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                    <text>April 18, 1978
Mrs. Susan Simeon
Royal Ottawa Hospital
1145 Carling Avenue
Ottawa. Canada
Dear Susan,

Enclosed is a set of notes regarding BEG recording
in a manner that will permit us to analyze the records from the
tapes. When you have questions, call Peter at 516 nun 2560.

It

would be

helpful for

protocol for the study so that
the recordings.

we

us to get a copy of the
can review the time and frequency of

‘

My

regards.
Sincerely yours,
Max

Fink,

M.D.

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                    <text>rm." .___»Www. -mr"‘ww-—er-~,w“Wm-w“

n1.

April 21. 1978

Stuart Keill,

H.D.

NCMC

East

Meadow, New York

Dear Stu,
APA TAsk

it

Enclosed is a draft copy of a section of the forthcoming
Force report on BCT. It is the more interesting section for

spells out what we know
provides the basis for testing.

me

as

and what

is hypothesized.

The

latter

There are two advantages for setting up an ECT project::
fun
the research and the upgrading of the treatment processes,
doing
of
the

since research will require supervision of the actual treatments,
monitoring of the seizures, etc. At the moment, I have interested
John Lee who is in charge of unit #2 at Northport VA to set up a
predictor study. The protocol will be useful at NCMC as well.

I have aslo interested

Andy Don

at Huntington to look

at the protocol. I believe that we could set up a good program, with
collaboration between the three institutions, if you are willing to

participate. Is there

someone on your

staff who is at all interested

could you arrange for John Lee, were he to make the formal
application, to work at your center on a part~time basis ? (At
no immediate cost, since he is LIRI funded; if and when we get grant
funds, he would be entitled fo some additional support unless you had
someone on your staff who would take over at that time.)

If not,

?

Stan is willing to consider Dr. Dornbush for you, but he
that he is strapped for funds. How the committment can
today
told
be met is unclear to me, but I asked Dr. Dornbush to write to you and
me

do like her credentials, see her, and if you still like her,
confident that she could organize and work through the ECT project
at NCMC (as well as others).

if you
I

am

Those are my present ideas. Call me when next you expect
the
University and visit with me. (Incidentally, my book on
to
at
BCT is almost complete; it should go to the publisher by mid-June. It
will be a definitive study of "Convulsive Therapy- Theory and Practice"
and should be most supportive of any application fromSBB.)
be

My

regards.

Sincerely yours,

w'm

——-

,..._—....n——_

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                    <text>"W“- .

m ~v,—

"—m—w

mr‘vzrw-‘vvwmw‘w

.

November 24, 1976

Francis J. Braceland, M.D.
Editor, American Journal of Psychiatry
1700 Eighteenth Street, N.W.

Washington, D.C.

20009

Ref: Paper

Dear Frank,
Ah, I wish

deletion

was

# 284

as easy as your note suggested

!

But, I have deleted slightly more than two pages; added a five line
reference to an important paper by Avery and Winoken; and removed
citations. I think the paper is improved, and hope your editors

ll

will agree.

I am pleased that you have decided to publish the papers
at the meeting, including Dr. Friedberg' s. I agree that there will
be some protest, but I think that it was important for the Association
to allow its critic to have the floor. After all, we have invited
Tom

Szasz on more than one occasion.
My

best regards.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

�an
us.-

~—.—.yy“v.w

1".-

June 9, 1976

Francis J. Braceland, M.D., Editor
9
or P‘ ohiat
a:i an J
1700 Eighteenth Street, H.W.
'

washington. DaC.

20009

‘

Dear Frank,

Enclosed are two draft copies of the report "Myths of Shock
Therapy! for your consideration for the Journgg. This report was
;
presented at the panel, "Electroconvulaivn Therapy: Current Perspectives",
at the May 1976 wasting of the ABA, and organised by Curl Salsman. You
should have received (or will roceiva) papora fiumthheobhhsr participants.
wn do hope that they will meet your standards, and that they may be
published together as a group of topical papers.
Thank you

for your consideration.

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

M2:

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                    <text>.5,

Christy Wright
Amer. Jour. Psychiatry
Ms.

June 6, 1977

Washington, D.C.
Dear Ms. Wright,

Please excuse the delay in getting this text back to
citation for the Pribram article was hard to get. I
have indicated the correct citations in the margins in a number of
instances and ask that you correct the text in the proper form.

you; but the

title, Myths of 'Shock'
Therapy rather than Electroconvulsive therapy in the title, since
the term 'shock therapy' is one of the myths that I discuss.
I would like to use the improper

Thank you

I believe I have answered
for your help.

all

your other questions.

Sincerely yours,
Max

Finkk M.D.

Professor of Psychiatry

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center. - School of Medicine
o-

I)cpartmént of Psychiatry

Stony Brook, N. Y. 11794
Phone: 516-444-2413

and
Behavioral Science

June 8, 1977

Kirkman Labs

Portland

Oregon 97208
Gentlemen:
Dr. Blachly

EST.

of

it

recently demonstrated

for

a Bite Blok

I would appreciate a description and price

list

and any other aids for EST you may produce.

Sincerely,
Max

Fink,

Professor
MF:fg

M.D.

�</text>
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If 5&amp;2:
is
i‘
C

W’

I

"

STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

4"

School of Medicine

Department of Psychiatry
and
Behavioral Science

Stony Brook, N. Y. 11794
Phone: 516—444-2413

‘

June 8, 1977

Reuben

Reiter, Sc.D.

187 Sylvan Avenue

Leonia,

New

Jersey

07605

Dear Reuben:

I

would

like to obtain descriptions of your

EST

instruments

as available today, and would be grateful for any price

specifications that

you can send.

descriptions of electrodes
Many

list/

In addition, I would appreciate

and other devices

for

EST.

thanks.

Sincerely,

W

Fink,
Professor
Max

MF:fg

/

M.D.

�</text>
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Department of Psychiatry and Behavioral Science

HEALTH" SCIENCES CENTER

State University of New York at Stony Brook
Stony Brook, New York 11794 / (516) 444 2413
——

June 9, 1977

Hittman—Medcraft Incorporated
P. O. Box 5h2
Skippack, PA 19h7h
Gentlemen:

I
as

would

like to obtain descriptions of your

available today,

specifications that

and would be
you can send.

descriptions of electrodes
Many

thanks.

grateful for

EST

any

instruments

price

In addition, I would appreciate

and other devices for EST.

Sincerely,
Fink,
Professor

Max

Mszg

list/

M.D.

�</text>
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                    <text>June 10, 1977

Prof. Dr. Tetsuo Fukuda
Doshisha University
Kyoto, Japan

Dear Prof. Pukuda,

‘Wmmmw—wW—nwWWW—mv

I am honored by your kind invitation to participate
in the symposium on schizophrenic paychoses in Kyoto on September.8.
I regret that I am unable to accept this invitation, as I will be
giving a lecture at the International BEG meetings in Amsterdam
at that time. I also regret that I shall not be able to attend the
World _pngress meetings in Hawaii as it is impractical to be in
Hawaii and Europe at the same time.

It would be an honor to visit with you on some other
occasion. It is my understanding from the literature that my work
in the development of quantiﬂiad EEG in psychopharmacology has
become established in Japan, and I should be pleased to discuss
the relation of brain rhythme to behavior at a later time.
My

best personal regards to you and Professor Mitsuda,
for your kind and thoughtful invitation.

and again, my thanks
we

‘W—W

_

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>W?
Hatem Al~Chalabi, M.D.

June 12, 1977

Suffolﬂ Developmental Center
Box 788

Melville,

New York

Dear Dr. Al—Chalabi,

I have read your proposal, to study the effects of lithium
therapy on aggressive, disruptive and self-mutilating behavior in
patients with mental deficiency (severe). In the main, the intent is
clear, the issues well thought out, the misSion important, and the
safety well within the margins ordinarily set by our community. Indeed,
I can find only two questions of merit.
Selecting dosages of lithium that will yield plasma
mBq/l is a goal that is set in the study. While these levels
may be necessary, I think that the conservative approach within a new
setting is to set a lower level as the goal, one within the therapeutic
range, but surely not associated with side effects, such as 1.0 mBq/l.
If there is no therapeutic efficacy or toxicity at these levels in
3 to 6 subjects, then the higher level can be set for the remainder
of the sample. If you already have experience at these lower levels,
then this conservative step may not be necessary.

levels of 1.5

The second issue is that of consent. The protocol does not
discuss this issue; one that is a problem since the population is made
up of minors with mental deficiency. A consent form should be prepared
for the relatives, describing the goal and methods of the study.

These comments are my own. Should you wish to have hhe advice
of the Research Committee of the Department of Psychiatry and the Long
Island Research Institute, I would suggest you send a revised copy of
the protocol, with your curriculum vitae and the consent form to the
Chairman of the Department, Stanley Yolles, M. D., and he may
refer it
to the appropriate committee.
Good

luck in your study.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>w»

.~

Jine 17,

mm'

1977

Dr. R.A.F. Pronk and A.J.R. Simona
I'm-WWW

TNO

PO
yr

Box 5011

Utrecht, Holland
Dear Drs. Pronk and Simone,

-m‘~:a-:~ernmmw

Thank you

International

'-&gt;

“wavﬂ'n

“W

.

,A,

1-www'1w,

EEG

Appollan Hotel.

for your inquiry. I shall attend the
Congress and have requested reservations at the

I plan to return to the U.S. after the EEG meetings and
should be available the latter half of September in my laboratory.
You should know that my laboratory is 80 miles East of New York
City, about 2 hours by train.

that
that

visit

While I would be delighted to have you visit, I must say
do very little on line study. The samples of EEG traces
you sent me are very sophisticated, and surely you will want

we

to

Reginald Bickford in La Jolla, California who has a similar
system and interest. I know of no other workers involved in such research

in the Metropolitan area.

Sincerely yours,
,
.
A

‘r

v..p|n"r"._vlvm

my.»

-

Fink, M.D.
Professor of Psychiatry

Max

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                    <text>.-IT!1'."‘-'-&lt;;'.n‘un-nvlr-‘~V

.L‘Imu'elAk-‘w-m

~v,r.~.-u«

.~

June 28, 1977
Joseph

Jaffe,

M.D.

State Psychiatric Institute
Street

New

York

New

York City

722 Vest 168

10032

Dear Joe,

I have just finished reading fStroke'. It is a moving and
thought-provoking document. Clay's trauma was an overwhelming burden,
which he bore with the help of his friends. As an emotional experience,
I cannot say that I am glad to have read the book, for it has made me
sad and reminded me of our mortality.
On

an

intellectual level, I

want

to congratulate you both
which are so personal and

for

clear,
the very fine exposition, the descriptions
and the picture of aphasia which I have never seen before. It set me to
recalling the many months I spent in the Bellevue library exploring the
works of Goldstein and Jackson, Critchley and Lashley to recall a few;
works that were indecipherable and impersonal to me then. Your volume seems
so much better, I can see it of help in the residency programs and in
the care of patients and their families who may have the same experience.
am pleased that one of my friends has
volume.
memorable
I congratulate you. Your loyalyy and
created such a
and
I
feel that Clay has indeed been fortunate
friendship shine through
had
have
in one respect, to
you as a co-worker and friend.
On

another level, I

In thinking about the book as a reviewer might, I can find
that I could criticize or question. I thank you for thinking of
little
and
sharing your work with me.
me,
My

best personal regards to

you and Nora, and

Sincerely yours,
Max

Pink,

M.D.

to Clay.

�</text>
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                    <text>129'.

:t'

'a:g.-¢~w_

w:-vm"7rvn~n. uvawv.~wwc~. yum.

‘y'.§tg8'ﬂ,f

.,. ._,,

,

1...,“

.s. .

- W,

July

,.,

.

"W.

...

.

,

,

,-

‘,

. p...

. .,

.,,.,.

w

m...-

-._..

11 . 1977

Jeanne Smith, M.D.
210 East 73 street
Nev York

City 10021

Dear Dr. Smith.

During the past nine years, I have studied the effects of
cannabis in long-term hashish users in Athens. Among the studies
vere detailed EEG examinations of men who used hashish for a mean
period of 25 years. smoking on the average the equivalent of 260 mg
TBC-dajisaleﬂle did not carry out spinal fluid examinations.

Var‘ﬁ.’

W“

v. .r_.r..w——.—.;mi,w~,,,..v

damage

tests.

In these studies, we failed to find evidence of brain
after prolonged use, either in the EEG, echo—EEG, psychological
and neurological examination.

Similar studies sore done in long term users in Jamaica. The
findings are published by Rubin and Comitss, GAEJA in JAMAICA, Mouton
ress, Paris, 1976. Our findings are in press and will appear this

month (Raven Press. New York, HASHIBH.
Stefanie, Dornhush and Fink. Editors).

A STUDY OF LONG—TERM

USE,

it unlikely that the
spinal fluid protein determinationssare related
to two years of marihuana smoking. I would suggest that your son have
a thorough neurological assessment and if the findings ere incon—
clusive, that other causes for the illness be sought in hormonal

abnormal

From

EEG

these experiences, I think

and high

dysfunction.

I trust those

comments

are helpful.
Sincerely yours,
Fink,
Director

Mex

M.D.

,,,.

... any“...

,_

�</text>
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                    <text>/j

4v

/

August 17, 1977

Dear Mark,

I have not had much experience with drugs that inhibit
libido outside the ones described in the third page of the report.
I, too, have had patients with schizophrenia treated with antipsychotic
drugs who complained that they were less interested in going home than
we thought they should be. A discussion showed that impotence was a

factor.
In

my

I have had more experience with sexual stimulating drugs.
work with opiates (also sexual downers and heroin was regularly

associated with impotence), I used the narcotic antagonists cyclazocine
We found that patients on cyclazocine showed increased
libido, aggressiveness to nurses, and even priapism. We were not sure
at first whether it was a direct result of cyclazocine or the blocihde
of the negative effects of heroin. In an experiment in depressed patients,
cyclazocine also stimulated libido, but here, also, we could not be sure
it was a direct resuly of cyclazocine or a result of the relief of
depression. When we tried the effects of nalozdne, the findings were
never clear. These data were reported by Alfred Freedman about 1972—73.
and naloxone.

studies of chronic hashish users in Athens, of #7 long-term
insisted that hashish use improved libido, performance,
and potency. We checked with the wives, and in social worker interviews,
2/3 favored intercourse with their husbands on hashish Again, we could
not be sure it was a direct effect of hashish or the absence of the
users,

In

my

more than 2/3

irritability these

men showed during withdrawal from hashish. The data
: Hashihh— Studies of Long—Term Use, edited
R. Dornbush and M. Fink, Raven Press, New York, 1977.

can be found in the volume

by C.

Stefanie,

I trust these

comments

are helpful.
Sincerely yours,
Max

Fink,

H.D.

�</text>
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                    <text>August 22, 1977
Dear Jon,

letter of August 9
BCT who
interest. If you have such a

with regard to depressed patients
responded to drug therapy seduced
sample, I would agree that the
data should be published. However, one should be sure that the ECT
was given under conditions that meet present standards for ECT therapy.
Were the number of treatments adequate ? What assurance was given that
missed seizures were re—treated ? Was the diagnosis confirmed by an
outside observer or adequate history ? I can recall no recent report
of such an outcome (since the reverse sequence, drugs followed by
Your

who
my

ECT,

failed to respond to

is the

most common).

The second

question is difficult to answer. There is no

to show that ECT makes neurotics worse. The
predictor studies (Mendels, Carney, Hobson) all show that the more
psychotic the patient is, the better the clinical result; the obverse
can be inferred, the more neurotic (higher anxiety, less delusion),
the poorer the clinical result. There is also the problem that many
patients labelled 'neurotic' are labelled so because of an unclear
clinical picture, and they may develop into 'schizophrenic' patients
at a later date. This group also suggests that the less psychotic
or the less like a standard psychotic picture the patient presents,
the poorer the clinical results. As for specific citations, the most
detailed, citing his own work is Kalinowsky writing in Kalinowsky
good study of neurotics

,.,.

“use”

WNW?“

w—,r;.e..,,;,‘_,.,.,.

v

'1

.

’IH“~P"'-V‘

1.

and Hippius , 1972, pp 242-2u4), Pilowsky (Aust NZ J Psych. 288:88-9”),
Prendergast (Med J. Aust. 2:598—600, 1968) and Carney and Sheffield
(Br. J. Psychiat. 125: 91—9”, 197a). These are good for starters,
although I prefer the inferences from the predictor studies. You
may want to start with our own review of predictors (Brit. J. Psychiat.

l22:#57~u62, 1973).

report has been submitted to the Council of
I think it is quite good, and its recommendations are reasonable.
You will enjoy reading a capy. hhich you may be able to get from Mandel
or Fred Frankel (unofficially).
the

APA.

The APA Task Force

My

regards.

Sincerely yours,
Max

Fink,

H.D.

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                    <text>w.
John C. Kramer, H.D.

August 22, 1977

University of California

Irvine, California

Dear John,
NIMH

I will continue to be optimistic that the funding from
will yet come through; but will answer your inquiry in the

meantime.

