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                    <text>May

31.

1971;

Alice A. Leeds, M. D.
Chief, International Rafaranea Center
rbr Information an Psychotropic Drugs
Paychopharmaeology Research Branch

National Inatltuto of Mental Koalth
5600 Fiahara Lana
Rockvilla, Maryland 20852
Dear Alice:

‘
.

When I completed the presentation of ”Etfacta of ACTH
Peptidas on Memory and Brain Function", at the ECDEU Meetings,
the discussion was quite enthuaastic. Thu next day, the presen—
tations on TRY, another polypaptida. were also supported.

Rather than send you an abstract as you requasted tbr
PaychoPharmaeology Bulletin, I am sending tha complete paper.
would be of interest
Should yon.w1ah to publish thin, I believa

the

to the readars. If you feel

it is too

abstract of the length you roquaat.
my

it

long, I will prepare an

beat regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

max
MF:ed

Enclosure

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                    <text>may 31, 197h

Turan

Itil,

M.

38 Godwin Lane

D.

Ladue, Missouri

6312h

Dear Turan:

Enclosed is a coPy of a report which I gave at the
Meeting. as well as the new paper from Lancet which may
interest you.

ECDEU

Should you have another copy of your

appreciate reading

it.

TRH,

I

would

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

Enclosures

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                    <text>.

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York 10021

Deer Nate:

pleased to enclose a copy of the presentation at
I think the effects of the peptides
on brain function is an interesting problem.

the

ECDEU,

I

am

as you requested.

I will be pleased to receive a
available.

handbook should one be
My

copy

of your

little

best regards.
Sincerely yours,

w

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~’--5-rw:~m-w

r,
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was:

any-mummy”

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qmqmvrgwgwwm-

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Fink, M. D.
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MF:ed

Enclosure

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                    <text>May 31 . 197’;

Jovan Simeon, M. D.
Missouri Institute of Psychiatry
shoo Arsenal Street
St. Louis, Missouri 63139
Dear Javan:

I am pleased to enclose a copy of the report on the
peptides which I gave at the EﬂDEU Meeting. Should you be interested in developing such a program, I will do whatever I can

to assist.

my

best regards.
Sincerely yours,
Fink, M. D.,
Professor of Psychiatry

Max

MF:ed

Enclosure

�</text>
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2

January 1974

Bi) Bear Development Company
P. 0. Box 597
Steamboat Springs, Colorado 80477
Gentlemen:

I regret that I cannot attond the Winter Conforenoo on
I wish to cancel the renorvation mod: on

Brain Rosourch.
my

behalf by the Committee.
Thank you

for your cooperation in this matter,
Sinconcly yours.

Fink, M.D.
Profoosor of Psychiatry

Max

Hr/cio

�</text>
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2

John E. Overall, Ph.D.

January 1974

,

Departmont of Neurology and Psychiatry
The University of Texas Mbdical Branch
Galveston, Texas 77550
Door John:

if

Thank you for the reprints. I would be grateful, however,
you chango the address to which you send them to:

Department of Psychiatry
School of Medicine
Health Sciences Canter

State University of
Stony Brook,

New

York
York 11790.
New

at

Stony Brook

Sincerely yours,
Max

Fink, M.D.

Professor of Psychiatry

MF/cis

�</text>
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                    <text>3

Stanley F. Yollos.
m3 Fink.

January 1974

7583-00583

M.D.

MOD 9

Courses. 1973-197h

1.

Bialogicnl Psychiatry-«to lat-2nd year medical studentl.

2.

Brain and Behavior,

3.
4.

Cantar.

2

orcditu.

1

quart-r. Health Sciences

Biological Psychiatry. Residunny Training. Collaborativn

Program.

Bruin tad Bchnvior, lecturo 8.2108, "Balance in naalth

Profasoiono."

Mf/cio

�</text>
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                    <text>3

Jannlry 1974

7483*00783

YILE
Max

Fink, M.D.

Stave Kahn

patterned in a moat satisfactory fashion during
the past 91: months. Ha ha: asaumad additional responsibilitiaa
with the departure of H13. Poiniar.
Mr. Hahn haa

Effactive January 1,

$8500/yaar.

HF/cia

1974,

his atlary

13

incraaacd to

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                    <text>‘MH

1

.w-w—w—‘ur—s—a

m‘wau‘ﬁw’“ "w'mvw

anwrrVMV, Wham-n—Wa-wmnu—‘wqw. c
.

~

n Wm...“ ‘

.

- -7. “men-.mwmnmm m!“"""‘-&gt;)&lt;w"1""'V‘l~f’""-.-‘u

,

rw.-rq-w-m:«,.

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January 5. l97h
,
m,

.r.

M

.

Earl Ubell

WNBC—TV

New

York City

“hwy-y...“

1,...

"my."

”we.

Dear

Earl,

While in the city yesteday, I received a disturbing telephone
from a member of the WNBC news staff, Mr. Gannon (x2373). I wish
to share the contents of the call with you, as be indicated that he
was working on a special program describing the abuses of the private
practice methadone delivery system in the city. He called me because
he had heard that I had objected to Dr. Arthur Zaks going into practice,
and he wanted some information about Dr. Zaks.

call

'—

"

r

The tenor of his questions wasequite hostile; nevertheless,
I indicated that Dr. Zaks was a student of mine; that he had made
significant research contributions in the field of opiate abuse; and

that I had tried to dissuade him from providing methadone delivery,
in part because I believed the community was precipitating this
delivery before it was proven, and in part because I hated to lose
a good

researcher.

tell

Mr. Gannon was most anxious to
me that Dr. Zaks'
that he was reputed to be making a 'fortune';

were run badly;

clinics

that
seen to

ancillary services were not provided; that patients were
leave the offices in Flushing, 'drunk and weaving', etc. These
allegations were based on hearsay and on films taken from across the

street.

I suggested thag some of the problems may be inherent in
methadone, and not in the private practice delivery system. Had
he examined the

enquired of

delivery system.of the public agencies

SAODAP
?

investigations

?

Had he

of the results of their repeated surveys and

What is that ?" responded Mr. Gannon. Since I
could not believe such ignorance cuuld represent a reported in the
field for any length of time, I asked when he had begun this expose,
and he said last year. "Early or late 7" "Since the Burden hearings."
"SAODAP ?

It became clear to me that this young man was approaching
an explosive problem from an inexperienced and probably unprofessional
point of view. I suggested he talk to you, in the recollection that
your Judgement in these matters was most leavened, and in the hope
that if he were indeed an amateur on the trail of a 'story' based
on a politician's desire for instant fame, it would demean WNBC to
be used unwittingly, and would probably harm programs that neither

—.

w.

,.

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you nor

I

awn...“

this time.

;

VWwﬁ“wxn»hv-—-‘

may wish

war. uv-‘Ww-

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to support, but

.

_..

..

..,r.~_

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W_

.

,

,

which have the public support

at

I trust that I am not overstepping the bounds of our
friendship by raising this question with you. As I indicated to
Mr. Gannon, if he has evidence of malfeasance it is his duty to
see that it is tried in the proper fore, the courts, not TV. If
he does not, perhaps he should leaven his attacks by reviews of the
history of the problem and the needs for the present programsTheand
the reasons for private systems, their need, services, etc.
record shows that alternate approaches were suggested but society
did select this approach.
In addition to suggesting he talk to you, I invited Mr.
Gannon to call Dr. Zaks directly. I must also tell you that I
that
called Br. Zaks and suggested that when/if Mr. Gannon calls,
WNBC
the
of
he meet with him only if a senior representative
News staff were present—- someone like yourself or someone sent by

U‘y'v‘rr,~="f'

you.

p"."'v&lt;...~a

TV. I do hope you are enjoying your
much
as you seemed to enjoy reporting the news.
as

I miss your reports on

,

present position

Pw'best wishes for a healthy and a happy l97h.

Sincerely yours,

Fink, M.D.
Professor of Psychiatry
Max

i.
f:

E

,3:

v
van.“

ﬁ”‘.'7ﬁ7ﬁw¢ﬂﬂ‘?‘f'mﬂﬁw'

'::-x

‘Hmmw-W

I’m?"

v

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                  <elementText elementTextId="103864">
                    <text>V‘w‘ v,— s ,

.m

~zr

w

I

.

WWW.__.W—v

7-“...

lmr’v‘mﬁm‘m

k
wr

mm‘rrwwu'

warm-rum"

2-

«NW

m

A

~'

w

wan

Z‘vamm.mmvw

‘42-”,m‘wwv4u‘w'swwA-W

January 6, l9$h
Dr. Moyra Williams
United Cambridge Hospitals
Cambridge, England
Dear Moyra,
7.7

I”

mum-u

w

mam-mnwn

,
-

It

has taken longer than I liked to complete the manuascripts

to have them copied for your use. The ones you requested are
enclosed. The volume is in the hnads of the printer and should be
out in a few months, by April I am told.
and

awr-

r-

‘mpw

arm-cum

hhd hoped to have the summaries printed in the
it seemed too long for them and too much work for one
of us to summarize the discussions in a more concise form. I remember
the meeting fondly and hope that someone will do
again in the next few
We

Archives but

it

years.

Good

luck in the work you are doing.

My

best regards.

Sincerely yours,

Max

Fink,

M.D.

�</text>
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7

Mrs. clan
Grune and
111 Fifth
ﬂaw York,

January

1976

Gould

Scratton

Avcnnc
New York 10003

Dear Mrs. Gould:

I receivad an

attic.

copy of Currant Puzthe correct cover but
contained material from a book on gastroentarology. I roturuad
the volume, as rnquantod.
Bonn time ago

chiatric Thoragz,
I

would

Volumo 13. whiah had

appreciatc a taplnccmnnt offica

copy

for Volun: 13.

Sinatraly yours.
“8‘ Pink, Md)
ProfcI-or at Payehiatry
0

MP/cis

�</text>
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                    <text>7688-01083
7

Scott Briar,

January 1974

Deon

Choirperoon, Search Committoo
Alcoholism and Drug Abnoo Inoriruto

Univoroity of Whohington
School of Sociol work

1.3. 62nd Streot
Scuttle. Hashinston 98105

1&amp;1?

Dear Dean Brior:
Of my atrocious: who have worked in tho field of drug
ebuoo, I con roooumond two who may be qualified for the position of Director of rho Alcoholism end Drug Abuse Institute.

Richard Roonick, M.D.. now director of the drug obuoe research and treatment program of the Deporruooc of Psychiatry.
Now York Modicol College (5 Roe: 102a: Stroot. New York. N.Y.
10029) ooouoed roeponoibility for tho progrou on my loavins
oorly lest year. He ie a tolonted peyohiotrioe with extension
oxporioooe in trearnont of opiate dependonoo. Ho in rolotiveiy
young and adventurous, and may find on invigorion to tho Scorn
of Washington e chollooxe.
Another oedworkor. Arthur Zoke. H»D., established a pri»
vote troetneot program for mochadooo maintenance oorly in 1972.
end it has ovolvod into can of the final: program. in new York
City. He is o talented researcher with a moot pleasing por~
oonolity. He he. arch-wad the university model for thooo pout
tow yours in ordor to aurora a high income. einoo he has very
young ohildron. I do boliove, houover. that he may be interested in on ooadomic poeirion ouch at you have outliood. Bio
hou- oddreoo in as thflowor Drivo, tennfly, new Jorooy 07640.

Sincerely yours,
Max

Fink.

M.D.

Profoooor of Peychiotry

HF/oio

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                    <text>7488-00688

7

January 1974

Alan Ran-0y, M.D.
Madicnl Consultant
Cantor for Studies of

,Narcotic

and Drug Abuse

ﬂntionnl Institutn of Hinttl Hoaleh

5600 Fiuhct's Lane
nockvillc. Haryland

20852

2.:

HSM

52-73-260

Dtlt Alan:
0n Gotcha: 15 w. roquoutod parmiauion to transtar $475.00
from 0.8. Travnl to Foreign T2£VI1 to permit my attendance at
tho HBC~HAS Qualiﬁes. on Problonn of Drug Dapandonca matting.
which 1- beta; hold in Marion City, March 11-14. 1974.

I

would

apprcciatc tho contract apptovsl for thin transfer.
stuccrcly yours,

m
M. Md).
Protcnnor of Psychiatry
Mileis

�</text>
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                    <text>74AP~009AP

7

Junnnry 1974

Gerald L. Klnrnan, M.D.

Suportntandant
Erich Lindtaann anneal ﬁnalth Cancun
Govurnnnnt Cantu:
Sultan. Hasutchusatcn 02114
Dun: Garry:

I hang

gong ovur tho 11st o£“1ndiv1dunln under conﬂidarn-

tian for gloatinn to tho APPA. Thar. arc.unny nuns: about than
I know littlu; for thosa with when I an aeguaintod. I hav: a

The following aro ruceunnndnd for unabordhip:
Cnncro, Gurshon. Inglis, Mbore. Hoshnr, Quintin, Rnsniek,
Rifkin, 3nd Shophard.

fun onunnnto.

I ball-v0 that c. c. Duhlbcrg has 6106.
I an troubled by only an: nan: that I know, that of

A.

Diunacio. While
is a fin: axporinantnliut. my recon: can:nctn with his as a follow aaionciat hnvo bccn unplaanant, and
I vauld ho rcsnrvnd about ro¢ounnndtng him for nunbership in
an crannisation like tbs APPA. My rgstrvations are not very
strong. but his rigidity would anus. I. to try no clue: 0th.:1f thay at. I! Will qualified.
A1

Sincoroly yearn.

m min. 14.1).
HP/cis

�</text>
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                    <text>7488-01283
7

'

Jennery 1974

Alan Henley, M.D.
Mbdicel Consultant
Center for Studies of

Narcotic and Drug Abuse
National Institute of Mental Health
5600

Ftaher'e

Lane

Rockville, Maryland 20852
Re:

HSM

62-73—260

Deer Alan:

During the past two months we have become ewere that a nua~
methadone heve begun to request detoxifinow

her of patients

cation.

u suitable candidates {at neltrexone.

Thane men are

we

have three such candidate. for
I have delayed induction
to cycleeocine~1n the hope that neltrexone would soon he eveileble.

now

date

I

whom

grateful if you eould indicate the approximate
supplies of neltrexone will be eViilehle to this unit.

would be

when

Sincerely yours,
Fink, M.D.
Profeeeor of Psychiatry

Mex

MF/cis

�</text>
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                    <text>7483-01183
7

David

W.

Harris,

January 1974

M.D.

Chief of Staff
Votcrcno Administration
Franklin Dolano Roosevelt Hospital
Mbntroco. How York 10548
Rn:

620/11

Door Dr. Barrio:

Itii.

I

on writing in support of tho apnlicction of Tutnn M.
M.D.. as a resourch psychiatrist at tho V.A. in Mantra-o.

I

havo known Dr.

Itii

ninoo 1958, when our

common

interest

offocto of psychotropic drugs brought no togcthor
incarnationcl
on
coating in Roma. I was instruacntcl in
at
him
Unitcd Statoo in 1963 at his rcccnt posithe
to
bringing
tion at the Minnouri Inititutc of Psychiatry.
in tho

BEG

Be is an outstanding roooarch ocicntint who has workod with
onthuoincn and order in dcvcloping tho whoio fiold of quantita»

tivo ole-trouncophclography and it: applications to clinical psychiotty. In tho many yccrl that on workcd coauthor, I found him
enthusiastic and innovative. no is a dolightfnl person to know
and has

friend. all over the wotlé.

