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                    <text>7éSB~OA7SB

30 January 1975

Alan 6110:, M.D.
Scientific Dovclopunnt Group
H.V. Orsunon

0.8

HOLLAND

Dear Alan:

Earlier this auuugr. when w: aura doing our pilot sunning
I rccaived three botclns of tnbloca laballad Bottle

of

GB~9A,

is

658283.

1, Ho. 2, and no. 3. Each conﬁninad 100 tablnts, green,
unleorcd, approximataly 7/32" in diunoter. Th. packing number

Ho.

since

Wu

.

did not an. than; tablet: in our dons-finding studies.
tha design.

we changed

Rather than send than back or destroy than, I would be
you could identify the contents of each Inctla-no
at: than. in out further sending. (Ono should be

grataful if
that u. may
5 mg GB—9h,
Many

one 10 as

anitriptyline,

and on: placebo.)

thanks,
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mix

MF/ciu

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                    <text>7683—04688
30 January 1974

Mary H. Smith. M.D.

Dcportnont of Psychiatry
Colloso of Modioino
Albert B. Chandlor Hodical Center

Univorlity of Kontucky

chinston,

Kontuoky #0506

Boat nary:
The next ﬂoating of tho-Anorican Psychopathologicol Anoo~
ciation will bu hold March 7 and 8 at tho Benton Sheraton hotel.

topic in on avoluotion of psychological therapies. Tho program format has boon changed to follow tho model so: by the ARRMD,

Tho

tho proaoneationo hoina diocuoood by a ponol
tho two days of tho station.

I look forward to analog

who

will sit through

you thorn.

Sincerely youxa,
Fink, M.D.
Professor of Psychiatry

Max

MP/cia

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                    <text>7488-05453
30

January 1974

Huntington ﬂavor, M.D.
Soorotory
Eaatorn EEG Sociaty
Hanover. Haw Eampohiro 03755
Dear Dt. ﬂavor:

I am writing to raconmand Jon Volavka, M.D., for samba:ahip in tha Eaatarn EEG Sociaty.
I first mat Dr. Volavka in 1968 on the occasion of a visit
to his tonaorch iaboracoriao in Prague. I invited him and the
director of tha laboratory. irofaaaor Roubiook, to visit our
laboratoriaa at tho Now York Madiool Colloza—-an invitation
which :hay both oooaptad following the unwarrantod invaaion
of Cnaohoalovakia by tho Russians. Dr. Voiovka has workod in
tho laboratorioo a: New York Modical College since 1969 and
during thia tin. ha: baon my oaaociaco. I laft tho Collaga in
Soptombor. 1972, and nine. that data ho has acaonad raoponni~
bilicy for ongoing programs in drug dopandonco and alootrophys~
iology.
ﬁn is a wall trained and highly oxparionood invaatisotor
with special talents in aloctrophyaioloay, statistics. oonputor
processing. and the pharmacology of opiatao and cannabis. He
was on important contributor to my studies of ECT and the EEG
attacks of opiates and cannabis.

is a
I: EEG

antatn

pianoura to raeomnand him for aamborahip in the
Society.
Sincoroly youra,
Fink, H.D.
Profouaor of Psychiatry

Max

MP/oio

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                    <text>7583.04583
30 January 1975

M. Bursar. M.D., D.Sc.
680 Madison Avonuo
Now York, Now York 10021

Frank

Door Frank:

I am pleased to enclose tho reprint that you roqueotcd.
will be ploasod to know that the use of EEG for idonti~
fication and classification of new psychotropic drugs in being
actively pursued in a number of industrial laboratories in
Europe. including Schoring in Harlin, Sande: in Basel, Organon
in Holland, and a laboratory in Genoa. I would be glad to discuss this work the next time we moat.

You

Best regards,

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mﬁloio

Encls.

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                    <text>7453*04353
30

Fred Andcrmann, u.n.
Montraal Neurological
3801 Untvcrsity

Mbnttatl, P.Q.

strnet

January

197&amp;

Institute

CANADA

Dear Dr. Andtrnann:

I

pleased to sponsor tha report ”EEG and Behavior Effects
of Naltraxonc in Man.” which in baits submitted for presentation
to the Bastcrn EEG Mbctinx by my £023.: coworkor, Jan Volavkn,
am

Md).

work

‘

I hope that he will have an opportunity to present this
in the next matting.

Sincerely yours,
Fink, M.D.
Profcsnor of Psychiatry

Max

MF/cis

cc: J. Volavka,

M.D.

�</text>
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              <elementText elementTextId="58832">
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              <elementText elementTextId="58833">
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                    <text>7433-04833"

31 January 1976

Pierce,

Graca

M.D.

Ortho Research Foundation

Raritan,

New

Jersey 08869

Dear Grace:

Encloscd are the curriculum vitae of Dr. Dincman and Dr.
Sungurboy. I would appreciate your adding than. to the IND

amendmsnt
my

for the Itudy of

033—3063

in Iatanbnl.

boat regards,
Sincerely yours,
Max

Fink,

M.D.

Ptofassor of Psychiatry
MF/cis

ﬁnals.

�</text>
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          <element elementId="50">
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                <text>Correspondence to: Andermann, Fred</text>
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              <elementText elementTextId="58818">
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              <elementText elementTextId="58820">
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          </element>
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            </elementTextContainer>
          </element>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58822">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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              <elementText elementTextId="58823">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="106863">
                    <text>January 31, 197‘
Costa. Stafania. M.D.
Univaraity of Athana School of Mbdicina
Athana. Graaca
Boar Coataa,

Enéloaad are topics of the two summaries which wt
submitted to NIDA yaatarday. In addition, VI aunt 16 voluuaa
of tha data output: (the material that
brought last spring and
tho output: of tha work dent by Aria this auanar) as v.11 as
copiaa of the raporta which ﬁt made in 1971 and 1972. I
boliava that the reports warn wall aactptcd. although Rhaa
told ma of many quastiona that wara rained.

it

I have aakad hat to list the quastiona and as soon as
I have then , I will aand than on to you. If tho NIDA
allow: an axtanaion, wt may be abla to Intuit a daftnittva

roport. hopafully written together. which may answer
chair qua-tiona as wall as our own.
Plaaaa «stand

Athana.

my

hast wiahaa to out

many

some

frianda

of

1n

Sincerely yours,

Max

Fink,

M.D.

Protester of Psychiatry

mf/ca

�</text>
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                    <text>7483~05083
1

February 1974

Health Research Council

1020
125 worth Street
New York, New York 10013
Room

Gentlemen:

I on writing on behelf of Dr. Rhee Dornbush. who is applying
for a fellowehip. I have known Dr. Dornbuob since 1967, when
who joined me in our ongoing studies of the effects of seizures
on brein function, memory, and behavior. I have known her on
both supervisor and coworker in our studies of cannabis.
Dr. Dornbush came to no unusually well qualified in studies
of memory function. In our studies of convuleive therapy. she
set up numerous auditory end visual tests, eeeoseed the date,
end provided the enelysee which hire been published.
During our association we beceme interested in the effects
of cannabis on brain function. From 1969 to date, the has been
the principal investigator in the cennebie studies at the New
York hedioel College in which we have eeeeesed the EEG, memory.
end beheviorsl effects of both acute and chronic administration
of cannabis. Because of her expertise, Professor Freedman end I
celled upon her to assist on in the studiee of "Chronic Heehish
Users in Greece"-o contract established in 1970 by NINE. In
this study the was called upon to guide the organization of the
study, relate to the scientists in Athens, provide for the col“
lection of date, enelyre the information. sod prepare the erten~
eive reports. This study program has just been summarized end
submitted to NINE. and in this summary the major effort was hero.
She is s highly intelligent and unusually well qualified
research investigator. She writee well and is well liked by
her coworkers and seeietento. She is able to extract coopera—
tion from the most diffioult of patients and exhibits eque—
nimity and e pleeesnt mood even under the moat execperetins
circumstances. Indeed, her diplomacy bee frequently been put
to use. both by Professor Freedman end myself, when we have
found it necessary to relate to governmental agencies.

-1-

�Health Rgeearch Council
An

~2~

1

Februaty 1974

a coworker, Dr. Dornbush he: made major contributions

to our study programs. As e principal investigator, she has
exhibited the drive, judgment, and enthusiasm necessary to ac~
canplish the mission: which she has eet. She is experienced
not only in experimental peychelogy, research design, and etatietice, but also in the problems of human research.

I have no reservations in recommending her for the fellow*
ship for which she is applying, and I know of no member of my
staff who in better qualified than she.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF/cin

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                    <text>7483~05883
1 Fabruary 1974

Paul Kinlholz. M.D.
Profnsoor of Psychiatry
Psychiatrisohc Univornicﬂtoklinik Banal
4056 Basal
Wilholm~xloin-8trnﬁe 27
SWITZERLAKD

Door Poul:

should bu possible for Dr. Gastpnr to work with us this
coming summer. Most of our work in dovotod to the recording
and onnlylis of tho 226. Hi havo no oxpertiso in can or roo~
piration. There are, howovor. soiontioco on this campus who
are wall known (Bernard Inrcky and Milton Lodge). and thoy night
be willing to have Dr. Gaotpar visit. From my oxporionco hora.
I boliavo he might be interested in spending time with Dr. Ax
in Detroit. for he has a fine reputation in poychophyoiology.

It

Should Dr. Gnltpnx be intornstod in working born, I oug~
tell no sonothing about his experience and who:
ho would like to nchiovo in a visit homo. If I can, I will
respond by suggesting tho kind of work that would haip him and

soot that ho

ho

consistent with the
Thank you

work

in the laboratory.

for thinking of us.

My

boot rosardo,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

H31

MF/cia

�</text>
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                    <text>7&amp;83w04983
1 February 197‘

x. E. Sting. Blanca:
ﬂaw Dinnnoionn

Backnnn Instrununta. Ina.
2500 Harbor Boulcvnrd
tullcrton, California 92634

Dear Mr.

Stine:

I would 11k. to tats advantasc of your 15-day frat trial
offar for BEG~1, "Eleatronicu for EEG Tachnicinnn.“ Hi can
wait for it the 60 days, when you anticipate it will be available.
Thank you.

Sinethly yours.
Fink. M.D.
Professor cf Psychiatry

Max

MI/cis

�</text>
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1 Fabruary 1974

Gustancr Strvieaa
John Wilny and Sons
1 Wilsy Drtvo
Somerset, Haw Jutlcy 08873
Gcntlcnnn:
Eneloocd plcasc find a copy of John C. Pinhnr'u Encrgz Crisc$2 Pcrugggtivq. as wall as tun invoitun you cant with tho book.
1: not tbs hook I ordarod; in
I an ruturnins the book as
of
otdgrud
Dnccubcr. I
a eepy
gainta Addiction: Origins and
Treatncnt by Scynour Fishar and Alfrud Frcodamn. This '8. a
Halotod Prat: title, and prapayuant of $8.96 (spatial ptiec
to members of thn Amnrieun 601103: at Rouropsychophnrnneolosy)
was aneloaad with my ordar. I an 0:111 waiting to: this book.

it

Your prompt

ciataé.

attuntion in thin nattar will be

most uppr¢*

Sinccroly youru,
Pink, “.0.
Profaanor of Psychiatry

Max

MF/ctl
33:10

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l

Fabruary 1974

.

M

t

.

.

a,“

my.

”Flux"

1::‘--»v-..;v:‘.\pw:nmr.'.-.

r
u

Murray Weinar, M.D.

Vice Pranidnnt-~Rss¢arch
Laboratory Sciences and Clinical Pharmacology

Marrall*National Laboratories

Cincinnati,

Ohio 45215

Dcar Murray:

I will

either you or Peta: Siegler
ara still interested in stadium of antihistamines.
I am not planning to attcnd the NYU alumni wanting on February 23,
as I will be away on a ski trip. I can man: with you the wash
of the 25th. should you b: staying ovcr.

visit am.

my

bu delighted to have

We

best rcgarda.
Sincerely yours,
Pink, M.D.
Profassor of Psychiatry

Max

MF/eis

�</text>
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.1».

—p.my u»-w.&lt;-:yv .-

,

.7

“w- "rm-“WWW”.

u..-—n

_

..

‘

.

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74AP-055AP

1 Fahruary 1976

Jocoph Zubin, Ph.D.
722 Has: lésch Street
New York, Haw York 10032
Dear Joa:
and

I

I

havn recatvcd the Naninatins Committee Import from
writing to thank you for your help.

am

Prita.

I undgrstaud from Jon that thd Johns Hopkins Prue. V111
oxhibit thc APPA volumes at tbs Boston anoting. W111 thoy also
exhibit the earlier, Grunt and Strntton isoucaf If not, would
you 11!: to atrnngc that in tons way?
My

bgst regards.
.

Sincerely yours,
Max

ﬁllet.

Fink,

M.D.

�</text>
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                    <text>74AP-056AP
1 Fobruary 1974

Samuel B. Guzé. H.D.

Dapartnant of Psychiatry

Washington University school of Modioino

St. Louis. Missouri 63110

Door Sam:

I

writing to thank you for your holp 1n the Nominating
I have rccatvad a roger: from Frits, and I think
tho suggestions at: orcollcut.
am

Committaa.

“rm-aw»?

,.Vr-""~"v&gt;-‘

.

I kocp heating disturbing hour from 8:. Louis. We wore
visited today by one of tho young fnychiatristo from Malcolm
3110., who tussestod that com: of the cans restriction: on re~
search visited on the HIP at. apparoutly being establishad ac

Bliss. Fran thin distance of 1100 miles, can would wonder if
a concertod effort by IU, M0. and SLU would not be called for,
not only to help HIP ourvivc but to provide a dam for the "knownothing" mantality of middle Hisaouri.
my

thanks for your help,

sincarcly yours.
Max

Fink, M.D.

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>7hAP~05ﬁAP

1 February 1976

Eric: Freyhen,
2015 B

Street.

H.D.

R.W.

washinscon, 0.0. 20009
Deer Erich:

I

for the report of the nominating Cam—
mittee.
feels that he can eccenr
the
aieeion as Secretary for at least one more year.
plieh
went to thank you

I have spoken to Jon and he

I have asked

him to put the Q;

for the next council meeting.

subscription

on the agenda

the Johns Hopkins Pres: will have an exhibit
at the forthcaming meeting. I suggested
the: Jon inquire as to whether it would be possible to put copies
of §g_with a subscription for: either at their exhibit or in one
alongside. Should you think it is a good device. you may wish
to have copies (7 complementary copies) on exhibit at the meeting.

I

of the

am told that
APPA volumes

Again,

my

thenke for the nominating Committee report.

Sincerely ycure.
Mix

Mrlcie

Fink,

M.D.

�</text>
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                  <elementText elementTextId="103835">
                    <text>February 6, 1974
Bank ven

Risren.

NJ]. Orgenon
Oss. Bollsnd

lest

M.D.

Bank.

This week-end,

I

was

invited to so eanivsrsery party

and bed the opportunity to have dinner with Dr. Dorothy
Krieger of the Mount Sinai Hospital Medical School. Dr.
Krieser is well known for he: hormone studies and we
chatted about the polypeptide research scene, David deWied,
and eventually OI~63.
She expressed an

interest in using 01'63 in the

treatment of Addison's disease. In the discussion. I
added that I held the IND and she immediately asked if
Not being
she could get some material for human use.
such
for
a
use. I suggested
sure of the proper procedure
wanted to do,
what
she
no
that she write a note telling
how
could
and
I
cooperate.
you for advice.
have
I
would
be
s long
useful,
If you believe this study
would
be
and
husband
not
I
and
her
her
with
acquaintance
advice
studies.Your
her
and
encouraging
her
adverse to visiting

Should she send

My

this on, I will write to

7

best regards.
Sincerely yours,
Pink, M.D.
Professor of PSychietry

Max

�</text>
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                    <text>February 4, 1974
Thoma: A. Hayct, M.D.
Butcnu of Drugs
FDA

Rockvillc, Maryland 20852
Dear Dr. Hayes,

Raf:

IND

8569

had submitted the formulations of the placcbo of
thu ntudy of OI~63 earlier. Evidcntly the docuncntation
hud not rcnchod your office. WI would ho grateful if you
would check the records at the FDA for the oritinal submission,
and trust that the data will be sufficient for the review
We

you envision.

For tbs meanﬁhile, we have indicatad that the placebo
is not to bc used and atudies may continue using a
saline (normal) control.

vnhiclc

Sincerely youra.

Fink. M.D.
Professor of Psychiatry

Mix

miles

�</text>
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                    <text>habrnary 5, 1974
Book vac Riezon, M.D.
N.V. Organon

Oas, Holland

Dear Bank,
We

have been notified by the

FDA

that the use of the

placebo formulation in the study of 01-63 and placebo should
be discontinued, until they have had a chance to evaluate the

placebo.