The book on

the Greek study

was

published in July and

should be available within the next few weeks. In it, as in the
prior Jamaica study, and the one from Costa Rica to follow, there
is little evidence that chronic hashish (ganja) smoking has any long—
term effects. These observations are in direct contrast to the
earlier literature, particularly from India and Egypt; and the more

recent reports from these countries by Souief and Chopra. Their
latest data may be found in the 1976 conference proceedings (New
York Academy of Sciences, vol 282, edited by Dornbush, Freedman and
Fink) where these authors cite large numbers of psychotic cases
which they ascribe to hashish use. Not only do they cite evidence
for psychosis, but criminality (other than possession of hashish)
as well. Chopra does not limit his findings to patients in hospitals
in India: he says that in interviews with drug users (site ?) he
made the observations. Souief worked in prisons, so his population
also is not a hospitalized one.
I would resphrase the question: Considering the differences
in incidence of behavioral abnormality, including psychmsis, reported
from India and Egypt compared to the studies in Jamaica, Greece, and
Costa Rica, could the findings reflect differences in material smoked;
in the observer ratings; in the sample populations selected for study;
or in the standards used for diagnosis ? If one were to start in
India, it would be important to visit Chopra and assess his populations,
his methods of assessment, and the material his subjects smoked first. If
some differences between the studies emerged from these observations,
they can be verified in subsequent studies.

If hospitalized patients are the focus of study, one could
with Frank Knight in Jamaica. In the Same NY Ac Sci volume, he
has a report, mostly anecdotal, but well written that there is a
defined incidence of psychosis due to ganja. In Athens, Miras was
still convinced that this was true, but when a Greek team visited
the major mental hospital, they were unable to verify a cannabis psychosis
syndrome in the patients hospitalized for a long time. Perhaps the same
start

�FTWT‘Q‘WFTJ‘Wﬂw-l‘ew-Iwuww‘mwv-u-s‘h‘m4"
,

Kramer, John

-4“...

,

_._..~\ .My: H ’1'.)

...........

1.,

x

_
.. u. m true
.,. 3!

V." —wvmr_wmmw .W77_~w:_~~r,..-wrn ......-w~...w.(—I WW»,-

August 22, 1977

..............

page

in Athens could be done in Jamaica. There
advantage of language~~ they speak English.

re-assessment

made

.n...»w:v”v~-w-v‘--—\.c..._.e._

2

is the

«Wm—7

..

..
~v-v!

“3...-

sum—”m.“

mm"

for anthropological and sociological studies is
did not answer these questions at all, partly because we
great.
wished to focus on the findings reported by Hires, that most of
his users had brain damage. But the more interesting question
emerged in our study, as in others: why do cannabis users continue
to use the drug ?
The need

We

There are many

first steps--

one

is outlined in

your

letter.

is to call or visit Steve Szara and get a picture of the
present studies in progress, and the possibility of undertaking such
a study in India. I would also suggest that you write to Dr. Chopra
after reading his report and asking whether he would cooperate in
other studies. Perhaps someone from NIDA is already there. If not,
and Chopra is willing, I think it should then be possible to formulate
Another,

a proposal based on his observations (much as we did with Miras'
observations) with the additional data from Szara (and perhaps

Petersen). Finally, you would do well to visit a number of
the others still interested in this question, to get an idea of
what the present thinking of the chronic cannabis syndrome is:
Sidney Cohen, Vera Rubin, Henry Brill come to mind.
Bob

r
.r-

-&lt;.

From my awareness of the issues, the NY Ac Sci volume
provides the basis for the questions to be answered. The Greek, Jamaica,
and Costa Rica studies are internally consistent in major matters——
only the Indian and Egyptian data are incongruous and I think that
this is the area of study now.

vw,‘-—r‘.-'Hw.fyr

I said in Irvine, I would be pleased to help you develop
such a study, and when the time comes to negotiate with NIDA or other
As

agencies for support, I have

some experience wﬁgich may be helpful.
will need a social-anthropologist or anthropo-sociologist in
addition to your psychiatric background. If you need a psychologist,
and I think you will, then one aware of cultural differences in
testing would be the one to identify.

You
.:

1""vale

Mm

w-

--~

1:"

us.

puma-warm

_.
aw."

Separately, I am sending you a copy of the
I think the questions come from it's papers.
My

NY

Ac

Sci volume.

best regards.
Sincerely yours,

cur—or.“

.

-

vacuitwn'ﬂrnrxx

"v‘

‘

Max

Pink, M.D.

Professor of Psychiatry

.

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                    <text>,7,

W. w

~

v.7 pr...- ——m
-

an

)

v n.“ ~v..~w~-w.ﬂu are—v. ....

.,

..:..v..

..

I

.7

,_ e

, ..

M.

.77.

September 15, 1977
John B. Adams, H.D.
College of Medicine

University of Florida

Gainesville, Florida

Re: Ali Kestiner, M.D.

Dear Dr. Adams,

It is a pleasure to write the following regarding

my

association

with Dr. Ali Keskiner. I first met him when he came to Missouri and joined
the staff of the Missouri Institute of Psychiatry, about 1963, at a
time when I was Director of the Institute. He accepted a position of

clinical responsibility in managing one of the Institute's 25 bed units,
and undertook clinical research in that population. In the course of

became interested in the aftercare of psychiatric patients
and he became the principal investigator in a long-term community treatment
project. At the time I left the Institute, in 1966, he was a leader of
a clinical team and a responsible researcher. I thought highly of his
work, and invited him to come with me to New York.

his work, he

His principal studies were in the clinical effects of new
in treating the mentally ill. At the time, our interest was
in the application of fluphenazine enanthste, and it was Dr. Keskiner's
contribution to demonstrate the efficacy of this compound for the
maintenance of the long term mentally ill in the community. He showed
the contribution that the drug could make when combined with social
casework and adequate aftercare management. His work was honored by
compounds

a number of awards.

effectively pleasant,
all my association, I fcund him friendly,
and firm. He
broad
His
knowledge
is
clinical
responsible.
relaxed,
relates well to staff and patients and his unit was often used as a
demonstration unit for visiting dignitaries. In his research protocols,
he was innovative and particularly sensitive to the personal needs of
the patients. He is a sensitive clinician and a well ‘brgenised teacher.
On a number of occasions he lectured to the residents and his lectures
In

and

were well received.

faculty,

I

and

am

pleased to

believe

he

recommend him for an appointment
do a commendable job.

will

to the teahhing

Sincerely yours,

.

Max Fink, M.D.
Professor of Psychiatry

�</text>
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                    <text>~

wwrﬂ.n

nr—wm:

may

,

September 16, 1977

Russell Gardner, Jr., M.D.
Department of Psychiatry—Behavioral Science
University of Nirth Dakota
Fargo, North Dakota
Dear Dr. Gardner,
&lt;

-.

-

wimp-r"

v;‘-“vp-«v'r\d

.T

.

ens—«”1...»

A_"W-5--n-&gt;

""2""‘Rr'W5-src

""er

"xv-'-

W

~xr&lt;rvz1rv~.,,.w

”Wyn-um

-v-W~_;r-u

_

mmm—yw.m

regarding

I
my

pleased to respond to your request for information
associatdon with Oliver Nikolovski, H.D.

am

Dr. Nikolovski was a member of the staff of the New York Medical
College from 1968 (9) to 1972 when I was Director of the Division of
Biological Psychiatry. He was a clinician in the out-patient programs
with a keen interest in research. Soon after he joined the clinical
staff, he approached me for collaboration and I developed a number of

clinical projects in
I found

which he was an

active participant.

to

be a meticulous worker, carrying out the
He was reliable and thorough,
and each case he developed, he developed carefully and according to
the design of the experiment.
He was liked by his patients, and he was
able to relate well to his associates. On a few occasions, I attended
sessions in which he led the resident trainee psychiatrists through some
clinical conferences, and I found that he summarized the case findings
well and he stimulated considerable discussion among the participants. His
diagnoses were clear and occasionally dogmatic.
him

details of the protocols with exactitude.

Dr. Nikolovski is a reliable worker who carries out instructions
is neither innovative nor adventurous, and if he were placed in
a position in which his missions were spelled out clearly, I believe he
would be

well.

He

a productive member of the

I

trust these

comments

staff.

are helpful.
Sincerely yours,

v‘m’wav.

'm-r

th‘l—I'

m

WWVW

.

ﬂax Pink, M.D.

�</text>
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                    <text>"'1

.September 16, 1977

“U

swnww'wr“‘

C.B. Schorer, H.D.

Lafayette Clinic
951 East Lafayette

Detroit,

“We

rmwsvﬂ.

Michigan

Dear Dr. Schorer,

—u.-mwr'

regarding

m.“

'7‘“.

'WIIV'V1W

mm&lt;

#8207

I

am pleased to respond to your request for information
association with Oliver Nikolovski, M.D.

my

Dr. Nikolovski was a clinician in the out-patient departments
of the Department of Psychiatry at the New York Medical College at a time
when I was Director-of the Division of Biological Psychiatry. Soon after
he joined the clinical staff, he sought me out to develop clinical research

projects.
ﬂew-M:

developed a number of studies together. I found him to be
a meticulous worker and he carried out the details of the protocols with
exactitude. He was reliable and thorough. He was liked by his aptients.
He taught resident psychiatrists the elements of
descriptive psychiatry
We

and

his reputation in this role

was good.

is a reliable worker who cartees out instructions well.
is neither innovative nor adventurous, and if he were placed in a
He

He
Inn—‘—ywj'Imum—"J_nwuu‘mmw.wwWI‘NWWT

position with specific missions,

the

staff.

I

trust these

he would be a most productive member of

comments are

helpful.
Sincerely yours,

'vw—m‘

,

-

.w

,

Max Fink, H.D.
.Professor of Psychiatry

�</text>
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                    <text>.,

ans-N. .w—n-e wwx—nw—ur

w

. —. "may

wwm

7m..‘wv

-

au—wv—w

September 29, 1977
rammwr—v'w'

‘m

Richard Resnick, M.D.
York Medical College

New
5

East 102 Street
York City

New

Dear Richard,
While

in Holland a

few weeks ago, following up on my

interest in the peptides that may affect brain functioﬁ, I was
presented with the enclosed reprint and asked whether I thought the
data warranted further study.

After reading the report, which shows that the administration
of a peptide derived from vasopressin will reduce the self administration
schedule of rats bar pressing for opiates, I bacame very interested.
It seems that this peptide has the same effect on self—administration
of opioids as the administration of an opioid; yet the compound has
no analgesic, respiratory, or sedating effects.

It

would be of

My

regards.

interest to determine if the compound
relieves drug seeking behavior in opiate dependent humans.
I presented the problem to Al Freedman and he seemed interested,
suggesting that I send you the reprint and arrange that we meet soon. I
am scheduled to teach at the College October 5 (8 to 10 p.m.) and
again October 26. If either evening is suitable for you, call me and
I can come in about 3:30 or 6 p.m. for a chat.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>vw. V. .

sm

«v

wwww' W'v—W'w‘w'mr ﬁ-xm'W'Wﬂu-u

*XWW~‘:.~.-n-ghw'mnwnwulwaw; er~-‘-m—

September 30, 1977
Raphael Mechoulam, M.D.
Hebrew University

Jerusalem, Israel
Dear Raphael,

I have checked into the facilities available to me to
CBD. At this time,the hurdles are rather

undertake the study of
high.

Last week, I met again with Professor Alfeed Freddman, my
former chairman, and he reminded me that the research unit vas still
active under my associate, Dr. Resnick. I spoke to him today, and
he seemed interested in the project. I have, therefore, sent him the
file or letters and reprints, acknowledging that he can count on my
cooperation for any analyses that will have to be done.
Dr. Resnick is the principal investigator in all the studies
at the College since 1&amp;6? into the activity of the narcotic antagonists,

cyclasocine and naltrexone. He also assumed responsibility for the
studies of methadone and levomethadyl, and has been a student of
the behavioral and central effects of cocaine.
and

I

I have asked him to write to you for any additional information
hope that he will be stimulated to undertake the study.
My

best regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

max

.

:b‘w-‘I-wnv'r-

x

.m—

�</text>
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                    <text>v

-

.

—.....

warr

~

»

w

..-.w..

.7

v“

we. ‘m'V‘I . y; V’v‘w

gum msww “H”

_""'Y'

,

m—~u

,

m‘mw-WaI—lv‘m—w, “WM“..WWM-mm~-WWW\YV,m- .- . wwx—v-u... ,,.w.‘,m.._wh.._m.

“r,

get-.m'wrswrm'qu

FHA-me...

September 30. 1977

“r'w-up

;

.

Richard Resnick, M.D.
New York Medical College

New

York City

Deer Richard,

In June, I received the enclosed material from Dr. R.
Israel. I could not decide whether I could look at
the project then, with the summer coming on. It is clear today
that you are much better equipped to do the study then I, and I
Mechoulsm of

sending the material to you, hoping that you will become interested. we will do whet we can to assist you, but the need for

am

special licenses is s hurdle that is too great for
I did contact Drs.

me

at this time.

Brande end Szers, and they were unresponsive.

the EEG point of view, the study would be of special
interest as another test of the EEG/behavior associstion hypothesis.
The clinicsl features are the most interesting, however.
From

My

best regards.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>'l'-‘Ww-'2-m r.

.

..._

I.

,. ,

September 30, 1977
John C, Kramer, M.D.
California College of Medicine

Irvine, California

vawllw

Dear John,
n

.

study
have re—read your suggestions regarding a hashish
following
the
with
comfortable
a number of times, and now feel
comments.

I

related
classification of four classes of hashish
It
nature
in
How
occur
many types
psychoses is a theoretic one.
that
possible
is
answering.
It
is this latter question which needs
Spuief and other
Chopra,
and
that
exist,
psychoses
the different
astute enough
been
have
example)
observers (Knight in Jamaica, for
to do so. It
failed
have
to describe them whenﬁiestern observers
all) these
(or
Do
any
is this latter point that needs follow—up.
in users ?
exist
mental states
The

T

theoretic types of hashish related

who
suggestion, that of finding individuals
and re-exposing them
have recovered fram a cannabis related psychosis the question: Cann
to
to hashish, is a good way of getting an answer
mental state 7 But, what

The second

cannabis inhalation precipitate an altered
individuals to a pathogen
of the ethics of exposing presumed 'sensitive'
be
built in to protect
could
How about the safety ? What safeguards
?
even if the acute
And,
a subject who becomes psychotic (again)
complains of
the
what
patient
if
episode is treated successfully,
?

recurrences ('flashbacks')
I would
As for the 'backtracking' pf Souief and Chopra,
that hashish
not assume that they have given up any of theirandopinions
that theta are a
psychoses,
is dangerous, that it precipitates
and euphoria
stimulation
variety of mental states, from transient
of hashish
result
a
as
which
occur
to a schizophreniform psychosis not unique for others subscribe as
are
use. In this opinion, they
assuredly, and my co-worker, Stefania
H.
Brill
and
C.
Miras
strongly:
that needs checking. Since we
probably. It is precisely this issue
whose psychsiisits
are unable to define a population of psychotics
those patients whom
of
study
perhaps a
directly related to cannabis,
Hence, the suggestion to
others see as related would be more useful.
happened to Martin
examine patients with Chopra or Souief. (Whatever
psychoses
Keeler-- he has described a series of cannabis precipitated

?

�-v_

-—,...,_,., ......_

v..." w—n-wr «

v-«rer'mrv-v-IW‘mm'alp-S'rIJ-IA ,pr‘rVV‘IKw—w'dﬂ-v-

John C. Kramer, M.D.

.....

"art's:

,_,

q—‘WYer-r

m.

r

«7-. hw—v—w-.."

September 30, 1997

___,_

w Ver-r «my (—«W‘u....~.
—r

..

"as...“ —...v r...— ewvm

.......... page 2

in students in South Carolina 7).
similar issue is developing about the use of another
'hallucinegen', khat. Khat is a plant derivative which is chewed
by the natives of Abyssinia, Sudna and Arabia for its 'stimulation'.
A

I

it

described, khat is used much as we use a coffee
break-- a relief in a set of monotonous chores. The plant is pro—
scribed in these countries. One member of our faculty, Professor
Krikorian, is a national expert and has urged me to undertake a
study of its pharmacology, physiology and to go with him (after
the present wars are settled) to Abyssinia. You may want to look
up what you can find first, and if the matter interests you, I
As

have heard

will send

.

you my

file.

,_...v..,,.e.

begun a volume on convulsive therapy, and that
is keeping me busy. The EEG studies are going well, and I now have
one good clinical unit at the VA which seems able to do good work.
Mostly with schizophrenic veterans, a complex group to assess. But
the work is interesting.

I have

$7,,

w

w“

“mm-mm"

Thanks

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interest.

My

for your ideas. I
best regards.

hope the responses are of

""V-m7m'

Sincerely yours,

r—w—m-

"W-‘W'v‘el‘f'

Fink, M.D.
Professor of Psychiatry

Max
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                    <text>Mr. Robert N. Ubell
New York Academy of Sciences
Two East 63 Street
New

3..

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.
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mun-2r

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York City

Dear Mr. Ubell,

Congress of Psychiatry was welcome.

are figures of the actual EEG records, of the changes associated
with changing blood levels, as well as the type of tables described
inthhis report which can be prepared for you. Also, it would be
useful to present these techniques in the context of clinical electro—
encephalography. We use the same instruments (the EEG) but we do not
assess the paper record; rather we focus on the mathematical data
which is provided by the digital computer data reduction system.