I an pica-0d to :oconnond him no I research psychiatrict
to tho V.A., and I on confidant that his contributions to tho

V.A. progrcao

will be significant.

Sincorcly yours,
Fink, M.D.
Profocoor of Psychiatry

Max

MF/cio

�</text>
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  <item itemId="5907" public="1" featured="0">
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                    <text>7483—01383
7

Health Raeearch Council of
Department of Health

Boon 1020
125 Worth
New

New

January 1974

York

Street

York, New York 10013
Re:

Richard Raenick, M.D.

Gentleman:

I am writing at the requaet of Dr. Richard Reanick in eupof
hie application for a career ecientiet award. I have
port
known Dr. Reenink eince hie reeidency training at Hillside Eoe«
pital in 1959-1961; and aince 1967. an a member of the Divieion
of Biological Paychiatry at the New York Medical College. In
January, 1973. on my recommendation, Dr. Reanick aeenned reeponeibility for the drug abuse reeearch program: as I left for
a new position at the State Univereity of New York at Stony Brook.
Dr. Reeniok has developed into an enthusiastic, imaginative,
investigator. Hie interest nae inetrunental in
maintaining adequate cane loads for our evaluation: of cyolaro~
cine. and in auetainins the etudiea of naltrexone under initially
and reeourcaful

difiicult conditions.

accepted the reaponeibilitiee of lead—
erehip with elacrity and an the demands of the reaearch program
increaeed. gave up hie private practice of clinical paychiatry
to devote full time to these reeeerch efforts.
He

Hie etudy programe in rapid detoxification from methadone
and the clinical pharmacology of cocaine are timely and logical

exteneiona of our present etudiee of opiate ahaee. I
to recommend him for the award he aeeko.

am

pleated

Sincerely youre,
Fink, H.D.
Profeeeor of Psychiatry

Max

MF/cie

�</text>
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                    <text>7483~014SB

10 January 1974

U. S.

Burnau

nap-trunnt of Junkie.

at Narcottan

Bangorous Drug.

and

Wishinstou, D.C. 20507
Gontlonnn:

I

hnvn ruc01v¢d your

with n label angle-ad.

luctnr rusardinz an

A3308

entry

Etfcctiwu Jnnnnry 1. 1973. I discontinund operations
transfurrod eh: rcsponnibiltty {or work
It that location radRichard
Raanick. M.D.. at tho stun rd—
in that program to
argon.

Sincorcly yours,

“.3 Fiﬂk.

Md).

Professor of Puyehintry

MF/cil

Incl.

�</text>
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                    <text>7483-01783

Stanley F. Yollss,
Max

M.D.

Fink. M.D.

Capital Equipnsnt

Tbs docunantation of rsports is an essential product of
tho taaching and rasaarch functions of tho Dapartnant. Such
docunsntation raquirss rspsatsd rsprodnction and an srror-frss
tart, particularly for statistical computational information.
The MT/ST providss tha facility for storags of tsxt, tablas.
and statistical data for rapaatad raptoduction in a variety of
formats. Instruasnts of this kind can, with an adsquats supply
of inaapsnsivs atorass tapas, provids for periodic updating of

dapartnantsl reports. A aingls instrunant can ssrvics from
6 to 15 scisntista (astinats hassd on prior sapsrisncas at two
similar psychiatric facilitiss).

Display Monitor Modal olzwgoktrogia (yard

Copy Unit 5610

Tsktronix)

Bquipnsnt now availabls to tho Dspartnant of_Psychiatry
ptovidss for data procsssinz of usurophysiological analog data
for studiss and trsatnsnt of psychiatric patisnts. Data input
laboratoriss ars sstablishad at sach clinical unit of tha Dopartnant. Tho csntral procassor has only a lino printsr as
a hard~copy output. This doss not psrnit graphic display. although programs are available. Thass two units. Display Monitor
and Hard Copy Unit. ars additions to tho available squipnsnt to
provids graphic summaries of physiological data analytsd by tbs
cantral processor for can at distant installations~~our clinical
cantata. Such units must ha nodifiad for tho central processor.
and rantal is not an scononical courss.
PDP

11-60 Contggllar

ranching functions in nsurophysiological assays in clinical
psychiatry raqnita that studsnts batons acquaintsd with controllsd
*1—

�8. P. YollssI M.D.

~2~

11

anusty

1975

sxpsrinnntation sud controlled data procsssins. Tbs PD? 11-40
allows ths systsnstic prsssntstion of stimuli sad thc rscording
of rssponsss of up to 8 concurtcnt cxpsrissnts. cithsr in patisnts or voluntssrs. This procsssor will be ussd in teaching
nsdicsl candidstss and post-doctoral csadidstcs. Tbs instrussntstion also mskss possibls thc systematic recording of acutephysiological dsta with idsntificstion of stimuli on ths rscordin: tsps, such that ststisticsl processing will be possible.

MF/cis

�</text>
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                    <text>74AP~025AP

18 January 1974

Mr.

J. 8. Jackson

Suite

31

2231 Bancroft Place, N.W.
Washing ton, D. C . 20008
Dear Mr. Jackson:
The next meeting of the Aoericen Psychoosthologicel Asso~

elation will be held to March 7 end 8 at the Sheraton Boston.
Tho subject is the evaluation of psychological therapies.
Guests are welcome

at s nominal registration fee of $5.00.
Sincerely yours.
Max

HF/cis

Fink,

M.D.

�</text>
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18 January 197A

Miss Carol Havana
8AODAP

726 Jackson

Place,

H.W.

Wanhinston, 3.0. 20506
Boar Miss Havana:

lcttnt: from Dal" indicating
on banal! of DA 428 005 (SAODAP
Coop-rativc Gltﬂienl Study of LAAM and Hichndonn~~Axthur 23kg)
at.

Enclaacd

coping of two

that tha assuranna submitted

bu: bnan aecopcud.

I trust that thus. latter. complete

this anpcet of

Dr. Zaka' study.

yob§ £110 rcgnrdina

Sincarcly yours.
HI: Fink. H.D.
MF/cis

m1.
ac:

A.

Zakl,

M.D.

�</text>
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18 January 1974

Shirlia

NINE Rm.

5600

Werner

9-101

Planet's

Lana

Rockvillo, Maryland 20852
Dear Ms. warmer:

I would like to indicate that Mr. Peter Irwin, my laboratory
supervisor. will attend tbs ECDEU mooring 1n Kny Bineaynn in May.
I unuld be grateful if you would 11:: him (at my Untvcrnity ad~
dress) a: a participant, and Iand him the reservation forms.
Thank you.

Sincurely yours,
Pink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>7483-02783
18 January 197&amp;

George 8. O'Brian, H.D., Ph.D.
Associata Director
Scientific Division
Dopartnont of Clinical Raaaatch
Abbott Laboratorioa
16th and Sheridan Road

Rorth Chicago,

Illinois

60066

Dear Goorsc:

I ragrot that further clinical touting of Abbott

boon suspendod. As toquaatad,
naturiala on this compound.

I

on

4017&amp; has
tho
background
returning

Whoa we first began our studies of oannabia in 1968, we
had no idaa that on would find thin study an fascinating as
has Qnrnad out to be. Tho vary low toxicity of tho tattahydro~
oannabinol molecule, combined with
high dasroo of CBS pona~
an idaal nucleus for the dovolopmont of a shorttranoa. make
aoting. high—potency payohoaotivo compound. Our observations that
tolaranco development is vary slow duo of vary low dasrca anhancoa
out approoiation that tho biological activity of compounds with
this nnolaua any ha of antrcna importance in clinical psycho~
pharmacology. I hop: that the ptoxrnma at Abbott will continua,
and I look forward to an opportunity to atudy than. compounds,

it

it

it:

should they bacon: available for Phaaa I
My

testing.

boat parsonal regards,
Sincerely yours,
Pink. M.D.
Professor of Foychiatry

Max

MPIcia

BMl‘o
oc: Dr. A. S. Knlkarni
’

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                    <text>7488*02883

18

F.

January

1974

Gilbort McMahon, E.D.

Professor of Medicine
Tulane Univorsicy School of Medicine
Department of Hodicino
1430

New

Tulsa.

Avenue

Orleans, Louisiana 70112

Door Dz. McMahon:
and

I wish to thank you for your letter of information of January
look forward to seeing the volumes no they are published.
Good

oyupooium.

luck in your efforts and in the dovolopmone of your next
Sinceroly yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/oio

7

�</text>
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                    <text>7483-02933
18 January 1974

Daniel

APA

X. Freedman, M.D., Chairman
Commission on Drug Abuse

University of Chicago
Department of Psychiatry
950 East 59th Street
The

Chicago,

Illinois

60637

Dear Dan:

I have read the report of the

on Drugs, as

written

by Roger.

Ad Hoc

Coordinating Committee

It is

quite clear that there are a limited number of na~
tionslly~known consultants who are called upon to respond to‘
national issues in the form of drug abuse. Because their num~
bars are few, they also are also called upon by various national
organizations. It was my understanding that the AMA Committee
on Drugs had for many years assumed the leadership in the field
but because their membership reflected nominations primarily
from them , that committee did not reflect the opinion of the
younger, progressive members of the other
developed an expertise in this area.

societies who have

proposal by Roger suggests the establishment of an APA
Council on Controlled Substances and Alcohol, with a budget in—
cluding a consultant. I concur with this reconnendetiou but
would suggest one additional step. Perhaps the APA would con.
sider the development of a National Council on Controlled Suh—
stsnces and Alcohol to represent the point of view of the APA,
ACNP, Society of Biological Psychiatry, NRC—HAS Committee, Ameri—
can Psychopathological Association, and such other similar agen~
ties of which you are a leading member. Should many of these
organizations be brought together and should their treasuries be
tapped (expecially the ACE? and APA), then one can envisage sup~
port of an active office in Washington to represent the various
views of these organizations on drug problems.
The

At the least, I am writing to concur with the recommendation
of a council and a consultant for the APA.

Sincerely yours.
Pink, M.D.
Professor of P sy-chiatry

Max

MF/cis

cc: Roger E. Meyer,

M.D.

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                    <text>7483-02683
18 January 1974

Dr. J. Silvio
Clinical Drug Studies Section

National Institute on Drug Abuao
National Institute of Montal Health
5600

Fichct'o

Lana

Rockvillo. Maryland 20852
Door Dr.

no.i

silvio:

HSM

42—73*260

wish to report that during tho quarto: October 1 to
In averaged 19 patients each month to tho
about
drug
trontnant facility at tho Notthport VAR. The majority
adminniono
tho
of
unto multip1o~drug abuoorn, including abuse of
wu

Docombor 31, 1973.

alcohol.

In the third wook of Novunbor. tho fit-t patients word in—
ductod into tho lovomothadylwnnthadonc cooperative study, and
on Dacoubcr 31, nine pationto wort inducted into the study. No
difﬁtlultico or aid. offsets have been oboctvod, and acceptance
of this ttoatnont rcginon has boon good.
During Doccubot on dotoxifiod thtco patients in anticipa~

tion thnt ooltrczono would to availohlc. Supplies not being
availablc, those pationto have boon roinductod into methadone

maintcnnnoo.
two

Staffing tannins unchanged, and on are activoly recruiting
additional counselor: for tho expanding outpaticnt part of

tho program.

Attached

is a table dcactihing the caucus for this quarter.
Sincotcly yours,
Fink, H.D.
Profcuaor of Psychiatry

Max

MF/cis

Att.
cc:

D. R.

Charlton

�</text>
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                    <text>7483-02483
18 January 1976

Frank

M.

Berger,

M.D.

680 Madison Avenue
New York, New York 10021
Dear Frank:

I am pleased to send you a copy of the report on cyclazo~
cine as an antidepreaaaat and a few other reprints related to
the EEG profile mothod--a method which permits us to anticipate
the clinical application of putativo psychoactive drugs.
I understand that you have left the formal, quiet halls of
industry to enter the more bustling fields of consulting.
My

best regards,
Sincerely yours.
Fink, M.D.
Profaeaor of Psychiatry

Max

MF/cia

Encls.

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                    <text>7483-03083

18 January 1974

Beckman—New

Dimensions

2500 Harbor Boulevard

Fullerton, California

92634

Gentlemen:
have received the announcement of the New Dimensions
audio—vioual technical programs. We are interested
of
series
EEG—l,
"Electronics for EEG Technicians."
in
we

appreciate the opportunity to review this series
prior to entering our purchase order. Should it be possible,
please have your representative call me at the University.
we

would

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>7433-03683
21 January 1974

Graduate School Admissions
Box 1504A, Yale Station
New

Haven, Connecticut 06520

Gentlemen:

Re:

Steve Kahn

I am pleased to submit the following information regarding
association with Mr. Steve Kahn, who is applying for adnis—
aion to your graduate school to continue his studies in psychology.
I have known Mr. Kahn for over a year, first in his role as a
volunteer in our study programs and, since July 1, 1973, as a
research assistant. While a student at this university, he volun-

my

teered to participate in neurophysiological and behavioral experi—
in this laboratory. we found him a cooperative, bright, and
reliable participant, and when we sought an additional research
assistant, we accepted his application.

ments

Since July he has learned to record EEG and to obtain behavioral date from our ongoing experiments, in which volunteers
receive psychoactive drugs and are observed for periods up to
four hours following such administration. In addition, he has
operated the IBM 1800 computer system, including the EEG data
reduction and statistical analysis. He has carried out multi~

variate statistics

and

interpreted the results

up to

writing

a completely documented report. At the and of six months of
tutelage, I was pleased to recommend him for a promotion and

raise.

Mr. Kshn

is

an

intelligent, dependable,

and cooperative young

accepts responsibility well. I believe he is qualified
for graduate study in psychology, and he has demonstrated his in~
terast by his work in this laboratory. I recommend him for the
program which he has applied for without reservation.

man who

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>7483—03783
22

January 1974

Joli Yarvura-Tobias
North Nassau Mental Health Cancer
1691 Northern Boulavard
Manhassot, New York 11030
Dr.

Dear Dr. Yarvura~Tobiasz

I would like to propose a symposium at tho forthcoming
World Congress of Biological Psychiatry on the subject of
Quantitativa Elaccroanccphalography
Psychophsrmacology.

I

would proposa to

intita participants

who

and

sra contriﬁuting to

our nndarstanding of the offsets of biological therapies (drugs
and induced convulsions) on brain function in man, using conputar analytic methods for tho naasnrnmant of CNS changes. ﬁnch
progress has been made in tho analysis of testing 836. focusaing
on froquancy and anplituda changas; on potentials avokad by san~

sory stimuli

of

CARP);

and by

anticipatory sat (CHV). Tho number
and I would suggest sons of

potential contributors is largo

the following ha invited:
M.

