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                    <text>March 11, 1976

Prof. Dr. £1.14. You Frans
Payohlatrio University Clinic
Div. of Biological Payohiatry
Graningon
Tho.Nethorlands
Door Harman.

It

to tend no the imyroasive annual report
for tho dopartmont at Groningen. It is a fine document, reflecting
the excellence of the studies which have become so well knovn.
I

was kind of you

was

pleased to read that you are doing

EEG

research.

You

should know that our facility has been available for
years, for collaborative studios of the electrophysiology of drug
effects. Should you wiah to expand your studies to include power
spootra or period analysis, I would be glad to discuss it with you.
Please change the address in your
Co11ege to the SUNY address above.
my

more than two

files for

New

York Medical

regards.

Sincerely yours,
Fink. M.D.
Professor of Psychiatry

Max

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                    <text>March 12, 1976

thn

ll

Exner, Ph.D.
Beavcr Drivav

Bayvillo, H.Y. 11709
Dear John.

I read the record of G. Trumantelli, age hT. It in an
mixed frequoncy record without distinguishing
amplitude,
average
features. Eypervontilntion and sleep activation were not done.
In the absence of saizure activity or alov wavea, it is
not possible to support a diagnosis of a poat~seizure sta£e; nor are

thnre distinguiahing criteria for a drug effect.

I trust this is helpful.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

m'.-Wbﬂ'r'vwF-‘€-I

nun

-w—v~=»;\wnp

a:
~

w—-—A

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                    <text>"mu...”

“....r—‘— . u~.——'=.n—»v-——-..m—--w_

.va-WWHW- WWWW-m-.WT— .mu--.My g

May

m.

.....m

'mﬁ'rw- “Feummnww—rw

3, 1976

Russell

R. Monroe, M.D.
6H5 Redwood Street

laltimore,

Maryland

21201

Dear Russ,
Your personal letter describing the opportunities at
the Maryland Psychiatric Institute was most inviting and interesting.

First, as to myself, for that was implied in the letter.
I have no desire to head a laboratory center again, having had the
experience in Missouri and finding that the administrative load kept
me from the studies which I enjoyed more.
best of

The

my

students are recently placed in

new

positions.

Jan Volavka, M.D. has just taken a position in Missouri, in my old center.
Michael A. Taylor and Richard Abrams, both excellent researchers, have
just agreed to go to the Chicago Medical School.’
The ones who may be movable and who come to mind are
the following. Turan Itil has set up a large center in New York at
the New York Medical College. But funding is quite difficult and if
he could be assured of 'hard money', he may consider such a position.

Recently, I met with Jerry Tintlenberg in Palo Alto. He
researcher, but probably does not have enough experience
to take Al Kurland's place.

is a bright

young

Donald Klein has resigned from Hillside and has expected
an appointment in the Albert Einstein College. But Ed Sachar may be
moving, so he may be up in the air and may be interested in a lab

with 'hard money'.

These are the only three with whom I have had some personal
contact during these past few months. I shall keep the opportunity in
mind, and if another candidate comes to my attention, I will refer him
(her) to you.
My

best regards

and my thanks

for thinking of

me.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mal

.

,._..-..

�</text>
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                    <text>4:345”

May 11 ,

Marguerite T. Hays, M.D.
Medical Research Service

1976

V.A.

Washington, D.C. 20h20

Re:

M.

.

David

Fairchild,

Ph.D.

Dear Dr. Hays,

his co-workers

I cannot eecall meeting

Don Genden

and Dr.

Dr.

Mickey——

Fairchild, but I

the

latter

have met
serving as an

ad hoc reviewer of one of my NIMH grant applications. I do know their
work well, and have followed
will interest. They first published about
1969, declaring that the effects of drugs on the EEG of cats could be

it

distinguished using multivariate statistics, particularly that they
could identify different drugs by this method. Tley proceeded to
extend their work with a predictive study and were successful. Since then,
they have published occasionally, and I am not acquainted with any systematic
body of data or systematic applications.
Their work was unusually well detailed; their statistics
was exemplary; and they held a promise for greater applications, particularly
in studies in man. The reports reflected peofessional knowledge of EEG
recording and

statistics.
It is difficult for

me to parcel out the contributions of
therefore to assert what Dr. Fairchild'd
unique, personal contributions may have been. If a number of his reprints
were made available or brought to my attention, I could possibly evaluate

each of the

them in the

participants,

and

light of the developments during the past decade.
I

trust these

comments

are responsive.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

‘

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—v

.uww

w'ﬂ-uw’wr-

V.

-7. A...

.a-.--..

w...—.—,m—.-nm,—.~-mm~a..—-—m-w.————-m‘—.—

May

-

-d

8, 1976

Prof. Dr. Tetsuo Fukuda
Neuropsychiatric Policlinic
Doshisha University
Kyoto, Japan

m‘w-

Dear Professor Fukuda,
-,,.........,.,.,.

.

.
..y~—-W-

mamw

..u...w.'w

mwmwcuw

mW'

-—1

mun—r

__,_._,

g

.7-..

It was kind of you to send me the reprints of your
work in lectroseizure therapy. I found the papers of interest
and am pleased to become acquinted with a body of experimental
work that is new to me.
Professor Jan Otto Ottosson has acdepted the responsibility
to develop the panel on EST for the next World Congress of
Psychiatry. I will write to him shortly and shall bring your
contributions to his attention.

It was indeed good fortune that arranged for me to
meet Professor Mitsuda on the sands of Waikiki. I have spoken to
Professor
this week and told hfm of your letter and my
meeting with Professor Eisuda. He recalled the meetings in Kyoto

Itil

with great pleasure.

,,
.
.7.

v

in

I do hope that we
Hawaii next year.
My

regards and

my

will be able to get acqauinted (again
'

thanks for the papers.

Sinciunly yours,
Fink, M.D.
Professor of Psychiatry
Max

7)

�,...

v-um-wvung

7

w-W—lr

“—VW

.

"haw...—......

.pmmwy was—Wu--.~avm muw'mw‘w-W _‘

May

7, 1975

Professor Hisotashi Mitsuda

Osaka Medical College

Osaka, Takatsuki, Japan
Dear Professor Mitsuda,

It was a good fortune that arranged our meeting on the
sands of Waikiki, and I thank you for the recommendation to
Dr. Tesuo Fukuda. He has been so kind as to send me some of
the reprints of his work, particularly the work in electroseizure therapy, and I am pleased that these have given me a
better idea of the excellent work that has been done in Japan.
Professor Jan Otto-Ottoeson of Sweden is organizing
the panel on EST at the forthcoming World Congress of Psychiatry
and I have sent him the suggestion that Dr. Fukuda be consdiered
among the participants. I am sure that he will let Dr. Fukuda
know directly of the development of the panel.

I look forward to meeting

you again in Hawaii in 1977.

Sincerely yours,
a.
.
..
.

‘mwrmmmnwwm

.-v-~

\
rwv-

WWW

"pm—Wu.

».~.w.w—w_.—w—

Max Fink, M.D.
Professor of Psychiatry

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1","

m..-—.-_-»-...w- W,—

m.‘

e. \e— -. unaware“ .uﬁw—‘u-“emnn’- Y...“ «an m. e: "—wnw—rwv‘“w‘—'ew u.

—.,.

.V

"-‘a. “u. ‘,__.___._..___....._.._...4

May 17 ,

“.7.

.

.4

1976

Dr. Laurette Banter

#23 Ben Oaks Drive

W.

Saverna Park, Maryland

21146

Dear Dr. Bender,
The American Psychiatric Association has established a
Task Force on Convulsive therapy and as a member, I have been

literature for a statement of the efficacy
in a variety of conditions, including the
treatment of childhood psychoses. I have been referred to your
work as evidence of the usefulness of seizures in children and
have found it difficult to find the citations. I would be
grateful for any reprints or reference to published material
that you may have available that may assist in this effort.
asked to review the

and

safety of

EST

Dr. Hegeman was kind enough

she, as do 1, sends her regards.
Many

to give

me

your address and

thanks.
Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

�</text>
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9w?”

May

Professor Dr.
9

22, 1976

Mitsuda
Kitazono-cno, Shimogamo
H.

Sakyo~Ku
606 Kyoto Japan

Dear Professor Mitsuda,

It

of you to send me the fine volume of the
biological bases of metal illness, held in Kyote.
I had heard much of the conference, not only the excellence of the
papers and the discussion, but the generosity and hospitality of
was kind

1973 conference on

the hosts on Kyoto.

psychiatry,

is an interesting milestone in biological
shall treasure it in my library.

The volume

and I

I thank you for your thoughtfulness.
Wm—n-m.

&lt;

Sincerely yours,

xwvwW

w
9‘!

aw,"

..
a.

.,....

n..........,.7v.s...

,..
Nu

.1.

~

pr...

‘.

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>Fur...

,

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,

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‘1

‘

.mw “..meﬂy- 'wr‘l ”may._ .Yﬁvm’wmxmu»...n-r-—~»—.—--—W"'*‘W
.

-

th 25. 1976

E

William Dent, M.D.
A.H. Robina Co.
1&amp;0? Cummings Road

Virginia

Riohmond,
Dear

Bill.
I tried to find

Dr. Tisdalo at the Florida meetings of
are interested in continuing studies of
2277 and woula be grateful if you would send me the
latest
‘

ECDEU,
AER

23220

but failed.

invontigator's
my

W;

summary and proposed

protocols.

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>Flown. v'v—wur ...

~~. -

,

-

...\

-——

wwn-v-IyV-V‘wv‘ﬁ'mwrxt—I—r-m

i.

v.

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v

w "—wwpa- -W4.-——.-W-w.

mom—“Tn ~y-wmm~~.—&lt;

'vn

.
'w

wun~«m_n.v-.~

May

Joseph Jeffe, M.D.
Dept. of Psychiatry
College of Physicians and Surgeons

Columbia University
New York. N.Y. 10032

27. 1976

if

Dear Joe,

about

Thank you

my

for your recent letter

visit. I did

another opportunity to meet the

merit, that of

EST.

While

and

the nice

comments

enjoy the session and hope that I will have

at the

APA,

I

staff

on the other

had an opportunity

issue of

some

to chat with

Dave

is actively involved in studies of lithium maintenance
in a large clinic, He tells me that he has therapy responders and
non-responders, and the paper he geve on this subject was quite good.
I suggested that rather than having you relate to me at LIRI, with

Dunner.

He

all the distances involved, would he not prefer to work out language
measures as change scores and even as predictors of response to
lithium? He seemed delighted and I commend you to him. As I know
him, he is an earnest and herd worker, quite forthright and honest,

”vand

I

would be delighted

to

work with him.

If I can be of further help, let
collaboration works out.
My

me

I

know.

hope

the

‘

best regards.

Sincerely yours,

m:

Fink,

M.D.

Blp£. of Psychiatry

—»

-—-

mm.“

�</text>
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                <elementTextContainer>
                  <elementText elementTextId="106991">
                    <text>7.“... _,_ _ WW.

”“2 ..., v. - w. .,.......,.—-. ,r.

.....\r..............

»-~m~-:—w‘-z--r-—.m

”av—"WWW”.

-.,,1. .— q...

.- _.. ...

.

e,m .

..

,g

w...M...a.“ w. .

v.

May 27 .

.

-

...

w.

.

..

.7

”.7.

..

..

.

n...

v”

Dyna—um,

.—,...—..—.\...~"WW", .7...

,vv

.

...—.--....r...._.:vr

1--..”—

1976

Dear Stan,

It

has been some time since

is well in Baltimore.

Our week has

communicated.

we

fallen into a routine. I

I trust all

had a research fellow

Italy with me this past year, and he has left. He stimulated
our interest in anticonvulsants and we are now studying these actively.
from

We

year.

The Greek volume

I am,xeeting another
We

studies and demonstrated
studied. We think EEG can

have completed some blood level/EEG

the very high correlations for the drugs
be used where blood measures are hard to

are developing

is about

60%

on EST.
some

we

come by.

done and should be out next

ties to Hillside Hospital.

Enclosed

is a paper sent me by one of their staff who is interested in Joining
BURY.
I cannot evaluate the merits of the thoughts or processes. Can
you give me an informal opinion of this work?
Joe invited

He's looking for
My

new

me

to

P 8

for a lecture

challenges, and so

em

I.

and we had e good time.

best regards.

J

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

\

�</text>
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                    <text>May

Dear Dr. Goldfarb,

Enclosed

is the reprint you requested. The problem that
APA is an important one, deserving of the

you addressed at the

detailed

and

28, 1976

controlled studies

which have become the hallmark

of recent research efforts in this country.
of

my remarks was in part occasioned by the
Task Force on Convulsive THerapy held earlier
heard from a number of EST practitioners that they

The burden

hearings that the

APA

that week. We
were uniquely successful in

treating thousands of patients without
succinylcholine, barbiturate or anesthesia, without memory loss or
other discomfort, without missed seizures or panic or failure of
patients to return to treatment. In tine with that experience, your
anecdotal report seemed to be of the same nature—- observations
without a comparison or control group, and without evidence in
the report of detailed attention to the problems of consent by
psychiatrically ill to procedures that are clearly experimental.
Further, since you were willing to push the limits of the number
of seizures beyond those in the literature, it seems essential that
peer review of the protocol be included in the report. If there was
peer review, then a comparison group would have been essential; its
lack suggested that peer review was cursory and perfunctory~~ surely
not acceptable in a procedure as potentially damaging as induced
seizures.

One other point-- your text suggested that the increased
frequency of seizures was an attempt on your part to reduce hospitalisation in a situation where you were overwhelmed by a large number

of patients and an inadequate number of personnel to care for them.
This is an inadequate justification for a research effort unless
duration of hospitalization and aftercare are part of the project.
In the report, the use of drugs after and during EST seemed uncontrolled
and therefore to nullify the significance of your observations.
There is need for a controlled study of multiple EST, and
I hope that you will undertake such an effort-— with regular EST as
a comparison group, peer review of the protocol, and consent procedures
that are well defined. Good luck !

Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Max

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                    <text>MW~

~ w—"q—w—gw

-»-.

rw-vww

"vu

__.‘.

.
"gm-"w

.1» w.

k

August ’4. 1975
Ms. Maya

Pinea‘

h72h 32nd

Street,

washington,

N. w.

20008

Pines,

Dear Ms.

m.

D. C.

for alerting me to the latest issue of Saturday
to the fine article that you wrote. It does capture the
excitement of our work. ORG 2766, the long acting peptide. will be in
clinical trial in Europe and the U. 8. this winter. It is going through
human toxicology trials now. Among the early tests in the U. S. will be
assays of its effects on the EEG and on memory function, and in elderly
patients. The studies of ACTH h~hlfin the elderly are in progress now
at New York Medical College and Néw York University, and soon will also
boast the Hillside Hospital in New York.
and

Thank you

Your

article was well written

and described the state of the
you.may wish

art well. Perhaps, among your other writing assignments,
to tackle another interesting story.
The human EEG has been

studied since

its first

published

report by Hans Berger in 1929. During these hs years, there have been
many applications, including some of those described in the Saturdgy
Review. One interesting development which is not widely known is the use
of EEG methods to find new drugs for clinical psychiatry. Since the first
descriptions of modern psychoactive drugs in the early 1950's, most cons
pounds developed by industry are based on their similarity to an ettablished compound, or to their effects on animal assay systems. The first
methods produce "me, too" drugs; the latter are often inaccurate, for
someilIuInnds that are psychoactive do not satisfy the animal assay
‘

criteria,

useless.

and some compounds

that

meet assay requirements are

clinically

quantitative EEG analysis has been successful in providing
a classification of psychoactive drugs that is based on neurophysiologic,
The

not on chemical criteria; and new psychoactive compounds have been found
by these methods.

�‘V’nwr

wuss-r:

r‘wr‘l-YW'

V

7.77 ._

.. nu war

WWW‘IC'W‘wummmw—VVnruwman-rm—w

"1. war "W"‘m‘ -wn.w.~A—a-.r-a—mm.w~rnrw—qw—~nwr-sm—r—mvw

M's.

Maya

,

g
i
-

rmr-~

4

—:.-,

W;

cm.

y!"7!f‘l‘7"*‘

.

qmiuvw-prw—u.—

-—.-1-.-

wmawW..—V.w-ywu-.m

Slit/75

-*

EEG methods hare also been extended to estimates of the half
bioavailability of drugs. This latter use has become important
as the FDA has demanded that drugs from different manufacturers meet
stringent standards of safety, purity, and availability to the patient.
These studies show an intimate relation between changes in
brain function and behavior in man. Some physiologists describe the
electrical activity of the brain as a 'matabolite' of brain function,
reflecting its underlying activityh.
The quantitative analysis of EEG is distinctly different from
the clinical analysis of EEG.as is ordinarily done by neurologists. It
depends on careful control of the setting of the experiment, and measure—
ments or the EEG, using digital computer analytic methods. A review of
these developments would be timely, for it will provide the lay reader

life

E

Pines

m—N

and

with another

View of brain function to complenont his information of
depth electrodes, chemtrodca, biofeedback, and sleep research.
-

.