“we've

Wim'm

further note could be added on the relations of these
to the parallel studies of the averaged evoked response, the
A

&lt;

"

letter regarding the presentations at the

World
must
I
admit, however, that I
did not attend the Congress, having been invited to give an address
on the same subject at the International Congress on EEG in Amsterdam
at the same time. I enclose a copy of the paper presented at that
meeting for your information. Rhe report is technical, and I believe
that a more general version can be written for The Sciences. There
Your

'w-

w

methods

sleep

EEG

and the contingent negative variation-— data which I

elected not to present in this report.

«‘4

WWW—1'":

2—1.5.va

.v1:

Mum

us

urn-«w»;

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.1wa

October 19, 1977

that

Let

interest

me

take this opportunity to suggest another topic

you as well. In 1976, the Academy sponsored a conference
on Chnonic Cannabis Use, published as vol 282. Since then, the Greek
material has been published (Hashish~ Studies of Long-Term Use, New York,
Raven Press) and the data from the Costa Rica study have been submitted
to the same press. The Jamaica data was published a few years ago (Ganja
in Jamaica).Mouton Press, Paris). It seems to me that these studies are
may

remarkably consistent in failing to find evidence of long term damage
after the use of potent materials. Perhaps hhere is a story in it for

The

Sciences.

Sincerely yours,

MPG/a,

:-

V’E'ﬂl’!".(

Fink, M.D.
Professor of Psychiatry

Max

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_

f

,wm

m%&lt;_

8’

/
4

November

1, 1977

Gerald Roskin, M.D.

Hillside Hospital

Glen Oaks, New York

Dear Dr. Roskin,

Grand Rounds as

I regret that I will be unable to attend the
originally planned on November 23.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

\

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                    <text>November 5, 1977

John C. Kramer, M.D.
California College of Medicine

Irvine, California

92717

Dear John,

I was glad to hear of the work of J.G. Kennedy. I had
of it, and suggested the study only because I had been
encouraged in it by Dr. Krikorian. Obviously, Kennedy is a better source
of the latest information on qat. (Incidentally, do you think I can
use 'QAT' in scrabble ?)
not

known

Your analysis of the Chopra and Knight data is excellent.
these reviews I still believe the question of what they were
describing is active and their samples should be re-examined. I do
not know what NIDA would do_with an application now, but they are
obliged to respond to every formal request for funding. From my past
experience, a visit to Steve Sears and some of his co—workers is a
must before a study is contumplated overseas since the funding will
have to be of a contract form. It will provide a way to catch up
on the latest studies and to find out what is in the pipeline (like
From

it

If you can visit Washington, do so. Or, is
you may attend the next meeting of the ACNP in Puerto
Rico (December 13—16), when
is likely that Sears and his staff will
the study of Kennedy).

possible that

be present

it

?

I know of the ocualr tracking test only what is popularly
the literature. Don Klein asked for a small grant from
Stony Brook in 1975 to get the equipment to do a study. Perhaps he
is up—to-date on the dindings. However, it is unlikely that a new test
could be a definitive basis for a discrimination, until at least there
is a large body of acceptable data in known schizophrenics, and this
I think is lacking.

known from

I have no trip west scheduled ahead of me now, so I hope
can get together when you have an excuse to come East. Let's make
soon.

we

My

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

it

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                    <text>.Wr

w

v“'

-m"wrv-Awn—untn‘-’IAI—u4uw‘r'

November 18, 1977

»
.

-

'

Dear John,
“rthm1L"v&lt;~l".—"

nu

luv-w—

x

"

fur-n

"Pam

to viiit Jamaica is excellent. The only
with Michael Beaubrun, whom I visited in 1970 or
1971. While he agve the EEG part of his study to Korein and Karacen.
contact I had

we

Your idea

was

have remained friends, and I

from you. He

is the (or

which the reports

was) the
emerged.

trust that

he will respond to a letter
director or the Bellevue Hospital from

w

u
.

'u-

rww'mmz'nrwu1—‘clrIvmv'mwm.

you

will let

If you

me know

can see your way to return via

and we can reason the problem

New

York,

together.

I

hope

I'm busy these days wrestling with ECT again. I have
a number of questions which I think could be answered by yet another
study, and I am planning a VA collaborative study. Otherwise, the
programs here are purring along rather quietly.
my

best regards.

“mmywmwﬁtvmnn

Sincerely yours,
Max

Fink,

M.D.

�</text>
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                    <text>”.17.,

w

.v-a-gw-yn...

November 18, 1977

Michael H. Beaubrun, M.B.B.Ch.
Department of Psychiatry
university of the west Indies
Kingston, Jamaica
Dear Michael,

our project in Athens
and the report has been published earlier this year. At the 1976
meeting at the New York Academy of Sciences, there was agreement
among the reporteds from Jamaica, Costa Rica and Athens on the findings
of the three studies. The reports of Sonic! and Chopra, however, were
discordant.
As you know, we have completed

former associate of mine, John Kramer, has been active
in research in opiates and amphetamines. He was a consultant to Jerome
Jaffe at BAODAP. In some discussions last fall, I enchuraged him to look
‘at the discrepancy between the sttdias reported at the Rev York Academy.
A

s dialogue.and we have been struck by the
reports by Dr. Frank Knight from your Department. John has written to
Dr. Knight as he is planning to be in the Carribesn for a holiday in
we have

carried

on

February.

assist

in
of the cases reported from your Department, cases with
the syndrome of cannabis toxicity and/or cannabis psychosis. It may
provide him with the basic experience upon which to design a study
to resolve some of the discrepancies noted earlier. I am sending him a
copy or this letter, and will ask his to vrite to you directly.
seeing

some

I am'writing to ask vhether

Many

you could

thanks for your assistance, and

my

him

best regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>WW.

.7“

.

y,

x

v—r-u.

.«rw ~»r-wu.-_——nww- ‘lu—P'r—KyH—IWrwm‘ﬂ—HnVn

mm.

“Mm.

vam-

m.

7“ mymw-wm.mmuwm w..."- mw...-n-—.

1...

.«w—n. wan-mun.“

.

-

‘ww‘F/W p":- w- n WWI-P. «nun-1w. -.v..——v-—.~
x

4»/
November 21, 1977

Nathan 8. Kline, M.D.
Rockiend Research Institute
Orangeburg, New York 10962
Deer Nate,

read the file on Dr. Vacant G. Joehi with some interest. As
observations, it is that INH plus Vitamin B6 served to
case of catatonia. The patient had two EEG records done,
receiving INH. There was a remarkable change in the EEG,
characterized by the appearance of generalized, dominant slow theta activity
which became more intense with hyperventilation. Dr. Joshi notes that he
has used.the combination in other schizophrenic patients with success.
I am not surprised by his report. It is consistent with two sets of
data. The response of catatonic patients is notoriously rapid when any change
is induced in the CNS. Thus, barbiturates, amphetamines. and BCT have each been
successfully used in catatonia. The most interesting is the latter, A recent report
by Breakey and Kala (British Medical Jounnal 2: 357~359, 1377) finds that
ECT-wcs remarkably successful in relieving more than a dozen cases of catatonia
after typhoid fever. The predominant finding in ECT in the EEG is the development
of high voltage slow waves in the theta range which are responsive to hyperventI have
I understand his
relieve a single
before and while
.-

.

ilation.

The other observation is that of the association of EEG and behavior
after psychoactive drugs. It is clear that any compound that alters brain function
witl show its effects in the EEG, and when such effects are observed by clinicians,
the EEG patterns will be clear and will follow predictable patterns. Dr. Joshi's
paper suggests that the high doses of INH which he is using do have an effect on

the

EEG

similar to

BC?

or antidepressant drugs.

It is not possible for us to corroborate Dr. Joshi's findings. We
could cooperate with other clinicians whb wish to duplicate his observations

by carrying out the EEG analyses on records collected in another site, if the records
are collected on tape compatible with our recorders. We also lack the funds
for a research fellowship at this time, although
is possible that you and the
other Research Directors may be making funds for fellowships available.

it

and I

for the opportunity to read this interesting communications
congratulate Dr. Joshi on his fine observations.
Thank you

Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

w—n—u—

�</text>
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-1

r7'zVI'.'Vrr"‘-VmVm'r'r’wvvrwwwlwunv‘

-.

December 6, 1977

wv-vvm

’—.-V&lt;7nr'm

1:

r
..,

mum.

w

runway.

"Wllrwu-V‘H.

..‘,..

ray

:1
1-».

V

Wm.

Abruzzi, M.D.

Fox Farm, Loon Lake Road
Malone, New York
Dear Dr. Abruzzi,

c.v. exemplifies a rich experience. As to your questions,
is difficult to know how to answer the first. For decades, various
it
authors have suggested that cannabis is associated with psychosis. Two
theories have been stated—- that cannabis is a psychotogen, and that it
Your

'1iberates' psychotic tendencies that already exist. The issue is not
whether cannabis is a psychotogen, for that issue is spurious. Since there
is good evidence that cannabis inhalation alters brain function, it is clear
that with such alteration there must be changes in behavior and there
is no reason why such changes could not be manifest as psychotic symptoms.
After all, the definition of psychosis is in the eye of the beholder, not
in the symptoms themselves. , If you have some additional data, then why
not follow established custom and present the findings and the controls ?

it

became clear
At the New York Academy of Sciences meeting,
under
and
Costa
controlled
Rica,
the observers in Greece, Jamaica

that
conditions, could not confirm the development of psychosis in long-term
users. But reporteds from India (Chopra) and Egypt (Souief) did say that
psychosis was common. There is a need for someone from the U.S., with the
same support that the other fOreign studies obtained, to go to India and
Egypt and confirm

their observations. Perhaps,

a mission through your association at

studies

and would not do another.
Good

luck in your

summary

NYU.

I

you could undertake such
have done my bit in such

of the recent studies.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>{I

i
g

“um-umw-www

"v

rm

'.

Dcceﬂber 12, 1977
Tb: Antcl Kerakovitz
From: max Fink.

M.

SubJect: Eugene

MbDermott

D.

Departmcnt of Psychiatry

I have been a user of the Media Services for the past year.
In this time, I have been pleased with the variety and quality of

the services available. Mr. Habermott has always been courteous
and relidble in his service, and the quality or the work has been
most satisfactory. I comment him, and his cedworkera for their
efforts. and trust that their sarviccs will continue to be
available.
MFz'bc

�</text>
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                    <text>v

”A

.._,

V

yum-awn

».--

rmnwwmwrw

ryrt’ww‘wwtwtvmj

January 3, 1977
Daniel X. Freedman, M.D.
Chief Editor
Archives General Psychiatry
950 East 59 Street
60637
Chicago, Illinois

Re: Ms “02% (Revided)

Dear Dan,

In re—reading the draft of the article, "Efficacy and
Seizures (EST)in Man", I found a number of
Induced
of
Safety
of the discuss-on and comment (pp. 30-35). I
in
the
text
errors
have corrected these, and in the event the article meets the
standards of the Archives, I ask that you use this draft for

publication.

Thank you

a healthy 1977.

for your consideration,

and my

best wishes for

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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January 25, 1977
Dr. Derek Murphy

Medical Research Council
20 Park Crescent
London,

WIN HAL

www.m-ry—

Dear Dr. Murphy,
"WKLIKVUI’w-vuwv'v”!

.,-c-.m.o~w

to England

While I know the time is short, my plans for my visit
have been finalized this week. I shall be in London

on Saturday/Sunday, February 12/13. If there is merit in
meeting Saturday morning, I can arrange the time.

"-r

«"177

I have requested accommodations at the Athaneum

Hotel on Picadilly Road, and a message addressed to that hotel
will reach me Friday evening.
My

regards.
Sincerely yours,

mm")!

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Max

�</text>
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March 1, 1977
Mr. P. Rageth
we,“

an“.

S. Karger

AG

Basel, Switzerland
Dear

Sir:

"EEG

I have reviewed the page proof of the article,
and Task Performance after ACTH u-io in Man". There are no

-v-...»~wn~v—me._muvr

remaining corrections except the following:
~v

f
a,

V

m.wv~—w.q-

Dr. Halter Sannita has returned to his native Italy,
may be more helpful to list my name, Dr. M. Fink, as the
addressee for reprint requests (bottom of page 882). It is more
likely that cards addressed to me will be delivered properly.

it

As

"rm

.w.

a.

.
'Mw»

Sincerely yours,

w_-L—w:‘«.~=-wmvw

My,

”mun

"an.

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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-v-

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«n

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».

March 14, 1977

J. Eric Jordan,

Md).

W

of
admit}!
San Ant-nun, Team

78284

DearDr. Jordan,

Webacamintmstadinﬂmmlatimsbemﬁm

axiom
mtimmlsantsmyearsago.mrinitialsuﬂieamdme

activityofvariws
wiﬁubmaodhmhxewdhzepmandbmampm~tobefoﬂamd
profiles, blood levels,

latelybysuﬂiesindipl‘mylmdantoim'mediazqmblmd
levelswemdcuby

m.mwmm3dmrtzof
MKuttoEOornell Mmity.
Hofﬁmrmm: tmm1bjbr.
mtirstderqaorthasbampmaWinMIth:
mmﬂmbeirxgwrittanm.
Mmmtmstingauﬂyistmtofnmmwa
mliammlmemfmndamfmmmwhmhmmwm
atbloodlmlnabave7mcgbutmthelmv. 'matstxﬁyiain
WSpresent

Idomthmofotmrsintemstedintrﬂsvmkatr

whose

interest is focusmd m anticonvulsants.

mmymaremtmquork,maﬂvisitarﬂm

mnelmyaumtmhaveﬂme.

Sincerely yours,
Max

Fink,

PLD.

Professor of Psychiatry

CPI, 20:184-191., Aug, 1976.

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                    <text>March 18, 1977

Governor Hugh Carey
Albany, New York
Dear Governor Carey,

I am writing because the newspapers say that you
signed a special bill to support medical education at the medical
school in Tel Aviv; and that this legislation provides special places
for students from New York State, presumably Jews.
a Jew and I am chagrined that such special legislation
was signed. I am ebven more chagrined that the legislation was
proposed by fellow Jews and supported by Mr. Landes from my
community. I trust that the precedent will not lead to the
expenditure of New York State funds (in short supply, it seems)
to support schools in Rome for Italians, Madrid for Spanish,

I

am

Dublin for the Irish, etc. If there
should be withdrawn.

bill, it

is

some way

to withdraw yhis

more places needed for New York State students,
perhaps the development of Stony Brook could be advanced. We have
admitted 48 students during each of the last two years. Our facilities
are limited, but perhaps the funds could be replaced (those that we
are told have been cut) and that such expenditure plus the Israeli funds
and others yet to come would be sufficient to increase the SUNY class ?

If there are

I am writing not as a member of the SUNY faculty, but as
a citizen of the State, as a parent, and as a Jew.

Regretfully,
Fink, M.D.
Professor of Psychiatry
Max

39

Areligh

Road

Great ﬂeck,New York 11021

�</text>
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                    <text>v- *Wtwwzwx

_

. .-

Jamar-”No---w.--;..u.v-umvw.“I'm”'1n3'w14'f‘m‘7l'r‘m-ﬁarm-saws. «mm—"7m.y’rm‘ﬁs-‘W rme‘yun-wnrmum

~.—'

.7 -»—-u«

.

awn w "W" r-l'W'e-V'Iu

U‘vm’ “Jr—1".Yr'wrn-‘J‘W

w-p

n

xswvnuaw-ww.» an

'7

«w

”up-v.

--,~,——~vn-——~m-1-uvwxvu-.—

March 18, 1977

Assemblyman Irwin Landes
New York State
Albany, New York
Dear Irwin,

I am chagrined to learn that you have been in the forefront
in the support of the expenditure of New York State dollars for the
medical school in Israel. No matter that the goal is a good one; or that
Israel. In this time of
as a Jew, I personally support good deeds in New
York dollars to
limited funds in New York, how dare you use
?
in
foreign
country
a
support a venture

action is even more deplorable as a model. What will
Support medical schools in Roma for the Italians, Madrid
for the Spanish speaking, Dublin for the Irish ? And why not ? Are
the Irish, Italians, Polish, negroes etc. not as entitled as the
Jews to special medical attention ?
we do next

wn~av~pwneg~r~wwawumm~w

.
v

~

‘

Your

?

Even worse, we have a medical school at Stony Brook with
only 48 students in a class; with its funds cut this budget year. Why
not storm the Governor's office to increase the funds at SUNY and
force the acdeptance of more students there before you open the

Pandora's box of special legislation for the Jews in Israel?

3

w

u—

»7

m-u

w-n;

..

response
him

for

was
ﬁim

The news reports said that
to veto this special bill.
to change his mind ?

Governor Carey's
What payment was

initial

offered to

v-r'.w'

'_-"v-.~'p-'-

—,

W.-.”

.v—v-

I

distressed.

already have to much emphasis on
quotas and special legislation for minorities. Bilingualism is a
road that we in New York will find rocky in the next few decades.
Now, your special legislation in Wsrael. I am chagrined.
am

We

M

Sincerely yours,

w-w—‘H-“Mvmn

-

Max

.,-

wmzcw-w-r

39

Arleigh

Great Neck,

Road
New

York 11021

Fink,

M.D.