Saito

Osaka, Japan

J. Roubicak

Basel, Switzerland

D. Rosadini

Genoa,

T. 1:11

Istanbul, Turkey,

H. Mstousck

G8tsbor3, Swsdcn
Darmstadt, Germany

G. Dolca

L. Goldstain
C. Shagasa

J. Volsvka

Italy
and New York City

Jersey
Philadalphia, Pennsylvania
Rutgers,

Raw

-1-

York

Haw

City.

�Dr.

J. iggvurnvrobion

‘

22 January 1974

~2-

symposiua o! throo hours would allow the actcndaon to obtain an overview of tho progress in this field. which has been
grant during tho past few years, particularly in defining drug
A

affaots. nonnatioa bioavailability of psyohoactivc drugs.
defining the lototalixcd affect: of induced convulsions.

and

I trust this symposium could be iniéndad in tho program.
Should it b. tangible. I would proposo to call on Professors

Roubicek and 1:11 to

the ncaaion.

that. tho responsibility for organising
Sincerely yours.
Fink. M.D.
Professor of Ptychiotry

Max

HF/ois

cc: T. 1:11. H.D.

J. Roubiook,

M.D.
C. Shannon, H.D.

�</text>
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                    <text>7433~06083
24

January

1974

Hard Pigmen. Ph.D.
Chairman, Tenure Committee
New York Hedicel College

Graeolsnds Hospital

Valhalla,

New

York 10595

Dear Dr. Pigeon:

I an writing in support of the appointment of Torso

M.D.. es Professor

Medical College.

in the Department of Psychiatry of

M.

New

Itil,

York

I have known Dr. ltil since 1958, when our common interest
in the EEG effects of psychotropic drugs brought us together
at an international meeting in Rome. I wen instrumental in
bringing him to the United States in 1963 at his recent position at the Missouri Institute of Psychiatry.
He is an outstanding research scientist who has worked with
enthusiasm and order in developing the whole field of quantita»
tive electroencephalography and its applications to clinical peychietry. In the many years that we worked together, I found bin
enthusiastic and innovative. He is a delightful person to know
and has friends all over the world.
New

I an pleased to recon-end his appointment as Profeeeor at
I so confident that his contributions

York Medical College, and

to the Department of Psychiatry will be significant.
Sincerely yours.

Pink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>751-0381
24

January 1974

Br. Staphan Saara
Rational Inatitota on Drug Ahuao
Rational Inatituta of Mantal Baalth
5600 Fiahar’a Lana

Rotkvillo,

Maryland 20852

Ra:

Daar Dr. Saara:

33H 42~70-98

I an plaaaad to tranaait tha auunary reports of tho study,
ggrogic gaghiag Uaarg in Greaoa (HEM 42—70-98). Na have aut—
aaritad all tha obaarvatioaa of tha thraa yaara of this affort
and submit thaaa as wall as oopiaa of tho data upon which the
summary is baaad. The 1d volunaa of tha appoadioaa inoluda:

distribution;
(2) control population distribution;
(1) population

(3) summary of acuto aduioiatratiOn Tﬂc,

hashiah, and marijuana

statistical analyaoa.

(6)

Tho auunary and

Haw

York and

trials;

tha data voluaaa rapraaant both work dona in

in Athana.

In tha aunuar of 1973 wa undartook tho withdrawal studios.
Sixtaan aubjacta want through the prooaduraa and tho data are
now in avaluation-tha EEG tapaa are in analyaia in How York,
tho bahavioral and psychological data in Athaaa.
Tha aobuiaaion of thaaa

raporta couplataa the

work under

h2-70~98, aa raqoaatad up to Jana, 1973, arcapting
Contract
tha withdrawal data. It was humanly impoaaibla to complete the
data oollactioa of a withdrawal study, aa wall aa tho analyais
of thin complex aatarial, to aunaariaa tha findinsa as wall as
complatins tho raporta of tho othar parts of tha study program
prior to the propoaad taraination data of Datambar 31, 1973.
In aubmittins the material today, wa boliava ua hava complied
with tho contract to the boat of our afforta.
HEM

Excopt

Copanhagan in
praaantation or publication of tha data

for a nathodological praaantation in

1972. an hava withheld

of thia study.

In diacuaaiona with Professor Stefania in October.
would ba 'taaantad and publiahad

to agraad that three raporta
during 1974:

�Dr. Stephen Sgsrs

~2*

24

January 1974

(l) Psychological Effects of Chronic

Beshish Use-Anoricen Psychiatric

Association,
(2)

Effects of Cannabis
Preparations in Chronic Esshish UsersJournal of the American Medical AssoEEG

and Heart Rots

ciation;

(3)

May, 1974;

EEG
EEG

and

Effects of Chronic Hoshish UsenJournal.

Because the materiel is extensive end findings on clesr,
they warrant extensive explication with supporting evidence.
Professors Stefanie, Freedman, end I hove agreed to formulate
this in e volume which we believe can be prepared by nidosunnor

end published

I had

in

1975.

that either Professor Stefanie or one of his
join us in the analytical phases in December end
Jennery, but this hes been impossible because of their teething

staff

would

hoped

loads. The reports have been completed using mail service.
After the encumbrances of funds ere cleared on Jennery 31,
there will remain an unexpended amount of approximately $4,000.
Professor Freedman, as President of the Amoricsn Psychiatric
Association, was able to arrange for the presentation of the
psychiatric date at that meeting in Hey. We would like to invite Professor Stefanie to do so.

request on extension without additional funding to May 31,
1974. to complete the data analyses of the withdrawal study, to
we

allow Professor Stefania to present some findings at the
and to work with us in the formulation of s volume.

APA.

letter is an offer by the contractor to extend the
contract without additional funds, for these purposes.
This

On

behalf of the International Associstion for Psychiatric

Research, Inc., Professor Freedman and his coworkers at the New
York medical College, and Professor Stefanie and his coworkers
at the University of Athens. I wish to express our gratitude for

�Dr. Staphan

Star;

26

~2~

January 1974

the faith and support which you and your asaociatou have had
its inception in Juno, 1970. The data
of this program have boon moot intctasting and in believo will
make an important contribution to tho complex litaraturo of can~
nabis nan. But abate the facts, no believe w. have demonstrated
that ctoos~cultura1 roaoaroh is foasiblc and doopitc physical
distances, cultural difforancea, and longuago barriors, acionr
tints of good faith can accomplish conplcx missions. Hi trust
that your flith in this program is rewarded by the data horoby

in this ptogram since

831381€9.06 0

Sinceroly yours,
Max

MF/cio

Encl.

Fink,

M.D.

�</text>
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                    <text>761-0391

2‘ January 1974
Coatee Stefanie, M.D.

Protector of Peychiatry

University of Athena School of Hadicine
Eginition Hospital
74,

Vaaoillisaia Sophia

Athena.

Avenue

GREECE

Dear Contae:

I have tried to reach you on a number of occasions and have
failed, eo I on writing to give you a progress report.
The withdrawal data are now in the stepwise linear regression
analysis phaoa. As Aria Linton will tell you, the more relationfind. the more additional analyses
These are progressing, and I ehould be able
of the obaervationo in about two weeks. So
to attract effects that could be related to
ships

we

of haehioh use.
Beoauee

seen to be noceaoery.
to send you a summary
far, on are not able
the discontinuation

I have been required to submit a final report to the

contracting agency by January 31, I have submitted a summary of
the data that we have had on hand up to tho fall of 1973. I am
enclooins a copy of my covering letter and, separately, I have
nailed the summaries that we submitted to fulfill tho contract
requiremente. The aunaariea do not bind you or no in any way
with regard to future amendnont, publication, or presentation.
These reports are not public and are not considered publications.
although the NIDA staff may summarize our findings in their raw
ports to Congroea. When your summaries are completed and integrated with tho findings of the withdrawal atudy, we may submit
an amanded final report to mini. The publication of a volume
describing our oxperioncao would be a more fitting culmination
of those effortl.

I have requested another extonaion in time to provido you
with fuodo to visit the United States. I do not know what action
Dr. Snare may take. but I will write an soon as I know.
Ho

have revised your auggeotiona regarding publication

and presentation of this material. I not with Professor Freedman
and he called the Program Chairman of the American Psychiatric

Association.

A

preocntation, provisionally entitled "Chronic

Haehiah Doe and mental Disorder."
.

-1.

will be

on the program.

�Because an abstract was required immediately, I wrote one. A
copy is enclosed. You will note that the conclusions are vague,
and this will allow you to write what you believe to be true
as the data unfold within the next few weeks. Should you dieagree with the list of authors or the sense of the summary. I
would be grateful if you would amend this immediately and send
back to me by express.

it

we agree with the two other suggestions for presentation
in your letter of January 3. I have asked Drs. Dornbush and
Volavka to summarise the quantitative EEG and heart rate changes
for a report directed to the Journal of the American Mhdical As~
satiation. As soon as this is prepared, I will send it on for
your approval. I assume that the EEG findings will be written
by Tom and that we will have a chance to see a draft. A paper
on tolerance to cannabis should indeed be prepared, but the data
of the withdrawal study is important for this report, and until
these data are digested, this report be delayed. The study of
psychophysiological correlates of cannabis should be written,
probably by Aria Liskos, and we would be pleased to assist in

any way

that

we

can.

To close the books as of January 31, please submit state~
cents for the balance of the funds which have been allocated
for the subcontract. I would hope that you have expanded all
the money by January 31 because we cannot carry this funding
forward. Should NIDA allow an extension in time, we are prepared to support your visit from the remaining funds allocated
to the 8.8. portion of the contract. I do not know how much will
be left, but should there be funds in addition to the amount necessary for your visit, we will nuke these available to you for
continuation of the work to the termination of the contract.

It is

a pleasure to work with you and your associates, and
on the summaries which we have dis-

I look forward to working

cussed.

.

Sincerely yours,

m Fink,
MF/cis

Encls.

MOD.

.

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                    <text>7&amp;88-04283
25 January 1974

Yoshifuni Koehino,

M.D.

3-10-11 Nomechi, Kaneeewe
Iehikewe

JAPAN

Deer Dr. Koahino:

I would be pleased to have you.work with me and constern1ete you on the extensive experience which is reflected in your
professional record and liet of publications.
My laboratory was moved to a new university in January, 1973.
While we have facilities for reeearch fellowe. we lack the financiel moans to support such e fellowship at this time. Should
funds be made available from sources in Japan, which would provide
you with the funds for travel as well as a stipend. we would be
pleased to complete your application. We would require two recommendations from preceptoro known to you; hopefully, one of then
would be from the cheirman of your department. With such lettera
and assurance of support, I will be able to recommend an eppoint~
men: on e research fellow at the Reelth Sciences Center for a

period of

12 months.

Thank you very much for your inquiry,
for the success of your effort.

and

my

best wishes

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cie

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                    <text>r—._——..__er-.

..,__.

i

we.

...__......,l

,

_.__

I.

7......"_......_e,‘w

.

..

.‘ 7....n,..,..._..w ...-

...

w

7.

January 28, 197h

Prof Dr. H. Kﬁnkel
Dr. Giulisno Dolce
CHAN

3000 Hannover-Kleefeld
Germany

Dear Dre. Kﬂnkel and Dolce,

busy at work preparing the document you requested
to tell you
for the forthcoming meeting of the CEAN. I am writing
tables are
the
of
some
and
soon
as
as
text
the
have
completed
that I
I believe
be
sent
to
you.
both
will
and
the text reotyped,
prepared
5.
mid—week
February
next,
by
office
these will leave my

I

am

I trust that this slight delay will not impair the

working of the congress.

I ask that your records be changed so that future
communications be sent to my address at stony Brook, or better
yet, my private box:
May

Mex

The

address at

and messages

my

Fink,

M.D.

P.O. Box 269
Great Neck, New York 11022
U.S.A.
New
York Medical College is
the

there are delayed.

rarely used

by me

best regards.
Sincerely yours,
Fink, M.D .
Professor of Psychiatry

Max

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                    <text>“i, .‘

1.

w.—

“Wu”.-. vs.

\

,v,

un—‘WNHW, "mum-v.17...—

v.“ wavy“

r."-\‘-~»

._....‘--—..—...1w_V»..~im____ivv—w

Charlton
Contracting Officer, NIDA
5600 Fishers Lane
Rockville, Maryland 20872

Mr. D.

Re:

HSM

h2o70—98

Dear Mr. Kharlton,
we have completed the reports and delivered these with
extensive supporting documents to Dr. Steven Szara of NIDA,
completing the project portions of the contract HSM h2-70-98,
Study of Chronic Hashish Users in Greece. I am enclosing a
copy of a detailed letter reporting the status of the project
to Dr. Szara, indicating that we have been unable to complete
the data analyses of the withdrawal phase of the study within
this time limit. we are progressing with these analyses and
shall supplement our public reports with data from these analyses.

It has

been technically unfeasible for Professor Stefanie

staff during the last months of the study to
in New York. We have arranged for a major report on
the results of this study to be presented to the American Psychiatric
Association in May, and we wish Professor Stefania to make this
presentation. As we have indicated, there are allocated funds from
the contract portion of the study that remain unallocated at this
to send

one of his

work with us

time. We have requested Dr. Szara, and now ask your office, to
consider an extension of the time of the contract until May 31,
197h, without additional funds, to allow the presentation-of these
data at the APA, and such additional analyses as may be desirable to

be completed.
‘2'

SKEW'J

we;

January 28, 197h

'2’"

19:99.

,‘.

letter

an

Should

offer

this request be approvable, you
part of the Contractor.

on the

may

consider this

a
N)»

{mans-7.

.
,'

"*1€W_I_IK\€T‘P""'

”um,

may”

I wish to take this opportunity to thank you,

and your

office, and particularly Mr. R. J. Gradwell for their cooperation
in this unusual and interesting study program.
Sincerely yours,
Max

Fink,

M.D.

Executive Director

�</text>
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                    <text>7éSB~OA7SB

30 January 1975

Alan 6110:, M.D.
Scientific Dovclopunnt Group
H.V. Orsunon

0.8

HOLLAND

Dear Alan:

Earlier this auuugr. when w: aura doing our pilot sunning
I rccaived three botclns of tnbloca laballad Bottle

of

GB~9A,

is

658283.

1, Ho. 2, and no. 3. Each conﬁninad 100 tablnts, green,
unleorcd, approximataly 7/32" in diunoter. Th. packing number

Ho.

since

Wu

.

did not an. than; tablet: in our dons-finding studies.
tha design.

we changed

Rather than send than back or destroy than, I would be
you could identify the contents of each Inctla-no
at: than. in out further sending. (Ono should be

grataful if
that u. may
5 mg GB—9h,
Many

one 10 as

anitriptyline,

and on: placebo.)

thanks,
Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Mix

MF/ciu

�</text>
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                    <text>7683—04688
30 January 1974

Mary H. Smith. M.D.

Dcportnont of Psychiatry
Colloso of Modioino
Albert B. Chandlor Hodical Center

Univorlity of Kontucky

chinston,

Kontuoky #0506

Boat nary:
The next ﬂoating of tho-Anorican Psychopathologicol Anoo~
ciation will bu hold March 7 and 8 at tho Benton Sheraton hotel.

topic in on avoluotion of psychological therapies. Tho program format has boon changed to follow tho model so: by the ARRMD,

Tho

tho proaoneationo hoina diocuoood by a ponol
tho two days of tho station.