I

am

enclosing two reprints describing this work, one for
that may give you a better idea of this topic.

1969, and one for l97h,
Again,

have an opportunity

congratulatiOns on a fine report. Perhaps
to meet'to discuss this interesting project.

my

we

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Max

MF/mr

Enos.

will

,

7

Wm, e..-

um

v.7. V...”—

__

�</text>
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                    <text>-

ewewwwm.

q...—

V...

,

Ausust 7 . 1975

.—

Wm.”

lvwrwmr

v—mrvqum

-

r

.wm

Ivan

W.

Sletten,

M.

D.

Professor and Institute Director

School of Medicine
Department of Psychiatry
University of Missouri-Columbia
ShOO'Arsensl

Street

St. Louis, Missouri

63139

Sletten.

Deer Dr.

I am replying in a formal manner to your letter of inquiry
regarding Jan Volarka, M. D. It is not clear for what position he is
being considered, but he is an excellent candidate for the position
of Director of the Institute.
Dr. Volsvks Joined

~College in the £311 of 1968.

staff at the

my
He came

medical
as a well-trained psychiatrist,
New York

neurolOgist, and electroencephalographer, with extensive research
and
experience. Within a short time, he established‘collaborative When
independent research projects in the areas of his competence.
I left the College, it use a pleasure to recommend him to assume
responsibility for the EEG programs of the Depehtment.

In addition to mastering the English and Spanish languages that are necessery for his work in New York City, he has become
fully‘sccredited in psychiatry by the American Boards and has become

licensed to practice in

New

York.

Dr. volevha is a keen researcher, well read and well
trained, capable of independent and collaborative research. He is
an excellent statistician, in addition to his training es s physi—
cian. He is well liked by his co~workers, is able to establish good
relations with patients, and an excellent teacher.
,

�“we...” , ".1. ,F....._,"rm..v——“m.1

.

.-

-

v. _ . ...- "vow-n.

,..._.

w; ”Av-.3“.

arr—v, --——~—~-—r-”nun-‘4
V

.

.-

a WWW'”v.w“ﬂung“. 4

Mn;

r

4.w wan—«T. ﬂew -»a um u..."a»

‘1‘.

-WW—«.—

,
4.,

.

r
A,

,
_,

«Trump—y;n..—‘mriv.,,,ne.l.,

w‘rivl'vm‘ﬁr

w

urn:

a

inr“

Ivan

Sletten,

W.

M.D.

-2-

.

8/7/75

we have published together. and in this relationship I
him critical, independent, and e perceptive student of
found
have
the literature. I know his family, and while it is difficult fer
me to conceive that his wife would be willing to share the rigors
of St.Louis, she is an outstanding student and athlete, being a
world champion in tennis and skiing. He is personable, Joviel,

herd-working, sensitive, and enthusisstic.

He is an outstanding‘candidete for the position.of
the Institute and I commend him to you for that posiof
Director
deem it an honor to hive him assume the title which
would
tion. I
I relinquished some years ago, with the'full knowledge thatofhis
training and experience would serve to carry out the type
clinicel—electrophysiologic investigations_for which the Institute
has become known under the aegis of Turen Itil, George Ulett, and
myself.
.

.mv-«W._—~.~l_m,_..i

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

*1!

�</text>
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                    <text>‘7": ,.._..v_

Auzust 8. 1975

Mrs. Marilyn Freedner
28 Strathmore Road?
Great Week, New York 11023

~

‘
\K‘J

i

Dear Mrs. Freedner,

I thank you for your
gagigg orticle.
So

comments on

the Saturday

far, the experimental peptiies are in trials in

seizures (convulsive theraPY) and
in elderly patients with 'normal‘ forgetting. Should these

patients

fOIIOVing induced

continue to be successful, I have every expectation that the
experiments kill be broadened to other population samples. For
the mnenwhile, the rules of drug research prohibit trials in
individual patients with disorders outside those for which

trials

have been approved.

Sincerely yours,
Fink, M. D.
'Professor of Psychiatry
Max

;

hFer

�</text>
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                    <text>August 11 . 1975
Mr. Edward H. Meyer
135 Godfrey Road
Fairfield, Conn. 06h30

Dear Mr. Meyer,.
comments have

receiving

ECT

for your inquiry and for letting
in the Bridgeport Post.
quoted
bee.
Thank you

The memory

me know

loss which has been described in

some

that

my

patients

'

can be reduced by a number of maneuvers: the proper selec—

tion of patients for treatment to include only those with depressive paychoses; the proper placement of treatment electrodes; and the treatment
of those patients who do experience memory difficulty with new, memory
enhancing peptides which are now in experimental study. It is not clear
from your letter whether you are asking about treatments to be given
(where prevention is available) or treatments that have been given
{where therapy is limited).
'

Treatment for any illness is not alggys effective, end so
with
convulsive
is
therapy. In comparative studies of ECT and drugs,
it
“the treatment results, even accounting for memory effects, are uniformly
_better for certain types of illness than when these patients are treated
by drugs or psychotherapy.

I do not know what declarations others may make; in my lab—
oratory patients and their family memters are advised as to the limitations and possible advantages of any treatment we may undertake, and consent is obtained from patients and their kin.
Medical custom.is a much stronger inducement to medical
practice and behavior than your reference 'under law' since the law is
what the courts and lawyers wish it to be; medical practice is respons—
ive to the ethical standards and morality of the community in which a
physician serves, and the hazards and pressures of the informed and

laity.
I trust these

uninformed vocal

comments

are responsive.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF/mr

�</text>
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    <fileContainer>
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                  <elementText elementTextId="103944">
                    <text>kW

'

August 21, 1975

Fritz A. Froyhan,
Editor-1n—Chief

24.13.
J

Camprehonsivu Psychiatry

washington, D.C.
Dear

.

f

20009

5

Fritz,

E

Ed's

letter of

August 12

is in error. Chnrles

Shagass in program chairman fbr 1976.

with his carbon,

i can't

Since no

latter

cans

to the

i

i

nnavnr.

Whatever happened

i

.

book reviews!

—&lt;.v&lt;r‘.,,v_.",

My

v

Nov—.0.-.—

regards.
Sincerely yours.

vm

_‘

Fink, M.D.
Profbssor of Psychiatry

Mix

MF/mr

�</text>
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w.*m,wm\w_

"em—,m—m»..u—.w—....,..

g, ﬂﬂﬁ"

u

r"‘("—."Yulrvaw

3—H-”

‘

Alvin 8. Bernetein, Ph.D.
Associate Professor
State University of New York
Downstate Medioal Center
Department or Payohiatry
hso Glarkson Awenue

Brooklyl,
Dear Dr.

New

York 11203

Bernstein,

quentifioation method is preferable to eyeballing,
outline in your letter of August 6 seems quite
the
sophisticated. I think the method will show changes in brain funcof your system, you
tion, should such changes occur. As a test and
closure and hyper—
could establish the effects or eye opening
show big changes in
should
two
thst
simple
procedures
ventilation,
EEG. If these are shown, then the method any is useful. If these
are not evident, then I dug-eat you try some other system.
a research
It is not possible to predict the actions ofmovement
behave
Brownian
or
like
seem
to
committee
they
grant
the random discharges from outer space, but the methods you outline
are not 'gross or simple—minded'.
and

Any

method you

-

Good

'

luck!
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

MF/mr

Yum” .F—m—n—w‘wﬂpr...“

�</text>
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                    <text>wrﬁm

-.v-~v

&lt;u.”yv-v"~vr~v‘

”Rm-unm‘p‘,w-ww-.. “mm"."wv. ,....—.—_,__.,._m-.~.~.«n ,.
——-

September 8, 1975

Stovnn R. Hurnad, M.D.
College of Modicino and Dentistry

of

Nov

Jersey

Rutgers Medical School, Dcpt. of Psychiatry
Univorlity ﬂhighta
Piocatsmuy. New Jersey 0885h
Dear Dr. Harnud,
We

in the

would be planned

Amnrican

EEG

may do your

rccommnnd you

for

mamborship

Society.

«would you

I

to

please Iond.mo a capy of your

CV

to that

record Justice.
Sincerely yours,
Fink, M.D.
Profossor of Psychiatry

Max

MF/mr

�</text>
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                    <text>September 9, 1975
Mrs. Judith A. Cooper
19 White Cliff Lane

Neseonset,

New York

11767

Dear Mrs. Cooper,

misunderstanding. At the
time that Mr. Irwin interviewed you we had not yet clarified,
whether the position would be part— or full—time. That has since
been clarified, and the position that is available is full-time
at-the Long Island Research Institute.

I regret that there has been

some

we have advertised in Newsday this past Weekend and we are
in the process or awaiting replies, which will be reviewed by
a committee, and those candidates who seem to meet our criteria
will be interviewed.

now

Should you'wish to be considered for a full~time position,
I should be happy to have your credentials reviewed, among the
others, at the committee's meeting next week.
I hope that the facts are a sufficient explanation for any

misunderstanding which

may have

occurred.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

MF/mr

�</text>
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-

-

.

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September 16, 1975
John

J.

schwab, M.D.

University of Louisville
P. O. Box 1055
Louisville, Kentucky

140201

Dear Dr. Schwsb,

Nikolovski,

I

am
M.D.

pleased to write e

letter of reference

on

behalf of Oliver

Oliver Joined my staff at the New York Medical College about 1968.
after his training at the Missouri Institute of Psychiatry with Professor

Turns

Itil.

'

,

Dr. Nikolovski was assigned to outpatient clinical evaluations of
psychoactive substances at the Metropolitan Hospital. The initial exper—
iences were difficult, since the population was largely lower—class and Spasish—spesking, providing all of no with serious handicaps in the evaluations.
Oliver did well. however, and became a principal assistant to Dr. Jovan Simeon,
the unit leader. Together. they completed evaluations of some antidepressant
and antianxiety compounds in these outpatients.

new

V

In 1970, the Department chairmen, Dr. Alfred Freedman, asked that I
transfer Dr. Nikolovski to a newly established community clinic, where he needed
a principal psychiatric therapist. He has continued to do yeomen service at
the College in this position.
Lately, he has been helpful in evaluations of a putative memoryenhancing compound, studies that have been undertaken by my co~vorker, Rhea

Dornbush, Ph.D.

Oliver has extensive clinical experience.

He

is intensely loyal,

dependable and reliable. He is meticulous in his relationships with the staff
and the patients. He is personable and likechle, although at times he appears
ohseqnious.

training qualify him for that posi—
tion described in your letter as functioning in an outpatient clinic with 255
of his time dedicated to research. It is a pleasure_to recommend him.

I believe his experience

and

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

.

.

�</text>
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                    <text>;-—~-Fw—v—.mvw

»

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.

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‘_

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my- “p-..“r.

7

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ScpteMber 18, 1975

yr.

Homer A. Chamberlin

’Dundoe, Oregon

97115

Dear Mr. Chauberlin,
The procedures you request on behalf of your wife are in
experimnntal trial in rolativnly haalthy and uncomplicated aldnrly

pat‘inta at this tins. Should the results show the compound to be
safe and have thornyeutic value. it will then be tested in more
severely ill patients.
I truly ragret that we do not have thn facility to treat
wife
at
this tiio, nor do I envision such facility earlier
your
than late in 1976.
Thank you

for your inquiry.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF/mr

.

V..- “ma—~77 V...

�</text>
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                    <text>WP”

L‘s.“—

(r v—A»!

um

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,

,

mm-

,

,

mm“ mm“ w-Y_-an.
. », —

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v

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,

,

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F

t
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E

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g.

Soytenbor'BO; 1975

McAllintor, M. D.
Corresponding Socrntary
Amarienn Board of ElectrOencaphnlography, Inc.

M.

A.

.

3101 Kyle Awenuc North
Golden Valley, Minnesota 55h22
Deni Dr. McAllister,

I am pleased to-support the application of
as a qualified olectroencaphalogruphor.

Dr. Gerald Perry

I have known of his work for more than 20 yours, for ha
was Ictivn in clinical practice of psychiatry and EEG shah I firat
can: to the Earth Shore of Long Islnnd. Kb is a fin. clinician,
and an excellent neurologist; A: part of his practice, he has maintained an active interest in cliniogl EEG, being one of the principal
consultants in our community.

Lately, I have collaborated with him in a research atuay
in which EEG mcaauxes are integral, and I havn found his Hork.most
helpful and his cooperation axeellant.

I

recommond him

vighout resorvution.

Sincerely'youri{*'
Fink, M. D.
Professor of Psychiatry

Max

MF/mr

�</text>
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                    <text>r--vv-r—.~.v—-w~v~“

mywmvnz

W”
Michael Taylor,
Max

Fink,

M.

I

D.

am

sorry that Abba turned us dean for he is the most
in the field. However, nyle Miller is a pleasant,

&amp;ynamic worker

friendly researcher who

,and has done
‘nature.

H3

October 3; 1975

M. D.

is

came

to psychology late in his career

interesting research from a psychophysical
a careful worker but does not have the sophistica-

some

tion or the experience of Kastin.‘ I don't bclieve that he would
interesting as Dr. FlorﬁHenry who.apoke

be as challenging or as

today.

‘
»

I think I
~.v-

In“

i
L
E

E

MF/mr

would pass on

this invitation.

‘

�</text>
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                    <text>Joseph Zubin, Ph.D.

Chief of Psychiatric Research
(Btamotrics)
annrtnont of Mental Hygiene
New York State Puychiatric Institute
722 What 168th

new York, H. Y.

Dear

Street

10032

Joe.

I think thn volume, "Contemporary Sexual Bohsviar"
should be issued in paper-back. It is a well~collectcd not of
onuayn, not supersednd by recent rasoarch. The topic is of
perennial intoreot. I asked the advice of our resident anxologiat,
Dr. Richard Green, and h. thought the valume of sufficient merit
to be reissued.
should

(Incidentally, he is not a

v. propose him?)

mambcr

of tho

APPA

-

Congrntulations!
Sincerely yours,
Max

Pink,

M.

D.

-Pro£ossor of Psychiatry

NF/mr

�</text>
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                    <text>October 3, 1975

Fred Quitkin, M.-D.

Hillside Hospital

P. O. Box 38.
Glen Oaks, saw York Ilooh
Dear Freo;
5/?
Enclosed is a copy or the 1976/77 Program Statement and
Budge£?Requcst for the Division of Therapeutics of the Long Island
Research Institute. I think you may find this useful. The program
is set up so that we will develop all five laboratories of this

division during the next four years.

entiinterest butIthese

theiprogram.'
.
.

,

W

whether

I

The
may be modified by
"

on a more personal

knew a Enr. Fred

matter,

my

Quitkin" and

missions reflect my presthe scientists who Join

wife asked

when

me

yesterday

I said I did, she told

that your son.£s in her class. He's quite a charmer and she
looks forward to ﬁeeting you when you visit the school.

me

u.

.

‘\

'My

A

,:

regards,

“5‘ij

Sincerely yours,

v...“

.

/

l

i

MF/mr

Enc.

{1

K.

Fink, Me Do
Professor of Psychiatry

max

r

*

�</text>
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                    <text>{I

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Octobor 15, 1975

Carol Chrintinnlon. R.£EG.T.
Lib. lourolngical Institute
168th strut
won
no

EEG

Rev York, N. Y.
Doc: Minn

Christiansan,
Tho

fbr

EEG

10032

Mbtrapolitan

technicians has
I

EEG

boon

wallnttor 1ndie:tcs that a school

establishcd at Prosbyterlnn Hospital.

would be gruﬁotul

tbr ‘ny description of tha course,

requirnmnntn for adminsion. and vhother the course 19 part-time

at full—time.
Thank you.

Sinecrcly yours,
Fink, M. D.
Profbasar or Piychiatry

Max

HT/ur

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                    <text>w... .y.

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a“‘|&lt;'&gt;V—-—'V'—-wlr-WW'V‘VWWW‘thru—IW‘

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4.

October 16, 1975
‘ﬁ-VPFEIWm-vrw‘

v.
&lt;

.

Richard

m

V.

.J

M.

Suinn, Ph.D.

Professor and Associate Rhea
Depertnent of Psychology

'WW‘

caloriﬁc 8$e$e University

ibrt Collins,

vs

Colorado 80521

r--r‘&gt;—'1.I$Vt

WNVr-‘v

Deer Dr. Suinn,

In checking
you requested pernieeien

my

records I find them e few years ago

to reprint

one of our papers on

narcotic

entasoniate in a volume ”Innovative Therepiee: Critical Contri-

butione."