~r,a~.wx—.v—

n. n-vsxr .z-‘ra ,—

�</text>
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                    <text>March 19, 1977
Mr. Robert Lyons
York Academy
2 Est 63 Street

New

New

of Sciences

York City

Dear Mr. Lyons,

I have received a large number of reprint requests
inquiries regarding the purchase of the volume 282 on
Chronic ﬂannabis Use. I am writing to ask whether the Academy has
printed descriptions and purchase order blanks for this volume. If
yes, I would appreciate about no copies. These will be sent to the
requesters with the reprints that are available.
and

Parenthetically, I recall that our agreement

the editors would receive
3 copies.

5

was

that

copies of the volume. I have received

I hope the volume is well received. From the reprint requests
already in hand, I would say that the interest is quite high.
Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

�</text>
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                    <text>x
law

a»

40"me

:nnsvznr

w—r

~,

Inna-w-

wy...

‘I'“(“'.

w“.- ._,..,.,,W.,~r.

vlvu/anH.

-.,

‘nﬂV‘Lvr‘r'vvv ”H... a.

,

,

.

.

.,,

.,_.,,.,....~a.

n.—

.mmw—l-w n»,

_.

3;.

:‘x-i

'1'.“er

{mtgyr‘rw'v r.7v..lr'-"t:\1vw. w.

April

ll,

v'uﬁrh‘avv‘n""!v~n'v~m:

nay-aw

,-

.

-

«

,

.

1977

Dr. Francis C. Colpaert

Jannsen Pharmaceutica

Beerse, Belgium

B-23H0

Dear Dr. Colpaert,

It has been a number of years since I was directly
involved in studies of narcotics and narcotic antagonists, so that
your questions came as somewhat of a surprise. Nevertheless, I
shall try to answer as best as I can.
subjects repeated doses of heroin
that we did not observe
tolerance. When we gave oral doses of methadone, tolerance developed
rapidly, and when we gave such subjects injections of heroin, we
were able to observe cross—tolerance. Depending on time after
oral dose of methadone and dine, subjects either could or could
not distinguish placebo from heroin. They generally used as
cues their subjective feelings of relaxation ("high") plus the
change in skin tingling, respiratory slowing and occasionally
the relief of irritability. When we gave patients levomethadyl,
they developed tolerance as they ddd to methadone, and the same
pattern of cross tolerance to heroin, with a different time course.
When patients who are tolerant are given a single dose of naloxone
or cyclazocine, a severe withdrawal syndrome is precipitated. These
are the types of experiments we carried out, and based on these
observations I would think the answers to your questions are as
When we

gave

intravenously, the timing

was so spaced

follows.

1. The discimination of a narcotic from a placebo

is dependent on dose of the narcotic, state of the subject (tolerant
or 'clean’), and time in the withdrawal period that the narcotic
is given. If repeated administration is rapid (doses within a few
hours of each other, as in three or four times a day) then tolerance
is seen easily.
2. Users discriminate

active

from

inactibe material

their central effects mainly: relaxation, euphoria, drowsiness,
decreased irritability; and to a lesser extent from peripheral cues.
from

also use the relief of withdrawal symptoms
allowed to devlop.

They

if

these have been

m

-

t.»

H" -w-

w;

.—

mn. v.

~

_..--

�q;

(an.

-

-Wm—_~&lt;

-

Dr.

colpaert 0000000000000mch11’1977 000.000.000.000 page2

to tolerance.

3. The euphoric

I

trust these

effects of opiates are subject

comments

are helpful.

Some

years

ago, 1970 or 1988, I visited Beerse seeking some undeveloped narcotic
antagonists as werwere then hoping to find an improvement on

cyclazocine. I remember with pleasure the cooperation of the
laboratory personnel, and I am pleased that your work has continued.

My work at the New York Medical College continues
under the leadership of the chairman of the Department, Professor
Alfred M. Freedman. Should you wish some additional information

regarding their recent experience with heroin, naltrexone, etc.
you may wish to write to him.
Sincerely yours,
Max

Fink,

M.D.

Professor of Psychiatry

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                    <text>April 13, 1977
William
The
#89

J. Darby,

24.13.,

Nutrition Foundation
Fifth Avenue

New York

Ph.D.

City

Dear Dr. Darby,

I want to thank you for sending me the many reprints
describing the studies of the influence of food additives on nehavior.
These have been helpful, and at present I am working through a number
of suggestions for a protocol for the study of chomolyn sodium in
hyperkinesis. I have the agreement of the clinic at Hillside Hospital
to undertake such a study this summer, and we have obtained some
encouragement from Fisons Ltd.

Should something come of the project, I shall
Again,

my

let

you know.

thanks for your help.
Sincerely yours,
Max

Pink,

M.D.

Professor of Psychiatry

�</text>
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                    <text>rump-Fwy.

:wWWTm"

nnl'wv‘rz'rw‘umr

.

_

.

wwwrmv-mmmrw—survWat's; 31"!- --v Wmmuwm—mv‘

V

.i

April 13, 1977
Dr. Thalia Harmony
Habana, Cuba
Dear Dr. Harmony,
Than you

for your interesting reprints

regarding the citation in the

CHAN

volume.

and the question
I note from your papers

that E. Roy John has been one of your preceptors. In the CHAN
discussion, I was citing the many advances in this country in the
development of special computers for diagnosis (the work of Harner,
for example); the use of averaged evpked potentials for the identification
of brain damage (here the work of John is a fine example); and the
use of cross correlators (the work of John is still the best example).
In the latter reference I was also interested in the studies by Leonide
Goldstein. There are surely others but they do not come to mind
readily, although I recall similar interests by the school at the
UCLA Brain Research Institute (Adeyyand his co—workers).
.

i
'

is far

studies
reflected in your studies. We emphasize the application of the EEG
to the definition of drug effects-- a good example is the paper in
My

work

from the basic neurological

the CHAN and that of my former co-worker, T. Itil.
question regarding that study, please write again.

If

you have some

.Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>STATE UNIVERSITY OF Nii'W YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

3I
Q

Department of Psychiatry and Behavioral Science
Psychopharmacology

——

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

April 27,

Michael Natale, Ph.D.
College of Physicians

Columbia University
722 West 168th Street
New York, N.Y. 10032

&amp;

1977‘

Surgeons

Dear Dr. Natale:

scientist who may become interested in
Dr. DiBianco at Misericordia Hospital.
is
linguistics
The only

has applied for an NIMH grant to study behavior changes
in patients undergoing hemodialysis. I sent him to Dr.
Jaffe for advice.

He

You may wish to contact Dr. Joseph Mendels at the
in Philadelphia. He is a biological psychiatrist with
wide ranging interests in novel methodologies.
Good

VA

luck.

‘Sincerely,
Fink, M.D.
Professor of Psychiatry

Max

MF:fg

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                    <text>or may YORK AT STONY BROOK
Health Sciences Center - School of Medicine
STATE UNIVERSITY

3’

3

’

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

April 27, 19773,

Bernardo Heller,

M.D.

2323 Van Buren Street
Apt. 201
Hollywood, Florida 33020
Dear Dr. Heller:
and

Institute

The

it

now

opened the ward L6 in the

has 10 patients in three studies.

fall of

1976
Dr. Asnis is

the ward chief, and Dr. Ts'o will be the other staff person
in July. As you may have read, N. Y. State did not allow
any new positions for LIRI for 1977-78; and so, regretfully,
I cannot process your re—application at this time.

It

training

would be best for you to complete your residency
and meet the requirements for licensure in Florida,

try to-re—establish your research studies.
Best wishes in your studies. I trust I will have

and then

chance to see you at one of the national meetings.

a

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

Mszg

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

4/,

5

I)cpurnncntofPsychhnryinuchhavknalSdencc
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phonc25164®hL2447

.

.

April 27,

1977

Committee on Awards, Grants in Aid of Research
Sigma Xi National Headquarters
345 Whitney Avenue

New

Haven, Connecticut, 065ll

Gentlemen:

like to endorse the application of Mr. Jay Schneider
of the effects of ACTH 4—10 on the EEG and DC
recording characteristics in monkeys. I have known Mr. Schneider for
half a year, as he has been associated with Dr. John Stamm and Mr.
Oliver Gillespie in their studies of ACTH H-lO.
Mr. Schneider will graduate from the State University of New
York at Stony Brook in June, and is matriculated as a graduate student
in psychology at this University for September, 1977. During the past
year he has been an active collaborator in the studies of ACTH #10 and
he proposes to continue these studies next year.
His interest in the problem has been stimulated by Mr. Gillespie,
his
by
rand
readings. I have been a consultant to the project and in the
late fall, I invited Dr. Henk van Riezen of Oss, Holland to visit the
project at the University. The meeting was fruitful fOr it clarified the
direction of the research and the present work is an outgrowth of that
I should

for support of

.

session.

a study

'

studies of the effects of peptides on memory and brain
functions are derived from the work of David de Wied of the University
of Utrecht. I have been doing some of the human assays in my laboratory
and stimulated the present efforts by Stamm and his colleagues. The
significance of the work is well defined: the effects of ACTH 4—10 seem
to prevent the extinction of a learned response. It provides an interesting
opportunity for clinical studies in patients with memory deficits due to
aging and as a result of electroconvulsive therapy. We are pursuing both
leads clinically. The work proposed here should provide a neurophysiologic
underpinning for the clinical studies.
Mr. Schneider is working in a well equipped laboratory under
experienced and competent direction. The funds requested will permit the
present efforts to continue; to expand the measurements of changes
induced in the EEG and in DC recordings from brain areas not studied
well before, the prefrontal and infratemporal cortex. In the rapidly
expanding field of peptide studies, I think that these exercises at this
University will be most.helpful in understanding the effects of these
substances on brain functions.
The

Sincerely yours,

7L.»

Max

J’W

Fink,

M.D.

Professor of Psychiatry

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                    <text>AMHV

moor 2M7

May 129

John Donnelly,

1977

M.D.

Institute for Living

200

Retreat Avenue

Hartford, Connecticut 06102'
Dear John,

I am writing to request a copy of your presentation on
the status of psychosurgery, as presented to the APA in Toronto. In
addition, would it be possible to obtain a copy of the recommendations
of your task force on paychoeurgery ?
I am preparing a paper on the advances in the organic
treatments in schizophrenic for Lee Bellak and I would like to
cite your experiences.
Many

thanks and

my

best regards.

nm-uwmwwr-

.
.
am"

Sincerely yours,

Fink. M.D.
Professor of Psychiatry
Mex

�</text>
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                    <text>May

Gabriel Laury,

Box A

13, 1977

M.D.

Kings Park, New York
Dear

&lt;&lt;

.
.,

l
w

A.

-..v

‘VE'H'D'HVJJIwn-ffvgg

Gabriel,

I am embarrassed to put you to this difficulty. I
did apply for the transfer in 1975. and then promptly forgot.
Once, a member of the Suffolk Branch called to ask the reason for
my transfer, and I explained that I no longer participated in the

New

York

District Branch affairs, and that I wished to attend some
now that my principal site

of the sessions organized in Suffolk,
of work was the University.
I never heard

inn-7.“.

from the Suffolk branch

after that.

,

:-

.

the

&lt;A

w

New

Recently, I

was reminded

that I was still a member of
I resigned two years ago.

York branchu- a membership which

,
.mr»

.w

-::

'r-rux"

If there is some problem in accepting this transfer
application, please let me know.

lair—1‘1"

mnw.~m&gt;nx¢w—u

Sincerely yours,
Max Fink. M.D.
Professor of Psychiatry

�</text>
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                  <elementText elementTextId="103991">
                    <text>WVNV"

MW

:_’.m‘.’r,7‘,’:vrrﬁ‘rw‘t

«Lag-pom.«w.~W~wmm3v~vuuraw~m~zmmrmamw r

-

,nn .-vw§trx'-HEWFm¥1-MV1PM
‘

4' mi.- n

«~m

4...

av

May

”—7.7,

~v

m

.. m.

sw—‘ﬁ-nr' ~..

xnrvv‘».

—1-.-1-

um- ....,

w—m—

x

~

,

,

"x:

v'

v

.,

—--.

-..

23, 1977

JaneOtto Ottosson, M.D.
Sahlgrenska Sjukhuset
Goteborg, Sweden

,3
‘Fﬁ‘ﬂ‘

.
‘.-&gt;~

_,.

‘yu'l'an-

w.

-.-w

.JKT-r-wamwnm-s

Dear Jan Otto,
have an opportunity to
him
and
meet your son
on June 4. We will have
to care for
him
someone looking for
at Kennedy after his arrival. If
they do not meet, ask him to call my home - 516 466 sunnthe charge will be 10 cents and someone will answer and give
My

him

girls are pleased to

instructions.

r‘
&lt;--

&gt;1;

amuwwrmwmaw

w"

itt

of the APA has completed its work and
recommendations
has written a series of
regarding the use of ECT.
The recommendations will be supported by extensive documentation.
Some of the reports are completed and some are still in progress;
as a group, I believe they will be quite useful as both a reference
source and as a guide to further research.
The Task Force

.

Suva-“73:1:

m":

I read the program description for the World
it is very good. I am indeed sorry to miss

Congress and think

n:

still

The NIMH committee has dawdled and

at this

moment

is

indecisive as to whether it should devote the session to
the facts of ECt or to spend much time on the ethical and political
issues. Since the latter were the basis for my disagreement with
the committee, I do not feel so bad in having left them.
work has been extensive in reviewing the EST
process for the Task Force and for some other reviews: I now
have a cost/benefit analysis statement; a review of the myths of
EST; specific surveys of the use in schizophrenia and in mania;
a small study of the use in the Metropolitan New York area (which
I am sending to Gianomo today); and another theoretic essay. I think
I am now ready to get back to some clinical research.

regards.

My

own

We

look forward to greeting Hans in

New

York.

My

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

best

m

.— ..—

“4-4. .—.&lt;.-.-

4

-.

--

H

,

.-

--_

.., ur—

�</text>
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              </elementText>
            </elementTextContainer>
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                <text>1976 </text>
              </elementText>
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                    <text>-.
”n.5,

"mtw—WWWWW'HV“;W

May

Richard Shader,

23, 1977

M.D.

132 Homer Street
Newton Center, Massachusetts

02159

Dear Dick,

I have been using the sedation threshold as a diagnostic
1955, and have not had any complications associated with
this procedure. Recently, I have re—instituted a study program for
another assessment of this test, using the RDC as diagnostic

test since

criteria; in the belief that much of the difficulty with the original
test data was inherent in the lability of diagnosis, and not in the
specificity of the test. To do the present study, my associates

Drs. Martin Heymand Had Timothy Ts'o have prepared and filed a
protocol which has been approved by the appropriate review committees
of the VA Hospital, Northport, and the Long Island Research Institute.
In both protocols, permission has been given to carry out tests in
patients prior to definitive treatment with drugs or EST, and to
repeat the test periodically during the treatment course to assess
the changes in the test with cahnged behavior. Dosages of amobarbital
up to 1.0 gram are given at the rate of 0.5 mg/kg/HO seconds following
the descriptions of Shagass, up to nystagmus, slurred speech and
defined EEG cahnges (higher voltage 20-25 Hz spindling).
In filing for these studies we referred to the extensive
data reported by Shagass (for reference see my summary in Katz, Cole
and Barton: The Role of’Msthodblogy in Classification in Psychiatry
and Psychopathology, PHS publication 1584, 1968; to the volume by
Gordon ClaridgezPersonality and Arousal, Oxford and London, Pergamon
Press, 1967, 274 pp.; and the reports by Mario Perez-Reyes in
Williams, Katz and Shield: Recent Adbanaes in the Psychobiology of
the Depressive Illnesses, DHEW publication 70-9053, 1972. It was
our impression that these reports supported our estimates regarding
the safety of the procedure.

I trust these date are helpful.

Good luck

in your studies.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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                    <text>,Mwywvw.

v.-&lt;wiw

v

May

Giacomo

d'Elia,

23, 1977

M.D.

Sahlgrenska sjukhuset
Goteborg, Sweden
Dear Giacomo,

to the question of the frequency of BCT
in the
is difficult to answer. We have no central reporting
registry and studies seem to be done on an ad hoc basis. The
best study is that of George Grosser which appeared in the
U. S.

The answer

Massachusetts Journal of Mental Health, 5:12~25, 1975. In that
he surveyed the changes in treatment in 1973-197“. I believe he
is doing anohher survey and you may wish to write to him: Dr.
George H. Grosser, Massachusetts Dept. of Mental Health, 190
Portland Street, Boston, Massachusetts 0211u.

recently completed a survey of the use of
in metropolitan New York and I enclose a copy of that report
We

ECT

have

for your interest.

other source would be the report of the
survey undertaken by the APA Task Force on Convulsive Therapy. The
survey was just completed a few weeks ago and the report is not yet
written. It should be available when you come to the U.S. You may
wish to write to Dr. Fred Frankel, Chairman, APA Task Force, 1700
Eighteenth Street, N.W., Washington, 9.C. 20009 to ask for an
The only

official

copy.

