

museum‘s. 63139.

Tue-en...

Eneloeeﬂ it e emery which I presented at the
menace course of me Teehmlosieta. The only stew thing
in Table 5, which in the new mite their. I presented et

the

ECDEU.

Hem

mm.

here 0:1
I expect Dr.
as I am:
him mt. the meetings in Boston We agreed that he had
misunderstood me. for I ma aid that every compound tint
we had tested has shown the am behavioral eerrelation;
only 01-63. fer mien we have em mime]. dete, but no
human evidence of efrieney,
to be tented.

mine

W bﬂt regards.
Sincerely yew: .

Pink. 34.1).
Profeeeer of Fayehietry

Mex

Ill/1.1

ﬁne.

�</text>
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                    <text>7383~669
Mhy

17th. 1973

The Honorohle Janna Buckley,

Senate Office Building,
Washington, D.C. 20510.
v.

Dear Soother Buckley,

w

—-—~—»v,v.n.r

-wr"

my.-r-v——~.7Hm-—..‘_—..W_

During the poet few years tho President has sought
support for diaeontinoing research training funds. The
impact of this effort on research and teaching in fur
ranching, and Ruprosentativa Paul Rogora has introduced
legislahion to rovursa this Prenidential deoiaion.

I should low like to solicit your support for
56h0, ”The hationul Research and Traineouhip hot I!
1973”. whoa its oqnivalant is introduced in tho Senate.
HR

nv_'-

wrvnwrra

"ﬁlmy-u.

“rs"?‘r‘r

“V

-5

lo

.
.

._.

'v'ApWV&lt;"vr)-..«~WT"¢V‘.VM,.

This bill would raster. research :nd teaching fellowship:
with a) a ceiling on tho total amounts to‘he spent. h)
a proviso for a return of two years of service for every
or three years of support.
you: of mop-orb and c) a.
Such provisions should ovaroomh most of tho objection: to
the pruvious yrograml.

we

This bill would allow continued progreoo in the
devolopuont, through research, of safar and more effectivo
drugs for treating various illnonoen and for the heat
applications of drugs for tho treahnont of patients by
pruchioing physicians. These are matters of concern to theta
of us who consider ourselvns as clinical pharmacologists,
but in the broadar View, this bill rill assure a continuing
flaw of researchora and teachers for all fields of medicine.

.—

Thank you

n

.

for your courtesy.
ﬁinooroly yours.

'W‘m’I-nmwzlvvx

&lt;

n—

r
-

Fink, M.D.
Professor of Psychiatry
Mn:

W:

vaqun»

WW

.v

MF/iJ

�</text>
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                    <text>TBI~672
M3?

Tuna

PK 319.

Ital.

17th. 1973

34.13..

Hheidiyekoy,

Istanbul.

Turkey.

Dear Turan,

I am leaving fbr Europa an June lat, and will be
in Athens until whursday, June 7th. At thc momnnt.
I an schodulad ta arrivn in Istanbul on the afternoon
of Friday, June 8th. It I mtintnin this schedule,
I would like to be dbl: to acct with you thtt attains.
I hold tn open ticket for Istanbul, Ankara and rcturn. and
ha?» set using the veekand tad Botany to upond with you
3nd in Ankara.
I should sign the contract fbr my house on the
morning of June lat. and than last: it and all its
prdhlums to Martha. In Athnna I can be reachnd through
Pratouaor 8tothnis,(6ka~2025. or 801.0891 (hunt). I
hep. your trip to the Orient and around the world was
caniting. and I 1001 forward to spanding noun tin» with
you. (I hnvt been nndblu ta dbtgin a reacrvution at the
Hilton for iriday Jun: 8th. Perhaps you can enquire
or nuke a reservation at tnothmr hotel fur an. Mhny
than!!!) I
Mb'bcat rtgsrdn

to Ellen.
ﬁincerely yours.

at Fink.
ul/id

MOD.

�</text>
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May

17. 1973

Mt. G. C. Knnznan
IBM

59 Maiden Lane

New
,

York City

Dear Mr. Knnznan,

.v
~

"r-w-uw

4—4va

._
:w-x.

v
vw

.-—~.