I don’t recall seeing the book,
ask whether
whether

we

and

this publication did indeed appear;
may have e copy for our library?‘

I

em

and

writing to

if

so,

Sincerely yours,

ma, “0of D.Psychie$ry
m
Protester
MFYur

‘

~wﬁ

w...

.V,

“7......

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�a
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‘

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nun-7r,-

"urn-WWIV

v.
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am..."

V

”wwwmmmﬁ

WW...

v

785-5055.

January

236th, 1973

8m.

31311“ M.
Phoni.
Profbcsor and Assaults: Head,
Dapurtnpnt of Piyuholoar.
Colorado

Silt: university.

For: Genius.

001m

30521.

Dear Doctor Evian,
Hy associatns :nd I are planted that you tr.
‘.
considering our report tar tn: boat of readings titlad
”Innovnxlvn Therayict: Critical Contributidns”.

I u: enclosing sh. signsd rolonn¢

of tun rcprint you requastcd.

and two coping

Since that report‘vna written v: have updtted our
axpcricnco. 3nd I nu enclosing Eva c0910. of thc latent
varsion of our report on these therapies. This varslon
has beau Iﬁbulttod tar pdblieatian, but has not ynt
tpwoarcd. I an canfidnnt that v» cgn dbt;1n s rolonso.

I nut. thaﬁ you ac not considnr ruyultioc 2b:
aur contribution. at the laalt I would oxpcct an editor»
ligand cony of the final publication for each of thy authors.
I trust that thin vauld‘bo’ponutble.
While

Singercly yours.

Mn:

rink.

M.D.

Profoaadr of Paychittry
10/13

Incl.

�</text>
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                    <text>“mum—«a.

n‘v'v.vmr&gt;~ww—~W‘mvw'wk --‘ “mm." ~&gt;~—nv&gt;an.~rvl‘—m-Flr
~

1-—«W:vwnwpw.uw.w.nw. www.m‘qm
~

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M*mmuw.mnm-

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27-1.}

ml"

v+r

53mm
:}t£9

October 16, 1975

m-wecv-

r

.V-

Int"

«W‘Wzr‘

r—uy

.

Millicent K. Trnchtcnborz. Administrator
Ficldston Lodge Huruing Hour

Ks.

666 Kippock garnet
Bronx. ﬂew Yomt 10h63

Dear Ma. Trachtonborg,
Mrs. Bonus Durbin scrvad as a research nurse in the
York Modicnl Callas; Division
in Motropolitan Hospital from ayproximatcly 1969 until I left in
1972. Thereafter. she eontinnnd to sorv. my successor, Dr. Richard

ansrtannt of Psychiatry :3 thn‘lcv
Rnsnick.

I found hat pernonnbln. eoapcr.t1vu and bright. 3h.
a fine nuts. and V‘s chin to astunn responsibility fbr thn admin—
istraxion of drugs, the rating or patients. :nd the kneping at
rolenrch racordl fur a number at my studioa.
13

Whnn

I left

309 IOrk Mbdical College

Join no in Stony Brook and

I rogrcttod thut

I invited her to

she did not do no.

I trult this 1: hslptul.
ﬂinaoroly ycura,
Mu Fink,

M. D.

Professor of Psychiatry

MF/nr

2

�</text>
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                    <text>tv—xw

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WW
AOctober 16, 1975

M. Schneidor. Ph.D.
Senior Editor
Raven Press

Diane

Awenue of the America:
now York City 10036

llho

Dear Dr. Schneider,

I have never studied cocaine, and while I would be
follow
in the historic steps of Sigmund Freud, I cannot
to
delighted

do so.

My

present commitments are too

mneh

to beer as

it is.

I have not lbllqwed the latest cocaine literature, but
incidental.resding in the psychiatric Journals, I don't think
there's sufficient new infbrmntion to warrant even a systematic
review urticle on this very limited subject.
from my

nr

~i‘4'1/

Ira-7.,“th

to reed the volume put together by Dr. Eyck,
"cocaine Papers," published by Stonehill. Dr. Eyck is a well-trained
physician and he was unsble to put together a very useful volume.
A copy of my review of his book is enclosed.
You may wish

E'v'r-

Thank you

for thinking or

me.

Sincerely yours,

pr“;

.~

,

n«;.n

,
A

w

rrn

Fink, M. D.
Professor of Psychiatry

Mex

MA

32%

cm,

“m

“W"

'av

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�</text>
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                    <text>0.77“

Catcher 22. 1975

David do ﬂied, M.D.
quortmsnt of Pharmacology

Uhivoroity of Utreoht

VandeLoen 6
Utrecht , Roll-ad
Door David,

weeks ogo wo had an interesting visit from
Dr. Urban, who presented some interoeting data from your laboratory
to a amall group of my coworkers; end we enjoyed his visit.
Some

I have reoeivod an inquiring following on the roport
of your work which appeared in the "Saturday Review." I enclose
tho inquiry and oak vhnther you or your associates can enlighten
me and Hr. Rnduna. I would be grateful for your advice.
When next you coma to the U. 8., I would be delighted
to visit the galleries again with you. Let me know when you are

coming and

again.

it

will give
My

me

an oxouso

to visit

now York City once

best regards,
Sincerely yours.
Fink, M. D.
Professor of Psychiatry

Mex

MF/mr

Enc.

�</text>
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                    <text>"7.,” ,,

~--—

—

.v.-. ,,

...«_w-..e,~J-_ rum'vxuifﬁ

,

uvwamrwv“WNW

.mrﬂ...“ ”‘37..

v,

w.” W... a...“
1.7

any n»... in

...w

rrwwuvwmuw'«-~.——..

‘w.

»

‘. YT...

“

.‘..,‘_._r-,

Octobar 22, 1975

PM

L.

mm. “.8.

Central E1¢nnnt:ry'8chool

Fourth Awunun &amp; Bueand Struts an.
8%. Cloud, Hinnosot: 56301
Dear Mr. Badman.

unknown

I rugret to any tha£ the ansvnr to your quastion is
to no. I do not know if Ill. und (bugle children differ

in their lavnla or

I
in Holland.

ABTH.

ham. sent your

letter

on

to Prottssor

David doWiod

3. in the principgl invoctignmor of this

and perhaps ha

will

haw! an unswur

program

fbr you.
Sincerely yours,
Pink, M. D.
Profbasor of Psychiatry

Max

MF/ur

.10.“, ,.

,. .

.«rw

,

,4

..

.

.,

�</text>
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                    <text>.».Vt{m".\'

mm:

mnwrr-

:wwn run-r www- I'vw-K w-vr

v

-

v-vvv—rv-mv u-"v-

.r.

-

.

-~

"‘~a.»wm;.w 4%; r

.r-

W
October 23, 1975

_

William 0. Clark, Ph.D., Editor in Chief
Principles of Psychopharmacology
Chief, Psychopharnacology Research Laboratory
Veterans Adnﬁniatretion Hospital
Sepulveda, California 91333
Bear 3111;
The following information describes the training program
available in this department. The training opportunity is in the
Laboratory for EEG and Human Psychopharnacology, and in the Division of
Therapeutics of tho Long Island Research Inetitute. I an the director
of the program and member: of the staff are lieted below.
we have generally worked with Fellow: who Join the Division
for e onenyear period, or longer. The work is principally a research
opportunity in electrophysiology as applied to paychopharmacology and
candidates are encouraged to undertake individual research projects,

which are funded by
’r"

overseas.

my

or.

this Laboratory.

Stipends are available, particularly for candidates from
’

.,,

is

application of quantitative EEG
to pharmacokinetic studies. classification of the montally ill,
The emphasis

«mm

.7
.A

'ra'l-mpvvl

-r-

.

on the

methods
and identification or new,peychoective substances. The work is focueeed
on normal volunteer: at the University and in patient populations at the
Long Island Research Institute. Both laboratory and clinical work are

included.

wmwuwm-mwrv

_.
u":

For physicians, a requirement is an ECFMG, or a license to
practice in the State of New York, if they wieh to participate in the

clinical program.

.g-rwvw

Wm-

The only language requirement
members of the staff

the studies; however,
and Spanish.

is that English is used in
are facile in German, Italian,

�Willi“

Go

ﬁnk,

Ph.D.

10/23/75

“’2"

in...”

...,.

l-

.

H.

A.

U...”

..,.,-..

‘Jn‘n’-

do not give e degrse for this work, but candidetca who
hers completed two yeere of resiasney training cen obtain credit for one
year toward their Board requirements through this program.
we

3-,

The

present

numbers or

the teaching staff are:

”I“,
m
Professor of Psychiatry
MI Ds

Whiter

G.

Bennits.

M.

D.

Visiting Research Professor (University of
Alexander

Genoa)

M. Don

Asaociete Professor of Psychiatry
Bernardo Heller. M. D.
8r. Reaesreh Scientist
Long Island Research Institute
Michael A. armor; M. D.
Aeeociate Professor of Psychiatry
Richard Abrams,

M.

D.

Associate Professor of Psychiatry
Timothy

M,

24.1)...

Research Scientist
Long

no.
'

Island Retesrch Institute

I trust this intornstion is helpful.

volume!

Good

luck in your

Sincerely yours,
Fink, M. D.
Professor of Peychistry

Mex

MF/mr

think you might son a chapter on the electrophysiology of
in the revision? It was en omission in the first
drugs
paychosctive
edition which msde tho volune much loss useful {Or an in my teaching.
9.8.

—

Do

you

M.

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October 31 , 1975

Itil,

Turem M.
HZI Research

150 White

Tarrytown,

M. D.

Plains
N. Y.

Road

10591

Dear Turan,
Would you kindln-eend a copy of your report on the
rating scale for TV records in psychophamcological research.
to the chairman of this department, Dr. Stanley F. Yolles. He
is particularly interested in using TV for monitoring sleep,
psychotherapy, and sex therapy. When I described your work to

him, he was unacquainted with

If you have
Many

an

it.

extra, send

me

a reprint also.

thanks.
Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max
I:'

m-

.-

.r

v—p—wwn

«-

:c»

.q'

MF/mr

�</text>
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                    <text>~—:.--w~~ ‘TI,:~V:\-

mu.

7, Iv~-‘mtﬂ-V'KI"7

-

"~«W'r’em .u “w-I'VV-as-VF‘VZ—‘K'e .W‘wmwrum»

'nmm

Jun

‘—~&gt;v

u

mph-v“ we “w
w,

v

~..

_,_, rm...‘

Tun—r mun-he.

.,,

v

‘ "Immvwx

.ﬂ.

‘4

November

Leon

Raisin,

1h, 1975

M.D.

Chairman, Organizing Committee

let International

Symposium on Neurotoxicology

N.Y.8. Psychiatric Institute
722 west 168th Street

new York, N.

I.

10032

Deer Dr. Roizin,

It is

indeed an honor to here your

ipate in the International

Symposium on

invitation to partic-

neurotoxicology.

effects of most paychoective substances
effects that these substances have on brain function, it
is difficult for me, on a scientist who has endeavored to identify the
CNS effects of these compounds because I believe the-effects to be ther—

depend on the

Since the beneficial

apeutic, to invert my findings and View them on "toxicology." Indeed,
to review these findings as neurotoxicologz would be very difficult.

I am reminded of the pharmacologic adage that one man's poison
another men's medicine.
effort

I thank

would be very

you

may be

for the invitation but regret thei such

difficult for

me.

an

Sincerely yours,
wan”

Fink, M.D.
Professor of Psychiatry

Mex
Agar-amen:

«w

MF/mr
wivm‘erWWWmﬂm‘mWﬂ’W'

wa'kn'w‘

WWW

&lt;

�</text>
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1h, 1975

William G. Clark, Ph.D. Chief
Veterans Administration Hospital
Psychopharmacology Research Laboratory
Sepulveda, California 91318
Dear

Bill,

‘nwwwm-IVLAW

The
-

Lecture courses are given in psychopharmacology.to the medical students.
15 1-hour lectures which are given by muself and my

course consists of

co—workers.

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A similar lecture course is given to psychiatric'residents. In each of
three
their
years their exposure varies, so that first—year residents have weekly
seminars and lectures; second~year students have about ten hours; and third—year
students have lectures about special topics such as childhood payehopharmacology,

geriatrics psychopharmacology,

and drugs of abuse.

Psychiatric residents get an extensive experience in clinical psycho—
pharmscology since the leader of our residencyyttaining program is one of my
students who is convinced that hospitalized patients are benefitiddnnst+bvyblbe
logical ﬁlnﬁﬂment, and least by verbal.
Residents may elect to work for six months or longer ql‘an elective in
which
evaluate new drugs the efficacy and safety. ’Two~residents'are in
the units
such
now.
experience

It is

-

.

how to answer your question concerning lab work. The
monitor
their drug treatment by blood studies done at
residents are required to
least weekly,m at least monthly, anE EEG. neuropsychologiosl; and memory tests

not clear

at periodic intervals.

I

V

.

,

in

am glad that you hams a shapter on EEG and drugs
man.1t was a
Beside
omission
can
think of no
in your e-arlier session.
myself,
significant
be presumpand
write
such
woulﬂ
than
a chapter,
one better Qualifiea
Itil to
me
of
tuous
to attempt to modify his text.

V.

_

‘

wags-'1'!

I

it

Sincerelnyonrs,

nynjwwwvm-

Profesaprlof'Pnychiatry

m

mm:

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                    <text>,

-»

,-.

.m—wm-‘r

‘.

w;'

.u

—

.

"n ..- ‘&lt;py-1"'-"

Boveﬁber 1h, 1975

?

v.11.
«new,
Peychiexry
Pro eeeor of

En

'1:

in Residence
Xneﬁituxe
neuropeyoh1e$ric
Langley Porter

University of Celifbrnie
Sen

Deer

Frencilco, California

9h1h3

loch,

time we
from my

for your kind invitation. Ae the
met I had been under name pressure in not having heard
He
son in e number or weeks. I finally reached nine
so
Thank you very much

is planning to came home in: Thanksgiving
the pressure is off me at this time.
I hope to be able to cone Whit early next year end
ueuld be delighted to eccept your invitexion.
seems well end

My

coopereﬁivee

—

beet regard: and

my

notional thanks for being so
Sincerely years.
Me: Pink, M.D.

Professor of Psychiatry

MF/mr

�</text>
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                    <text>ﬂmnv‘:u‘iww,‘

sv-

or
w

aP'D.’_'

[in

wanmhcr 20, 1975

Irving Taylor,

M.D.

Ellicott City,

Maryland

Taylor
Duar

Manor

Hospital

210h3

Irv,

I finally fbund the tin» to read the two volumes edited
by Frgnk Ayd you 30 kindxy sent ma, the one on Rational Plycho—
pharmacotherapy and the second, on the Medical, Moral Issues. I
admit I expected tha usual conference fare —~ overdcne chicken,
peas and mashed potatoes —u but was pleasantly surprised by the
variety and freshness of the subjects as developed by the partici—
pants. The insane of research subjects, right to treatment, and
legal~psychia$ric problems axe well covered, with some refreshing

insights.

I thank you again fbr the thoughtfulnoaa in your gift.
Sincerely yours.
Fink, M.D.
Protbnsor of Psychiatry

Max

MF/mr

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November

Ms,

21, 1975

Jesse Halt!

1521 Sylvia Inna

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York llSSh

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Dear Ms.

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—

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uv—«w—

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um

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hamn

18th.

discontinued our studies of

marijuana and relinquished our pormit lama tins ago.

I

mammww—vmmwvv—wr‘w&lt;mmv'w.-—,m~

do not know anyone

conducting such research

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at this tin».
Regretfully.

,..na——-—r—.—.

Fink, M.D.
Professor of Psychiatry

Max

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Lin

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,

mnwwwx

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Dr. E. Kht: visited us sk tbs and of the summer. When
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ﬂack.

Wb aaruod to rciﬁbnrso his expanses.
thn
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,..Vn.‘...r..‘.._,.,, .-r.u.,..—v.w».

,

w

.V.. r‘

my

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vwa-rwm'v3m'"m .-.~3..,..~,,

\

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FM",

y.

x.

.

.m m. "T&lt;)-,rv-.-~-w-z.~~wv-...a

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w".

~vvwmm-w-Ar“"

4-.

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u w a“ .

W

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1,

Doceﬂber
"'er

1975

Kbnneth Elam. Ph.D.

Editor

‘

q-wmwv

"hm-v;

‘
‘

.2‘

am

nmvrmum:7r

ancrtunnt of Pharmscology
_Tho‘Uh1vuraity of $.23:
Bhalth Science cantor at San Antonio
7703 Floyd Curl Drivu
San Antonio, Than: 7828h
‘

Dear Dr. Baum,
Thank youffbr

the invitation to participate in the

volunc, “Social Meaning of Drugs."
mitmnnin are too

great to «lieu

me

I rogret that my prosent cam~
to give this qnhation preper

attention.
As

an

alternate, you,m:y wish to invite Alfred

,Frecdman. M.D., of tho

New

York Mbdical 0011033.