I trust these ideas are helpful. I understand that you
to the NIMH conference this fall, and I look forward to
seeing you at that time. Has there been any progress in your stuﬂy
of the effects of ACTH u—lo on the memory deficits in ECT ?

will

come

My

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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May

23, 1977

Alick Blithorn, M.D.
Royal Free Hospital
London, England
Dear Alick,

Irwin.

he

He

left;

Thank you

enjoyed his

for taking such care of

visits in

what more can I ask ?

my

associate, Peter

England and returned somewhat wiser than

I would be pleased to have you visit us here. I am
not in a position to set up a meeting, since these are ordinarily done
by the training staff. However, as soon as you know your schedule, I
would be pleased to recommend your invitation to them. As soon as
you have an appropriate time schedule, please let me know.

testing program
For many years I dedicated
the energies of the laboratory to program development and only recently
have I dedicated the work to the application of these methors, as they
are, to hlinical problems. I have an automatic negative reaction to any
suggestions that the present methods be changed, knowing that once I
travel down the technical road again, I will be lost for a number of
years, and faced with expenditures far beyong my capacity to bear. Say
Your

suggestion that

we

is interesting, but probably unfeasible.

automate our

reaction, but that is the present state. Most of my efforts
to applying the quantitative EEG methods to drug assay,
are
pharmacodynamic assessments, and clinical studies.
a phobic
it isdedicated

My

best regards.

I look forward to your

visit,

and

will

do what I can.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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17, 1976

William T. McKinney, M.D.
University of Wisconsin Medical School
Madison, Wisconsin
Dear Dr. McKinney,

I am pleased to write this
behalf of Oliver Nikolovski, H.D.

letter of

recommendation on

I have known him since 1967 (or 1968) when he joined my
staff at the New York Medical College as a staff research
psychiatrist. He was assigned to the out-patient department where
he has served since. He participated in a-aunboI-of clinical studies,
particularly evaluations of new psychoactive substances in the
treatment of the mentally ill. His work has ail-yr been exemplary) 44
e is a methodical, reliable, and careful worker. He is liked by
his patients and ie-ebte-to create a cheerful atmosphere with

his co-workers.

I relinquished the role as chief of the clinic, he
remained as therapist, and from time to time, participated in ”‘27‘~“§
Jay experimental studies. He has always been willing to assist in
studies and my co-workers have called upon him after I left the
College in 1972.
analmﬂWhe

-

has been unhappy at the College since
has not
he§2::;;ra
received the professional advancement that he
I would
recommend him for any clinical position similar to those which he
has held, and believe him qualified in clinical psychopharmaeoloé;¢?7?‘é‘ﬁ
and psychopathology. Unfortunately, I have not had the opportuni
to assess his teaching
as these are under the supervision of
others at the College,
“1&amp;5WWW/I.)
He

,//”

I trust these remarks are helpful.

.w'l/W

jﬂsdhobﬂg ,u,9'

3

Sincerely yours,
Pink, H.D.
Professor of Psychiatry

Max

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hw-

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a."

I v

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he...”

ww-uw-v-uwuwv—w—v-N"

' "' ""

“ '

‘

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‘

June 2, 1976

Merrill

T. Eaton, M.D.
Nebraska Psychiatric Institute
The University of Nebraska Medical Center
602 South 155th St.
Omaha, Nebraska 68106
Dear Dr. Eaton.

I am pleased to write this letter or recommendation on
behalf of Oliver Hikolovski, M.D.
I have

known him since 1967 (or 1968) when he
Joined my
York Medical College as a staff research
psychiatrist.
He was assigned to the
outopatient
department
where
he
has
served since.
He participated in clinical

staff at the

New

studies, particularly evaluations of new
psychoactive substances in the treatment
of the
work has been exemplary, as he is a methodical, mentally ill. His
and careful
worker. He is liked by his patients and creates reliable,
a
cheerful
atmosphere
with his ecoworkers.

I relinquished the role as chief of the clinic, he
therapist, and from time to time, participated in ongoing
experimental studies. He has always been willing to assist in studies
and my censorhers have called upon him after I left the College in 1972.
He has been unhappy at the College
since he has not received
fthe professionaly advancement that
he wished. I would recommend him
egfor.any clinical position similar to those vhich he has held, and believe
him qualified in clinical psychiatry and
Unfortunately,
.I have not had the opportunity to assess psychopathology.
his teaching ability as these
are under the supervision'of
-

p

When

remained as a

others at the College, such as Benjamin

Badock, M.D. and Alfred Freedman. M.D.

I trust these remarks are helpful.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

.vw-"a‘v

1w:

(pp

_

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James F. Buses, M.D.

Department of Psychiatry and
The

Human

Behavior

University of Mississippi Medical Center

2500 North

State Street

Jackson, Miss.

39216

Dear Dr. Buses,

I am pleased to write this letter of recommendation on
behalf of Oliver Nikolcvshi, M.D.
I have

staff at the

New

He was assigned
He participated

known him since 1967 (or 1968) when he Joined my
York medical College as a staff research psychiatrist.

to the out—patient department-where he has served since.
in clinical studies, particularly evaluations of new

psychhactive substances in thettreatment of the mentally ill. His work
is‘a methodical, reliable, and careful worker.
He is liked by his patients and crestte a cheerful atmosphere with
his

has been exemplary, as he
co~vorkers.

I relinquished the role as chilf of the clinic, he
realised as a therapist. and from time to time, participated in ongoing
experimental studies. He has always been willing to assist in studies
'and my co~vorkers have called upon him after I left the College in 1972.
When

has been unhappy at the College since he has not received
advancement that he wished. I would recommend him
[or any clinical position similar to those which he has held, and
believe him qualified in clinical psychiatry and psychopathology.
Unfbrtunately, I have not had the opportunity to assess his teaching
ability as this is under the supervision of others at the College,
such as Benjamin Sadock, M.D. and Alfred Freedman, M.D.
He

the professional

I trust these remarks are helpful.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

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V»: «v

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June H, 1976
Magda Campbell, M.D.

Department of Psychiatry
York Universiyy College of Medicine

New

550

New

First Avenue
York City 10016

Dear Magda,
Thank you very much for the prompy and helpful response
question regarding EST in children. I have also received
the latest survey by Laurette Bender which will be presented
to the Society of Biological Psychiatry it seems-— it is a
good review covering the most extensive experience in psychiatry
since it spans treatments to 1938.

to

my

In reviewing these data, I find myself in a dilemma.

.

«may

..
2'
.,
a
‘m

.

be done ?NThe APA Task Force on Convulsive THerapy will be faced with
a special problem in assessing these data.

n'”W-M.—y.,ur

in the

we can refer the issue to the appropriate group
of pediatric psychiatrists for their assessment.

Perhaps

APA

n.»....r,..—~,.—,,...

Again,

my

thanks for your assistance; and

my

regards.

"zv‘l—vv

Sincerely yours,
Wv,y-VYW"W“‘

Ia-‘u

axrzE-m-LY'

wwaszw

nan-v

n
w."

It

is clear that the data are mostly uncontrolled, and the evaluations
are principally global. No studies have made the detailed assessments
of neurological deficits or psychological changes follwoing EST
in children. Yet, as the Massachusetts survey in 1973 showed, EST
is given to children, usually over extended periods. What is to

Fink, M.D.
Professor of PSychiatry
Max

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                    <text>"'W—"“ V"

13',

"

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,

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June U, 1976

rs
~4-

~11,"

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mw—r-v

jwu

Laurette Bender,
M23

M.D.

Ben Oaks Drive West

Severna Park, Maryland 2llM6

u
.

‘1r-Zt‘mur

Dear Dr. Bender,
Thank you very much

.v—q

~n-m-w-y.

~wvmﬂ'mww‘1'm-

recent report,"Childhood

for the opportunity to read your

and Adolescent Remissions in Adult

Adjustment in Shock Treated Schizophrenic Patients". It is
clear from this survey that the administration of either metrazole

or electrical seizure therapy did little harm to the subjects, and
perhaps assisted the short term adjustment.

Excepting your studies, we have been unable to find
other adequate examples of treatment in children; yet, the
practice seems widespread, as was demonstrated in the Massachusetts
review of EST in that state in 1973. What is to be done 7 Should
additional studies, of the effect of EST in childhood schizophrenia,
be encouraged ? Should the studies be comparisons with drug therapy
alone, or should there be drug and other therapies as comparison groups

many

a

I fear that the APA Task Force will have a knotty problem
in attempting to place EST in childhood schizophrenia in proper
perspective. On behalf of the Task Force, I thank you for the
chance to read your reports. I trust I may share the draft sent
me with the others on the project.

P.

mm

'wv-Wmm

My

best regards.
Sincerely yours,

unsung-weep

.u-Aww—v-

«wr-

W"'l&lt;:m‘&lt;a"'—wiwr

Fwnnm‘v'

A,

Fink, M.D.
Professor of Psychiatry
Max

?

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                    <text>June 9. 1976

Juliq‘v¢:;dlewicx,

M‘D.

Institut De Psychiatric

Hopitul Uhiversitaira Brugmann
h, Place Van~Gohuchten
Bruxelles 1020 (Belgium)
Dear

of

Juliell
Enclosed,

after

much

delay, is our draft reyort, "Effects

EEG and Memory Function in
0 (Org OIuGS) on Quantitative
Normal
e Vblunteers" fur Inna consideration for publication in
Heurozgxchobiologz. ‘I ragrot the dnlaya, but as yuu V111 see, the
analynes have-been most difficult and interesting.
ACTH

You should also-receive parallel reports from Dr. Rhea
Dornbush and Dr. Judith Rapaport. Both have studied ACTHh-lo and
have acmething to any at this time.
My

regards.

—

I
‘-.-v

Sincerely yours,

gigmrvc'rx

'\.‘.

Fink. M.D.
Professor of Psychiatyr

Max

upma~ﬂwwswrwug

50—th

'w-

3'.

‘mygq‘ﬁgpﬂﬂw

w:

gig—m;

{—55—

.41“

we

cc:

W.

Bannita,

M.D.

�</text>
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June 15, 1976

Judith Rapaport, M.D.
Department of Pediatrics

Georgetown University Hospital

Washington, D.C. 20007
Dear Judy,

have read your report with interest, and some
on to
sorrow that the results were not more positive. I have sent
We
should
hear from
Dr. Menditwicz and the Journal Neuropsychobiology.
him shortly.

I

it

‘

Henk will be coming to see you Thursday. Please excuse
I hope that I
as I shall be busy with my daughter's graduation.
'
will be able to cash in a rain—check shortly.
me

v

I'mwr.

My

regards.

W‘s-W1

rr

-mz-..-v-v—-

Sincerely yours,

'0.‘l:-'rmm

,1”

AV

«um-M.

.
«wry

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ku—ry-

run.“

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wwa.m~,-uwwuu.;-

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131.27?

my:

an:

Professor of Psychiatry

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                    <text>gamma.

.

K‘w- ,,

a... 'o‘xw'.
»

Vﬂ'ﬁ-WW'M
~-.-.~lc‘vn-m‘mnwrm“'-vrw-'Q‘éem‘vﬁmvvew“m

.n«.,.,m,~.—v—w-n_~

V

,

vain“.

may...

.,.,...i

,V“

:.

Julien Mendiewicz, M.D.
Institut De Psychiatric
Hopital Universitaire Brugmenn

up—m m7.y,.......,.,....,.,..r..‘.0-

“mg. .,

,

Viv-wr'm'rlcaﬁ—

wry--5. ”yew.

-Myy..y.v.-73“, 1-»,

June 15, 1976

h, Place Van Gehuchten
Bruxelles 1020, Belgium

Dear

Julien,
is a draft report,

5-10 (Org 01-63):
Cognitive and Behavioral Effects in Hyperactive, Learning Disabled
Children", submitted by Dr. Judith Rapaport for your consideration
for publication in Neuropsychobiology. This report complements the
study submitted last week from my laboratory on the effects of this
compound in normal male volunteers.
Enclosed

"ACTH

Dr. Rapaport has used the same materials and has
worked from the same hypotheses that we did. As I indicated in my
letter, I hepe that you may be able to condider these reports together.
My

regards.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

,

e ..

..,

w...“

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7.7—

.

V

.

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                    <text>rv"n'rrmw—uv&lt;

..—

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1

,

M

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Harm.

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w"

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- mm...“:r»—q——-"/~-m~vv—\T~~wv|Wuwm'w- r»,

.-

.....__ 71-12

June 30, 1976
Dear Don,
We

have done one pharmacodynamic study of bromazepam. The

report is enclosed.

these data, bromazepam is hardly distinguishable from
to the amount found in the blood when the EEG effects
are the same as those of diazepam, i.e., we thought bromazepam a more
active agent in the brain (high EEG levels) with lower bbood levels.
Schwartz and Conney of Hoffmann—La Roche suggested that the sensitivity
of the methods was such that there may be an error in the bromazepam
blood levels, and that this finding was possibly an artefact.
From

diazepam except as

The manufacturer is Hoffmann—La Roche;
Bookman (212 695 1400, x3772).

Dr.

Philip

any

clinical experience with the

the contact is

I cannot answer the clinical question as

My

compound.

regards.
Sincerely yours,
Max

Fink,

M.D.

we

have not had

(“Wm-w.

4

‘»

puwwmm—

�</text>
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                    <text>.
.

..

A.

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,

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a... warm-u &gt;Vrvvwr—
.

Jane 30, 1976
Raoul Desjardins, M.D.

RD

Associates

Mendham, New

.

.

.

Jersey

Dear Raoul,

..,

7.3.7.

”w

.L

.vv,

w

up...

Thank you for recommending Dr. Young-ll R0. At the
present time, I have no opening for a psychiatrist and I regret it,
since his credentials are impressive. I shall keep the record at

hand, should the

situation change.

e...

._—Vwm‘".l,.ﬂ.wwm—,.va

Dr. Feet of Organon is en route to the CINP in Quebec
and I have arranged fun him to visit my laboratory and Mercy
Hospital on Friday.
Your comment about Neil Burch is interesting. If he
undertakes a clinical evaluation study, I believe it will be his

first as he has always found such projects uninteresting. He does
have a long record of interest in EEG quantification (it was
from him that I obtained my first period analysis program in 1963)
but his principal interest has been in the electronics and engineering
of the problem, not its application. Only lately, in a single syudy
of cocaine, does he seem to assess the relation between EEG and behavior
after psychoactive drugs.

to DH-52u ? I have been asked whether
we have undertaken clinical studies and I answered in the negative.
you tell me that someone was doing clinical studies ?
Whatever happened

celebration.

My

regards,

and best wished

for a

Did

happy 200th birthday

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

WWW-WW?”

m
w--:

WW1“?!

‘As

�</text>
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                    <text>¢.-—u-.-,—_sau~.

mew—

Vx~"

:w'n

ww‘nwnzz‘mnwmrrnz-mmwv.-

_

.

'

_

mm

-

~

'

.

[cwxyw.\'uV

F

A

vu-wn-W—r

“mil-mm

July 3, 1976
Dr. Simon Sanchez, M.D.
129 Asharoken Avenue
Northport, N.Y. 11768
Dear Dr. Sanchez,

I have read your letter of June

29 and your C.V.

with

interest. I regret that I cannot personally attest to your ability

as an electroencephalographer, as the recommendation
American BEG Society requires.

to the

I note that you have had experience with Dre. Abrams, Su and
that they should be able to attest to your
abilities, for surely Drs. Abrams and Su, well trained and modest
men that they are, have complied with the requirements of the American
EEG Society at some time in their lengthy training periods.
Rosen. I am confident

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

'n-wwv”.vrmnw—n,

wn—u'lr-m

�</text>
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July 3, 1975
Mrs, Margaret Henry, Secretary
American EEG Society
4137 Erie Street
Willoughby, Ohio #4094
Dear Margaret,

I have been asked by one of the resident trainees at
our University, Dr. Simon Sanchez, to write a letter of recommendation
on his behalf to the Society.
I am embarrassed by the request, as I am unable to attest
to either his training ror his ability in EEG. He did not attend my
seminars, nor has he workéd in my laboratory. He has worked with one
of my students, Dr. Abrams, who has never participated in a well
defined training program in EEG. I do not know the ability of Dr. Su.

that

For

he obtain

My

this reason, I

letters

from

written.to Dr. Sanchez suggesting
his immediate supervisors.
have

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

,

a" _

�</text>
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                    <text>..

-.:_.m-Wwwwm...wa

1w

.,

wq'rt-‘k

y~‘-ﬂm‘m§r"ﬁr'x-mg... .q‘, "—37.

V. .

.

pun“...

v.7—

,.._

—-.,r

. ~x-

aura:

”a".

...,.

w unv) Ide:r-n~1"" W‘Wu“. 1—"

““!Y.~“"v

caviar

-

.~

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- aw:

—. .

WV,

”m.- _._

.‘wr ..- -

.vn

.

..

July 12, 1976
Robert S. Wallerstein,

M.D.

University of California, San Francisco
San Francisco, California 9u1u3
Dear Dr.

Ref: Reese T. Jones,

Wallerstein,

It is

with Reese Jones,

M.D.

this evaluation of my association
of
occasion
his consideration for promotion.
the

a pleasure to submit
on

first

met Reese during the early days of research into
reseaarhers had to struggle to get permits to have
marijuana,
and
cannabis
supplies were available only from the illicit markets.
Reese carried out some innovatihe studies and freely shared his findings
and experiences with us at the New York Medical College. Later, as he
developed the long term studies, we were able to share our experiences
in Greece with him, and to learn from his observations regarding
tolerance. Concurrently, his interest in electrophysiology brought us
to some common meetings and I have heard his presentations with interest.