I have called and discussed this modoege with Joyce.
indicates that she has used the material in two instances.
Rather than wait for a decision from the FDA, she indicated
that the study could proceed as wall with normal saline. She
believes that the data will remain valid, that the evaluators
will not be in a position to see either injection, and that
she could procacd with saline.
She

I agreed.
soon

you.

I trust that this judgement meets with your approval.
as I have heard further from the FDA, I will write to
my

best regards.
Sincerely yours,
MAX

Fink,

M.D.

As

�</text>
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                    <text>7488*05983
6 ¥obruary 1974

Dr. Victor Toichnor
Dopaxtuont of Psychiatry

Hotropoliton Hospital
97th Strooc and 2nd Avonnc
Nov York, Now York 10029

Door Dr. Toiohnar:

I have

known Dr. Alvin Bronson

both acudonto at

How

since 1942,

York Univoroity.

'

whoa no were

During the past two years. he has boon working in the nar~
cocic addiction unit of tho Department of Psychiatry at New York
Modioal 001103.. Dr. Cronaoo in a oophiatioatod and careful
psychiatrist with exocllont training and oat-asivo oxporiooce.
Ho aocopted the challenge of working with narcotic addicts and
hot done a oomnondablo job.

I

would recommond him

plying without rcncrvation.

for tho position for which Is is ap»
Sincoroly yours.
Pink. M.D.
Profeaaor of Poyohiatry

Max

MF/ois

�</text>
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                    <text>.
J...

4‘

W

7488~06188
6

February 1974

Joyce 6. Small, M.D.

Carter Mbmorlal ﬁoupltal
Street
Indianapolis, Indiana £6207

Laruo D.

1315 was: 10th

but: Joycc:
In checking our records, we can only recoumnnd two report:
which arc relavznt to the problem of maincannnca ECT. Thane are:
Geoghcgan,

J.J.,

alactroahock.

and Stevenson.

Amqgg

6.3. Prophylactic

J. Paychlat..

105:694~é96 (1949);

Karlinar, W., and Whhrheim. 3.x. Maintnnanco con—
vulsive trcatmnnts. Aunt. J. Paychlat., 12121113~
1115 (1965).

Gooshognn and Stevanson 1: the only

satisfactory article.

I

havn discuscad our cxpatlcnce with Dick Abrams, and he
of no EEG studies with maintenance BOT and confirms the
shaman: of adnquata control studina.

knows

my

best ragards.
Sincercly yours,
Pink, M.D.
Profeusor of Psychiatry

Max

MP/eia

�</text>
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                    <text>7483—06288
6

Mr.

Charles Schultz

Burcuu of

narcotics and Dangerous
v.3. Departunn: of Justice
555 West 57th Street

February 1976

Drugs

ﬂaw York. New York 10019

Dear Mr. Schultz:

Enclaacd is a copy of my roapnnno to thc
from the Drug Enforcenant Adainistrntlon.

letter of

Rovenbur 12

In chacktng the paper: available to me frém A3008, I have no
rnacon to changa my opinion submitccd on thnt data.

sinearoly years,
Pink, M.D.
Professor of Psychiatry

Max

MF/eis

Encl.

5‘
-~.

.swn

w,

r‘g-n

”Ir

wm

-,—

�</text>
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                    <text>A.

-

s‘mm'”

7483*07033

11 February 197$

Dr. John 8. Tall

Ptcsidtnt
Stats Univcrnity of
Stony Brook.

Dear Dr.

the

Haw

York
York 11790
New

Toll:

I an planned to neccpt your invitation for

Campus~W1do Counitcae on Raacarch

mambcrship 1n

Involving Hunnn Subjncts
and look forwata to participating in tha work of tha Committee.
Encloncd

raeords.

is a

copy of my curriculum

vitae for your use

Sinatraly yours,

33.5,.

.r.

M

wt,-

“v

,_..

Fink, M.D.
Prof-snot of Puyahiatry

Mn:

«4r

uh.

."..;m"

«

HF/ctn
Encl.

and

�</text>
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7683~06983

11 February 1974

Hillar, Ph.D.
Psychiatric Institute

Lyle R.

Eastern Pcnnnylvania

Henry Awanno

Philadelphia, Pennsylvania 19129
Dear Lylo:

Bank shared with an your letter of January 22, and I am
pleased to lend you a copy of tho summary or our axperience:
with high doses of OI~63. a: you requested in your latter.
The only unusual CBS utfacz was the transiant dcvnlopnnnt
of bursts of 3-5 cps, 80—150 uv uqunrins for 5-30 seconds nonn—
uhnro about 50 minutau attnr aha aﬁminisztation. The-a bursts
ﬂute chart and nﬁli—limitod and did not appn&amp;r again for the
raunindcr o! the obsnrvution period. This absurvntion was made
in thrnn subjects-1n on: it was very alas: and in two it was
found only on careful ruvicw of the racords.
my

boat rcgarda.
Sincerely yours.
Fink. K.D.
Professor of Psychiatry

Max
«w

v;
'1
n1.

5
»-

'r-z

:
yﬁmv'w-‘W

war

MF/cia

Eacl.

�</text>
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                    <text>74 AP~071AP
11 Fohruary 1974

Gerald L. Kleruan, K.D.

Professor of Psychiatry
Harvard Radical School
hoasaohuaerrn Gonoral Hospital
Boston, Masaachuactts 02114

Boar Gerry:

I havo received your lcrtar of February 6 rogarding the
relationship barwocn the APPA and Comprahcnsivo Psychiatry.
While this problem has been discursed many tiara, I believe
the response of the publinhnr to Fric: to our recent inquiry
is the first time that tho publisher hot boon willing to
considar a opacial subscription rate for APPA mombers.
Tho question of editorial policy, the appointment of the
Editor, and nominations for the Editorial Board are matters
that were discussed. Fritz was able to satisfy the questions
of the Council at that rims. Suhacqucnc to that mooring, the
officers of that period (1972) were appointed to the Editorial
Board. The appointncnt of rho Editor, howovcr, second out~
aids the purview of tho Association.

I have aokod that rhiu mortar be put
I look forward to the discussion.

on tho agenda, and

Sincorcly yours.
Max

Mﬁleis

cc: Dr. F. Froyhnn

Fink,

M.D.

�</text>
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                    <text>7453-07283
12

rahruary 197k

M E HVO R

A.N

To:

Wilton w.-Shroava, M.D., Ph.D.
Acting Associate Chief of Staff for Raunarah

D U H

VAR-Hoxthpor:

Fink. M;D.
Protaaaor of Psychiatry

From:

Max

subjact: Propoual of Dru.

Sn and Boson, "Molecular Modal

of Morphina Dopandanca"

Ra:

632/151. 2/1/74

is a basic acianaa investigation of hypotheses
of abronic opiate use.
tho
pathophyaiolosy
eonaarning
The study

Dru. Sn and Boson propoaa to no: tho oholinargie aspacta
of the nouronnscular junction of rat diaphragm to stamina the
oignifiaanca of acatylcholinc inoraaaa in dependence and ab~
atinanaa. The study in wall daaignad. tho nathoda are faaaihla,
and tho authors hart axparicnca in using these nathods.

prison: version of the yroyoaal is very much improved,
with an axonllont rationale and a more detailod praaontation
The

of methods.

Tho study does not involve human

subjects.

The authors toquaat tho VA to outablish the laboratory and
request no funds for pataonanl and only limited ouﬁpiina during*
aha firat your. Thu oaoond~yaat augment in modaat, consisting
half in aquipuont and half in taohniaian support and supplies.

Racoamaggation:

If ch.

VA

in ahla to provida basic science

laboratory aquipnant for a nonrpatianc~oara effort through itsand
establiohad grant machaniama, than tho hodgat is appropriate

relevant. avan mode-t.
Approval
MF/cia

is

reconnaodad in the amounts raquaatad.

�</text>
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  </item>
  <item itemId="5862" public="1" featured="0">
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                    <text>7488-06683
12
Mssami

Saito,

Fsbtusty

1974

M.D., D.Msd.3ci.

Dspsrtocnt of ﬁscropsychistry
Xsnssi Msdicsl Collcgs
Ossks~Horixuchi

Jspsn

Door Dr.

Ssito:

The world Congress of Biological Psychiatry will be hosting
Aircs, Scptsmbsr 26~28, 1974. Following soon discus*
sions with combats of the Program Committsc, I proposed to the
Secretary. Dr. José Ysrvurswlobiss, that wo hold s symposium on

in

Buonos

the suhjsct

Qusntitstivs Electroencephalography and
Psychoshsruacology.

This auagsstion has been sccsptcd. and I am writing to in~
you to psrticipsts in this symposium. us would hops to
focus on both ths methods now in nos for qusntitstivc EEG. as
well as applications in classifying psychoactive drugs and tho
nontally ill.‘ Our aim would be to describe the cathode now in
use and the lstsst data to highlight olectrophysiologicsl methods

vita

as applied to biological psychiatry problems.

as arc not planning to request funds for participation and
on csch participant to providc the means of sttcndsncs.

will count
The

invitees include:

J. Rouhicck

Basal. Switcsrlsnd

D.

Rossdini

Genoa,

T.

Itil

Istanbul, Turksy, sod

14.

Motousck

Gﬂtsborg, Sweden

-1-

Italy
Now

York City

�Mo

831:0,

MOD.‘

nomad. $91.

12 F.bruarl_ 1974

”2"”

G. Dolce

Datustadt,

L. Goldscein

Rutgers,

C. Shagaaa

Philadelphia, Pennlylvania

J. Volavka

New

York

Gnrmnny

New

Jorsey

City.

Should you be planning to attcnd tbs Congress and would like
to participate in this symponiuy, I would b. gratoful for your
raply befora March 31.

Sinccroly yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>7483~067SB

13 February 1976

Dr. Jiri Roubicek
Neurophysiology Laboratory
Sundae Pharmaceuticals
Basel, settlerland

Dear

Jiri:

Enclosed is a fotmnl invitation to participete in a symposium
at the forthcoming World Congress of Biological Peychietry 1n
Buenoe Altos. Should you b: planning to attend the Congress, I

would be honored

if

you would share the

izing the session with

me.

responsibility for

organ—

To that and. should you have additional euggootione regarding
the perticipento or the focus of the tee-ion (Which I believe will
be three hours in length), I would be grateful.

the least. t tan and I decided the: we would entertain
the pettioipents in some feetive way. and we would be pleased to
have you join us in nuance-Aires.
At

My

beet regards,
Sincerely yours,
#’

Me: Pink,

“.0.

Profeeeer of Psychiatry

HF/cie

ﬁnal.

�</text>
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                    <text>76$B~07683
13 February 1974

William Guy, Ph.D.

Coordinator for

ECDEU

Data Analyses

Univoraity
Bionotric Laboratory 11501 Huff Court

The Goorge Washington

Konninston, Mhryland 20795
Din! 3111:

I an pleasod that thorn will be a togionol workshop for
battery. I would like to send our data coordinator,
Minn Shorty Thompson. to ottond. Unfortunatoly, I will bo away
from my laboratory during that wank. Miss Thompson boo not had
direct oxporionco with BCDEU forms. for on have sobnittod a pro~
toool to tho VA Roooaroh Connittto and it is boing oonnidorod
now. nor principal oxporionoo is in the evaluations of the VA
tho

ECDEU

Cooperativo LAAMFHotbadono Study.

If it would be appropriate, I would like to have hot ottond
rational workshop to booono familiar with the ECDEU battery.
If this is inappropriate, please advise me. and on will make or"
rangcnonto at a lotor tine.
ails Thompson is ablc to attond on any of tbo date: listed
tho

(Pabruary 26, 27, or 28). I would be grataful
vino bar diraotly. Her nddroau in:

if

you would od~

Word 64A

Hospital
Rorthport, How York 11768

VA

(516) 161-4600 x2517.

Thank you for the invitation, and
from tho experience.

will benefit

I trust that

Miss Thompson

Sincoroly yours,
Fink, H.D.
Profo-sor of Psychiatry

Max

MF/ois

cc: 3.

Thompson

�</text>
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                    <text>7583—07383
13 February 1974

n

E M O R A R D U H

To:

Stanley P. Yollco. M.D., for walton W. Shrcava, H.D..
Ph.D., Acting Aaaociata Chief of Staff for Raaoarch,
VAH~Notthpott

From:

Max

Fink. M.D., Profcaaor of Psychiatry

Subject: Proposed Studios of Alcohol Dapondance at VAB-Northport
were urged to develop studies in alcoholism
at VAR—Notthport to oupplomant the ongoing rascarch weafforts 1n
proposad
the treatment of opiate dopendenon. In Soptanbor,
a notion of studies to answer thrno questions:

Last guano:

we

tolerance dovalop to long-acting
bannediasopinoa?
Docs

Boas coloranca to a bonnodinaopino pto~
Vida "blockade" to alcohol (by cross-

tolarance)?

If such blockade occura, can it be put to
clinical use tn tha maintenance of chronic

alcohol~dapandant Iubjocta by high doses of
a lags—acting bonnodiasopine?

In this projact.

wa proposed

to no: a

new

bonzodiachinc,

is particularly promising because wc
hava obaarvou a duration of action that in conoidotably longar
than other known bonaodiaaopinaa, nonaurcd by clinical observa—
I have extions, KEG oxaninntiono, and blood level studies. Unitad
States
tonaiva axpartenca with this compound, both in tho
OR!~8063. This compound

and Turkay, whora

cally acttvc.

I

havo found

it

-1-

to ba Info to use

and

clini-

�YolleslShreeve

13 February 1975

-2~

Since submitting this proposal, on have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of
the experiment. I believe we have answered the design and safety

questions satisfactorily.

In Decenber the Committee requested that we give than an
nunber; 1 indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971. referred to studies than approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
protocols to the FDA for repeated administration of the drug in
can. These studies have not only been undertaken but have been
published, and include two reports submitted to the Committee:
"On

the Anticsxisty Properties

of'a

New

Benso~

gygg;.Thsr..Rss., 15:
288 (19?3). In this study, Sskalis and his
co~workers have given 0R3a8063 for 21 days from

diasepins,

oar—8063."

30~150 as a day.

-

"08F;8083, an Early ﬂuctuation of'a Haw Anti—
anxisty Agent.” Curr. Ther. Rust, 14:664 (1973).
In this study, Gallant and his nodworkers re—

ported the treatment of

8

chronic alcoholic

inpatients for an average of
to 160 as daily.

25 days, from 10 mg

In addition to these two published studies, I have submitted
capies of reports of my own work; and indicated that I an personally aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day. in a study which I am
aonitoriug in Istanbul. I also attended a conference (June,
1973) at which 7 investigators (including Sakalis and Gallant)
presented data on varying dosage schedules in man for extended

periods.

in requiring a letter from the FDA justi~
tying this study. is asking for a procedure which the FDA does
not ordinarily follow. In this request. I believe the Committee
is exceeding its charge. Should the Committee persist in this
denand-that we obtain prior approval for a study from the FDAr—
the centers would abrogata their responsibility to decide whether
a study should or should not be dons at the VAHrHorthport on the
data presented. Continued insistence on IND approval as a pre~
requisite for studies will not facilitate research at VAR-“orthport and will not establish that hospital as a center for human
The Committee.

studies.

�YollcsZShtnnvc

~2~

13 Pabrunty 1975

w-mw

"'Wrwwwr»

I halicvu that the Connittcc salad «ﬁnitely in its original
ruquast for 130 duct; tad that I aattd unwingly 1n attunptins to
lag: thslr dcuand. I hulicvn I! havo submittod sufficient in—
foranttan to warrant the judgnoat that the study should be approvud. ¢nd nah your udv1¢o is to the aux: stop for us.

M3/cil

3-th

�</text>
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                    <text>it,

February
Rdbert Robinson,

M.D.

A. H. Robins Co.
1&amp;0? Cummings Drive

Richmond,

1971;

Virginia

23220

Dear Dr. Robinson,

the initial dose-finding studies
of ARR-2277 and are satisfied that single 10 mg doses are safe and
elicit systematic, dose-related EEG changes.
We

have completed

have also completed the assays of the canparison
substance, haloperidol, and are satisfied that single 6 mg doses
elicit systematic effects. We believe that this dose may be above
threshold, hooever, and we are exploring an additional group of
We

subjects at

It

mg.

enclosing a copy of our work-sheets rOr your
information. I have asked my staff to summarize the data of these
initial studies and a report will be sent to you as soon as it

I

am

is completed.