He 13

K.

unusually

sophisticated in the issuah of tha social and clinical usas of
drugs.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Max

.1 :

._r..

v.“

.7

.

�</text>
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                    <text>December

2,

1975

Dir. Ken 8.101111

Dupartnont of Public Safhty
lhh - Administration Bldg.
SUE! at Show Brook, 3. Y.

Room

In:

ARA

momma,

Md).

Dear Mr. 85011.11,
The above-named

is a

member

of the

Mutant

of

Psychiatry and Behavioral Science and as such should be afforded
a parking

sticker for tha

”Y"

parking

lot.
Sinmmly your: .
Fink, M.D.
Professor of Psychiatry

Max

KF/mr

�</text>
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                    <text>December 2, 1975

Lcthar Kalinowsky,

115 E. 82nd Street
New York City

M.D.

Dear Lothar,

I read, with much interest, your note about the Congress of
Psychiatric Surgery, as published in Psychiatric was, and wondered about
the lack of interest that you cite. I wonder if the political factor you
cite is indeed as strong as suggested. I would look to ourselves, for I
find that our peers, particularly those in the Society of Biological
Psychiatry, are as smug and as disinterested in clinical issues as the
rest or the APA.V Another factor may be the lack of publicity for the
Congress, for I cannot recall seeing an invitation.
One response that may be helpful is for the secretary for the

next Congress to send announcements to the mailing lists of the former
Electroshock Research Association, EPRA, the Society of Biological
Psychiatry, and the American Psychopathological Association.

Another response, if you believe that the Society of Biological
Psychiatry, in swallowing the Electroshock, cog, and Insulin groups, should
be interested, is to act to lead that organisition along clinical lines.
I have been dissatisfied with the programs of SBP, and I discussed this
with Charles Shagass a few years ago when he was on his way up in the
Society. He seemed to listen, (with one ear) in appointing various comp
mittees last year. we did have a clinical group for the Program Committee
this last year. He also appointed a Nominating Committee of Leo Alexander,
A. Friedhoff, and T. Itil. These men, however, under the leadership of
Leo Alexander, elected chemists to the leadership
and with the aged
hands of Wortis, Himwich, Bennett, and Thompson still very much active,
there iaslittle hope for a change in the next row years. Perhaps, in your
position as a statesman of the Iociety, with Heath, Alexander, Nurnberger
as friends, you could still see that young men, with clinical interest,
are appointed to leadershipfroles, especially the Journal and the Program
Committee. Then the society could play a clinical role, as it promised to
——

play when it absorbed the clinical societies, and psychosurgery could get
a reasonable hearing.

�Lather Kalinmky,

M.D.

12/2/75

~2~

could consider the development of another notional organ~
isotion on the somatic therapies elons the lines suggested by Len Commer.
(One

This is a formidable task, and one that would be conflicted at the outset
because of the different constituencies ~~ the academicians. clinicians,
and

the hospital therapist with

little academic interest.)

Another suggestion: would you orier a panel on peyohoourgery
program? It may not be too late.

for the next meeting's

Perhaps some of these actions would serve to alert members or
our organization: to the next meeting of the Congress of Peychiotric
Surgery. At the least, perhaps this note will remind you to add my name
to the mailing list.
My

regards.
Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mex

MF/mr

P.8.

~

Your

it,
and Turkey.

on

letter

but perhaps

on

we

-

I've never been
the Orient Exprees was stimulating
could try e section in one of our trips to Greece

�</text>
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                    <text>N

wr&lt;.q-~&lt;

v,

.rv.”

«WW—m

W

December 9, 1975

:

c.

Jlf

;}

"

~

5

.

A. CObb, 14.1).

Assistant Protesnor
university of California, Davis
Department of neurological Surgery
School of Medicine
hBOl X Stroct
Saorsnonto, California 95817
Dani Dr. Cobb.

..,F

The

material.

is

on exporinontal compound
two clinics in the
(Dr.
S.
Ferris) 1nd at New York
Univorsity
Mbdical College (Dr. R. ﬂornbush). Both are foouasod on single
trials in umbulntaeyy»outpat1onts and are at loust two your:
away from multiple aone triuls.
ACTHszjg

trials in elderly patients in

now in photo 11
U. 8. ~ at How York

I regret thut the ortiole ruined premature hopes.
Thank you

for your inquiry
Binoorcly yours,
Max rink,

M.D.

Jrofbsaor of Psychiatry

�</text>
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                    <text>. -~,~..~.vr.v1\-—..,m“MW

57,...

wv'tnAs-

,;

w

:....---n

m..-

’7.

up t:.w..w;.~.wm—.'Anurw"n

r

wmnmwy,qw.m. hm.

. _,., “w..." »'v--v6‘vr-".'"."

1—5. :‘

,‘V

--

,-

v

'v

-.4~,~

—

7
4

V.”

vamwwu

N

:s

_.:.

wv

Decsmber 11, 1975

~qu

Dr. William Eudspeth
Division of Behswiorsl Sciences
Medical School
University of Hsvsds
Rana, Nsvsds 8950?
Bus: Dr. Budspoth,
Enclosed are two of our latest reprints. Most of the
work can bu found in the summary report.

citations fur our

If s special aspect of this work interests yau, I
will be glad to sun's: s specific inqniry.
For s mare general rcviev of the problsn you may wish
to gut tbs vnlnmn edited by Dr. Itil. tram which this chapter is
abstracted.
Thank you

for year

intsrlst.
Sincsrsly yours,

‘

ur/nr
Enos.

Fink; M.D.
Professor of Psychiatry

Mix

~r—

�</text>
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                    <text>,

w“

‘

V.

,» -.~vr :‘mv.v‘-'WF.~',

w—w—

, .,

mm

,1

,

-. v

\"u 3-

““7

u‘

any. «n—

NV-r-v.‘

.~

uw—v wan—r ww-r—r‘wrwxmw

‘v‘rww—V

“iv—T.

7..

n. kuqu. -vm~“-n

mrmmwuww 5—».qu

"V'rwvruurt-E

MM

December 11. 1975

Dr. Boston Martin

Chief, Spinal Cord Injury Service
East Orange V. A. Hospital
East Orange, N. J. 07019

martin,

Dear Dr.

The work

with

ACTH

h~10

htl

been aeueribed in exccllent
318%, 1975 by Jtan

detail in "scieneo," August 23th and August
I

Mnrx.

in

man.

eonmend

to

these artialca to you.

David da Wied but not publinhed any work on Vasopreasen
my knovladge.
I do not have a file on his animal studies.

feel thn$ there 1: an applicntion for
at the V. A.. it may be useful for you to
know thax I hold the IND for human studies and would be glad to discuss tha project with you.

ACQB

h~10

Should you

in your

work

Sincerely yourn,

Mb:

Fink,

M.D.

Protester of Psyuhistry

MF/nr

�</text>
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              <elementText elementTextId="60792">
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              <elementText elementTextId="60793">
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                    <text>4.:

6%”

“--

n
-&lt;&lt;

.-

December 11, 1975

cw!'\“"mqw

5—:

Secretary,

New

2

Committee on Admissions
York Academy of Medicine

East 103rd Street
City 10029

New York

Gentllunn,
Yolles,

I ea pleeeed to second the nunihntion 0! Stanley P.
a Fellov of the New You! Academy of Medieine.

M.D. en

I have known Dr. Yollee for more than a decade, first
in his role as Director of the Setilnel Inetitute of Rental
Heelth, end since 1972 as Cheirmea of this Department of

Psychiatry.

He is an outstanding physician. edm1nietre$0r, end e
hnneniet. I believe we would‘ve hencred to count binmuons
cur Fellows end I em pleased ta reoamnend his edniueipn. gj.

Sinceruly ydufq, ;?N?~vﬁ=

.ppi
ychietry

Fink, M.
Professor of

Mex

w;
i
I

!

MF/mr

‘

‘
&lt;A..r—w-~.

«-

.

�</text>
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              <elementText elementTextId="60782">
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                    <text>:

uv—

n

'rv- ~-.-

.-~

.w-

v.

-

-,-,. “ “are...“
-'

*

.._

w

'4

'

.

.. "W w“—
*W'“'

-

w-

'r-v—n—w awn-.w—w-r-w...

Home

-, m.

n

"w

...._..,__...
.

.

-, r

,l

bro-rm,»

w.

.n,wm-mmwur-m “.4 l.

.nm

33W

.—~..

veg—um".

—-~—w——W—r

Decembeerl2, 1975

Richard I.H. weng, M.D., Ph.D.

Professor of Clinical Pharmacology
Chief, Drug Treatment Center
Veterans Administration Center
5000 West Notional Avenue
Wood

(Milwaukee), Wisconsin 53193

Dear Dr. Wing,

In the ebsence of Dr. Swanson.

South Africa,

who has

returned to

I shall try to respond to your letter to

To the best of my
LAAM-Methedone project were

Dr. Ling.

recollection, the participants in the

considered co~inveetigetore. Surely,
Dr. Swanson and I would not have volunteered our participation
bed this not been assumed in the negotiations.

your letter.
I am surprised by the posture reflected in
error, and that your
I trust that your View of the matter in inwish.
letter will achieve the clarification you
I trust the matter will be resolved amicably. With best

wishes for a happy holiday season.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

MF/mr

cc/Welter Ling

.

,

�</text>
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warm-u-

,

’Iﬂ‘l‘er'ﬁlnyi:u

a

.

‘7

-__.... ..., “my ,,
,

”nu” , in

»,—.W,W.—mw. 7.--.

December 12, 1975

Jchn R. Bergen. Ph.D.
wcrceoter Foundation for
Exporimsntal Biolcgy
shravcbury. Hasuachunctts Olshs

Thc

Dcar John,

I am pleased to nominate Dr. George Heninger fur
aaibcrnhip in the Society for Biological Psychiatry. I have
known of his work for more than ten years and have followed
his cloctrophyniologic atudicn with intcrcst. He is a capable
investigator and has contributed much to our understanding of
tho electrophysiclcgy of psychoactive drugs.
His curriculum vitae

I

command him

is attached.

for maubcrship.
Sincerely yours,
Fink, M.D.
Frofeasor of Psychiatry
Max

MF/mr

Enc.

»

.v .

7“.er—

�</text>
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»

\
...

m

"TV—w.

'_,._..,_,,...

.A

—
-

_~.—4»

-n—l

VF'J'vng‘

Doccmber

12, 1975

George R. Honinsor. M.D.

Associste Professor of Psychiatry
School or Medicine
Department of Psychiatry

Isle University
3h Park

Row

Street

Haven, Connecticut 06519

Dear George,

I receivsd your letter or December 9 and sympathise with
the expressions. I on plcssod to rocommond you for membership in
the Society of Biological Psychiatry and will vrito a letter of reference on your behalf. You msy wish to ask C. Shagsss or T. Itil

to second the nomination.

Membership in the ACE? is more complicated. Esothellow
one nomination s your, and I have planned to nominate one
of my studonts for 1976. The nominations for 1975 are slrosdy

is sllovod

closed.

or the societies that are active, the APPA seems most
responsive and perhaps your attendance at the next meeting would
permit you to Join in the discussion of the issuos which you raise.
The Society of Biological Psychiatry is not very active in such issues.
although thore was some interact in the California regulations of
EST and leuootomy at the lsst wasting. Perhaps there will be some
activity this your in San Francisco. Abstracts are requested by
January 15 for that wasting, and should be sent to Dr. Iver Small

in Indianapolis.

The last question is difficult for no. I have no inkling of the program for the 20~yosr rovisw of the ACKP.; You may
offer your suggestion to Jerome Lavina, Burt Schiclc, Philip May,
or Al Diﬂsscio, who usually scum knovlsdgesbls about ACNP matters.

Sincerely yours,

as: Fink,

M.D.

Professor of Psychiatry

MF/mr

�</text>
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mvr—w-.- Vﬂru— W.ﬂ‘mmm—w~wai'»i'wcvn—'wwu—:.—...w_..a-,. ...,.

w

,

__.

,

.

vi

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.

.7

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i
December 29, 1975
Mr. Gavin Borden,

President

Garland Publishing, Inc.

ShS
New

Madison Avenue
York 10022

Dear Mr. Borden,

your

letter

I recall the flight from Houston with pleasure, and
stimulated me to retrace the conversation.

It is

simple for me to send the enclosed report, which
was put together by one of my students in June, 1969. We have since
used it as a text for resident physicians at our training center, and
.

1'7W"-&lt;1‘.

Wm'm'wmﬂ'mm-wwﬁw

on various occasions, I have distributed copies to students at other
schools, usually when I have been asked to lecture on the convulsive
is clear that some sections
therapies. In reading the volume today,
should be updated, the references augmented, but on the whole the
descriptions remain quite accurate and useful.

it

difficult, however, is to estimate the market.
experiences with the publication of a conference proceedings,
I am of the opinion that advertising is more important to the sale of
a volume than the content. An estimate of the utility of the volume
and its sales would depend more on the advertising than on the details
or their accuracy (although I could assure the reader that the text
is as accurate as possible).

Following

More

my

Should it seem feasible, the text could be updated and
revised within a few months. Perhaps you would read this text, and
if there is some interest, we could meet on one of my next trips to the

city.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_

_,

,

,_

�</text>
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                    <text>”:4

,t'vrwﬁu,""

v-

January 9. 1975
Dr. Khlkerni

Associate Director, Peychophermecolosy
Abbott Leboretories
Earth Chicago. Illinois
Dear Dr. Knlkerni,

Professor

suggested that I send you the enclosed
Itil
some of the date from our
which

represent
papers on Thoudelteu9,
studies or the cannabis derivatives.
studies in
initial
EEG

Kev York, we were interested
end
defining the significance
effects
in characterizing the
merihunne
and heshish.
THC—deltep9
of
in the response of

In our

we confirmed

these observations in occasional users

by similar studies in long term chronic hashish nears who had
clear evidence of tolerance.

we been been street by the
THC~delta~9, when looked at

In defining these patterns,

profile for
significance or the
from the vantage point of the hypotheses relating
behavioral response or drugs in men.
EEG

EEG

effects to

I truet these papers are useful.
Sincerely yours.

% ,1 4;, Amu“
a

Fiﬁ,
m
Professor of PSyehietry
,

MUD.

cc: T.

Itil

�</text>
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                    <text>0%
January 13. 1975
William E. Crisp, M.D., Chairman
Department of Obstetrics &amp; Gynecology
Maricope County General Hospital
2601 East Roosevelt,
85008

Phoenix, Arizona
Dear Dr. Crisp:

Your letter of January 3 raised a number of
questions, the answers to which are unclear. I couldinteresting
not
these from my own experience, and referred to the volume byanswer
Kalinowshy and Hippius (see page 198), and discussed these with
Lothar Kalinowsky, Richard Abrams, and Dr. Edward Sachar of the
Albert

Einstein College or Medicine.
The observation you

cite, that

hypothalamic stimulation

ovulation is true if the locus in the brain and the
electrical parameters are well defined. In EDT, seizures are
generalized, currents are large and many areas of the brain may he
affected—~1ndeed the effects may vary with the location of the
electrodes and the configuration of the skull so that effects
may
be more variable than in depth electrode studies.
may induce

we are not aware of an increased
rate of pregnancies after
Since patients who are severely depressed often complain of
interrupted menses, their appearance after successfuly treatment
is usually interpreted as a facet of their improvement.
Whether
the return of menses and the likelihood of pregnancy may follow
has not been studied.
ECT.

In menopausal women who become depressed, there may be
interruption of the menses, as with younger women. Following
treatment, these women occasionally menstruete again and it is
difficult to say whether their menses have returned after meno‘
pause or whether the depression inhibited their menses and the
lifting of the depression resulted in a continuation of the menses
an

until a later
inquiry.

menopause.

I trust these answers are of

some

use.

Thank you

for the

Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

�</text>
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                    <text>an.—

A
A

“WK

V,”

1W,.,,._,,m,

.

,

,.

e

_ -FV Ham's—n t.

.

.

_,..

v

7..

"A: w..~~ﬁv-u~-,.t
-,

,

_

va

m

..
‘7»

‘7“

.w....u.w... . ,

.,—n.

-a" . 1.4"»

wry—,1!

wr-

V‘

w

.7,”.

Hemp. nr4w

‘

&lt;~

January 22, 1975
Mr. Robert L. Robinson,

Psychiatric

1700 18th

News

Street,

Editor

N. V.

weshington. D. C. 20009
Dear Robbie:

is often fun, and some newsworthy
mixed in among the edvertisenents. In the latest issue,
found some book revieve of interest. particularly the one on clonoReading the Psychiatric news

articles get
I

It is a poor volume, and I use surprised that your editorel
committee chose that eolume end have ignored the volume, ”Psychobiology of Convulsive Therapy", edited by myself, Kety, HoGeugh and
Williams, 197h, V. E. Winston and Sons. The volume was sent to the
APA for review, and has been ignored. Until I sew
your note on clonetherapy, I thought it wee a reflection of the APA's preeminent interest
in soft-heeded psychiatry. Perhaps it's a matter of squashing wheels
end grease
anyway. thought I'd squeak a bit.
therapy.