I

when

In these experiences, I have found him to be an earnest,
thorough, and sophisticated worker, and an unbiased observer. On one
occasion, in his presentation to the American Psychopathological Association, I was on the committee that unanimously awarded him our

first

Morton Prince Award

for excellence in presentation.

initial opinions that he was a
work
and
continues to be innovative,
his
bright young researcher,
His
presentations at the recent conference
well controlled, and systematic.
and his discussions were excellent.
done
on chronic cannabis use were well
He

has sustained the

I cannot evaluate his teaching ability directly, as I have
On these occasions, his presentations

only seen him at national meetings.
have been lucid and logical.

It is

a pleasure to recommend him for promotion. Recently,
I submitted his name with my recommendation for his consideration as
a paincipal scientist at the newly formed Long Island Research Institute.

“AP.

-wrr~vrn—»vr

M"

I

trust these

comments

are helpful.
Sincerely yours,

w-nxmyw-muw-nww:

xv-

wwwrv-(wJ—py—

-

Max

Fink,

M.D.

Professor of_Psychiatry

�</text>
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                    <text>‘11“? 1—«27..:-.~m-w-.-w,-

“a

m. win-w.

'w;

sv‘~x.v:vv‘§12‘-,Wg(Furs x'nm.-..‘_-.'vvﬁﬁ—u-Uvmwwyv-r’utugiv‘wy

m...

we m q... .5

1,, n u-quwﬁ-ylwzi..\lz4 , ”my“.

a“. warnin.

,....._. ..

w.“

—~.~

,—- ,

pun

~-.‘ a~ ~wv-»~n-w—~

”N.“

n.

,

mrJr—lvvh‘lw‘dvfwmw‘mw-h

July 13, 1976

w.

merma-n-sm

Julian

Mendlewicz, M.D.
3-1020 Brussels, Belgium
Dear

Julien,

1-.»

It

am.—

v-a'vw-vq-m

v
"Iva-1

("r

m.

7....

v.1...

the meetings as

was nice meeting you
much as I did.

in Quebec. I hope you enjoyed

On my return, I found the letter of acceptance of the
Rapaport paper. I called her, and she has agreed to send you a shorter
title and a corrected, clear version of the tables.

mum.

Fw-wvr-‘ar

up”...

Dr. Dornbush has agreed to send you a

of the effects of

ACTH”010

in elderly subjects.

draft of her report

I have reviewed the manuscript and made a few corrections
which I believe improve the draft. Please substitute this draft for
the one in your hands. This one is marked (VI:7-8—76).
Memory"

title

of
is acceptable; as is the
The

shorter

Thank you
My

" ACTH

list

,

Quantitative

oi'hgy words.

EEG

for your consideration.

best regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry
Max

and

»

..

.._,7

..

.-

5

WWW”

�</text>
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                    <text>rvvt—U‘m-z-"w~.-; \

wx—y. ,-

ma «may, we uwtv mm: D, ."wvlu , ‘--.4.&lt;w,w.q..-wu«.¢\~. .wo-uapm m.)- Avid-'nxuw.’"—9,. I'w'.‘
-

my V11 ~»y

yum\ 3'”m y—m .w “my“... man a...“"jumpy.
».

nu,-,..w...ry~.u.wm.yv(u~——~—my

mar—“munww

.

.e

(v

y

-,

7:7,.»

,.

September 16, 1976
Mr.

Philip

G.

Sunderland

1908 Sunderland

Washington, D.C.

fiace

20036

Dear Mr. Sunderland,

material that you requested in your letter of September
13, 1976 will require some work-- to summarize the reports and select the
references. We would be glad to undertake such a review at the rate of
$lOO/hour, with an estimate of $0 hours for one that may meet your needs.
I trust that this will be acceptable.
The

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

~~( «rc‘ a.

..

'1'

�</text>
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                    <text>August 2a, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives of General Psychiatry
Chicago, Illinois
Dear Dan,
On my

return

Re:

M8

##024

from my holidays, I found your

letter of

26 with the critiques of the paper”Effioacy and Shfsty of‘lhduoed
seizures (EST) in Man? I cannot say that I am surprised, for I have
become accustomed to unusually sharp criticism of any report that I
write on EST. But I did find many of the comments useful, and taken in
the spirit of improving the product, I shall try to correct some of

July

the omissions and the errors, as well as add a section of clear critique
of the status of our present knowledge. I do think that the last request
is for an additional paper, but perhaps the addition will not be too

large

WW“?

v

.1.-r.y"-',-¢v

-_—

pwqwm'w

«serum-man“.

-~‘I:

"a,

wuwr‘

“In."-

7.,

and may be

useful.

In your letter you indicate that "I have decided my initial
reaction is off target - I enclose a letter I wrote; I also enclose Noch

Callaway's response." Neither your letter nor Noch's response were in
the package, and if you still think these would be useful in re-writing
this report, I would be grateful to see them. (I received critiques I to V).
I have some specific questions for reviewer # 2 (begins 'I
appreciate the timeliness of this review, esp. . . . '). He argues that
the issue of the comparative efficacy and safety of EST vs. antipsychotic
and antidepressant drugs is not dealt with till at all. I thought that
I have cited the principal articles in this regard; would it be possible
to ask whether there are other citations missing? If the criticism is
that the presentation is poor, then I accept that criticism and will
re-qrite it; but I do believe I have cited the most relevant articles.
I also find his statement 'there are hints of the possibly overly
sanguine clinician—enthusiast in some parts' helpful, and have attempted
to take a more judicious posture.

this

In any case, it will take a few weeks of extra-effort, but
means a delay to get the text back to you-- probably early October.
My

thanks go your

My

regards.

to write such fine critiques.
I

.m

many busy

researchers

Sincerely yours,

r-m—vm-v

’..1w:'

who

Max

Fink,

M.D.

took the

effort

�</text>
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                    <text>'w-WAa-MW‘WWJ

11".

"'v“"'-‘,‘-:&lt;--r'uwrvr .uwu—quuwwy-owwmmwJ'Unwv

mu

m

7‘" mu,«a. ..

r. rum-n- ..

-

nu.

sup... «my.. a....

Wm.

r:mnur'm-mm‘n.w.&gt;

,.

.._... w. 4--

wwmmwn-m'

WWW“ ’- l...

August 11, 1976
Dr.

J.

Fishman

Montegiore Hospital
Bronx, New York
Dear Dr. Fishman,

I have just read your article in Pharmacology describing
progress with the long acting formulation of naloxone, and I congratulate
you on the progress which you have made. It is heartening to read that
the possibility is ever so much greater that an implant will be
possible for treatment in man. The hopes and vision of the late 1960's
regarding the treatment of opiate dependence wane obscured by the
political events of the period and the drive for methodonization of
the nation.
While I

no longer involved in the testing of narcotic
hear a relationship to the study unit at the
New York Medical College. I am confident that Dr. Richard Resnick and
Dr. Alfred Freedman would both be interested in cooperating in human
trials as soonn as the preparations are tested for toxicity.

antagonists, I

still

Again,

am

my

congratulations.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

v‘w-V‘M‘rl‘w‘rp‘

. Irv.

-

"w'w‘l’

�</text>
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                    <text>4-4 - v-r-.—-

... we»

yrs

~

',w":»“ xv»-

2‘

an" «nary-w

umwﬁﬂmwxmmn:

'
V
av. we-mxn-p.»...

m

,

.

'

_

,,

.

,

.

turr-

mun- we— ,7

,

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a“,
a«ww—nvv~;.~~w-W»-wmqgm.

"
'-

-

W'v.ﬁr—"~Vwﬂn‘l&lt;mﬂw“

August 11, 1976

Alfred

New
New

M.

Freedman, M.D.

York Medical College

York City

Dear Al,

I have just read the report by J. Fishman, "Preparation
and Evaluation of a Sustained Naloxone Delivery System in Rats" which
appeared in the journal Pharmacology 13:513~519, 1975. It is excellent
and suggests that a long acting formulation of naloxone is feasible.

I

commend

the

article to

you.

have sold the house in Setauket and returned from a
trip through Great Britain (for a nation with such beautiful
countryside and and exciting heritage, why can they not learn to
cook food tastefully ? ?).
We're busy with college preparations for
the last of my children and anticipate with some optimism the next year
We

long

at

SUNY.

My

regards to Marcia and Irv.
Sincerely yours,
Max

Fink,

M.D.

-,,1-

1w“.—

�</text>
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v

.

vv‘V/Wﬁﬂ'

uv-w WV .- n

IXWIruwlnuwm-w-wg

rump-“WM w—u- "tA-Wrmﬁ‘wlﬂuA'mmimw.~-v..n-—u‘..._..,-u

_,,.

.mttmmvwvw .m-wv..-“

August 11, 1976

Paul Blachly,

M.D.

University of Oregon

Portlan,

V

ﬁnnr‘.

,—~;~.~wmwvz

1......

www.—

ear—w

Oregon

Dear Paul,

I want to congratulate you on a fine issue in the latest
I note on my return from my holidays that a number of
readers have taken your advice and written for preprints of my articles.
(Incidentally, the one on cost/benefit was sent to Dan Freedman. He sent
it to 5 editors, and each chewed the report over like it was a
favorite bone-- criticizing the length (too short and too long); critic—
izing the inclusion of schizophrenia (EST is not a treatment, only a
sedative); criticizing the language (too loose, needs tightening); etc.)
(#3) of

GTE.

s
n

arm

——r-ww,vn

vr'wawlr-er'

W

writing with regard to the announcement of a course
I would so like to cooperate and participate but the dates you
suggest are those that conflict with the APA Divisional meetings in
New York where I am scheduled to give a report on EST. If it is still
possible to change the dates, perhaps the next week-end ? Indeed any
week-end thereafter in November will find me in California.
on EST.

I

am

WWW

"Wv

"am-w:

sure you have written to the APA NEWS-sad the announcement to
I believe. I would also send it
Med
Sabshin asking his intervention for its publication in
directly to
the newspaper. Otherwise it will get lost on page 35 or so.
In addition, I

am

Mr. Robinson,

My
erme—rqqu—u

regards and agaén

my

congratulations.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

P.S. This

letter is not for quotation, please.

m- :rwwuv-uw

_,_, ,

�</text>
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                    <text>John

M.

Davis,

SepteMber 2h, 1976

M.D.

’

Illinois State Psychiatric Institute
1601 W. Taylor Street
Chicago, Illiniois 60612
Dear John,

involved in a cost/benefit analysis of EST. The
draft that I submitted to the Archives was returned with many good
suggestions for improvement. Among the comments was a suggestion that
I include a table of the comparison studies of EST and drug therapy,
in a fashion similar to the reviews that you and Jon Cole have in~
cluded in your many evaluation: of drug therapies. In checking
the latest edition of F a K, I find that you and Jon have included
EST in your 'Summary of Controlled Double Blind Evaluations of the
Antidepressant Drugs', vol II, page l9h3.

I

am

if

I could obtain the citations
which you considered acceptable for this revieWb- those reports that
you included in the 7 studies greater than placebo, 1 equal toMy
placebo: h greater than imipramine and 3 equal to imipramine.
own records include many more studies , suggesting that my criteria
of acceptability are less stringent than yours.
for each

It

would be

Is

it
7

column

Many

helpful

possible to indicate
thanks.

which papers were assessed

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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              <elementText elementTextId="61553">
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                    <text>rag—ur—

‘m

7-”

‘Ww‘”WW"""".NW1w4-v'7wawair-1

—-v.-vxww:r

J,

mmmv

.._._..

~

VT‘FI'“

wuamv"mm“meW'erw "N-Wﬂmwmﬂmm—mm".wv

--

wwwrurnwvw,

vuw

“a,”

q.._,..”

Septquber 2h. 1976

Julian Hondelewicz, M.D.
Institux do Psychiatric
Hospital Untversitaire Brugmann
h, Place

81020
Dear

Van Gehuohten

Brussells.

Belgium

Julian.

associates have been over our paper on ”EEG and
Tank Performance after ACTH h-lo in Man” with great persistence and
have found some sentences that did not reflect their point of View.
_

My

this draft, an&amp; if the paper
is not yet in gallqy, I.vou1d ask that this copy replace the one that

These corrections-hawe been maﬁa in

you have in your hands. I think
improving the galley.

it

would be

less expensive than

,

I tfust this is in time.
many

thanks.

Sincerely'yours,
Max

Erik,

M.D.

Prorbssor of PSychiutry

5...", ‘ wﬂw.

�</text>
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                  <elementText elementTextId="103974">
                    <text>October 7, 1976
Dear Peter and Vi,
The enclosed pictures reminded me of the many pleasant
hours we spent in London. I think that Rachel has captured some of
the enthusiasm of the children, and I hope that the pictures give you

as

much

pleasure as they gave
After

we

of roads, places to

left

me.

London, we were very lucky in our choice
and of course the weather. We

visit, hotels

enjoyed England and Scotland so much that

we cancelled our trip to
additional week in south-west England, travelling
to Tintagel to follow the history of Arthur. While we in the 0.8.
celebrated our 200 years, in our English travels we were brought
face to face with the thousand years of history. It was a good
time for all of us.

Italy

and spent an

tried to get back to work and
visited last week and we discussed
some trials of Intel in psychiatric states. I have broached the
subject to some of my colleagues, and am faced with one of two
reactions-- "Nonsense; it can't work" or " Well, nothing else seems
Since returning, I have

have succeeded only

lately.

Derek

to work well, so why not". From the later respondents I hope to be
able to put together a few studies in hyperkinetic children first; and
bipolar depressives second. Derek seems well and spoke of how he is
enjoying the work. But organization work has some difficulties, which
only became apparent when we had to decide on the actual procedures
to follow. About Gerdaxyl, we could come to no conclusion. I suggested
that clinical trials could be done in this country, but I was sure that
you could do as well in your clinic as anyone I know here.

is quite empty now; all three children are
at college and Martha and I have the evenings to ourselves. Some
of our energy is going into fixing up the house and garden, and we
Our house

away

go out for meals more often than we have for many years; but
most part we seem to be adjusting to the 'empty nest' syndrome.
Of course, the children are coming home for the holidays next month,
so it is not as 'empty' as it may seem.

to
for the

seem

still

Give our regards to the children. I
want to come
visit your clinic. If Derek keeps his promise (and I believe he
will) I should be back in England in late winter or early spring, and
and

should like to drive out to Oxfordshire.
My

very best-- I hope the house
As

is all

ever,

you expected.

�</text>
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                    <text>October 11. 1976
Docent

H—1021

Peter Hales:

Hungary

Budapest

Dear Dr. Halaaz.

for your 1nqtiry. I regret that I do not
this laboratory at this time, but will keep your
file for reference, should an opening appear.

Thank you

’

have a pos1t1on in

npplication

on

You may wish to write to Dr. Jan Vblawka who is
gF'
3Q the Missouri Institute of
(5hoo Arsenal
~

now

Psychiatry
Street, St. Louis,
H1asonr1 63139) or Dr. M1chael Taylor (Professor and Chairman, Dyyartment
bf Psychiatry, Chicago medical School, VA Hospital,Ch1cago, Illinois),
[’both of whom are Innded for additional positions at this time.

i‘L

j

,

=

Sincerely yours.

,

Fink, 14.1).
Psychiatry
Progessorfof
:7
/” ,_._

Max

l
,

,

‘j’
'

.

1:”

�</text>
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                    <text>u
”w"...

Nmrv&lt;m-

—

,

«Ml-.7.

,nt'n'r-n-I'

Wm»...

,

K". e...“mmmm‘n'w“"lvn"‘l’?ﬁ‘.'mm'w

.7

October 18, 1976
Herman van

Praag,

M.D.

Dept. Biological Psychiatry

Psychiatric University Clinic
Groningen, Holland
Dear Herman,

I have received your latest annual report, and I thank
for the opportunity to gain some insight into the new developments
in biological psychiatry. The extent of the program is impressive, and
when I add the time you must spend visiting and lecturing around the
world, it is even more interesting to see the extent of the accomplishyou

ments.

it that

Rumor has
? Can ue

Is that correct

ﬁerusalem in the future
Again,

my

?

you

will

expect the

be or are already in

same

Israel.

enthusiastic programs

thanks for your report, and

my

from

best regards.

Sincerely yours,
Max Pink, M.D.
Professor of Psychiatry

.MWW

�</text>
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"Grovvrzwywurrw-“v

“A

mew...

mum

mu» m... ‘vW.--T-.-xttvw

In}

October 28, 1976

Hrair
New

M.

Babikian,

M.D.

York Medical College

Westchester County Medical Center
Valhalla, Now York 10595
Dear Dr. Babikian,
Thank you for your kind invitation to participate in the
series of lectures on Drug Abuse. I regret that it wéuld be a difficult
responsibility for me to attempt to present the data on drug abuse
at this time. Since leaving the New York Medical College, I have
turned my attention to other interests and I have no personal
acquaintance with the latest developments in narcotic antagonists
or cannabis-- two subjects that were my interest when I was at the

College.