‘

Should the h mg haloperidol doses be below threshold,
we will undertake the comparison, classification study of placebo,
AER-2277. and haloperidol using 10 mg and 6 mg doses respectively.
that dose will be
It the h mg dose of haloperidol is satbsfactory,
used. In either case, the systematic study will begin before the
end of February, and should be completed in 2 months.
Thank you for your

patience, and

my

best regards.

Sincerely yours,
.v

,A

.uy

WNN'W'IV‘wh-rrw-u

-

Fink,
th
Professor

M.D.

of Psychiatry

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                    <text>7483-07583
14 February 1976

Patricia 3.

Gay. Ph.D.
Committee
Search
Chairman.
Rutgers Univcraity
Collage of Arts and Sciences
Camden, Now

Jersoy 08102

Dear Dr. Guy:
on banal! of Dr. Rhos Dornbush. who is boiug
of tha Dcpsrtnant of Psychology. I have
Chairman
considered as
known Dr. Dornbuah sinus 1967, when she joined no at the Now
York Modical College in our ongoing studios of tho offsets of
saicuras on brain function, canary, and behavior. I have known
bar as both suparvisor and co—workor in our studios of cannabis.

I an‘writing

Dr. Dornbush cans to ca unusually wall qualificd in studies
of nanory function. In our studios of convulsiva therapy, aha
sat up nunnrous auditory and visual taste, asasaaod tho data,
and providad the analyses which have been publishad.

intarastad in tho affects
to data, aha has bean
of cannabis on brain function.
cannabis
studios at the ﬂaw
tho
the principal investigator in
During our association

wu

became

From 1969

York Radical Collaga in which u. have assessed tho EEG, nanory.
and behavioral affects of both acuta and chronic administration
of cannabis. Bananas of bar axpartiss, Profsasor Frasdman and I
called upon bar to assist us in tho studies of "Chronic Hashish
Doors in Grasca"-a contract astablishad in 1970 by NINE. In
this study she was called upon to guide the organisation at tho

Athans, provida for the col~
laction of data, snalyra ths information. and prapars tho extansivs rsports. This study program has just boon summarized and
submittad to KIME; in this summary the major offer: was hora.

study.

ralsta to tho sciantists in

intolligant and unusually well qualified
rcsasrch inwsstisator. She writas wall and is wall likad by
her covworkars and assistants. Sha is abls to axtract nonpara—
She

is

a highly

tion from the

most

difficult of patiants
-1.

sna oxhibits cquaninity

�and a plugnnnt mood uvan undcr tan not: exacpcrating circun~
stances. Indoud. ha: diplomacy has frequnntly been put to use,
both by Profocnor Irocducu and nynalt, uhan V! have found it

uneassary to relatc to savornnnntal antaciaa.
Dr. Dornbunh

is

an uncallnnt tuachnr and contributed hnnvily

ta our taaehins programs in biologieal psychiatry, where she pro~

lantnd the nathodology of relcsrch studies, statistics. and tbs
:01. of brain function in unwary. 8h. was well liked by ab:
stud-nun. most of when war: payehiatric rasidcnts.

a co~workar, Dr. Dornbunh has nude major contributions
:9 our study programs. A: a tenchcr and praject loador, aha hts
ancnptod ranponaibility wall and hat axhibitsd the driva, judgnnnt, and unthuaiaam nuc¢nunry to accomplish the a13sions that
war. act for but. A: a principal invcanisntor. aha designad
studios and carried than out in an axnnplary fashion.
As

,,

&lt;
.

.
u

.,

.
.u

I

havn no

reservations in rcaonnondins hat for a position

of loadurship. for I tuna that aha will examplity high standards
of reacareh and scholsrchip.

A...

Sincerely yours.

.4.

.y

A

V.

A.

r...

V
“

Max

"-7.,—

r

“mm—q.

"'~

.,

#,'V\I’§WI“W1~

,,...—,,V‘.,v-&lt;-—

..
m

Fink, H.D.

Prafcssor of Psychiatry

.,.,

HF/cia

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                    <text>7433-07683
16

rubruary 1976

H E M O R A N D U H

To:

Stanley F. Yollas.

From:

an: Fink.

Subjactz

John Kanlcy. H.D.

M.D.

H.D.

I than of thc work of Dr. Hanlcy. Thu curriculum vita.
ruflacto an catanaivu tachniaal background. with a hnavy ¢n~
phauio an ch: eonputational and dloetronic aspcct- of brain
wave recording and analysis.
'

It would be appropriate to consider him for appointmnnc
in the Departunnt. This 10 particularly truo whoa can look:
at Dr. Hanlcy's rccaut interests. aspacially tho contact that
ha ha: vacantly taught. no act-o to be saving in a direction
at not. general applications of his abilities.
I

would rcconmand that ho
:- soon as you deem

seminar.
Mrleia

visit us,

it

pathnpa presunt a

appropriate.

�</text>
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                    <text>7483-07953

25 February 197a

Prof. Dorothy Krieger

mount Sinai School of Medicine
Fifth Avenue and 100th Street
New York, New York 10029
Dear Dorothy:

I very much enjoyed our talk at Alice and Martin's anni~
versary celebration. Because I was puzzled by your comments
regarding the availability of AETE fragmenta, I wrote to my

coworker at 033, Dr. Honk van Riezen. He explained that.
through a series of oversighta, changes in administration, and
administrative enafuo. they had failed to send you the material
you requested. As the extract from Hank's letter indicates, the
fragments will be sent to you as soon as possible. He also is
interested in the rationale for trials of OI~63 in Addison's

Disease.

I

am

planning to attend the convocation on behalf of Morris

Bender on Friday, March 15.
for me to visit you earlier

to

visit your

fragments?

call

at #:00 p.m. would it be possible
in the afternoony~about 2:30~—first.
and its
perhaps your secretary would

laboratory and, oecond, to discuss

If this is feasible,

my

office at

My

best regards,

(516) 44A~24&amp;7.

ACTH

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cia

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25 February 1974

Edwin A. Whinstein. H.D.

Professor of Neurology
Sinai School of Hcdicine

Mbunt

Awenna and 100th Street
York, New York 10029

Fifth
New

Dan: Ed:

I look forward to joining you
tion of Morria' service on Friday,
Thank you

and Mbrria at ch: comaemorn‘
March 15, at Hbunt Sinai.

for your invitation.
Sinceruly yours.
Fink. M.D.
Professor of Psychiatry

Max

MF/cis

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27

deruary

197a

Mr. Arnold Cantor
Andrdw Stuart Associate:
P. 0. Box 325

Purchase,

Now

York 10577

Dear Arnold:

Solootrlc I typewriter.
Ho. 1078) was stolen from the
black, Serial R0.
17. no have notified the
laboratories on or about February
invostigotions, and I believe
police and carried out our own
this is a single act.
IBM salesman to bid on
In surly Daoomber I toquosted on a newt: model and was
against
an sachaago of this typawritor
$175 as a tradaoin.
was
value
maximum
told that the
for your
I trust that this information is sufficient

that an
I regret to report
#551870 (IAPR

IBM

records.
My

boot regards.
Sinouroly yours,
ﬂax Fink, M.D.

MPloin

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                    <text>7483-08183
27 February 1974

Joyce Small, M.D.
Larue D. Carter Memorial Hospital
1315 west 10th Street

Indianapolis, Indiana

46207

Dear Joyce:

In looking through my notes for loxapine, I find that it
by Lederle Laboratories (a division of American
Cyanamid), Pearl River, New York. Unfortunately, I have no
relationship with the research people there.

is manufactured

Enclosed are a few
I checked

meeting.

citations from the recent literature

ItilECDEU

notes and found that
on loxapine and the EEG at the 1973
You may wish to call him for his experience.

on loxepine.
gave a Verbal

report

my ECDEU

I have spoken to Holland. and they will ship additional
01-63. I have not yet heard from the FDA regarding the placebo.
They have received my notification, a copy of which is enclosed
for your files.
go to Europe on April 1 and will be stopping
at all helpful, I could present a progress
and, if there are any problems at that time,
statement to
perhaps we can maﬁa adjustments in the protocol. I will call you

at

I an scheduled to

One.

If

will be
itBank

a few days before
My

my

departure.

best regards,
Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

MF/cia

Encls.

�</text>
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                    <text>7583*08088

27 February 1974

Peter J. Fell,
Head

M.D.

of Modicsl Affairs

Fianna Limited

Bnkowoll Rood, Loughborough

Lsioestsrshirs, LEll

OQY

ENGLAND

.Dsar

Peter:
accommodate Tony Croft in our ls~
during tho second half of Mirth. w: will set up a

would be pleased

We

boratories

program which

to

will ineludo observation of our data collection

and data analysis methods, experience in running oxpsrinonts,
and an opportunity to srtofact rscords. Ho may loatn as much

as he wishes about the data analysis, including the statistics.
be spproprinto. we will also go into dstsil with toShould

it

I left anything out?
to visit other laboratories while he is

sard to the behavioral data analysss.
Do

you wish him

here? If so,
.

till he make

Have

the arrangements or should I?

to accommodations. I boliovo he would enjoy the Three
Village Inn in Stony Brook. Rooms cost 312*15 per day. Other
imitations" and have slightly
‘hostslrios arc all~modnrn "ﬂiltonaccommodations
wish
at the Inn or
Should
you
tariffs.
higher
the othar motsls, please let me know.
As

‘

;
'

N

you give him the sons instructions that
you~~to phonn no at 516~644~2447 in the
(daytime or, svonings, st 516~751~é665 or 516~466—5544. I will
probably suggest that he take s limousins to Stony Brook or
Great Neck, depending on whats I so.

I

would ask

that

I originally left for

cal-

�w.

75:.

wwwv—Ju-ﬂqv

wuv

P.

J.

F011, H.D.

-2~

27 February 1974

In confirming these arrangements, 1: would bu helpful if
you would give mm can: information as to Mr. Croft’s background
and training, as well as spacific additional quaationa which
should bu studied whila he is here.
my

bunt regards.
Sincorcly yours.
Fink, M.D.
Profcsaor of Psychiatry

Max

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                    <text>7hSB~0825B
27 February 1974

Fridolin Sulaor,

M.D.. Chairman
Credentials Committee
Yrofcssor of Pharmacology

AGE?

Vanderbilt University
School of Mhdicinn
Hashvillc, Tcnnnaace 37217

no:

Dear Dr. Sulsor:
AER?

Albert Hbissman, Ph.D.

pleascd to spanner the electicn to membership in tho
of Dr. Albert Wainsmnn.

I

am

I havc known him and his work for at lean: seven years, in
his role as pharmacologist at Pfizer Inc. When I studied tbs
naurophysiological affects of doxcpin. thiothixsnc, and CP~1£,368,
during
I found his avaluntions moat hclpful. At various times
ACE?
aha
equally
found
his discussion: at
thesa many years I have
of
nathodology
the
pre*
useful, particularly an to inderstanding
EEG
and
clinical «valuations and their relationship to clinical
asausamancs.

publications attest to his cxpcricncc. and I believe
that as a Fellow he will centributc even morn than as an annual
His

guest.

Thank you

for your consideration.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

Encls.

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                    <text>“.4

.
,-,

_

_,,_w&lt;,,_,,,.c..,..,,

.
_
A

I

February 27. 197“
Coataa Stefania, M.D.
Eginition Hospital
Thens, Greece
Dear Costco,

before the

APA,

Enclosed is the

official

acceptance of the report

to be presented in Detroit

I

invited to

on May 9.

first
of April, and should be free on April 11 to come to Athens
for as
many day; as it may be useful. I should have the results of the
ongoing analyses with no at that time. If that period is convonlcnt
fOr you, I would like to moot with you and to work to the extent or
the time available to us, anticipating completing the discussions
in ﬂew York than you cone some weeks later.
have been

Europe

for the

ten

Is that tins convonicnt {Or you ? (If not,
defer our meeting: mtil you cone to the United States.)
no. In

If it is, I would like to bring
that agreeable to you 7
my

we

can

Dr. Dornbuah with

boat regards.
Sincerely yours,
Max

days

Pink,

14.1).

�</text>
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February 27 , 197h
Robert Robinson, Md).
Robins Co.
1&amp;0? timings Drive

A. H.
«wry-Ir:-

Richmond, Virginia 23220

rm.

Dear Dr . Robinson,

I wrote av note of February

for a week's holidwe,

rev—reading.

and

Just as I was leaving
I understand the lack of clarity on
115

are eatiafied with the single 10 mg dose of
safe and as having central effects. We are unsatisﬁed
with our evaluation of haloperidol. Most of the studies were done
in a short (2 hour) session, and we have since extended the session
to five hours.
We

AER-2277 as

In these extended sessions, the 6 m3 and the h mg
haloperidol were both, sufﬁciently unpleasant ,that we have gone back
to the 2 mg dose, and these assessments have been in progress this

week.

I regret my optimism. We are still exploring the
lower dose: of haloperidol. As soon as we are satisfied, I will call
you and aek that you assist us in setting up the deﬁnitive atuchr.
If we find the data clear by the end of the coming week, we ahould
have a report by the week after (March 15). But we will hit proceed

without further consultation.

W best regards .
.u—w

Sincerely yours ,

‘11

m

W"

Fink, 24.1).
Professor of Psychiatry
Max

,—

_,.,_

,v-u

‘

I;

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                    <text>-,

mane,

H." u

,

_,

.

'u-v;»

_-., -V'~.‘.:-"ﬂV-WHW'Vw'm-WYW-‘err—«q'
.r-

"IL-1 wa-

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am...

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February 27 .
E. N.

Terry,

Dear

Skitch,

1971*

M.D.

Phsrme-Resesrch Canada
Points Claire 730, P.Q.

I am embarrassed that we have completed the data.
analyses, but hove not set dam to write the updated report. The
new analyses confirmed the relationship between FRY—3641. and
amphetamine, and after the consultants were happy with the results,
we were so pleased that we immediately med the data analysis model
for two other studies-—- the withdrawal of hssnish in chronic
smokers, and the relationship of EEG and blood level date. in
volunteers receiving diesepsm or bromssepsm. These analyses have
been completed and again we are delighted with the results, suggesting
that the use or the stepwise linear regression model may indeed

be

helpful.

I

have asked

my

staff to

update the report on PRF~36-CL

within the next two weeks. Should this be time enough for your FDA
submission, I would ask you to wait. If not, you may wish to add these
data as a supplement.

I am most grateful for your support and confidence
in these exercises. I believe we have learned a greet deal, not only
about PRF~36—CL, but about the methodology as well.
My

best regards,

and

my

thanks

50:-

your patience.

Sincerely yours ,
Mex

Fink,

14.1).

�</text>
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                    <text>741~0841
27 February 1974

IBM

Office Products Division
366 North Broadway

Jericho,

New

York 11753

Att:

Gontlemcn:
Ono

of the

IBM

Mr. Jay do Lauren

Soloctric typewriters under maintenance con*
from our laboratory. A description follows:

tract has been stolen
IBM

Soloctric 1, carbon ribbon

Color:

Machine
IAPR

Ho

Black

Sorial

4551870
1078.

Number:

Decal Number:

woulo appreciate your listing this machine as stolen
it from our maintcnance contract, offoctivo this

deleting
date.
and

Thank you

for your cooperation in this mottor.
Sincoroly yours,

.v,-.

x
‘

:._

Max

4;.

17er

shown

«pa-or

Fink,

M.D.

Executive Director

.cwx-w-

MF/cio

�</text>
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                    <text>7&amp;33-07333
28 February 1974
M

E

M

0

R A N D U H

Shreevc. M.D., Ph.D., Acting Associate Chief

To:

Walton

From:

Me: Fink. M.D.. Professor of Psychiatry

Subject:

Proposed Studies of Alcbhol Dependence

at

W.

of Staff for Research, VAH~Northport

Last

summer we were urged

st

VAH~Northport

to develop studies in alcoholism

VAR-Northport to supplement the ongoing research

the treetnent of opiate dependence. In September,
a series of studies to answer three questions:

efforts in

we

proposed

Does tolerance develop to long-acting

bencodiesepinee?

Does tolerance to e benzodiseepine pro»
vide "blockade" to alcohol (by cross-

tolerance)?

such blockade occurs, can it be put to
clinical use in the maintenance of chronic
alcohol~dependent subjects by high doses of
e longvacting bencodiecepine?

lf

we proposed to use a new benzodiszepine,
This compound is particularly promising because we
have observed a duration of action that is considerably longer
than other known beceodiezepinee. measured by clinical obeerva~
tions. EEG examinations, and blood level studies. I have ex~
teneive experience with this compound, both in the United States
and Turkey, where I have found it to be safe to use and clini-

In this project,

ORE—8063.

cally active.

-1.

�w. W.

~2-

Shreeve,ph.D.,,Ph.D.