—

Regards.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Hex

erd

my" ,.r.,n._..“.. .,

e

__.,‘V,‘..,...‘.,,

/

“thew...”

�</text>
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.77..—

.ﬂ

...=

,, _,_

—_r.~_a.-r"~_.nv ,.

7.,

_

"—1.? “v.

w

'1‘ “H W.

.

.7 ”amuucv—n‘ ,Shnwi_ iv .WV .7

\

,c

January 22. 1975_
Steven Schloasberg,

Janssen

R

&amp;

501 George

New

D,

Inc.

Street

Brunswick,

New

M. D.

Jersey

08903

Dear Stgve:

.vn

(«hi—v.7"

.Congratulations on your new position. From my know—
ledge of Paul Janssen and his teams, you will be kept busy with
interesting and novel ideas. My Bast contact with Janssen R a
was with regurd to tho central effects of an anti—helminthic
with presumed antidepressant qualities - tetramasole(?). What
did happen to it?
My

1..

best regards.

an"

Sincerely yours,

7*

.7.

lmuu"!-«1::~.'V".‘~xr

Fink, M. D.
Professor of Psychiutry

Max
-

maﬁa-"1:

..

v.»

”an-mum.

vwmrwvww‘

A

Merd

D

�</text>
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                    <text>‘.
6w:

:nuprnq-a'v.».a

—vs

January 2h. 1975
Frank

J.

Ayd,

International

Jr.,

M.D.

Drug Therapy Hewsletter
912 west Lake Avenue
Baltimore, Maryland 21210
Dear Frank,
»

Thank you

for your

letter

concerning your candidacy for

the APA. On two grounds, the letter distresses me - that the APA
presidency is politicized, and that someone without "training" in
the Job by prior experience st the APA would consider assuming

scientific society and it is
scientific societies to run political campaigns,
advertising, solicitation for votes, 335, I regret the change
and do not wish to participate in such activities. Nor do I
believe serious scientists ought to participate in the demeaning
displays required of politicians.
leadership.

unusual for

The

APA

used to be a

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

�</text>
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                    <text>February 3. 19$5
Dr. Norman Weiner
Department of Pharmacology

University of Colorado medical Center
Denver, Colorado 80220
Dear Dr. Weiner,
'

is

I

,

2'

writingnon behalf of Miss Carolyn Poinier,
applying for a graduate award in pharmacology.
am

She was

/

first recommended to

me

who

by a fellow graduate

student, with interests in the
2’b1ologioal sciences. who/oould be useful in my study program. I
,6 met and liked her, appointed her as research aeeiatant. She Joined
3*hy staff in the summer # 1973. Our work involves the analysis of
’
the effects of psychoao ive drugs on EEG and behavior in normal
volunteers. She soon begane proficient in EEG recording, interviewing,
data analysis, and in operating our IBM 1800 analytic system. Within
a few months she nanomed responsibility for one of the studies end
2b; Colby College, as an ohtetanding

.

jcarried out with the ninimnn of supervision.
She was bright, resourceful, and dependable.

When

I

moved my leboratory ﬂron New York City to Stony Brook, she elected
to move with no, and}nade the tranhition with relative ease. I

encouraged her to select

field of graduate study and was pleased
that she would like to go on in pharmacology.
I believe eh will doiwell, foriehe is a sincere student, interested
in her work, 2end wh we were able to arouse her interest, we were
rewarded byldedicated\and enthusiastic work. I believe she is
innovativeéand will be hhle to handle a graduate program with caseshould ehe’find a topic t at interests her, I believe her work can
to exceptional. I acumen her highly and would be pleased to consider
when she announced

,her again for

my

-e

staff.

Sincerely yours,

5%

‘

2

,K

j

“.11..

.4\

;

Fink, M.D.
.Profesaor of Psychiatry
Max

�</text>
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                    <text>February 6, 1975

Gordon Merjerrison,

M.

D.

Department of Psychiatry
University of Sesketchevan
Saskatoon, Saskatchewan,
Canada SYN,

(1/

0WD

‘

Deer Gordon:
1.,

drug literature,
trying to catch up on the
an interested in some of your recent articles. In the study of diezepem
and trenxene (Stat. Pbychiat. Z; 31, 1973) your note (page 35): "...there
was e definite drug effect on the left-sided EEG amplitude measure for
each drug over time, the side which characteristically yields changes
in the signal measures which relate to psychoactive drug effects.
"Again (page 36) "...the coefficient of variation (left hemisphere

I

measurement)

and

EEG

am

increased..."

Can

I

assume

Including beta spindling?

the changes were not apparent

on

the right side?

Is there any other evidence_or the aide specificity for
Any other citations I can read?

drug effects?

another mattere I am interested in your EEG studies
with drugs: may I request reprints of your studies of pimozide
(canad. Psych. Ass. J. lg; h37. 1971), Chlorprothixene (Canad.Pbych.
Aae.J. 1g: 533. 1971) and whether that may be in press.
On

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

.'

,
A”,

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                    <text>/

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

€-

Health Sciences Center - School of Medicine
'
De p :1 r‘ment
of Psychiatry
t
and
Behavioral Science

Mr. Gerald

Stony Brook, N. Y. 11794
Phone: 516-444-2413

February 6, 1975

\

Piel, Editor

Scientific American, Inc.
hlS Madison Avenue
New

York, New York

Dear Mr.

U

I

’lfz/I’,,..———e'v“

w

10017

Piel,

two topics for your consideration
-—
American
the effects of seizures (con—
for reports in Scientific
vulsive therapy) on mood and behavior in man, and developments of

I should like to suggest

quantitative electroencephalography in the study of psychoactive drugs.
These topics are quite singular but there are peripheral relationships'
educa—

which makes their review complementary.
tional and social reasons.

Both are timely for

is based on the observa—
tion that repeated seizures at daily intervals elicits long—term’effects
on mood, thought processess and affects in man. It is effective in
as a treat—
allevi ting severe depression and mania, and was developedcoma
(insulin
Convulsive therapy:

This treatment

de in the 1930's, concurrent with studies of daily
coma) and leucotomy (psychosurgery). Their concurrent development has
led to some confusion that these treatments are equivalent, and the
View
same name, "shock therapy" is erroneously applied to all. Many
few
decades,
their mechanisms of action as the same. During the past and leucotomy
however, insulin coma has been replaced by drug therapy,
(psychosurgery) has found a limited niche in the treatment of a small,

ment

m

well defined group of mentally ill. Repeated seizures, in contrast,
are used more widely, and in comparison with other therapies for de-

pression, exhibit better therapeutic results.
While it is customary to say that we know little of the
.
mode of action of these therapies, the opposite is true. The neuro—
seizures
physiology of the seizure and cerebral sequellae of repeated the
induction,
seizure
the
of
The
parameters
have been defined.
on perform—
effects of different electrode placements, and the effects
known
of the
While
is
less
studied.
been
have
and
memory
ance tests
modern
the
to
much
relevant
is
that
biochemical effects, there is
‘

I

�-2biogenic amine hypotheses, and some unique studies of cholinergic
mechanisms are particularly contributory to our understanding of the
role of neurohumors in brain function. Indeed, it is fair to say that
we know as much about the biochemical aspects of seizures as we do
about antidepressants and sedatives.

basic science point of view, the ECT process contributes
to our understanding of seizures (epilepsy), the role of cerebral hemis—
pheres in behavior and particularly, memory; and such psychologic mechan—
isms as the role of personality in depression and changes in task
performance with changes in brain function.
From a

educational point of view, a presentation of the ECT
data may alleviate misconceptions about 'shock therapy' and provide
independent information to allow the reconsideration of laws restricting
seizure therapies now in force in California and under consideration
elsewhere.
From an

Some of the recent physiologic, biochemical, and psychologic
data were brought together by the NIMH in a conference, published
in mid—1971; entitled, "Psychobiology of Convulsive Therapy", edited by
myself, Seymour Kety, James McGaugh and Thomas Williams (V. H. Winston,

(memory)

Washington, 197h).

‘

z

Quantitative ElectroencephalOgraphy: The measurement
of the electrical activity of the brain has been a subject of interest for
more than four decades. During the past 15 years, the development of
2.

-

sophisticated quantification methods based on digital computer programs
and an understanding of the requirements for contrdued experimentation
has defined applications in psychopharmacology which are of general
academic interest. Psychoactive drugs, hallucinogens, and drugs of
abuse have defined effects on brain function in the alert subject. These
effects are drug specific, that is, each compound has a defined signature
which is used to classify the compound. When new compounds are assayed,
EEG classification provides a prediction of their clinical application
before

human

trials
The

are undertaken.

techniques are sufficently well developed to assess

dose response curves and to measure bioavailability and neurophysiologic
equivalence of compounds. Lately, the EEG methods have been compared

with blood level measurements to study the pharmacokinetics of drugs

affecting the brain.

Quantitative EEG has been used to develop automatic sleep
classification scoring systems. Parallel with these systems, is the de—
velopment of automatic drug classification systems.

�applied to problems outside psychoIn
pharmacology.
our understanding of the ECT process, the methods have
shown that electrode placement and hemispheric localization are contributory
to clinical effects. The methods have been used in studies of drugs of
abuse, particularly in the role of THC-delta-Q in cannabis, and in
examining the realtions between heroin and methadone and their interactions
The methods have been

with narcotic antagonists. Some students have assessed the effects of
hyponsis, zen, and transcendental meditation using these methods with
some success.
.

From an educational point of view, a discussion of quantitative
analysis would be of interest to psychopharmacologists, neurophysio—
logists, psychologists, and drug abuse specialists.
EEG

I commend both topics to your consideration. In part, this
occasioned by discussions with Dr. Alfred M. Freedman of the
New York Medical College, who has been a firm supporter of these programs
for many years. Should it be useful, I can supply the usual literature

letter is

and suggest the names of
Thank you

scientists

who

are active in both research areas.

for your consideration.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max
-

Merd

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                    <text>“
v~w~:,-,

."‘&lt;-'wru‘e'

February 6, 1985

Mr.

MoQuade,

W.

Fortune Magazine

Senior Editor

1271 Avenue of Americas
York, New York

New

Dear Mr. Mchade:

this

The

death by suicide of

Mr. Black

of United Brands earlier

it ill,

week set me to wondering whether he had been depressed;
he had
he had sought treatment; and then, to musing that even
he
would
have received the
was unlikely that
seen a psychiatrist,
treatment most effective for depression ~ convulsive therapy - because
as? the many professional and lay misconceptions of this treatment.
.

if

it

it

Among

reasons for

its.lack of use are misconceptions about mental
name, 'shock therapy' , and the bade press,
devastating article published by the New Ibrksr this

illness, the{fond-we

exemplilied y a
summer.

Perhaps this is the time for Eortune, as a follow—up of
the article on psychiatry. to assess some of the recent data on depression -— its genetic components. relations to alcoholism, modification
by drugs. maintenance therapies, and the role’of’nechanism of action
of convulsive therapies.
'

Should there be a story here, I would be glad to get you
or one of your writers started. It has been a subject of research
interest for me since 1952, and I can provide the relevant literature
and

contacts.

However, there is another story of more direct interest
to the readers of Fortune. particularly those involved with drug
development that could be examined. For two decades, I and others
have quantitatively measured the electrical activity of the brain
the EEG), and used these methods to predict the clinical application
of new drugs in the treatment of the mentally ill. These methods are
based on digital computer analytic methods (we use IBM, others use
DEC equipment).
They have been developed so that specific applications

are

now

being made.

�Most

of the established psychotropic drugs have been

classified into nine major classes, based not on their chemical
structure, but on their EEG effects in man. Using this classification,
putative psychoactive compounds have been examined and for a number,
where their EEG classification clearly fit one of the pigeonholes, a
prediction has been made for their clinical application. These methods
have been successful in defining clinical uses for doxepin, cyclazocine,

mianserin, cyproheptadine, and a number of other numbered compounds.
The technic has also been applied to definﬁki bioavail—
and
neurophysiologic equivalence of different drug formulations ability
issues that are of special importance to the drug regulatory authorities,
and to industrial pharmacologists.

Lately, in applied studies relating blood levels and EEG
have applied pharmacokinetic principles to the EEG measures
measures,
and defined the halfuulife, peak effect and volume distribution of sub—
stances as they afftct the brain ~— another important issue for regu»
latory authorities and industry.
we

to other research
principii of cannabis in naive and chronic
cannabis users; the interaction of opiates and their antagonists; the
study of alcohol antagonists; and to examine brain function in convulsive
therapy and in psychiatric patients who have failed to respond to the
expected treatment where EEG measures provide the basis to specify an
alternate treatment.
topics

~~

These methods have also been-applied

study of the active

Perhaps this issue is of more interest to your readers -—
surely of greater personal interest to me. I would be pleased
to meet to discuss either or both these ideas. Hopefully, the talents
of the writers of Fhrtune could be put to a broader understanding of these
scientific and socially relevant problems.

it is

My

best to your family.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

MF:ed

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                    <text>71.-.,»

m.--

w,

ﬁ—’ﬁrV—W—w-?—V

v~

February 10. 1975

Ms. Carol Tuckerman

Kbbs Associates, Inc.
1133 15th Street. H. w.
washington, D. C. 20005
Dear Ms. Tuckcrman:

-

-

~

-

-—-&lt;

,.

,
;

.-

.
,

.

projects

I

lettsrs

am afraid that your
of December 31, l97h
my work under NIMH 13003, 13358, 19h76 in
to
of NIDA was sent to my former University, and not for«

concerning

relation

until this week. Enclosed are some of the many citations
published during the past six years of these grants. They should
fall into the categories (3). (h), and (T).

warded

..
.~,

”awry“

hmanq

since 1967

may be

In addition,
—

cited

additional

I enclose a

titles

copy of my full citation list
which may be relevant to your mission

and sought, as your

contract

may

suggest.

I trust these are helpful.

,.,_.,

Sincerely yours,

Merd
Enclosures

m

r.

v-

u

u.

run

VB"!

a,

Fink, M. D.
th
Professor of Psychiatry

�</text>
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                  <elementText elementTextId="106974">
                    <text>~‘nuvx

ﬁmpvwvsrpnsw.”w..r.-&lt;w-uw~

«

,...,.. r- ”A.

.. an wan-”M1 1-"...me V'Nw‘m-u

:.

-

arr, 2w; JWN;_ “urn—a

”51%".

mm:

w

was

.«v--."'-Il'“

aura—mam

Februsry 13. 1975
Steven Rossen. Ph.D.
Department of Psychology
.

.

Whip

e

M,“

‘

v.

,._

.

”WM!“

Dear Dr. Roses.

Enclosed are the better reprints describing both human and
animal studies of the peptides ACTH h~1o. The summery paper by Yen Riesen

and Rigter was presented in July, 197h and is the best summary of the
work to date. The supporting studies by Khstin ere enclosed also as

these describe the studies at ESE derivatives uhich have the
amino acid sequence as the ACTH h-lo.

same

“V“

&lt;

,

the date.

I look forward to hearing

‘unm-vwv-"a‘wamsh‘

n—

‘meJ

My

from you

after your

review of

regards.
Sincerexy yours,

Mex

Fink,

M.D.

”WNW

rrwuv

‘

‘

,..t

,

A

7

I

.

,

-

“gm—

�</text>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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                    <text>..

v...

,wr

.

w.

.

_.‘ ..H._.

,___,

‘m—y awn-WV

“w“ Wuv'r "Harv-"Wt"‘X!"X“val1'-‘II)U‘&lt;I ‘wW'P—x"‘w-......,.—.._..A .4- mm.

,.

“7....

”-7

February 21, 1975

Thomas Ban, M. D.

Division of Psychopharmacology
McGill

University,

Room

131

Research &amp; Training Building
1033— Pine What

Montreal, Québec
Chnada

Dear Tom:

.

Wm

1m,

.

Thank you for the copy of "Depression and the Tricyclic
Antidepressants" which you so kindly sent me. It is a good summary
of the uniqno views of the Canadian~8wiss schools of psychiatry,
and I commend you on a clear presentation.

Sincerely yours,

ﬁ.—w&lt;~»mr

awry—”NVV‘VMVN.

Fink, M. D.
Professor of Psychiatry

Max
,
,,.
_
A

r”

A...“

v

;
~y.....u.

'v-

”AWWMw.-..x..

mm.

'nvrvl-w‘n

q~,-w-.m~mu«=,

.v

,
v...