I look forward to analog

who

will sit through

you thorn.

Sincerely youxa,
Fink, M.D.
Professor of Psychiatry

Max

MP/cia

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                    <text>7488-05453
30

January 1974

Huntington ﬂavor, M.D.
Soorotory
Eaatorn EEG Sociaty
Hanover. Haw Eampohiro 03755
Dear Dt. ﬂavor:

I am writing to raconmand Jon Volavka, M.D., for samba:ahip in tha Eaatarn EEG Sociaty.
I first mat Dr. Volavka in 1968 on the occasion of a visit
to his tonaorch iaboracoriao in Prague. I invited him and the
director of tha laboratory. irofaaaor Roubiook, to visit our
laboratoriaa at tho Now York Madiool Colloza—-an invitation
which :hay both oooaptad following the unwarrantod invaaion
of Cnaohoalovakia by tho Russians. Dr. Voiovka has workod in
tho laboratorioo a: New York Modical College since 1969 and
during thia tin. ha: baon my oaaociaco. I laft tho Collaga in
Soptombor. 1972, and nine. that data ho has acaonad raoponni~
bilicy for ongoing programs in drug dopandonco and alootrophys~
iology.
ﬁn is a wall trained and highly oxparionood invaatisotor
with special talents in aloctrophyaioloay, statistics. oonputor
processing. and the pharmacology of opiatao and cannabis. He
was on important contributor to my studies of ECT and the EEG
attacks of opiates and cannabis.

is a
I: EEG

antatn

pianoura to raeomnand him for aamborahip in the
Society.
Sincoroly youra,
Fink, H.D.
Profouaor of Psychiatry

Max

MP/oio

�</text>
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                    <text>7583.04583
30 January 1975

M. Bursar. M.D., D.Sc.
680 Madison Avonuo
Now York, Now York 10021

Frank

Door Frank:

I am pleased to enclose tho reprint that you roqueotcd.
will be ploasod to know that the use of EEG for idonti~
fication and classification of new psychotropic drugs in being
actively pursued in a number of industrial laboratories in
Europe. including Schoring in Harlin, Sande: in Basel, Organon
in Holland, and a laboratory in Genoa. I would be glad to discuss this work the next time we moat.

You

Best regards,

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

Mﬁloio

Encls.

�</text>
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                    <text>7453*04353
30

Fred Andcrmann, u.n.
Montraal Neurological
3801 Untvcrsity

Mbnttatl, P.Q.

strnet

January

197&amp;

Institute

CANADA

Dear Dr. Andtrnann:

I

pleased to sponsor tha report ”EEG and Behavior Effects
of Naltraxonc in Man.” which in baits submitted for presentation
to the Bastcrn EEG Mbctinx by my £023.: coworkor, Jan Volavkn,
am

Md).

work

‘

I hope that he will have an opportunity to present this
in the next matting.

Sincerely yours,
Fink, M.D.
Profcsnor of Psychiatry

Max

MF/cis

cc: J. Volavka,

M.D.

�</text>
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31 January 1976

Pierce,

Graca

M.D.

Ortho Research Foundation

Raritan,

New

Jersey 08869

Dear Grace:

Encloscd are the curriculum vitae of Dr. Dincman and Dr.
Sungurboy. I would appreciate your adding than. to the IND

amendmsnt
my

for the Itudy of

033—3063

in Iatanbnl.

boat regards,
Sincerely yours,
Max

Fink,

M.D.

Ptofassor of Psychiatry
MF/cis

ﬁnals.

�</text>
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                    <text>January 31, 197‘
Costa. Stafania. M.D.
Univaraity of Athana School of Mbdicina
Athana. Graaca
Boar Coataa,

Enéloaad are topics of the two summaries which wt
submitted to NIDA yaatarday. In addition, VI aunt 16 voluuaa
of tha data output: (the material that
brought last spring and
tho output: of tha work dent by Aria this auanar) as v.11 as
copiaa of the raporta which ﬁt made in 1971 and 1972. I
boliava that the reports warn wall aactptcd. although Rhaa
told ma of many quastiona that wara rained.

it

I have aakad hat to list the quastiona and as soon as
I have then , I will aand than on to you. If tho NIDA
allow: an axtanaion, wt may be abla to Intuit a daftnittva

roport. hopafully written together. which may answer
chair qua-tiona as wall as our own.
Plaaaa «stand

Athana.

my

hast wiahaa to out

many

some

frianda

of

1n

Sincerely yours,

Max

Fink,

M.D.

Protester of Psychiatry

mf/ca

�</text>
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                    <text>7483~05083
1

February 1974

Health Research Council

1020
125 worth Street
New York, New York 10013
Room

Gentlemen:

I on writing on behelf of Dr. Rhee Dornbush. who is applying
for a fellowehip. I have known Dr. Dornbuob since 1967, when
who joined me in our ongoing studies of the effects of seizures
on brein function, memory, and behavior. I have known her on
both supervisor and coworker in our studies of cannabis.
Dr. Dornbush came to no unusually well qualified in studies
of memory function. In our studies of convuleive therapy. she
set up numerous auditory end visual tests, eeeoseed the date,
end provided the enelysee which hire been published.
During our association we beceme interested in the effects
of cannabis on brain function. From 1969 to date, the has been
the principal investigator in the cennebie studies at the New
York hedioel College in which we have eeeeesed the EEG, memory.
end beheviorsl effects of both acute and chronic administration
of cannabis. Because of her expertise, Professor Freedman end I
celled upon her to assist on in the studiee of "Chronic Heehish
Users in Greece"-o contract established in 1970 by NINE. In
this study the was called upon to guide the organization of the
study, relate to the scientists in Athens, provide for the col“
lection of date, enelyre the information. sod prepare the erten~
eive reports. This study program has just been summarized end
submitted to NINE. and in this summary the major effort was hero.
She is s highly intelligent and unusually well qualified
research investigator. She writee well and is well liked by
her coworkers and seeietento. She is able to extract coopera—
tion from the most diffioult of patients and exhibits eque—
nimity and e pleeesnt mood even under the moat execperetins
circumstances. Indeed, her diplomacy bee frequently been put
to use. both by Professor Freedman end myself, when we have
found it necessary to relate to governmental agencies.

-1-

�Health Rgeearch Council
An

~2~

1

Februaty 1974

a coworker, Dr. Dornbush he: made major contributions

to our study programs. As e principal investigator, she has
exhibited the drive, judgment, and enthusiasm necessary to ac~
canplish the mission: which she has eet. She is experienced
not only in experimental peychelogy, research design, and etatietice, but also in the problems of human research.

I have no reservations in recommending her for the fellow*
ship for which she is applying, and I know of no member of my
staff who in better qualified than she.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF/cin

�</text>
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                    <text>7483~05883
1 Fabruary 1974

Paul Kinlholz. M.D.
Profnsoor of Psychiatry
Psychiatrisohc Univornicﬂtoklinik Banal
4056 Basal
Wilholm~xloin-8trnﬁe 27
SWITZERLAKD

Door Poul:

should bu possible for Dr. Gastpnr to work with us this
coming summer. Most of our work in dovotod to the recording
and onnlylis of tho 226. Hi havo no oxpertiso in can or roo~
piration. There are, howovor. soiontioco on this campus who
are wall known (Bernard Inrcky and Milton Lodge). and thoy night
be willing to have Dr. Gaotpar visit. From my oxporionco hora.
I boliavo he might be interested in spending time with Dr. Ax
in Detroit. for he has a fine reputation in poychophyoiology.

It

Should Dr. Gnltpnx be intornstod in working born, I oug~
tell no sonothing about his experience and who:
ho would like to nchiovo in a visit homo. If I can, I will
respond by suggesting tho kind of work that would haip him and

soot that ho

ho

consistent with the
Thank you

work

in the laboratory.

for thinking of us.

My

boot rosardo,

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

H31

MF/cia

�</text>
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1 February 197‘

x. E. Sting. Blanca:
ﬂaw Dinnnoionn

Backnnn Instrununta. Ina.
2500 Harbor Boulcvnrd
tullcrton, California 92634

Dear Mr.

Stine:

I would 11k. to tats advantasc of your 15-day frat trial
offar for BEG~1, "Eleatronicu for EEG Tachnicinnn.“ Hi can
wait for it the 60 days, when you anticipate it will be available.
Thank you.

Sinethly yours.
Fink. M.D.
Professor cf Psychiatry

Max

MI/cis

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1 Fabruary 1974

Gustancr Strvieaa
John Wilny and Sons
1 Wilsy Drtvo
Somerset, Haw Jutlcy 08873
Gcntlcnnn:
Eneloocd plcasc find a copy of John C. Pinhnr'u Encrgz Crisc$2 Pcrugggtivq. as wall as tun invoitun you cant with tho book.
1: not tbs hook I ordarod; in
I an ruturnins the book as
of
otdgrud
Dnccubcr. I
a eepy
gainta Addiction: Origins and
Treatncnt by Scynour Fishar and Alfrud Frcodamn. This '8. a
Halotod Prat: title, and prapayuant of $8.96 (spatial ptiec
to members of thn Amnrieun 601103: at Rouropsychophnrnneolosy)
was aneloaad with my ordar. I an 0:111 waiting to: this book.

it

Your prompt

ciataé.

attuntion in thin nattar will be

most uppr¢*

Sinccroly youru,
Pink, “.0.
Profaanor of Psychiatry

Max

MF/ctl
33:10

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                    <text>7483~057SB

l

Fabruary 1974

.

M

t

.

.

a,“

my.

”Flux"

1::‘--»v-..;v:‘.\pw:nmr.'.-.

r
u

Murray Weinar, M.D.

Vice Pranidnnt-~Rss¢arch
Laboratory Sciences and Clinical Pharmacology

Marrall*National Laboratories

Cincinnati,

Ohio 45215

Dcar Murray:

I will

either you or Peta: Siegler
ara still interested in stadium of antihistamines.
I am not planning to attcnd the NYU alumni wanting on February 23,
as I will be away on a ski trip. I can man: with you the wash
of the 25th. should you b: staying ovcr.

visit am.

my

bu delighted to have

We

best rcgarda.
Sincerely yours,
Pink, M.D.
Profassor of Psychiatry

Max

MF/eis

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                    <text>,.

.1».

—p.my u»-w.&lt;-:yv .-

,

.7

“w- "rm-“WWW”.

u..-—n

_

..

‘

.

.N

--—

,-...._....q..,

‘

.Ym,~~-..m..~.m mum.” ..

74AP-055AP

1 Fahruary 1976

Jocoph Zubin, Ph.D.
722 Has: lésch Street
New York, Haw York 10032
Dear Joa:
and

I

I

havn recatvcd the Naninatins Committee Import from
writing to thank you for your help.

am

Prita.

I undgrstaud from Jon that thd Johns Hopkins Prue. V111
oxhibit thc APPA volumes at tbs Boston anoting. W111 thoy also
exhibit the earlier, Grunt and Strntton isoucaf If not, would
you 11!: to atrnngc that in tons way?
My

bgst regards.
.

Sincerely yours,
Max

ﬁllet.

Fink,

M.D.

�</text>
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                    <text>74AP-056AP
1 Fobruary 1974

Samuel B. Guzé. H.D.

Dapartnant of Psychiatry

Washington University school of Modioino

St. Louis. Missouri 63110

Door Sam:

I

writing to thank you for your holp 1n the Nominating
I have rccatvad a roger: from Frits, and I think
tho suggestions at: orcollcut.
am

Committaa.

“rm-aw»?

,.Vr-""~"v&gt;-‘

.

I kocp heating disturbing hour from 8:. Louis. We wore
visited today by one of tho young fnychiatristo from Malcolm
3110., who tussestod that com: of the cans restriction: on re~
search visited on the HIP at. apparoutly being establishad ac

Bliss. Fran thin distance of 1100 miles, can would wonder if
a concertod effort by IU, M0. and SLU would not be called for,
not only to help HIP ourvivc but to provide a dam for the "knownothing" mantality of middle Hisaouri.
my

thanks for your help,

sincarcly yours.
Max

Fink, M.D.

�</text>
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                    <text>7hAP~05ﬁAP

1 February 1976

Eric: Freyhen,
2015 B

Street.

H.D.

R.W.

washinscon, 0.0. 20009
Deer Erich:

I

for the report of the nominating Cam—
mittee.
feels that he can eccenr
the
aieeion as Secretary for at least one more year.
plieh
went to thank you

I have spoken to Jon and he

I have asked

him to put the Q;

for the next council meeting.

subscription

on the agenda

the Johns Hopkins Pres: will have an exhibit
at the forthcaming meeting. I suggested
the: Jon inquire as to whether it would be possible to put copies
of §g_with a subscription for: either at their exhibit or in one
alongside. Should you think it is a good device. you may wish
to have copies (7 complementary copies) on exhibit at the meeting.

I

of the

am told that
APPA volumes

Again,

my

thenke for the nominating Committee report.

Sincerely ycure.
Mix

Mrlcie

Fink,

M.D.

�</text>
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                    <text>February 6, 1974
Bank ven

Risren.

NJ]. Orgenon
Oss. Bollsnd

lest

M.D.

Bank.

This week-end,

I

was

invited to so eanivsrsery party

and bed the opportunity to have dinner with Dr. Dorothy
Krieger of the Mount Sinai Hospital Medical School. Dr.
Krieser is well known for he: hormone studies and we
chatted about the polypeptide research scene, David deWied,
and eventually OI~63.
She expressed an

interest in using 01'63 in the

treatment of Addison's disease. In the discussion. I
added that I held the IND and she immediately asked if
Not being
she could get some material for human use.
such
for
a
use. I suggested
sure of the proper procedure
wanted to do,
what
she
no
that she write a note telling
how
could
and
I
cooperate.
you for advice.
have
I
would
be
s long
useful,
If you believe this study
would
be
and
husband
not
I
and
her
her
with
acquaintance
advice
studies.Your
her
and
encouraging
her
adverse to visiting

Should she send

My

this on, I will write to

7

best regards.
Sincerely yours,
Pink, M.D.
Professor of PSychietry

Max

�</text>
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                    <text>February 4, 1974
Thoma: A. Hayct, M.D.
Butcnu of Drugs
FDA

Rockvillc, Maryland 20852
Dear Dr. Hayes,

Raf:

IND

8569

had submitted the formulations of the placcbo of
thu ntudy of OI~63 earlier. Evidcntly the docuncntation
hud not rcnchod your office. WI would ho grateful if you
would check the records at the FDA for the oritinal submission,
and trust that the data will be sufficient for the review
We

you envision.

For tbs meanﬁhile, we have indicatad that the placebo
is not to bc used and atudies may continue using a
saline (normal) control.

vnhiclc

Sincerely youra.

Fink. M.D.
Professor of Psychiatry

Mix

miles

�</text>
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              <elementText elementTextId="58712">
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              <elementText elementTextId="58713">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                  <elementText elementTextId="103833">
                    <text>habrnary 5, 1974
Book vac Riezon, M.D.
N.V. Organon

Oas, Holland

Dear Bank,
We

have been notified by the

FDA

that the use of the

placebo formulation in the study of 01-63 and placebo should
be discontinued, until they have had a chance to evaluate the

placebo.