28 February 1976

Since submitting this proposal, we have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of the
experiment. I believe we heve answered the design and safety
questions satisfactorily.

In December the Committee requested that we give them an
number; I indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971, referred to studies then approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
FDA for repeated administration of the drug in
men. These studies have not only been undertaken but have been

protocols to the

published, and include
"On

two

reports submitted to the

the Antionrioty Properties of‘a

diasspine,

268 (1973).

ORE—8083. ”

Committee:

ﬂaw Benso~

Curr. Ther. Res“

15.-

In this study, Sakslis end his

co~workers have given ORE-8063 for 21 deys from
30~l§0 mg n day.

"ass-8063, an Early Evaluation of’a New Anti—
ansisty Agent." Curr. Ther. Rsa., 1§:664 (1972).
In this study, Gallant end his co~workers re~
ported the treatment of 8 chronic alcoholic
inpatients for an average of 25 days, from 10 mg
to 160 mg daily.
In addition to these two published studies, I have submitted
copies of reports of my own work; and indicated that I am per~
sonslly aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day, in a study which I on
monitoring in Istanbul. I also attended s conference (June,
1973) st which 7 investigators (including Sskslis end Gallant)
presented date on varying dosage schedules in men for extended
periods.

I believe that the evidence already submitted is sufficient

for the Committee to determine that ORF~8063 may be given in
multiple doses-ssfely-to men. I am enclosing a copy of en
IND

submission dated

Msy

30, 1973, received by the Bureau of

�w. W.

Shrcsvo, H.D., Ph.D.

~3—

28 February 1214

Jun. 1, 1973, roflecting on a protocol which requires
the multiple—dose administration of this compound to psychiatric
patients for periods up to six wneks.

Drugs on

Committee acted unwisely in its original
data and that I acted unwisely in attempting to

I believe that the

request for

IND

demand. I further believe there is sufficient informa~
Committee for
to judge whether such a study
could be undertaken at tho VAH-Horthport.

meet

their

tion before tho

MF/cis
Encl.

it

�</text>
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                    <text>7453-08683
28 February 1974

Dr. John S. Toll

President

S.U.H.Y. at Stony Brook
Stony Brook, New York 11790

Dear Dr. T011:
would be pleased to servo on tho Unlvorsity~w1do committee
concerned with controlled substances on the campus.
1

You may recall that Dr. Pollogriuo asked no on May 20, 1973,
to assist investigators in complying with the appropriate rogu~
lotions for the use of controlled substnnces, and I have had some
communication in this regard.

Thank you

for the invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis
cc: Dr. Oaks

�</text>
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                    <text>7383*73383
1 October 1973

Turan m. 1:11, M.D.

?rofesaor

and Associate Chairman
of Clinical Neurophysiology
5action
Chiaf,
and Psychopharmncology

Séhoel of Hbdtcina
University of Missour1-Columb1a
5400 Arsenal straet
St. Louis, Missouri 63139
Baa: Turan:
The pragxam

to participating.
my

for the

ACMP

Is ancellent

and

I lack forward

best regards,
Sincerely,
Fink. M.D.
Profasaor of Psychiatry
Max

HF/cis

�</text>
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3:33:11 panal team.
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program.
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best regards,

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Ha: Fink. K.D.
Professor of Psychiatry
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                    <text>Catcher 2nd, 1972
F. J. Kuhn. Finns,
Departannt at Ph¢rnteology,
6507
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Whit Gar—any.
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for your letter or Boptanbar 7th

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but in rngdin; t3. reprint I agree that this
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mt Pink. 3.0.
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                    <text>7

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‘n-I'J‘" -q~w-.-u an'r “w,

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7383-738~33

15 Octobar 1973

M E K

0

R A

H D U H

To:

Stanley

Prom

Max

I.

Fink.

Yollca,
11.».-

M.D.

w

Subjact: Tanhiatoacopa, Cit. and lvant Ctntrol Syatan

.

The

taahiatoacope and CF! arc davicas that proaant visual stimuli undar
rigorous control of input variablaa. This paruita tho capatinantat to
naaaura accurataly the Itata of vigilanca of a auhjact and tha lavcl of
brain function parfomca. Chang» in than manna at. diract indicaof organic noutal states and tho affacta‘of drug: and paychiatrit traatmanta. Thay are alao being appliad as a nan-are of the ahanxaa producad
by tha aehiapphtanic ptocaaa. For exparinaatal atudiaa by uadieal ata—
danta and follows. than: davicaa ara invaluabla both as roaaarch and an
taaching toola.
(a.

The Evan:

Control System permit: ch. roaaatchar to present stimuli

through the tachiatoacopa or CF?) with tigeroua central of dura~
tion ..and aaquanca factota. thus permitting careful aaaaaanant of changes
in vigilance, brain function. and tha long~tarn cifacta of paychoain.
This ayatam is also applicabla to tha projaetad studios of conditioning
in our capandad narcotic addiction resaarch program.
HF/cia

�</text>
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                    <text>«can. -...— wu-r.

»

.

11' I'th-c—d

,

amp-gaymmur—vmmwwm»-mu.-.—W-ww

"NC-r—

»:vvwmr—

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c,” wum-mwwye

'r“_l-~vnr\A-iu—u"—-Hpi'rr7"':nv.')cc|mn

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w...

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an

73SB—739A

October 15, 1973

Alan Ramsay,

3.9.

medical Conuultant
Cantu: for Studias of

Narcotic and Drug Abuse
Rational Institute of Hantal ﬁnalth
5660 Fisher Lana

Roam 11¢, Wayland
Ra:

HEM

20852

h2—73*269,

Dear Alan:

arc writing to rcqucst yarmiasion (a transfer the sum of $k75.00
v.5. travel to tareign trnvel to permit representation at the EEC-HA3
Connittaa on Problems of Drug Dtpendante meeting to be held in Matteo
City, Hatch llwlé. 3975.
from

we

Nb

believe that participation in that aceting would cantribute to

out otudy of thc narcotic antagotitto. As ycu know, these matting:
rcpruscnt tho tingle principal coavocatian of internatianal scientists
with intotctt 1n narcotics. and utttndanca at prior meeting. has been
most

useful.

Sincerely yours?
Max

Fink. H.D.

Praia-sot of Paychiatry

HF/cin

n.»—

n

.u c—‘~-W‘m"—t--’-—

�</text>
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October 15, 1973

Laonnrd 8. Brahon. Ph.D.. H.D.
Dir-ate: of Radical Ina-arch and léucntion
County of Nassau
Dcpaxtnnnt of Drug &amp; Alenhol Addiction
214 Glen Cave Rand
Carla Elude, Haw York 11514

Dist Lani

I rcsret thlt I will b. unable to attend the conference on
naltrexan. on.Ictober 25. As I inéicntad to your ca~workar. I am
leaving for Europe on October 22 and shall be away for thrae weeks.
I

hope ch.

slasion is fruitful.
Sincerely years.

an: Fink, 14.15.
trotcauor of Paychiacry
Kilcil

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                    <text>73APA9741APA

Octohcr 15, 1973

17}?

«V

lwzam'H-"a-W.

«r
Wt"

"m1“

W

"W'RP‘W

&lt;x&lt;wﬁwn~

Knrv¢y Blucntonn. M.D.

Bayartnnnt of Psychiatry
‘Ironx—chanon Hospital
1285

Fulton Avon“.

aroma.

New

York lOéSG

Dear Egrvey:

I-raarn: that I was unnuccoolful with A. B. Robina.
I have not heard from Dr. Clark. and in checking with his
aosociates I was told that the firm has no program for
the support of local noctingn.

L

EU

best rczardl,
Sincaraly yours.
ﬂax Fink, M.D.

Profalnar o! Payebiatxy

�</text>
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                    <text>7383~74253

16 Oetoﬁur 1973

J. l
104

A. Churchill
Glouccutcr Place

London

In:

m “E
Our

2.0. 036a2. August

A, 1973

mum:
Plnaso apprtaa In of tha status of tho abovu 0:40: for thrao

(I) copiu a!

man:

ville-Groom.

Wm“

11:

6111113;

vacuum by x.

Gran-

nopctully, Eh. order Ihauld ha on it. any to Eh. Bipartncuc
of Paynhutry. I! not. plan media in; 1:5 :3de for in»

amazon“. purge-u this

smart.

Thank you.

Simauly,

rm.
Profuse:
tux

I#1.

14.0.

of Psychiatry

�</text>
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                    <text>w‘W‘I—vw-v-x

w v~--

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rwgm.u—w~—.-rwm

‘....~.‘.

n-y.....w.mv~m~~r~r»mw.-—«um-=.m "1......” q-rrw.“

V.

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m--. rm... new

.

.

m.-." ...

WW..."

,,...,. . -

m.-

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October 20, 1973
-..mq-.

..A

John R. Hughes, M.D.

The Medical School
Northwestern University
Chicago, Illinois 60611

Dear John,

it has taken to review this volume.
I
to assess the meaning of the
began
until
It
two sections that interested me. I found myself reading and re»
reading the sections, and then it was a difficult decision, whether
I regret the time

seemed so easy,

to

be general or

specific.

I believe the review is too limited-— in part because
I am not well equipped to assess the other sections. For the
opportunity to review the Elul and John sections, however, I

thank you.

~

n.-)'.,r~

«ma»:-

Many

thanks for the invitation and the challenge.

1.7.:

«771'—

Sincerely yours,

“away-WM

W,

W

In:

awn-112M

Sw'W‘r'Wo

.nxrz'

_

WNW""I‘

Max

Fink,

M.D.

v

.

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.

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.,..,‘..

�</text>
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                    <text>7383*74483

17 October 1973

Mr. Konnoth B. Stohl
Box 1522. Station #2

Amherst, Massachusetts 01002
Dear Hr.

stahl:

Thonk you

artiolo to

and

I

for your latter of October 9. Since writing the

which you rotor. I how: loft How York Radical College
am nov at S.U.H.Y. at Stony Brook. Ho do how. o prosron of

research in the narcotic antagonists.

it is not oloar what aspect of the report
principal programs of this Division are in
tho study of the effects of drugs on tho human EEG as well no
spootfic ntudloo of opiates and choir antagonists.
From your

inccroats you.

lettor,
The

Ehould you with to come and visit, I suggest you call my of~
{ice and ottongo to v1.1: thia univoroity. I shall be away until

Hovonber 10, so should you wish

date.

to viait

it

should bu

aftor that

Sinooroly yours.
”ink,
an
Profoooor
HP/cis

HID.

of Psychiatry

�</text>
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                    <text>7353974583
17 Octdbar 1973

Hilton Groanblatt. H.D.
Chicf. rsyahintry Servten

Tutorann Aalinicttatian 89:71:31
Sapulvuda. Californtt 91343
‘35:

665/116, 10/3/73

9.:r Milt:
I am writing in rusponsc to your rogugat concerning
ance with Arthnx'Choxkin, Ph.D.

my

acquaint-

I became interested in some of his studies of unwary changan
1n the*chick when I was reviewing aha literature on 302. I first
Ist=h1m a: thu'wintor Brain Ensearch Conference in 1971. Suba¢*
qunnuly'uhnn I ers‘nixad tha Coufcranea an the Psychabialoay of
Conrainivu Therapy in Puaxto 1:06 in April. 1972. Art Chartin.v&amp;s
can of the inviﬁad participants. He presented his data well and
eontribuecd farcafully to thn discussion. Since then. I have
had a nunbar of cannuniantioas regarding aha reparts submitted
to thn walnut and havo diocuaucd with him a yoaaxblc program of
rascnteh in 308 which may be raluvunt to tha EC? procasa.

all then. alienationn. I have found Art Cherkiu to be knov1~
:dshlbln at tho literaturo. cupcrtcnccd in rusaarch, and critical in
hi: Judsnnnt at rituarch problnnl. My only cxparience regarding
his fanatics II a "team unattr“ wan at th&amp; Contarenac. where ha
partieigacsd nativuly and contributed niznifienutly.
In

unu:

I would have no huaitatton for ricolnnadina his for an appointat this Univoruity and eta anaerua hi: rcconnondacion to: UCLA

with ease and pleasure.

stnehrely youru.
Fink, M.D.
Protasnor of Psychiatry

HA!

'HF/eit

'

�</text>
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                    <text>7383—7663!

17 Octobar 1973

Dr. G. Dole.

c/o Laoaida Goldstcin, 3¢.D.
nutsuru undieal Sahaol
University Haishts
Piacntnuay, ﬂaw Jursay 08855
baa: Dr. Dulce:

I II dalishtaﬂ that you will b: in tha States during tho month
of Novanbat. I will b. :way until Rovaabnr 10. but I will be glad
to have you visit any day thereafter. P1513: call no at (516)-64b2447 after Huvunber 10 and v: can Irrtage a suitable tins.
my
v

best regarda.
Sincurcly yours.

'
"

:H

W

w"

Fiﬁ. HID.
m
Professor of Psychiutry

”my—w

wWWWNWI'I-p‘h

ﬁllet!

�</text>
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                    <text>}

i

7385*74383

17 Octobcr 1973

Br. Halter Rosana
Dopartnnnt of Paycholozy

Gallant
Flushing, now York 11351
Qunena

Dan: Walt:

Encloscd

of the can:

:- : ouunary which
Gordon'n valuno

to:

was publishnd

in

1969 and a copy

ray¢hophnrnnaolqg;¢al Aggnts, Vol. 3.

Attar you havo had a chunca to road
sonshla solution so tho dilunnn, pious:

that:

@111

and

an.

if that: 1-

Sincurnly yours.

fink, 8.3.
Protease: of rnychiatry

Max

Mrlcis
ﬁnals.

a ran«

�</text>
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                    <text>7385*75333

12 Bovcnbcr 1973

3313.11 Gordon. Ph.D.

3:13:01 Liberatoricn

P. 0. no: 657

Syracuse.

Butt

Haw

York 13201

Max:

Your progress with Voluno 3 is enunnnddblo. I htvn abackcd
the tgxt of my aontrtbution sud find that I huvh not taprodueod
nay mutatinl which has bean pnblichaé ptuviously in an idonttn
tiabln fashion; n» toqunst to publiahcra for petuinnian to re~
pradnnn Eh. nicotial is nacanacry.

in

I an tnprculad with ch. alcuably of fin: pharmacologiues
which you hﬂﬂl placad no. and I wish to thank you.

But mums,
sineotnly youru,
Max

rink,

M.D.

Profaaaor of Plychiatry

�</text>
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                    <text>November 13, 1973

Carl Salaman, M.D.
Massachusetts Mbntal Health Center
7h Fenwood Road

Boston, Massachusetts

02115

Dear Carl,

I have read the draft of the clinical report on
elctroconvulsive therapy and have made a few marginal notes. The
principal omission may be in the use and application of flurothyl -or, is that subject included in another chapter 7 For a practical

manual, such an inclusion
The

may

be helpful.

location of elctrodes is difficult to define

from the text. Perhaps you‘would care to include a figure, similar
to one used by.Abrams in a manual he and I produced some years ago.

only hesitation in reading the article came from
your hote suggesting philosophic differences. Except for the
editorializing on page 1—2, there is no disagreement as to content,
application, etc. Perhaps an examination of the usual ambivalence
towards ECT which the introduction reflects could be undertaken by
Dick Shader and yourself, and I am confident that you will arrive at
a more tutorial, professorial, attitude, suggesting perhaps that
in the absence of a more elegant method of symptom relief for severe
My

depressions, the success rate and the cost/benefit ratio of
clearly suggest its continued use.
Good

ECT

luck in your volume. I trust I will see you in

California next month.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>-hTr—ww

m'v‘wﬂv-

,

7383-75583

13 Havaubar 1973

Kr. Jﬂy

Hug
Expericncial Ybyniology Deparlnant
Vazcrann Adminiutration nanpietl
Ho

Sgpulvada. California 913é3
Dear Mr. King:

I r0320: the delay in analyzing ch: tape which you acne
to un. as 1: ttrivud whilu I was in Europa. We chuckgd 1t
ycntsrdqy and Sind Ehlt n. have no difficulty in replayins aha
tint-nave an «eh chm}...

m volugen wen aatufactary.

In ordnr to find tha record. um had to tawind tha tape
real. Apparuntly. sits: the signal: warn put an
the tape. the tag. van novud'by (an: fotward to the taka~up
real. and tho taka-um reel was can: to an. To ondblc us to
follow your sequana. of racorétng, u. ask that ch: tap. be
rcwauad and can: to u: from tbs left, or master. ruol.
unto another

Thank you.

sinautely yours,
ﬂax Pink,

8.9.