..
am

urn-mm;

urn—m:

wax-w

t'rv‘v'v‘

MF:ed

�</text>
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                    <text>Bebruary 21, 1975

Dr. B. K. Shah

Research Facility
Rockland State Hospital
Orangeburg, N. Y. 10962
Dear Dr. Shah:

I thank

there is
of data. I am

know,

you for the many reprints you have sent us. As you
no end of models, and yet, there seams to be a dearth
most interested in the application of these models to

the evaluation of the time course of a drug’s activity in the brain.
In exchange for your kindness, I enclose a reprint of one of our early

studies.

mnny

thanks.
Sincerely yours,

._

w

WWW-

v

“Y

WWW-w..-WVW‘rwr”-FWIWW'FHWW

Fink. M. D.
Professor of Psychiatry

Max

,v-w~..,.,.

MF:ed

Enclosure

�</text>
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                    <text>February 21. 1975

Secretary

Committoe on Admission
The New York Aoadomy of modicine
2 East 103rd Street
Row York, New York
10029
-

‘

Dear

sir:

have known'Prof. Torah Itil since 1958 ~ first as a fellov
scientist; than from 1963~1966 an an nauooiutem at the Missouri Instituto
of Psychiatry; anﬁ since 1966 as a friond and colldborator. I am.vr1t1ng
to ruconmnnd him for modbcrshtp in the Acadamy.

I

1: an outsttnding neurophyuiologint, who has made significant
contribuxions to the quantification of EEG and its application to classia
fioaﬁion of paychonctivn'drugs. ﬁe has keen clinical Judgment and is
internationally known for his evaluation: of new psychoactive substunceu.
Eu

patients.

Ho 13

I

a fins teacher and 1: wall liked by his coavorkorn and

eammond him

reservation.

to your consideration for tollovnhip. without
,

‘

Sincerely yours,
D.
Fink,
m
Profhssor of Payehiusry
M-

MF:od

,

�</text>
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                    <text>February 21, 1975

Dr. F. G. Hermann.
Columbia University College
Physicians and Surgeons
'DO West 168th Street
New York, New York
10032

of

Dear Dr. Hotlinn:
.

for sending me e
It is well written

Thank you

Alcohol Abuse".

copy of "A Handbook on Drug and
and reeds easily.

Since the time when we chatted about the narcotic antagonists,
been some progress - notably, much testing of neltrexone has
has
there
shown this drug to be superior in efficicy and toxicity to cyclezoeine.
Chen next you issue reprintings, it would be helpful to bring this
section up to date, as the work is active.
Again,

my

thanks.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Hex
MF:ed

�</text>
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                    <text>cruv7-(w“wgwuv—‘IWVVWV‘VL""‘V~WWW;'q-mv—wvv&gt;r.)wﬂ~snwv|wlw
m

A».-

,
i
v . v m.“4. WWW”.
1.4:. w m -7...
.. ”“7
w~,.~.qv._mnwr.:.m
rw
-

-

v

.

.‘

‘ww..-

1n:

*ﬂ‘)‘

my.

‘

_r7"

February 2h, 1975
Buoy Jane King, M. D.
Virginia Commonwealth

university

Medical College of Virginia

MCV

Station
Virginia

Richmond

23298

Dear Luyy:
Thank you

for your kind remarks.

unilateral electrodes,

Pa. , 191mb)

with one of

When we

needed

obtained them from Medctnft (Skippack,
and in 1969, they were catdog No. 1031 and cost $18.00.
we

interested in a working document that I edited
co~workers at that time for our residents. Although
dated (June 1969) I think it is satisfactory for your

You may be
my

it is slightly
library.

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Mrzed

Enol.

�</text>
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                    <text>February

2!,

1975

Mr. Bruce Richmen

Baylor College of Medicine

Texas Medical Center
Koueton, Texas 77025
Dear Bruce:

Thank you for the copy of "Drug Issues in Geropsychietry." The
volume, like the earlier one, shows how little we know of the special
problems of drug use in the elderly. It's a good volume (although I
found the typeface a bit smell), which I will-support as reading to my

residents.

Encloaed are some preprints of our recent work.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

Enclosures

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                    <text>Wm WT...- ﬁr “WV—mm-

nv-vw'

.»wwm"ww.ﬂw

March 10, 1975
Ms. Maya

Pines

Washington, D.C. 20008
Dear Ms. Bines,

is a report written last
status of the research efforts in the peptides.
Enclosed

May

on the

Since then, some Of the reports have been published;
the studies in convulsive therapy have had some preliminary results;
and studies in the elderly and mentally retarded have been designed,
funded, and are in progress.
WW.“

N__

n"...

The

latest findings are those reported

by David DeWied

effects of vasopressin; the studies of Kastin supporting
central effects for ACTH h—lO; the reports by Itil that THE, another
polypeptide has CNS effects; and the animal studies by McGaugh,Gold
on the

CNS

and van Buskirk.

I trust these data are of

some

interest.

Sincerely yours,

~.....

_,.__,......-m

'v‘m‘w"wnrJl-remI-5Wun._.wv

nw-wr

r~
ran

.

-A

..

.
‘9‘“.

WW.

rem“

Professor of Psychiatry

�</text>
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                  <elementText elementTextId="103907">
                    <text>March 13, 1975

Joyce Small, M.D.

Street
Indianapolis, Indiana

1315 West 10
Deer Joyce,

pleased to enclose a copy of the final report of
our study of DH-52h (fenmetasole). we had spent a few months
defining the EEG effects of the substance and were convinced that
we had a good profile. To verify this classification. we suggested
a definitise cross-over study. we suggested this, a step that was
consistent with our original protocol, only to have the monsters

I

am

refuse to supply drug for additional studies. This
prepared, reluctantly, as a final stateeent.

summary was

I have had a chance to read a report by Mendelson on
the lack of alcohol blockade for this compound. I believe that his
study. which was poorly done and was not definitive, may have

tipped the scales against further studies of the drug.
On anapher matter, I have been called by Sol Goldberg
to ask whether I would be willing to act as an ad hoc site visitor
to an application from your laboratory. While I felt that I could
act reasonably impartially, I did indicate to him that we shared some
common

interests,

and

that he should ask your approval before

making

arrangements. I would, as you know, be pleased for an opportunity to
visit with you again.
conplete~~

My

it

best regards. Tell Iver the 33? program is almost
should get off my desk during the next few days.
Sincerely yours,

v4

«-

.g

2“
..-.

v.
1.

T

«www-

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                    <text>vawwr
'3

r .-——-—w.-m.....nwwvwryuﬁx-‘vmj-IV'

-

“nuns "Wu '7. 'mﬂ,*\ww~v-I\Winlnwm

W‘- y-o-‘a‘w-p-“szvnW‘s"! -rL—mm—W‘..w.~,‘ "n”- .m»....,... “v.3.

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w

w." .......

w

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s‘r"'w:~n

~

March 18, 1975

Robert Marc Hodges,

D.

M.

3720 Hampton Road

Pasadena, California

91107

Dear 'Dr. Hodges:
To

the best of

my

knowledge. no formal documents exist

any of its affiliated hospitals regarding
of
use
any treatment. Such decisions are left to

this University or at

at

cri~
for
the
the
teria
attending physician, subject to the reviews by appropriate Coﬁmittees
of the institutions concerned.
For our teaching of biological psychiatry. particularly
indications for and the methods of ECT, we usually cite our own
publication of 1970 (Convulsive Therapy - Methods and Applications),
the 1972 special issue of Seminars in Psychiatry dedicated to
Convulsive Therapy, and the l97h volume, Psychobiology of Convulsive
Therapy, edited by M. Pink. 8. Kety, J. McGaugh and T. Williams,
(Winston. washington. D.

I trust these

6.).

comments are

helpful.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

MF:ed

.

.m

..

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.

,V

w. w

_.

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”4......"

Ex

March 21, 1975

John Stern. Ph.D.
Department of Psychology
weshington University
St. Louis. Missouri
Dear John.
—

mum-v"

Thank you for sending the reprinn on the analysis of eye
movements. It came at e particularly opportune time, for I hsve Just
revieved e report from the Chicago group of Holtmen, Levy. et 31.,

measured eye tracking of schizophrenics as the subjects followed
They used hand measurements for their scoring, and I was
wondering whether there was not sons way of measuring this talk more
who

a pendulum.

rr-nvrw—mwm-wnv-«rq-

precisely.

delighted to see that you had developed a method, and I
ask whether I might see s copy of the Harley report on
to
writing
and
the progress report on the effect of alcohol. (Did
method.
the
alcohol affect the saccadic measures. and if so, at whet dose and
time after ingestion?)
-

w—wzuv

«W-Wwawc-.=:Ww

,

am

I

wee

Many

-

thanks.

uvr-lev-‘ww-

Sincerely yours.

,e

Fink, M. D.
Professor of Psychiatry

Max

.

A.,u.-v

Y

r.

.

.m-

�</text>
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                  <elementText elementTextId="103904">
                    <text>mww

!v

r
0'

-.

rm: vvwr 'r :vw

V.»

mm vwcu

&gt;‘err'wer-vv'" -»u—» uw‘mruv-‘uﬁ .. .v.»......m&lt;.vv.—.»v~.~wvww». -....v.

-,

-—-r..r

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. ,7

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—

f"r~'uu:v."r\’l&gt;

-

,.. vmv 1...“,7-“, ,r ,. 7.7.. rm

Turm Itil, Me
321 Research

150 White Plains Road
Terrytown, new York 1059,
Deer Turen,
Our work in bioeveilebility is described in the enclosed
reports, from 1971, lQTh end our latest. "Relation of EEG to Blood
Levels of Peychoective Drugs". The lest will be yubliehed by Merlin

and Gottechnlk.
_

you

in

A

report to the

two weeke.

APA

is being completed

end

will be sent to

a"

The chapter from Gordon

”mm.

m2.-

is

my

only other recent report.
but it essentially

It also cites the bioeveilebility studies,

replicates the report in your book.
My

wqmwmmrmi

best.
Sincerely yours,

wwwummmanc

wee-“m

5w

[~‘§q?'-W“Jw'l

,‘x'h

«a

Wm

"mural-R"

Fink, M. D.
Professor of Psychiatry

Mex

-

:-

.c.-,,..\,,.... . .

Do

W:

Lin-W

‘

March 2h, 1975

w

'

w-

MF:ed

Enclosure

�</text>
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.

-m.——Wzﬁ'm WWW-MVWww»

”ﬂaw—w-

m-“ m..-.- v.‘mm~._ﬂv

V

- .m.“ . .7 .w. w...........,.,

VFW H- WWW... .7. l”...V.W—.—.

March 29, 1975

Julian

L. Barman, M.D.

Department of Pediatrics

The Chicago Medical School
2020 West Ogden Avenue

Chicago,

Illinois

60612

Dear Dr. Berman,
Thank you for the kind invitation to be considered for
the position of Chairman of the Department of Psychiatry. I regret
that I cannot face relocation again, and cannot apply for this
positéon.

If he is not already on your list, you may wish to
consider Charles Shagass, M.D. of Temple University. He is an outstanding teacher and researcher, a political leader (President of
the American Psychopathological Association and the Society for
Biological Psychiatry). and well liked by his colleagues.
Sincerely yours,
.

n

imw'm

Fink, M.D.
Professor of Psychiatry

Max

w

v

�</text>
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.w-pr‘n.

.

.&lt;-nun-wrm.Wmﬁw—Hrun'1‘33rmvu;a.“

,

wwwrwr‘mywwn-..-..-..,.revenw...vgaw'w’

V‘thwrrm'l-

-.«.

March 31. 1975

J. Goethels, M. D.
Philips-Dupher, BV
Centrele Bibliotheek

A.

P. O. Box 2

weesp
The

Netherlands

Deer Dr. Goethele.

Enclosed is a reprint copy of our report. "Quantitative Analyses
of the Electroencephalogrem by Digital Computer Methods, Publication
No. 66-1, 1966", en requested. The 65-10 requested is no longer

available.

volume,
If possible, we would ask reimbursement for the enclosed
Inc.
IAPR,
h02.5h.035.2§67,
account
to
12
deposited
at
guilders,
Algemene Bunk Hederlend, 78 Vijzelatreet, Amsterdam.
Thank you

for your request.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed

Enclosure

m..-“ -_. qr we...“ m7

-

-

o

m—rw- r'

r-

.

n

�</text>
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            <elementTextContainer>
              <elementText elementTextId="60502">
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                    <text>&lt;

“mm—"v.“ —'1

rm»... WW.NWawn-“mm

.

WW mvw—w w

‘w—,-—¢mu-r.muvﬂ.w
,7

m'

.

..

4x.—

.
.
V.ww— .— ——-———.........._
WIJVV"1_v—s—wv—wv—ww

.

.—

.

.

v.

.

r...

. v—-

_

war l.

w-v—vmmw‘

....—.r-

m

~m-

n-m—n-

,,

.v...

.
—...-

-Merch 31, 1975

A.

J. Goethals.

M. D.

Philips-Dupher, BV
Centrele Bihliotheek
P. O. Box 2

weeep
E

The

Netherlands

Deer Dr. Goethele,

Separately we have sent e reprint copy of our report,
"Quantitative Analyses of the Electroencephalogrem by Digital Computer
Methods, Publication No. 66-1, 1966!, as requested. The 65—10 requested
is no longer available.
-

at

12

Bank

On receipt,we would ask reimbursement for the enclosed volume,
guildere, deposited to account h02.5h.035.2667, IAPE, Inc., Algemene
Nederlend, 78 Vitzelatreet, Amsterdam, if possible..

Thank you

for your request.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

Merd

�</text>
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                    <text>W

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

Stony Brook. N. Y. 11794
Phone: 516-444-2447

Laboratory

April 2,
P. H. Van Oot,

1975

M. D.

University of British Columbia
Department of Psychology
2075 Wesbrook Place
The

Vancouver, B.C.
Canada, V6T

1W5

Dear Dr. Van OOt,

still

It is good to hear that seizures and seizure therapy are
of research interest.

Your finding of increased tonus in successive seizures is
‘consistent with the experience that repeated seizures are followed by a
lowering of the seizure threshold. When current factors are held constant,
successive seizures exhibit prolonged duration. Spinal fluid acetylcholine
levels rise and the characteristics of the seizure change so that the
post—seizure EEG shows longer and longer silent periods. The interseizure
EEG becomes slower in frequency and higher in amplitude, and the duration
of persistent slowing is directly related to number, frequency and intensity of seizures. Thus your observation is a facet of the oft—described
neurophysiological consequences of repeated induced seizures. I trust that
in your report, you present data for varying intensities of currents, and
varying numbers of seizures.
comment on the interaction of alcohol and
note suggests the finding was a surprise. Surely,
effects of seizures and of alcohol should make

It is not possible to

induced seizures.

reference to the

Your

CNS

synergism a possibility. Fortunately, such synergism (if indeed it exists)
is not common in clinical practice. One would hope, should you pursue

this line‘of inquiry, that
quency of

ECS; dose

you would carefully specify number and
of alcohol; and the time factors.

fre—

principal reason for answering is to comment on the tone of
It is a potentially
anthropomorphism in your letter. Rats are not
unfortunate extrapolation to speak of "dangerou interaction" and to
join ECT, alcohol addiction and dependence in as complex, unclear
My

sentence.

HEM.

�P.H. Van Oot,

I

M. D.

April

—2—

O
C-

a

1975

recall citations relevant to the question of
although there are anecdotal reports of ECT used
successfully in opiate and alcohol addicts. I have not examined

alcohol and

cannot

ECT,

this combination directly.

For references you may seek the studies of George Winokur
in alcoholism and depression; and Ferris Pitts in ECT.
I can recommend the volume, ”Psychobiology of Convulsive
.Winston, Washington, 197M) and the January, 1972
”Therapy",
issue of Seminars in Psychiatry as sources of review of the neuroof ECT.
fghysio ogy
(V.

,

Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Ilax

Merd

�</text>
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-'..........U.._..vs

~WVW.

mI-'

,

m

rr—wvw—v-w-w—

‘\

\

April 5: 1975
Mr. David

Gelernter

13h3 Yale Station
New Haven, Uonnecticut

06520

Dear Mr.

Gelernter,

had some

difficulty in deciding what our summer schedule will be.
At this time it is unlikely that we will have a

I have hesitated to answer your

letter as

we

have

project in progress for which your participation would be suitable.
I would recommend that you seek another laboratory in which to
continue your interests during the summer. It will probably be

more rewarding.

Should you be on the campus this spring, come
Thank you

for your interest.
Sincerely yours,

Max

Fink,

M.D.

visit.

�</text>
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                    <text>w w~w~rmm1rf ”WNW
un-sr-

———rv~ ‘-

,

.Z‘r'rwv‘u

April 9. 1975

,v
1—;

~
~

«wgwuw

V

J.

Thomas

UCLA

Ungerleider,

M.

D.

Depertment of Psychiatry
760'Weetvood Plaza
Loe Angelou,

Calif.