I have called and discussed this modoege with Joyce.
indicates that she has used the material in two instances.
Rather than wait for a decision from the FDA, she indicated
that the study could proceed as wall with normal saline. She
believes that the data will remain valid, that the evaluators
will not be in a position to see either injection, and that
she could procacd with saline.
She

I agreed.
soon

you.

I trust that this judgement meets with your approval.
as I have heard further from the FDA, I will write to
my

best regards.
Sincerely yours,
MAX

Fink,

M.D.

As

�</text>
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            <element elementId="50">
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                <text>1974 </text>
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              <elementText elementTextId="58698">
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            <elementTextContainer>
              <elementText elementTextId="58700">
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              </elementText>
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          </element>
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              <elementText elementTextId="58701">
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          </element>
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            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58702">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          <element elementId="48">
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              <elementText elementTextId="58703">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            </elementTextContainer>
          </element>
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              <elementText elementTextId="86633">
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              <elementText elementTextId="99755">
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  <item itemId="5869" public="1" featured="0">
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                  <elementText elementTextId="103832">
                    <text>7488*05983
6 ¥obruary 1974

Dr. Victor Toichnor
Dopaxtuont of Psychiatry

Hotropoliton Hospital
97th Strooc and 2nd Avonnc
Nov York, Now York 10029

Door Dr. Toiohnar:

I have

known Dr. Alvin Bronson

both acudonto at

How

since 1942,

York Univoroity.

'

whoa no were

During the past two years. he has boon working in the nar~
cocic addiction unit of tho Department of Psychiatry at New York
Modioal 001103.. Dr. Cronaoo in a oophiatioatod and careful
psychiatrist with exocllont training and oat-asivo oxporiooce.
Ho aocopted the challenge of working with narcotic addicts and
hot done a oomnondablo job.

I

would recommond him

plying without rcncrvation.

for tho position for which Is is ap»
Sincoroly yours.
Pink. M.D.
Profeaaor of Poyohiatry

Max

MF/ois

�</text>
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                <text>Correspondence to: Morris, Robert W.</text>
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              <elementText elementTextId="58690">
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J...

4‘

W

7488~06188
6

February 1974

Joyce 6. Small, M.D.

Carter Mbmorlal ﬁoupltal
Street
Indianapolis, Indiana £6207

Laruo D.

1315 was: 10th

but: Joycc:
In checking our records, we can only recoumnnd two report:
which arc relavznt to the problem of maincannnca ECT. Thane are:
Geoghcgan,

J.J.,

alactroahock.

and Stevenson.

Amqgg

6.3. Prophylactic

J. Paychlat..

105:694~é96 (1949);

Karlinar, W., and Whhrheim. 3.x. Maintnnanco con—
vulsive trcatmnnts. Aunt. J. Paychlat., 12121113~
1115 (1965).

Gooshognn and Stevanson 1: the only

satisfactory article.

I

havn discuscad our cxpatlcnce with Dick Abrams, and he
of no EEG studies with maintenance BOT and confirms the
shaman: of adnquata control studina.

knows

my

best ragards.
Sincercly yours,
Pink, M.D.
Profeusor of Psychiatry

Max

MP/eia

�</text>
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                    <text>7483—06288
6

Mr.

Charles Schultz

Burcuu of

narcotics and Dangerous
v.3. Departunn: of Justice
555 West 57th Street

February 1976

Drugs

ﬂaw York. New York 10019

Dear Mr. Schultz:

Enclaacd is a copy of my roapnnno to thc
from the Drug Enforcenant Adainistrntlon.

letter of

Rovenbur 12

In chacktng the paper: available to me frém A3008, I have no
rnacon to changa my opinion submitccd on thnt data.

sinearoly years,
Pink, M.D.
Professor of Psychiatry

Max

MF/eis

Encl.

5‘
-~.

.swn

w,

r‘g-n

”Ir

wm

-,—

�</text>
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                    <text>A.

-

s‘mm'”

7483*07033

11 February 197$

Dr. John 8. Tall

Ptcsidtnt
Stats Univcrnity of
Stony Brook.

Dear Dr.

the

Haw

York
York 11790
New

Toll:

I an planned to neccpt your invitation for

Campus~W1do Counitcae on Raacarch

mambcrship 1n

Involving Hunnn Subjncts
and look forwata to participating in tha work of tha Committee.
Encloncd

raeords.

is a

copy of my curriculum

vitae for your use

Sinatraly yours,

33.5,.

.r.

M

wt,-

“v

,_..

Fink, M.D.
Prof-snot of Puyahiatry

Mn:

«4r

uh.

."..;m"

«

HF/ctn
Encl.

and

�</text>
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                    <text>ML

7683~06983

11 February 1974

Hillar, Ph.D.
Psychiatric Institute

Lyle R.

Eastern Pcnnnylvania

Henry Awanno

Philadelphia, Pennsylvania 19129
Dear Lylo:

Bank shared with an your letter of January 22, and I am
pleased to lend you a copy of tho summary or our axperience:
with high doses of OI~63. a: you requested in your latter.
The only unusual CBS utfacz was the transiant dcvnlopnnnt
of bursts of 3-5 cps, 80—150 uv uqunrins for 5-30 seconds nonn—
uhnro about 50 minutau attnr aha aﬁminisztation. The-a bursts
ﬂute chart and nﬁli—limitod and did not appn&amp;r again for the
raunindcr o! the obsnrvution period. This absurvntion was made
in thrnn subjects-1n on: it was very alas: and in two it was
found only on careful ruvicw of the racords.
my

boat rcgarda.
Sincerely yours.
Fink. K.D.
Professor of Psychiatry

Max
«w

v;
'1
n1.

5
»-

'r-z

:
yﬁmv'w-‘W

war

MF/cia

Eacl.

�</text>
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                    <text>74 AP~071AP
11 Fohruary 1974

Gerald L. Kleruan, K.D.

Professor of Psychiatry
Harvard Radical School
hoasaohuaerrn Gonoral Hospital
Boston, Masaachuactts 02114

Boar Gerry:

I havo received your lcrtar of February 6 rogarding the
relationship barwocn the APPA and Comprahcnsivo Psychiatry.
While this problem has been discursed many tiara, I believe
the response of the publinhnr to Fric: to our recent inquiry
is the first time that tho publisher hot boon willing to
considar a opacial subscription rate for APPA mombers.
Tho question of editorial policy, the appointment of the
Editor, and nominations for the Editorial Board are matters
that were discussed. Fritz was able to satisfy the questions
of the Council at that rims. Suhacqucnc to that mooring, the
officers of that period (1972) were appointed to the Editorial
Board. The appointncnt of rho Editor, howovcr, second out~
aids the purview of tho Association.

I have aokod that rhiu mortar be put
I look forward to the discussion.

on tho agenda, and

Sincorcly yours.
Max

Mﬁleis

cc: Dr. F. Froyhnn

Fink,

M.D.

�</text>
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                    <text>7453-07283
12

rahruary 197k

M E HVO R

A.N

To:

Wilton w.-Shroava, M.D., Ph.D.
Acting Associate Chief of Staff for Raunarah

D U H

VAR-Hoxthpor:

Fink. M;D.
Protaaaor of Psychiatry

From:

Max

subjact: Propoual of Dru.

Sn and Boson, "Molecular Modal

of Morphina Dopandanca"

Ra:

632/151. 2/1/74

is a basic acianaa investigation of hypotheses
of abronic opiate use.
tho
pathophyaiolosy
eonaarning
The study

Dru. Sn and Boson propoaa to no: tho oholinargie aspacta
of the nouronnscular junction of rat diaphragm to stamina the
oignifiaanca of acatylcholinc inoraaaa in dependence and ab~
atinanaa. The study in wall daaignad. tho nathoda are faaaihla,
and tho authors hart axparicnca in using these nathods.

prison: version of the yroyoaal is very much improved,
with an axonllont rationale and a more detailod praaontation
The

of methods.

Tho study does not involve human

subjects.

The authors toquaat tho VA to outablish the laboratory and
request no funds for pataonanl and only limited ouﬁpiina during*
aha firat your. Thu oaoond~yaat augment in modaat, consisting
half in aquipuont and half in taohniaian support and supplies.

Racoamaggation:

If ch.

VA

in ahla to provida basic science

laboratory aquipnant for a nonrpatianc~oara effort through itsand
establiohad grant machaniama, than tho hodgat is appropriate

relevant. avan mode-t.
Approval
MF/cia

is

reconnaodad in the amounts raquaatad.

�</text>
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                    <text>7488-06683
12
Mssami

Saito,

Fsbtusty

1974

M.D., D.Msd.3ci.

Dspsrtocnt of ﬁscropsychistry
Xsnssi Msdicsl Collcgs
Ossks~Horixuchi

Jspsn

Door Dr.

Ssito:

The world Congress of Biological Psychiatry will be hosting
Aircs, Scptsmbsr 26~28, 1974. Following soon discus*
sions with combats of the Program Committsc, I proposed to the
Secretary. Dr. José Ysrvurswlobiss, that wo hold s symposium on

in

Buonos

the suhjsct

Qusntitstivs Electroencephalography and
Psychoshsruacology.

This auagsstion has been sccsptcd. and I am writing to in~
you to psrticipsts in this symposium. us would hops to
focus on both ths methods now in nos for qusntitstivc EEG. as
well as applications in classifying psychoactive drugs and tho
nontally ill.‘ Our aim would be to describe the cathode now in
use and the lstsst data to highlight olectrophysiologicsl methods

vita

as applied to biological psychiatry problems.

as arc not planning to request funds for participation and
on csch participant to providc the means of sttcndsncs.

will count
The

invitees include:

J. Rouhicck

Basal. Switcsrlsnd

D.

Rossdini

Genoa,

T.

Itil

Istanbul, Turksy, sod

14.

Motousck

Gﬂtsborg, Sweden

-1-

Italy
Now

York City

�Mo

831:0,

MOD.‘

nomad. $91.

12 F.bruarl_ 1974

”2"”

G. Dolce

Datustadt,

L. Goldscein

Rutgers,

C. Shagaaa

Philadelphia, Pennlylvania

J. Volavka

New

York

Gnrmnny

New

Jorsey

City.

Should you be planning to attcnd tbs Congress and would like
to participate in this symponiuy, I would b. gratoful for your
raply befora March 31.

Sinccroly yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

�</text>
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                    <text>7483~067SB

13 February 1976

Dr. Jiri Roubicek
Neurophysiology Laboratory
Sundae Pharmaceuticals
Basel, settlerland

Dear

Jiri:

Enclosed is a fotmnl invitation to participete in a symposium
at the forthcoming World Congress of Biological Peychietry 1n
Buenoe Altos. Should you b: planning to attend the Congress, I

would be honored

if

you would share the

izing the session with

me.

responsibility for

organ—

To that and. should you have additional euggootione regarding
the perticipento or the focus of the tee-ion (Which I believe will
be three hours in length), I would be grateful.

the least. t tan and I decided the: we would entertain
the pettioipents in some feetive way. and we would be pleased to
have you join us in nuance-Aires.
At

My

beet regards,
Sincerely yours,
#’

Me: Pink,

“.0.

Profeeeer of Psychiatry

HF/cie

ﬁnal.

�</text>
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                <text>1974 </text>
              </elementText>
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              <elementText elementTextId="58610">
                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
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            <description>An account of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58611">
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            <elementTextContainer>
              <elementText elementTextId="58612">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="58613">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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            </elementTextContainer>
          </element>
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            <name>Language</name>
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            <elementTextContainer>
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            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="93185">
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              <elementText elementTextId="99746">
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  <item itemId="5860" public="1" featured="0">
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                    <text>76$B~07683
13 February 1974

William Guy, Ph.D.

Coordinator for

ECDEU

Data Analyses

Univoraity
Bionotric Laboratory 11501 Huff Court

The Goorge Washington

Konninston, Mhryland 20795
Din! 3111:

I an pleasod that thorn will be a togionol workshop for
battery. I would like to send our data coordinator,
Minn Shorty Thompson. to ottond. Unfortunatoly, I will bo away
from my laboratory during that wank. Miss Thompson boo not had
direct oxporionco with BCDEU forms. for on have sobnittod a pro~
toool to tho VA Roooaroh Connittto and it is boing oonnidorod
now. nor principal oxporionoo is in the evaluations of the VA
tho

ECDEU

Cooperativo LAAMFHotbadono Study.

If it would be appropriate, I would like to have hot ottond
rational workshop to booono familiar with the ECDEU battery.
If this is inappropriate, please advise me. and on will make or"
rangcnonto at a lotor tine.
ails Thompson is ablc to attond on any of tbo date: listed
tho

(Pabruary 26, 27, or 28). I would be grataful
vino bar diraotly. Her nddroau in:

if

you would od~

Word 64A

Hospital
Rorthport, How York 11768

VA

(516) 161-4600 x2517.

Thank you for the invitation, and
from tho experience.

will benefit

I trust that

Miss Thompson

Sincoroly yours,
Fink, H.D.
Profo-sor of Psychiatry

Max

MF/ois

cc: 3.

Thompson

�</text>
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                <text>1974 </text>
              </elementText>
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              <elementText elementTextId="58598">
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            <elementTextContainer>
              <elementText elementTextId="58601">
                <text/>
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            </elementTextContainer>
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            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
            <elementTextContainer>
              <elementText elementTextId="58602">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="58603">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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              </elementText>
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              <elementText elementTextId="93184">
                <text/>
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        <name>Correspondence</name>
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  </item>
  <item itemId="5859" public="1" featured="0">
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                    <text>7583—07383
13 February 1974

n

E M O R A R D U H

To:

Stanley P. Yollco. M.D., for walton W. Shrcava, H.D..
Ph.D., Acting Aaaociata Chief of Staff for Raaoarch,
VAH~Notthpott

From:

Max

Fink. M.D., Profcaaor of Psychiatry

Subject: Proposed Studios of Alcohol Dapondance at VAB-Northport
were urged to develop studies in alcoholism
at VAR—Notthport to oupplomant the ongoing rascarch weafforts 1n
proposad
the treatment of opiate dopendenon. In Soptanbor,
a notion of studies to answer thrno questions:

Last guano:

we

tolerance dovalop to long-acting
bannediasopinoa?
Docs

Boas coloranca to a bonnodinaopino pto~
Vida "blockade" to alcohol (by cross-

tolarance)?

If such blockade occura, can it be put to
clinical use tn tha maintenance of chronic

alcohol~dapandant Iubjocta by high doses of
a lags—acting bonnodiasopine?

In this projact.

wa proposed

to no: a

new

bonzodiachinc,

is particularly promising because wc
hava obaarvou a duration of action that in conoidotably longar
than other known bonaodiaaopinaa, nonaurcd by clinical observa—
I have extions, KEG oxaninntiono, and blood level studies. Unitad
States
tonaiva axpartenca with this compound, both in tho
OR!~8063. This compound

and Turkay, whora

cally acttvc.

I

havo found

it

-1-

to ba Info to use

and

clini-

�YolleslShreeve

13 February 1975

-2~

Since submitting this proposal, on have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of
the experiment. I believe we have answered the design and safety

questions satisfactorily.