Profoaaar of Psychiatry

HF/cis

�</text>
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                    <text>731*7581

13 Novambor 1973

HE. Rs Jo “YWCJ-l

Contracting Officer
Contrscts Kansgsnent Branch
Rational Institute of thtal Koslth
5600

Fisher‘s

Lane

Rockvills. Maryland 20352
Ra:

BSM42~7D~98

Dsir Ht. Gradwell:
Encloscd in s oopy of s latter I have none to Dr. Stephen
scorn. reporting progrsss in the study "Chronic Hashish Users
in Graces" (35H 42—70u98). Progress on this study has bean
ontstsndinaly good. with the stooption that tbs timetable which
tho Committee insisted upon in Junc-oanaot to not without totni~
noting the study in an incomplote ttsse. I am, therefore, re~
qussting an axtension to April 30, 1974, and havs outlincd in
my lotto: to Dr. Saar: the tsssons thstsfoto and the
state of
tbs study during my visit to Athens on Novembat 7 through
9.
Should an extsnaion be possible. tho Association will prs~
puts the nsoasssry supporting documonta. Should the Connittos
rocouusnd tsrminstion on Doesﬂbor 31. us will submit s final
taport. oopias of all of tho dots. otc.. according to the oon~

tract .

Should you wish additional infatuation, I suggest you die—
enaa the progress in the study as witnssood by Dr. Stars and
3:. Smith during their visit to Athens in August.

It is a pleasure to work with you, and I trust we can bring
this extraordinarily incarnating study to a satisfactory tomplotion.
‘

sincerely yours,
Max

Hrlcis
Baal.

Fink,

M.D.

�</text>
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                    <text>w, .07

,m .....

V

wuw—r—Ir‘ev-‘vvr-SVW'V

‘

.7

'

r

-

'“‘*' '

"

“""

'

'

A

wnwr-vrw—w—wv-m-w

thaw'v'ﬁ.

W:

«an-Hm

7383~75488

.

www-gmr..~ru

13 Ravi-bar 1973

rmﬂdjn

5.,
~11.

0;
.

1_’J“V1Iv_

r‘l"’§"'

KB!

a-a'wnuﬁ

wm-wmmnn-r

lullagég

Publicattanu Inacarah Offien
Rational salons. lbundntion
Washington. 9.0. 20550

an
vw

1w;

Gontlanan:
so no

I would appruciato having cepins at the £8? Bullocig unit
at:
Depareunnt of Fuychlntry
School of ﬁadiaiua
Rnalth Scianecl Cantu:
8.3.3.!. at Stony Brook
Stony Brook, Raw York 11790

,
M»

5:,
A

mayﬂxﬁc

r4

1"

x
1W

7-;

:ggrf'r'vr-J"?

Thank you.

sinenruly ynuru.

-',.‘1;'

vzu-rwn

Max

Hiluiu

.-

rink,

M.D.

Pratt‘sor of Ptyahtaery

ywmmmmrlwx'vrmv'

�</text>
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                    <text>731~7S7I
13 ﬁavuﬂbar 1973

Dr. Stephen

Stir.

Bivition of Eutectic

and Drug Abuse

Rational Institute of Mbntnl Raulth

Fiahcr's Lana
Rocivillc, Maryland
5600

20852

as:

H3K42-7ﬂw98

Dcar Stave:

I have retutndd from a visit :0 tha-projact "Study of Chroiic
Kanh1sh Uaaro 1n Grcocn" (33H42—70~98) Ind I am writing to bring
you up to date with tha ptagruos.
As you knaw {run your

visit to

Athqa: 1n Augult. the study

callection at data in the tents experiments
in the early spring and the data were analyzad, both in Athanu
anﬁ Haw York, during the summer. A major pattion of the analysts
warn éonn than Dr. A. Liakos unwind in my laboratory for three
vodka in July. -WHon.hc luft, there wet: some tonidual antlynas,
and these Hath couplotad 1n saptlnber and sent to him.
team coupleteé tha

Beginning in Juan, aubjccts warn induetad into the with~
drawnl study and as of November 1. 12 aubjacts hast completed
thc aix~day observation period. I brought the EEG taplt back
to my laboratory on Hovuubct 12. The study tuna in Athens 1.

q.

nears-w

"yr—rm.

v..-

|

aontinuing with the inéuction of subjnctn in thin withdrawal
study and havn set that: tarsut as font additional nubjects,
{or a projactué total of 16. Thay do not baits?! that they
will be shit to ranch 20, but trait that 16 will provide 315~

niﬂieant data.

There have batn no changat 1n the ntaff in staff at Athens.
Despite aw leaving tha Haw York Mbdicnl 0011.31. my cedworkntl.
DrI. Dornbush. Crown, cud Volavkl, aontinua to contribute to
the analysis of that. data.
You should be Ivar. that except for the prsscntation at
thn 1972 818? nesting in Copcnhagnn and ruviuwu at the 1971 ind
1972 tasting: of the ACHP. this material has not bcan palsunted
or publish-d. In ptrt. this rctltctod a reluctance an tha part
of Professor Stefania and.uya¢1£ to prajudga tha data, and I an
culm-

�wanna—nﬁ— h“. 1—H.“ . Y. n-

Dt. Stqphgg Santa

platted

*2~

thtt wt hurl hnnitated. for

7..»

.

w

r. rum...

Wu“ "ﬂu”.r ”pp“,W—

13 Routnbat 1973

our viaws hams undcrgone

changes during the progras: of this study. Profasuor Stefanis
and I discnlaed at length the matter of practicing this material
and praiinionally wt hnvu decided that we will:
(1) truparc a summary for HIKE to supplement tbs
summarits aﬂbnittnd artliar and submit this
tunnaxy with duplicattn of tha data set as
soon as these ate Ivaiidbla.

balicvc that tbs data land thennalvua to
»approxinata1y six to sight prustatutionl Ind
publications in seicntiﬂic journals. and an
'lre prograssing with the preparation of theta
rcporta.
(3) Concurrent with thane two forms cf data ptao~
entntion.*wa believe that the ruports and mate
extensivn data than is stainarily providtd in
journal articles provide a legitimnte basis for
a significant vulva. on the affects of chronic
hnuhidh use in man, and W! plan to nah: sudh a
presentation. (This is particularly important
since the scientists nothing in the Juanita
study appnnutity adopted the utratuzy of pran—
entina their matarial in the pdblic praoa.
instally with regatta glowing tastimaninls of
the curacy of chronit hadhith use.)

(2)

Wk

I balicva that U! will need 1n attention of time if we
are ta attoapliuh the Idéitiannl {our nubjacta. Analyse tha
withdrawal data. writs thn report: to: publication, ate. I
tn aware that at our last Intting in Juae. you: associnta: «are
insistent that the study he annpiotcd by the and of this your.
Shauid this viuv rennin the official position, we will provide

all of thc data availibla to date, including tho with“
értwal dtta, in whttsvar stats thty any be on Decanbur 31.

you with

“a ptafot, howevat, that you reviaw the used for this ttruinn~
tiou, particularly in vita of the fins wart the Gtaok sciontilta havo dong and thc uniquc nature at tbs withdrawal éata.
Wt would raquost an exttnnion of tin» and will prcpnra a bud—
gattry extinct: should your tamuittuc feel that an extension
is feasible. 1 bcliavc that in eatansian to April 30, 1974.
would providn suffieitnt tint to carry out the final phat: at
this study.

�7.
mun;

mum-guru

.
-

m'm'm"m:m'rmww

H17"

.,.,,

.

.v‘..»mw-.g_\——

_V.W.Wm,

Dr. 3tl$h0n_881ra

.w wm—p

WNW“ .1 q-.ry_mwr,_. m."

m-m_-—.u “.-

13

~3—

.-u.-.~,..,ram—w

ﬁGthber

.m. :V‘erI-M'rww'

1973

Yrofousor Stefania tliICd on. administrativh problem
with mnﬁ~that of ch. duvaluntion of the dollar. At their
prestnt rate at uxpeaditurat, 1 d0 not anticipate that the
davaluation will altar ch. budget cignificnntly.

Sincnrely yours.
Max

en:

E.

J.

Gvadwcll

Fink.

M.D.

«w

.7

.-.—

a

A

v“

7,7 .rmw—

,—

�</text>
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                    <text>,.
.v.

._

...~..

-

(—7»

~&lt;—.~'v'a"_

73SB~756$B

13 Hovembor 1973

H. C. B. Danber. M.D., Ph.D.

Pro£cuoor of Psychiatry and Pharmacology

Callas. of

Modicino

Milli: Health Cantor
J.
Univlroity at Florida
H1111:

6:1nsnvillo. Florida

32601

Door Hy:

can to

York, I “locum! tho publications which
paychepharnooology from 1956 to 1967,
for
I felt were important
I am enclosing
of
psychopharnacology.
in
my course
a: part
no
an
v.11
additional
tho
an
of
group nines 1967.
a copy
reprints
when

I

Row

were to focus an I3 principal interact: in psycho~
pharmacology, the davnlopmant‘of quantitattvu EEG methods for
classification of drug: would have to be my principal contribu*
tion catamaran.~ From the voluao. you will no: curly papers
from this point of viaw, and sons of the later raprinto will
.

If I

bring the information

up

to data.

anothot point of View, I have always felt that con—
vulsivc therapy was a complex way of proviﬂina portintcnt bio»
dhaaicnl chanson in the brain for thoir boh:V1aro1 effacts.
2 In oncloaing a ﬂaw raprinto from :3 BOT axpcriuuco, particu~
ltrly tho cholinnraie hypothesis, for those may also bu tale»
van: for a rovicw of poychopharnacoloxy.
From

Finally, the'principtl focus of intoraot in How York has
boon tho duvelopnnnt of narcotic antagonists, and I am enclosing
a xnroxed copy of tho report whioh I pruparoé for the Marijuana
Commission in Soptoubar. 1972. This will 31?: you, I hops. an
overview of
My

mvwc

this spoaialized braaoh of psychopharmacology.

bust regardb.
signeruly yours.

.‘——-

'“W’mﬁt‘rry

:4». Pink,

um.

Professor of Psychiatry

‘mw

Noun

MF/cin

�</text>
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                    <text>7383-76388
Hovqnbor 14, 1973

Richard P. White, Ph.D.

Professor of Pharmacology
university of Tennessee Mbdical Unit:
Collega of again undieal Scianccn

800 Madison Avenue
Memphis, Tannassce 38103

Dad: Dick:
Yours is thn third letter I have rocaived since Labor Day
requcating recommandations for someona ta lead a department of

psychiatry.

Of the man working with an, no on» aeams sufficiently can
parienced or mature to accept such a resyonmibility at this tinn.
0f the man with whom I am cleanly associated, I know no one
who is uncomfortable or unhappy with his present job. with the
exceptions of Profcsnoru Ulntt and 1:11 of thn Uhiveruity of
Miasouri. You may not knaw that the Division of Mantal Euslzh
of that State has proscribed reaoareh in patient: at State ﬂI*
uticutianl. and both of that. fin: profonlorl have resigned in
protoct. I 69 not know uhathar Dr. Ilatt has another position.
but I do know that Profaaaor Itil is nagotiatinz with Dr. Alftad
Freedman of the New York Medical Collage. Both of thus: nan havu
lad axe-naivn program. of reaanrdh and have shown their ability

as catchers.

Good luck

in your search.

By

best regards,
Sincerely yours.
“RE, 1‘!va
m
Ptofclsor a! Plydhintry

HF/cis

‘
‘

,t
‘.‘

I
‘

Ytrwr

.‘mlﬁmlﬁm

-

�</text>
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                    <text>memwmw......W..,.

.w

7

.

______,..___

_.__.W

.V

I

“mm. W

E

E

7358~76153
14 Hovedbor 1973

G. Dolce. Man.

Mtdizinische Porschung/Pharmakologic
E. Metdk
61 Darmstadt

Frankfurter Straﬁo

250

GERMANY

Dun: Dr. Dulce:
;

I ranaivaa a note from Dr. Goldutcin that your trip to
ch: Unitod suntan has been dotcrrtd. I had looknd forward to

your
,

E

E

:

visit in

Havanbct.

I hope that you will have I chance to can. to the 3.5.
the
in
lprins, as Dr. Goldacetn auntiannd. and thus you will
than have tho 00333103 to viii: my laberatory.
my

bus: regards,
Sinantoly yours,
Max

fink.

M.D.

Ftofasaor of Psychiatry

K?/¢1s
ca: Dr. Leonid: Goldntcin

�</text>
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                    <text>.77."- ”Mr.

. ,..

,1,

w

.,-...

,.r....,.~mrv-rqq—Wr.m

"WW—“F.“-

"15.

.7”—

,_..

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_,-r

y.

,—

mdm

...v_7...w.~.__wvn .

.K .

-ﬁw.

7383-75933
1&amp;

Novonbor 1973

J. Roubiaok,

M.D.. D.8c.
3nd
Radical Rosoarch Division
Biological

Exporinontol Thoropoueieo Department
8nnﬁox, Ltd.
Ch-éOOZ

Boole

SWITZERLAKD

Door

Jiri:

Linda and Hichaol join an in thanking you for your many
kindnooooo during our visit to 33:11. Kot only was the visit
can that gave no professional excitounnt, for I an very much
impressed with your laboratory. but the opportunity to see
Basic and a pica. of France and Germany In wall was nos: ox~

consider the visit to the Boole
the high points of our trip.

citing to the children.

Musouu can of

We

If my visit was of coy help in orienting tho lttff at
Sande: to the potontialitien of quantitative EEG analysis.
than I will oonnidor the trip to have been most ouoeoosfol.
I an enclosing a capy of the announoonont of the ACE?
ﬂoating in Decombor. I look forward to oooing you at the

ﬂoating.
My

bout regards to Marcia and to your codworkors.

Sincerely yours,
Fink, M.D.
Profeoaor of Psychiatry

Max

Mir/c1.

Encl.

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                    <text>73SB~762$B
1A

Noveﬁber 1973

Professor Alfrod M. Fruednan
Department-of Psychiatry
Haw York Midical Colltge
Cahen Rnaaarch Building

106th Stroet and Fifth,Awanno

New

-

.
-

York, Raw York 10029

‘.
~v

m.

Baa: Al:

r-v1~,.vW-‘r"-W'1'v

my trip through Europe I had read the daily nnwsu
with
paputt
tropidttion; the wax in ltraal and scandals back
bout. the continued dsvaluation 9! ch. dallar, the 011 crisis.
and so many other horrendous stories seamed to fill the ptgaa.
As I want from Ron: to Istanbul. tha Iribuna currtnd the
story
at your Vilit to Russia. Whan I arrived-1n Athens, I found
tha
ulna story tn tho Athena H g. A: I hive lost tha Ttibuno aun~
nary. I an anclnsins that in tha Haws.

During

“'75

u

"'77,...WWWMV.

”_w,,._v...

‘1‘

‘

(wrr-Tzr

var

.
.

Jan»

r
._
w

._.._,-.,..-T.,._

«m

m-

-

m’l“$"'w'r4

I fnlt proud to be : monks: o! the APA and a number of
yaur staff. for it in rat. in this varlé—«which Icons so disw

houast and when: lenders Iona intcnt on calf—aggrandtsunant~~
to find that on: of my frinuds has apakan out. Thin was put»
titularly true bccanso, during my visits to Istanbul 1nd Athnnn.
I was imprinted by thc autistic: at Dru. Polvnn 0nd Stafaniu,
1nd their co-workors. Innnl 613 and others. that the United
Stntaa might net stand up to the Runnicn thrust. Since thc
Russian: rtptnuant tho principal threat to world peace today,
I an grateful that you and tho Association haw! spokan out
againat the abuts: of power that hnvu batons the hallmark;
of Run-inn thought and action.
My

thank. for your hanacty,
Sincaruly youth,
HI! Fink. ugh.

Professor of Psychiatry

HF/cia

Baal.

�</text>
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                    <text>n

w-uwu—MTINaran—wmwpw—nu—

-

~

u

,A

-...

cam-m

4“,..."

”7“. “JV“, .7 ,or,

.1....,..,W.,....,,,, w"
v

.m-v

r

..

..,.

.

-..... ,

n.7,," ‘r 17...“.

..&lt;..

.... , V......v.,._..o..r ,.