V‘W';

I would be grateful for your assistance with the two
enclosed statements sent this Association for payment. In part, I
an turning to you because I seem to lack a business office contact
in Haeaau~8uffolk.

is now increased from a monthly charge
lack an explanation for this change. Last
month, we did receive a statement marked for $0.75 and the note that
it not be paid. Can we get an explanation 7
1. Invoice F276765

of $32h.00 to $32h.75.

We

2. We moved the IBM 1800 from its location at the Rev York
Meaical College at S East 102 Street on Decenber 7, 1972. Each month.

I

have corrected the invoice

Installed at:

'

"-‘

‘
“12'7"

-n-"'n'"7.‘"""-“V"‘

.m‘mm'vmwmww

The invoice address

Department of Psychiatry
Health Sciences Center» Surge I
BURY at Stony Brook
Room 2310
Stony Brook, Haw York 11790

is correct. I

these invoices before
Thank you

in the appropriate location to:

we

would appreciate correction of
take further action.

for your assistance.
Sincerely yours,

1m”

TW‘S'WW‘WM'WF

mmbwwuw

Pink, M.D.
Eeceutive Director

Max

�</text>
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                    <text>'

7333-675

my 17th;

1973

'ur.janay‘ubia.
003.3? 0611080 I

humility. mm.

M ”I Vain

-,

m

m

fmr
IIIIII' of Ayn-11 29th
I VIII to thank
I would bI very much interested 1n raving InoIhIr
IIudInI mixing with III, I In mm. It IhI prIIInI
to fund Inch I poI1I1II. II I hum
mm on
two yams IIIiIIIIII. I Ila-III IhII yam mad he Mutt“!
hum In 99901-1:me to
Io win-.1 mhool. Rheum
11111: Stony Brook
I would ho «lighten! to meet
Ibo kind of work Inn is going on
you III In Ihov
WC.
Rh1-1I

an

m
am,
m

:3 but. wishes

turf

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WI,

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11.9.

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�</text>
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                  <elementText elementTextId="106738">
                    <text>m—w—mmm—ww

-

mm

W‘

'm 1"4w‘im—v‘m‘v-‘mm—.~..»m&lt;

1...—..v

,«(u'mvnr &gt;\'

u‘meInD-v-wuvru—vep

7383-671

W 17th.

1973

Richard L. Teylor. 24.13.,
Apt. 202.
6621 Bonnie Ridge Drive,

Baltimore,

Md. 23.209.

Deer Doctor Taylor.
When

I reeeived

Proceedings of the

your request for a copy of the

we Conference. I

knew

that

it use

not available. Indeed. the documents have recently
been sent to the publisher end the volume "thobiology
or Com-ﬁve Therapy", editea by melt, Richmond
linemen, and William. will be published by v. H.
Winston and Sons
No

of Yeshington. 11.0.

ebout November, 1973.

other proceeding. are eveileble et the present time

until that voluee is published.
should you wish to obtain e different overview of
the EC? prone“. I ”agent. you look at the speciel

ism

of

Warner:

umber 1, February. 1972.
Thank you

I edited. value

for your inter-out.

Sincerely yours ,

’1“, ”OD.
m
Professor of Psychiatry
HIP/13

It,

~—.~—_-w.n.m.--...u n

r r,"

n—

.uvc—nwmy.

a. e‘

�</text>
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                    <text>7383-4376
May

NW,

1973

Profuse): J11-1 Roubietk ,
10109? Labombory ,
Harem
melon ,

huh .

"\“V‘rul-P

‘

Switzerland .

Dar 51:1,

mvrnvv

nr-rv

1‘4

,

Volta has shared with me his experieneea at the
meeting: earlier this math. He was very much
impressed with tn. quality of work now in progress in
Europe, but Micnlarly with thud: which you and your
swarm: Dr. muses}: are carrying out. As you 1mm.
I have command to apply our period and povor upcctnl
and the complex autistic: assumed ”by Don
mania
Shapiro to the problem of defining drug effects.
Voita bulima that your mthoda min a. positive

m

contribution to drug chasiﬂcu’sien, and I am interacted
in visiting with you on one of w forthcoming trips
to Ezra”.