In Decenber the Committee requested that we give than an
nunber; 1 indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971. referred to studies than approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
protocols to the FDA for repeated administration of the drug in
can. These studies have not only been undertaken but have been
published, and include two reports submitted to the Committee:
"On

the Anticsxisty Properties

of'a

New

Benso~

gygg;.Thsr..Rss., 15:
288 (19?3). In this study, Sskalis and his
co~workers have given 0R3a8063 for 21 days from

diasepins,

oar—8063."

30~150 as a day.

-

"08F;8083, an Early ﬂuctuation of'a Haw Anti—
anxisty Agent.” Curr. Ther. Rust, 14:664 (1973).
In this study, Gallant and his nodworkers re—

ported the treatment of

8

chronic alcoholic

inpatients for an average of
to 160 as daily.

25 days, from 10 mg

In addition to these two published studies, I have submitted
capies of reports of my own work; and indicated that I an personally aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day. in a study which I am
aonitoriug in Istanbul. I also attended a conference (June,
1973) at which 7 investigators (including Sakalis and Gallant)
presented data on varying dosage schedules in man for extended

periods.

in requiring a letter from the FDA justi~
tying this study. is asking for a procedure which the FDA does
not ordinarily follow. In this request. I believe the Committee
is exceeding its charge. Should the Committee persist in this
denand-that we obtain prior approval for a study from the FDAr—
the centers would abrogata their responsibility to decide whether
a study should or should not be dons at the VAHrHorthport on the
data presented. Continued insistence on IND approval as a pre~
requisite for studies will not facilitate research at VAR-“orthport and will not establish that hospital as a center for human
The Committee.

studies.

�YollcsZShtnnvc

~2~

13 Pabrunty 1975

w-mw

"'Wrwwwr»

I halicvu that the Connittcc salad «ﬁnitely in its original
ruquast for 130 duct; tad that I aattd unwingly 1n attunptins to
lag: thslr dcuand. I hulicvn I! havo submittod sufficient in—
foranttan to warrant the judgnoat that the study should be approvud. ¢nd nah your udv1¢o is to the aux: stop for us.

M3/cil

3-th

�</text>
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                    <text>it,

February
Rdbert Robinson,

M.D.

A. H. Robins Co.
1&amp;0? Cummings Drive

Richmond,

1971;

Virginia

23220

Dear Dr. Robinson,

the initial dose-finding studies
of ARR-2277 and are satisfied that single 10 mg doses are safe and
elicit systematic, dose-related EEG changes.
We

have completed

have also completed the assays of the canparison
substance, haloperidol, and are satisfied that single 6 mg doses
elicit systematic effects. We believe that this dose may be above
threshold, hooever, and we are exploring an additional group of
We

subjects at

It

mg.

enclosing a copy of our work-sheets rOr your
information. I have asked my staff to summarize the data of these
initial studies and a report will be sent to you as soon as it

I

am

is completed.

‘

Should the h mg haloperidol doses be below threshold,
we will undertake the comparison, classification study of placebo,
AER-2277. and haloperidol using 10 mg and 6 mg doses respectively.
that dose will be
It the h mg dose of haloperidol is satbsfactory,
used. In either case, the systematic study will begin before the
end of February, and should be completed in 2 months.
Thank you for your

patience, and

my

best regards.

Sincerely yours,
.v

,A

.uy

WNN'W'IV‘wh-rrw-u

-

Fink,
th
Professor

M.D.

of Psychiatry

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                    <text>7483-07583
14 February 1976

Patricia 3.

Gay. Ph.D.
Committee
Search
Chairman.
Rutgers Univcraity
Collage of Arts and Sciences
Camden, Now

Jersoy 08102

Dear Dr. Guy:
on banal! of Dr. Rhos Dornbush. who is boiug
of tha Dcpsrtnant of Psychology. I have
Chairman
considered as
known Dr. Dornbuah sinus 1967, when she joined no at the Now
York Modical College in our ongoing studios of tho offsets of
saicuras on brain function, canary, and behavior. I have known
bar as both suparvisor and co—workor in our studios of cannabis.

I an‘writing

Dr. Dornbush cans to ca unusually wall qualificd in studies
of nanory function. In our studios of convulsiva therapy, aha
sat up nunnrous auditory and visual taste, asasaaod tho data,
and providad the analyses which have been publishad.

intarastad in tho affects
to data, aha has bean
of cannabis on brain function.
cannabis
studios at the ﬂaw
tho
the principal investigator in
During our association

wu

became

From 1969

York Radical Collaga in which u. have assessed tho EEG, nanory.
and behavioral affects of both acuta and chronic administration
of cannabis. Bananas of bar axpartiss, Profsasor Frasdman and I
called upon bar to assist us in tho studies of "Chronic Hashish
Doors in Grasca"-a contract astablishad in 1970 by NINE. In
this study she was called upon to guide the organisation at tho

Athans, provida for the col~
laction of data, snalyra ths information. and prapars tho extansivs rsports. This study program has just boon summarized and
submittad to KIME; in this summary the major offer: was hora.

study.

ralsta to tho sciantists in

intolligant and unusually well qualified
rcsasrch inwsstisator. She writas wall and is wall likad by
her covworkars and assistants. Sha is abls to axtract nonpara—
She

is

a highly

tion from the

most

difficult of patiants
-1.

sna oxhibits cquaninity

�and a plugnnnt mood uvan undcr tan not: exacpcrating circun~
stances. Indoud. ha: diplomacy has frequnntly been put to use,
both by Profocnor Irocducu and nynalt, uhan V! have found it

uneassary to relatc to savornnnntal antaciaa.
Dr. Dornbunh

is

an uncallnnt tuachnr and contributed hnnvily

ta our taaehins programs in biologieal psychiatry, where she pro~

lantnd the nathodology of relcsrch studies, statistics. and tbs
:01. of brain function in unwary. 8h. was well liked by ab:
stud-nun. most of when war: payehiatric rasidcnts.

a co~workar, Dr. Dornbunh has nude major contributions
:9 our study programs. A: a tenchcr and praject loador, aha hts
ancnptod ranponaibility wall and hat axhibitsd the driva, judgnnnt, and unthuaiaam nuc¢nunry to accomplish the a13sions that
war. act for but. A: a principal invcanisntor. aha designad
studios and carried than out in an axnnplary fashion.
As

,,

&lt;
.

.
u

.,

.
.u

I

havn no

reservations in rcaonnondins hat for a position

of loadurship. for I tuna that aha will examplity high standards
of reacareh and scholsrchip.

A...

Sincerely yours.

.4.

.y

A

V.

A.

r...

V
“

Max

"-7.,—

r

“mm—q.

"'~

.,

#,'V\I’§WI“W1~

,,...—,,V‘.,v-&lt;-—

..
m

Fink, H.D.

Prafcssor of Psychiatry

.,.,

HF/cia

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                    <text>7433-07683
16

rubruary 1976

H E M O R A N D U H

To:

Stanley F. Yollas.

From:

an: Fink.

Subjactz

John Kanlcy. H.D.

M.D.

H.D.

I than of thc work of Dr. Hanlcy. Thu curriculum vita.
ruflacto an catanaivu tachniaal background. with a hnavy ¢n~
phauio an ch: eonputational and dloetronic aspcct- of brain
wave recording and analysis.
'

It would be appropriate to consider him for appointmnnc
in the Departunnt. This 10 particularly truo whoa can look:
at Dr. Hanlcy's rccaut interests. aspacially tho contact that
ha ha: vacantly taught. no act-o to be saving in a direction
at not. general applications of his abilities.
I

would rcconmand that ho
:- soon as you deem

seminar.
Mrleia

visit us,

it

pathnpa presunt a

appropriate.

�</text>
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                    <text>7483-07953

25 February 197a

Prof. Dorothy Krieger

mount Sinai School of Medicine
Fifth Avenue and 100th Street
New York, New York 10029
Dear Dorothy:

I very much enjoyed our talk at Alice and Martin's anni~
versary celebration. Because I was puzzled by your comments
regarding the availability of AETE fragmenta, I wrote to my

coworker at 033, Dr. Honk van Riezen. He explained that.
through a series of oversighta, changes in administration, and
administrative enafuo. they had failed to send you the material
you requested. As the extract from Hank's letter indicates, the
fragments will be sent to you as soon as possible. He also is
interested in the rationale for trials of OI~63 in Addison's

Disease.

I

am

planning to attend the convocation on behalf of Morris

Bender on Friday, March 15.
for me to visit you earlier

to

visit your

fragments?

call

at #:00 p.m. would it be possible
in the afternoony~about 2:30~—first.
and its
perhaps your secretary would

laboratory and, oecond, to discuss

If this is feasible,

my

office at

My

best regards,

(516) 44A~24&amp;7.

ACTH

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cia

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                    <text>7483-07883

25 February 1974

Edwin A. Whinstein. H.D.

Professor of Neurology
Sinai School of Hcdicine

Mbunt

Awenna and 100th Street
York, New York 10029

Fifth
New

Dan: Ed:

I look forward to joining you
tion of Morria' service on Friday,
Thank you

and Mbrria at ch: comaemorn‘
March 15, at Hbunt Sinai.

for your invitation.
Sinceruly yours.
Fink. M.D.
Professor of Psychiatry

Max

MF/cis

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                    <text>751~0831

27

deruary

197a

Mr. Arnold Cantor
Andrdw Stuart Associate:
P. 0. Box 325

Purchase,

Now

York 10577

Dear Arnold:

Solootrlc I typewriter.
Ho. 1078) was stolen from the
black, Serial R0.
17. no have notified the
laboratories on or about February
invostigotions, and I believe
police and carried out our own
this is a single act.
IBM salesman to bid on
In surly Daoomber I toquosted on a newt: model and was
against
an sachaago of this typawritor
$175 as a tradaoin.
was
value
maximum
told that the
for your
I trust that this information is sufficient

that an
I regret to report
#551870 (IAPR

IBM

records.
My

boot regards.
Sinouroly yours,
ﬂax Fink, M.D.

MPloin

�</text>
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                    <text>7483-08183
27 February 1974

Joyce Small, M.D.
Larue D. Carter Memorial Hospital
1315 west 10th Street

Indianapolis, Indiana

46207

Dear Joyce:

In looking through my notes for loxapine, I find that it
by Lederle Laboratories (a division of American
Cyanamid), Pearl River, New York. Unfortunately, I have no
relationship with the research people there.

is manufactured

Enclosed are a few
I checked

meeting.

citations from the recent literature

ItilECDEU

notes and found that
on loxapine and the EEG at the 1973
You may wish to call him for his experience.

on loxepine.
gave a Verbal

report

my ECDEU

I have spoken to Holland. and they will ship additional
01-63. I have not yet heard from the FDA regarding the placebo.
They have received my notification, a copy of which is enclosed
for your files.
go to Europe on April 1 and will be stopping
at all helpful, I could present a progress
and, if there are any problems at that time,
statement to
perhaps we can maﬁa adjustments in the protocol. I will call you

at

I an scheduled to

One.

If

will be
itBank

a few days before
My

my

departure.

best regards,
Sincerely yours,
Hex Fink, M.D.

Professor of Psychiatry

MF/cia

Encls.

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                    <text>7583*08088

27 February 1974

Peter J. Fell,
Head

M.D.

of Modicsl Affairs

Fianna Limited

Bnkowoll Rood, Loughborough

Lsioestsrshirs, LEll

OQY

ENGLAND

.Dsar

Peter:
accommodate Tony Croft in our ls~
during tho second half of Mirth. w: will set up a

would be pleased

We

boratories

program which

to

will ineludo observation of our data collection

and data analysis methods, experience in running oxpsrinonts,
and an opportunity to srtofact rscords. Ho may loatn as much

as he wishes about the data analysis, including the statistics.
be spproprinto. we will also go into dstsil with toShould

it

I left anything out?
to visit other laboratories while he is

sard to the behavioral data analysss.
Do

you wish him

here? If so,
.

till he make

Have

the arrangements or should I?

to accommodations. I boliovo he would enjoy the Three
Village Inn in Stony Brook. Rooms cost 312*15 per day. Other
imitations" and have slightly
‘hostslrios arc all~modnrn "ﬂiltonaccommodations
wish
at the Inn or
Should
you
tariffs.
higher
the othar motsls, please let me know.
As

‘

;
'

N

you give him the sons instructions that
you~~to phonn no at 516~644~2447 in the
(daytime or, svonings, st 516~751~é665 or 516~466—5544. I will
probably suggest that he take s limousins to Stony Brook or
Great Neck, depending on whats I so.

I

would ask

that

I originally left for

cal-

�w.

75:.

wwwv—Ju-ﬂqv

wuv

P.

J.

F011, H.D.

-2~

27 February 1974

In confirming these arrangements, 1: would bu helpful if
you would give mm can: information as to Mr. Croft’s background
and training, as well as spacific additional quaationa which
should bu studied whila he is here.
my

bunt regards.
Sincorcly yours.
Fink, M.D.
Profcsaor of Psychiatry

Max

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                    <text>7hSB~0825B
27 February 1974

Fridolin Sulaor,

M.D.. Chairman
Credentials Committee
Yrofcssor of Pharmacology

AGE?

Vanderbilt University
School of Mhdicinn
Hashvillc, Tcnnnaace 37217

no:

Dear Dr. Sulsor:
AER?

Albert Hbissman, Ph.D.

pleascd to spanner the electicn to membership in tho
of Dr. Albert Wainsmnn.

I

am

I havc known him and his work for at lean: seven years, in
his role as pharmacologist at Pfizer Inc. When I studied tbs
naurophysiological affects of doxcpin. thiothixsnc, and CP~1£,368,
during
I found his avaluntions moat hclpful. At various times
ACE?
aha
equally
found
his discussion: at
thesa many years I have
of
nathodology
the
pre*
useful, particularly an to inderstanding
EEG
and
clinical «valuations and their relationship to clinical
asausamancs.

publications attest to his cxpcricncc. and I believe
that as a Fellow he will centributc even morn than as an annual
His

guest.

Thank you

for your consideration.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

MF/cis

Encls.

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.
,-,

_

_,,_w&lt;,,_,,,.c..,..,,

.
_
A

I

February 27. 197“
Coataa Stefania, M.D.
Eginition Hospital
Thens, Greece
Dear Costco,

before the

APA,

Enclosed is the

official

acceptance of the report

to be presented in Detroit

I

invited to

on May 9.

first
of April, and should be free on April 11 to come to Athens
for as
many day; as it may be useful. I should have the results of the
ongoing analyses with no at that time. If that period is convonlcnt
fOr you, I would like to moot with you and to work to the extent or
the time available to us, anticipating completing the discussions
in ﬂew York than you cone some weeks later.
have been

Europe

for the

ten

Is that tins convonicnt {Or you ? (If not,
defer our meeting: mtil you cone to the United States.)
no. In

If it is, I would like to bring
that agreeable to you 7
my

we

can

Dr. Dornbuah with

boat regards.
Sincerely yours,
Max

days

Pink,

14.1).

�</text>
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Valve-my

,

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February 27 , 197h
Robert Robinson, Md).
Robins Co.
1&amp;0? timings Drive

A. H.
«wry-Ir:-

Richmond, Virginia 23220

rm.