I am confident that Dr. Resnick, who has sustained the program,
will be able to present the latest information on the antagonists.
Should you wish to include a review of cannabis, I suggest you call
on Dr. Rhea Dnrnbush (now at the Reproductive Biology Research Fdn,
#910 Forest Park, St Louis, Mo.) who is editing two volumes on
cannabis summarizing our studies as well as a conference which she
chaired in January. A third candidate would be Dr. Arthur Zaks.
Arthur has developed one of the most active of the methadone treatment
programs in the city. He has continued his research interest in
carrying ourtstudies of levomethadyl in his practice. He can be
reached at Flushing Queens Medical Associates, 136—80 Roosevelt Avenue,
Flushing 11354.

for

I trust these suggestions provide an adequate replacement
in the future, be interested in presenting a
on convulsive therapy, I would be glad to do what I can to

me. Should you,

program

assist.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>vmv,1-r&lt;.«
r.

.,

.

.

,,v._ ..

,. -..

,

,.

'“vr'm. .... 7:“.

-W a:

f‘FV'vﬂYﬂ

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“w"w’WWWrrwﬂv-awnvwvmwlwx-

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NF.

9......“

..,-.

-Ww.mmwm-

..

I-‘-"r'*'&gt;—L‘-:\-'Wr~

A

i

-

mew

October 11, 1976

Morris Lipton, M.D., Ph.D.
University of North Carolina
Chapel Hill, North Carolina
Dear Norrie,

I am working on a project involving dietary factors in
hyperkinesis; In talking to Judith Rapoport, she told me that you had
chaired a committee review of the Feingold and other hyptheses for the

Nutrition Foundation.

we

...

my

a copy

w-n-»L;-.-wvm7.w~mw‘nw,.,

ACNP

?

Is the report published
Thank you

If not, is it possible to obtain

?

for your advice.

Now

that the chores for the

are over, perhaps you can get back to more
My

self satisfying

regards.

W'HV

yaw-aw,

Sincerely yours,

1ym"m.

urn-m

«mummy:

Ww'l

(mum—r

.

v:

immannxrxnwmcvwn

:«r

Wm.

r-

.

‘Nn-nnam"qu-':v'l

.1

,

..

.‘qm‘ar-ww-n

Jaw"

Fink, M.D.
Professor of Psychiatry

Max

work.

�</text>
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54

i

.

m.mar-m

w—ouV-ww-v-w-WVu-v'vw

2~

:v.

~

mmwmwwxmmmwumw"mrwwﬂnmnh

.

,

V.

,— ,

“7

—..

.V, mi N...

I

...

...

,
.

"W.

...

N.

....._,,..~.m.,...,..u...w...,_n...

i
E

-

October 29, 1976
William J. Darby,

M.D.

President, Nutrition Foundation
#89 Fifth Avenue
New York

City

10017

r".

nnwyv-wvrm.-

Dear Dr. Darby,
We

have become

interested in testing

some new compounds

in the alleviation of the syndrome of hyperkinesis in children.
Our interest is in the possibility of blocking a central allergic
response to food additives as allergens. We wrote to Dr. M. Lipton
for some help in the report which he chaired on behalf of the
Foundation.

has referred us to you for a copy of the reports of
the Nutrition Foundation regarding the possible role of dietary
He

factors in hyperkinesis. I would
reports that may be available.
Many

be

grateful for copies of

thanks.
Sincerely yours,
Max

Fink,

M.D.

Professor-of Psychiatry

any

recent

,

,,

,

�</text>
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7m.

,7
v

x
.

.z-mwmnm

m

November 5, 1976

Daniel X. Freedman, M.D.
Chief Editor
Archives General Psychiatry
950

East

Chicago,

59

Street

Illinois

60637

Re: Ms.

#QORM

(Revised)

Dear Dan,

Enclosed are two draft copies of the revised version of
"Efficacy and Safety of Induced Seizures (EST) in Man". The draft
reflects an extensive revision and my attempt to answer the inquiries
and suggestions of the reviewers of the

earlier draft.

I trust this approach is useful to the profession.
My

regards.
Sincerely yours,
Pink, M.D.
Professor of Psychiatry

Max

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November

William Zung,

.—

.

2a, 1976

M.D.

Duke University Medical Center
Durham, North Carolina

Dear

Bill,
programs is quite extensive, being the
13
than
more
years effort. It is not possible to duplicate
and the documentation without an extensive effort which
Our

product of
the

files

library of

justified by your letter.
If there is a specific problem or program which may be of
know what the question is and the capacity of your
me
help, let
machine, its configuration and characteristics, I will be glad to
send you what is needed.if we have it.
does not seem

Good

luck.
Sincerely yours,
Fink, H.D.
Professor of PSychiatry

Max

&lt;;‘:"r —r\.‘v

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w

~an ---—~—-mv.»_ "1.ku

v.-»;....w-~

1‘

ﬁZV'I‘WI'ra-ﬁp-aruw,-n-r;vo‘~;nxx’wwrnzrnw'Wnn—wv

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7.

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.

.,nnm~.1.-.w~.-wmw.mr

November 25, 1976

Dr. David Avery, M.D.
VAH—

Palo Alto

California

94305

Dear Dr. Avery,
Than you for sending me the preprint of your report,
"Electroshock: A Lifesaving Treatment Shrouded in Myth". It is
well written, and makes good points in the issues that have
confused the public. I am not sanguine that Psychology Today will
publish it, but perhaps their editors are less biased than I

think.

I am impressed by the figures that are included. I
presume these come from the manuscript on the efficacy of ECT and
antidepressants. The figures should have the actual articles cited
from which the data are derived. If these are not from that article,
rather than
then they should be prepared for the psychiatric press
‘
the public press.

I could not find citation 36: it seems to be in error.
of the others are incomplete, but completeness is not necessary
for the lay journal.

Some

Let me also congratulate you on the fine review that
has recently appeared in the Archives. The analysis of deaths with

EST and antidepressants
of my reports in press.

is

most

useful

and

is already cited in

two

I do hope that you will continue yuur interest in EST. The
Task Force on Convulsive Therapy has been reviewing the evidence for
safety and efficacy of EST, and we have found a number of problems for
which the evidence is lacking. It would be good to have another unit
carrying out the kind of careful studies of EST suggested by these
reports. If you come East on a visit, come and visit us at Stony Brook.
We are developing a study team for EST research and we would enjoy
APA

meeting you.

My

your other

please send

thanks for the opportunity to read the report and for
efforts. When the antidepressant review is available,

good
me

a copy.

My

regards.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

Xt

School of Medicine

W

[DcpnrnncntofPsychhuryznuiBchuvknulScmncc
PSYChOPhilrnmaﬂogﬁ’

[laboratory

-

EEG

‘

1

Re:

To Whom

It

May

Stony Brook, N. Y. I794
Phonc:5]6444—2447

John Kramer, M.D.

Associate Professor
University of California - Irvine

Concern:

I have known Dr. John Kramer for many years—~as a friend,
student, co—worker, fellow scientist and fellow teacher. From 1958
to 1962, he was a member of my staff in the Department of Experimental
Psychiatry at Hillside Hospital. When I moved to St. Louis, I invited him to join me and was keenly disappointed that he decided to
move to the Far West.
Since then, I have followed his career as
administrator
in SAODAP, and most recently, at his
as
researcher,
week
I
a
spent
as
invitation,
visiting teacher at Irvine.

teacher.

John

He

is

a dedicated,

resourceful, serious researcher

and

has approached the problems of drug dependence from the

innovative point of view of social history.

His writings on the

roots

of our present dilemma in opiate and cocaine use are outstanding. He
has carefully distilled centuries of history and has written excellent
reports on heroin use and treatment which are important to the present
dialogues gh.heroin maintenance.
In his experimental work, his studies on antidepressants
remain as important contributions to a rapidly developing field.
In his teaching sgssions, I have found him to be liked by the

students, responsive,

courages discussion.

I have

no

and through.
A

hesitation in

He

presents ideas fairly,

recommending

Fink, M.D.
Professor of Psychiatry

Mszg

en—

John Kramer for promotion.

Sincerely yours,
Max

and

�</text>
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                    <text>STATE UNIVERSITY

or

N‘r’iW

Health Sciences Center

YORK AT
-

srorw

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology
Isaboratory

—

EEG

Stony Brook, N. Y. 11794
Phone: 516444-2447

December 2, 1976

Samuel B. Guze, M.D.
Spencer T. Olin Professor and

of the Department of Psychiatry
Barnes and Renard Hospitals
Washington University
School of Medicine
Head

h9h0 Audubon Avenue

St. Louis, Missouri 63110
Dear Sam:

Enclosed are some reprints you requested. The thesis
and behavior has been tested best with antipsychotic
of
drugs. It is Still an idea with thymoleptics. The best
report is the diethazine study (1958). The clearest pre—
EEG

diction of antidepressant activity is cyclazoeine
and recently, the studies of mianserin by Itil.
My

(1969)

regards.
Sincerely yours,
Max

MF:fg

encls.

Fink,

M.D.

�</text>
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                    <text>W
X:

STATE UNIVERSITY OF NEW YORKVAT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

‘

EEG

Laboratory

Stony Brook, N. Y. 11794
Phone: 516-444-2447

'
.

December 2, 1976‘

Jon F. Heiser, M.D.
Asst. Adjunct Professor and
Asst. Chief, Adult Inpatient
University of California

&amp;

Emergency

Psychiatric Service

Medical Center
101 City Drive South
Orange, California 92668
Dear Jon:

While I am sanguine about my ability to identify projects
and issues which are currently of national significance, I am sorry if I

suggested that I could predict the behavior of national funding committees.

Such committees are now made up of representatives of the laity and
minority groups and no longer need be the best in our society, nor the
most rational. Hence, my hesitation in even suggesting that I (or any—
one) could predict their behavior, which often is formed by such issues
as geography, color, "old—boy syndrome", etc.

If you ask whether there are target issues of high
which should be fundable, try the following.
1)

patient to

How

can one

(a)
(b)
(c )

predict the responsive

priority

from non—responsive

antidepressants

lithium
EST

(How

to predict the end point of

EST)

to drug therapy? To
treated differently than men by psychiatrists? Are the distinctions justified by biology? If yes, by what biological differences?
EST?

Are women

2)

Do women

3)

What
What

respond differently than

is the efficacy

men

and safety of

MAOI?

In what conditions

is their relative merit against other treatments?
are these useful?
there any truth in the legendary statements of toxicity of MAOI?
.

(5

Is

any clues to a genotypic diagnosis (clafhfication)
system? For example, under what conditions does the sedative'threshold pre0
dict course and therapeutic result?
h)

Are

there

�Dr. Jon F. Heiser

December 2, 1976

Page 2

critical, general issues that could sustain
without
project
getting involved with technical issues of
chemistry or electrophysiology.

a research

These are some

'

Good

luck.
~Sincerely yours,‘

Max

MF:fg

Fink,

M.D.

�</text>
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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—-

EEG

Laboratory

Stony Brook, N. Y. 11794
Phone: 516-444-2447

_

December 22, 1976

Ms. Marion M.

Brault, Staff Assistant

Cooperative Studies Program
Veterans Administration
Department of Medicine and Surgery
Washington, D. C. 20h20
Ref:

lSl—I

Dear Ms.

Brault:

I plan to attend the Veterans Administration
7 and enclose a copy of my
abstracted C.V. I look forward to reading the material
submitted by Dr.Karacen.

meeting of February

Sinc rely yours,

Fink, M.D.
Professor of Psychiatry

Max

Mszg

encls.

�</text>
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Health Sciences Center
I948

School of Medicine

Department of Psychiatry and Behavioral Science

'

Psychopharmacology
Iaatxaratory

-

—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

,

December 23, 1976

Dorothy Dobbs, M.D.
Abbott Laboratories
Abbott Park
North Chicago, Illinois

6006M

Dear Dottie:

In checking

my

files I

protocol, dated October 12,

found the enclosed draft
1973 for an EEG assay of

SP—l (A—hOlTh) and some notes regarding conversations
with Drs. George O'Brien and B. D. Holland. The file
contains summaries of two studies by A. S. Keats.

best as I recall, we negotiated an agreement,
supplies, when I received a call
terminating the discussions.
As

and were awaiting

for

It

was good

to talk to you again.

a healthy and happy 1977.

My

best wishes

Sincerely,

M

Fink, M.D.
Professor of Psychiatry

Max

MF:fg

encls.

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                    <text>STATE UNIVERSITY

05 NEW YORK AT

Health Sciences Center

-

srom

BROOK

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

-—

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

,

Laboratory

'

_

,

December 23, 1976

Keith F. Killam, _Ph.D.
Department of Pharmacology
School of Medicine
University of CalifOrnia - Davis
Davis, California 95616

Dear Keith:

Mindful of your comments at the ACNP meeting
in New Orleans, I am writing to ask for a list of citations
(and copies of the reprints if available) describing your
studies of psychoactive drug effects in simians.
The meeting was a good one, and you

are to be con-

gratulated in successfully weathering the stormy
an

officer of
My

ACNP.

voyage as

thanks and best.wishes for a healthy 1977.

Sincerely,

M

MF:fg

Max Fink, M.D.
Professor of Psychiatry

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

is

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

—

EEG

/

W

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

Dec ember

23, 1976

Mr. Don Cheetham

Smith, Kline and French Laboratories
1500 Spring Garden Street
Philadelphia, Pa. 19101

‘

Dear Don:
At the ACNP meetings, I shared a problem with
John Buckley and he referred-me to you. I am establishing
a clinical psychopharmacology research unit at the VAH -

Northport. Before giving our patients

new,

active

com-

pounds we wish to have them drug free for one to four
weeks, and can only do so if we give them a medication,
albeit inactive. Can you supply us with 1000 each of
50 mg and 100 mg PLACEBO — Thorazine?’
Thorazine remains the most frequently used antipsychotic and we

transfer patients to placebo with minitheir part, or that of the nurses.
have two studies approved, which will begin

should be able to

mal anxiety on
We

in January: clozapine in tardive dyskinesia; and a phase-I
evaluation of a new psychoactive drug, GC—h6.
,

-

let

If there is

me know.
My

a charge for such supplies, please

best regards.

Mszg
cc: John Buckley

-,

Sincerely,
Max Fink, M.D.
Professor of Psychiatry

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                    <text>STATE UNIVERSITY OF NEW YORK AT STONY BROOK

Health Sciences Center

-

School of Medicine

Department of Psychiatry and Behavioral Science
Psychopharmacology

——

EEG

Stony Brook, N. Y. 11794
Phone: 516-444-2447

Laboratory

December 23, 1976

Stanley van den Noort,

M. D.

Dean

California College of Medicine
University of California Irvine
Irvine, California 92717
—

Dear Dr. van den Noort:

I am pleased to submit this reference on behalf
of Dr. Jon Heiser. I have known of his research interests
from his publications, and came to know him much better
during my recent stay at Irvine as a member of the visiting
faculty.

In his writings and our discussions, he has im—
pressed me as innovative, logical, and careful. His studies
of physostigmine and propranolol are significant additions
to medical therapy. These developments were based on care—

ful clinical observations, logical inference,

and extensive

pharmacologic knowledge. In his discussions of his present

interests in computer diagnosis and information processing
for psychiatry, he shows an active interest in an important

and developing research problem.

'

is a reserved,.pleasant, and responsible person,
interested and enthusiastic participant in my

He

who was an

seminars.

I

am

pleased to

recommend him;

to consider
if
ber of this University faculty.
even more pleased

he were

a

although I would be

position as a

his.

mem—

Sincerely,

Mszg

Fink, M.D.
Professor of Psychiatry

Max

,

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.

December 27, 1976

Robert Wallerstein, M.D.
Chairman, Department of Psychiatry
Langley Porter Neuropsychiatric Institute
u01 Parnassus Avenue
San

Francisco, California 9u1u3

Dear Bob,
mm pleased to submit this letter of reference on
Dr. Lorrin Koran whom I have known since the summer of
1972 when he joined the faculty of Stony Brook. During these
four and a half years, I have known him as a fellow teacher,
committee member, and co-worker on a number of proéects.

behalf of

I

For the past two years, I have urged Larry to undertake

research studies in

my Diviiion. His decision to return to
California is a keen disappointment to me, for I have found him
to be one of the brightest and thoughtful young men in the

some

Department.

He is a fine teacher. He accepted responsibility to
the
develop
Psychobiology systemsteaching program. He prganized
the staff well, and attended all the sessions during the first
year. The students were treated to a mentor-student relationship
that is rarely seen, and the students were keenly responsive
to his interest. The same can be said for the daculty-- I do
not think that I have been called upon to work as hard, nor to
satisfy as high standards, as in participating in this course.
During the past year, he repeated the effort, and his leaving the
Department will leave a void that will be difficult to fill.
He

is

He

is personable, reliable,

an innovative thinker. He has developed some
ideas
as to the biochemical basis of schizophrenia-—
interesting
ideas that are quite consonant with the type of work that is
ongoing at the Institute.

faculty, staff,

highly.

and

and well liked by the
miss
I
him, and commend
will
students.

Sincerely yours,
Fink, M.D.
Professor of Psychiatry
Max

him

“mm—"v...“

nwm- .. w “was“ m
7

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                    <text>r...

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December 29, 1976

Ing.

M.