I plan to

be in Europe for this we meeting: in
and
should you be back in your laboratories
Harlem»,
right after the meeting. perhaps I cauld Arrange a visit
them. Alternatinly, I expect to be in Europe min
about October 25—27%. and I could. visit you hater. or

after.

Finally, would you have any reports written by
yourself or Dr. munch I would
copin.
particularly of thc report 3m presented which so

twists

1m..'.d 701%...

I hm mod

aw

W

ummory sixty

City. to the
In York
have
bought
I

miles east of

and the mantra". This
I mom heme which overlooks the
water.- It 1- much taller than the an. you visual, but
has a. special
at mm less than ten minutes

M
it

We

�Professor

Jiri Wink

~2~

May

17th,

1973

m.

from the University. Baum. Linda still hu two
to so in tho schools in Grant Rock, I will try to mat-sin
both homes. The girls are growing up - Rahal should be
going to college next. your. Jon is completing college
this month and is planning to so in Stamford for Wm“
work in seeing. He bu Mm particularly unrated
1n the geology of the desert. A: a. sidelina, he has
learned to fly, and mum and I are both pleased with his

progress and plans.

vary

Eartha. and the girls Join me in wishing you our
to you and to Narnia.

but

My

best regards,

Simmly yours.

Fink. DMD.
Professor of Psychiatry

Max

WI 13

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                    <text>.,

"worn,”

7333~670
Mir 173k. 1973

,
.rr-v

lam-7711"”

migrrwvawgwt_wxxwvy

:mvrm

Thu Honarablo Lester ﬂblff.
House artiee Building,
whiningtan. D*C. 20515.
Dnar Royresentativn Wblrf.

During the past few your: the President has sought
support for discantinuing roscareh training fund... The
iamuet or thiu airbrt on rotonroh and teaahing in fur
roanhing. and Ropruuantuttvn Punl angers has introdnaed

logialntion to rcvnruo this Prcsiatnttnl decision.

I Ihauld

new 11k:

to ucliait your nuppart for

Sﬁko, "Tho 3:316nn1 Ranaaroh and Trainacnhip Act a!
1973". This bill would reutoro rosaarah and teaching
tillawuhipa with u) n ceiling on the tomnl umounta to be
HR

apcnt, b) a proviue fur rcturn at tvu ynars of service
tar avery'yuar of aupgortt and c) a limit of three years of
support. Such provisiana uhonld avuroann most of the
obaaetioas ta eh. yrsviou: programs.
This

bill

would

allav aantinned prograsa

anvulopnnnﬁ, through rcnenrnh.

at

1n

the

gator Ind more effective
drug: fbr treating various illnecnos and for $hc bent
appliastionl at drugs fur uh: traatunnt at patients by
practicing phytiainns. Thanh arc unttarl of aoneern to those
of us who eonsidnr ourselvun ‘3 clinical pharmacologiuta.
but in the broadsr View, this bill will :naure a continuing
flaw of renegrchers and toaahnrn for all fields of medicina.
Thank you

fbr your aaurtety.
sinaarely ynura,

ﬁnk. NJ).
m
Protesuar of Psychiatry
MF/id

�</text>
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                    <text>TwB-G’Th

“I? 1T“! .

W. Minn.

m“ R. J:

W

1973

61110:.

Contact: Moment
mama and Contmta

Brunch.

Katmai Indium of Rental Health,
Putnam Bldg. , Roan “YO—~26,
5600 Fish.“ Lane.
Rock‘dllo.

but

Mr.

WM 20852.

Re: 38!! h2~70-115

-

Well.

1

-

-'

22'

‘

Attached we 12 wpiea. of a formal application in

to m-m~m~73~223, «titled "Emlmtion of
name
Maﬁa Antagonists” . m: application is to be

command a, moral a! BB)! bib-76415.
New» of tho' that contain“. ammu- this
amputation u u preliminary mm“. mbjcct to modification
(1-: may) by the apps-mint. summation of the 8m :1;
Stony Brook. Ho rowan radar of this appliention, and

it is submitted to meet the W 29.
inﬂated int!» an.

1973 daadlinc

award: yam-a ,
Mu

rink,

11.1).