Dear Dr . Robinson,

I wrote av note of February

for a week's holidwe,

rev—reading.

and

Just as I was leaving
I understand the lack of clarity on
115

are eatiafied with the single 10 mg dose of
safe and as having central effects. We are unsatisﬁed
with our evaluation of haloperidol. Most of the studies were done
in a short (2 hour) session, and we have since extended the session
to five hours.
We

AER-2277 as

In these extended sessions, the 6 m3 and the h mg
haloperidol were both, sufﬁciently unpleasant ,that we have gone back
to the 2 mg dose, and these assessments have been in progress this

week.

I regret my optimism. We are still exploring the
lower dose: of haloperidol. As soon as we are satisfied, I will call
you and aek that you assist us in setting up the deﬁnitive atuchr.
If we find the data clear by the end of the coming week, we ahould
have a report by the week after (March 15). But we will hit proceed

without further consultation.

W best regards .
.u—w

Sincerely yours ,

‘11

m

W"

Fink, 24.1).
Professor of Psychiatry
Max

,—

_,.,_

,v-u

‘

I;

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                    <text>-,

mane,

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February 27 .
E. N.

Terry,

Dear

Skitch,

1971*

M.D.

Phsrme-Resesrch Canada
Points Claire 730, P.Q.

I am embarrassed that we have completed the data.
analyses, but hove not set dam to write the updated report. The
new analyses confirmed the relationship between FRY—3641. and
amphetamine, and after the consultants were happy with the results,
we were so pleased that we immediately med the data analysis model
for two other studies-—- the withdrawal of hssnish in chronic
smokers, and the relationship of EEG and blood level date. in
volunteers receiving diesepsm or bromssepsm. These analyses have
been completed and again we are delighted with the results, suggesting
that the use or the stepwise linear regression model may indeed

be

helpful.

I

have asked

my

staff to

update the report on PRF~36-CL

within the next two weeks. Should this be time enough for your FDA
submission, I would ask you to wait. If not, you may wish to add these
data as a supplement.

I am most grateful for your support and confidence
in these exercises. I believe we have learned a greet deal, not only
about PRF~36—CL, but about the methodology as well.
My

best regards,

and

my

thanks

50:-

your patience.

Sincerely yours ,
Mex

Fink,

14.1).

�</text>
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27 February 1974

IBM

Office Products Division
366 North Broadway

Jericho,

New

York 11753

Att:

Gontlemcn:
Ono

of the

IBM

Mr. Jay do Lauren

Soloctric typewriters under maintenance con*
from our laboratory. A description follows:

tract has been stolen
IBM

Soloctric 1, carbon ribbon

Color:

Machine
IAPR

Ho

Black

Sorial

4551870
1078.

Number:

Decal Number:

woulo appreciate your listing this machine as stolen
it from our maintcnance contract, offoctivo this

deleting
date.
and

Thank you

for your cooperation in this mottor.
Sincoroly yours,

.v,-.

x
‘

:._

Max

4;.

17er

shown

«pa-or

Fink,

M.D.

Executive Director

.cwx-w-

MF/cio

�</text>
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                    <text>7&amp;33-07333
28 February 1974
M

E

M

0

R A N D U H

Shreevc. M.D., Ph.D., Acting Associate Chief

To:

Walton

From:

Me: Fink. M.D.. Professor of Psychiatry

Subject:

Proposed Studies of Alcbhol Dependence

at

W.

of Staff for Research, VAH~Northport

Last

summer we were urged

st

VAH~Northport

to develop studies in alcoholism

VAR-Northport to supplement the ongoing research

the treetnent of opiate dependence. In September,
a series of studies to answer three questions:

efforts in

we

proposed

Does tolerance develop to long-acting

bencodiesepinee?

Does tolerance to e benzodiseepine pro»
vide "blockade" to alcohol (by cross-

tolerance)?

such blockade occurs, can it be put to
clinical use in the maintenance of chronic
alcohol~dependent subjects by high doses of
e longvacting bencodiecepine?

lf

we proposed to use a new benzodiszepine,
This compound is particularly promising because we
have observed a duration of action that is considerably longer
than other known beceodiezepinee. measured by clinical obeerva~
tions. EEG examinations, and blood level studies. I have ex~
teneive experience with this compound, both in the United States
and Turkey, where I have found it to be safe to use and clini-

In this project,

ORE—8063.

cally active.

-1.

�w. W.

~2-

Shreeve,ph.D.,,Ph.D.

28 February 1976

Since submitting this proposal, we have been asked many
questions by the Research Committee. Most questions are focussed
on the legality of our use of ORF~8063, and only occasionally
have questions been asked regarding the design or safety of the
experiment. I believe we heve answered the design and safety
questions satisfactorily.

In December the Committee requested that we give them an
number; I indicated that this would be a study under the IND
of the Ortho Research Foundation. When they insisted on written
evidence, I requested a copy of the IND letter, and the monitor
sent us a letter they had on file. The letter, dated April 8,
1971, referred to studies then approved and indicated single
doses were then under study.
IND

Since that time, the Ortho Research Foundation has submitted
FDA for repeated administration of the drug in
men. These studies have not only been undertaken but have been

protocols to the

published, and include
"On

two

reports submitted to the

the Antionrioty Properties of‘a

diasspine,

268 (1973).

ORE—8083. ”

Committee:

ﬂaw Benso~

Curr. Ther. Res“

15.-

In this study, Sakslis end his

co~workers have given ORE-8063 for 21 deys from
30~l§0 mg n day.

"ass-8063, an Early Evaluation of’a New Anti—
ansisty Agent." Curr. Ther. Rsa., 1§:664 (1972).
In this study, Gallant end his co~workers re~
ported the treatment of 8 chronic alcoholic
inpatients for an average of 25 days, from 10 mg
to 160 mg daily.
In addition to these two published studies, I have submitted
copies of reports of my own work; and indicated that I am per~
sonslly aware of 20 additional neurotic patients treated for
6 weeks in doses up to 90 mg per day, in a study which I on
monitoring in Istanbul. I also attended s conference (June,
1973) st which 7 investigators (including Sskslis end Gallant)
presented date on varying dosage schedules in men for extended
periods.

I believe that the evidence already submitted is sufficient

for the Committee to determine that ORF~8063 may be given in
multiple doses-ssfely-to men. I am enclosing a copy of en
IND

submission dated

Msy

30, 1973, received by the Bureau of

�w. W.

Shrcsvo, H.D., Ph.D.

~3—

28 February 1214

Jun. 1, 1973, roflecting on a protocol which requires
the multiple—dose administration of this compound to psychiatric
patients for periods up to six wneks.

Drugs on

Committee acted unwisely in its original
data and that I acted unwisely in attempting to

I believe that the

request for

IND

demand. I further believe there is sufficient informa~
Committee for
to judge whether such a study
could be undertaken at tho VAH-Horthport.

meet

their

tion before tho

MF/cis
Encl.

it

�</text>
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                    <text>7453-08683
28 February 1974

Dr. John S. Toll

President

S.U.H.Y. at Stony Brook
Stony Brook, New York 11790

Dear Dr. T011:
would be pleased to servo on tho Unlvorsity~w1do committee
concerned with controlled substances on the campus.
1

You may recall that Dr. Pollogriuo asked no on May 20, 1973,
to assist investigators in complying with the appropriate rogu~
lotions for the use of controlled substnnces, and I have had some
communication in this regard.

Thank you

for the invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/cis
cc: Dr. Oaks

�</text>
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1 October 1973

Turan m. 1:11, M.D.

?rofesaor

and Associate Chairman
of Clinical Neurophysiology
5action
Chiaf,
and Psychopharmncology

Séhoel of Hbdtcina
University of Missour1-Columb1a
5400 Arsenal straet
St. Louis, Missouri 63139
Baa: Turan:
The pragxam

to participating.
my

for the

ACMP

Is ancellent

and

I lack forward

best regards,
Sincerely,
Fink. M.D.
Profasaor of Psychiatry
Max

HF/cis

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                    <text>73AP-73kAP

1

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1-!

—

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a“...

1)!

or. sound 17. Klein
Hillnida ﬁospital

Glen Odks.

'1
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How

October 1973

‘

York 11304

’

Boar Deni

"'rr

‘Wyl’I-G'ﬂo‘zb‘v‘ﬂg

”‘1!“"510"

(”WM

Wm

I an pleasod to confirm my participation at tho APPA meeting
bath on a disco-aunt of tho Friday panol and no a nonber of the
3:33:11 panal team.
I want once again to congratulate

program.
my

you on formulating a

best regards,

‘

~

Sinoarely yours,
Ha: Fink. K.D.
Professor of Psychiatry
‘Mrlcis

fine

�</text>
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                    <text>Catcher 2nd, 1972
F. J. Kuhn. Finns,
Departannt at Ph¢rnteology,
6507
Oil
Whit Gar—any.
7,

in Rhoin.
'

nut: rrnna.
for your letter or Boptanbar 7th

Thank you vary much

-and ﬁha

intcrntﬁion an

HI»1256~MB. I hiv. takcn the liberty
compound amons.those under study for n

of including this
rdport thnt I hnv. swat rininhnd. I an enclosing
for you.
'

,

-

3 copy

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I minted the rcpcrt by Dr. stockhan; in
but in rngdin; t3. reprint I agree that this
interesting antagoniut proportign.
__A'aun.

m.

Ann Arbor.
campound has

than;
‘linccrcly yours."

mt Pink. 3.0.
NF/td

�</text>
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your liberatariqc as an addcndun to an: ruport.

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                    <text>7

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15 Octobar 1973

M E K

0

R A

H D U H

To:

Stanley

Prom

Max

I.

Fink.

Yollca,
11.».-

M.D.

w

Subjact: Tanhiatoacopa, Cit. and lvant Ctntrol Syatan

.

The

taahiatoacope and CF! arc davicas that proaant visual stimuli undar
rigorous control of input variablaa. This paruita tho capatinantat to
naaaura accurataly the Itata of vigilanca of a auhjact and tha lavcl of
brain function parfomca. Chang» in than manna at. diract indicaof organic noutal states and tho affacta‘of drug: and paychiatrit traatmanta. Thay are alao being appliad as a nan-are of the ahanxaa producad
by tha aehiapphtanic ptocaaa. For exparinaatal atudiaa by uadieal ata—
danta and follows. than: davicaa ara invaluabla both as roaaarch and an
taaching toola.
(a.

The Evan:

Control System permit: ch. roaaatchar to present stimuli

through the tachiatoacopa or CF?) with tigeroua central of dura~
tion ..and aaquanca factota. thus permitting careful aaaaaanant of changes
in vigilance, brain function. and tha long~tarn cifacta of paychoain.
This ayatam is also applicabla to tha projaetad studios of conditioning
in our capandad narcotic addiction resaarch program.
HF/cia

�</text>
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                  <elementText elementTextId="103825">
                    <text>«can. -...— wu-r.

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11' I'th-c—d

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an

73SB—739A

October 15, 1973

Alan Ramsay,

3.9.

medical Conuultant
Cantu: for Studias of

Narcotic and Drug Abuse
Rational Institute of Hantal ﬁnalth
5660 Fisher Lana

Roam 11¢, Wayland
Ra:

HEM

20852

h2—73*269,

Dear Alan:

arc writing to rcqucst yarmiasion (a transfer the sum of $k75.00
v.5. travel to tareign trnvel to permit representation at the EEC-HA3
Connittaa on Problems of Drug Dtpendante meeting to be held in Matteo
City, Hatch llwlé. 3975.
from

we

Nb

believe that participation in that aceting would cantribute to

out otudy of thc narcotic antagotitto. As ycu know, these matting:
rcpruscnt tho tingle principal coavocatian of internatianal scientists
with intotctt 1n narcotics. and utttndanca at prior meeting. has been
most

useful.

Sincerely yours?
Max

Fink. H.D.

Praia-sot of Paychiatry

HF/cin

n.»—

n

.u c—‘~-W‘m"—t--’-—

�</text>
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October 15, 1973

Laonnrd 8. Brahon. Ph.D.. H.D.
Dir-ate: of Radical Ina-arch and léucntion
County of Nassau
Dcpaxtnnnt of Drug &amp; Alenhol Addiction
214 Glen Cave Rand
Carla Elude, Haw York 11514

Dist Lani

I rcsret thlt I will b. unable to attend the conference on
naltrexan. on.Ictober 25. As I inéicntad to your ca~workar. I am
leaving for Europe on October 22 and shall be away for thrae weeks.
I

hope ch.

slasion is fruitful.
Sincerely years.

an: Fink, 14.15.
trotcauor of Paychiacry
Kilcil

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Octohcr 15, 1973

17}?

«V

lwzam'H-"a-W.

«r
Wt"

"m1“

W

"W'RP‘W

&lt;x&lt;wﬁwn~

Knrv¢y Blucntonn. M.D.

Bayartnnnt of Psychiatry
‘Ironx—chanon Hospital
1285

Fulton Avon“.

aroma.

New

York lOéSG

Dear Egrvey:

I-raarn: that I was unnuccoolful with A. B. Robina.
I have not heard from Dr. Clark. and in checking with his
aosociates I was told that the firm has no program for
the support of local noctingn.

L

EU

best rczardl,
Sincaraly yours.
ﬂax Fink, M.D.

Profalnar o! Payebiatxy

�</text>
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                    <text>7383~74253

16 Oetoﬁur 1973

J. l
104

A. Churchill
Glouccutcr Place

London

In:

m “E
Our

2.0. 036a2. August

A, 1973

mum:
Plnaso apprtaa In of tha status of tho abovu 0:40: for thrao

(I) copiu a!

man:

ville-Groom.

Wm“

11:

6111113;

vacuum by x.

Gran-

nopctully, Eh. order Ihauld ha on it. any to Eh. Bipartncuc
of Paynhutry. I! not. plan media in; 1:5 :3de for in»

amazon“. purge-u this

smart.

Thank you.

Simauly,

rm.
Profuse:
tux

I#1.

14.0.

of Psychiatry

�</text>
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                    <text>w‘W‘I—vw-v-x

w v~--

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rwgm.u—w~—.-rwm

‘....~.‘.

n-y.....w.mv~m~~r~r»mw.-—«um-=.m "1......” q-rrw.“

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m.-." ...

WW..."

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October 20, 1973
-..mq-.

..A

John R. Hughes, M.D.

The Medical School
Northwestern University
Chicago, Illinois 60611

Dear John,

it has taken to review this volume.
I
to assess the meaning of the
began
until
It
two sections that interested me. I found myself reading and re»
reading the sections, and then it was a difficult decision, whether
I regret the time

seemed so easy,

to

be general or

specific.

I believe the review is too limited-— in part because
I am not well equipped to assess the other sections. For the
opportunity to review the Elul and John sections, however, I

thank you.

~

n.-)'.,r~

«ma»:-

Many

thanks for the invitation and the challenge.

1.7.:

«771'—

Sincerely yours,

“away-WM

W,

W

In:

awn-112M

Sw'W‘r'Wo

.nxrz'

_

WNW""I‘

Max

Fink,

M.D.

v

.

V

m

.

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.,..,‘..