._n

73sn~76083
1a Rovonbor 1973

Charla; 0. Rutlodga. Ph.D.
Dopartnont of Yharnnoology
Univotolty of Colorado School of auditing
4300 East 9th Avenue
Denver. Colorado 80220
Boar Dr. Rutlndzo:

I ll planned to submit this letter of recommendation on
bdhalt of Carolyn V. Poiolor. who has worked with on since
Juno. 1972, following her graduation tron Colby Coll-go.
graduated with I major in biology and did eopc~
oially wall. but aha also to on without I specific toouo of
interest. This laboratory is dodtootod to the analysis of
tho changes produoud In tho scalp EEG of man by prolunod and
actlvl poyohonotivn agents. Th. facilition include Grass
polygraphs. FM tap. roootdoro. and a dodicotod IBM 1800 con—
onto: for data rcduction. Hi work with voluntonr waist to
ﬁxtondod obocrvatlon aoaoions.
Candy

Candy

has learnod

how

to interview voluotcoro. obtain a

analyst this quantitativoly aging all of the dot:
tuduction oqulpnont, and to nuunarlso and «walnuts tho data.
In addition to £36, oh. has loornod how to obtain Ilood can»
plan. take blood pressure. ond-noot 1mportant-to maintain
a profounionol attitude with subjects which inaptroo oonfidanco
and their cooperation dospito aioconfort.
fine

EEG,

This work has boon going on in my liberatory since 1959,
and Candy has been one of tho two most outstanding students
thnt I have had. Sho has always mnintalnad hot point, is moot
plea-oat to work with, is enthusiastic and completely roliablo.
.A

,

.
u:

'mm-‘m‘wwbmaruﬂr'fﬁ‘ﬂv

.;;.

Now—r

..

1

�mW—wwmw-Wﬁ.w.n‘wp.ww_.

Dr.

c. 0. Rutloégg

7w w mu“,-

-2-

,, ......,.. ..,.._._

,_

_

WW aw.

.

7—

._._ m. ,_»

V

7.

a... ..

16 Novonbor 1973

Horn 1: not for the fact
on to graduate eduottion.

that I onoourago my antistnnts to
I would rcgrot bar dociuion to
but
I
loava.
an gratifiné that the has seloccod n fins ins
stituuion in which to continua hot graduato studies.

I In ploasod to raconnnnﬂ bar without roaorvation for

go

you: graduate study program and hi»! assurod her tho: I would
b. dolishtod to havo hot toturn to work with no at any ttno.
Sincerely youru.
ﬂax Fink. M.D.

Professo: of Psychiatry

MF/oin

Encl.

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                    <text>7383~76358
Bovunbnr 14. 1973

Riehard P. White. Ph.D.

Profasaor of Pharmaaology
University of Tenness¢u~ﬂadical Units
Callaga of Basic Mbdicai Sciencas
800 Madison Awunue

Hemphia, Tennessee 38103

Dan: Dick:

is the third lattor I hava racaivnd since Labor Day
tuquesting reconmnndations for consume to lead a departmnnt of
Yours

psychiatry.

‘
m-

"’13

mwwm—

(«W‘rwurm

w.”

‘ZF‘S‘!’

rv'xmw-"an-wv

;‘_,,,:W~‘7W"llvwwwrWﬂwn,t‘!'ﬂ"-7“'U

0f the man wcrking with an. no can seams sufficicncly can
parianced or mature to accept sudh a rasponaihility tt this tiﬂﬂ.
Of the men with whom I am closuly associated, I knew no on:
who is uncamfortable or unhappy with his present job, with 2h.
axcaptiona af Prafastoru Elect and Itil of tha Univerlity of
Missouri. You may not know that thc Divisian of Mantel Honlnh
of that Statu has prescribed research in paticntn at State in—
stitutions. and both of thug: tin: professors haw: rcuisnnd in
protont. I do not know whethar Dr. lint: has naught: position.
but I do knnw that Frofessor 1:11 in nasatiatins with_Dr. A1130!
Pt¢odnan of the ﬂaw York Radical College. Both of this: man hawt
1nd extensive program: 6! ranalrdh tad havu shown their
ability
as tenchurn.
Good

J!

luck in ynur search.

My

best tqgnrds.
Sincerely yearn.

V
‘

rink. M.D.
Praia-nor of Psychiatry

Max

�</text>
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                    <text>wmlw‘mwm-‘me.vywrwﬂ,

..,~.,.._-V......,_..

V.r..,“,l___...._.w
V

._.V

-..,.

.

.n -w “w“. ﬁw ”ﬂaw"?

._

"ﬂ” 7.", .m.7,_

.7

.—w.v-mm,-m.—.

7333~76653

15 uevuﬁbcr 1973
/
..

.
Yr".

m...»

n“,1

q

‘ﬁv‘v-rvv

Charla.

C. Thomas.

Publisher

301-27 East Laurcnca Evan»:

Springfield. Illinois

6271?

.&lt;y—-Vu'm"

Act.: Oran: Dupartnanc

4

Guntlumnn:
,,,...‘V,‘._.‘«..,T,w.v.w~.mv-.

I

would

likn to otdor the following book:

L. E.

Holltntcx.

DEERE,

1973,

CLIHIGLL

883 OF PSYCHUTHERAPEUTIC

-u‘,...:vn—.;_.wm;r-

which I understand you puhlinh. A check for $6.95
Ylonaa ugnd ch. book ta an at the IhOV! addrcna.

-

3.70;".VNf‘

1: uncle-ad.

Thank you.

F—I’H'W'

alncorely yours.
mxmmn

me

Pink. M.D.
Profassnr of Psychiatry

Mix
wv-xvd'w-lm'

”a...

m...-

.W

-v-

-w-

"3-1qu

7
,

Hrlcil
E361 .

.._

�</text>
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w". .mv. ,_ w.“ ”m.

7333~76553

15 Navamber 1973

F. A. Davis Co.

1915 Arch Streak

Ph11¢dclph1a, Pa. 19103

Att.: Order anartuant
Gontlenon:

I

would

like the ordcr the following book:

P. K. Widnln (Ed.),

0!

which

GOODALB’s INTERPRETAIIOH

LﬁBORAIUI! TEST!

(7th 84.). 1973.

I understand you publiﬁh. A check for $12.50 13 onPlant. son&amp; the book to a. at uh: abova address.

closed.

Thank you.'

Sinccrnly yours,
Max

Pink. H.D.

yrofassar of Paydhiatry
H?/cis
Encl.

r“

�</text>
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15 ﬁovcmbcr 1973

Raven Frogs, Publisher15 Host 84th

Raw

Saran:

York. K.Y. 10024

thtlnlan:
Plans: send an

A

copy of the following beak:

May. Smith, tné Villnrcal (Edu.),
KAICOIIO AKTABGNISTS (Advaaetn 1n Biochalical

aruudc. Hattin.

&gt;

rsychopharnaaolagy 8).

W's-15""!

vv-prv

check to: $22.50 (eh. cttalogua print) is unclocod.
sand this book to an at the above nddrons.

A
"Viv"

Please

'.T“r‘v‘wy.rrm

Thank you.

stncaraly yours,

It’lwﬁvrvm‘

wwfrymi

HI! ﬂak, HOD.
Protester of Psychiatry

“mam“.

ywm‘

‘
1

”Mimi-”L

MP/cis

�</text>
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                    <text>73AP~768AP
15 Novunbar 1973

Donald

Elain,

M.D.. Troasurar

Annrican Psychoyathological Association, Inc.

Htllsida 30:91:31
Glen Oaks. new

Yomk

11004

Dear Don:

It 1: tr“. that one can buy and 3011 shnren of the thnan
Corporttion at thin 13 a elooadacné invescncn: trust-1t has
a limited number at churns outstanding which are sold on the
cpun market. Considnrin; tho dcbacla which has oceurrnd this
week, it may be prudoat ta 0.11 p‘rt of the charts now and ins
vast the profits at 8! in Treasury bills or 8.5! in government
bonds 0

I spoha to Mrs. Podrid this afternoon.‘ Sha told as chit
aha knaw of no probluna with the APPA program. Should you find
that. are any probleus, 91...: call no.
..,

Sincurely yours.

rnmruumrm,

"“7“

WV

”4

Max

3:,

m/cis
cc:

Dr.

J. Cole

Fink.

M.D.

�</text>
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                    <text>-w. a?

«J'vwc‘ncmn'mu—r—"v‘ ~--—u~w

—-

rum.“-

.‘.m

,

y

I&gt;&gt;vw’w ‘m— w.

v1.7..‘_w.,.,_.w.-. .

,w v.7- ,.

.. .

;

.

. ”.4“

,_ ..‘.....».,-.w

w... .v, ‘7',“ V...”

7333—77283
16 Hovnmbar 1973

subscription Bapatcnnut
Coggrohcnsive Pszchiatgz
111 Fifth Arcana
Haw Turk, ﬂew York 10003
Re:

Chang: of Addtaas

thtlcnmnzl
Plants change the addrtsa at which I racotva nggrnhansive

Puzchiatgz to:

Dapartmcnt of Psychiatry
Health Sciuncol Canter
3.3.R.Y. at stony Btook
stony Brook. 3.!. 11790.
Thank you.

Sinnernly yours,
Max

Fink, H.D.

Pratasncr of Psychiatry

Hr/cin

�</text>
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                    <text>7383—777AP

16 Novambcr 1973

Alberto DiMaocio, Ph.D.
Boston State Hospital
591 Horton Bttcot

Boston, Massachusetts 02125

Dear A1:

After I rcccived your

letter of

Octobor 2k indicating that

"wt cannot extend your invitation to Dr. Honk Van Riorcn.” I
called Jon Cole and than Dick Wittonborn to discuss tho content
of your letter. You must be aware that I became concerned about
two ocpctcte issues: first, whether the Secretary of the ACE?
or the Council of the ACNP have the privilege of rejecting an
icvitction by a Fellow and, second, the manna: in which you

notified no.
As

to the accond point, I understand you called my officc,
it was to discuss this mattcr with no. I trust

and perhaps

wuwutMrmwm

I havc road the Bylaws of the Association as well as the

memorandum of August 8. 1973. Nowhorc in the Bylaws nor in tho
August 8 monorcndum does
state the guidelinco to be used by

it

the Secretariat in rejecting invitations by Fellows. I believe
that your lettcr-cvon on bchclf of Council~~may he an arrosa~
tion of authority which may ho unjustificd. I say "may be" beccucc in youtcrday'u mail I roccivcd a memorandum from Dr. Wit—
tcnborn which may explain the attitude of Council but does not
justify the action of the sucrctcry. I need not remind you
that tho ACE? is fellowship of non intorcatcd in a common goal,
and tho invitation of a goon: usually rcflccta serious consider»
ction and should be givcn unusual «tight by the Fellow: and cc~

:

by tho sccrctcry. who. sitar all, acts to curve the
Fellowship. I undarstand that thorc will bc an opportunity to
discuss the question of inwitod guests at tho forthcoming coating.
and I intcnd to participate in that discussion.

pccially

Sincerely yours,
Fink. M.D.
Professor of Paychictry

Max

MF/cis

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                    <text>A.

"W"...

733B~77633

w:

—

16 November 1973
WW7-\I-

‘
"'1"

7—.-

.

Leo

w-wwuww

Hollister,

H.D.

Hospital
Palo Alto, California 95304

V.A.

mum:

Dear Leo:

‘

I have just tatutnad tram a visit ta Profuusar Stefania
at the University of Athens and have revieuud with him the

&lt;-

'
-V-

wrﬂ'aF'W‘ﬂ‘

‘4

Wynn-'3‘:

"‘HJH

-

data of our collaborative study, ”Chronic ﬂanhish Users in
Greece." This study has bean in proztuta for almost thtae
yaars. and we have limited cur presentation of data to tha
CIR? in Copenhagen and the ACE? meetings. I believe the data
demonattates some of the bizardu of long~term hashiah use, luv
eluding the development of tolornneo. Professor Stefania is
interacted in presenting this material at appropriate meetings.
I understand that you are organizing a symposium on drug abuse
for the 1974 CIKP meeting in Earis.
Shoal! 1: ha appropriate, ané consiatant with your da—
sizns for the meeting. perhaps you would consider inviting a
preaantation of these data at that meeting. I believe that
Dr. stafanis would want to make the preacutation. whieh would
be co~authored by son. of the investigators from the United
States and Athcna.

w

-.

«2m,mqv&gt;m,-.wn

my

best tcaurda,
Sinceraly yours,

gar.

’
w

Mia:

unk, mu.

ProietnOt of Psychiatry
MF/cia

cc: 0. Stat-nia
5.

Start

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                    <text>7383*778AP
16 November 1973

J.

R.

Wittenborn. Fh.D., Prasidont

American College of Heuropsyohopharmacalogy

Intcrdinciplinary Research Center

Rutgers Univuraity
Brunswick, Row Jersey 08903

How

Dear Dick:

First, I want to thank you for your cooperation in raw
solving the issue of my invitation to Dr. Bonk Van Riozcn.
I hnvu road you: memorandum of Novanbar 6, and I an
writing to respond to this. The issue» strike on: the
bylaws and present policies of the fellowship; and the nnnd
v~ns pictured by Councilw-for additional inconn.

.w

-

-

TJLW“§IU"H’"'W‘WW

Vmﬁt

".va

'ijﬁl'".

7’”r:’w'

In the early yaars of the ACHP, when it was decided to
hoop the wasting: small. tho 3ellowa votod to limit the nun—
ber of nodbers. and in snooooding your: rantrictad the invi~
cation of sonata to one per Follow. I cannot recall, and in
checking the bylaws cannot find, any stipulation as to who
may be invited. The assumption has always boon that the Pal“
low inviting a goon: would do so for the purpose of expanding
the participation in tho activitioa at the ousting. For cx~
topic. I havu invited co~workorn as sonata when I thought that
'ihayocoold contribute to the sessions or when I thought it
would help thoit education. I have also invited proopactivo
numbers. and in the past your: invited foreign collaborating
aoiqntists because I have vinhcd to encourage a broads: pnt~
ticipntion by the Fellows and laboratotios not represented
in this country. Indeed. Torah Itil, Martin ﬁsts. and I have
carriad this mission to for that no have invited 1 number of

toroixn scientists who how: no affiliation in this country
to participato in on‘gghhg§_nnoting nan: month.

�J.

R. Wittenbotg_

~2¢

'16 Novomber 1973

In this regard, I boliovo it is an undue assumption of
authority for the ﬁectotary, the Pro-ident, or even the Coun~
oil to rejoct an invitation extendod by 3 Follow. whether
Follows should or should not invite snout: to tho 1974 matting
could be toilod next month. If the docioion is made that
sonata are to be invited, it is clearly oath FelloWéo prth
logo to invito whomnvot he planets. and i would hope the Fo1~
laws would not dnlogoto a voto pout: to any officer or to
Council, but would trust tho good judgnont of each Follow.

issue, that of the need of tho Ann? for ad—
ditional funds, is one that should bu diocualed by the Council
and tho followohip next month. I think it is donooning for tho
ACE? to not a quota or levy a tax on industry. should tho ans?
really nood funds for niooions that are in the public interact,
a description of the miouion, a call to the fﬁllowohip with a
oonourroot latter cont through the followohip to indultry,
would probably bring a voluntary reopens. consistent with the
on. to Which the funds would be out. A: it is now, neither
the fellowship not industry has been presented with a clan:
otatoment as to how the funds are Spout. True, there is a
financial report at oath ﬂoating, but this is gloosod over.
Indeed! my tooollection is that the AER? has almost $50,000
iniita trouury. (At the lat nation, I won stmek by the
oboorvntion that tho ACE? was tho secondwrichest organisation
to which I bolong.)
In driving to work yontorday warning, I listened to o
toplay of the Sonata Watergate hanrings. in which tho.Prosi—
dent of Anorioan Airlines indicated the prostate that Mr.
Hixon's lawyer! placed on induotty. Rofleoting on his a:—
ooeintos sad thoir ottionn. I felt those to be immoral, if
not illogol. To what extent would a policy of a molti~thou~
sand-dollar tutti! {or industry to participate in on odocnw
tionol «noting such as out: be tonsiderod of borderlino moth
The oooond

._

..

.
.

.‘.,.,.,.

{“1"

o

,W-‘,._.Hlm.um.

A...

..

2'11""

ality?
I an

to discuss tho policy of abstaing high moor
berohip foe: to 0.8. industry rootstontntivoo. I should like

the Councilla vicwo.to be discusood by tho fellowship with the
viaw that the policy be changed. I holiove that the ASH? will
be on titan: othical and fionocial grounds it participation in
the auctions is separated from the inane: of fund raising add
expenditures.
.

Sincerely yours,

.""

'-

Wluixnwrr:w=rvx’v‘r

Max

';

rink.

M.D.

Protoaoor of Payohintry

V"

.pz‘mwwvw

pnoporod

Hr/tis

�</text>
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                    <text>7383~773$E
16 November 1973

Dr. Karl Pribram
Departs-at of Psychology

Stantord Univoroity
Palo Alto, Colilornio

9&amp;305

Door Karl:

ins.