Matejcek

Sandoz Ltd.
#002 Basel, Switzerland
»

Dear Matejcek,

I was pleased to receive the enclosed inquiry and as
I answered the many questions, I became more enthusiastic; hence
this letter. Many years ago, in 1968 and again in 1969, I organized
meetings in my laboratory in New York. I remember a session at
which Creuzfeldt came and argued very logically for more basic
studies. At the time, I ignored his comments, but lately that
need had become all the more apparent.
I know that some workers are occupied with the technical
issues of electrodes, EEG reduction methods, etc. But these issues
have been solved, to some extent, and what seems to be needed, are
studies relating the EEG changes to behavior. The diagnostic use
of EEG profiles to define new drugs has been successful; some
applications to pharmacodynamics have been interesting; but we
lack the understanding of the significance of fast waves for
behavior for example. Past waves increase after barbiturates
(sedatives) and thymoleptics. Are the chemical changes in the
brain the same or do these same rhythms reflect different chemistries?
Or, as is also likely, we have not yet resolved the differences
in the fast waves after barbiturates and thymoleptics ? Further,
of what predictive value for neurohumors are the EEG changes.
We know that anticholinergic drugs elicit the same BEG effects
as the thymoleptics. Does that mean that thymoleptics act via
a reduction of acetylcholine in the brain ? And so on.
have struggled for years to have pharmaco—BEG recognized
At the ACNP, for example, each of the early years
was marked by an BEG symposium, but these became redundant and
the memebers disinterested when we failed to show the scientific merit
of the work. At times, the data has been presented at psychiatric
and at BEG meetings, but these disciplines are interested mainly
in the practical uses, and ever since psychiatrists decided to ignore
the sedation threshold work of Shagass, Goldman and
they have
We

at major meetings.

Itil,

.

-..

v.

_ yum-“1......—pg,» .-

�..........December 29,

Mr. Maeejcik

1976

..... ......

page

2

ignored the new developments in EEG and drugs. I think that
meetings should be held independent of the main societies, and
related th them mainly for the convenience of timing and the
reduction in expense. Surely, meetings should be organized
alternately in the U.S. and Europe, perhaps in Asia when the
opportunity presents. If a meeting can be held in a working
laboratory, then it should be held there-- giving the participants
a chance to see the facilities and ask questions regarding tech—

nical issues.

Society should be organized formally, with rules and

The

by—laws

to privide

he graduated.

some

continuity

and some dues which could

The restoof the answers are on the form. Perhaps the
meeting could be held in Amsterdam at the International
EEG In September 1977 ? With a visit to Paris at the time of
the course in EEG to Btevenon, or to Basle ? ? ?

first

My

best wishes

Ma

healthy and a successful 1977

.,._.,-r

Sincerely yours,

Pink, M.D.
Professor of Psychiatry
Max

I

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January 5, 1976
William E. Fann, M.D.
Baylor College of Medicine
Texas Medical Center
Houston

TEXAS;

Dear

77025

Bill,

Enclosed is a draft copy of the report that I presented
at the depression sessions in Houston early last month. I recall the
sessbons with great pleasure and trust that this report meets the

high standards of your volume.
My

best to Bruce,

successful 1976.

and my

best wishes for a

happy and

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

*—‘vwn'ﬂv-"v‘(r‘1r«

,ow—uwmv‘V-‘—_—V'Oi=A-I‘VV‘W

�</text>
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                    <text>m

—.

n

wwnuwam

ww,j—v‘r'r,4

q’w—‘lvw

.
w
v—

‘W’v‘rw-rv'w“"'

,.,_ un- ~-.

wr _,_ wwl' «_ t...“—7 _,_Wm

ammm W mt. _ mm.
I

,_,,

'r-u'.

x

.

_..m....... u...‘ «qr-v.”

.... v

w"

.w—w

wlw-‘wr.m-1nm&lt;\m‘&lt;~—_ ..m.....—.~.._...w...,..W” .mwv

January 22, 1976
Iver Small, M.D.
Secretary, Society for Biological Psychiatry
Indianapolis, Indiana
Dear

Iver,

First, let me thank you for the invitation to participate
in the workshop on ECT at the WCBR. I thought the session well
attended, the questions excellent, and the presentations served to
alert this audience to the interesting possibilities in ECT research.
Paul met me for dinner that evening and we were able to discuss the
many problems in California and the possible resolutions, which he
may bring up at the task force meeting.
I am writing on another matter as well. For a number of
years, Don Klein has been active in trying to arrange a meeting of
interested learned societies to bring the benefits of biomedical
research to the attention of society. He has alerted me to his
efforts which I strongly endorse. He has asked me to solicit the
support of the Society of Biological Psychiatry.

I enclose his letter to Jolly West, and ask that you
bring up the participation of the Society in this worthy effort
the next Council meeting. I am confident that you will have the
full support of Charlie Shagass and Arnie Friedhoff.
Many

at

thanks.

.nrw.~nm-Wwvm

Sincerely yours,
-

v

nv‘wu

emu

Fink, M.D.
Professor of Psychiatry
Max

M—wm

N...

�</text>
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                    <text>urn—w...“

w wwwn—‘v \‘ny-"vuv'wvnvrw'Iw-w

wu'p.“~“nag-:7... “um...

..

-...

v

_

January 22, 1976
Donald F. Klein, M.D.

Hillside Hospital

Geln Oaks, New York
Dear Don,
am pleased that your idea for a consortium meeting on
research
biomedical
is progressing. I have written to Iver Small,
in his capacity at secretary of the Society of Bioihgical Psychiatry,
and have asked his support at the next meeting of Council. Since that
will be in June, if you have need of the Society support before
that time, please write to him directly, and I am confident that
he will act positively, even before the Council meets formally.

I

the

next you talk to Charlie, remind him that you need
support, as he is an active member of the Council.
When

SBP

Good

luck.
Sincerely yours,
Max

Fink,

M.D.

�</text>
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                  <elementText elementTextId="106996">
                    <text>.7

7...?” “my..."vnuw-‘m.w—WWAmmw—mxu—&lt;—-.e-r:.-..m—«~

~u—eww

H'-

,

-

'

.

'

*

-

-’~'

"

‘

‘

n.

.

w.

-

,H

..

February 6, 1976

,,.

\._

w

‘1-1.

..

v...

mm

mm

”.4,

Fisher
Hospital Practice

Mr. David
hBS
New

Madison Avenue
York City

any

Dear Mr. Fisher,
On

two occasions, endocrinologists of prominence have

referred to articles in Hospital Practice as excellent reviews of
recent work. In answering a question for Dr. Dputhy Krieger,
she also told me of the report in your Journal.
I have checked with our library
available.

and the Journal

is not

May I ask how one can get a subscription or copies beginning
with April 1975 ?
.

Many

thanks.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

�</text>
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                    <text>H.

r-..

.

mu, .M was» m'so-

tw-‘rrVrv-n www.c—

-.x pm,

-0"va w-ur—a «n mwrw-

em“. a-.- -w'

w.

..-.VV._:....

,.

“kw".

. a

Jun—-m—ns.

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,

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PW
February 13, 1976
Mr. Gary Seidler
Editor, The Journal

Addiction Research Foundation
33 Russell Street
Toronto, Canada
Dear Mr.

Seidler,

For a number of years, I have subscribed to the
During
this time, I have watched the scientific quality of
Journal.

the reports deteriorate, with the report by Ms. MacLennan, describing
an interview with Dr. Eugene LeBlanc, the latest low point for opinion
without evidence.
At no point in the report is there any data presented. One
tell if Dr. LeBlanc is a researcher, admonisher, or administrator;
and if he is a researcher, I cannot find a clue as to the type of
work that he does which Justifies his opinions.

cannot

It is sad that the newspaper of a research organization
serves to print opinions without basis in fact. The issues regarding
cannabis are controversial, and we seem to need more light and less
heat. I wonder if your office will try to report the transactions
of the recent chronic cannabis use conference in New York; or the
results of the Greek study of Stefania and Dornbush (a copy was
sent to the Foundation last summer ); or the 197% meeting sponsored

by NIDA on cannabis

?

I fear I shall not find out, for I
to
subscription
lapse. I am disappointed.

have allowed

my

Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Max

rwww

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                    <text>February 17, 1976

Doris H. Milena. M.D.

Professor

Department of Pediatrics
Dovnetate Medical Center

BURY

Deer Dr. 1411mm:

All subjects with e chronic history of cannabis use were included
in the sample. Both subjects and controls received the some inquiry and
none of the users rare excluded for neurological dysfunction. Exclusions
were: over age 58 (h); concurrent heroin uee (3). alcohol use (3); and
amphetamine use (1).
.

a

:
-

w

"Saw—sz'rl‘warvmnwum‘m‘

v

In our neurological reviews, we bed h subjects in the user group
in the control group with abnormal EEG. or both groups, heed injury
within 3 years was present in 2 users and 1 control, and in the users, these
two were the only subdecte with an asymmetric EEG record.
and 6

The study was undertaken on the invitation of Professor Mirna
who referred 28 cases to us. He cooperated in the study supplying the heehish

used in the acute studies.
and

EEG

We

failed to confirm his preliminary observations,

he is satisfied that the original reports were based on poor
recordings and clinical global aeoesemente of organioity without controls.

I believe

The principal differences between users and controls are found in
tolerance to heehieh, some medical findings of a non—specific nature, and
in social factors (After all, users persisted in criminal behavior - buying,
selling, and smoking e prohibited substance ~ despite frequent Jeiling).

point of view, the most important findings were the
brain disease. aggressivity, or social with—
drawal and the positive evidence of tolerance. It turns out that cannabis
substances obey the basic love of pharmacology (re found no "reverse toler~
nude" for example); that it is a remarkably safe relaxant and euphorient.
and in contrast to alcohol. does not elicit aggressivity. Indeed if one had
to select e CNS active drug to use, cannabis is remarkably safer than alco—
hol, opiates and probably equivalent (can one ever any it?) to tobacco.
From my own

negative ones
—

-

no evidence of

The full study will he published this Fall by Raven Press as
Long Term Heehish Use, edited by Stefania, Dornbush and Pink. You may also
wish to read the Reunion study (Qggﬁe in Jgggice, ed. by Rubin and Comitee)
end the forthcoming report "Chronic Cannabis Use", H.Y. Academy of Sciences,

edited

by Deonhueh.

Thank you

fer your thoughtful inquiry.
Sincerely yours,
Fink, M.D.
Professor of Psychiatry

Mex

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                    <text>f

[fl/jaw

December 23, 1976
Mr. Harry Henderson

Editor

World Wide Medical
880 Third Avenue
New York 10022

Press, Inc.

Dear Mr. Henderson,

is accurate, and I congratulate
you provide. I have a few comments that

For once, the reporting

you on the summary
may be helpful.

that

1. The effect of the Massachusetts reporting system has
been salutary, and the follow up report by Grosser in the
Massachusetts Journal of Mental Health, Spring 1975 could be

referred to.

The report finds that the institutions reporting their
seem to be following the guidelines set by the medical
communitym and such self monitoring is much to be preferred to the
EST

experience

California

model of

legal restraint

and

interference.

2. Leonard Cammer is a curmudgeon, representing the
opinion of himself and a few die-herds. He and-his associates
fail to see that with the development of third party payers, and
government funding, there will be regulation of medical practice.
Whether the regulation is made by the State and external to the
medical community, or by them-edical community is the issue. The
members of this APA Task Force seem inclined to develop models of
education and self regulation and it is probable that their thoughtful
recommendations will be accepted by the 20,000 members of the APA.
I believe you give undue weight to a very minority opinion by quoting
his (Leonard's) very conservative and 19th Century approach at length.
«m

".41:

-

WI7‘F'IYv

A
.

3. Dr Tien is a poorly trained, misguided therapist who
has produced many articles of uncontrolled,'studies'. His approach
is far from the mainstream of world psychiatry and again, you do the
serious students of psychiatry a disservice by quoting his remarks.
Better you should have quoted Dr. Friedberg, a young resident from
Oregon who did present the negative views of EST rather forcefully
in the same session at which Greenblatt and I spoke. The American
Psychiatric Association has decided, that despite the ad hominem
and erroneous nature of Freidberg's remarks, the American Journal
of Psychiatry will publish his remarks as well as those of the other
panellists at the session you quote. I would urge you to relegate

�H.

Henderson..........

December 23, 1976

.......... page

2

to his private world. Incidentally, your references to the
society in the same article as the established society suggests
that somehou, the new group represents the professionals who have
an active interest in EST. That is not so, since few of the
authorities that you may wish to quote and who have carried the
Dr. Tien

new

burden of research these many decades have joined

Cammer

and Tien.

4. Since that presentation, Avery and Winokur, in a
very forceful article in the AMA Archives of General Psychiatry
(33:1029-1037,1976) indicate the importance of EST in reducing the

incidence of death in depressive illnesses. Their findings are
striking for deaths by suicide, but equally for deaths from all
causes. I commend their article to you. Another important study is
that of McCabe (Amer J. Psychiat. 133:688-691, 1976) who finds EST
as effective, and often more so, than other treatments of mania.
The importance of his review is the data that the time for
response
is notably shorter for EST than for drug therapies—— a finding
that
should serve to reduce the mortality among manic patients who frequently succumb during the first week of treatment.
I trust these comments are helpful. While I have good
press photos, I regret that I am of sound mind and do not wish to
have my face presented in the lay press. My opinions matter
little;
the results of my research do, and when someone wishes to describe
my laboratory's work, I would be pleased to supplement the reports
with pictures.
My

regards and best wishes for a successful 1977.
Sincerely yours,

:-:

v...

-u,«.w.'

«n;

«t,»

q'w'

“wry-v

-..

war

:91

1m

ﬂi'jrﬁr

-

..
gun-w.

..

www.myv...

W

Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>March 1, 1976

Earl Usdin, ?h.D.
Chief, Pharmacology Section

Psychoyhnrmocology Reseeroh Branch
Department of Health, Education, and Welfare

Fublic Health Service
National Institute of Mental Health
5600

Fishers

Deer

Earl:

Rockville,

Leno
20852

Md.

Enclosed is a corrected copy of my discussion for the Aailomer
Conference. I would be grateful if you would make the corrections
on page: 1 and h, as indicated in this copy.

I

hope

the proceedings are

coming along

well.

Sincerely yours.
Pink, M.D.
Profeeoor or Psychietzy
Me:

�</text>
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                    <text>March 8, 1976

Giuliano Dolce,

M.D.

E. Merck

Darmstadt, Germany
Dear Giuliano,

writing to thank you for your fine care during my
recent visit. I enjoyed the dinner very much, and I am only sorry
that my worries about my luggage may have depressed the party. Inge
took excellent care of me, and I thank you both.
I

am

the airport, my luggage arrived 1 hour before my plane for
Paris, so all was well. ( When I flew from Paris to New York, my
bag was missing at Kennedy and it arrived on a later plane that night 7
It was a wayward bag.)
At

reflection, I agree with the decisions made
at our meeting. Should the new clinical data suggest that a study
with detailed electrophysiology and psychology would be helpful, it
can be organized at a later date.
After

some

I met with Karl Rickels, and discussed the protocol he
submitted. I think he will go ahead with his study and we came to
an easy understanding regarding the IND and the details of the study.
Should Merck decide to invite me to act as their consultant, he ddd
not feel, as I do not, that there is any conflict.
Walter has passed his U.S. ECFMG tests. He is busy writing
two reports, and has received his NIMH awards- so I hope that he will
be able to come back this fall to complete his studies. He returns

to

Europe

at the

Again,

end of April.
my

thanks to Inge and

my

best regards.

Sinceeely yours,
Fink, M.D.
Professor of Psychiatry
Max

�</text>
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                    <text>March 10, 1976

Dr. Lannnrt Klaus

KunsshﬁsIVngn 9
I~260 lh GlumslSv
Sweden

Dear Dr. Klaus,
and

Your

letter of

Just forwarded

to

me

23 Dooembur VI! sent

to

my

former University,

- I regret tho delay in replying.

Following our work on oyelazocine and naloxone, as referred
the U.8. Government actively supported the developmznt of
1971,
in
to
new
antagonist, noltrexnno. This ﬁrm; ho: had uxtonsivo clinical
a
antagonists. Clinical trials
triols, and now seen: superior to earlier
and
the
drug is not yet marketed.
under
auxpioos,
research
are still

laboratories which tested the antagonists found their
difficult. When patients have the choice between methadone or
naltrcxonc. thqy surely prefer mathadone. I bolieve that in N.Y., only
my {armor co~worker. Dr. Riohard Rounick in actively using naltrexone.
He reports good clinical results.
I do not believe thot nnltrexone will be very successful,
especially when it oontinuon to compote with nothadono.
use too

Most

Thank you

for your inquiry.
Binoerely yours,
Max

Fink,

M.D.

Profelsor of Psychiatry

�</text>
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                    <text>March 11, 1976

Susanna St. Pierre

v. 571:1: Street
"Sixty Minutes"
52h

How

York. N.Y.

Dear Mt.

10019

St. Pierro,

I spot. to 9r. Frankel and he luggostod the enclosed in—
foamotion may be of interest. This draft of a report given last
woek will be edited, but the sense of it may provide some
balance in a review.
I also enclosed abstracts from two publications about EST
may assist you in your review. One answers questions presented
clinicians; the other summarizes the clinical material at the 1972

vhich
by

conference.

you well know, the issues about EST are emotional and
politicized. The science tends to get stomped. Mike Wallace, like
Earl Ubell some years ago, has a reputation for scholarship. I
As

you will consider carefully how you prosent the data, and not
inflows on already unhappy state, as did Frank Field a few weeks ago.

trust

Sincerely yours,
Fink, M.D.
Professor of Paychiatry

Max

�</text>
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