�</text>
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                    <text>7383*74483

17 October 1973

Mr. Konnoth B. Stohl
Box 1522. Station #2

Amherst, Massachusetts 01002
Dear Hr.

stahl:

Thonk you

artiolo to

and

I

for your latter of October 9. Since writing the

which you rotor. I how: loft How York Radical College
am nov at S.U.H.Y. at Stony Brook. Ho do how. o prosron of

research in the narcotic antagonists.

it is not oloar what aspect of the report
principal programs of this Division are in
tho study of the effects of drugs on tho human EEG as well no
spootfic ntudloo of opiates and choir antagonists.
From your

inccroats you.

lettor,
The

Ehould you with to come and visit, I suggest you call my of~
{ice and ottongo to v1.1: thia univoroity. I shall be away until

Hovonber 10, so should you wish

date.

to viait

it

should bu

aftor that

Sinooroly yours.
”ink,
an
Profoooor
HP/cis

HID.

of Psychiatry

�</text>
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                    <text>7353974583
17 Octdbar 1973

Hilton Groanblatt. H.D.
Chicf. rsyahintry Servten

Tutorann Aalinicttatian 89:71:31
Sapulvuda. Californtt 91343
‘35:

665/116, 10/3/73

9.:r Milt:
I am writing in rusponsc to your rogugat concerning
ance with Arthnx'Choxkin, Ph.D.

my

acquaint-

I became interested in some of his studies of unwary changan
1n the*chick when I was reviewing aha literature on 302. I first
Ist=h1m a: thu'wintor Brain Ensearch Conference in 1971. Suba¢*
qunnuly'uhnn I ers‘nixad tha Coufcranea an the Psychabialoay of
Conrainivu Therapy in Puaxto 1:06 in April. 1972. Art Chartin.v&amp;s
can of the inviﬁad participants. He presented his data well and
eontribuecd farcafully to thn discussion. Since then. I have
had a nunbar of cannuniantioas regarding aha reparts submitted
to thn walnut and havo diocuaucd with him a yoaaxblc program of
rascnteh in 308 which may be raluvunt to tha EC? procasa.

all then. alienationn. I have found Art Cherkiu to be knov1~
:dshlbln at tho literaturo. cupcrtcnccd in rusaarch, and critical in
hi: Judsnnnt at rituarch problnnl. My only cxparience regarding
his fanatics II a "team unattr“ wan at th&amp; Contarenac. where ha
partieigacsd nativuly and contributed niznifienutly.
In

unu:

I would have no huaitatton for ricolnnadina his for an appointat this Univoruity and eta anaerua hi: rcconnondacion to: UCLA

with ease and pleasure.

stnehrely youru.
Fink, M.D.
Protasnor of Psychiatry

HA!

'HF/eit

'

�</text>
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                    <text>7383—7663!

17 Octobar 1973

Dr. G. Dole.

c/o Laoaida Goldstcin, 3¢.D.
nutsuru undieal Sahaol
University Haishts
Piacntnuay, ﬂaw Jursay 08855
baa: Dr. Dulce:

I II dalishtaﬂ that you will b: in tha States during tho month
of Novanbat. I will b. :way until Rovaabnr 10. but I will be glad
to have you visit any day thereafter. P1513: call no at (516)-64b2447 after Huvunber 10 and v: can Irrtage a suitable tins.
my
v

best regarda.
Sincurcly yours.

'
"

:H

W

w"

Fiﬁ. HID.
m
Professor of Psychiutry

”my—w

wWWWNWI'I-p‘h

ﬁllet!

�</text>
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i

7385*74383

17 Octobcr 1973

Br. Halter Rosana
Dopartnnnt of Paycholozy

Gallant
Flushing, now York 11351
Qunena

Dan: Walt:

Encloscd

of the can:

:- : ouunary which
Gordon'n valuno

to:

was publishnd

in

1969 and a copy

ray¢hophnrnnaolqg;¢al Aggnts, Vol. 3.

Attar you havo had a chunca to road
sonshla solution so tho dilunnn, pious:

that:

@111

and

an.

if that: 1-

Sincurnly yours.

fink, 8.3.
Protease: of rnychiatry

Max

Mrlcis
ﬁnals.

a ran«

�</text>
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12 Bovcnbcr 1973

3313.11 Gordon. Ph.D.

3:13:01 Liberatoricn

P. 0. no: 657

Syracuse.

Butt

Haw

York 13201

Max:

Your progress with Voluno 3 is enunnnddblo. I htvn abackcd
the tgxt of my aontrtbution sud find that I huvh not taprodueod
nay mutatinl which has bean pnblichaé ptuviously in an idonttn
tiabln fashion; n» toqunst to publiahcra for petuinnian to re~
pradnnn Eh. nicotial is nacanacry.

in

I an tnprculad with ch. alcuably of fin: pharmacologiues
which you hﬂﬂl placad no. and I wish to thank you.

But mums,
sineotnly youru,
Max

rink,

M.D.

Profaaaor of Plychiatry

�</text>
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                    <text>November 13, 1973

Carl Salaman, M.D.
Massachusetts Mbntal Health Center
7h Fenwood Road

Boston, Massachusetts

02115

Dear Carl,

I have read the draft of the clinical report on
elctroconvulsive therapy and have made a few marginal notes. The
principal omission may be in the use and application of flurothyl -or, is that subject included in another chapter 7 For a practical

manual, such an inclusion
The

may

be helpful.

location of elctrodes is difficult to define

from the text. Perhaps you‘would care to include a figure, similar
to one used by.Abrams in a manual he and I produced some years ago.

only hesitation in reading the article came from
your hote suggesting philosophic differences. Except for the
editorializing on page 1—2, there is no disagreement as to content,
application, etc. Perhaps an examination of the usual ambivalence
towards ECT which the introduction reflects could be undertaken by
Dick Shader and yourself, and I am confident that you will arrive at
a more tutorial, professorial, attitude, suggesting perhaps that
in the absence of a more elegant method of symptom relief for severe
My

depressions, the success rate and the cost/benefit ratio of
clearly suggest its continued use.
Good

ECT

luck in your volume. I trust I will see you in

California next month.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>-hTr—ww

m'v‘wﬂv-

,

7383-75583

13 Havaubar 1973

Kr. Jﬂy

Hug
Expericncial Ybyniology Deparlnant
Vazcrann Adminiutration nanpietl
Ho

Sgpulvada. California 913é3
Dear Mr. King:

I r0320: the delay in analyzing ch: tape which you acne
to un. as 1: ttrivud whilu I was in Europa. We chuckgd 1t
ycntsrdqy and Sind Ehlt n. have no difficulty in replayins aha
tint-nave an «eh chm}...

m volugen wen aatufactary.

In ordnr to find tha record. um had to tawind tha tape
real. Apparuntly. sits: the signal: warn put an
the tape. the tag. van novud'by (an: fotward to the taka~up
real. and tho taka-um reel was can: to an. To ondblc us to
follow your sequana. of racorétng, u. ask that ch: tap. be
rcwauad and can: to u: from tbs left, or master. ruol.
unto another

Thank you.

sinautely yours,
ﬂax Pink,

8.9.

Profoaaar of Psychiatry

HF/cis

�</text>
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                    <text>731*7581

13 Novambor 1973

HE. Rs Jo “YWCJ-l

Contracting Officer
Contrscts Kansgsnent Branch
Rational Institute of thtal Koslth
5600

Fisher‘s

Lane

Rockvills. Maryland 20352
Ra:

BSM42~7D~98

Dsir Ht. Gradwell:
Encloscd in s oopy of s latter I have none to Dr. Stephen
scorn. reporting progrsss in the study "Chronic Hashish Users
in Graces" (35H 42—70u98). Progress on this study has bean
ontstsndinaly good. with the stooption that tbs timetable which
tho Committee insisted upon in Junc-oanaot to not without totni~
noting the study in an incomplote ttsse. I am, therefore, re~
qussting an axtension to April 30, 1974, and havs outlincd in
my lotto: to Dr. Saar: the tsssons thstsfoto and the
state of
tbs study during my visit to Athens on Novembat 7 through
9.
Should an extsnaion be possible. tho Association will prs~
puts the nsoasssry supporting documonta. Should the Connittos
rocouusnd tsrminstion on Doesﬂbor 31. us will submit s final
taport. oopias of all of tho dots. otc.. according to the oon~

tract .

Should you wish additional infatuation, I suggest you die—
enaa the progress in the study as witnssood by Dr. Stars and
3:. Smith during their visit to Athens in August.

It is a pleasure to work with you, and I trust we can bring
this extraordinarily incarnating study to a satisfactory tomplotion.
‘

sincerely yours,
Max

Hrlcis
Baal.

Fink,

M.D.

�</text>
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              <elementText elementTextId="58263">
                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>w, .07

,m .....

V

wuw—r—Ir‘ev-‘vvr-SVW'V

‘

.7

'

r

-

'“‘*' '

"

“""

'

'

A

wnwr-vrw—w—wv-m-w

thaw'v'ﬁ.

W:

«an-Hm

7383~75488

.

www-gmr..~ru

13 Ravi-bar 1973

rmﬂdjn

5.,
~11.

0;
.

1_’J“V1Iv_

r‘l"’§"'

KB!

a-a'wnuﬁ

wm-wmmnn-r

lullagég

Publicattanu Inacarah Offien
Rational salons. lbundntion
Washington. 9.0. 20550

an
vw

1w;

Gontlanan:
so no

I would appruciato having cepins at the £8? Bullocig unit
at:
Depareunnt of Fuychlntry
School of ﬁadiaiua
Rnalth Scianecl Cantu:
8.3.3.!. at Stony Brook
Stony Brook, Raw York 11790

,
M»

5:,
A

mayﬂxﬁc

r4

1"

x
1W

7-;

:ggrf'r'vr-J"?

Thank you.

sinenruly ynuru.

-',.‘1;'

vzu-rwn

Max

Hiluiu

.-

rink,

M.D.

Pratt‘sor of Ptyahtaery

ywmmmmrlwx'vrmv'

�</text>
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                    <text>731~7S7I
13 ﬁavuﬂbar 1973

Dr. Stephen

Stir.

Bivition of Eutectic

and Drug Abuse

Rational Institute of Mbntnl Raulth

Fiahcr's Lana
Rocivillc, Maryland
5600

20852

as:

H3K42-7ﬂw98

Dcar Stave:

I have retutndd from a visit :0 tha-projact "Study of Chroiic
Kanh1sh Uaaro 1n Grcocn" (33H42—70~98) Ind I am writing to bring
you up to date with tha ptagruos.
As you knaw {run your

visit to

Athqa: 1n Augult. the study

callection at data in the tents experiments
in the early spring and the data were analyzad, both in Athanu
anﬁ Haw York, during the summer. A major pattion of the analysts
warn éonn than Dr. A. Liakos unwind in my laboratory for three
vodka in July. -WHon.hc luft, there wet: some tonidual antlynas,
and these Hath couplotad 1n saptlnber and sent to him.
team coupleteé tha

Beginning in Juan, aubjccts warn induetad into the with~
drawnl study and as of November 1. 12 aubjacts hast completed
thc aix~day observation period. I brought the EEG taplt back
to my laboratory on Hovuubct 12. The study tuna in Athens 1.

q.

nears-w

"yr—rm.

v..-

|

aontinuing with the inéuction of subjnctn in thin withdrawal
study and havn set that: tarsut as font additional nubjects,
{or a projactué total of 16. Thay do not baits?! that they
will be shit to ranch 20, but trait that 16 will provide 315~

niﬂieant data.

There have batn no changat 1n the ntaff in staff at Athens.
Despite aw leaving tha Haw York Mbdicnl 0011.31. my cedworkntl.
DrI. Dornbush. Crown, cud Volavkl, aontinua to contribute to
the analysis of that. data.
You should be Ivar. that except for the prsscntation at
thn 1972 818? nesting in Copcnhagnn and ruviuwu at the 1971 ind
1972 tasting: of the ACHP. this material has not bcan palsunted
or publish-d. In ptrt. this rctltctod a reluctance an tha part
of Professor Stefania and.uya¢1£ to prajudga tha data, and I an
culm-

�wanna—nﬁ— h“. 1—H.“ . Y. n-

Dt. Stqphgg Santa

platted

*2~

thtt wt hurl hnnitated. for

7..»

.

w

r. rum...

Wu“ "ﬂu”.r ”pp“,W—

13 Routnbat 1973

our viaws hams undcrgone

changes during the progras: of this study. Profasuor Stefanis
and I discnlaed at length the matter of practicing this material
and praiinionally wt hnvu decided that we will:
(1) truparc a summary for HIKE to supplement tbs
summarits aﬂbnittnd artliar and submit this
tunnaxy with duplicattn of tha data set as
soon as these ate Ivaiidbla.

balicvc that tbs data land thennalvua to
»approxinata1y six to sight prustatutionl Ind
publications in seicntiﬂic journals. and an
'lre prograssing with the preparation of theta
rcporta.
(3) Concurrent with thane two forms cf data ptao~
entntion.*wa believe that the ruports and mate
extensivn data than is stainarily providtd in
journal articles provide a legitimnte basis for
a significant vulva. on the affects of chronic
hnuhidh use in man, and W! plan to nah: sudh a
presentation. (This is particularly important
since the scientists nothing in the Juanita
study appnnutity adopted the utratuzy of pran—
entina their matarial in the pdblic praoa.
instally with regatta glowing tastimaninls of
the curacy of chronit hadhith use.)

(2)

Wk

I balicva that U! will need 1n attention of time if we
are ta attoapliuh the Idéitiannl {our nubjacta. Analyse tha
withdrawal data. writs thn report: to: publication, ate. I
tn aware that at our last Intting in Juae. you: associnta: «are
insistent that the study he annpiotcd by the and of this your.
Shauid this viuv rennin the official position, we will provide

all of thc data availibla to date, including tho with“
értwal dtta, in whttsvar stats thty any be on Decanbur 31.

you with

“a ptafot, howevat, that you reviaw the used for this ttruinn~
tiou, particularly in vita of the fins wart the Gtaok sciontilta havo dong and thc uniquc nature at tbs withdrawal éata.
Wt would raquost an exttnnion of tin» and will prcpnra a bud—
gattry extinct: should your tamuittuc feel that an extension
is feasible. 1 bcliavc that in eatansian to April 30, 1974.
would providn suffieitnt tint to carry out the final phat: at
this study.

�7.
mun;

mum-guru

.
-

m'm'm"m:m'rmww

H17"

.,.,,

.

.v‘..»mw-.g_\——

_V.W.Wm,

Dr. 3tl$h0n_881ra

.w wm—p

WNW“ .1 q-.ry_mwr,_. m."

m-m_-—.u “.-

13

~3—

.-u.-.~,..,ram—w

ﬁGthber

.m. :V‘erI-M'rww'

1973

Yrofousor Stefania tliICd on. administrativh problem
with mnﬁ~that of ch. duvaluntion of the dollar. At their
prestnt rate at uxpeaditurat, 1 d0 not anticipate that the
davaluation will altar ch. budget cignificnntly.

Sincnrely yours.
Max

en:

E.

J.

Gvadwcll

Fink.

M.D.

«w

.7

.-.—

a

A

v“

7,7 .rmw—

,—

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