It was kind of you to not aside soon time on Tuosday uoru~
Doooubor 4, at 9:00 a.u. for Dr. Honk Von Rioaon ond lynolf.
I

hovo knowo

9:.

Van

Elston for three years.

He

in Chiof

Photonoologist in the soiautifio Dovolopmtnt Group of H.V.
Organou in Holland. This company has boon intoroatod in hor—
monoo for unto thou 56 yolro. Undo: the stimulation of Pro»
tensor David De Wind of the Univoroicy of Uttooht, Dr. Van
Riosco and his oo~workoxu havo otudiod the offoots of polypoptidos on brain function in o variety of conditioning pora~
dials. They how: noted that loan of tho ooptidos 30C. to prov
coco tho animal from unwary loos oocoaionod by coz~ or gluon
trioallywinduood ooiauroo.
Dr. Van Bianca in attending tho Aﬁﬂ? ﬂoating: in California.
in intorootod in mooring you to discuss soon thaorociool quoo«
ciao: conoorning nnmory and brain function sad the possible signiliounoo of hormonal influonooo. no specifically aokod to woo:
you on wall as Jim Koﬂough. Ho will ho visiting Jim on Friday
He

and

2:3'Saturday.
I am pleased to oocoupany Dr. Von Rioxen. as this will give
no tho opportunity to visit the Stnnford campus, where my son
ontollod on a stoduoto student in zoology in Soptonbot. Tito
will be ay first oooaoion to 388 hi: and to Vinit-hio dopattmont.
Should he wish it, I may rat: the liborty of bringing him along,

as ho opporoncly ottoodod ono of your looturoo rooontly and wrote
no of his favorahlo impressions.
Thanks again

for letting said. the timo.
‘

Sinooroly yours.
Flak, 3.9.
Professor of Psychiatry

Max

Mrlcio

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                    <text>73AP~771AP

16 November 1973

Joseph Zubin. Ph.D.
Chief of Psychiatric Reeearch (Biometrics)
State of How York Department of Mental Hygiene
772 West 168 Street
new York. New York 10032

Dear Joe:

I

am

delighted that the voluna Contemporary Sexual Behavior

in in such demand. Your optimism in reprinting 2000 additional
copies is commondeble and. onee egein. I think your vision has

been substantiated.

I called Milt Greenblatt and was satisfied that the Com~
mittee had made an appropriate recomnendation with regard to
Philip May. A copy of Milt's note to we is enclosed, and I
believe that the View expreeeed in this letter abould be made
a aetter of APPA record. I plan to raise this in the discus—
sion at the next Council-aeeting.
Again.

voluae.

my

congratulations on the success of the "eex"
Sincerely yours.
M“ Fink,

MF/cie

he}. 0

Md).

�</text>
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                  <elementText elementTextId="106812">
                    <text>w. .VVv—vr-

- .

a

.w'

,-

_,_ awr&lt; n .-..,..__-..-.-—w..—..-~v._...

.—

, ~...v.....r.....-,_.,— Hwy“. , rm.
.

.

Y

N..- ..

,

w

r.

"m...“w

.u.

Vuﬂq..w.

.,, V, o.

73S3—779SB

16 Rovambcr 1973

Barrett Booville,

M.D.

Division of Nourophnrnacolozy
Food and Drug Administration
5600

Fisher's

Lana

Rookvillo. Maryland 20852
no:
Door Dr.

Haltroxono IRE

Scoville:

I

on writing 13 response to a tolcphouo call from Do. Alon
of tho Rational Instituto 0! Mental anlth. who indi—
cated thnt chore night b. noun disuatisfaction with our IHD
submission for tho uvaluation of nalcroxnno. Dr. Ramsey raised
a samba: of questions. and in the lbocnco 0! clear inquirioa
from your offica but anticipating that than. quootions are
sermons, on at. submitting the following addendo to our sdb«
miosioa of Sopteubor 1‘, 1973.
Romany

1.

Eviﬂcnco of not of opiates for a minimum period
of on. your and at loos: two prior attempts at
discontinuation of drug non will b: proraquinitaa
to adoinatoo to tho program.

Incronanto will follow the

latest information

available. which at prunout ouggonto the ottoty
of 20 a; incromnnts to 100 us 9:: day.
other nnrooaic antagonist will be used as a
control.

3.

No

4.

A

copy of the cousin: form now

in nos 1: attaohed.

“7,-

�v...,.A

u“«r&lt;

w..-

w-u-vru

,-

'I",'

-—.-u-~-n&lt;‘..m.

”1-,...

_, nv- ...... u—m‘ luv—“n... -1...

B¢rruet Scavillo, H.D.
5.

6.

~2-

“w“...w—rr'rnmq.‘

,7

n-

.

,

,

‘

.

16 Hovulbar 1973

This project was approvhd by two

institu~

cional caviar enunittcas. that of the V33
Rorthport, datad June 11. 1973, and the
003138 of 5.U.R.Y. at stony Brook.

urinalysis are cerucnnd in all patient. on
an irregular basis. averaging twica a nick

during tho

first

two months of «valuation

and trcscnuat and weakly
7.

,,,_ .-~-

we

thereafter.

are aware of no svidcnce rcquirina a

op¢~

cial aphthalnolasical attainaaion eithar

be~

fora, during, or littr drug trial. Should
thin ha mandated by the FDA, wt tequnst the
Justitiaation for such unndatc bu suba¢ttod,
for eumpllanca with thin suggestion is Orv

pcnsive and difﬁicult.

Sincerely yours.
Mu Fink,

Hob:

rrofosaor of Psychiatry

HF/cin

Encl.

.

�</text>
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any-ya."

or
n

73AP~767AP

'wwmm-W‘

-

-

NW?

16 Rovodbot 1973

‘W-xr‘

'm‘.

(ﬁn-m»

Jonathan 0. Coin, M.D., Secretary
Anorioan Psychopathologicol Aaaociation, Inc.
Tomplo

Univoraity

Philadelphia, Pennsylvania 19122
'W‘W'WMMW

Baa: Jon:
Tho minutes are ooaantially correct. Since Lowrance Kulia
has died. I have delotol our raconmandation from tho paragraph
on Page 1.

“MEIER"?

Wm

1

Wmm’m’

I have

aakod Fritz Froihon to that: and Joe Zubin and Sam
be
on the Nominating Committaa for 197&amp;. This amendto
ho
addad to tho minutes of Octobar 15. I agree that
uoot might
both Milt Grocnblatt and Mt. Goollnor bo invitad to tho March 6
Council looting. Invitations to Spitacz and Freihan also would
be appropriate.
Guaa

I am also enclosing a copy of a letter that I hava received
from aux: Grenoblatt following our diacuoaion of tho Roch award.
beliovo the latter to self—explanatory and supports tho Com~

Inittaa'a
‘7‘»?

.ieuzwrmﬂwmmﬂwwmm

rocounandation.

Thank you for your help with tho ACNP invitation. I was
able to clear tho invitation for Dr. Van Riozon with Dick on
tho balls that Van Elston to a Iotaisn pharmacologiot. I trout
you will havo a chance to coat his in California. Ho hawo a
date with Lyla Hillar for Novoﬁbor 27.

Sinearely yours,
:4"

ﬁsh:

Hhx

n—xmra

H
95“

at
77-22).?

...v.

ﬁllets

Ennis.

Fink, H.D.

�</text>
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                    <text>..‘

”My“,

(r
.

”aw.“

V

V

u“

w.»

w. -....»_.w..——..t_wwv...r.—.../......—.,»

ur.“lr-~‘an!~‘.v‘v&gt;vn .0.

mu

7

,.

-

. Hay—rm“ awn—"q... .,‘,,

v...“

_

v

7333-77653
16 Rovoubor 1973

Leo

V.A.

Kolliotor,
Hospital

H.D.

Palo Alto, California 9&amp;304

Door Leo:

I box. just roturnod from a visit to Professor Stefania
ot the University of Athens and hero roviowod with him the
data of our collaborative study, "Chronic Hoohish Users in
Greece." This stuoy hos boon in progress for almost three
our presentation of data to the
years. and an hove limited ACE?
ana
CIR? in Copenhagen
mootinan. I bolievo the data
the

demonstratos some of tho hazards of loog~torm hashinh use, in—
cluding the developunnt of tolerance. Protease: Stefania is

interested in prooentina this material at appropriate nootings.
I understand that you are organizing a symposium on drug abuse
for the 197k CIR? mooting in Paris.
Shoal! it ho appropriate, and consistent with your dooizns for the mooting, perhaps you would consider inviting a
presentation of theoo data at that meeting. I holiovo that
Dr. Stefania would want to make tho presentation, which would
b. oo-authored by tom. of tho inmostigotors from the United
Status ané Athens.

,2

,

My

.4

”mm

boot regards.
Sincerely yours,

no,“

,

mar“.

”I;

piﬁk, Nob.
Proton-or of Poychiatry

uwwrﬁwwq.rﬁwn—r~.u

MF/cia

co:

C.

Stefania

5. Stars

�</text>
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                    <text>73619-4 70A?

16

Milton Gambian.
V.A. Boopital

Hoveﬁbor 1973

24.1}.

Sepulvcda, California 91363

Re:

Dear H112:

665/116. 10/26/73

Thank you for your daacription of the Paul Book Award.
baliove
the paragraph apall out an approach which is comI
nondahla and which I will auppott at the forthcoming Council
mung.- shots“ it b. poaaiblo, I would ha grateful if you
would attend the Council meeting so that this morondua can
be mda a nutter of Association rooorday
Many

thanka

for

your recommendation.

Sincerely youra ,
Max

PIP/(:13

Fink,

14.1).

�</text>
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.

w ......
.. ..7..wywrm.ra—__....,—,\.w.-.‘;(._.q___.wv_

w‘v—y...-\.._

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w.

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h. ....."._..

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n“

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my," ..

-nm—

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7BSB~77583

'4ruwwn’1

'y"wﬂ4"5"'-WJW‘A'&gt;'

16 ﬁavuﬂbor 1973
"Harv

I
I"

r
3“"

,

'.I""T‘r'

W

vuau rum.

3.».

Alan Corporation
950 Past M111 Enid

Pale Alto. Ctlifornin

9&amp;304

Dear Virgil:

llplln to

visit my

son, a graduate laudtnt in the antrt~
at ananford University. on Monday. Dgcudber 3.
I will Eek. tha libatty of calling your office in the morning
in the hope that it would by possible for an to 3.: coauther
for a chat sous tins ﬁurins Eh. day.

man: of Ecology

‘I‘.

My

‘mg-u.

has: rugsxaa,
Stnanrely yaurs.
Max

Fink.

“.9.

Profcssor of Paychiacry

MF/cin

-m

i

am,

v

.._.

,

-77

�</text>
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                    <text>,, "w

Mm",

”wan-n. ..-.

V

“.15... ‘3wmwmm3v-yh-y‘nww.h”7; .m .._. v

.fiwrvyn—rm—J-nnm

—..~

._...a—h———w-—s—Wu

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-

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..

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n

~

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v.7

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7383~78083

19 Huvamber

1973

wry

'
:0

-ruywn':mm1v.mvs

.

M B H

0

R A

H D U H

To:

Hr. Jurgnn Krnuﬁc. Associate Ditcctor of Personnal

From :

Max

Subject:

Tuition Waiver for Peta:

Fink. M.D., Profnsoor
M.

Irwin, Spring 197k

Encloscd plans. find the Tuition Haivnr form for Pater
Irwin. Mr. Irwin in ruspansiblo for extannive data manly...
gauorncoi by our ongoing psychiatric cvuluations. 30 use:

facilities on campus for thi: work, and he £ta~
it unca-sary to modify programs and sclcet up.
propriata ctatistical procuduxcn. His atudics in computer

cha computer

quantly find.

at. ditcetly rclated to his work in this departmant
will unable him to pattern his dutica in a morn sophisti~

sciences
and

cared Ind preciac manner.
Your prompt

MF/cis

Encl.

attention in this mattcr will

bu apvreciatcd.

,

�</text>
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                    <text>‘m\--,-vrav-rm'

.

.n [nu-n 1r,

J." _.”,,,N(W.W,.m.,.,_..

»

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W_«‘.‘,;A,.;.‘u,mm,...d

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-

.

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1

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Ir

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7383~78233

7
W

v:

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.

26 Eavnmbor 1973
.Wuummavwm.wum

Dr. Alan Ramsay

Cantor for Studies of

W

-nr‘u,'rw‘-x

emu-w.

mow-7

&lt;

2;

Hg.

—1.,.V1»—rﬁdyl-.'Ww

r&lt;.v~q-’”r,'6.l

In

.~

&lt;v“

'1'?

“Fm"vm

nanny-q-

Rarcotico and Drug Abusa

Estional Insticuca of
5600 Fisher’s Lane

Muncgl H¢alth

Rockvilla. Maryland 20852

Dear Dr. Ramsey:

Enclosed is t dppy of tha IND #10095. which was apora~
tioaal for our study of naltraxona.
havu alrngdy answtrud tho questiana on Page 1 and will,
within 2h: suidolinas of our study. make every effort to abidby the suggestions on Page 2.
Wt

request an initisl supply of nnltrexonc,hydrochlor1dc
syrup of appraxinataly 1.5 grams, which will nxgnw us to treat
ftvu patiantn for 30 days. with an avatage dese of 100 mg pa:
day.
we

“ﬂaw-m

Sincerely yours.
Max

Fink, M.D.

Professor of Psychiatry

MF/cia

Baal.

w

-

:x-

----

«w-

~ Av

av

u.

:vrn-

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�</text>
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7383~787SB
26 ﬁavaubcr 1973

subtcription Dupartunnt
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DEPARTMENT OF PSYCHIATII
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8.9.N.Y. AI $10!? 3390K
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Sinatraly,
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Profculor of Psychiatry

Mllcts

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7385~78888

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H E H O R A E

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Pink. H.D., Profonsot of Psychiatry

from:

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                <elementTextContainer>
                  <elementText elementTextId="106806">
                    <text>WW“ ”r"

w.

. --~11.--.—_.-’n,:'.9’rwr'",[W"

-

'-

m.

- -'

""I-xmm‘v'“

auwwnmmmamvzmwr‘wm

~

"NJ-IV,”

Mr ‘r'r

«Tr .mrv unsavrw

; -~-~-‘-

r7: 'vwvv- .‘gw—wr“?ﬂ'g w". “WW9”.

”TY“

73$B~79ZSB

28 November 1973

Bernd Saletu, M.D.

Missouri Institute of Psychiatry

Street
St. Louis. Missouri
5400 Arsenal

63139

Dear Dr. Salctu:
which

thanks for sanding as can. of your rocnnt
found most interacting and halpful.
have
I

my

concerned with aha and cvonts
occurring in Missouri. I crux: that it will be possible for
Dr. Itil to continue his prograa in Raw York, and I hope :htt
you will find the occasion to visit me and him when next you
come to New York.
As

y‘wmmw

mam

mu

I

reprints,

I

you must know,

am

am mndh

writing also to ask that

recoré from the

How

you change
Yerk undical Collsaa to:

my

address of

mv

Departuant of Psychiatry

school of

r—uwrw.mw

Health Sciences Ccntar
S.U.N.Y. at stony Brook
Stony stock, New York 11790.

,

”renew-Mum:

Mn§1c1n¢

My

...

best razardn to your wife.
Sincerely yours.

11

Var/VHWW

Max

A

W

w-wx.mwvvxw~mn~gmn~u

—-

"v

Fink,

M.D.

rrofausor of Psychiatry

cr-w-vwm-as-u-w-«ww

Mfleis

3.5....

. . .3

�</text>
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.p

Annammhwwu

.

.-

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E

,i

I
,F

.-

_.,

nunum" whim—m

w‘wmmw“

,

_

F'Www‘ww‘m-“mr‘

a]

-

ww-

,

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xv:-.

.m-m

,

,

W:

7333~78953
28 Hovuﬂbcr 1973
Dr. Lyle K.

Hillcr

Sankara Pannsilvania Psychiatric
Philadalphia. Ponnnylvania 19129

Institute

Dear Lyla:

I want to thank you for spending so much tin. with Rank
:nd myaclf yesterddy. I found the V131: valuubla in helping
us to undaratand ch: studies which you havm dun: during the
past

few

years.

I read the draft of the taper: of the atudino of acru a~10
1: uttnizhtlorward and have two
on ch: way home. I think
ouggcctionl. 0n the batten of Pan: 1, max: to the lane 1135,
should rnad ACTK 5~10 rathct than kCTH 1~10; and on Eng. 3 ch.
mathod of Experiment 2 could be clearer
tho ward "intra—
venous” were added nonuvhqru in thc mathod.

it

it

Conaidnring the nuﬁbar of variables which havs been teatad,
Benton taut might
have occurred by chancn? In 1: not this 1::un-«and, perhaps, aa
undarstanding of how it cana about—~that should be ch. focus of
a ouccaading study?

is it not poaaibln that ab. diffuroneu in ch.