-

9002h

Deaerr. Ungerleider.
Contemporary Peychology'
congratulate you on an excellent

I have Just reed your review in

to
evaluation. When I first read his volume, I van shocked by his,
biea and relegated the volume to the polemic: on my shelves.» But,
and appears frequently
unfortunately. he in verbal and voluble.TV.
and
I think he does much‘
radio
in new York on school panels,
harm.‘ Your advice to the render. to-evnluete the vork. is excellent.
of Behae' volume and uieh

-

studies in Greece are finally coming to a conclusion.
report as submitted to NIDA at
I am pleased to enclose a copy of thework
is now being prepared for a
the conclusion of the contract...The
the texts_vill
presentation-—hopefully.
more conventional, aeientific
end of the
the
before
co-euthore
vetioua
meet the approval of the
knowledgeable
number
of
a
summer. I have distributed this report‘to
by HIDA
released
until
direct-attribution
experts on the beeia of no
Our own

or published.

Again,

It

may

my

interest

you no

it is.

thanks for an excellent review.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Mex

MF:ed
ENC.

�</text>
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w,,_—...,__~.

..,

_...,,,,,.,.

aura".-

m

~&lt;forvn1x

—uu-

April 1h, 1975
Dr. Austin H. Kntscher
630 west 168th Street
New York, New York 10032
Dear Dr. Kntscher.

for your invitation to submit e manuscript on the
use of andipsic drugs in the dying patient. I regret that I am so
committed that I cannot take on this assignment.

I thank

you

years ago, at s eeting on narcotic analgesics in
eckitt and Colman, Hull, England,
described studies with a highl potent analgesic; etorphine, which
seemed useful in patients with terminal cancer. You may find reference
to his work in: Kbsterlitz,ﬁ., Collier, H. 0. J. and Villsreel, J. (Eds. ):
Agonist and Antagonist Actions of Narcotic Analgesic Drugs, Loneonx,
Some

Aberdeen, Dr. Gareth Blane of

Macmillan, 1972.
uyr!

mm.

If

contribute

he hesnmninteined
to the symposium.

his interest in the topic,

he may wish

mm

Sincerely yours,

w

mmrcm

‘fx

"‘5.”

Fink, M. D.
Professor of Psychiatry

Max

‘

MF:ed

bcc:

«rm

vzscW-uwmsv-

V

\

Dr. Gareth Blane

to

�</text>
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                    <text>3‘

n1..~svm~.—m

w: w-mvwvm-wu—p.. -« vs. -.-rm.—.\—~‘
7,,

w—NW-W

mm—v—a—

“T's“ mu

n—‘w—wle-‘m‘w-q. .—..

w—

m (Maw ‘-

\a

mvmmmm—q——-‘vW'I-C-nt-wI'I-Lw—r-mvl-

’5\

April 11, 1975
Michael Dykes, M.D.
AMA

535 North Dearborn

Chicago,

Illinois

Street

60610

Dear Dr. Dykes,

I have had an opportunity to review the chapter #30,
"Antidepressants" and am pleased to share the following notes and
comments. These follow the pagination of the text.
The classification of espression is that which has
pg. 1:
been used for many years. however, in the past decade, other
classifiattions have been developed, and these are more directly
useful in the determination of treatment. The terms: Bipolar, unipolar,
and neurotic depression, with the subtypes of involutional,
depression of the elderly, and post—partum seem to have more use
in regard to drug selection. I urge you to review the classifications

of Woodruff and Guze, Spitzer, and Robins to name some U.S. authors
have shown the merit of a revised classification.

who

This classification is particularly useful in allowing
a place for the use of lithium.in the management of depression as
it may appear in bipolar disease. The omission of lithium may
be a significant omission, despite the fact that the use of lithium
in depression is still in research. This is particularly true since
the report includes the use of stimulants and monoamine oxidase
inhibitors—— two treatments

that are clearly

no longer considered

efficacious except under exceptional circumstances.

statement that 'different patients given the
. ." seems strong to me. The finding
of genetic components is a suggestion at best and 'are' could be changed

pg h:

The

same dose are caused by genetic.

to 'may

be'.

The recommendation

that therapy with the antidepressants

should be started with low doses, combined with the later dosage
recommendations in the individual sections on each compound is unfortunate for a number of reasons. For the most part, these compounds
are effective only when given in 'adequate' dosages] When one asks
clinical psychiatrists who use antidepressants actively, dosages are

)r awn

.

�-2for
rarely started slowly, except in the elderly, and mean dosages PDR
The
in
recommended
the
dosages
mg/day.
250-350
imipramine are
are a bureaucratic hhlance arrived at in discourse by lawyers and
administrators, which somehow is repeated in official reports. In
checking the summaries for the use of imipramine by Klein Davis,
&amp;

Hollister,

Cole

&amp;

Davis, and Fink

&amp;

for the higher dosages.

Abrams, the recommendations are

I believe that a major cause of failure in treatment
with antidepressants is inadequate therapy, and unrealistic schedules.
In a similar vein, the suggestion that treatment should
be given for 3 to 6 months and then reduced gradullly is a plea
for a regimen that is not common in my practice. Patients who do
well, will not continue medication beyond the second month. If their
symptoms persist, they will also not continue beyond the third month,
in prescription
particularly since they will request and obtain a change and
effective
raised
rapidly
are
dosages
in
If
change
physician.
or a
2—5 weeks;
be
in
expected
can
treatment
a
levels obtained,
response
then therapy should be
if sustainedandfor h—G weeks thereafter,
the patient seen more regularly in follow—up. As an
terminated
example of a more vigorous approach to therapy, the recommendations
A

from some European centers for the use of intravenous thymoleptics
given by infusion over two to five days show some promise and their

findings are consistent with the experiences cited above.

The concurrent use of MAOI and thymoleptics may be
pg 5:
recommended under certain conditions, notably in treatment failures
to thymoleptics alone and ECT.
The

last sentence regarding deanol is gratuitous.

sentence should read '
demonstrated."

pg 6:

The

.

.

.

as an

antidepressant has not been

The

suggestion that other agents, as the antipsychotic

agents, may be useful as adjuncts to therapy

is partially correct.

There is considerable evidence that antipsychotic agents (thioridazine,
chlorpromazine) have been iused successfully in treating some depressive,
not as adjuncts but as primary therapy. See refernces to work by
Hollister and by myself and Klein in the early 1960's.

It

seems worthwhile to consoder the inclusion of
to
the use of lithium; since this section is a
some reference
grab—bag of assorted recommendations. With regard to the report of
the unsuccessful use of TRH, this seems a bit harsh since the results
some
are not yet in and the studies are still in progress. There seems(TRH)
and
(deaner)
those
included
rejected
unusual selection of drugs
when the evidence for deaner is non-existent, and that for TRH still
under study. I would be more Judicious in suggesting that TRH is
the first of a series of peptides under study and that such investigations
should be followed with interest.

pg 7/8:

�-3pg 12:

Fatalities are rare,

pg 1h:

Regarding the question of the concurrent use of
I have no experience.

too strong

and the tone of the paragraph

is

guanethidine and thymoleptics,

The combined use of thymoleptics and MAOI has been
based
largely on anecdotal and uncontrolled studies. As
interdicyed
you suggest, lately some authors have suggested both regimens may
he used concurrently. If true, then the caveat on this page is too
strong and the paragraph may be rewritten indicating that some
reports ahve been made but these are unsupported and that combined
use may be given Judiciously. (Considering the low rate of response
of depressives to MAOI, I wonder why anyone would want to use the
MAOI alone or in combination, except specialists who have adequate
hospital facilities at their disposal. From a cost/benefit ratio
analysis, the use of MAOI should be limited to occasional use by

pg 10:

qualified specialists.

Dosages of imipramine are from the PDR and are low..
doses
at night are useful; the reports beginning in 1961
Single
show that the experience has been a lengthy one. See comments page 1.

pg 19:

A few
years ago, I had an occasion to review the data
recommendation
of combined drug therapy. The dosages are low
for the
and the data unconvincing. Unless there is some recent data (since 1972)
to Justify the recommendation of a combination, I can recall no data,
including those presented by the manufacturer, that would justify
the recommendation even on a 'may be more useful' basis. The data
for the successful use of the single drugs doxepin in cases wheree
anxiety and depression co-exist is more convincing, and that conviction
is a weak one.

page 29:

answer your specific questions: for MAOI, see
for single daily dosage, see below; and for
guanethidine, see page 1h.
To

comment on page 10;

It is reasonable

stress

daily dosage for the
at night, since
given
thymoleptics, particularly if this dosage is
MAOI,
For
there
is no such
the evidence of the efficacy is clear.
above).
10
(see
evidence to my knowledge
pg
I trust these

to

comments

once

are helpful. I

am

less than

enthusiastic about the chapter since the fermat follows our under—
standing of some years ago; and I do believe that some progress has
occurred, notably in dosages of thymoleptics; diagnoses; use of lithium;
single administration; relation to ECT;'and the downgrading of MAOI,
stimulants which are reflected unclearly in the present document.
Thank you

for the opportunity to raise

some

questions.

Sincerely yours,
Fink, M.D.
Professof of Psychiatry

Max

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                    <text>May

15. 1975

Ms/ Darlene Warfel
C.V. Mbsby Company

11830 Westline Drive

St. Louis, Missouri
Dear Ms. Warfel,

it

While
is not clear whether further endorsements of
Dr. Hamilton's request are at all necessary, I am writing at his
suggestion. His comments regarding the social problems created
in Califbrnia by some advocates for restriction of medical practice
are factual, and we are grateful for any assistance that can be
given in altering the laws recently approved in that State.
Dr. Hamilton has been an

of choice in medical practice.
appreciated.

active advocate of freedom
help you can give him will be

Any

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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May

15. 1975

Siva Sankar, Ph.D.

Children's Psychiatric Center
Bellerose, New York llh26
Queens

Dear Dr. Sankar,

thank you for your kind invitation to join in
the next program of the Eastern Psychiatric Research Association. I
regret that my committments are already too many and I cannot accept
any further engagements for this year.
W

the theme is one of neurophysiology, may I suggest
you invite an abstract from my former associate, Jan Volavka, M.D.
of the New York Medical College, and Turan Itil, M.D., also of the
New York Medical College.
As

My

best wishes for the success of your program.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>May

19. 1975

Richard Markin, Ph.D.

1102 N. Harlem Avenue

River Forest,

Illinois

60305

Dear Dr. Markin,
we have not used the
evoked
changes in the averaged
response as a cerebral index since
1966, and I lack the programs that you request. My work is focussed
changes
on the frequency analysis of the resting, alert EEG as

Thank you

for your inquiry.

it

under the influence of psychoactive substances.

principal laboratory working in the area you
seen interested is that of Dr. E. Roy John at the New York Medical
College and Dr. Sam Sutton at the New York State Psychiatric Institute.
These men are involved in studies of the AEP in cases of MED.
The

.._

.1r

You may silo be interested in following the work of
Charles Shagass of the Eastern Pennsylvania Psychiatric Institute. He
has been a pioneer in the IEP in psychiatric diagnosis and has many
computer programs for such measurnent.

4—

Pedersen on

vish to check the volume by Kellavay and
the computerized EEG analysis as applied to children.

right road.

Good

nu

..

.

‘
.
.'1'

"rm“?

.

«7..

r,"

You may

I trust these suggestions will get
luck.

you

started

down

Sincerely yours,

“an“...r.‘

Fink, M.D.
Professor of Psychiatry

Max

the

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                    <text>1/

June 3, 1975
Dear

Fritz,

I have read the report, "Diagnostic Problems in
Huntinton's Chorea and Tardive Dyskinesia" by Martin Buxton with
interest. It presents an interesting diagnostic problem with
sufficient detail and breadth to be considered for publication.

It is difficult for me to be critical, since I have
not followed the arguments in either condition in detail. I like
the report, but I am concerned that my lack of expeeeence may
allow me to make an error in this recommendation. Perhaps you would
consider having this report reviewed by John Whittier, M.D. (Director
of Research, Creedmoor Psychiatric Center, Queens, N.Y.). He is the
resident specialist in Huntington's Chores, having followed families
for more than 20 years, and the one man who could provide the
opinion that you seek.
If

the report (after

he agrees
some

that the argument is valid, I believe

style editing) should

Thank you

be published.

for the opportunity to read this report.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>.7.

June h, 1975
Lewis Harness, M.D.
Chairman, Search Committee

University of South Florida
Tampa, Florida.

33620

Dear Lew,

After much discussion among my associates and with
family, I regret that I am undble to proceed with our
negotiations for the position of Chairman of Paychintry. I
truly admire the special unturo or the facilities, the staff,
and the many possibilities at the University, but find that
the effort may be too great {Or no at this time.
my

I want to thank
for your consideration.

you

for your

many

kindnesses and

Sincerely yours.
Fink, M.D.
Professor of Psychiatry

Mix

ywm

�May

2h. 1975

Lewis Barness, M.D.

University of South Florida
Tampa,

Florida

33620

Dear Dr. Barness,

that I very

appreciated and enjoyed
opportunities are
your hospitality during my visit to
outstanding and the facilities available are among the best I have
seen at any new center. It seems prudent to discuss the many
facets of the invitation with my family and my associates, and I
shall be in touch with you within the next fortnight.
You must know

USF.

much
The

In the meanwhile, I enclose some of the receipts
basis for reimbursement of expenses.

which may be the

Air fate

Taxi (Home to Airport)
Hotel

Total
Again,

my

$176.

8.50

1h.56

199.06

thanks for your kind attention.

Sincerely yours,

Max

Fink,

M.D.

�w.“

—~..W,rmlwr~~m._w..

.

.-.m—-..

-wvvwmmw.” ..,. “Wm rarwwﬁw--."

Lewis A. Bernese, M.D.
&amp; Chairman

Professor

Department of Pediatrics

Tampa General Hospital
Tampa, Florida 33606

Dear Dr. Barness,

for the invitation to visit Tampa and
I have scheduled the flight, Delta 17? leaving
LaGuardia at 0900 and arriving Tampa at 1132 on Tuesday, May 20.
As I shall be going on to Miami Wednesday afternoon, there should
be enough time to visit the installations of the University and to
meet the faculty.
Thank you

the medical school.

I shall be prepared to present a discussion of
"Studies of Chronic Hashish Use", reflecting on the studies in
which I have been a participant since 1969, both in New York and in
Athens, Greece. I should like to review the clinical, behavioral,
and physiologic effects of cannabis use, both in a community of
chronic users and in experimental subjects.It should give the audience
an opportunity to enquire into the relations between laboratory and

field studies.

It

to read any material describing
its facilities, and its present
and projected programs that may be publicly available. I should be
grateful if your office could share such material with me.
would be

helpful for

the dIIelopment of the medical school,
Again,

my

me

thanks for your invitation.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

_..

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                    <text>June

5a

1975

Gerald L. Klerman, M.D.
Harvard medical School
Boston, Massachusetts 0211b
Dear

I

was

Gem.

I. too,

enjoyed the session on Depression and although
enxious
about the materiel before the session, I was
quite

pleased with the result. l have received many favorable comments
from ley as well as professional friends ebout the ECT presentation.

is the present draft of the report

you requested.
some
the
excuse
so
for
publication,
are still re~writing
paper
of the typographical errors and ambiguities.

we

Enclosed

my

best regards.
Sincerely yours,
Fink, M.D.
Professor of PBychistry

Max

�</text>
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                    <text>6,

w

June 25. 1975
Mrs. Jan Boppe
2957 Kalakana Avenue
Honolulu, Hawaii 96815
Dear Mrs. Boppe,

It was kind of you to write after seeing the film on
depression, to tell me of the tribulations in your family. Unfortunately,
the story that you tell is all too common, and all the sadder since,
as you note, more could be done for many of the mentally ill of
America, were the press, the professions, and particularly the
law willing to exercise restraint and good Judgement. The press is
guilty for expanding on the mysteries of our treatments, and for
equating all biological treatments as shock treatments. The very
language is forbidding. The professions (medical and psychological)
are at fault for not insisting that all treatments that are
useful are equally to be available and to be used, insisting that
some are not 'cleaner' than others. And the law, for daring (as
they usually do) to interfere in the relationships of patient and
physiscian.
The

results are often the tragediy that

all too eloquently.

you recorded

My associates and I continue to study the convulsive
therapy process. I believe we have learned much and are now planning
yet another series of studies to improve the treatment process; and
another conference which may be useful to educate our peers.

Again,

my

thanks for writing and sharing your experience.