Mum- ot Psychiatry
10/13

:36.

o

�</text>
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M 23156.. 1973

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Fur-m"

Mr. Gary Boycr.

cent» for Studies of narcotic: and Drug Abuse.
National Inwituto of mental Earth,
5600

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bur

Mr. Boyer.

Lane,

wanna. Maryland

20852.

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nah
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Dr12mg

Ken‘b'

worm”:
Centaur,

Retinal

Salt Esta c1gggébunty Hamlin Dept.

1% East 611: south, 7‘
8:11.13ka @113, Utah 31111.
Eon: Boater aﬁﬁnnon,

‘if! @he gape: en ”Hareatie Antaganiats” requesﬁed

Ew'yeu will nab be avn11able un111 yubl1ahad by the
Eutiana1 Caun1in1en‘in the summer of 19?3. I suggest
yen vr1te to tEn cummias1on tar augmlqmanta, when
uwi?
.ainoerely yours,

Pink. M.D.
th
Prefosaor of Psychiatry
13/13

�</text>
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                    <text>7333680
”‘1’ 29th .. 1973
Al Heisman, Ph.D.,

Pfizer Inc. .

Gretna, Connecticut

MAJ-9‘

I very

much

«mom your

of the drugawry
new drug identiﬁcation.

bun
seemed so extensive. that I
3mm
and to
an writing to thank you far
M10112:
drug interactions

at the

ECDEU.

33'

Your

for

u

ask whether you cauld make

your
copy

a.

an.

«0:1th. to m.

few years ago. Sun Irvin organized a. similar
at the ACEP, and I understood he mtcd to
u but I do not rec-.11 seeing
If he did
pal-Mp: there is room for mob o. volm, with

session
publish

A

it

not,
report- ,nmilur to

it.

then presented at

ECDEU.

w but roman.
Sincerely yours.

ﬂax

rink, NJ).

Profouor of Psychittry
Mir/13

�</text>
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731:111
29. 1973

HIV

Albay Dr. Soviet Akpiner

Celikkele Sakai

3/ 10 Hailey
Ankara, Turkey

Dear Dr. Akpiner.

I very much restet that I will be uneble to Join Dr. Itil
end yourself st the etert of the study of OR? 8063; but I look forward
to visiting you in Ankara later this eulner.
There is one udditiou to the protocol that would be most
In
our eneeyu of OR! 8063, we obtained sole blood couple. and
helpful.
were dble to correlate the EEG effects over e three veek period with the
that
blood levels or the nettbolite at on! 8063. We would like to
blood senplee be collected during this study. prepared es follavu, end
stored frozen until the ena or the study when I will arrange with you to
how: the total staple eiruehipped.to the 0.8.

at

the protocol, please add the following: At zaah vacation
0: Achcduud, pee-dug, and at the and 05 the (but and
med
05 autumn: (page 1). count 10 cc. blood in a dean tube;
To

mm mmmWAmMadwwc
max
in mew!

when an EEG

Wéuge,
(much hue puuLouALy

shipment

a mutated.
Should Lt

actuated at the end

been tab

be.

‘

(male,

05 the.

and atom:

1. Place

an additional Ample

pat-dang

WW

peeled.

‘W be

should there be unusual expense: incurred in

please discuss these with Dr.
My

best regnrde,

Itil.

end £8813,

thie procedure.

I look forward to visiting with you.
Sincerely yours,

Mex

cc: Turen

Itil

Fink, X.D.

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29th. 1973

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M.

Gallant, H.D.,

Mme University

School of Medicine.

Papa-taunt of Psychiatry and Neurology,
1160 Tulane Ave. ,
Haw Orleans, Louilitna 70112.

.mu‘

r
..r

Dear Dan,

I very much angered year hospitality in New
I a: taking the opportunity to than);
yen for your effort on our behalf. I know hm: much
ml: 1% 1., and the «tundra! you not will be a. turd
cm to match in the caning matings.
‘

Orleans,

and.

My

ﬂanks. and

my

best regards.
Simerely yours,

.'V:'~"""!‘-‘Vu‘l

Fink, M.D.
m
Professor of Ptyhhistry

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June 18th. 1973

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