A331n.

Dr‘cory

my

thanks for the Opportunity to

viait

your 1ab~

o

Sinceruly yours.
Fink, M.D.
Professor of Psychiatry

Max

HP/cia

�</text>
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.p

Annammhwwu

.

.-

ﬂunk,”

E

,i

I
,F

.-

_.,

nunum" whim—m

w‘wmmw“

,

_

F'Www‘ww‘m-“mr‘

a]

-

ww-

,

,

xv:-.

.m-m

,

,

W:

7333~78953
28 Hovuﬂbcr 1973
Dr. Lyle K.

Hillcr

Sankara Pannsilvania Psychiatric
Philadalphia. Ponnnylvania 19129

Institute

Dear Lyla:

I want to thank you for spending so much tin. with Rank
:nd myaclf yesterddy. I found the V131: valuubla in helping
us to undaratand ch: studies which you havm dun: during the
past

few

years.

I read the draft of the taper: of the atudino of acru a~10
1: uttnizhtlorward and have two
on ch: way home. I think
ouggcctionl. 0n the batten of Pan: 1, max: to the lane 1135,
should rnad ACTK 5~10 rathct than kCTH 1~10; and on Eng. 3 ch.
mathod of Experiment 2 could be clearer
tho ward "intra—
venous” were added nonuvhqru in thc mathod.

it

it

Conaidnring the nuﬁbar of variables which havs been teatad,
Benton taut might
have occurred by chancn? In 1: not this 1::un-«and, perhaps, aa
undarstanding of how it cana about—~that should be ch. focus of
a ouccaading study?

is it not poaaibln that ab. diffuroneu in ch.

A331n.

Dr‘cory

my

thanks for the Opportunity to

viait

your 1ab~

o

Sinceruly yours.
Fink, M.D.
Professor of Psychiatry

Max

HP/cia

�</text>
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                  <elementText elementTextId="106805">
                    <text>:V-v-yer-y‘w.“ ,w

..

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,

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7353~79OSB
28 Rovenbet 1973
C. James

Klett.

Chief, Central

Ph.D.

RP

Research Laboratory

endeooperetive Studies Program Support Center
Veterene Aduiniettetion Hospital
Petty Point, Maryland 21902
Re:

‘73:!"

&lt;

Gel/151$, 11/23/73

Beer Jim:
«I

"WW-“1

‘me.a'-p:~

—

.mnr

I received your letter

on Hocdey describing the agenda

for the Rev Orlecne meeting. I had diecueeed with Dr. Swanson
his participation at the eeeting, and he is prepared to pet~
tioipate in-the eeeeione end to provide dete from our project.
I

am

unable to attend the eeesion en

at the University on
Orleans until niddey

schedule.

it 18 not
on Toeedey with the

Monday and

we

have a

site visit

tea:ib1e.to reach
prevailing flight

ﬂew

ea pustled by one queetioo which you may be able to
At the meeting in Denver. the question
of the examination of EEG records we: raised. Coneidetins
the limited availability of facilities capable of quantifying
Inch detc, I offered to monitor each a study and to mike the
facilities at Stony Brook eveilehle. I hove written to the
investigators. discussed the propoeele with Bra. Cantor end
Ling. end proposed on two occasions both the budget and the
first phase of such e project. I have received e tape from
Dr. Lins'e cowworker.‘Dt. Barbara Brown. and have reported to
them thet their equipment in fully ooupetible with our system.
1

raise et the meeting.

-

&lt;

vva

w~mw,vvv—v

u’mﬂ,-‘

v

rv.r~r1—'1.'-

-;-

Iva—WP."

'WWN‘"

vmm‘m'm'wﬁ‘vnw

mun—mum

However, since I have not received any official notice
togetaina the statue of these proposals. perhaps it would be
appropriate for either the Executive Committee, the Operation:

�cumin“.
nnd

or Dru. Rum and Cantor to walnut: tbs
proud. some «anion rant-ding ch. proposal.

amazin-

811:“:on years,
rink, 11.1).
trot-«nor a! Payehutry
Hut

urinals
ca: 311th Ling,

14.1).

�</text>
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                    <text>_H.

A.

,

.VVWTWN...

.A.

..
A

.viv'rr-Mn—Av

-.

.

.wwmqup—gyw-xww

-»-

7383-79483
28 Novembor 1973

Robert 3. Robinson. M.D.

Houropharmaoology Suction
A. 1!. Robin: Company

1407-Cumoinsn Drive
Richmond, Virginia 23220
Dear Dr. Robinson:

I havo just rotnrnod from a trip to Europe and boon tovieuod your lotto: regarding tho EKG chanson associatod with
lonporono (Aan2277). I do not know how to interprot the
data prooontod banana. we have bocono ocouotonnd to finding
ouch EKG changes with many of tho anti-psychotic compounds.

your: ago Dr. Itil and I become oonoernod with this quoo~
tion and in a oyotonotic study o‘ thioridnsinn and chlordinso—
potion oolloctod the out. carefully and had then ovaluntod by
two interniuto. Wu worn inpronand that the EEG ohongos induced
by thioridanino wore significantly groator than those induced
by chlozdiaxopoxido. In a oooond study. patients receiving
fluphonozino. thiothixono. and haloporidol wore examined for
EKG offoots.
In this study. the group of patients had favor
EKG changes than the patients who had rocoivod thioridnxino.
Sinco than I have followod the literature carofnlly and note
tho studios of Ban and Lebanon, Gallant. and Simpson. Each
of that: author: has indiontod that tho EKG changoo following
thioridnnino worn much groatot than othor anti-psychotic dross.
Bonn

it

When looperono cons: to Phase III touting,
tight be
odvioablo for you to connider a direct comparison of its cardio»

vascular affects with tbioridasino and one other anti~poyohotio
compound.

with razord to out own work. our doses are much smaller

and we

anticipate

no

direct outdio-vooculnr difficulty. I
this to my attention.

thank you, however, for bringing

-1-

�,WW-‘Yq‘
'7

..

‘

E. E. Robinson. K.D.

28 Havanbnt 1973

*Zw

Rt have continnad our doaa~£1nd1ns studio: and
now
looking with stutter detail at ch. EEG tad behavioralarteffects
of 3 and 6 as domes.
My

bust regards.
Sinaotcly yours,
Max

rink,

H.D.

Professor of rlychiutry

MF/cts

�</text>
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                    <text>7383~7QTSB
29 November

v

1973

V'-

.wmmm—

'1

”I-l'r

A131:

611...

H. D.

Hndical Dcvulopucnt Group
H.V. Organan

08:

HOLLAﬂD

Dear Alan:

flurry of telegrlns, the luau: may still be nu—
am
I
In
writing to luunnrlau our prasonz Vitus on ch:
clear.
63‘9‘ 'tmo
With the

Aikl will be arty for thc not: ten days, I will deter
until ald-Dccunbar two GB~9§ utudiot in “blah we will admin»
into: 2.5 as at 3 as GB~9¢. Vb will collcca blood staples
tollawing eh: :ugscatud protocol, fraaua :ham, and ship than
to you in Holland by air .upttlc. I will Tole: arrival in—
fornntlon wall in advance. WI vauld llk that thc chawiats
aaocno

than: nanplna

and

usable and whathtr.63~94

tell

is in

an whatnot chm

3.391.. are

unaunzabla amounts.

Based on ch... data. w. plan to undnrtako an EEG study
with blood nuasutunnnta at 5 IE or posuibly 2.5 we donut.
Rncogniaing ch. difficulty in providing aauplou that look
allkn, an haw: toquaatod eapsulcs of 2.5 I; GB~9A and 5 as

audtriptylnnn. With matching placdbo aapuuloc. u. should
bu able to dallvur nlﬁhsr 3 or 6 cap-ulna to a uubjuet,
making up :ha dltforcnes b¢tv¢¢n ehc tOEIVi dose and total
uuub-r of egpoules by a placcba capoula. we ask for 5 a;
taltriptylonn banana: u. think that 15 n5 is an :daquato and
safe 603.33.

�‘

,

«wk-1.“,

wwwv—gnwu—vv—m

1-w---~W,Awuwv~

"'"1‘1'

‘w—V‘

x

law-”4‘ wan-a-

.

-rs

.va—-

a

«raw

Alan GileqlAK.D.

..—

:

,

~

"VVWW'WWJ-wh-wr

,

«2-

"7x"‘!~.‘.mr7wr .WWI-‘Q-m.‘ 4mmW4‘tV—,‘y—wwma-v ~

29 November 1973

than not be available in mid-- or late January
anticipate the atudy can start, then we will gladly

Should

what: I
ace-apt:

the 2.5

mtriptylam

of

I; 03-94 tablets and the 10
with matching gumbo.

In either instance.

main

we would 11k!»

to

drug and 200 units of placebo.

mg

but

tablets of

100 unit:- catch

jht

had an manning trip vith ﬁnal: to PhilaI haw
delphia and 10‘; toward to noting him in tale Alto for waits
to California ind Em Orleans.

but

My

”glitch,

.

Binccmly yours,

1m

rm.

11.9.

Professor at Psychiatry

Erich

'

‘Iwmmwnqmpux

..

.

v

‘

"N.

.

�</text>
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                    <text>v—n‘n’w‘

m
&lt;

711-7981

29

Navrabcr 1973

Euviro Syuta-l Survica Corp.
9

Shirley

Bohnnin.

StIOOt
York 11716

Haw

Gantltuan:
Thus.

bills

tn ah. Earth

rcachcd up aftur Iona ﬁning and rcflnct charsaa
and Spice Sciuncaa installations. Us haw. no :0—
for than. and um would nuagtut that you submit

sponnihility
that. to th. propor dopartnunt.

Th: sultannnt of Deedbat 31 earrint. in addition to that.
threc charges, two ¢h3x3¢s dacod 8/24/73 and 8/30/?3. If my
rocollcction £3 entrant. w0~2778 was ruturrud to J 8 E bncauno
I felt that thin uh. under ch: fixstryoar warranty. If tut: to
innorracz. 91.13; uubnit a tetra-nut with aha Approval of J i E
for payucnt.
a charge for can haunt of filtcri uhiah an had
indicatad anrliar vurn oxeacaivu for our used: an&amp; which wt had
rgfuscd at In narlinr data. At can: paint than. ﬂute shipped
again. not following our zuquunt. Hy anal-tnnt, Mr. Irvin.
aallad your attic. to indiaatc that at had obttinnd an adc~
aunts supply at filter. throngh bid: ‘t n lava: can: and that
BO—28‘9 13

this shipuont should be pickad up.

$1ncar¢1y yours,

NI: Vink.

ass/m
ﬁnal. .

M.D.

�</text>
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                    <text>“V..."Www.’

("Y—w.

-T.~:-_V~V.

“WV—«Wavymn—q—‘m. ._, ....r

,V

V

.

-

.

..

‘

,

-

v

w.

vymzwwr -

v'~“v.

1!‘¢'IWT‘”'|""“:‘unemnr

”3...»—

wr-mr-'rr‘:“rut-ﬂ!

'hwrl

7BSB~79683
29 November 1973

Dr. J. Silvio
Clinical Drug Scudina Suction

Rational Institute
Drug Abuse
National lnstituta o Mantel Knalﬁb
5600

Fisher's

Lana

Rockville. Maryland 29852

silvio:
Enclosed is a quarterly report of activities undar

Dnar Dr.

tract

Ho. HSM—é2~73-260

cobnr 31, 1973.

for the period July 1,

Con~'
1973, to De»

for naltroxona (No. 10095) and
requesting an initial supply of
naltrexonn of approximately 1.5 grams, which vill allow us
to trant five patients for 30 days at an average dose of
100 as par day.

haw!

Wt

have obtained an

wriitan to Dr.

IND

Ramsay

On acrobat 15, V! requasted permission to transfer the
can of $475 from 8.8. Traval to Foreign Travel under this
comatact to permit our ruprnsuntation at the Nncqus Cone
mitten on Problaus of Drug Dcpondance meeting at Maniac City,
“arch 11-14, 1974. I had writtun to Dr. Ramsey about this
prior to your uppoincunnt as Yrojecc Officer. I would bu

grateful

if

you would

precast this request.

I look forward to wasting you.
Sincerely yours.

rink, M.D.
Protease: of Psychintry

Mn:

HF/cio
Encl.
cc: D. 2. Charlton

W, eat-v.“ own. r :v
‘

�</text>
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                    <text>-

‘
um

.n

.Y,

-

'iawm'Iw-YrTJWYV‘uvI

73SB~799SB
30 November 1973
M

E M O R A N D U H

To:

Sherman N.

Prom:

Hex

Fink,

Kieffer,

M.D.

M.D.

Subject: Grant Pr0p0881-Pagal

3B~C-D

conceived of the central office staff and the University
as "supporting perooonel." As the overall director, we
envisaged you needing two coordinators. The associate profes—
We

staff

sor/director (helf~tine) ie responsible for the clinical aspects
of the progrema in the CBC, particularly in providing aedioal

psyehiatrio coverage for the eaten in the program. The
laboratory director ie responsible for oaintaining the best
standards for laboratory prooeseee. particularly biochemistry
and physiological support services.
and

The ooordinator (a.u. or M.3.w.) is responsible for input
of patient: to the programs, trenefer of patients to other
facilities. and assurance that the prayer permits. laboratory
teats. and rehebilitetivo services are obtained for each patient.
The

bioatatiatioien works with the coordinator

administrative assistant provieee for the collection

tietioal processing

and the
and ate—

of all of the data forms necessary for
the reports requested by the oootrector. He may also assist
the scientists in evaluation of their data.

administrative anaiatent and secretary are seen ea
responsible for the expenditure of funds, payroll, purchase of
supplies. equipment, etc,, as wall as serving the reporting
requirements tor the variant parts of this program.
The

research associate, two researoh assistants, and the
eleetﬁloic technician were included as scientific personnel
to assist the investigators in carrying out some of the atmiieo
The

-1-

�Kieffer,

S. N.

M.D.

listed in the proposal.

~2~

30

Hovenber 1973

recognized that 3+ positions are
merely token personnel, but this was the remainder of the money
left from the figure of $500,000. It represents a research
assistant and electronic technician for the EEG programs; a
research assistant for Dr. Taylor or Dr. Miller; and a research
assistant level to work with Dre. Taylor, Miller. or Der-men.
(We recognise the fact that the funds assigned to Equipment
and not expended in that category can be transferred to Personnel and did so in the plans for the second and third years
of the project.)

gguinuent Requests:

was seen as

we

The equipment

50: the research ward

additional materiel for the 8 beds of the research
office equipment of desks. typewriters, and cel-

unit. The
culators were envisaged as being used by the personnel
word as well as the supporting personnel.

is justified

by the fact that we envisaged par—
senior scientists and that their reports would ordinarily inundete the few secretarial positions
unless we provided the means whereby the reports could easily
be edited. We elected purchase rather than rental, following
the present governmental guidelines that purchase is preferred
where rental costs will exceed purchase for the life of the
project.
The MIIST

ticipation

‘

on the

by 12 or mo;c

Laboratory Equipment consists of two groups of items:
equipment for neurophysiology and peychophysiology. and a
contribution for the genetic studies. In making up this list,
we recognized the fact that Dre. Lodge, Tursky,‘Msrlis. Turner,
and Fink already had equipment to carry out some of their work
and that additional equipment night he provided from the nogotiated requests with New York State for a research center
or other grants to be submitted when the CRC is established.

Alteration and Renovation: After examining the plane
for the research building, we are requesting funds to modify
the facilities for specific research aspects of this proposal,
particularly for psychophysiology, biocthistry, genetics. and
direct patient observation.

It might be helpful to indicate_thet this operationnie
designed to carry out studies in addition to those already
ongoing. The ongoing studies eto:se the V.A. and no funds
are requested for personnel or renovation for the total pro~
gram of evaluation of narcotic antagonists. In the equipmelt
categories, one of the psychophysiology laboratories probably
would he set up at Northport for the narcotic antagonist work;
and the second at the CRC for the many studies of the second
N.B.

section.

HF/cis

�</text>
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                <text>mfp-05-00-027-4-287</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57877">
                <text>1973 </text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57878">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57879">
                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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              <elementText elementTextId="57880">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57881">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="57882">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="57883">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="79990">
                <text>en-US</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="42">
            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="86551">
                <text>application/pdf</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="45">
            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
            <elementTextContainer>
              <elementText elementTextId="93112">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="37">
            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="99673">
                <text/>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
  </item>
</itemContainer>