As a separate thought, should you be interested, there
devastating article about ECT published in the New Yorker
in the summer of lQTh. The article was written by B. Rouche. He
tells the stody of one patient who received ECT inappropriately
and complains persistingly about memory loss. His biased article has
been qudted by many patients who wished not to have ECT. Should you
get the article, you may wish to write to him and express your story.

was a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Executive Director

Max

�</text>
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                    <text>October 3, 197h

Sylvie Levin,
Th Round

Hill

R. N.

Road

Roslyn Heights,

N. Y.

11577

'

Dear Ms. Levin:

I have not worked with nicotine, nor do I have suitable
references in my library. There has been a volume on nicotine
published in a series by V. H‘ Winston and Sons during the past
year.
The only scientist that I know that has been working
Dr. Murray Jarvik, who is at the V. A. Hospital in
Brentwood, California. You may wish to write to him regarding
the evidence for dependence on nicotine.

actively is

Most useful may be a letter to the NIMH Information
Service at 5600 Fishers Lane, Rockville, Maryland. They have
materials which would probably be the starting point in depend—

ence on nicotine.

It is interesting that you have raised a question which has
not been studied in my Lab, and I regret that I have no personal
experience with the problem.
'

"rm—m,

w

Sincerely yours,

w"

‘1Iﬁm.\rﬂ'7‘

,..._.,

any,"

“ml

t

.w'

Fink, M. D.
Professor of Psychiatry

max

“rm-WW7,

Mmzed

'

�</text>
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                    <text>October 8, 1973

Peter Siegler,

K.D.

Htrrell—Nn$1onal Ldboratories
PO

Box 8203

Philadelphia, Pa.
Dear Dr.

19131

Siegler,

Octdber 3, I subaitted a revised page 8 of
our protocol. dated 6.26—7h. That revision was incorrect and I am
enclosing a praper revised capy at page 8. Please destroy tbs one of
last week and substitute the enclosed page.

In

my

Many

letter of

thanks. Our work is proceeding wall.
Sincerely yours,

Fink, K‘D.
Professor of PSychiatry

Max

�</text>
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                  <elementText elementTextId="103896">
                    <text>September 13,

E. A.

Reinstein,

M;

197%

D.

Profeaaor of Neurology
Mt. Sinai Hospital

100th Street and Fifth Avenue
ﬂew York, N. Y.

10029

Dear Ed:

Enclosed are 25 copies each of two reports which may be
distributed to the students in the seminar, "Disorders of
Language and Cansciousneas”. I plan to discuss these as back—
ground fbr problems of the effects of drugs and ECT on brain
function as used for therapeutic purposes.
Again, my thanks fbr your invitation. I understand
to be at the Rumpus Room on 98th Street and Fifth
Avenue, at 2:00 P.M., October 31.

that I

am

My

best regards.
Sincerely yours,
x Fink, M. D.
Professor of Psychiatry

B

Merd
Enc.

�May

28,

1971;

“1'4

—

u
vr‘
u

{rmmgqr

Edwin A.

Whinstein,

M.

1212 Fifth Avenue
New York, N. Y. 10029

D.

.

Dear Ed:

I

would be pleased to discuss my experiences with Em,
psychoactive drugs, and language on either October 31 or Novem1971:, at Mt. Sinai. I an, at present, free both days and
ber

l,

leave the scheduling to your Judmnt.

Sincerely yours ,
Fink, M. D.
Professor of Psychiatry

Max

liked

�</text>
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                    <text>Miwq

October 25, 197“

william Martin, M.D., Director
KIMH Addiction Research Center
P. 0. Box 12390
Lexington, Kentucky

’

Deer

Bill

h0511

Richard Reenick, M, D.
New York Medical College
Department of Psychiatry
5 East 102nd Street
New York, N. Y. 10029

and Dick:

The enclosed

letter

from Raphael Nechoulam speaks

for

itself.

do indeed have a smell supply of A'—THC-DMH.
I will be glad to
make
available to either of you should you wish to undertake a

I

drug

it

test.

Sincerely yours,

Fink, M. D.
Professor of Psychiatry

Mex

Merd

Enclosure

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                    <text>October 25. 197k
John Stern, Ph.d.
Department of Psychology
Washington University

St. Louis.

Mo.

3w-

Dear John:

for lunch. On Thursday I was able to
visit
Ierjenorry to see how quiet and how
empty the laboratories were. The few girls who are left are quite
depressed and it is a tragedy that the leadership was unable to keep
this fine Institution going.
Thank you very much
the institute and was

I learned one fact,which should have been brought to the
attention of the public in 1962. When the Institute opened, there
were more than 2500 patients at the St. Louis State Hospital. The
Chief Nurse tells me now that their census is down to less than 500
patients, and that to fill the empty halls, they have moved aged
and mentally defective patients into the Institution. Sheltif the
public should have been told that much of that reduction, which far
exceeds the reductions in New York State with which I am now acquainted,
was the response to greater care more physicians, etc.
I was puzzled as to where I got my erroneous dates for SPR.
Please note the enclosed which led me to mark my calendar. I also
am sending you the only other communication I received which makes
no mention of a change of date.
My

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry

Max

Merd

Enclosure

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                    <text>'

E. H. Uhlenhuth,

M.

1,

November

1975

D.

University of Chicego
Department of Psychiatry
950 East 59th Street

The

Chicago,

Illinois

i

a

I

60637

Deer Uhlie:

E

§

’

‘

E

.
_

enclosing e few of‘our more recent reprints of
the effects of enti-enxiety agents on the EEG.

I

E

,

em

‘

to these reprints. you may wish to obtain
some of the papers'vritten by Itil. who hes eeserted‘thet the
anti-anxiety agents have e specific EEO profile.
In addition

I trust these ere helpful.
Sincerely yours.
Fink, M._B.
Professor of Psychiatry

Mex

MF:ed

Enclosures

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                    <text>Havcubar 1, 197h

Tektronix
P. 0. Box 500

-

Beavnrton. Oregon 97005

Gontlamon:
.

I would appreciate a aopy of your 197k catalog for
liberatory equipment for tha use of my Laboratory.
Thank you.

Sincerely Yours;
Fink, M. D.
Professor of Psychiatry

Mb:
MF:od

�</text>
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                    <text>November 8, l97h

Elliott Richelson,

M.D.

Johns Hopkins University School of Medicine

Baltimore, Maryland

Dear Dr. Richelson,

For a number of years I have been studying the
effects of standard and novel psychoactive compounds. In answer to your inquiry, I have examined the compounds under study
CNS

find that

classification of 'antipsychotic'have not assessed a new antipsychotic since our studies
indeed,
of butaperazine, thiothixene, and trifluperidol-— and none of these
would fit the sense of a 'new neuroleptic'. I regret this fact, and
thank you for your inquiry.
and

we

none would earn the

My

best regards to Professor Elkes.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

mf/

�</text>
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                    <text>November 20, 197h

E. N. Terry,

M.

D.

Medical Director
Pharme Research (Canada) Ltd.
250 Hymns Boulevard

Points Claire, P.Q., Canada
Dear

Stitch,
I was pleased to review the data for the

compound

Si 93.

The volume consisted of three parts: pharmacology and toxicology,
dated 19 August 1970; clinical pilot studies dated November 2, 1972;
and psychometric studies dated June 17. l97h.
:m—

wmw-ww

The pharmacologic evidence indicates that Si 93 is atropine—
like with tachycardia, mydrinsis, and dry mouth as predominant symytons.
It is readily absorbed and at high doses inhibits gastric secretion.
The anticholinergic actibity was also manifest in EEG studies-in
rabbits and cats where 81 93 exhibited atropine-like patterns. The

anticholinergic activity suggested

its

use as a spasmolytic.

In the clinical studies, the dose range is defined. At
there were no effects. At ho mg. anticholinergic and sedation
occurred. At 60 mg, the subjects complained of fatigue and drowsi5 mg,

.

&lt;

ness in addition to the anticholinergic effects. In a crossover
controlled study of 25 ng and 50 mg Si 93, the differences between
the two doses were small with greater changes in pulse rate for the
25 mg dose.

«luv-v

nun-m

nu-~4-uexlrw-mu—wxrﬂ

g
m...

.m—v

v“

mwn.mrv'ﬂil‘ﬂrr”"

,‘I'VIVFIE

—'vr‘4

—v

test data reportﬂ’interesting findings.
Eight volunteers were seen in a double-blind crossoveg;gtndy of
SI 93 Ild25 mg and 50 mg, oxasepen 20 mgI'IE’E'EOnparison substance,
and placebo. The 50 mg dose of Si 93 elicited greater sedation than
20 mg oxasepan. but also an inner "stimulation". irritability, unpleasantness. feelings of warmth, and some clouding of sensorium.
The 25 mg dose of Si 93 vss found to be pleasant and equivalent to
The psychometric

oxssepan.

�,valnlrm...“ VW'K‘:"F .,

)

;

___.-

er.

,

.
y'vsc. .Y.. _new-m.,.. a._ “wees—w'cv a .&gt;.. W2...”,

.Inﬁu-VHW .“m-v.

V

V

mm “4’".'—'
v

—

-

~ V--

~

'3

1-

.
sn-Mr-w

rv-mww

»

4-,“ w -m n.

—

»

e.

LF—IGY‘
,, wan-VB;w-:’atv4‘lr:'t¢:gr:aw{v-a

.

‘

/

4

E. N. Terry, 14.1).

-2-

November 20, 197k

These observations strongly suggest that 81 93 has central
at
activity the doses studied; that the activity is pleasant and
'tranuillisina' at low doses, but unpleasant at high; that there
a relatively narrow therapeutic range, for the 50 mg dose elicits is
'some of the central deliriant effects of the
anticholinergics. There

are

interesting questions about the compound:
Are the central effects similar to oxasepam (and other
benzodiacepines). or like imipramine (ditran, and other thymoleptics)?
some

‘Does 86 93 have a

at lower doses,

diphasic effect—~sedative and pleasant
deliriant at higher doses?

and stimulant and

These questions can be answered by our present methods or
electrophysiologic assay, for a classification study will define the
Atype of central activity in man and yield evidence of its
therapeutic
range; and a dose-ranging study will give data for the stability or the
nature of the central effects.
'

However, the questions that must be answered by management
before these studies are undertaken seem to me to be: Is there a need
for a novel thymoleptic; and it there is, can 81 93 quality for further
study since it may have a narrow therapeutic range?

If

the answer is affirmative and further studies are desired,
to examine this compound. For a dose—finding study,
single doses of 5.10.20, he and 60 mg should be examined. FOr a classi~
fication study, two doses and placebo could be examined in 10-12 sub-~
Jects over a post-drug four hour period with measurement of EEG, alert.
ness, heart rate, blood pressure, mood ratings, symptom ratings, and
critical flicker fusion (CFF). and the observations compared with our
historical standard? diasepam and imipramine.
we

would be pleased

my

thanks {hr the opportunity to review these data in

It

seems

to be an interesting centrally active

originals.{

My

compound.

their

German

.

best regards.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Max

Merd

Again.

“ah-

.7

�</text>
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                  <elementText elementTextId="106957">
                    <text>November 22, l97h

Dear John,

It

was good

cooperate in any
coming

way

Should you

trip
I

to hear

from you, and

that I can.

like to visit

me

in

I shall be delighted to

New

East, I should like to share

my

York during your forth—

schedule;

'

leaving for San Juan on Tuesday, December 10 (AA653
12:30).
Monday, December 9 is quite free except for a
at
mid—afternoon.
the
in
lecture
from JFK

am

I plan to return from San Juan on Saturday, and am free on
December
16, not on the 17, and then from the 18th on
Monday,
time
can set any
you wish.
Before the

December 7.

ACNP,

I shall be away, returning late Saturday
V

I look forward to meeting with you.

My

best regards.

Sincerely yours,
Fink, MDD.
Professor of Psychiatry
Max

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                    <text>V“, m,,.-_.._lV....V.....‘..w-,.-A

‘pmwwp_m_~._~

.

waqw

,.

,

mar

November 29, l97h

Mrs. Eva

J.

LIJ—HMC
New Hyde

Park,

Meyer

Research Grants Manager
New

York

Dear Mrs. Meyer,

I enjoyed the opportunity to review the two proposals
submitted by Dr. Struve. The one on agorophobia and mitten patterns
seems wotthy of support, although I believe the estimate of time
and cost is probably underestimated by at least 50%.
I could not Judge the review proposal since there is
data missing which would assist me in my determination of likelihood
of success and worthiness of support. Should the proposal be
submitted again (if unfunded), I would be willing to review again.

to the suggestion that one reviewer believes the Bumitten
clinical significance, that is the question which Dr.
Struve is attempting to answer. At present, it is probable that
few observers can elicit the B-mitten and that the pattern is
inadequately studied. Precisely for this reason, Dr. Struve should
be encouraged to continue his explorations and if he finds or
comes to understand the significance of the observation, bb teach
not to

As

have

us, so that

we

can apply the data in our

clinical

work.

Sincerely yours,
Fink, H.D.
Professor of Psychiatry
Max

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                    <text>June 6, 197k

Biesen,

Hank van

M.D.

Scientific Devetopnent

H.V. Orianon

Group

Oss, Holland
Dear Henk,

Hurray

I have received and read the protocol from
and believe that he has expanded his

Jarvik,

interest in memory mechanisms to encompass the
peptides. The protocol is apparently a part of a
large application for research support, and I an
sure that making 01—63 available should add to
the information on the central effects of the
peptides. His review of the literature brought out
additional references which I will get.
Enclosed is a set of reprints from my
earlier work on the effects of drugs (chlorpronasine
and inipranine) on various perceptual and attitudinal
tasks. For comparison, I an also including the results
of induced convulsions (ECT) on these tasks; and when
I was deciding on the ones to select, I found one
or two additional references that bear on our mutual

problems.

is sending Hrs. Rosselson, his
laboratory next week. Thinking
of her visit, I recalled some discussions regarding
T. van LierOp—- is there some merit in having his
2
Leo Lange

technician, to

my

visit

It is already

June;

my

staff are thinking

about the summer holidays.;ny daughter Rachel

is

graduating high school at the end of the month and
we face her leaving for the university soon. The
weather has been fine and we have had some good
week-ends in our country home-- not many fish, but
plenty of repair work.
See you next month in 083 and/or Utrecht. My
best regards.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>June 7, 197h

Richard Resnick, M. D.
New York Medical College
Department of Psychiatry
5

East 102nd Street

Rev York, N. Y.

10029

Dear Dick:

Reading reports of the work of Tennsnt on

Darvon—N

brought to my attention that the principal toxic effect of the
compound may be in its seizure inducing propensity. Nowhere did
I find evidence of CNS studios.
Should you wish or be able to assess Darvon-N for its
withdrawal use, examination of the EEG records would provide an
objective (and obvious) answer to the question.
A

n

I

a

who».

«.1

would be glad

WW

My

nu-

a.

to cooperate in such a study.

best regarts.
Sincerely yours,
Fink, M. D.
Professor of Psychiatry
Mex

MF:ed

�</text>
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            <name>Type</name>
            <description>The nature or genre of the resource</description>
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                <text>Text</text>
              </elementText>
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          <element elementId="43">
            <name>Identifier</name>
            <description>An unambiguous reference to the resource within a given context</description>
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              <elementText elementTextId="60236">
                <text>mfp-05-00-027-7-566</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="60237">
                <text>1974 </text>
              </elementText>
            </elementTextContainer>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="60238">
                <text>&lt;a title="Fink, Max, 1923-" href="http://id.loc.gov/authorities/names/n79039548" target="_blank"&gt;Fink, Max, 1923-&lt;/a&gt;</text>
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          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>Correspondence -- Correspondence</text>
              </elementText>
            </elementTextContainer>
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          <element elementId="46">
            <name>Relation</name>
            <description>A related resource</description>
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                <text>The Max Fink Collection</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="41">
            <name>Description</name>
            <description>An account of the resource</description>
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                <text/>
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          </element>
          <element elementId="47">
            <name>Rights</name>
            <description>Information about rights held in and over the resource</description>
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              <elementText elementTextId="60242">
                <text>&lt;a title="IN COPYRIGHT - EDUCATIONAL USE PERMITTED" href="http://rightsstatements.org/vocab/InC-EDU/1.0/" target="_blank"&gt;IN COPYRIGHT - EDUCATIONAL USE PERMITTED&lt;/a&gt;</text>
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          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
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                <text>Special Collections and University Archives, University Libraries. Stony Brook University Libraries (State University of New York).</text>
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          </element>
          <element elementId="44">
            <name>Language</name>
            <description>A language of the resource</description>
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                <text>en-US</text>
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            <name>Format</name>
            <description>The file format, physical medium, or dimensions of the resource</description>
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                <text>application/pdf</text>
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            <name>Publisher</name>
            <description>An entity responsible for making the resource available</description>
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              <elementText elementTextId="93348">
                <text/>
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            <name>Contributor</name>
            <description>An entity responsible for making contributions to the resource</description>
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              <elementText elementTextId="99909">
                <text/>
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      <tag tagId="4">
        <name>Correspondence</name>
      </tag>
    </tagContainer>
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</itemContainer>
